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https://www.readbyqxmd.com/read/28541963/correlation-of-structural-and-functional-outcome-measures-in-a-phase-one-trial-of-ciliary-neurotrophic-factor-in-type-2-idiopathic-macular-telangiectasia
#1
Ferenc B Sallo, Irene Leung, Traci E Clemons, Tunde Peto, Emily Y Chew, Daniel Pauleikhoff, Alan C Bird
PURPOSE: Macular telangiectasia Type 2 is a bilateral, progressive, potentially blinding retinal disease characterized by both vascular and neurodegenerative signs. Both the area of the break in the ellipsoid zone seen in "en face" optical coherence tomographic (OCT) images and microperimetric focal retinal sensitivity loss have been proposed as potential measures of progression in macular telangiectasia. The authors aimed to assess the characteristics and interrelationship of these structural and functional disease markers from the data collected in a phase one clinical trial of ciliary neurotrophic factor in macular telangiectasia...
May 23, 2017: Retina
https://www.readbyqxmd.com/read/28540376/on-the-local-order-of-amorphous-la2mo2o6-7
#2
Jesús Vega-Castillo, Gaëtan Buvat, Gwenaël Corbel, Abdelhadi Kassiba, Philippe Lacorre, Alberto Caneiro
The amorphous reduction product of the oxide ion conductor La2Mo2O9 was previously shown to be a good, sulphur-tolerant, anode material for solid oxide fuel cell devices (X. C. Lu, J. H. Zhu, J. Electrochem. Soc., 2008, 155(10), B1053). In this paper, we study the local order of amorphous La2Mo2O6.7 using X-ray absorption spectroscopy analyses and electronic paramagnetic resonance. The extended X-ray absorption fine structure analysis of local arrangements around Mo in La2Mo2O6.7 is first carried out on the basis of strong distortions from three crystalline models of La2Mo2O9, La7Mo7O30 and La2Mo2O7...
May 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28537998/lactate-and-microcirculation-as-suitable-targets-for-hemodynamic-optimization-in-resuscitation-of-circulatory-shock
#3
Michael E Kiyatkin, Jan Bakker
PURPOSE OF REVIEW: A discussion of recent research exploring the feasibility of perfusion-guided resuscitation of acute circulatory failure with a focus on lactate and microcirculation. RECENT FINDINGS: Upon diagnosis of shock, hyperlactemia is associated with poor outcome and, under appropriate clinical circumstances, may reflect inadequate tissue perfusion. Persistent hyperlactemia despite resuscitation is even more strongly correlated with morbidity and mortality...
May 22, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28537635/growth-of-bifeo3-thin-films-by-chemical-solution-deposition-the-role-of-electrodes
#4
Monika Tomczyk, Daniel G Stroppa, Ian M Reaney, Paula M Vilarinho
BiFeO3 (BFO) thin films were grown by chemical solution deposition on a range of electrodes to determine their role in controlling the phase formation and microstructure of the films. The crystallization on oxide electrodes followed the sequence: amorphous → Bi2O2(CO3) → perovskite, while those on Pt crystallized directly from the amorphous phase. IrO2 electrodes promoted perovskite phase formation at the lowest temperature and LaNiO3 additionally induced local epitaxial growth. All compositions exhibited fully coherent Fe-rich precipitates within the grain interior of the perovskite matrix, whereas the incoherent Bi2Fe4O9 second phase was also observed at the grain boundaries of BFO grown on Pt electrodes...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28536832/proteomic-profiling-reveals-crucial-retinal-protein-alterations-in-the-early-phase-of-an-experimental-glaucoma-model
#5
Fabian Anders, Julia Teister, Sebstian Funke, Norbert Pfeiffer, Franz Grus, Thanos Solon, Verena Prokosch
PURPOSE: Clinical glaucoma is difficult to assess in terms of molecular pathophysiology, prompting studies in experimental models of glaucoma. The purpose of this study was to investigate quantitative changes in retinal protein expression at the onset of experimental glaucoma in rats. Analyzing the proteome provides a suitable tool to decipher the pathophysiological processes in glaucomatous degeneration. METHODS: Thermic cauterization of episcleral veins was utilized to elevate the intraocular pressure in Sprague Dawley rats...
May 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28536457/controlling-quantum-interference-in-phase-space-with-amplitude
#6
Yinghong Xue, Tingyu Li, Katsuyuki Kasai, Yoshiko Okada-Shudo, Masayoshi Watanabe, Yun Zhang
We experimentally show a quantum interference in phase space by interrogating photon number probabilities (n = 2, 3, and 4) of a displaced squeezed state, which is generated by an optical parametric amplifier and whose displacement is controlled by amplitude of injected coherent light. It is found that the probabilities exhibit oscillations of interference effect depending upon the amplitude of the controlling light field. This phenomenon is attributed to quantum interference in phase space and indicates the capability of controlling quantum interference using amplitude...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28534489/long-term-mutual-phase-locking-of-picosecond-pulse-pairs-generated-by-a-semiconductor-nanowire-laser
#7
B Mayer, A Regler, S Sterzl, T Stettner, G Koblmüller, M Kaniber, B Lingnau, K Lüdge, J J Finley
The ability to generate phase-stabilized trains of ultrafast laser pulses by mode-locking underpins photonics research in fields, such as precision metrology and spectroscopy. However, the complexity of conventional mode-locked laser systems has hindered their realization at the nanoscale. Here we demonstrate that GaAs-AlGaAs nanowire lasers are capable of emitting pairs of phase-locked picosecond laser pulses with a repetition frequency up to 200 GHz when subject to incoherent pulsed optical excitation. By probing the two-pulse interference spectra, we show that pulse pairs remain mutually coherent over timescales extending to 30 ps, much longer than the emitted laser pulse duration (≤3 ps)...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28531091/ab-initio-studies-of-coherent-spin-transport-in-fe-hbn-graphene-van-der-waals-multilayers
#8
Aniekan Ukpong
This paper presents the results of ab initio studies of the electronic spin manipulation, inversion, filtering and transport using a ferromagnetic multilayer heterostructure. Spin-polarized electronic structure calculations are performed based on van der Waals density functional theory to give unique insights to the generation, manipulation and transport of coherent spin conductance. By using an exact theory of the self-consistent ground state of the Fe-hBN/graphene multilayer as a model of the magnetic tunnel junction, this paper unravels the hidden asymmetries in the spin-resolved charge densities...
May 22, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28530835/on-the-formation-of-epitaxially-connected-quantum-dot-solids-nucleation-and-coherent-phase-transition
#9
Kevin Whitham, Tobias Hanrath
The formation of epitaxially connected quantum dot solids involves a complex interplay of interfacial assembly, surface chemistry, and irreversible directed attachment. We describe the basic mechanism in context of a coherent phase transition with distinct nucleation and propagation steps. The proposed mechanism explains how defects in the pre-assembled structure influence nucleation and how basic geometric relationships govern the transformation from hexagonal assemblies of isolated dots to interconnected solids with square symmetry...
May 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28529877/the-dynamics-of-functional-connectivity-in-neocortical-focal-epilepsy
#10
Mangor Pedersen, Amir Omidvarnia, Evan K Curwood, Jennifer M Walz, Genevieve Rayner, Graeme D Jackson
Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture brain network activity at the maximal temporal resolution of the acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods of brain voxels. We use it here to examine how the dynamics of the functional connections of regional brain networks are altered in neocortical focal epilepsy...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28528901/responses-to-spatial-contrast-in-the-mouse-suprachiasmatic-nuclei
#11
Joshua W Mouland, Adam R Stinchcombe, Daniel B Forger, Timothy M Brown, Robert J Lucas
A direct retinal projection targets the suprachiasmatic nucleus (SCN) (an important hypothalamic control center). The accepted function of this projection is to convey information about ambient light (irradiance) to synchronize the SCN's endogenous circadian clock with local time and drive the diurnal variations in physiology and behavior [1-4]. Here, we report that it also renders the SCN responsive to visual images. We map spatial receptive fields (RFs) for SCN neurons and find that only a minority are excited (or inhibited) by light from across the scene as expected for irradiance detectors...
May 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28527912/implicit-variations-of-temporal-predictability-shaping-the-neural-oscillatory-and-behavioural-response
#12
Sophie K Herbst, Jonas Obleser
Being able to predict when an event will occur (temporal predictability) can help us prepare and time our responses. We here sought to delineate the neural and behavioural corollaries of highly implicit, probabilistic temporal predictability in an auditory foreperiod paradigm. To this end, we measured electroencephalography (EEG) and response times in two independent experiments (total N = 46). Unbeknownst to participants, we induced a probabilistic variation of cue-target delays (i.e., foreperiods) in a pitch-discrimination task on a noise-embedded tone: The smaller the standard deviation of the underlying foreperiod distribution, the more predictable the time of target occurrence should be...
May 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28526865/realization-of-large-energy-proportion-in-the-central-lobe-by-coherent-beam-combination-based-on-conformal-projection-system
#13
Dong Zhi, Zhixin Zhang, Yanxing Ma, Xiaolin Wang, Zilun Chen, Wuming Wu, Pu Zhou, Lei Si
In this paper, we experimentally validate a tiled-aperture conformal projection system with the largest array filling factor and element beam truncation factor to the best of our knowledge. The conformal projection system, which is made up of a hexagonal adaptive fiber-optics collimator (AFOC) array with the proximate ideal intensity distributions, is fabricated and the performance of output beam is tested and evaluated properly and carefully. Both of the active phase-locking control and precise tip-tilt control are implemented successfully in the CBC of the hexagonal seven-beam-array...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28525561/decade-long-profile-of-imaging-biomarker-use-in-ophthalmic-clinical-trials
#14
Edoardo Villani, Domenico Massaro, Matteo Scaramuzzi, Pedram Hamrah, Felipe A Medeiros, Paolo Nucci
Purpose: The purpose of this study was to investigate the use of imaging biomarkers in published clinical trials (CTs) in ophthalmology and its eventual changes during the past 10 years. Methods: We sampled from published CTs in the fields of cornea, retina, and glaucoma between 2005-2006 and 2015-2016. Data collected included year of publication, phase, subspecialty, location, compliance with Consolidated Standards for Reporting Trials, impact factor, presence and use of imaging biomarkers (diagnostic, prognostic and predictive; primary and secondary surrogate endpoints), and use of centralized reading centers...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28524683/return-to-the-origin-as-a-probe-of-atomic-phase-coherence
#15
Clément Hainaut, Isam Manai, Radu Chicireanu, Jean-François Clément, Samir Zemmouri, Jean Claude Garreau, Pascal Szriftgiser, Gabriel Lemarié, Nicolas Cherroret, Dominique Delande
We report on the observation of the coherent enhancement of the return probability ["enhanced return to the origin" (ERO)] in a periodically kicked cold-atom gas. By submitting an atomic wave packet to a pulsed, periodically shifted, laser standing wave, we induce an oscillation of ERO in time that is explained in terms of a periodic, reversible dephasing in the weak-localization interference sequences responsible for ERO. Monitoring the temporal decay of ERO, we exploit its quantum-coherent nature to quantify the decoherence rate of the atomic system...
May 5, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28524674/holography-of-wi-fi-radiation
#16
Philipp M Holl, Friedemann Reinhard
Wireless data transmission systems such as wi-fi or Bluetooth emit coherent light-electromagnetic waves with a precisely known amplitude and phase. Propagating in space, this radiation forms a hologram-a two-dimensional wave front encoding a three-dimensional view of all objects traversed by the light beam. Here we demonstrate a scheme to record this hologram in a phase-coherent fashion across a meter-sized imaging region. We recover three-dimensional views of objects and emitters by feeding the resulting data into digital reconstruction algorithms...
May 5, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28524203/time-resolved-photoelectron-spectroscopy-of-ir-driven-electron-dynamics-in-a-charge-transfer-model-system
#17
Mirjam Falge, Friedrich Georg Fröbel, Volker Engel, Stefanie Gräfe
If the adiabatic approximation is valid, electrons smoothly adapt to molecular geometry changes. In contrast, as a characteristic of diabatic dynamics, the electron density does not follow the nuclear motion. Recently, we have shown that the asymmetry in time-resolved photoelectron spectra serves as a tool to distinguish between these dynamics [Falge et al., J. Phys. Chem. Lett., 2012, 3, 2617]. Here, we investigate the influence of an additional, moderately intense infrared (IR) laser field, as often applied in attosecond time-resolved experiments, on such asymmetries...
May 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28522820/microstructures-mechanical-behavior-and-strengthening-mechanism-of-tisicn-nanocomposite-films
#18
Wei Li, Ping Liu, Zenghui Xue, Fengcang Ma, Ke Zhang, Xiaohong Chen, Rui Feng, Peter K Liaw
Currently, the arguments have existed in the strengthening mechanism and microstructural model of the nanocomposite film due to lack of the convincible experimental evidences. In this investigation, the quarternary TiSiCN nanocomposite films with the different C and Si contents are synthesized by the reactive-magnetron-sputtering technique. The TiSiCN film is characterized as the nanocomposite structure with the TiN nanocrystallites surrounded by the (Si3N4 + C + CNx) interface phase. When the C/Si content ratio is 2:2, the TiSiCN nanocomposite film is remarkably strengthened with the maximal hardness and elastic modulus of 46...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521331/retinal-deep-capillary-ischemia-associated-with-an-occluded-congenital-retinal-macrovessel
#19
Taiji Hasegawa, Nahoko Ogata
PURPOSE: To report the case of a patient with an occluded congenital retinal macrovessel accompanied by retinal deep capillary ischemia. METHODS: A 38-year-old woman presented with a 2-day history of a paracentral scotoma of her right eye. RESULTS: Fundus photograph showed a dilated congenital retinal macrovessel with arteriovenous anastomosis, an intravascular white region indicating the thrombus at arteriovenous anastomotic region, and an area of retinal whitening temporal to the fovea...
July 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28521049/22q11-2-deletion-syndrome-is-associated-with-impaired-auditory-steady-state-gamma-response
#20
Kit Melissa Larsen, Giovanni Pellegrino, Michelle Rosgaard Birknow, Trine Nørgaard Kjær, William Frans Christiaan Baaré, Michael Didriksen, Line Olsen, Thomas Werge, Morten Mørup, Hartwig Roman Siebner
Background: The 22q11.2 deletion syndrome confers a markedly increased risk for schizophrenia. 22q11.2 deletion carriers without manifest psychotic disorder offer the possibility to identify functional abnormalities that precede clinical onset. Since schizophrenia is associated with a reduced cortical gamma response to auditory stimulation at 40 Hz, we hypothesized that the 40 Hz auditory steady-state response (ASSR) may be attenuated in nonpsychotic individuals with a 22q11.2 deletion...
May 17, 2017: Schizophrenia Bulletin
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