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https://www.readbyqxmd.com/read/27692925/behavioral-difficulties-in-7-year-old-children-in-relation-to-developmental-exposure-to-perfluorinated-alkyl-substances
#1
Youssef Oulhote, Ulrike Steuerwald, Frodi Debes, Pal Weihe, Philippe Grandjean
BACKGROUND: Perfluorinated alkyl substances (PFAS) are suspected endocrine disruptors that are highly persistent and neurotoxic in animals. Human epidemiological studies of exposure-related deviations of children's behaviors are sparse. We assessed the associations between prenatal, 5- and 7-year PFAS exposures and behavioral problem scores in 7-year Faroese children. METHODS: Concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA), perfluorooctane sulfonate (PFOS), and perfluorohexane sulfonic acid (PFHxS) were measured in maternal serum and in serum from children at ages 5 and 7years (n=539, 508, and 491, respectively)...
September 29, 2016: Environment International
https://www.readbyqxmd.com/read/27513883/polycystic-ovary-syndrome-and-psychiatric-disorders-co-morbidity-and-heritability-in-a-nationwide-swedish-cohort
#2
Carolyn E Cesta, Mattias Månsson, Camilla Palm, Paul Lichtenstein, Anastasia N Iliadou, Mikael Landén
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5-15% of reproductive-aged women and characterized by high levels of circulating androgens. Given that androgens have been implicated in the aetiology of several psychiatric disorders, it was hypothesized that women with PCOS have high risk for psychiatric comorbidity. We aimed to investigate this risk amongst women with PCOS, as well as in their siblings, to elucidate if familial factors underlie any potential associations. Using the Swedish national registers, we identified all women diagnosed with PCOS between 1990 and 2013 (n=24,385), their full-siblings (n=25,921), plus matched individuals (1:10/100) from the general population and their full-siblings...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27477860/the-endocrine-society-centennial-no-longer-a-surprise-estrogenic-chemicals-in-a-multitude-of-places
#3
Emilie F Rissman
Nowadays, we are bombarded with information on a large number of endocrine-disrupting chemicals. We hear and read about endocrine-disrupting chemicals on blogs, the web, news stories, television specials, advertisements, and of course scientific articles. Reports claim these ubiquitous compounds are responsible for increased rates of cancer, autism, obesity, hypospadias, and infertility, just to name a few. But it was not always this way. In fact, the scientific study of endocrine-disrupting chemicals is relatively new: a recent PubMed search found a total of 6184 hits for the term, 739 articles in 2015 as compared with 4, 20 years ago in 1995...
August 2016: Endocrinology
https://www.readbyqxmd.com/read/27473827/the-relationship-between-mercury-and-autism-a-comprehensive-review-and-discussion
#4
REVIEW
Janet K Kern, David A Geier, Lisa K Sykes, Boyd E Haley, Mark R Geier
The brain pathology in autism spectrum disorders (ASD) indicates marked and ongoing inflammatory reactivity with concomitant neuronal damage. These findings are suggestive of neuronal insult as a result of external factors, rather than some type of developmental mishap. Various xenobiotics have been suggested as possible causes of this pathology. In a recent review, the top ten environmental compounds suspected of causing autism and learning disabilities were listed and they included: lead, methyl-mercury, polychorinated biphenyls, organophosphate pesticides, organochlorine pesticides, endocrine disruptors, automotive exhaust, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers, and perfluorinated compounds...
September 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27391253/endocrine-disrupting-chemicals-and-reproductive-health
#5
REVIEW
Marya G Zlatnik
This review discusses the evidence linking industrial chemicals to a variety of health and reproductive outcomes. Industrial chemical production has increased over the past 30 to 40 years. Basic science, animal models, and epidemiologic data suggest that certain chemicals may act as endocrine disruptors (substances that interfere with normal hormonal action) and may play an etiologic role in a number of conditions whose incidence has also increased during this same period. These include low birth weight, gestational diabetes, obesity, certain cancers, certain birth defects, and neurodevelopmental disorders such as attention deficit disorder and autism...
July 2016: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/27187441/epigenetic-effect-of-environmental-factors-on-autism-spectrum-disorders
#6
REVIEW
Takeo Kubota, Kazuki Mochizuki
Both environmental factors and genetic factors are involved in the pathogenesis of autism spectrum disorders (ASDs). Epigenetics, an essential mechanism for gene regulation based on chemical modifications of DNA and histone proteins, is also involved in congenital ASDs. It was recently demonstrated that environmental factors, such as endocrine disrupting chemicals and mental stress in early life, can change epigenetic status and gene expression, and can cause ASDs. Moreover, environmentally induced epigenetic changes are not erased during gametogenesis and are transmitted to subsequent generations, leading to changes in behavior phenotypes...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27181180/associations-between-cytokines-endocrine-stress-response-and-gastrointestinal-symptoms-in-autism-spectrum-disorder
#7
Bradley J Ferguson, Sarah Marler, Lily L Altstein, Evon Batey Lee, Micah O Mazurek, Aaron McLaughlin, Eric A Macklin, Erin McDonnell, Daniel J Davis, Anthony M Belenchia, Catherine H Gillespie, Catherine A Peterson, Margaret L Bauman, Kara Gross Margolis, Jeremy Veenstra-VanderWeele, David Q Beversdorf
Many children and adolescents with autism spectrum disorder (ASD) have significant gastrointestinal (GI) symptoms, but the etiology is currently unknown. Some individuals with ASD show altered reactivity to stress and altered immune markers relative to typically-developing individuals, particularly stress-responsive cytokines including tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). The present study examined whether GI symptoms in ASD were associated with increases in cortisol, a stress-associated endocrine marker, and TNF-α and IL-6 in response to stress...
May 12, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27147957/chemicals-nutrition-and-autism-spectrum-disorder-a-mini-review
#8
REVIEW
Takeo Fujiwara, Naho Morisaki, Yukiko Honda, Makiko Sampei, Yukako Tani
The rapid increase of the prevalence of autism spectrum disorder (ASD) suggests that exposure to chemicals may impact the development of ASD. Therefore, we reviewed literature on the following chemicals, nutrient to investigate their association with ASD: (1) smoke/tobacco, (2) alcohol, (3) air pollution, (4) pesticides, (5) endocrine-disrupting chemicals, (6) heavy metals, (7) micronutrients, (8) fatty acid, and (9) parental obesity as a proxy of accumulation of specific chemicals or nutritional status. Several chemical exposures such as air pollution (e...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27003928/burden-of-disease-and-costs-of-exposure-to-endocrine-disrupting-chemicals-in-the-european-union-an-updated-analysis
#9
L Trasande, R T Zoeller, U Hass, A Kortenkamp, P Grandjean, J P Myers, J DiGangi, P M Hunt, R Rudel, S Sathyanarayana, M Bellanger, R Hauser, J Legler, N E Skakkebaek, J J Heindel
A previous report documented that endocrine disrupting chemicals contribute substantially to certain forms of disease and disability. In the present analysis, our main objective was to update a range of health and economic costs that can be reasonably attributed to endocrine disrupting chemical exposures in the European Union, leveraging new burden and disease cost estimates of female reproductive conditions from accompanying report. Expert panels evaluated the epidemiologic evidence, using adapted criteria from the WHO Grading of Recommendations Assessment, Development and Evaluation Working Group, and evaluated laboratory and animal evidence of endocrine disruption using definitions recently promulgated by the Danish Environmental Protection Agency...
July 2016: Andrology
https://www.readbyqxmd.com/read/26994593/deficits-in-voice-and-multisensory-processing-in-patients-with-prader-willi-syndrome
#10
Juliette Salles, Kuzma Strelnikov, Mantoulan Carine, Thuilleaux Denise, Virginie Laurier, Catherine Molinas, Maïthé Tauber, Pascal Barone
Prader-Willi syndrome (PWS) is a rare neurodevelopmental and genetic disorder that is characterized by various expression of endocrine, cognitive and behavioral problems, among which a true obsession for food and a deficit of satiety that leads to hyperphagia and severe obesity. Neuropsychological studies have reported that PWS display altered social interactions with a specific weakness in interpreting social information and in responding to them, a symptom closed to that observed in autism spectrum disorders (ASD)...
May 2016: Neuropsychologia
https://www.readbyqxmd.com/read/26613405/the-plausibility-of-maternal-toxicant-exposure-and-nutritional-status-as-contributing-factors-to-the-risk-of-autism-spectrum-disorders
#11
Johnathan R Nuttall
Recent research suggests the maternal environment may be especially important for the risk of developing autism spectrum disorders (ASD). In particular maternal infections, micronutrient deficiencies, obesity, and toxicant exposures are likely to interact with genetic risk factors to disrupt fetal brain development. Objectives The goal of this paper is to investigate the plausibility of maternal toxicant exposure and nutritional status as causal factors in the development of ASD. Methods This paper reviews current research investigating the hypothesis that maternal toxicant exposure and prenatal micronutrient intake are important modifiable risk factors for ASD...
November 27, 2015: Nutritional Neuroscience
https://www.readbyqxmd.com/read/26541950/acetylcysteine-for-treatment-of-autism-spectrum-disorder-symptoms
#12
Danielle Stutzman, Julie Dopheide
PURPOSE: Successful use of acetylcysteine to control irritability and aggressive behaviors in a hospitalized adolescent patient with autism spectrum disorder (ASD) is described. SUMMARY: A 17-year-old Hispanic male with ASD and intellectual disability was hospitalized for inpatient psychiatric treatment due to impulsive and violent behavior. Despite receiving various medications in the initial weeks of hospitalization, including intramuscular lorazepam and diphenhydramine injections (four days a week on average), the patient continued to exhibit aggressive and unpredictable behaviors...
November 15, 2015: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/26450281/increased-serum-phthalates-mehp-dehp-and-bisphenol-a-concentrations-in-children-with-autism-spectrum-disorder-the-role-of-endocrine-disruptors-in-autism-etiopathogenesis
#13
Fatih Kardas, Ayse Kacar Bayram, Esra Demirci, Leyla Akin, Sevgi Ozmen, Mustafa Kendirci, Mehmet Canpolat, Didem Behice Oztop, Figen Narin, Hakan Gumus, Sefer Kumandas, Huseyin Per
The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0...
April 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/26445284/focal-atrophy-of-the-hypothalamus-associated-with-third-ventricle-enlargement-in-autism-spectrum-disorder
#14
Farah H Wolfe, Guillaume Auzias, Christine Deruelle, Thierry Chaminade
The hypothalamus is a brain structure containing multiple nuclei that mediate essential behavioral, autonomic, and endocrine functions including oxytocin synthesis. Oxytocin is a neuropeptide linked to complex social cognition and behaviors necessary for an effective social interaction. Oxytocinergic system dysfunction has been linked to social deficits in autism spectrum disorders (ASD). Limited studies have been carried out on the hypothalamus because of its small size and methodological constraints in current technologies...
December 2, 2015: Neuroreport
https://www.readbyqxmd.com/read/26364046/an-epigenetic-basis-for-autism-spectrum-disorder-risk-and-oral-contraceptive-use
#15
Kim Strifert
In the United States 1 in 68 children are diagnosed with autism spectrum disorder (ASD). Although the etiology is unknown, many scientists believe ASD is caused by a combination of genetic and environmental factors and/or epigenetic factors. The widespread use of oral contraceptives is one environmental risk factor that has been greatly overlooked in the biomedical literature. Oral contraceptives, synthetic hormones created to imitate natural human hormones and disrupt endogenous endocrine function to inhibit pregnancy, may be causing the harmful neurodevelopmental effects that result in the increased prevalence of ASD...
December 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26108271/phthalate-concentrations-in-house-dust-in-relation-to-autism-spectrum-disorder-and-developmental-delay-in-the-childhood-autism-risks-from-genetics-and-the-environment-charge-study
#16
Claire Philippat, Deborah H Bennett, Paula Krakowiak, Melissa Rose, Hyun-Min Hwang, Irva Hertz-Picciotto
BACKGROUND: Phthalates are endocrine-disrupting chemicals that influence thyroid hormones and sex steroids, both critical for brain development. AIM: We studied phthalate concentrations in house dust in relation to the risks of developing autism spectrum disorder (ASD) or developmental delay (DD). METHODS: Participants were a subset of children from the CHARGE (CHildhood Autism Risks from Genetics and the Environment) case-control study. ASD and DD cases were identified through the California Department of Developmental Services system or referrals; general population controls were randomly sampled from state birth files and frequency-matched on age, sex, and broad geographic region to ASD cases...
2015: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/26098633/mecp2-affects-skeletal-muscle-growth-and-morphology-through-non-cell-autonomous-mechanisms
#17
Valentina Conti, Anna Gandaglia, Francesco Galli, Mario Tirone, Elisa Bellini, Lara Campana, Charlotte Kilstrup-Nielsen, Patrizia Rovere-Querini, Silvia Brunelli, Nicoletta Landsberger
Rett syndrome (RTT) is an autism spectrum disorder mainly caused by mutations in the X-linked MECP2 gene and affecting roughly 1 out of 10.000 born girls. Symptoms range in severity and include stereotypical movement, lack of spoken language, seizures, ataxia and severe intellectual disability. Notably, muscle tone is generally abnormal in RTT girls and women and the Mecp2-null mouse model constitutively reflects this disease feature. We hypothesized that MeCP2 in muscle might physiologically contribute to its development and/or homeostasis, and conversely its defects in RTT might alter the tissue integrity or function...
2015: PloS One
https://www.readbyqxmd.com/read/26066795/influence-of-low-level-prenatal-exposure-to-pcdd-fs-and-pcbs-on-empathizing-systemizing-and-autistic-traits-results-from-the-duisburg-birth-cohort-study
#18
Nikola Nowack, Jürgen Wittsiepe, Monika Kasper-Sonnenberg, Michael Wilhelm, Axel Schölmerich
BACKGROUND: Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are assumed to act as endocrine disruptor chemicals. Prenatal exposure to these pollutants might influence fetal steroid hormone levels, which are thought to be related to sex-typical development and autistic traits. OBJECTIVES: We examined associations of prenatal levels of PCDD/Fs and PCBs with autism traits and sex-typical behaviour in childhood. METHODS: We measured levels of PCDD/Fs and PCBs in maternal blood samples during pregnancy using gas chromatography/high-resolution mass spectrometry...
2015: PloS One
https://www.readbyqxmd.com/read/26036743/-sentieri-studies-scientific-evidence-and-lack-of-use-for-prevention
#19
Agostino Di Ciaula, Carlo Romagnoli, Ruggero Ridolfi
Studies from SENTIERI project have been crucial to show high-risk levels (mortality and morbidity) in communities living close to polluted sites. Despite the presence of some methodological limits, these studies represent a strong invitation towards primary prevention, also considering a possible underestimation of the health risk. The same pollutants responsible for the results showed in the SENTIERI studies are able to induce diseases (i.e., endocrine-metabolic diseases, spontaneous abortion, foetal malformations, autism, neurologic diseases) still unevaluated or not evaluable considering the actually available tools...
March 2015: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/25964215/hormonal-programming-of-rat-social-play-behavior-standardized-techniques-will-aid-synthesis-and-translation-to-human-health
#20
REVIEW
Bevin E Blake, Krista A McCoy
Early social behaviors like juvenile play are important for normal cognitive and social development. Deficits in these behaviors are associated with neurodevelopmental disorders, such as autism. Rat juvenile rough-and-tumble play is a useful behavioral biomarker of neurodevelopment, and is sensitive to chemical factors such as pre and neonatal hormones. Despite a rich body of literature characterizing hormonal programming of rodent juvenile play, the physiological mechanisms that regulate the organization of play behavior are not well characterized...
August 2015: Neuroscience and Biobehavioral Reviews
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