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Antimicrobial peptides

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https://www.readbyqxmd.com/read/29456275/antimicrobial-packaging-based-on-%C3%A9-polylysine-bioactive-film-for-the-control-of-mycotoxigenic-fungi-in-vitro-and-in-bread
#1
C Luz, J Calpe, F Saladino, Fernando B Luciano, M Fernandez-Franzón, J Mañes, G Meca
ɛ-Poly-l-lysine (ɛ-PL) is a cationic peptide with a broad-spectrum antimicrobial activity. This study investigates the use of ɛ-PL as natural antimicrobial to inhibit fungal growth and to reduce aflatoxins (AFs) production. Antifungal activity of starch biofilms with different concentrations of ɛ-Poly-l-lysine (ɛ-PL) was determined in solid medium against Aspergillus parasiticus (AFs producer) and Penicillium expansum . Then, biofilms were tested as antimicrobial devices for the preservation of bread loaf inoculated with A...
January 2018: Journal of Food Processing and Preservation
https://www.readbyqxmd.com/read/29455278/a-review-of-the-design-and-modification-of-lactoferricins-and-their-derivatives
#2
Ya Hao, Na Yang, Da Teng, Xiumin Wang, Ruoyu Mao, Jianhua Wang
Lactoferricin (Lfcin), a multifunction short peptide with a length of 25 residues, is derived from the whey protein lactoferrin by acidic pepsin hydrolysis. It has potent nutritional enhancement, antimicrobial, anticancer, antiviral, antiparasitic, and anti-inflammatory activities. This review describes the research advantages of the above biological functions, with attention to the molecular design and modification of Lfcin. In this examination of design and modification studies, research on the identification of Lfcin active derivatives and crucial amino acid residues is also reviewed...
February 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29454031/expression-and-characterization-of-recombinant-rattusin-an-%C3%AE-defensin-related-peptide-with-a-homodimeric-scaffold-formed-by-intermolecular-disulfide-exchanges
#3
Sehyeon Ji, Hyosuk Yun, Gwansik Park, Hye Jung Min, Chul Won Lee
Rattusin is an α-defensin-related peptide isolated from the small intestine of rats. The primary sequence of linear rattusin is composed of 31 amino acids containing five cysteines with a unique spacing pattern. It forms a homodimeric scaffold in which the primary structure occurs in an antiparallel fashion formed by five intermolecular disulfide (SS) bonds. Rattusin is a highly potent antibiotic, which not only exhibits broad-spectrum antimicrobial activity, but also maintains its antimicrobial activity at physiological salt concentrations...
February 14, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29453967/discovery-of-anti-viral-molecules-and-their-vital-functions-in-bombyx-mori
#4
REVIEW
Peng Lü, Ye Pan, Yanhua Yang, Feifei Zhu, Chengjun Li, Qin Yao, Keping Chen
The silkworm Bombyx mori (B. mori), a lepidopteran model organism, has become an important model for molecular biology researches with its genome completely sequenced. Silkworms confront different types of virus diseases, mainly including those caused by Bombyx mori nucleopolyhedrovirus (BmNPV), Bombyx mori densovirus type 1 (BmDNV-1), Bombyx mori bidesovirus (BmBDV) which was termed as Bombyx mori densovirus type 2 (BmDNV-2) or Bombyx mori parvo-like virus (BmPLV) before in sericulture. B. mori offers excellent models to study the molecular mechanisms of insect innate immune responses to viruses...
February 14, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29453279/il-12-il-18-cosignaling-in-human-macrophages-and-lung-epithelial-cells-activates-cathelicidin-and-autophagy-inhibiting-intracellular-mycobacterial-growth
#5
Rui Yang, Enzhuo Yang, Ling Shen, Robert L Modlin, Hongbo Shen, Zheng W Chen
The ability of Mycobacterium tuberculosis to block host antimicrobial responses in infected cells provides a key mechanism for disease pathogenesis. The immune system has evolved to overcome this blockade to restrict the infection, but it is not clear whether two key innate cytokines (IL-12/IL-18) involved in host defense can enhance antimycobacterial mechanisms. In this study, we demonstrated that the combination of IL-12 and IL-18 triggered an antimicrobial response against mycobacteria in infected macrophages (THP-1 and human primary monocyte-derived macrophages) and pulmonary epithelial A549 cells...
February 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29452934/evaluation-of-leader-peptides-that-affect-the-secretory-ability-of-a-multiple-bacteriocin-transporter-enkt
#6
Hirotoshi Sushida, Naoki Ishibashi, Takeshi Zendo, Pongtep Wilaipun, Vichien Leelawatcharamas, Jiro Nakayama, Kenji Sonomoto
EnkT is a novel ATP-binding cassette (ABC) transporter responsible for secretion of four bacteriocins, enterocins NKR-5-3A, C, D, and Z (Ent53A, C, D, and Z), produced by Enterococcus faecium NKR-5-3. It is generally recognized that the secretion of a bacteriocin requires a dedicated ABC transporter, although molecular mechanisms of this secretion are yet to be revealed. In order to characterize the unique ability of EnkT to secrete multiple bacteriocins, the role of N-terminal leader peptides of bacteriocin precursors was evaluated using Ent53C precursor as a model...
February 13, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29452617/imaging-of-spondylodiscitis
#7
REVIEW
Meera Raghavan, Elena Lazzeri, Christopher J Palestro
Spondylodiscitis is an infection of the vertebral body or disc and may also involve the epidural space, posterior elements, and paraspinal soft tissues. It is a cause of morbidity and mortality, and warrants early diagnosis and prompt treatment. Diagnosis can be difficult because of nonspecific signs and symptoms. Magnetic resonance imaging is sensitive and specific and is the imaging modality of choice for spondylodiscitis. Gadolinium contrast can show the extent of soft tissue and bone phlegmon and abscess...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452081/chronic-nosema-ceranae-infection-inflicts-comprehensive-and-persistent-immunosuppression-and-accelerated-lipid-loss-in-host-apis-mellifera-honey-bees
#8
Wenfeng Li, Yanping Chen, Steven C Cook
Nosema ceranae is an intracellular microsporidian parasite of the Asian honey bee Apis cerana and the European honey bee Apis mellifera. Until relatively recently, A. mellifera honey bees were naïve to N. ceranae infection. Symptoms of nosemosis, or Nosema disease, in the infected hosts include immunosuppression, damage to gut epithelium, nutrient and energetic stress, precocious foraging and reduced longevity of infected bees. Links remain unclear between immunosuppression, the symptoms of nutrient and energetic stress, and precocious foraging behavior of hosts...
February 13, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29450858/in-source-reduction-of-disulfide-bonded-peptides-monitored-by-ion-mobility-mass-spectrometry
#9
Bradley B Stocks, Jeremy E Melanson
Many peptides with antimicrobial activity and/or therapeutic potential contain disulfide bonds as a means to enhance stability, and their quantitation is often performed using electrospray ionization mass spectrometry (ESI-MS). Disulfides can be reduced during ESI under commonly used instrument conditions, which has the potential to hinder accurate peptide quantitation. We demonstrate that this in-source reduction (ISR) is predominantly observed for peptides infused from acidic solutions and subjected to elevated ESI voltages (3-4 kV)...
February 15, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29449834/peptidoglycan-recognition-protein-3-does-not-alter-the-outcome-of-pneumococcal-pneumonia-in-mice
#10
Anshu Shrivastav, Alexander N Dabrowski, Claudia Conrad, Nelli Baal, Holger Hackstein, Stephanie Plog, Kristina Dietert, Achim D Gruber, Philippe D N'Guessan, Sahar Aly, Norbert Suttorp, Janine Zahlten
Pneumococci frequently cause community-acquired pneumonia, a disease with high mortality rates, particularly in young children and in the elderly. Endogenous antimicrobial peptides and proteins such as PGLYRP3 may contribute to the progression and outcome of this disease. Since increasing antibiotic resistant strains occur all over the world, these endogenous antimicrobial molecules are interesting new targets for future therapies. In this study, the expression pattern of PGLYRP3 was analyzed in alveolar epithelial cells, alveolar macrophages and neutrophils...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29448216/development-of-an-indolicidin-derived-peptide-by-reducing-membrane-perturbation-to-decrease-cytotoxicity-and-maintain-gene-delivery-ability
#11
Ching-Wei Tsai, Ze-Wei Lin, Wen-Fang Chang, Yi-Fan Chen, Wei-Wen Hu
Indolicidin (IL) is a cationic antimicrobial peptide and our previous study has demonstrated its potential as a cell penetrating peptide (CPP) to promote gene delivery. However, the cytotoxicity of IL arisen from its membrane perturbation capacity may restrict its clinical application. To promote gene delivery safety and efficiency, an almost mirror-symmetric IL derivative, SAP10 (RRWKFFPWRR-CONH 2 ), was designed in this study. All-atom molecular dynamics (MD) simulations were performed to understand the association between SAP10 and model lipid bilayers...
February 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29447842/neutrophils-drive-type-i-interferon-production-and-autoantibodies-in-wiskott-aldrich-syndrome
#12
K E Cervantes-Luevano, N Caronni, M C Castiello, E Fontana, G Piperno, A Naseem, P Uva, M Bosticardo, G E Marcovecchio, L D Notarangelo, M P Cicalese, A Aiuti, A Villa, F Benvenuti
BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency caused by mutations in WASp, a key regulator of cytoskeletal dynamics in hematopoietic cells. A high proportion of patients develop autoimmunity due to a breakdown in T and B cell tolerance. Moreover, excessive production of type-I interferon by plasmacytoid DCs contribute to autoimmune signs, however, the factors that triggers excessive innate activation have not been defined. OBJECTIVE: Neutrophils extracellular traps (NETs) emerged as major initiating factors in diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
February 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29446954/mechanism-of-initial-stage-of-pore-formation-induced-by-antimicrobial-peptide-magainin-2
#13
Moynul Hasan, Mohammad Abu Sayem Karal, Victor Levadnyy, Masahito Yamazaki
Antimicrobial peptide magainin 2 forms pores in lipid bilayers, a property that is considered the main cause of its bactericidal activity. Recent data suggest that tension or stretching of the inner monolayer plays an important role in magainin 2-induced pore formation in lipid bilayers. Here, to elucidate the mechanism of magainin 2-induced pore formation, we investigated the effect on pore formation of asymmetric lipid distribution in two monolayers. First, we developed a method to prepare giant unilamellar vesicles (GUVs) composed of dioleoylphosphatidylglycerol (DOPG), dioleoylphosphatidylcholine (DOPC), and lyso-PC in the inner monolayer and of DOPG/DOPC in the outer monolayer...
February 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29446150/antimicrobial-peptide-gene-expression-in-periodontitis-patients-a-pilot-study
#14
M L Jourdain, L Pierrard, L Kanagaratnam, F Velard, J Sergheraert, B Lefèvre, S C Gangloff, J Braux
AIM: Antimicrobial peptides (AMPs) are one of the most active components of innate immunity and have characteristics that could place them at the heart of the pathogenesis of periodontal disease. This study investigated differences in the expression of AMP coding genes obtained using a simple harvesting technique, gingival smear, between two groups of patients: chronic periodontitis subjects vs healthy ones. MATERIALS AND METHODS: Twenty-three patients were enrolled in two groups: 12 were diagnosed with moderate or severe generalized chronic periodontitis and 11 were diagnosed as clinically healthy...
February 15, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29444846/differential-immune-gene-expression-in-sperm-storage-organs-of-leaf-cutting-ants
#15
Sarah Chérasse, Boris Baer, Morten Schiøtt, Jacobus J Boomsma
Leaf-cutting ant queens mate with multiple males during a single nuptial flight and store sperm for up to two decades. During mating, males transfer sperm from their accessory testes to the queen bursa copulatrix from where it enters the spermatheca, an insect sperm storage organ that has become highly specialised in long-lived ant queens who never re-mate later in life. Long-term storage without the possibility to obtain new sperm creates an immune defence dilemma, because recognition of non-self cells eliminates infections but may also target irreplaceable sperm and reduce lifetime reproductive success...
February 14, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29443886/antibacterial-peptides-in-dermatology-strategies-for-evaluation-of-allergic-potential
#16
REVIEW
Milena Deptuła, Anna Wardowska, Maria Dzierżyńska, Sylwia Rodziewicz-Motowidło, Michał Pikuła
During recent decades, the market for peptide-based drugs, including antimicrobial peptides, has vastly extended and evolved. These drugs can be useful in treatment of various types of disorders, e.g., cancer, autoimmune diseases, infections, and non-healing wounds. Although peptides are less immunogenic than other biologic therapeutics, they can still induce immune responses and cause allergies. It is important to evaluate the immunogenic and allergic potential of peptides before they are forwarded to the expensive stages of clinical trials...
February 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29441657/towards-sequence-controlled-antimicrobial-polymers-effect-of-polymer-block-order-on-antimicrobial-activity
#17
Peter R Judzewitsch, Thuy-Khanh Nguyen, Sivaprakash Shanmugam, Edgar H H Wong, Cyrille Andre Jean Marie Boyer
The biological effects of sequence control in synthetic antimicrobial polymers are currently not well understood. As such, we investigate the antimicrobial effects of monomer distribution within linear high-order multiblock copolymers which were made in a one-pot synthesis approach via photoinduced electron transfer-reversible addition-fragmentation chain transfer polymerisation (PET-RAFT). Through different combinations of monomer/polymer block order, the antimicrobial and haemolytic activities are tuneable in a manner comparable to antimicrobial peptides...
February 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29440355/the-antimicrobial-peptide-cramp-is-essential-for-colon-homeostasis-by-maintaining-microbiota-balance
#18
Teizo Yoshimura, Mairi H McLean, Amiran K Dzutsev, Xiaohong Yao, Keqiang Chen, Jiaqiang Huang, Wanghua Gong, Jiamin Zhou, Yi Xiang, Jonathan H Badger, Colm O'hUigin, Vishal Thovarai, Lino Tessarollo, Scott K Durum, Giorgio Trinchieri, Xiu-Wu Bian, Ji Ming Wang
Commensal bacteria are critical for physiological functions in the gut, and dysbiosis in the gut may cause diseases. In this article, we report that mice deficient in cathelin-related antimicrobial peptide (CRAMP) were defective in the development of colon mucosa and highly sensitive to dextran sulfate sodium (DSS)-elicited colitis, as well as azoxymethane-mediated carcinogenesis. Pretreatment of CRAMP-/-mice with antibiotics markedly reduced the severity of DSS-induced colitis, suggesting CRAMP as a limiting factor on dysbiosis in the colon...
February 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29439566/incorporation-of-non-proteinogenic-amino-acids-in-class-i-and-ii-lanti-biotics
#19
Nidhi Kakkar, Jessica G Perez, Wenshe R Liu, Michael C Jewett, Wilfred A van der Donk
Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether crosslinks formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin that contain non-proteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement recent alternative approaches to incorporate non-proteinogenic amino acids into lantibiotics...
February 13, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29436993/the-modification-and-design-of-antimicrobial-peptide
#20
Yidan Gao, Hengtong Fang, Lu Fang, Dawei Liu, Jinsong Liu, Menghan Su, Zhi Fang, Wenzhi Ren, Huping Jiao
The antimicrobial peptides (AMPs) are a group of unique naturally occurring anti-microbial compounds with around 50 amino acids. It represents promising therapeutic agents to the infectious disease without concerning about drug resistance. However, commercial development of these peptides for even the simplest application has been hindered by the limitations of sources, instability, toxicity and bioavailability. To improve the properties of the artificial synthesized AMPs, the modification and design are the hotspots of the AMPs research...
February 13, 2018: Current Pharmaceutical Design
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