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https://www.readbyqxmd.com/read/28202210/investigating-adverse-events-following-immunisation-with-pneumococcal-polysaccharide-vaccine-using-electronic-general-practice-data
#1
L Trinh, K Macartney, P McIntyre, C Chiu, A Dey, R Menzies
BACKGROUND: In early 2011, following an increased number of reports of severe vaccine-related injection site reactions, Australian authorities recommended against administering repeat doses of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in otherwise healthy adults. The aim of this study was to assess a source of electronic medical record data from primary care providers (General Practitioners, GPs), for validity and ability to retrospectively detect this adverse event signal...
February 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28162130/influenza-hospitalizations-in-australian-children
#2
J Li-Kim-Moy, J K Yin, C C Blyth, A Kesson, R Booy, A C Cheng, K Macartney
Australia's National Immunisation Program (NIP) provides free influenza vaccination for children at high risk of severe influenza; a pilot-funded programme for vaccine in all children aged 6 months to <5 years in one of eight states, has seen poor vaccine impact, related to recent vaccine safety concerns. This retrospective review examined influenza hospitalizations in children aged <16 years from three seasons (2011-2013) at two paediatric hospitals on opposite sides of the country. Comparisons of this cohort were made with state-based data on influenza-coded hospitalizations and national immunization register data on population-level immunization coverage...
February 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28095818/when-parents-won-t-vaccinate-their-children-a-qualitative-investigation-of-australian-primary-care-providers-experiences
#3
Nina J Berry, Alexandra Henry, Margie Danchin, Lyndal J Trevena, Harold W Willaby, Julie Leask
BACKGROUND: Increasingly, the experiences and perceptions of parents who decline vaccination are the subject of investigation. However, the experiences of clinicians who encounter these parents in the course of their work has received little academic attention to date. This study aimed to understand the challenges faced and strategies used when general practitioners and immunising nurses encounter parents who choose not to vaccinate their children. METHODS: Primary care providers were recruited from regions identified through the Australian Childhood Immunisation Register (ACIR) as having higher than national average rates of registered objection to childhood vaccination...
January 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28086764/an-audit-of-the-quality-of-online-immunisation-information-available-to-australian-parents
#4
K E Wiley, M Steffens, N Berry, J Leask
BACKGROUND: The Internet is increasingly a source of health information for parents, who use the Internet alongside health care providers for immunisation information. Concerns have been raised about the reliability of online immunisation information, however to date there has been no audit of the quality or quantity of what is available to Australian parents. The objective of this study was to address this gap by simulating a general online search for immunisation information, and assessing the quality and quantity of the web sites returned by the search...
January 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28074595/providing-opportunistic-immunisations-for-at-risk-inpatients-in-a-tertiary-paediatric-hospital
#5
Sonja Elia, Kirsten Perrett, Fiona Newall
Attaining high immunisation coverage rates for children with medical conditions is vital. The Royal Children's Hospital (RCH) Immunisation Service has the opportunity to check each inpatient's immunisation status and provide opportunistic vaccines and/or bring the Australian Childhood Immunisation Register (ACIR) up-to-date. This paper highlights that during admission, one quarter of children were not up-to-date with routine scheduled immunisations and 42% of those inpatients due or overdue for immunisation were vaccinated...
January 11, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/28043231/australian-childhood-immunisation-coverage-1-april-2015-to-31-march-2016-cohort-assessed-as-at-30-june-2016
#6
Alexandra J Hendry
No abstract text is available yet for this article.
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28043227/influenza-epidemiology-in-patients-admitted-to-sentinel-australian-hospitals-in-2015-the-influenza-complications-alert-network
#7
Allen C Cheng, Mark Holmes, Dominic E Dwyer, Louis B Irving, Tony M Korman, Sanjaya Senenayake, Kristine K Macartney, Christopher C Blyth, Simon Brown, Grant Waterer, Robert Hewer, N Deborah Friedman, Peter A Wark, Graham Simpson, John Upham, Simon D Bowler, Albert Lessing, Tom Kotsimbos, Paul M Kelly
The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance program that operates at sites in all states and territories in Australia. This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2015 influenza season. In this observational study, cases were defined as patients admitted to one of the sentinel hospitals with an acute respiratory illness with influenza confirmed by nucleic acid detection. During the period 1 April to 30 October 2015 (the 2015 influenza season), 2,070 patients were admitted with confirmed influenza to one of 17 FluCAN sentinel hospitals...
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28043223/australian-vaccine-preventable-disease-epidemiological-review-series-influenza-2006-to-2015
#8
Jean Li-Kim-Moy, Jiehui Kevin Yin, Cyra Patel, Frank H Beard, Clayton Chiu, Kristine K Macartney, Peter B McIntyre
INTRODUCTION: Influenza is a major contributor to the preventable health burden of Australians each year. The National Immunisation Program provides influenza vaccine for those at highest risk of severe disease. This review of influenza epidemiology examines current data on influenza disease burden in Australia, in the context of several comparable countries having programs with much broader eligibility for influenza vaccine in children. METHODS: Influenza notifications (2006-2015), hospitalisations, and deaths (2006-2013) were sourced and age-specific rates calculated...
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/27986682/long-term-impact-of-a-3-0-schedule-for-7-and-13-valent-pneumococcal-conjugate-vaccines-on-invasive-pneumococcal-disease-in-australia-2002-2014
#9
Sanjay Jayasinghe, Rob Menzies, Clayton Chiu, Cindy Toms, Christopher C Blyth, Vicki Krause, Peter McIntyre
BACKGROUND: Australia introduced universal 7-valent pneumococcal conjugate vaccine (PCV7) from 2005, replaced by 13-valent PCV (PCV13) in 2011, uniquely among high-income countries giving doses at 2, 4, and 6 months (3 + 0 schedule). Data on impact of a timely 3 + 0 PCV schedule with high coverage are sparse, with none for PCV13. METHODS: We used national surveillance of invasive pneumococcal disease (IPD) from 2002 for baseline and appropriate later comparison periods to calculate incidence rate ratios (IRRs) by serotype and age using a Poisson model...
January 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27960227/what-do-health-consumers-want-to-know-about-childhood-vaccination-an-evaluation-of-data-from-an-australian-medicines-call-centre
#10
Marnix Mus, Sanne Kreijkamp-Kaspers, Treasure McGuire, Laura Deckx, Mieke van Driel
OBJECTIVES: Immunisation is crucial to population health. This study aimed to identify the information needs and concerns of health consumers regarding childhood vaccination. METHODS: We analysed 1,342 calls concerning childhood vaccination to an Australian pharmacist-operated medicines call centre (MCC). Data were available from September 2002 until June 2010. We identified key themes and compared these for callers from high and low immunisation coverage areas...
December 13, 2016: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/27916411/beyond-expectations-post-implementation-data-shows-rotavirus-vaccination-is-likely-cost-saving-in-australia
#11
J F Reyes, J G Wood, P Beutels, K Macartney, P McIntyre, R Menzies, N Mealing, A T Newall
BACKGROUND: Universal vaccination against rotavirus was included in the funded Australian National Immunisation Program in July 2007. Predictive cost-effectiveness models assessed the program before introduction. METHODS: We conducted a retrospective economic evaluation of the Australian rotavirus program using national level post-implementation data on vaccine uptake, before-after measures of program impact and published estimates of excess intussusception cases...
January 5, 2017: Vaccine
https://www.readbyqxmd.com/read/27876203/impact-of-the-national-targeted-hepatitis-a-immunisation-program-in-australia-2000-2014
#12
Craig Thompson, Aditi Dey, Emily Fearnley, Benjamin Polkinghorne, Frank Beard
In November 2005, hepatitis A vaccine was funded under the Australian National Immunisation Program for Aboriginal and Torres Strait Islander (Indigenous) children aged 12-24months in the targeted jurisdictions of Queensland, South Australia, Western Australia and the Northern Territory. We reviewed the epidemiology of hepatitis A from 2000 to 2014 using data from the Australian National Notifiable Diseases Surveillance System, the National Hospital Morbidity Database, and Australian Bureau of Statistics causes-of-death data...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/27862541/paediatrician-beliefs-and-practices-around-influenza-vaccination
#13
James P Newcombe, Rajneesh Kaur, Nicholas Wood, Holly Seale, Pamela Palasanthiran, Thomas L Snelling
AIM: The uptake of influenza vaccination in children with high-risk medical conditions continues to be low in Australia and internationally. We aimed to determine Australian paediatricians' beliefs and practices around the influenza vaccination of children. METHODS: This was conducted as a cross sectional survey of paediatricians from two tertiary paediatric hospitals in Sydney. RESULTS: There were 101 participants. Influenza vaccination was not prioritised compared with other vaccines and clinical issues, with fewer than half of respondents strongly agreeing that influenza vaccination was useful...
November 15, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27842585/immunisation-timeliness-in-a-cohort-of-urban-aboriginal-and-torres-strait-islander-children
#14
Yolanda G Lovie-Toon, Kerry K Hall, Anne B Chang, Jennie Anderson, Kerry-Ann F O'Grady
BACKGROUND: To evaluate immunisation coverage, timeliness and predictors of delayed receipt in urban Australian Indigenous children during the first 18 months of life. METHODS: Cross-sectional retrospective analysis of data collected from 140 Australian Indigenous children aged < 5 years at the time of enrolment in a prospective cohort study on respiratory illness between 14 February 2013 and 28 January 2015. Children were recruited through an urban community primary health care centre in the Northern suburbs of Brisbane, Queensland...
November 14, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27780630/effect-of-tdap-when-administered-before-with-or-after-the-13-valent-pneumococcal-conjugate-vaccine-coadministered-with-the-quadrivalent-meningococcal-conjugate-vaccine-in-adults-a-randomised-controlled-trial
#15
M Tashani, M Alfelali, O Barasheed, A S Alqahtani, L Heron, M Wong, H Rashid, R Booy
Sequential or co-administration of vaccines has potential to alter the immune response to any of the antigens. Existing literature suggests that prior immunisation of tetanus/diphtheria-containing vaccines can either enhance or suppress immune response to conjugate pneumococcal or meningococcal vaccines. We examined this interaction among adult Australian travellers before attending the Hajj pilgrimage 2014. We also investigated tolerability of these vaccines separately and concomitantly. We randomly assigned each participant to one of three vaccination schedules...
October 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27763809/do-australian-immunoglobulin-products-meet-international-measles-antibody-titer-standards
#16
Megan K Young, Joseph Bertolini, Pushpa Kotharu, Darryl Maher, Allan W Cripps
The effectiveness of passive immunisation post-exposure to measles appears subject to a dose-response effect. New Zealand and the United Kingdom have increased the recommended dose of polyclonal human immunoglobulin for post-exposure prophylaxis within the last decade in response to concerns about decreasing levels of measles antibodies in these products. This study used the plaque-reduction neutralization test (PRNT) to measure the titer of measles-specific antibodies in Australian immunoglobulin products for post-exposure prophylaxis and compared the utility of an enzyme-linked immunosorbent assay (ELISA) to the PRNT in available Australian and international samples: Australian intramuscular (n = 10), Australian intravenous (n = 28), New Zealand intramuscular (n = 2), Hizentra (subcutaneous)(USA) (n = 3), and Privigen (intravenous)(USA) (n = 2)...
October 20, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27734063/public-health-amendment-vaccination-of-children-attending-child-care-facilities-act-2013-its-impact-in-the-northern-rivers-nsw
#17
Alice C Fraser, Sarah E Williams, Sarah X Kong, Lucy E Wells, Louise S Goodall, Sabrina Pit, Vibeke Hansen, Marianne Trent
OBJECTIVE: The objective of the study was to explore the impact of implementation of the Public Health Amendment (Vaccination of Children Attending Child Care Facilities) Act 2013 on child-care centres in the Northern Rivers region of New South Wales (NSW), from the perspective of child-care centre directors. Importance of study: Immunisation is an effective public health intervention, but more than 75 000 Australian children are not fully vaccinated. A recent amendment to the NSW Public Health Act 2010 asks child-care facilities to collect evidence of complete vaccination or approved exemption before allowing enrolment...
April 15, 2016: Public Health Research & Practice
https://www.readbyqxmd.com/read/27670446/influenza-and-pneumococcal-vaccination-in-australian-adults-a-systematic-review-of-coverage-and-factors-associated-with-uptake
#18
Amalie Dyda, Surendra Karki, Andrew Hayen, C Raina MacIntyre, Robert Menzies, Emily Banks, John M Kaldor, Bette Liu
BACKGROUND: In the absence of an adult vaccination register, coverage estimates for influenza and pneumococcal vaccination come from surveys and other data sources. METHODS: Systematic review and meta-analysis of studies examining vaccination coverage in Australian adults from 1990 to 2015, focusing on groups funded under the National Immunisation Program, and intervals prior to and following the introduction of universal funding. RESULTS: Twenty-two studies met the inclusion criteria; 18 used self-report to determine vaccination status...
September 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27650763/evaluation-of-the-first-pharmacist-administered-vaccinations-in-western-australia-a-mixed-methods-study
#19
H Laetitia Hattingh, T Fei Sim, R Parsons, P Czarniak, A Vickery, S Ayadurai
OBJECTIVES: This study evaluated the uptake of Western Australian (WA) pharmacist vaccination services, the profiles of consumers being vaccinated and the facilitators and challenges experienced by pharmacy staff in the preparation, implementation and delivery of services. DESIGN: Mixed-methods methodology with both quantitative and qualitative data through surveys, pharmacy computer records and immuniser pharmacist interviews. SETTING: Community pharmacies in WA that provided pharmacist vaccination services between March and October 2015...
2016: BMJ Open
https://www.readbyqxmd.com/read/27580249/an-escalating-dose-study-to-assess-the-safety-tolerability-and-immunogenicity-of-a-herpes-simplex-virus-dna-vaccine-cor-1
#20
Julie L Dutton, Wai-Ping Woo, Janin Chandra, Yan Xu, Bo Li, Neil Finlayson, Paul Griffin, Ian H Frazer
This paper describes a single site, open-label Phase I clinical trial evaluating the safety, tolerability and immunogenicity in healthy volunteers of a herpes simplex polynucleotide vaccine that has previously been shown to enhance immunogenicity and protect against lethal herpes simplex virus type 2 (HSV-2) challenge in mice. Five escalating doses of the vaccine, COR-1, were given by intradermal injection to HSV-1 and 2 seronegative healthy individuals. COR-1 was found to be safe and well-tolerated; the only vaccine-related adverse events were mild...
December 2016: Human Vaccines & Immunotherapeutics
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