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https://www.readbyqxmd.com/read/27895066/protocol-of-the-swiss-longitudinal-cohort-study-swicos-in-rural-switzerland
#1
Andreas W Schoenenberger, Franco Muggli, Gianfranco Parati, Augusto Gallino, Georg Ehret, Paolo M Suter, Renate Schoenenberger-Berzins, Therese J Resink, Paul Erne
INTRODUCTION: Increased longevity and consequent major changes in demographics and population lifestyles necessitate new approaches to reduce the burden of ageing-related diseases (including cardiovascular disease) and maintain an optimal quality of life. This study aims to examine and longitudinally follow health status and disease risk factors in a Swiss rural cohort, evaluating all health-related research and practice disciplines to assure development of new implementable and successful preventive strategies for healthy ageing...
November 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/27876787/deep-phenotyping-unveils-hidden-traits-and-genetic-relations-in-subtle-mutants
#2
Adriana San-Miguel, Peri T Kurshan, Matthew M Crane, Yuehui Zhao, Patrick T McGrath, Kang Shen, Hang Lu
Discovering mechanistic insights from phenotypic information is critical for the understanding of biological processes. For model organisms, unlike in cell culture, this is currently bottlenecked by the non-quantitative nature and perceptive biases of human observations, and the limited number of reporters that can be simultaneously incorporated in live animals. An additional challenge is that isogenic populations exhibit significant phenotypic heterogeneity. These difficulties limit genetic approaches to many biological questions...
November 23, 2016: Nature Communications
https://www.readbyqxmd.com/read/27870647/meg-may-reveal-hidden-population-of-spikes-in-epilepsy-with-porencephalic-cyst-encephalomalacia
#3
Yosuke Kakisaka, Zhong I Wang, Sumiya Shibata, Yoko Takahashi, John C Mosher, Andreas V Alexopoulos, Richard C Burgess
Porencephalic cyst/encephalomalacia (PC/E) is often associated with intractable epilepsy. A Limited number of studies reported Magnetoencephalography (MEG)'s potential to help construct treatment strategy for epilepsies associated with PC/E. We present here simultaneous EEG and MEG findings in three adult patients with pediatric-onset epilepsy due to PC/E. There were two types of spikes: one type was detected by MEG only (EEG-/MEG+), and the other detected by both EEG and MEG (EEG+/MEG+). Both types were seen in all three cases...
November 16, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27865877/cough-in-the-athlete-chest-guideline-and-expert-panel-report
#4
Louis-Philippe Boulet, Julie Turmel, Richard S Irwin
BACKGROUND: Cough is a common symptom experienced by athletes, particularly after exercise. We performed a systematic review to assess in this population: 1) the main etiologies of acute and recurrent cough, either exercise-induced or not; 2) how it is assessed; and 3) how cough is treated in this population. From the systematic review, suggestions for management were developed. METHOD: ology: This review was done according to the CHEST methodological guidelines and GRADE framework up to April 2015...
November 16, 2016: Chest
https://www.readbyqxmd.com/read/27842543/design-of-the-indian-nca-study-indian-national-collaboration-on-aids-a-cluster-randomized-trial-to-evaluate-the-effectiveness-of-integrated-care-centers-to-improve-hiv-outcomes-among-men-who-have-sex-with-men-and-persons-who-inject-drugs-in-india
#5
Sunil S Solomon, Gregory M Lucas, David D Celentano, Allison M McFall, Elizabeth Ogburn, Lawrence H Moulton, Aylur K Srikrishnan, M Suresh Kumar, Santhanam Anand, Suniti Solomon, Shruti H Mehta
BACKGROUND: Globally, men who have sex with men and people who inject drugs remain disproportionately affected by HIV, but they have not been the focus of prevention and treatment interventions in many resource-limited settings. METHODS/DESIGN: This cluster-randomized trial (conducted from June 2012 to June 2017), evaluates whether single-venue, integrated delivery of core HIV services to vulnerable high-risk populations improves service utilization and consequently, HIV testing and other outcomes along the HIV care continuum...
November 14, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27842492/genetic-diversity-and-population-structure-analysis-to-construct-a-core-collection-from-a-large-capsicum-germplasm
#6
Hea-Young Lee, Na-Young Ro, Hee-Jin Jeong, Jin-Kyung Kwon, Jinkwan Jo, Yeaseong Ha, Ayoung Jung, Ji-Woong Han, Jelli Venkatesh, Byoung-Cheorl Kang
BACKGROUND: Conservation of genetic diversity is an essential prerequisite for developing new cultivars with desirable agronomic traits. Although a large number of germplasm collections have been established worldwide, many of them face major difficulties due to large size and a lack of adequate information about population structure and genetic diversity. Core collection with a minimum number of accessions and maximum genetic diversity of pepper species and its wild relatives will facilitate easy access to genetic material as well as the use of hidden genetic diversity in Capsicum...
November 14, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27830640/anxiety-depression-suicidal-ideation-and-stressful-life-events-in-non-cardiac-adolescent-chest-pain-a-comparative-study-about-the-hidden-part-of-the-iceberg
#7
Kayi Eliacik, Ali Kanik, Nurullah Bolat, Hilal Mertek, Baris Guven, Ulas Karadas, Buket Dogrusoz, Ali Rahmi Bakiler
Chest pain in adolescents is rarely associated with cardiac disease. Adolescents with medically unexplained chest pain usually have high levels of anxiety and depression. Psychological stress may trigger non-cardiac chest pain. This study evaluated risk factors that particularly characterise adolescence, such as major stressful events, in a clinical population. The present study was conducted on 100 adolescents with non-cardiac chest pain and 76 control subjects. Stressful life events were assessed by interviewing patients using a 36-item checklist, along with the Children's Depression Inventory and Spielberger's State-Trait Anxiety Inventory for children, in both groups...
November 10, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27819220/genomic-and-genetic-variability-of-six-chicken-populations-using-single-nucleotide-polymorphism-and-copy-number-variants-as-markers
#8
M G Strillacci, M C Cozzi, E Gorla, F Mosca, F Schiavini, S I Román-Ponce, F J Ruiz López, A Schiavone, M Marzoni, S Cerolini, A Bagnato
Genomic and genetic variation among six Italian chicken native breeds (Livornese, Mericanel della Brianza, Milanino, Bionda Piemontese, Bianca di Saluzzo and Siciliana) were studied using single nucleotide polymorphism (SNP) and copy number variants (CNV) as markers. A total of 94 DNA samples genotyped with Axiom® Genome-Wide Chicken Genotyping Array (Affymetrix) were used in the analyses. The results showed the genetic and genomic variability occurring among the six Italian chicken breeds. The genetic relationship among animals was established with a principal component analysis...
November 7, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27815131/sensory-coding-and-cognitive-processing-of-sound-in-veterans-with-blast-exposure
#9
Scott Bressler, Hannah Goldberg, Barbara Shinn-Cunningham
Recent anecdotal reports from VA audiology clinics as well as a few published studies have identified a sub-population of Service Members seeking treatment for problems communicating in everyday, noisy listening environments despite having normal to near-normal hearing thresholds. Because of their increased risk of exposure to dangerous levels of prolonged noise and transient explosive blast events, communication problems in these soldiers could be due to either hearing loss (traditional or "hidden") in the auditory sensory periphery or from blast-induced injury to cortical networks associated with attention...
November 2, 2016: Hearing Research
https://www.readbyqxmd.com/read/27800156/sarcopenia-and-sarcopenic-obesity-do-they-predict-inferior-oncologic-outcomes-after-gastrointestinal-cancer-surgery
#10
REVIEW
Kimberly L Mei, John A Batsis, Jeannine B Mills, Stefan D Holubar
Sarcopenia, or loss of skeletal muscle mass and quality, has been studied as part of aging and adverse health outcomes in elderly patients but has only recently been evaluated as a separate condition in cancer patients and important indicator of adverse outcomes. Currently, its definition and method of assessment are still being debated. Sarcopenia within an increasingly obese population has led to a subgroup with sarcopenic obesity, at even higher risk of adverse outcomes. Yet, sarcopenia often goes undiagnosed in these patients, hidden beneath higher body mass index...
2016: Perioperative Medicine
https://www.readbyqxmd.com/read/27776437/statistical-performance-analysis-of-data-driven-neural-models
#11
Dean R Freestone, Kelvin J Layton, Levin Kuhlmann, Mark J Cook
Data-driven model-based analysis of electrophysiological data is an emerging technique for understanding the mechanisms of seizures. Model-based analysis enables tracking of hidden brain states that are represented by the dynamics of neural mass models. Neural mass models describe the mean firing rates and mean membrane potentials of populations of neurons. Various neural mass models exist with different levels of complexity and realism. An ideal data-driven model-based analysis framework will incorporate the most realistic model possible, enabling accurate imaging of the physiological variables...
June 9, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/27773987/how-genes-modulate-patterns-of-aging-related-changes-on-the-way-to-100-biodemographic-models-and-methods-in-genetic-analyses-of-longitudinal-data
#12
Anatoliy I Yashin, Konstantin G Arbeev, Deqing Wu, Liubov Arbeeva, Alexander Kulminski, Irina Kulminskaya, Igor Akushevich, Svetlana V Ukraintseva
BACKGROUND AND OBJECTIVE: To clarify mechanisms of genetic regulation of human aging and longevity traits, a number of genome-wide association studies (GWAS) of these traits have been performed. However, the results of these analyses did not meet expectations of the researchers. Most detected genetic associations have not reached a genome-wide level of statistical significance, and suffered from the lack of replication in the studies of independent populations. The reasons for slow progress in this research area include low efficiency of statistical methods used in data analyses, genetic heterogeneity of aging and longevity related traits, possibility of pleiotropic (e...
2016: North American Actuarial Journal: NAAJ
https://www.readbyqxmd.com/read/27770479/hidden-mechanisms-beyond-the-pupillary-block-in-acute-angle-closure-ultrasound-biomicroscopic-study
#13
Yanin Suwan, Sunpong Jiamsawad, Wasu Supakontanasan, Chaiwat Teekhasaenee
BACKGROUND: To evaluate the mechanisms of acute angle-closure (AAC) other than the pupillary block using ultrasound biomicroscopy DESIGN: Retrospective chart review. PARTICIPANTS: All patients who were diagnosed with AAC in Ramathibodi Hospital, Bangkok, Thailand, between June 2011 and February 2015 were enrolled. METHODS: 72 patients who were diagnosed with AAC underwent a detailed ocular examination. The diagnosed mechanism of AAC was confirmed by UBM and ocular biometry...
October 22, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27762396/revealing-deactivation-pathways-hidden-in-time-resolved-photoelectron-spectra
#14
Matthias Ruckenbauer, Sebastian Mai, Philipp Marquetand, Leticia González
Time-resolved photoelectron spectroscopy is commonly employed with the intention to monitor electronic excited-state dynamics occurring in a neutral molecule. With the help of theory, we show that when excited-state processes occur on similar time scales the different relaxation pathways are completely obscured in the total photoionization signal recorded in the experiment. Using non-adiabatic molecular dynamics and Dyson norms, we calculate the photoionization signal of cytosine and disentangle the transient contributions originating from the different deactivation pathways of its tautomers...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27759764/a-simple-biologically-sound-and-potentially-useful-working-classification-of-chagas-disease-vectors
#15
Fernando Abad-Franch
Current working classifications of Chagas disease vectors rely on a loose mix-up of biological and operational matters. They are therefore confusing and ineffective. I propose a very simple classification that makes biological sense and can be operationally useful. It considers a four-level hierarchy of species (which can be native or non-native); populations (either wild or non-wild); infestation foci (natural, domestic or peridomestic); and individual bugs (which can be solitary house-invaders or part of a hidden infestation focus)...
October 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27755742/counteracting-effects-of-a-non-native-prey-on-the-demography-of-a-native-predator-culminate-in-positive-population-growth
#16
Christopher E Cattau, Robert J Fletcher, Brian E Reichert, Wiley M Kitchens
Identifying impacts of non-native species on native populations is central to conservation and ecology. While effects of non-native predators on native prey populations have recently received much attention, impacts of introduced prey on native predator populations are less understood. Non-native prey can influence predator behavior and demography through direct and indirect pathways, yet quantitative assessments of the relative impacts of multiple, potentially counteracting, effects on native predator population growth remain scarce...
October 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27752368/challenges-in-diagnosis-and-treatment-of-lung-cancer-in-people-with-intellectual-disabilities-current-state-of-knowledge
#17
Daniel Satgé, Emmanuelle Kempf, Jean-Bernard Dubois, Motoi Nishi, Jean Trédaniel
As the life expectancy of people with intellectual disability (ID) has progressed, they have become similarly at risk of cancer as individuals of the general population. Epidemiological studies indicate a reduced incidence and mortality from lung cancer in the total population of persons with ID. However, the pattern is heterogeneous and the risk is strongly correlated with the impairment level; persons with mild intellectual impairment have higher cancer risk, and this subgroup also has the highest tobacco consumption (the major risk factor for lung cancer) compared to individuals with more severe impairment...
2016: Lung Cancer International
https://www.readbyqxmd.com/read/27746912/sampling-migrants-from-their-social-networks-the-demography-and-social-organization-of-chinese-migrants-in-dar-es-salaam-tanzania
#18
M Giovanna Merli, Ashton Verdery, Ted Mouw, Jing Li
The streams of Chinese migration to Africa are growing in tandem with rising Chinese investments and trade flows in and to the African continent. In spite of the high profile of this phenomenon in the media, there are few rich and broad descriptions of Chinese communities in Africa. Reasons for this include the rarity of official statistics on foreign-born populations in African censuses, the absence of predefined sampling frames required to draw representative samples with conventional survey methods and difficulties to reach certain segments of this population...
July 2016: Migration Studies
https://www.readbyqxmd.com/read/27746850/predictive-modeling-of-cholera-outbreaks-in-bangladesh
#19
Amanda A Koepke, Ira M Longini, M Elizabeth Halloran, Jon Wakefield, Vladimir N Minin
Despite seasonal cholera outbreaks in Bangladesh, little is known about the relationship between environmental conditions and cholera cases. We seek to develop a predictive model for cholera outbreaks in Bangladesh based on environmental predictors. To do this, we estimate the contribution of environmental variables, such as water depth and water temperature, to cholera outbreaks in the context of a disease transmission model. We implement a method which simultaneously accounts for disease dynamics and environmental variables in a Susceptible-Infected-Recovered-Susceptible (SIRS) model...
June 2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/27745705/addressing-the-hidden-mortality-in-cdh-a-population-based-study
#20
Carmen Mesas Burgos, Björn Frenckner
BACKGROUND: Improvements in the clinical management of CDH have led to overall improved reported result from single institutions. However, population-based studies have highlighted a hidden mortality. AIM: To explore the incidence in Sweden and to address the hidden mortality for CDH during a 27-year period in a population-based setting. MATERIALS AND METHODS: This is a population based cohort study that includes all patients diagnosed with CDH that were registered in the National Patient Register, the Medical Birth Register, the Register of Congenital Malformations and the Register for Causes of Death between 1987 and 2013...
September 23, 2016: Journal of Pediatric Surgery
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