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Autism pcos

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https://www.readbyqxmd.com/read/28531286/is-foetal-hyperexposure-to-androgens-a-cause-of-pcos
#1
Panagiota Filippou, Roy Homburg
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. The pathophysiology of this syndrome is still not completely understood but recent evidence suggests that the intra-uterine environment may be a key factor in the pathogenesis of PCOS, in particular, hyperexposure of the foetus to androgens. High concentrations of maternal serum testosterone during pregnancy have been shown to influence behaviour during childhood, the prevalence of autism disorders and anti-Mullerian hormone (AMH) concentrations in adolescence...
May 20, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28383189/maternal-hirsutism-and-autism-spectrum-disorders-in-offspring
#2
Brian K Lee, Stefan Arver, Linnea Widman, Renee M Gardner, Cecilia Magnusson, Christina Dalman, Kyriaki Kosidou
Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD...
April 6, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27889187/maternal-polycystic-ovary-syndrome-and-risk-for-attention-deficit-hyperactivity-disorder-in-the-offspring
#3
Kyriaki Kosidou, Christina Dalman, Linnea Widman, Stefan Arver, Brian K Lee, Cecilia Magnusson, Renee M Gardner
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood neurodevelopmental disorder, and boys are two to three times more likely to develop ADHD. Maternal polycystic ovary syndrome (PCOS), a common metabolic disorder associated with excess circulating androgens, has been associated with increased risk for autism spectrum disorder in the offspring. In this study, we aimed to investigate whether maternal PCOS increases the risk for ADHD in the offspring...
October 6, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27513883/polycystic-ovary-syndrome-and-psychiatric-disorders-co-morbidity-and-heritability-in-a-nationwide-swedish-cohort
#4
Carolyn E Cesta, Mattias Månsson, Camilla Palm, Paul Lichtenstein, Anastasia N Iliadou, Mikael Landén
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5-15% of reproductive-aged women and characterized by high levels of circulating androgens. Given that androgens have been implicated in the aetiology of several psychiatric disorders, it was hypothesized that women with PCOS have high risk for psychiatric comorbidity. We aimed to investigate this risk amongst women with PCOS, as well as in their siblings, to elucidate if familial factors underlie any potential associations. Using the Swedish national registers, we identified all women diagnosed with PCOS between 1990 and 2013 (n=24,385), their full-siblings (n=25,921), plus matched individuals (1:10/100) from the general population and their full-siblings...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/17462645/elevated-rates-of-testosterone-related-disorders-in-women-with-autism-spectrum-conditions
#5
COMPARATIVE STUDY
Erin Ingudomnukul, Simon Baron-Cohen, Sally Wheelwright, Rebecca Knickmeyer
The androgen theory of autism proposes that autism spectrum conditions (ASC) are in part due to elevated fetal testosterone (FT) levels, which are positively correlated with a number of autistic traits and inversely correlated with social development and empathy. A medical questionnaire was completed by n=54 women with ASC, n=74 mothers of children with ASC, and n=183 mothers of typically developing children to test whether women with ASC have an increased rate of testosterone-related medical conditions, and to see whether mothers of children with ASC show similar abnormalities, as part of the 'broader autism phenotype'...
May 2007: Hormones and Behavior
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