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JOURNAL ARTICLE
Salvatore Nigro, Marco Filardi, Benedetta Tafuri, Martina Nicolardi, Roberto De Blasi, Alessia Giugno, Valentina Gnoni, Giammarco Milella, Daniele Urso, Stefano Zoccolella, Giancarlo Logroscino
"Just Accepted" papers have undergone full peer review and have been accepted for publication in Radiology: Artificial Intelligence . This article will undergo copyediting, layout, and proof review before it is published in its final version. Please note that during production of the final copyedited article, errors may be discovered which could affect the content. Purpose To develop a fast and fully automated deep learning (DL)-based method for the MRI planimetric segmentation and measurement of the brainstem and ventricular structures most affected in patients with progressive supranuclear palsy (PSP)...
March 20, 2024: Radiology. Artificial intelligence
#22
JOURNAL ARTICLE
Maria Ciccarelli, Barbara Pizzini, Mark D Griffiths, Marina Cosenza, Giovanna Nigro, Francesca D'Olimpio
INTRODUCTION: Empirical studies have demonstrated the role that attentional bias, the mutual excitatory relationship between attentional bias and craving, and mentalizing play in problem gambling. Although problem gambling rates among older-aged adults have steadily increased in recent years, research studies among this cohort are scarce. The present study is the first to empirically investigate attentional bias, as well as the joint role of attentional bias, craving, and mentalizing among older-aged gamblers...
March 19, 2024: BMC Psychology
#23
JOURNAL ARTICLE
Carlo Chessari, Edoardo Simonetta, Francesco Amati, Mattia Nigro, Anna Stainer, Giovanni Sotgiu, Mariangela Puci, Andrea Gramegna, Francesco Blasi, Letizia Corinna Morlacchi, Agata Alba Maria Domenica Buscemi, Valentina Conio, Vincenzo Sanci, Angelo G Corsico, Paola Faverio, Weronika Michalak, Fabrizio Luppi, Claudia Crimi, Carlo Vancheri, Raffaele Campisi, Maria Rosaria Vulpi, Giovanna Elisiana Carpagnano, Marianna Cicchetti, Kseniia Sekretna, Nicola Scichilone, Salvatore Battaglia, Stefano Aliberti
It takes ∼3.5 years to reach a diagnosis of bronchiectasis from onset of symptoms: the long patient's journey in Italy https://bit.ly/46XMWAz.
March 2024: ERJ Open Research
#24
JOURNAL ARTICLE
Nicola Tambasco, Alessandro Mechelli, Pasquale Nigro, Simone Simoni, Federico Paolini Paoletti, Paolo Eusebi, Elona Brahimi, Carlo Maremmani, Lucilla Parnetti
BACKGROUND: Olfactory dysfunction is a non-motor symptom and an important biomarker of Parkinson's disease (PD) because of its high prevalence (> 90%). Whether hyposmia correlates with motor symptoms is unclear. In the present study, we aim to investigate the relationship between olfactory impairment with both motor and non-motor features and disease variables (disease duration, stage, and severity). METHODS: One-hundred fifty-four PD patients were evaluated...
March 19, 2024: Neurological Sciences
#25
JOURNAL ARTICLE
Eleonora Turrini, Luca Ulfo, Paolo Emidio Costantini, Roberto Saporetti, Matteo Di Giosia, Michela Nigro, Annapaola Petrosino, Lucia Pappagallo, Alena Kaltenbrunner, Andrea Cantelli, Valentina Pellicioni, Elena Catanzaro, Carmela Fimognari, Matteo Calvaresi, Alberto Danielli
Photodynamic therapy (PDT) represents an emerging strategy to treat various malignancies, including colorectal cancer (CC), the third most common cancer type. This work presents an engineered M13 phage retargeted towards CC cells through pentavalent display of a disulfide-constrained peptide nonamer. The M13CC nanovector was conjugated with the photosensitizer Rose Bengal (RB), and the photodynamic anticancer effects of the resulting M13CC -RB bioconjugate were investigated on CC cells. We show that upon irradiation M13CC -RB is able to impair CC cell viability, and that this effect depends on i) photosensitizer concentration and ii) targeting efficiency towards CC cell lines, proving the specificity of the vector compared to unmodified M13 phage...
March 17, 2024: Cellular and Molecular Life Sciences: CMLS
#26
JOURNAL ARTICLE
Mauro Biffi, Eduardo Celentano, Massimo Giammaria, Antonio Curnis, Giovanni Rovaris, Matteo Ziacchi, Gennaro Miracapillo, Davide Saporito, Matteo Baroni, Fabio Quartieri, Massimiliano Marini, Patrizia Pepi, Gaetano Senatore, Fabrizio Caravati, Valeria Calvi, Luca Tomasi, Gerardo Nigro, Luca Bontempi, Francesca Notarangelo, Vincenzo Ezio Santobuono, Giulio Boggian, Giuseppe Arena, Francesco Solimene, Marzia Giaccardi, Giampiero Maglia, Alessandro Paoletti Perini, Mario Volpicelli, Daniele Giacopelli, Alessio Gargaro, Saverio Iacopino
BACKGROUND: Atrial high-rate episodes (AHRE) are frequent in patients with cardiac implantable electronic devices. A decrease in device-detected P-wave amplitude may be an indicator of periods of increased risk of AHRE. OBJECTIVE: To assess the association between P-wave amplitude and AHRE incidence. METHODS: Remote monitoring data from 2,579 patients with no history of atrial fibrillation (23% pacemakers, 77% implantable cardioverter-defibrillators [ICDs] of which 40% providing cardiac resynchronization therapy [CRT]) were used to calculate the mean P-wave amplitude during 1 month after implantation...
March 15, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#27
JOURNAL ARTICLE
Leandro Stocco Baccarin, Thiago Leite Beaini, Luiz Eugênio Nigro Mazzilli, Rodolfo Francisco Haltenhoff Melani
As an auxiliary method in the process of human identification, forensic facial approximation (FFA) is an important tool for identifying unknown human bodies whose remains do not present the necessary traceability to any antemortem data collection. Specific characteristics are necessary when addressing children aged between 6 and 10 years, who have little sexual differentiation and a mixed dentition. Due to the chronology of eruption of the permanent second molars in this population, it is not possible to measure facial soft-tissue thickness (FSTT) from specific landmarks such as supra and infra M2...
March 2, 2024: Legal Medicine
#28
JOURNAL ARTICLE
Gabriele Bongiovanni, Antonio Tonutti, Anna Stainer, Mattia Nigro, Dean L Kellogg, Anoop Nambiar, Andrea Gramegna, Marco Mantero, Antonio Voza, Francesco Blasi, Stefano Aliberti, Francesco Amati
OBJECTIVES: Vasoactive drugs have exhibited clinical efficacy in addressing pulmonary arterial hypertension, manifesting a significant reduction in morbidity and mortality. Pulmonary hypertension may complicate advanced interstitial lung disease (PH-ILD) and is associated with high rates of disability, hospitalisation due to cardiac and respiratory illnesses, and mortality. Prior management hinged on treating the underlying lung disease and comorbidities. However, the INCREASE trial of inhaled treprostinil in PH-ILD has demonstrated that PH-ILD can be effectively treated with vasoactive drugs...
March 13, 2024: BMJ Open Respiratory Research
#29
Levosimendan predicts response to cardiac contractility modulation therapy: a pilot study. Response.
Daniele Masarone, Luigi Falco, Antonio D'onofrio, Gerardo Nigro, Ernesto Ammendola, Giuseppe Pacileo
No abstract text is available yet for this article.
March 7, 2024: Revista Española de Cardiología
#30
JOURNAL ARTICLE
Arcangelo Prete, Edoardo Lanino, Francesco Saglio, Alessandra Biffi, Elisabetta Calore, Maura Faraci, Roberto Rondelli, Claudio Favre, Marco Zecca, Gabriella Casazza, Fulvio Porta, Roberto Luksch, Simone Cesaro, Marco Rabusin, Rosanna Parasole, Rosa Maria Mura, Luca Lo Nigro, Davide Leardini, Daria Pagliara, Franco Locatelli, Franca Fagioli
Despite aggressive multimodal treatment, the outcome of pediatric patients affected by high-risk (HR) neuroblastoma (NB) remains poor. The rational of use of allogeneic hematopoietic stem cell transplantation (allo-HCT) for NB was based on the possible graft versus tumor effect; however, toxicity represents a limitation to its efficacy. We sought to prospectively assess the feasibility and efficacy of allo-HCT using a reduced intensity conditioning regimen in pediatric patients with HR NB in a multicenter phase II trial...
March 7, 2024: Transplantation and cellular therapy
#31
JOURNAL ARTICLE
Consuelo Venturi, Antonio Guadagno, Serena Varesano, Valentina Ricucci, Nicola Nigro, Antonio Di Biagio, Matteo Bassetti, Paolo Nozza, Francesco Drago, Aurora Parodi, Giulia Ciccarese
BACKGROUND: a few pathologic and ultrastructural findings of monkeypox skin lesions are available in the literature. To integrate such evidence, we aimed to describe the pathologic features of monkeypox skin lesions and to show monkeypox virions by transmission electron microscopy (TEM). METHODS: we studied the cutaneous biopsies of three patients affected by monkeypox during the 2022 monkeypox outbreak. Skin biopsies have been collected only from body sites with a recent laboratory-confirmed mpox virus infection, defined by a polymerase chain reaction (PCR) positive result in specimens taken through skin swabs...
2024: Le Infezioni in Medicina
#32
JOURNAL ARTICLE
Vincent Planche, Boris Mansencal, Jose V Manjon, Wassilios G Meissner, Thomas Tourdias, Pierrick Coupé
Brain charts for the human lifespan have been recently proposed to build dynamic models of brain anatomy in normal aging and various neurological conditions. They offer new possibilities to quantify neuroanatomical changes from preclinical stages to death, where longitudinal MRI data are not available. In this study, we used brain charts to model the progression of brain atrophy in progressive supranuclear palsy-Richardson syndrome. We combined multiple datasets ( n = 8170 quality controlled MRI of healthy subjects from 22 cohorts covering the entire lifespan, and n = 62 MRI of progressive supranuclear palsy-Richardson syndrome patients from the Four Repeat Tauopathy Neuroimaging Initiative (4RTNI)) to extrapolate lifetime volumetric models of healthy and progressive supranuclear palsy-Richardson syndrome brain structures...
2024: Brain communications
#33
JOURNAL ARTICLE
Carlo Dani, Marcello Napolitano, Ciro Barone, Angelo Manna, Gabriella Nigro, Gianfranco Scarpelli, Elvira Bonanno, Sara Gatto, Francesco Cavigioli, Carlo Forcellini, Enrico Petoello, Renzo Beghini, Martina Ciarcià, Monica Fusco, Fabio Mosca, Anna Lavizzari, Eloisa Gitto, Letteria Barbuscia, Pasqua Betta, Carmine Mattia, Luigi Corvaglia, Stefania Vedovato, Giovanni Vento, Gianfranco Maffei, Raffaele Falsaperla, Paola Lago, Luca Boni, Gianluca Lista
INTRODUCTION: Approximately half of very preterm infants with respiratory distress syndrome (RDS) fail treatment with nasal continuous positive airway pressure (NCPAP) and need mechanical ventilation (MV). OBJECTIVES: Our aim with this study was to evaluate if nasal intermittent positive pressure ventilation (NIPPV) during less invasive surfactant treatment (LISA) can improve respiratory outcome compared with NCPAP. MATERIALS AND METHODS: We carried out an open-label randomized controlled trial at tertiary neonatal intensive care units in which infants with RDS born at 25+0 -31+6 weeks of gestation between December 1, 2020 and October 31, 2022 were supported with NCPAP before and after surfactant administration and received NIPPV or NCPAP during LISA...
January 22, 2024: Pediatric Pulmonology
#34
JOURNAL ARTICLE
Jil D Stegmann, Jeshurun C Kalanithy, Gabriel C Dworschak, Nina Ishorst, Enrico Mingardo, Filipa M Lopes, Yee Mang Ho, Phillip Grote, Tobias T Lindenberg, Öznur Yilmaz, Khadija Channab, Steve Seltzsam, Shirlee Shril, Friedhelm Hildebrandt, Felix Boschann, André Heinen, Angad Jolly, Katherine Myers, Kim McBride, Mir Reza Bekheirnia, Nasim Bekheirnia, Marcello Scala, Manuela Morleo, Vincenzo Nigro, Annalaura Torella, Michele Pinelli, Valeria Capra, Andrea Accogli, Silvia Maitz, Alice Spano, Rory J Olson, Eric W Klee, Brendan C Lanpher, Se Song Jang, Jong-Hee Chae, Philipp Steinbauer, Dietmar Rieder, Andreas R Janecke, Julia Vodopiutz, Ida Vogel, Jenny Blechingberg, Jennifer L Cohen, Kacie Riley, Victoria Klee, Laurence E Walsh, Matthias Begemann, Miriam Elbracht, Thomas Eggermann, Arzu Stoppe, Kyra Stuurman, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Maureen S Mulhern, Tristan T Sands, Cheryl Cytrynbaum, Rosanna Weksberg, Federica Isidori, Tommaso Pippucci, Giulia Severi, Francesca Montanari, Michael C Kruer, Somayeh Bakhtiari, Hossein Darvish, Heiko Reutter, Gregor Hagelueken, Matthias Geyer, Adrian S Woolf, Jennifer E Posey, James R Lupski, Benjamin Odermatt, Alina C Hilger
CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals from eleven independent families with bi-allelic variants in CELSR3. Affected individuals presented with an overlapping phenotypic spectrum comprising central nervous system (CNS) anomalies (7/12), combined CNS anomalies and congenital anomalies of the kidneys and urinary tract (CAKUT) (3/12) and CAKUT only (2/12). Computational simulation of the 3D protein structure suggests the position of the identified variants to be implicated in penetrance and phenotype expression...
March 1, 2024: NPJ Genomic Medicine
#35
JOURNAL ARTICLE
Pietro Palmisano, Gabriele Dell'Era, Federico Guerra, Ernesto Ammendola, Matteo Ziacchi, Mattia Laffi, Paolo Donateo, Alessandro Guido, Chiara Ghiglieno, Antonio Parlavecchio, Antonio Dello Russo, Gerardo Nigro, Mauro Biffi, Germano Gaggioli, Jacopo Senes, Giuseppe Patti, Michele Accogli, Giovanni Coluccia
BACKGROUND: Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is a well-established therapy in patients with reduced left ventricular ejection fraction (LVEF), heart failure, and left bundle branch (LBB) block. LBB area pacing (LBBAP) has recently been shown to be a feasible and effective alternative to BVP. Comparative data on the risk of complications between LBBAP and BVP among patients undergoing CRT are lacking. OBJECTIVE: The aim of this study was to compare the long-term risk of procedure-related complications between LBBAP and BVP in a cohort of patients undergoing CRT...
February 28, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#36
Gianmarco Borriello, Michelangelo Nigro, Pierluigi D'Angiò, Simona Laurino, Andrea Gigliotti, Davide Viggiano, Giuseppe Gigliotti
Renal involvement is very common in patients with HIV infection. The phenotype varies from the most frequently "collapsing" variant of focal and segmental glomerulosclerosis (FSGS) to "lupus-like HIV-immune complex kidney disease" (HIVICK). The latter is characterized by a histological picture that recalls lupus nephropathy. Through a clinical case, we underline the importance of urinary sediment analysis in patients with suspected glomerulopathy. Findings such as the characteristic cells that show the typical appearance of Herpes virus (HSV) infection or LE cells have significantly supported the diagnosis of HIVICK...
February 28, 2024: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
#37
JOURNAL ARTICLE
Selina M Yogeshwar, Sergio Muñiz-Castrillo, Lidia Sabater, Vicente Peris-Sempere, Vamsee Mallajosyula, Guo Luo, Han Yan, Eric Yu, Jing Zhang, Ling Lin, Flavia Fagundes Bueno, Xuhuai Ji, Géraldine Picard, Véronique Rogemond, Anne Laurie Pinto, Anna Heidbreder, Romana Höftberger, Francesc Graus, Josep Dalmau, Joan Santamaria, Alex Iranzo, Bettina Schreiner, Maria Pia Giannoccaro, Rocco Liguori, Takayoshi Shimohata, Akio Kimura, Yoya Ono, Sophie Binks, Sara Mariotto, Alessandro Dinoto, Michael Bonello, Christian J Hartmann, Nicola Tambasco, Pasquale Nigro, Harald Prüss, Andrew McKeon, Mark M Davis, Sarosh R Irani, Jérôme Honnorat, Carles Gaig, Carsten Finke, Emmanuel Mignot
Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. The disease displays a heterogeneous phenotype that includes sleep, movement, and bulbar-associated dysfunction. Presence of IgLON5-antibodies in CSF/serum, together with a strong association with HLA-DRB1*10:01∼DQB1*05:01, support an autoimmune basis. In this study, a multicentric HLA study of 87 anti-IgLON5 patients revealed a stronger association with HLA-DQ than HLA-DR. Specifically, we identified a predisposing rank-wise association with HLA-DQA1*01:05∼DQB1*05:01, HLA-DQA1*01:01∼DQB1*05:01 and HLA-DQA1*01:04∼DQB1*05:03 in 85% of patients...
March 1, 2024: Brain
#38
JOURNAL ARTICLE
Vincenzo Russo, Angelo Comune, Erika Parente, Anna Rago, Andrea Antonio Papa, Gerardo Nigro, Michele Brignole
BACKGROUND: Approximately 50% of patients with unexplained syncope and negative head-up tilt test (HUTT) who have an electrocardiogram (ECG) documentation of spontaneous syncope during implantable loop recorder (ILR) show an asystolic pause at the time of the event. OBJECTIVE: The aim of the study was to evaluate the age distribution and clinical predictors of asystolic syncope detected by ILR in patients with unexplained syncope and negative HUTT. METHODS: This research employed a retrospective, single-center study of consecutive patients...
February 25, 2024: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
#39
JOURNAL ARTICLE
Alessandra Di Paola, Maria Maddalena Marrapodi, Elvira Pota, Rosa Colucci Cante, Deeksha Rana, Giulia Giliberti, Giuseppe Di Feo, Shakeel Ahmed, Domenico Roberti, Roberto Nigro, Francesca Rossi, Maura Argenziano
The advancement of anti-cancer therapies has markedly improved the survival rate of children with cancer, making them long-term childhood cancer survivors (CCS). Nevertheless, these treatments cause a low-grade inflammatory state, determining inflamm-aging and, thus, favoring the early onset of chronic diseases normally associated with old age. Identification of novel and safer therapeutic strategies is needed to counteract and prevent inflamm-aging. Macrophages are cells involved in immune and inflammatory responses, with a pivotal role in iron metabolism, which is related to inflammation...
February 8, 2024: Cancers
#40
REVIEW
Angelo Maria Velardi, Pietro Anoldo, Stefania Nigro, Giuseppe Navarra
This article examines the evolution of bariatric surgery, with a focus on emerging technologies such as robotics and laparoscopy. In the case of gastric bypass, no significant differences have emerged between the two techniques in terms of hospitalization duration, weight loss, weight regain, or 30-day mortality. Robotic surgery, while requiring more time in the operating room, has been associated with lower rates of bleeding, mortality, transfusions, and infections. In revisional bariatric surgery, the robotic approach has shown fewer complications, shorter hospital stays, and a reduced need for conversion to open surgery...
January 30, 2024: Journal of Personalized Medicine
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