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https://www.readbyqxmd.com/read/28922211/acute-effects-of-ammonia-inhalants-on-strength-and-power-performance-in-trained-men
#1
Sandro Bartolomei, Federico Nigro, Gubellini Luca, Semprini Gabriele, Simone Ciacci, Jay R Hoffman, Franco Merni
The aim of the present study was to investigate the influence of ammonia inhalants on lower body power and maximal isometric strength in trained men. Twenty experienced resistance trained men (age = 26.7 ± 3.7 y; body weight = 80.59 ± 9.0 kg; body height = 179.5 ± 5.7 cm) were tested for counter movement jump power (CMJP), maximal force and rate of force development (pRFD20) expressed during an isometric mid-thigh pull (IMTP). Assessments were performed using either an ammonia salt inhalants (AI), a placebo (PL) or no inhalants (N)...
September 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28919247/the-effect-of-directed-photic-stimulation-of-the-pineal-on-experimental-parkinson-s-disease
#2
Gregory L Willis, Christopher B Freelance
The role of the circadian system in Parkinson's disease (PD) is a topic of increasing scientific interest. This has emerged from recent studies demonstrating an altered response of PD patients to treatment in relation to the phase of the light/dark cycle and from other work defining the functional significance of melanocytes in PD: a cell type that the nigro-striatal dopamine (NSD) system and circadian system both contain. The present study was undertaken to determine the sensitivity of the pineal, as the final common pathway of the circadian system, to light delivered directly to the pineal via surgical implantation of LEDs...
September 15, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28912019/a-nigro-vagal-pathway-controls-gastric-motility-and-is-affected-in-a-rat-model-of-parkinsonism
#3
Laura Anselmi, Luca Toti, Cecilia Bove, Jessica Hampton, R Alberto Travagli
BACKGROUND & AIMS: In most patients with Parkinson's disease, gastrointestinal (GI) dysfunctions, such as gastroparesis and constipation, are prodromal to the cardinal motor symptoms of the disease. Sporadic Parkinson's disease has been proposed to develop following ingestion of neurotoxicants that affect the brain-gut axis via the vagus nerve, and then travel to higher centers compromising the substantia nigra pars compacta (SNpc), and, later, the cerebral cortex. We aimed to identify the pathway that connects the brainstem vagal nuclei and the SNpc, and to determine whether this pathway is compromised in a rat model of Parkinsonism...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28906030/pathological-and-immunoblot-analysis-of-phosphorylated-tdp-43-in-sporadic-amyotrophic-lateral-sclerosis-with-pallido-nigro-luysian-degeneration
#4
Akiko Uchino, Mieko Ogino, Junko Takahashi-Fujigasaki, Saori Oonuma, Naomi Kanazawa, Sabine Kajita, Masaaki Ichinoe, Masato Hasegawa, Kazutoshi Nishiyama, Shigeo Murayama
Transactivation response DNA-binding protein 43 kDa (TDP-43) is a key protein of sporadic amyotrophic lateral sclerosis (ALS), and phosphorylated form of TDP-43 (p-TDP-43) is a major pathological protein that accumulates in sporadic ALS. p-TDP-43 is found not only in primary motor neurons, but often propagates to non-motor systems as well. However, pallido-nigro-luysian (PNL) degeneration (PNLD) is rarely associated with ALS. We describe here a 68-year-old ALS patient presenting severe PNLD. He had difficulty walking due to poor movement of his right leg, and was diagnosed as having Parkinson's disease because of akinesia...
September 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28902392/expanding-the-clinical-and-molecular-spectrum-of-prmt7-mutations-three-additional-patients-and-review
#5
Emanuele Agolini, Maria Lisa Dentici, Emanuele Bellacchio, Viola Alesi, Francesca Clementina Radio, Annalaura Torella, Francesco Musacchia, Marco Tartaglia, Bruno Dallapiccola, Vincenzo Nigro, Maria Cristina Digilio, Antonio Novelli
Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues. Arginine methylation is involved in multiple biological processes, such as signal transduction, mRNA splicing, transcriptional control, DNA repair, and protein translocation. Currently, seven patients have been described harboring compound heterozygous or homozygous variants in the PRMT7 gene, causing a novel intellectual disability syndrome, known as SBIDDS syndrome (Short Stature, Brachydactyly, Intellectual Developmental Disability, and Seizures)...
September 13, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28878129/correction-of-intermittent-hypoxia-reduces-inflammation-in-obese-subjects-with-obstructive-sleep-apnea
#6
Sebastio Perrini, Angelo Cignarelli, Vitaliano Nicola Quaranta, Vito Antonio Falcone, Stella Kounaki, Stefania Porro, Alessandro Ciavarella, Romina Ficarella, Maria Barbaro, Valentina Annamaria Genchi, Pasquale Nigro, Pierluigi Carratù, Annalisa Natalicchio, Luigi Laviola, Onofrio Resta, Francesco Giorgino
BACKGROUND: In obese subjects with obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) may be linked to systemic and adipose tissue inflammation. METHODS: We obtained abdominal subcutaneous adipose tissue biopsies from OSA and non-OSA obese (BMI > 35) subjects at baseline and after 24 weeks (T1) of weight-loss intervention plus continuous positive airway pressure (c-PAP) or weight-loss intervention alone, respectively. OSA subjects were grouped according to good (therapeutic) or poor (subtherapeutic) adherence to c-PAP...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28860859/head-and-neck-cancer-improving-outcomes-with-a-multidisciplinary-approach
#7
REVIEW
Cristiana Lo Nigro, Nerina Denaro, Anna Merlotti, Marco Merlano
For early-stage head and neck cancer (HNC), surgery (S) or radiotherapy (RT) is a standard treatment. The multidisciplinary approach, which includes multimodality treatment with S followed by RT, with or without chemotherapy (CT) or concurrent chemoradiotherapy (CRT), is required for locally advanced head and neck cancer (LAHNC). CRT improves prognosis, locoregional control (LRC), and organ function in LAHNC, compared to RT alone. Prognosis in recurrent/metastatic HNC (R/M HNC) is dismal. Platinum-based CT, combined with the anti-Epidermal Growth Factor Receptor (EGFR) antibody (Ab) cetuximab, is used in first-line setting, while no further validated options are available at progression...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28841489/the-illusion-of-handy-wins-problem-gambling-chasing-and-affective-decision-making
#8
Giovanna Nigro, Maria Ciccarelli, Marina Cosenza
BACKGROUND: Chasing losses is a behavioral marker and a diagnostic criterion for gambling disorder. It consists in continuing gambling to recoup previous losses. Although chasing has been recognized playing a central role in gambling disorder, research on this topic is relatively scarce, and it remains unclear whether chasing affects decision-making in behavioral tasks in which participants gain or loss some money. Even if several studies found that the more the gambling involvement, the poorer the decision-making, to date no research investigated the role of chasing in decision-making...
August 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28831764/motor-impairment-and-compensation-in-a-hemiparkinsonian-rat-model-correlation-between-dopamine-depletion-severity-cerebral-metabolism-and-gait-patterns
#9
Elena Kordys, Nadine Apetz, Katharina Schneider, Eilidh Duncan, Beatriz Büschbell, Cathrin Rohleder, Michael Sué, Alexander Drzezga, Bernd Neumaier, Lars Timmermann, Heike Endepols
BACKGROUND: In Parkinson's disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment, while hypermetabolism may indicate compensatory activity. In order to associate metabolic patterns with pathophysiological and compensatory mechanisms, we combined resting state [(18)F]FDG-PET (to demonstrate brain metabolism in awake animals), [(18)F]FDOPA-PET (dopamine depletion severity) and gait analysis in a unilateral 6-hydroxydopamine rat model...
August 23, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28831348/animation-deformity-in-postmastectomy-implant-based-reconstruction
#10
Lauren C Nigro, Nadia P Blanchet
Despite increasing interest in prepectoral implant-based reconstruction to avoid animation deformity (AD), the prevalence of this deformity and patient attitudes toward it have not been extensively studied. The purpose of this study was to report on AD in the breast reconstruction population and identify those at highest risk. METHODS: A retrospective chart review was completed for patients at least 6 months postoperative from subpectoral, implant-based breast reconstruction using acellular dermal matrix in the lower pole...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28815207/novel-ampd2-mutation-in-pontocerebellar-hypoplasia-dysmorphisms-and-teeth-abnormalities
#11
Andrea Accogli, Michele Iacomino, Francesca Pinto, Alessandro Orsini, Maria Stella Vari, Raed Selmi, Annalaura Torella, Vincenzo Nigro, Carlo Minetti, Mariasavina Severino, Pasquale Striano, Valeria Capra, Federico Zara
No abstract text is available yet for this article.
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28794981/a-test-retest-study-on-parkinson-s-ppmi-dataset-yields-statistically-significant-white-matter-fascicles
#12
Martin Cousineau, Pierre-Marc Jodoin, Félix C Morency, Verena Rozanski, Marilyn Grand'Maison, Barry J Bedell, Maxime Descoteaux
In this work, we propose a diffusion MRI protocol for mining Parkinson's disease diffusion MRI datasets and recover robust disease-specific biomarkers. Using advanced high angular resolution diffusion imaging (HARDI) crossing fiber modeling and tractography robust to partial volume effects, we automatically dissected 50 white matter (WM) fascicles. These fascicles connect deep nuclei (thalamus, putamen, pallidum) to different cortical functional areas (associative, motor, sensorimotor, limbic), basal forebrain and substantia nigra...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28783090/validation-study-of-italian-version-of-inventory-for-d%C3%A3-j%C3%A3-vu-experiences-assessment-i-idea-a-screening-tool-to-detect-d%C3%A3-j%C3%A3-vu-phenomenon-in-italian-healthy-individuals
#13
Laura Mumoli, Giovanni Tripepi, Umberto Aguglia, Antonio Augimeri, Rossella Baggetta, Francesca Bisulli, Antonella Bruni, Salvatore M Cavalli, Alfredo D'Aniello, Ornella Daniele, Carlo Di Bonaventura, Giancarlo Di Gennaro, Jinane Fattouch, Edoardo Ferlazzo, Alessandra Ferrari, Annateresa Giallonardo, Sara Gasparini, Salvatore Nigro, Andrea Romigi, Vito Sofia, Paolo Tinuper, Maria Grazia Vaccaro, Leila Zummo, Aldo Quattrone, Antonio Gambardella, Angelo Labate
The Inventory Déjà Vu Experiences Assessment (IDEA) is the only screening instrument proposed to evaluate the Déjà vu (DV) experience. Here, we intended to validate the Italian version of IDEA (I-IDEA) and at the same time to investigate the incidence and subjective qualities of the DV phenomenon in healthy Italian adult individuals on basis of an Italian multicentre observational study. In this study, we report normative data on the I-IDEA, collected on a sample of 542 Italian healthy subjects aging between 18-70 years (average age: 40) with a formal educational from 1-19 years...
August 7, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28781201/seven-tesla-mri-of-the-substantia-nigra-in-patients-with-rapid-eye-movement-sleep-behavior-disorder
#14
Daniela Frosini, Mirco Cosottini, Graziella Donatelli, Mauro Costagli, Laura Biagi, Claudio Pacchetti, Michele Terzaghi, Pietro Cortelli, Dario Arnaldi, Enrica Bonanni, Michela Tosetti, Ubaldo Bonuccelli, Roberto Ceravolo
INTRODUCTION: Susceptibility-weighted imaging of the substantia nigra (SN) both at 7 and 3 Tesla (T) has shown high accuracy in distinguishing patients with Parkinson's disease (PD) and healthy subjects (HS). Patients with rapid eye movement (REM) behavior disorder (RBD) can develop synucleinopathies, and such risk is higher with dopamine transporter single photon emission tomography (123I-FP-CIT SPECT) evidence of nigro-striatal dysfunction. We aimed at evaluating SN 7T magnetic resonance imaging (7T-MRI) in patients with RBD and determining the agreement between MRI and 123I-FP-CIT SPECT...
August 2, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28774789/impaired-cbs-h2s-signaling-axis-contributes-to-mptp-induced-neurodegeneration-in-a-mouse-model-of-parkinson-s-disease
#15
Yu-Qing Yuan, Ya-Li Wang, Bao-Shi Yuan, Xin Yuan, Xiao-Ou Hou, Jin-Song Bian, Chun-Feng Liu, Li-Fang Hu
Hydrogen sulfide (H2S), a novel neuromodulator, is linked to the pathogenesis of several neurodegenerative disorders. Exogenous application of H2S exerts neuroprotection via anti-inflammation and anti-oxidative stress in animal and cellular models of Parkinson's disease (PD). However, the role of endogenous H2S and the contribution of its various synthases in PD remain unclear. In the present study, we found a decline of plasma and striatal sulfide level in 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD mouse model...
August 1, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28767677/limited-trophic-partitioning-among-sympatric-delphinids-off-a-tropical-oceanic-atoll
#16
Hillary Young, Katherine Nigro, Douglas J McCauley, Lisa T Ballance, Erin M Oleson, Simone Baumann-Pickering
Understanding trophic relationships among marine predators in remote environments is challenging, but it is critical to understand community structure and dynamics. In this study, we used stable isotope analysis of skin biopsies to compare the isotopic, and thus, trophic niches of three sympatric delphinids in the waters surrounding Palmyra Atoll, in the Central Tropical Pacific: the melon-headed whale (Peponocephala electra), Gray's spinner dolphin (Stenella longirostris longirostris), and the common bottlenose dolphin (Tursiops truncatus)...
2017: PloS One
https://www.readbyqxmd.com/read/28767192/expanding-the-phenotype-of-dst-related-disorder-a-case-report-suggesting-a-genotype-phenotype-correlation
#17
Gerarda Cappuccio, Michele Pinelli, Annalaura Torella, Marianna Alagia, Renata Auricchio, Annamaria Staiano, Vincenzo Nigro, Nicola Brunetti-Pierri
The gene DST encodes for the large protein BPAG1 involved in hemidesmosomes. Its alternative splicing gives rise to tissue-enriched isoforms in brain, muscle, and skin. The few patients described so far with bi-allelic mutations in the DST gene have either a skin phenotype of epidermolysis bullosa simplex or a neurological phenotype. Here, we report a 17-year-old female individual presenting with a more complex phenotype consisting of both skin and neuronal involvement, in addition to several previously unreported findings, such as iris heterochromia, cataract, hearing impairment, syringomyelia, behavioral, and gastrointestinal issues, osteoporosis, and growth hormone deficiency...
August 2, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28762262/embodiment-mediates-the-relationship-between-avoidant-attachment-and-eating-disorder-psychopathology
#18
Alessio Maria Monteleone, Giovanni Castellini, Valdo Ricca, Umberto Volpe, Francesco De Riso, Massimiliano Nigro, Francesco Zamponi, Milena Mancini, Giovanni Stanghellini, Palmiero Monteleone, Janet Treasure, Mario Maj
OBJECTIVE: The overvaluation of body shape and weight of persons with eating disorders (EDs) is putatively explained by a disturbance in the way they experience their own body (embodiment). Moreover, attachment disorders seem to promote the use of body as source for self-definition. Therefore, we assessed the role of embodiment in the connection between attachment styles and ED psychopathology. METHOD: One-hundred and thirteen ED patients and 117 healthy subjects completed the Identity and Eating Disorders (IDEA) Questionnaire, the Eating Disorder Inventory-2 (EDI-2) and the Experiences in Close Relationships Scale...
July 31, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28743955/early-synaptic-dysfunction-induced-by-%C3%AE-synuclein-in-a-rat-model-of-parkinson-s-disease
#19
Jenny-Ann Phan, Kathrine Stokholm, Justyna Zareba-Paslawska, Steen Jakobsen, Kim Vang, Albert Gjedde, Anne M Landau, Marina Romero-Ramos
Evidence suggests that synapses are affected first in Parkinson's disease (PD). Here, we tested the claim that pathological accumulation of α-synuclein, and subsequent synaptic disruption, occur in absence of dopaminergic neuron loss in PD. We determined early synaptic changes in rats that overexpress human α-synuclein by local injection of viral-vectors in midbrain. We aimed to achieve α-synuclein levels sufficient to induce terminal pathology without significant loss of nigral neurons. We tested synaptic disruption in vivo by analyzing motor defects and binding of a positron emission tomography (PET) radioligand to the vesicular monoamine transporter 2, (VMAT2), [(11)C]dihydrotetrabenazine (DTBZ)...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28738670/antidoping-program-an-important-factor-in-the-promotion-and-protection-of-the-integrity-of-sport-and-athlete-s-health
#20
Filomena Mazzeo, Vincenzo Monda, Stefania Santamaria, Ersilia Nigro, Anna Valenzano, Ines Villano, Giuseppe Cibelli, Antonietta Messina, Giovanni Messina
Use of performance-enhancing drugs concern not only elite Olympic and Paralympic Games' athletes but also amateur athletes, who are making increasing use of substances and/or methods. Furthermore, a new frontier reached by the doping is the use of genes. World Anti- Doping Agency (WADA), expressly prohibited the participation in competitive sports by the athlete in case of taking banned substances to treat disease in the event that the above assumption implies an excessive improvement of performance. This study aims to analyze and show the doping control as an essential part of the anti-doping program to promote and protect the integrity of sport and athlete's health...
July 24, 2017: Journal of Sports Medicine and Physical Fitness
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