keyword
MENU ▼
Read by QxMD icon Read
search

Hidden populations

keyword
https://www.readbyqxmd.com/read/28346895/wheat-genomics-comes-of-age
#1
REVIEW
Cristobal Uauy
Advances in wheat genomics have lagged behind other major cereals (e.g., rice and maize) due to its highly repetitive and large polyploid genome. Recent technological developments in sequencing and assembly methods, however, have largely overcome these barriers. The community now moves to an era centred on functional characterisation of the genome. This includes understanding sequence and structural variation as well as how information is integrated across multiple homoeologous genomes. This understanding promises to uncover variation previously hidden from natural and human selection due to the often observed functional redundancy between homoeologs...
March 24, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28344699/curricular-initiatives-that-enhance-student-knowledge-and-perceptions-of-sexual-and-gender-minority-groups-a-critical-interpretive-synthesis
#2
REVIEW
Jennifer Desrosiers, Tim Wilkinson, Gillian Abel, Suzanne Pitama
BACKGROUND: There is no accepted best practice for optimizing tertiary student knowledge, perceptions, and skills to care for sexual and gender diverse groups. The objective of this research was to synthesize the relevant literature regarding effective curricular initiatives designed to enhance tertiary level student knowledge, perceptions, and skills to care for sexual and gender diverse populations. METHODS: A modified Critical Interpretive Synthesis using a systematic search strategy was conducted in 2015...
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28333587/variational-latent-gaussian-process-for-recovering-single-trial-dynamics-from-population-spike-trains
#3
Yuan Zhao, Il Memming Park
When governed by underlying low-dimensional dynamics, the interdependence of simultaneously recorded populations of neurons can be explained by a small number of shared factors, or a low-dimensional trajectory. Recovering these latent trajectories, particularly from single-trial population recordings, may help us understand the dynamics that drive neural computation. However, due to the biophysical constraints and noise in the spike trains, inferring trajectories from data is a challenging statistical problem in general...
March 23, 2017: Neural Computation
https://www.readbyqxmd.com/read/28318800/autoimmune-disease-development-based-on-possible-mislocalization-of-intracellular-and-extracellular-proteins
#4
Borros Arneth
BACKGROUND: T helper cells can differentiate into several subsets of T lymphocytes, including Th1, Th2, and regulatory T (Treg) cells. As a result of this ability to differentiate, the corresponding T cell receptor (TCR) spectra display considerable cellular plasticity and interchangeability. In contrast, T lymphocyte differentiation and separation into CD4(+) and/or CD8(+) T cell lines creates stable populations over a person's lifetime, which abrogates the plasticity and interchange between these cell types and their corresponding TCR spectra but results in considerable stability regarding the corresponding TCR sequences and spectra...
February 27, 2017: Immunobiology
https://www.readbyqxmd.com/read/28317207/hidden-high-rate-of-preeclampsia-in-twin-compared-to-singleton-pregnancies
#5
Carla Francisco, David Wright, Zsófia Benkő, Argyro Syngelaki, Kypros H Nicolaides
OBJECTIVE: To examine the gestational age at delivery with and without preeclampsia (PE) in dichorionic (DC) and monochorionic (MC) twin pregnancies and determine the relative risk for total and preterm-PE compared to singleton pregnancies. METHODS: This was a screening study for PE in twin pregnancies undergoing first-trimester combined screening for aneuploidy and subsequently delivering two phenotypically normal live or stillborn babies at ≥24 weeks' gestation...
March 19, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28298214/climat-het-detecting-subclonal-copy-number-alterations-and-loss-of-heterozygosity-in-heterogeneous-tumor-samples-from-whole-genome-sequencing-data
#6
Zhenhua Yu, Ao Li, Minghui Wang
BACKGROUND: Copy number alterations (CNA) and loss of heterozygosity (LOH) represent a large proportion of genetic structural variations of cancer genomes. These aberrations are continuously accumulated during the procedure of clonal evolution and patterned by phylogenetic branching. This invariably results in the emergence of multiple cell populations with distinct complement of mutational landscapes in tumor sample. With the advent of next-generation sequencing technology, inference of subclonal populations has become one of the focused interests in cancer-associated studies, and is usually based on the assessment of combinations of somatic single-nucleotide variations (SNV), CNA and LOH...
March 15, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28294109/goal-recognition-based-adaptive-brain-computer-interface-for-navigating-immersive-robotic-systems
#7
Mohammad Abu-Alqumsan, Felix Ebert, Angelika Peer
OBJECTIVE: This work proposes principled strategies for self-adaptations in EEG-based Brain-computer interfaces (BCIs) as a way out of the bandwidth bottleneck resulting from the considerable mismatch between the low-bandwidth interface and the bandwidth-hungry application, and a way to enable fluent and intuitive interaction in embodiment systems. The main focus is laid upon inferring the hidden target goals of users while navigating in a remote environment as a basis for possible adaptations...
March 15, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28284261/tuberculosis-drug-resistance-in-southern-mozambique-results-of-a-population-level-survey-in-the-district-of-manhi%C3%A3-a
#8
S Valencia, D Respeito, S Blanco, R M Ribeiro, E López-Varela, V G Sequera, B Saavedra, E Mambuque, M Gómez Morillo, H Bulo, F Cobelens, E Macete, P L Alonso, J A Caminero, A L García-Basteiro
SETTING: Mozambique, one of the world's high tuberculosis (TB) burden countries, has conducted only one national-level drug resistance survey, in 2007-2008. OBJECTIVE: To determine the drug resistance patterns of laboratory-confirmed TB cases. DESIGN: This was a population-level survey conducted over a 1-year period in the district of Manhiça. All laboratory-confirmed cases were evaluated for first-line anti-tuberculosis drug susceptibility testing using liquid culture...
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28278154/harnessing-the-hidden-genetic-diversity-for-improving-multiple-abiotic-stress-tolerance-in-rice-oryza-sativa-l
#9
Jauhar Ali, Jian-Long Xu, Yong-Ming Gao, Xiu-Fang Ma, Li-Jun Meng, Ying Wang, Yun-Long Pang, Yong-Sheng Guan, Mei-Rong Xu, Jastin E Revilleza, Neil J Franje, Shao-Chuan Zhou, Zhi-Kang Li
To develop superior rice varieties with improved yield in most rainfed areas of Asia/Africa, we started an introgression-breeding program for simultaneously improving yield and tolerances of multiple abiotic stresses. Using eight BC1 populations derived from a widely adaptable recipient and eight donors plus three rounds of phenotypic selection, we developed 496 introgression lines (ILs) with significantly higher yield under drought, salt and/or non-stress conditions in 5 years. Six new varieties were released in the Philippines and Pakistan and many more are being evaluated in multi-location yield trials for releasing in several countries...
2017: PloS One
https://www.readbyqxmd.com/read/28276873/the-hidden-niemann-pick-type-c-patient-clinical-niches-for-a-rare-inherited-metabolic-disease
#10
Christian J Hendriksz, Mathieu Anheim, Peter Bauer, Olivier Bonnot, Anupam Chakrapani, Jean-Christophe Corvol, Tom J de Koning, Anna Degtyareva, Carlo Dionisi-Vici, Sarah Doss, Thomas Duning, Paola Giunti, Rosa Iodice, Tracy Johnston, Dierdre Kelly, Hans-Hermann Klünemann, Stefan Lorenzl, Alessandro Padovani, Miguel Pocovi, Matthis Synofzik, Alta Terblanche, Florian Then Bergh, Meral Topçu, Christine Tranchant, Mark Walterfang, Christian Velten, Stefan A Kolb
BACKGROUND: Niemann-Pick disease type C (NP-C) is a rare, inherited neurodegenerative disease of impaired intracellular lipid trafficking. Clinical symptoms are highly heterogeneous, including neurological, visceral, or psychiatric manifestations. The incidence of NP-C is under-estimated due to under-recognition or misdiagnosis across a wide range of medical fields. New screening and diagnostic methods provide an opportunity to improve detection of unrecognized cases in clinical sub-populations associated with a higher risk of NP-C...
March 2, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28273768/genetic-susceptibility-to-multiple-sclerosis-brain-structure-and-cognitive-function-in-the-general-population
#11
Mohammad Arfan Ikram, Meike W Vernooij, Gennady V Roshchupkin, Albert Hofman, Cornelia M van Duijn, André G Uitterlinden, Wiro J Niessen, Rogier Q Hintzen, Hieab Hh Adams
BACKGROUND: Multiple sclerosis (MS) affects brain structure and cognitive function and has a heritable component. Over a 100 common genetic risk variants have been identified, but most carriers do not develop MS. For other neurodegenerative diseases, risk variants have effects outside patient populations, but this remains uninvestigated for MS. OBJECTIVES: To study the effect of MS-associated genetic variants on brain structure and cognitive function in the general population...
December 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28272531/non-invasive-prenatal-diagnosis-of-beta-thalassemia-by-semiconductor-sequencing-a-feasibility-study-in-the-sardinian-population
#12
Luisella Saba, Maddalena Masala, Valentina Capponi, Giuseppe Marceddu, Matteo Massidda, Maria Cristina Rosatelli
β-Thalassemia is the most common autosomal recessive single-gene disorder in Sardinia, where approximately 10.3% of the population is a carrier. Prenatal diagnosis is carried out at 12 weeks of gestation via villocentesis and is commonly aimed at ascertaining the presence or absence of the HBB variant c.118C>T, which is the most common in Sardinia. In this study, we describe for the first time the application of semiconductor sequencing to the non-invasive prenatal diagnosis of β-thalassemia in 37 couples at risk for this variant...
March 8, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28254940/hidden-dynamics-in-the-unfolding-of-individual-bacteriorhodopsin-proteins
#13
Hao Yu, Matthew G W Siewny, Devin T Edwards, Aric W Sanders, Thomas T Perkins
Protein folding occurs as a set of transitions between structural states within an energy landscape. An oversimplified view of the folding process emerges when transiently populated states are undetected because of limited instrumental resolution. Using force spectroscopy optimized for 1-microsecond resolution, we reexamined the unfolding of individual bacteriorhodopsin molecules in native lipid bilayers. The experimental data reveal the unfolding pathway in unprecedented detail. Numerous newly detected intermediates-many separated by as few as two or three amino acids-exhibited complex dynamics, including frequent refolding and state occupancies of <10 μs...
March 3, 2017: Science
https://www.readbyqxmd.com/read/28253858/a-hybrid-method-for-the-imputation-of-genomic-data-in-livestock-populations
#14
Roberto Antolín, Carl Nettelblad, Gregor Gorjanc, Daniel Money, John M Hickey
BACKGROUND: This paper describes a combined heuristic and hidden Markov model (HMM) method to accurately impute missing genotypes in livestock datasets. Genomic selection in breeding programs requires high-density genotyping of many individuals, making algorithms that economically generate this information crucial. There are two common classes of imputation methods, heuristic methods and probabilistic methods, the latter being largely based on hidden Markov models. Heuristic methods are robust, but fail to impute markers in regions where the thresholds of heuristic rules are not met, or the pedigree is inconsistent...
March 3, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28253851/a-systematic-review-of-studies-with-a-representative-sample-of-refugees-and-asylum-seekers-living-in-the-community-for-participation-in-mental-health-research
#15
Joanne C Enticott, Frances Shawyer, Shiva Vasi, Kimberly Buck, I-Hao Cheng, Grant Russell, Ritsuko Kakuma, Harry Minas, Graham Meadows
BACKGROUND: The aim was to review the literature to identify the most effective methods for creating a representative sample of refugee and asylum seeker groups living in the community to participate in health and mental health survey research. METHODS: A systematic search of academic and grey literature was conducted for relevant literature with 'hidden' groups published between January 1995 and January 2016. The main search used Medline, PsycINFO, EMBASE, CINAHL and SCOPUS electronic databases...
March 2, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28253441/availability-production-and-consumption-of-crops-biofortified-by-plant-breeding-current-evidence-and-future-potential
#16
Amy Saltzman, Ekin Birol, Adewale Oparinde, Meike S Andersson, Dorene Asare-Marfo, Michael T Diressie, Carolina Gonzalez, Keith Lividini, Mourad Moursi, Manfred Zeller
Biofortification is the process of increasing the density of vitamins and minerals in a crop through plant breeding-using either conventional methods or genetic engineering-or through agronomic practices. Over the past 15 years, conventional breeding efforts have resulted in the development of varieties of several staple food crops with significant levels of the three micronutrients most limiting in diets: zinc, iron, and vitamin A. More than 15 million people in developing countries now grow and consume biofortified crops...
February 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28245514/economic-abuse-between-intimate-partners-in-australia-prevalence-health-status-disability-and-financial-stress
#17
Jozica Kutin, Roslyn Russell, Mike Reid
OBJECTIVE: Economic abuse is a form of domestic violence that has a significant impact on the health and financial wellbeing of victims, but is understudied. This study determined the lifetime prevalence of economic abuse in Australia by age and gender, and the associated risk factors. METHODS: The 2012 ABS Personal Safety Survey was used, involving a cross-sectional population survey of 17,050 randomly selected adults using face-to-face interviews. The survey-weighted prevalence of economic abuse was calculated and analysed by age and gender...
February 28, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28224497/hidden-markov-models-in-population-genomics
#18
Julien Y Dutheil
With the advent of sequencing techniques population genomics took a major shift. The structure of data sets has evolved from a sample of a few loci in the genome, sequenced in dozens of individuals, to collections of complete genomes, virtually comprising all available loci. Initially sequenced in a few individuals, such genomic data sets are now reaching and even exceeding the size of traditional data sets in the number of haplotypes sequenced. Because all loci in a genome are not independent, this evolution of data sets is mirrored by a methodological change...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28209289/depression-among-current-former-and-never-smokers-from-2005-to-2013-the-hidden-role-of-disparities-in-depression-in-the-ongoing-tobacco-epidemic
#19
Renee D Goodwin, Melanie M Wall, Lorra Garey, Michael J Zvolensky, Lisa Dierker, Sandro Galea, Misato Gbedemah, Andrea H Weinberger, Jill M Williams, Mei-Chen Hu, Deborah S Hasin
BACKGROUND: After declining sharply for many years, the prevalence of smoking has remained fairly stable over the past decade. One possible explanation is that there has been an increase in the prevalence of barriers to cessation, like depression, among remaining smokers. OBJECTIVES: To estimate changes in the prevalence of depression among current, former and never smokers in the United States (U.S.) population from 2005 to 2013 overall and by age, gender, and income...
April 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28202089/suicidal-ideation-and-behaviour-among-community-and-health-care-seeking-populations-in-five-low-and-middle-income-countries-a-cross-sectional-study
#20
M Jordans, S Rathod, A Fekadu, G Medhin, F Kigozi, B Kohrt, N Luitel, I Petersen, R Shidhaye, J Ssebunnya, V Patel, C Lund
Aims Suicidal behaviour is an under-reported and hidden cause of death in most low- and middle-income countries (LMIC) due to lack of national systematic reporting for cause-specific mortality, high levels of stigma and religious or cultural sanctions. The lack of information on non-fatal suicidal behaviour (ideation, plans and attempts) in LMIC is a major barrier to design and implementation of prevention strategies. This study aims to determine the prevalence of non-fatal suicidal behaviour within community- and health facility-based populations in LMIC...
February 16, 2017: Epidemiology and Psychiatric Sciences
keyword
keyword
87123
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"