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https://www.readbyqxmd.com/read/29529521/prenatal-dexamethasone-treatment-in-the-context-of-at-risk-cah-pregnancies-long-term-behavioral-and-cognitive-outcome
#1
Leif Karlsson, Anna Nordenström, Tatja Hirvikoski, Svetlana Lajic
Dexamethasone (DEX) is used to prevent prenatal virilization in female fetuses with congenital adrenal hyperplasia (CAH). Since treatment has to be started before the genotype of the fetus is known, 7 out of 8 fetuses will be exposed to DEX without benefit. Previously, we have observed negative effects on cognition and behavior in DEX treated children. Here we evaluated neuropsychological functions, psychopathology and autistic traits in non-CAH DEX-treated adults exposed during the first trimester of fetal life (duration 6...
March 1, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27460188/no-relationship-between-prenatal-androgen-exposure-and-autistic-traits-convergent-evidence-from-studies-of-children-with-congenital-adrenal-hyperplasia-and-of-amniotic-testosterone-concentrations-in-typically-developing-children
#2
Karson T F Kung, Debra Spencer, Vickie Pasterski, Sharon Neufeld, Vivette Glover, Thomas G O'Connor, Peter C Hindmarsh, Ieuan A Hughes, Carlo L Acerini, Melissa Hines
BACKGROUND: There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. METHODS: A parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies...
December 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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