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Michelangelo Nigro, Davide Viggiano, Vincenzo Ragone, Tiziana Trabace, Annamaria di Palma, Michele Rossini, Giovambattista Capasso, Loreto Gesualdo, Giuseppe Gigliotti
BACKGROUND: The classical approach to the analysis of kidney biopsies is based on semi-quantitative scores of the amount of sclerosis, inflammatory infiltrate, fibrosis and vascular damage. However, advanced renal lesions may be accompanied by a paucity of clinical features and, conversely, important clinical abnormalities may be accompanied by minimal histopathological changes. The objective of this study is to correlate new, semiautomatic, quantitative features of kidney biopsies (e...
March 14, 2018: BMC Nephrology
Raffaella Mastrocola, Ilario Ferrocino, Erica Liberto, Fausto Chiazza, Alessia Sofia Cento, Debora Collotta, Giulia Querio, Debora Nigro, Valeria Bitonto, Juan Carlos Cutrin, Kalliopi Rantsiou, Mariaconcetta Durante, Emanuela Masini, Manuela Aragno, Chiara Cordero, Luca Cocolin, Massimo Collino
Despite clinical findings suggesting that the form (liquid versus solid) of the sugars may significantly affect the development of metabolic diseases, no experimental data are available on the impact of their formulations on gut microbiota, integrity and hepatic outcomes. In the present sudy, C57Bl/6j mice were fed a standard diet plus water (SD), a standard diet plus 60% fructose syrup (L-Fr) or a 60% fructose solid diet plus water (S-Fr) for 12 weeks. Gut microbiota was characterized through 16S rRNA phylogenetic profiling and shotgun sequencing of microbial genes in ileum content and related volatilome profiling...
February 13, 2018: Journal of Nutritional Biochemistry
Beth Grimmig, Lauren Daly, Meena Subbarayan, Ched Hudson, Robert Williamson, Kevin Nash, Paula C Bickford
Parkinson's disease (PD) is the second most common neurodegenerative disorder and prevalence increases with age. Normal physiological changes that occur during the aging process reflect the pathological characteristics of Parkinson's disease. It is also recognized that age related changes significantly interact with the pathological mechanisms that underlie the neurodegeneration in PD and perpetuate the disease process. Despite the fact that aging is considered to be a primary risk factor for developing PD, the use of aged animal models are still under-utilized in pre-clinical research, thus reducing the translatability of experimental findings...
February 13, 2018: Oncotarget
Paola Mirra, Cecilia Nigro, Immacolata Prevenzano, Alessia Leone, Gregory Alexander Raciti, Pietro Formisano, Francesco Beguinot, Claudia Miele
Glucose serves as a primary, and for some tissues the unique, fuel source in order to generate and maintain the biological functions. Hyperglycemia is a hallmark of type 2 diabetes and is the direct consequence of perturbations in the glucose homeostasis. Insulin resistance, referred to as a reduced response of target tissues to the hormone, contributes to the development of hyperglycemia. The molecular mechanisms responsible for the altered glucose homeostasis are numerous and not completely understood. MicroRNAs (miRNAs) are now recognized as regulators of the lipid and glucose metabolism and are involved in the onset of metabolic diseases...
2018: Frontiers in Endocrinology
Sandro Bartolomei, Federico Nigro, Sandro Ruggeri, Ivan Malagoli Lanzoni, Simone Ciacci, Franco Merni, Eliahu Sadres, Jay R Hoffman, Gabriele Semprini
The purpose of the present study was to validate the ballistic push-up test performed with hands on a force plate (BPU) as a method to measure upper-body power. Twenty-eight experienced resistance trained men (age = 25.4 ± 5.2 y; body mass = 78.5 ± 9.0 kg; body height = 179.6 ± 7.8 cm) performed, two days apart, a bench press 1RM test and upper-body power tests. Mean power and peak power were assessed using the bench press throw test (BT) and the BPU test performed in randomized order. The area under the force/power curve (AUC) obtained at BT was also calculated...
March 6, 2018: Journal of Strength and Conditioning Research
Vincenzo Russo, Andrea Antonio Papa, Anna Rago, Carmine Ciardiello Eng, Gerardo Nigro
BACKGROUND: Atrial fibrillation (AF) is a common finding in myotonic dystrophy type 1 (DM1) population. Pacemakers may facilitate the diagnosis and management of frequent subclinical asymptomatic AF episodes. OBJECTIVE: To evaluate the effect of minimal ventricular pacing (MVP) on paroxysmal AF incidence in DM1 patients during a 24-month follow-up period. METHODS: We enrolled 70 DM1 patients (age 43.4 ± 13.8; 39 F) who underwent dual chamber pacemaker implantation...
March 7, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Michele Pellegrino, Pietro Rizza, Alessandra Nigro, Rosangela Ceraldi, Elena Ricci, Ida Perrotta, Saveria Aquila, Marilena Lanzino, Sebastiano Andò, Catia Morelli, Diego Sisci
Breast cancer (BC) is a complex and heterogeneous disease, with distinct histological features dictating the therapy. Although the clinical outcome of BC patients has been considerably improved, the occurrence of resistance to common endocrine and chemotherapy treatments remains the major cause of relapse and mortality. Thus, efforts in identifying new molecules to be employed in BC therapy are needed. As a "faster" alternative to reach this aim, we evaluated if Lamotrigine (LTG), a broadly used anticonvulsivant, could be "repurposed" as an antitumoral drug in BC...
March 9, 2018: Molecular Cancer Research: MCR
Gaia Grimaldi, Antonio Leo, Angela Nigro, Sandro Pace, Valeria Braccini, Emilio Bellingeri, Carlo Ferdeghini
Anisotropy effects on flux pinning and flux flow are strongly effective in cuprate as well as iron-based superconductors due to their intrinsically layered crystallographic structure. However Fe(Se,Te) thin films grown on CaF2 substrate result less anisotropic with respect to all the other iron based superconductors. We present the first study on the angular dependence of the flux flow instability, which occurs in the flux flow regime as a current driven transition to the normal state at the instability point (I*, V*) in the current-voltage characteristics...
March 7, 2018: Scientific Reports
Silvia Galliazzo, Olga Nigro, Lorenza Bertù, Luigina Guasti, Anna Maria Grandi, Walter Ageno, Francesco Dentali
The prognostic assessment of patients with acute pulmonary embolism (PE) is essential to drive its management. The search for new prognostic factors is a central issue for a more accurate estimate of short-term adverse events. Circulating neutrophils/lymphocytes ratio (NLR) has been suggested as prognostic biomarker for different cardiovascular diseases. Given the central role of inflammation, and in particular of neutrophils in the pathogenesis of VTE and its clinical history, NLR might represent a prognostic tool also in this setting...
March 5, 2018: Internal and Emergency Medicine
Nitish Kamble, Pramod Kumar Pal
Among the involuntary movement disorders, tremor is a common phenomenology seen in clinical practice. The important factors that need to be determined while assessing a patient with tremor include the phenomenology of tremor, presence or absence of other neurologic signs, and the effect of medications or alcohol. Tremor can broadly be classified based on the circumstances under which it occurs, i.e., rest or action. The basal ganglia-cerebello-thalamic and dentate-olivary circuits are involved in the generation of tremor...
March 2018: Neurology India
Vincenzo Russo, Anna Rago, Andrea Antonio Papa, Giulia Arena, Luisa Politano, Gerardo Nigro
BACKGROUND: Atrial electromechanical delay (AEMD) is an echocardiographic parameter correlated with the onset of supraventricular arrhythmias in several clinical conditions. Inter-atrial septal pacing in the region of Bachmann's bundle (BB) has been shown to be safe and feasible in myotonic dystrophy type 1 (DM1) patients, with a low rate of sensing and pacing defects. The aim of this study was to assess the impact of temporary BB pacing compared with right atrial appendage (RAA) pacing on AEMD in DM1 patients undergoing pacemaker (PM) implantation for cardiac rhythm abnormalities...
February 27, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Mark C Anderson, Thibault Chaze, Yves-Marie Coïc, Louise Injarabian, Friederike Jonsson, Naelle Lombion, Dorothée Selimoglu-Buet, Judith Souphron, Caroline Ridley, Pascale Vonaesch, Bruno Baron, Ellen T Arena, Jean-Yves Tinevez, Giulia Nigro, Katharina Nothelfer, Eric Solary, Valérie Lapierre, Thierry Lazure, Mariette Matondo, David Thornton, Philippe J Sansonetti, Françoise Baleux, Benoit S Marteyn
Neutrophils represent the most abundant immune cells recruited to inflamed tissues. A lack of dedicated tools has hampered their detection and study. We show that a synthesized peptide, MUB40 , binds to lactoferrin, the most abundant protein stored in neutrophil-specific and tertiary granules. Lactoferrin is specifically produced by neutrophils among other leukocytes, making MUB40 a specific neutrophil marker. Naive mammalian neutrophils (human, guinea pig, mouse, rabbit) were labeled by fluorescent MUB40 conjugates (-Cy5, Dylight405)...
February 13, 2018: Cell Chemical Biology
Pietro Palmisano, Federico Guerra, Ernesto Ammendola, Matteo Ziacchi, Ennio Carmine Luigi Pisanò, Gabriele Dell'Era, Vittorio Aspromonte, Maria Zaccaria, Francesco Di Ubaldo, Alessandro Capucci, Gerardo Nigro, Eraldo Occhetta, Giampiero Maglia, Renato Pietro Ricci, Giuseppe Boriani, Michele Accogli
BACKGROUND: To determine whether daily physical activity (PA), as measured by implanted devices (through accelerometer sensor), was related to the risk of developing atrial arrhythmias during long-term follow-up in a population of heart failure (HF) patients with an implantable cardioverter defibrillator (ICD). METHODS AND RESULTS: The study population was divided into 2 equally sized groups (PA cutoff point: 3.5 h/d) according to their mean daily PA recorded by the device during the 30- to 60-day period post-ICD implantation...
February 24, 2018: Journal of the American Heart Association
Sandro Bartolomei, Federico Nigro, Luca Gubellini, Simone Ciacci, Franco Merni, Filippo Treno, Matteo Cortesi, Gabriele Semprini
The purpose of the present study was to compare the anthropometric and performance profiles of division I (D1) and division II (D2) Italian field hockey players.Fifteen DI players and fifteen D2 players (age = 25.4 ± 5.2 y; body mass = 78.5 ± 9.0 kg; body height = 179.6 ± 7.8 cm) were assessed on one occasion for anthropometry, body composition, physiological measurements and sport-specific skills. Differences between the two groups were evaluated using a one-way analysis of variance. Pearson correlations were used to examine relationships between the different measurements...
February 20, 2018: Journal of Strength and Conditioning Research
Federico Colombo, Mattia Bastoni, Annamaria Nigro, Paola Podini, Annamaria Finardi, Giacomo Casella, Menon Ramesh, Cinthia Farina, Claudia Verderio, Roberto Furlan
Microvesicles (MVs) are membrane particles of 200-500 nm released by all cell types constitutively. MVs of myeloid origin are found increased in the cerebrospinal fluid (CSF) of patients suffering from neuroinflammatory disorders, although the factors triggering their production have never been defined. Here, we report that both pro- and anti-inflammatory cytokines, specifically interferon-γ and interleukin-4, are equally able to stimulate the production of MVs from microglia cells and monocytes. Additionally, we found this process to be independent from the best characterized molecular pathway so far described for membrane shedding, which is centered on the purinergic receptor P2X7, whose activation by high concentrations of extracellular ATP (exATP) results in membrane blebbing operated by the secreted enzyme acid sphingomyelinase (ASMase)...
2018: Frontiers in Immunology
Barbara Montico, Annunziata Nigro, Vincenzo Casolaro, Jessica Dal Col
Immunogenic apoptosis, or more appropriately called immunogenic cell death (ICD), is a recently described form of apoptosis induced by a specific set of chemotherapeutic drugs or by physical therapeutic modalities, such as ionizing irradiation and photodynamic therapy. The peculiar characteristic of ICD is the ability to favor recognition and elimination of dying tumor cells by phagocytes in association with the release of pro-inflammatory molecules (such as cytokines and high-mobility group box-1). While in vitro and animal models pointed to ICD as one of the molecular mechanisms mediating the clinical efficacy of some anticancer agents, it is hard to clearly demonstrate its contribution in cancer patients...
February 16, 2018: International Journal of Molecular Sciences
Margherita Nannini, Maria Concetta Nigro, Bruno Vincenzi, Elena Fumagalli, Giovanni Grignani, Lorenzo D'Ambrosio, Giuseppe Badalamenti, Lorena Incorvaia, Raffaella Bracci, Silvia Gasperoni, Maristella Saponara, Lidia Gatto, Valentina Indio, Annalisa Astolfi, Valerio Di Scioscio, Paolo G Casali, Giuseppe Tonini, Massimo Aglietta, Antonio Russo, Guido Biasco, Maria A Pantaleo
Background: Regorafenib (REG) has now been approved as the standard third-line therapy in metastatic gastrointestinal stromal tumour (GIST) patients at the recommended dose and schedule of 160 mg once daily for the first 3 weeks of each 4-week cycle. However, it has a relevant toxicity profile that mainly occurs within the first cycles of therapy, and dose and schedule adjustments are often required to reduce the frequency or severity of adverse events and to avoid early treatment discontinuation...
December 2017: Therapeutic Advances in Medical Oncology
E Nigro, P Schettino, R Polito, O Scudiero, M L Monaco, G D De Palma, A Daniele
Adiponectin (Acrp30) is an adipokine widely studied for its beneficial metabolic and anti-inflammatory properties. Colorectal cancer is among the most common cancers worldwide. The aim of present study was to explore the effects of Acrp30 on both CaCo-2 and HCT116 colorectal cancer cells in terms of viability, oxidative stress, and apoptosis. In addition, since colorectal cancer represents a typical inflammation-related cancer, we investigated whether Acrp30 treatment modifies the migration and the expression of crucial proteins in the EMT transition...
February 14, 2018: Molecular and Cellular Biochemistry
Patrik Fazio, Per Svenningsson, Zsolt Cselényi, Christer Halldin, Lars Farde, Andrea Varrone
BACKGROUND: The imaging of biomarkers for characterization of dopaminergic impairment in Parkinson's disease (PD) is useful for diagnosis, patient stratification, and assessment of treatment outcomes. [ 18 F]FE-PE2I is an improved imaging tool allowing for detailed mapping of the dopamine transporter protein in the nigro-striatal system at the level of cell bodies (substantia nigra), axons, and presynaptic terminals (striatum). OBJECTIVES: The objective of this study was to compare the dopamine transporter protein loss in the presynaptic terminals to that in the cell bodies and axons in early PD patients using [ 18 F](E)-N-(3-iodoprop-2-enyl)-2b-carbofluoroethoxy-3b-(4'-methyl-phenyl) nortropane ([ 18 F]FE-PE2I) and high-resolution PET...
February 13, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Marco Savarese, Lorenzo Maggi, Anna Vihola, Per Harald Jonson, Giorgio Tasca, Lucia Ruggiero, Luca Bello, Francesca Magri, Teresa Giugliano, Annalaura Torella, Anni Evilä, Giuseppina Di Fruscio, Olivier Vanakker, Sara Gibertini, Liliana Vercelli, Alessandra Ruggieri, Carlo Antozzi, Helena Luque, Sandra Janssens, Maria Barbara Pasanisi, Chiara Fiorillo, Monika Raimondi, Manuela Ergoli, Luisa Politano, Claudio Bruno, Anna Rubegni, Marika Pane, Filippo M Santorelli, Carlo Minetti, Corrado Angelini, Jan De Bleecker, Maurizio Moggio, Tiziana Mongini, Giacomo Pietro Comi, Lucio Santoro, Eugenio Mercuri, Elena Pegoraro, Marina Mora, Peter Hackman, Bjarne Udd, Vincenzo Nigro
Importance: Mutations in the titin gene (TTN) cause a wide spectrum of genetic diseases. The interpretation of the numerous rare variants identified in TTN is a difficult challenge given its large size. Objective: To identify genetic variants in titin in a cohort of patients with muscle disorders. Design, Setting, and Participants: In this case series, 9 patients with titinopathy and 4 other patients with possibly disease-causing variants in TTN were identified...
February 12, 2018: JAMA Neurology
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