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Elena Cavarretta, Francesco Maffessanti, Fabio Sperandii, Emanuele Guerra, Federico Quaranta, Antonia Nigro, Monia Minati, Marco Rebecchi, Chiara Fossati, Leonardo Calò, Fabio Pigozzi
Background Several articles have proposed reference values in healthy paediatric subjects, but none of them has evaluated a large population of healthy trained adolescents. Design The study purpose was to establish normal echocardiographic measurements of left heart (aortic root, left atrium and left ventricular dimensions and mass) in relation to age, weight, height, body mass index, body surface area and training hours in this specific population. Methods We retrospectively evaluated 2151 consecutive, healthy, peri-pubertal athletes (100% male, mean age 12...
January 1, 2018: European Journal of Preventive Cardiology
Robert E Hynds, Kate H C Gowers, Ersilia Nigro, Colin R Butler, Paola Bonfanti, Adam Giangreco, Cecilia M Prêle, Sam M Janes
There is considerable interest in the ex vivo propagation of primary human basal epithelial stem/progenitor cells with a view to their use in drug development, toxicity testing and regenerative medicine. These cells can be expanded in co-culture with mitotically inactivated 3T3-J2 murine embryonic feeder cells but, similar to other epithelial cell culture systems employing 3T3-J2 cells, the aspects of cross-talk between 3T3-J2 cells and human airway basal cells that are critical for their expansion remain largely unknown...
2018: PloS One
G Aquila, M B Morelli, F Vieceli Dalla Sega, F Fortini, P Nigro, C Caliceti, M Ferracin, M Negrini, A Pannuti, M Bonora, P Pinton, R Ferrari, P Rizzo
Ivabradine, a heart rate reducing agent, protects the vascular system by unidentified mechanisms. We sought to determine the effects of the treatment with ivabradine, started before plaque formation, on early transcriptional changes and endothelium lesions in regions of aorta subjected to disturbed blood flow. Six week-old apolipoprotein E-deficient (ApoE-/- ) mice, fed a low-fat diet, were treated with ivabradine to determine the effect on transcriptional changes (2-and 4-week treatment) and on lesions formation (19-week treatment) in the endothelium of the aortic arch...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Carmine Muto, Francesco Solimene, Vincenzo Russo, Gerardo Nigro, Anna Rago, Raffaele Chianese, Paola Chiariello, Carmine Ciardiello, Luigi Caliendo
AIM: To evaluate at a 12-month follow-up, the clinical and echocardiographic outcomes in postmyocardial infarction (MI) heart failure patients who underwent cardiac resynchronization therapy (CRT) device implantation. MATERIALS & METHODS: A total of 100 patients received a CRT device, and the study population was divided into three groups, according to the site of MI and left ventricular (LV) lead placed downstream of the ischemic area, as evaluated by echocardiography...
May 16, 2018: Future Cardiology
Roberta Brusa, Francesca Magri, Dimitra Papadimitriou, Alessandra Govoni, Roberto Del Bo, Patrizia Ciscato, Marco Savarese, Claudia Cinnante, Maggie C Walter, Angela Abicht, Stefanie Bulst, Stefania Corti, Maurizio Moggio, Nereo Bresolin, Vincenzo Nigro, Giacomo Pietro Comi
Limb girdle muscular dystrophy (LGMD) type 2G is a rare form of muscle disease, described only in a few patients worldwide, caused by mutations in TCAP gene, encoding the protein telethonin. It is characterised by proximal limb muscle weakness associated with distal involvement of lower limbs, starting in the first or second decade of life. We describe the case of a 37-year-old woman of Greek origin, affected by disto-proximal lower limb weakness. No cardiac or respiratory involvement was detected. Muscle biopsy showed myopathic changes with type I fibre hypotrophy, cytoplasmic vacuoles, lipid overload, multiple central nuclei and fibre splittings; ultrastructural examination showed metabolic abnormalities...
April 13, 2018: Neuromuscular Disorders: NMD
Benjamin Weismüller, Marta Ghio, Kazimierz Logmin, Christian Hartmann, Alfons Schnitzler, Bettina Pollok, Martin Südmeyer, Christian Bellebaum
Phasic dopamine (DA) signals conveyed from the substantia nigra to the striatum and the prefrontal cortex crucially affect learning from feedback, with DA bursts facilitating learning from positive feedback and DA dips facilitating learning from negative feedback. Consequently, diminished nigro-striatal dopamine levels as in unmedicated patients suffering from Parkinson's Disease (PD) have been shown to lead to a negative learning bias. Recent studies suggested a diminished striatal contribution to feedback processing when the outcome of an action is temporally delayed...
May 11, 2018: Neuropsychologia
Pasquale Donnarumma, Lorenzo Nigro, Angela Ambrosone, Roberto Tarantino, Antonio Santoro, Roberto Delfini
No abstract text is available yet for this article.
May 9, 2018: Journal of Neurosurgical Sciences
Tracey Lynn Nigro
This article outlines personality traits such as psychopathy, narcissism, Machiavellianism, and sadism which, when elevated in health leaders, may have negative effects upon teams, the organizations they work for, and ultimately the public. The implications of such traits for specific core health leadership competency domains are explored as well as potential mitigation approaches to minimize and possibly redirect such personality traits.
May 2018: Healthcare Management Forum
Davide Viggiano, Giuseppe Gigliotti, Gianfranco Vallone, Anna Giammarino, Michelangelo Nigro, Giovambattista Capasso
Current urate-lowering therapy (ULT) includes three direct acting drugs (allopurinol, febuxostat, Rasburicase) and at least four 'indirect' drugs with other important targets (canagliflozin, losartan, fenofibrate and sevelamer). Moreover, the alcalinization of urines using bicarbonate can be used to dissolve urate crystals and the clinician may discontinue several drugs are known to increase serum levels of uric acid, such as diuretics, aspirin, cyclosporine, theophylline, mycophenolate and ACE inhibitors. While there is a consensus to start ULT in cases of symptomatic hyperuricemia (gout, urate-nephrolithiasis), the very frequent conditions of asymptomatic hyperuricemia remains a major conundrum...
April 19, 2018: Kidney & Blood Pressure Research
Alessandro Rimessi, Valentino Bezzerri, Francesca Salvatori, Anna Tamanini, Federica Nigro, Maria Cristina Dechecchi, Alessandra Santangelo, Paola Prandini, Silvia Munari, Lisa Provezza, Nicolas Garreau de Loubresse, Jean Muller, Carla M P Ribeiro, Giuseppe Lippi, Roberto Gambari, Paolo Pinton, Giulio Cabrini
An excessive inflammation orchestrated by release of neutrophilic chemokine IL-8 from bronchial epithelial cells, amplified by Pseudomonas aeruginosa (P. aeruginosa) infection, is a hallmark of lung disease of Cystic Fibrosis (CF) patients. To identify novel anti-inflammatory molecular targets, we previously performed a genetic study of 135 genes of the immune response, which identified the c.2534C>T (p.S845L) variant of phospholipase C beta 3 (PLCB3) as being significantly associated with mild progression of pulmonary disease...
April 18, 2018: American Journal of Respiratory Cell and Molecular Biology
Stefano Tomassi, Caterina Ieranò, Maria Emilia Mercurio, Ersilia Nigro, Aurora Daniele, Rosita Russo, Angela Chambery, Ilaria Baglivo, Paolo Vincenzo Pedone, Giuseppina Rea, Maria Napolitano, Stefania Scala, Sandro Cosconati, Luciana Marinelli, Ettore Novellino, Anna Messere, Salvatore Di Maro
Cationic nucleopeptides belong to a family of synthetic oligomers composed by amino acids and nucleobases. Their capability to recognize nucleic acid targets and to cross cellular membranes provided the basis for considering them as novel non-covalent delivery agents for nucleic acid pharmaceuticals. Herein, starting from a 12-mer nucleopeptide model, the number of cationic residues was modulated in order to obtain new nucleopeptides endowed with high solubility in acqueous medium, acceptable bio-stability, low cytotoxicity and good capability to bind nucleic acid...
April 7, 2018: Bioorganic & Medicinal Chemistry
Antonietta Messina, Marcellino Monda, Anna Valenzano, Giovanni Messina, Ines Villano, Fiorenzo Moscatelli, Giuseppe Cibelli, Gabriella Marsala, Rita Polito, Maria Ruberto, Marco Carotenuto, Vincenzo Monda, Andrea Viggiano, Aurora Daniele, Ersilia Nigro
Obesity and lifestyle-related diseases are major problems faced by people in developed nations. Although exercise training prevents the progression of diabetes and obesity, the motivation for exercise is generally low in obese animals and humans. The autonomic nervous system (SNA) plays a crucial role in the regulation of eating behavior. Moreover, the SNA is involved in the body temperature regulation that is strictly related to body weight control, in accordance with the "thermoregulatory hypothesis" of food intake...
2018: Frontiers in Physiology
Mariaclaudia Meli, Manuela Caruso-Nicoletti, Milena La Spina, Luca Lo Nigro, Piera Samperi, Salvatore D'Amico, Francesco Bellia, Vito Miraglia, Maria Licciardello, Emanuela Cannata, Silvia Marino, Carla Cimino, Federica Puglisi, Laura Lo Valvo, Agnese Pezzulla, Giovanna Russo, Andrea Di Cataldo
BACKGROUND: Triptorelin, a gonadotropin releasing hormone analogue, can be administered to postpubertal female individuals with cancer who receive chemotherapy to obtain menstrual suppression and decrease the risk of hemorrhage caused by thrombocytopenia. Our goal was to assess whether triptorelin also has a protective role against the gonadotoxicity of chemotherapy. PATIENTS AND METHODS: This retrospective observational study includes all postmenarchal female patients who presented to our Unit from 2000 to 2015 and received chemotherapy for cancer...
April 3, 2018: Journal of Pediatric Hematology/oncology
Mateus Trinconi Cunha, Maria Aparecida Murça, Stanley Nigro, Giselle Burlamaqui Klautau, Mauro José Costa Salles
BACKGROUND: Conventional local treatment for medullary osteomyelitis (OM) includes insertion of antibiotic-loaded polymethylmethacrylate (PMMA) cement. Nevertheless, PMMA may delivery irregular concentration of antibiotic to surrounding tissue. We aimed to compare the in vitro antibacterial activity of Bioactive Glass (BAG) S53P4, which is a compound showing local antibacterial activity, to that of antibiotic-loaded PMMA against multidrug resistant bacteria from OM isolates. METHODS: We studied convenience samples of multidrug resistant (MDR) microorganisms obtained from patients presenting OM and prosthetic joint infection (PJI)...
April 3, 2018: BMC Infectious Diseases
Ausilia Elce, Ersilia Nigro, Monica Gelzo, Paola Iacotucci, Vincenzo Carnovale, Renato Liguori, Viviana Izzo, Gaetano Corso, Giuseppe Castaldo, Aurora Daniele, Federica Zarrilli
OBJECTIVE: cystic fibrosis (CF) is the most common inherited, life limiting condition among Caucasians. No healing therapy is currently available for patients with CF. The aim of the study was to define clinical, anthropometric and biochemical effects of regular, supervised physical exercise in a large cohort of patients with CF. MATERIALS AND METHODS: 59 adult patients with CF that performed regularly supervised physical exercise in the last three years in comparison to 59 sex and age matched sedentary patients with CF were included in the study...
March 30, 2018: Clinical Respiratory Journal
Gregory Alexander Raciti, Francesca Fiory, Michele Campitelli, Antonella Desiderio, Rosa Spinelli, Michele Longo, Cecilia Nigro, Giacomo Pepe, Eduardo Sommella, Pietro Campiglia, Pietro Formisano, Francesco Beguinot, Claudia Miele
Metabolic and/or endocrine dysfunction of the white adipose tissue (WAT) contribute to the development of metabolic disorders, such as Type 2 Diabetes (T2D). Therefore, the identification of products able to improve adipose tissue function represents a valuable strategy for the prevention and/or treatment of T2D. In the current study, we investigated the potential effects of dry extracts obtained from Citrus aurantium L. fruit juice (CAde) on the regulation of 3T3-L1 cells adipocyte differentiation and function in vitro...
2018: PloS One
Christopher A Bourke
Sporadic or idiopathic Parkinson's disease is a movement disorder with a worldwide distribution, a long pre-clinical latent period and a frequent association with dementia. The combination of molybdenum deficiency and purine ingestion could explain the movement disorder, the distribution, the latent period and the dementia association. Recent studies in sheep have shown that molybdenum deficiency enables some dietary purines to accumulate in the central nervous system. This causes astrocyte dysfunction, altered neuromodulation and eventually irreversible central nervous system disease...
2018: NPJ Parkinson's Disease
Vincenzo Russo, Andrea Antonio Papa, Anna Rago, Carmine Ciardiello, Marco Marano, Riccardo Proietti, Luisa Politano, Gerardo Nigro
Paroxysmal atrial fibrillation frequently occurs in Myotonic dystrophy type 1 (DM1) patients. Interatrial block is recognized as predictor of atrial arrhythmias, particularly atrial fibrillation (AF). The aim of this study was to evaluate the role of interatrial block in predicting the onset of atrial fibrillation during 2-year follow-up in DM1 patients who underwent pacemaker implantation for conduction system disorders. The study prospectively enrolled 70 DM1 patients (aged 36-69; 31 M) who underwent pacemaker implantation for cardiac rhythm abnormalities in accordance with the current guidelines...
January 31, 2018: Neuromuscular Disorders: NMD
Nicole A Hynson, Kiana L Frank, Rosanna A Alegado, Anthony S Amend, Mohammad Arif, Gordon M Bennett, Andrea J Jani, Matthew C I Medeiros, Yuriy Mileyko, Craig E Nelson, Nhu H Nguyen, Olivia D Nigro, Sladjana Prisic, Sangwoo Shin, Daisuke Takagi, Samuel T Wilson, Joanne Y Yew
Despite increasing acknowledgment that microorganisms underpin the healthy functioning of basically all multicellular life, few cross-disciplinary teams address the diversity and function of microbiota across organisms and ecosystems. Our newly formed consortium of junior faculty spanning fields such as ecology and geoscience to mathematics and molecular biology from the University of Hawai'i at Mānoa aims to fill this gap. We are united in our mutual interest in advancing a new paradigm for biology that incorporates our modern understanding of the importance of microorganisms...
March 2018: MSystems
Gaetano Barbagallo, Rita Nisticò, Basilio Vescio, Antonio Cerasa, Giuseppe Olivadese, Salvatore Nigro, Marianna Crasà, Andrea Quattrone, Maria Giovanna Bianco, Maurizio Morelli, Antonio Augimeri, Maria Salsone, Fabiana Novellino, Giuseppe Nicoletti, Gennarina Arabia, Aldo Quattrone
INTRODUCTION: The aim of our study was to investigate the effect of apomorphine and placebo on resting tremor in tremor-dominant Parkinson's disease (tPD) patients. METHODS: Fifteen tPD patients were enrolled. Each patient underwent two treatments on two consecutive days: on day one the patients received a subcutaneous injection of placebo, while on day two they received apomorphine. On each day, the patients underwent three electrophysiological recording sessions: T0, T1, and T2: before, 30 min, and 60 min after the treatment respectively...
March 14, 2018: Parkinsonism & related Disorders
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