keyword
https://read.qxmd.com/read/38545521/prevalence-of-psychiatric-disorders-in-chhattisgarh-findings-from-national-mental-health-survey
#1
JOURNAL ARTICLE
Lokesh Kumar Singh, Anjan Kumar Giri, Vivek Chhalotre, Ravi Kumar Sharma, Girish N Rao, Gururaj Gopalkrishna, Mathew Varghese, Prabhat Chand, Veena A Satyanarayana, D Muralidhar, Aditya Somani
BACKGROUND: Psychiatric disorders are among the leading contributors to disability in India and worldwide. The pattern, prevalence, and distribution of psychiatric disorders in the country and its regions need to be assessed to facilitate early diagnosis and treatment. No study on the epidemiology of psychiatric disorders has been conducted in the Chhattisgarh state. This paper, as part of the National Mental Health Survey (NMHS), discusses the prevalence and pattern of psychiatric disorders in Chhattisgarh state...
November 2023: Indian Journal of Psychological Medicine
https://read.qxmd.com/read/38541205/exposure-to-environmental-pesticides-and-the-risk-of-autism-spectrum-disorders-a-population-based-case-control-study
#2
JOURNAL ARTICLE
Pablo Román, Cristofer Ruiz-González, Lola Rueda-Ruzafa, Diana Cardona, Mar Requena, Raquel Alarcón
Background and Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by challenges in communication, social interactions, and repetitive behaviors. Although the factors that influence the development of this condition are unknown, certain chemical compounds such as pesticides have been proposed as possible contributors. Due to the lack of an established causal link between pesticide exposure and ASD, this study aimed to evaluate this potential association. Materials and Methods : A case-control study was carried out to ascertain the prevalence and risk associated with ASD in relation to pesticide exposure over a 21-year study period (2000-2021)...
March 14, 2024: Medicina
https://read.qxmd.com/read/38539347/chronic-pain-in-autistic-youth-clinical-prevalence-and-reflections-on-tailoring-evidence-based-interventions-from-an-interdisciplinary-treatment-team
#3
JOURNAL ARTICLE
Gloria T Han, Holly S Heavner, Thomas R Rains, Alan H Hoang, Amanda L Stone
Though there is growing awareness of the overrepresentation of autistic patients in chronic pain clinics, potential adaptations for the assessment and treatment of chronic pain in this population have not yet been established. To address this gap, a retrospective review of electronic medical records and discussions by an interdisciplinary pain treatment team were summarized to inform potential biopsychosocial factors affecting the presentation, assessment, and treatment of chronic pain in autistic youth. Our sample included a record review of 95 patients receiving treatment in an interdisciplinary outpatient pediatric pain clinic...
March 6, 2024: Children
https://read.qxmd.com/read/38538232/properties-of-the-caudal-pontine-reticular-nucleus-neurons-determine-the-acoustic-startle-response-in-cntnap2-ko-rats
#4
JOURNAL ARTICLE
Alice Zheng, Rajkamalpreet S Mann, Dami Solaja, Brian L Allman, Susanne Schmid
BACKGROUND: Rats with a loss-of-function mutation in the contactin-associated protein-like 2 ( Cntnap2 ) gene have been validated as an animal model of autism spectrum disorder (ASD). Similar to many autistic individuals, Cntnap2 knock-out rats ( Cntnap2-⁣/- ) are hyperreactive to sound as measured through the acoustic startle response. The brainstem region that mediates the acoustic startle response is the caudal pontine reticular nucleus (PnC), specifically giant neurons in the PnC...
March 20, 2024: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38534800/disruption-of-circadian-sleep-wake-rhythms-in-infants-may-herald-future-development-of-autism-spectrum-disorder
#5
JOURNAL ARTICLE
Teruhisa Miike, Kentaro Oniki, Makiko Toyoura, Shiro Tonooka, Seiki Tajima, Jun Kinoshita, Junji Saruwatari, Yukuo Konishi
We investigated whether the abnormal rhythms in infants are related to the future development of autism spectrum disorder (ASD), using a questionnaire from September to October 2016. The parents of 160 children with ASD (male, n = 123; female, n = 37) were recruited from two hospitals in K and H cities, and as a control group, 145 children (male, n = 75; female, n = 70) were recruited from four nursery schools in T city. The associations between ASD and bedtime and waking time on weekdays and weekends in infancy (<1 years of age), at 1-3 years, and at 3-5 years of ages were studied using a multivariable logistic regression analysis...
March 15, 2024: Clocks & Sleep
https://read.qxmd.com/read/38531017/clinical-characteristics-developmental-trajectory-and-caregiver-burden-of-patients-with-creatine-transporter-deficiency-slc6a8
#6
JOURNAL ARTICLE
Aurore Curie, Laurence Lion-François, Vassili Valayannopoulos, Nathalie Perreton, Marie Gavanon, Nathalie Touil, Amandine Brun-Laurisse, Fahra Gheurbi, Marion Buchy, Hulya Halep, David Cheillan, Catherine Mercier, Anaïs Brassier, Béatrice Desnous, Behrouz Kassai, Pascale De Lonlay, Vincent Des Portes
BACKGROUND AND OBJECTIVES: Creatine transporter deficiency (CTD) is a rare X-linked genetic disorder characterized by intellectual disability (ID). We evaluated the clinical characteristics and trajectory of patients with CTD and the impact of the disease on caregivers to identify relevant endpoints for future therapeutic trials. METHODS: As part of a French National Research Program, patients with CTD were included based on (1) a pathogenic SLC6A8 variant and (2) ID and/or autism spectrum disorder...
April 23, 2024: Neurology
https://read.qxmd.com/read/38529081/autistic-traits-and-aggressive-behavior-in-chinese-college-students-a-serial-mediation-model-and-the-gender-difference
#7
JOURNAL ARTICLE
Chenghui Tan, Huan Song, Shanshan Ma, Xinyu Liu, Yuan Zhao
BACKGROUND: The existence of aggressive behavior in autism spectrum disorders (ASD) raises questions about whether cognitive and emotional factors in social information processing play a role between autistic traits (ATs) and aggressive behavior in the general population, especially in the context of Chinese culture. Moreover, given a possible gender difference in these variables, the study aimed to examine the effect of ATs on aggressive behavior, and the potential mediating role of hostile attribution bias and alexithymia on this association, as well as gender difference...
2024: Psychology Research and Behavior Management
https://read.qxmd.com/read/38528973/national-survey-on-bladder-and-bowel-dysfunctions-in-autism-spectrum-disorder-population
#8
JOURNAL ARTICLE
Marilena Gubbiotti, Matteo Balzarro, Leonardo Zoccante, Gianfranco Di Gennaro, Moreno Marchiafava, Chiara Bedetti, Emanuele Rubilotta
INTRODUCTION: To evaluate lower urinary tract symptoms (LUTS) and bowel disorders in a population of young subjects with autism spectrum disorder (ADS) by a national survey and to assess the relationship between the occurrence, frequency, and type of LUTS and the severity of behavioral and neuropsychiatric characteristics. MATERIALS AND METHODS: A survey on LUTS and bowel disorders in the ASD population was sent by mail and social media through the main Italian Associations of ASD between February and September 2022...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38513995/towards-understanding-sex-differences-in-autism-spectrum-disorders
#9
REVIEW
Karen Q Leow, Mary A Tonta, Jing Lu, Harold A Coleman, Helena C Parkington
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability and potential comorbidities often lead to diagnostic and therapeutic challenges. This review addresses the biological basis of ASD, focusing on the sex differences in gene expression and hormonal influences. ASD is more commonly diagnosed in males at a ratio of 4:1, indicating a potential oversight in female-specific ASD research and a risk of underdiagnosis in females...
March 19, 2024: Brain Research
https://read.qxmd.com/read/38508482/the-role-of-glia-in-the-dysregulation-of-neuronal-spinogenesis-in-ube3a-dependent-asd
#10
JOURNAL ARTICLE
Zachary Gardner, Otto Holbrook, Yuan Tian, KathrynAnn Odamah, Heng-Ye Man
Overexpression of the Ube3a gene and the resulting increase in Ube3a protein are linked to autism spectrum disorder (ASD). However, the cellular and molecular processes underlying Ube3a-dependent ASD remain unclear. Using both male and female mice, we find that neurons in the somatosensory cortex of the Ube3a 2× Tg ASD mouse model display reduced dendritic spine density and increased immature filopodia density. Importantly, the increased gene dosage of Ube3a in astrocytes alone is sufficient to confer alterations in neurons as immature dendritic protrusions, as observed in primary hippocampal neuron cultures...
March 18, 2024: Experimental Neurology
https://read.qxmd.com/read/38503925/increased-gene-dosage-of-rfwd2-causes-autistic-like-behaviors-and-aberrant-synaptic-formation-and-function-in-mice
#11
JOURNAL ARTICLE
Yong-Xia Li, Zhi-Nei Tan, Xu-Hui Li, Boyu Ma, Frank Adu Nti, Xiao-Qiang Lv, Zhen-Jun Tian, Riqiang Yan, Heng-Ye Man, Xin-Ming Ma
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions, communication deficits and repetitive behaviors. A study of autistic human subjects has identified RFWD2 as a susceptibility gene for autism, and autistic patients have 3 copies of the RFWD2 gene. The role of RFWD2 as an E3 ligase in neuronal functions, and its contribution to the pathophysiology of ASD, remain unknown. We generated RFWD2 knockin mice to model the human autistic condition of high gene dosage of RFWD2...
March 19, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38500080/experts-perspectives-on-the-impact-of-visual-impairment-and-comorbid-mental-disorders-on-functioning-in-essential-life-domains
#12
JOURNAL ARTICLE
Marjolein LA Onnink, Lisanne Ba Teunissen, Peter Fj Verstraten, Ruth Ma van Nispen, Hilde Pa van der Aa
BACKGROUND: Visual impairment (VI) with comorbid mental disorders (MDs) are expected to have a major impact on people's daily functioning, for which tailored support is needed. However, this has been barely investigated. Therefore, this study aimed to (1) determine the impact of VI and comorbid MDs on functioning in essential life domains, (2) gain insight into best-practices that are currently used to support this target group, and (3) determine strategies to optimize care in the future...
March 18, 2024: BMC Psychiatry
https://read.qxmd.com/read/38497251/where-do-autistic-people-work-the-distribution-and-predictors-of-occupational-sectors-of-autistic-and-general-population-employees
#13
JOURNAL ARTICLE
Yael Goldfarb, Franziska Assion, Sander Begeer
Studies on employment of autistic individuals mainly assessed if they work and what their working conditions are (e.g. weekly hours, salary) while less is known about where they work. We explore this issue in our study, by examining which employment sectors do autistic adults work in, and comparing them to the general workforce in the Netherlands. We also explored the possibility that gender, age, age at diagnosis, level of education, degree of autistic traits and presence of focused interests could lead to a higher likelihood of working in specific sectors...
March 18, 2024: Autism: the International Journal of Research and Practice
https://read.qxmd.com/read/38496641/developmental-differences-in-reaching-and-placing-movement-and-its-potential-in-classifying-children-with-and-without-autism-spectrum-disorder-deep-learning-approach
#14
Wan-Chun Su, John Mutersbaugh, Wei-Lun Huang, Anjana Bhat, Amir Gandjbakhche
Autism Spectrum Disorder (ASD) is among the most prevalent neurodevelopmental disorders, yet the current diagnostic procedures rely on behavioral analyses and interviews and lack objective screening methods. This study seeks to address this gap by integrating upper limb kinematics and deep learning methods to identify potential biomarkers that could be validated in younger age groups in the future to enhance the identification of ASD. Forty-one school-age children, with and without an ASD diagnosis (Mean age ± SE = 10...
March 4, 2024: Research Square
https://read.qxmd.com/read/38493236/predictors-of-health-related-quality-of-life-for-children-with-neurodevelopmental-conditions
#15
JOURNAL ARTICLE
Maryam Mahjoob, Robyn Cardy, Melanie Penner, Evdokia Anagnostou, Brendan F Andrade, Jennifer Crosbie, Elizabeth Kelley, Muhammad Ayub, Muhammad Ayub, Jessica Brian, Alana Iaboni, Russell Schachar, Stelios Georgiades, Rob Nicolson, Jessica Jones, Azadeh Kushki
Neurodevelopmental conditions can be associated with decreased health-related quality of life; however, the predictors of these outcomes remain largely unknown. We characterized the predictors of health-related quality of life (HRQoL) in a sample of neurodiverse children and youth. We used a cross-sectional subsample from the Province of Ontario Neurodevelopmental Disorders Network (POND) consisting of those children and young people in the POND dataset with complete study data (total n = 615; 31% female; age: 11...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38492741/-neurodevelopment-and-neuroprotection-in-young-children
#16
JOURNAL ARTICLE
Stéphane Marret, Alexandra Chadie, Jean-Baptiste Muller, Clément Chollat
In France, the most pessimistic estimates put the prevalence of neurodevelopmental disorders (NDD) at 15% of births. The two largest populations of newborns at highest risk of NDD are premature babies and babies born into siblings with one or more infants who already have an autism spectrum disorder or another NDD. The high prevalence of these disorders justifies a health promotion policy, centred on the child and his or her family. Prevention is based on the early identification of high-risk factors, by informing families and training pregnancy and early childhood professionals, and implementing perinatal prevention protocols for high-risk newborns (antenatal corticosteroid therapy and magnesium sulfate for women at risk of preterm delivery before 32 weeks, developmental care, therapeutic hypothermia for full-term infants with early neonatal encephalopathy presumed to be anoxic)...
March 14, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38489107/sex-differences-in-autistic-youth-born-extremely-preterm
#17
JOURNAL ARTICLE
Tyler C McFayden, Clare Harrop, Kyle Roell, Robert M Joseph, Rebecca C Fry, T Michael O'Shea
PURPOSE: To evaluate sex differences in autistic traits in youth born extremely preterm (EP; 23-27 weeks) who were later diagnosed with autism spectrum disorder (ASD) at 10-years. METHOD: A longitudinal cohort design from the Extremely Low Gestational Age Newborn Study (ELGAN) followed N = 857 EP infants from birth through 10-years. EP infants later diagnosed with ASD (N = 61, 20 females) participated in the study. Group differences were evaluated via inferential and Bayesian statistics (values > 1 suggest evidence for alternate hypothesis) on ASD screeners (M-CHAT at 2-years, SCQ and SRS-2 at 10-years), and gold-standard diagnostic measures (ADOS-2, ADI-R) at 10-years...
March 15, 2024: Journal of Autism and Developmental Disorders
https://read.qxmd.com/read/38486961/antipsychotic-prescribing-patterns-in-children-and-adolescents-attending-australian-general-practice-in-2011-and-2017
#18
JOURNAL ARTICLE
Julie Klau, David Gonzalez-Chica, Melissa Raven, Jon Jureidini
BACKGROUND: Antipsychotics are increasingly prescribed to children and adolescents worldwide, but little is known about reasons for prescribing. We aimed to examine patterns of paediatric antipsychotic prescribing in Australian primary care services in 2011 and 2017, including diagnoses, sociodemographic characteristics, off-label prescribing, and psychotropic co-prescribing. METHODS: Retrospective analysis of electronic health records (EHRs) using a large Australian general practice database (MedicineInsight)...
March 2024: JCPP Adv
https://read.qxmd.com/read/38481463/psychological-impact-of-the-covid-19-pandemic-in-children-with-autism-spectrum-disorder-a-literature-review
#19
REVIEW
Saeed Ahmed, Aunsa Hanif, Ikram Khaliq, Shahana Ayub, Sundas Saboor, Sheikh Shoib, Muhammad Youshay Jawad, Fauzia Arain, Amna Anwar, Irfan Ullah, Sadiq Naveed, Ali Mahmood Khan
Objective : This review summarizes evidence pertaining to the impact of the COVID-19 pandemic on the psychological health of children and adolescents with autism spectrum disorder (ASD). Materials and Methods : An electronic search was conducted using four major databases: PubMed, ScienceDirect, Web of Science, and Google Scholar. Using an umbrella methodology, the reference lists of relevant papers were reviewed, and citation searches were conducted. The study included articles written in English between January 2020 and March 2021 that focused on the psychological health of autistic children and adolescents...
2024: International Journal of Developmental Disabilities
https://read.qxmd.com/read/38481459/autism-spectrum-disorder-comorbidity-and-demographics-in-a-clinical-sample
#20
JOURNAL ARTICLE
Fethiye Kilicaslan, Ali Evren Tufan
Objective: To determine the demographic and clinical characteristics of children followed up with the diagnosis of autism spectrum disorder (ASD) at a tertiary center in Southeeast Turkey. Methods: Children followed up with the diagnosis of ASD at a university hospital child psychiatry clinic between June 2016 and June 2021 were evaluated retrospectively for comorbidities, intellectual functioning and age at diagnosis. Results: In the preschool group, females displayed significantly more frequent cognitive developmental delay...
2024: International Journal of Developmental Disabilities
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