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"Prediction" AND "pre-eclampsia"

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https://www.readbyqxmd.com/read/29766818/cell-free-fetal-dna-a-novel-biomarker-for-early-prediction-of-pre-eclampsia-and-other-obstetric-complications
#1
Naina Kumar, Amit Kant Singh
Hypertensive disorder of pregnancy, especially Pre-eclampsia is one of the major causes of increased maternal and perinatal morbidity and mortality all over the world. Early prediction of pre-eclampsia is the need of modern obstetrics, as this can timely prevent the progress of disease as well as related fetal and maternal morbidity and mortality. In addition to the screening of fetal aneuploidies, Rhesus-D status, fetal sex, single gene disorders, the cell-free fetal Deoxyribonucleic acid (DNA) quantification has emerged out as a promising biomarker for prediction of pre-eclampsia...
May 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29737875/the-discovery-of-protein-biomarkers-in-pre-eclmmpsia-the-promising-role-of-mass-spectrometry
#2
Lina A Dahabiyeh
CONTEXT: Pre-eclampsia (PE) is a common hypertensive disorder of pregnancy that substantially affects maternal and neonatal morbidity and mortality worldwide. The etiology of the disease remains poorly understood with lack of reliable diagnostic tests. PE is a multisystem disorder so it is very unlikely that a single or a small group of biomarkers will accurately predict the disease. Mass spectrometry (MS) is indispensable analytical tool in protein analysis studies. MS-based proteomics have the ability to detect the entire protein complement to provide a useful window into a range of biological processes and allow the identification of differentially expressed proteins between samples...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29700870/the-cost-effectiveness-of-first-trimester-screening-and-early-preventative-use-of-aspirin-in-women-at-high-risk-of-early-onset-pre-eclampsia
#3
Dayne Ortved, T Lee-Ann Hawkins, Jo-Ann Johnson, Jon Hyett, Amy Metcalfe
OBJECTIVE: Pre-eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. A first trimester screening algorithm predicting the risk of early onset PE has been developed and validated. Early prediction coupled with initiation of aspirin at 11 to 13 weeks in women identified as high risk is effective at reducing the prevalence of early onset PE. The aim of this study is to evaluate the cost-effectiveness of this first trimester screening program coupled with early use of low-dose aspirin in women at high risk of developing early onset PE versus current practice...
April 27, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29686379/maternal-early-pregnancy-obesity-and-related-pregnancy-and-pre-pregnancy-disorders-associations-with-child-developmental-milestones-in-the-prospective-predo-study
#4
Polina Girchenko, Soile Tuovinen, Marius Lahti-Pulkkinen, Jari Lahti, Katri Savolainen, Kati Heinonen, Riikka Pyhälä, Rebecca M Reynolds, Esa Hämäläinen, Pia M Villa, Eero Kajantie, Anu-Katriina Pesonen, Hannele Laivuori, Katri Räikkönen
BACKGROUND/OBJECTIVES: Previous studies have linked maternal pre-pregnancy obesity (BMI ≥30 kg/m2 ) with suboptimal neurodevelopment in her offspring; however, the literature is not entirely consistent. Whether these effects are muddled by maternal self-reports of pre-pregnancy weight and height, or are driven or amplified by the well often comorbid hypertensive and diabetic pregnancy and pre-pregnancy disorders, remains unclear. We examined whether maternal early pregnancy obesity is associated with developmental delay in her offspring, and if the associations are driven or amplified by diabetic and hypertensive pregnancy and pre-pregnancy disorders...
April 23, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29667739/maternal-depressive-symptoms-during-and-after-pregnancy-and-child-developmental-milestones
#5
Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Jari Lipsanen, Jari Lahti, Kati Heinonen, Rebecca M Reynolds, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Anu-Katriina Pesonen, Pia M Villa, Katri Räikkönen
BACKGROUND: Maternal depressive symptoms during and after pregnancy predict poorer child neurodevelopment. The effects of timing, symptom severity, and additive influences remain unclear. METHODS: A total of 2,231 mothers of the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiological Studies Depression Scale biweekly up to 14 times during pregnancy and twice up to 12 months after pregnancy...
April 18, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29643944/competing-endogenous-rna-expression-profiling-in-pre-eclampsia-identifies-hsa_circ_0036877-as-a-potential-novel-blood-biomarker-for-early-pre-eclampsia
#6
Xiaopeng Hu, Junping Ao, Xinyue Li, Huijuan Zhang, Ji Wu, Weiwei Cheng
Background: The etiology and pathogenesis of pre-eclampsia (PE) is unclear, and there is no ideal early clinical biomarker for prediction of PE. The competing endogenous RNA (ceRNA) hypothesis is a new approach to uncover the molecular pathology of PE. The first aim of this study was to perform messenger RNA, long non-coding RNA, and circular RNA (circRNA) expression profiling of human normal and severe pre-eclampsia (SPE) placentas. circRNA, which has a stable structure, is a more suitable biomarker than other types of RNA...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29575304/performance-of-commercially-available-placental-growth-factor-tests-in-women-with-suspected-preterm-pre-eclampsia-the-compare-study
#7
F P McCarthy, C Gill, P T Seed, K Bramham, L C Chappell, A H Shennan
OBJECTIVE: To compare the performance of three PlGF-based kits in prediction of time to delivery within 14 days in women with suspected preterm pre-eclampsia prior to 35 weeks' gestation. METHODS: We conducted a retrospective analysis of samples collected from three prospective pregnancy cohort studies. Participants were pregnant women with suspected preterm pre-eclampsia recruited in tertiary maternity units in the UK and Ireland. Samples were analysed simultaneously according to manufacturer's directions...
March 25, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29567337/biomarkers-of-glomerular-dysfunction-in-pre-eclampsia-a-systematic-review
#8
REVIEW
Robert N Kerley, Cathal McCarthy
BACKGROUND: Early detection of pre-eclampsia remains one of the major focuses of antenatal obstetric care. There is often a delay in the diagnosis, mainly due to the non-specific nature of the condition. Podocytes which play a pivotal role in glomerular function become injured in pre-eclampsia leading to subsequent proteinuria. Our aim was to review available studies to determine the clinical utility of biomarkers of podocyte injury in pre-eclampsia. METHODS: We used QUADAS (Quality Assessment of Diagnostic Accuracy Studies) criteria to perform a systematic review of the literature to determine the clinical utility of podocyte injury biomarkers in predicting pre-eclampsia...
March 10, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29560262/recent-advances-in-the-diagnosis-and-management-of-pre-eclampsia
#9
REVIEW
Kate Duhig, Brooke Vandermolen, Andrew Shennan
Pre-eclampsia is a leading cause of maternal mortality, responsible annually for over 60,000 maternal deaths around the globe. Pre-eclampsia is a multisystem disease featuring hypertension, proteinuria, and renal, hepatic, and neurological involvement. Diagnosis is often elusive, as clinical presentation is highly variable. Even those with severe disease can remain asymptomatic. Angiogenic factors are emerging as having a role in the diagnosis of pre-eclampsia and in prognostication of established disease. In this article, we summarize new developments and focus on angiogenic biomarkers for prediction of disease onset...
2018: F1000Research
https://www.readbyqxmd.com/read/29537127/successful-pregnancy-outcomes-following-liver-transplantation-is-predicted-by-renal-function
#10
Tiong Y Lim, Enoka Gonsalkorala, Mary D Cannon, Stella Gabeta, Leonie Penna, Nigel D Heaton, Michael A Heneghan
BACKGROUND: Liver transplantation (LT) is a successful treatment for both acute liver failure and end-stage liver disease. The number of women of reproductive age undergoing LT is increasing. Pregnancy outcomes are favourable but there is still a lack of prognostic markers. We aimed to identify factors predictive of adverse pregnancy outcomes in LT recipients. METHODS: An analysis of all pregnancies occurring in LT recipients from 1989-2016 at King's College Hospital was performed...
March 14, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29536574/comparison-of-diagnostic-accuracy-of-early-screening-for-pre-eclampsia-by-nice-guidelines-and-a-method-combining-maternal-factors-and-biomarkers-results-of-spree
#11
M Y Tan, D Wright, A Syngelaki, R Akolekar, S Cicero, D Janga, M Singh, E Greco, A Wright, K Maclagan, L C Poon, K H Nicolaides
OBJECTIVE: To test the hypothesis that the performance of first-trimester screening for pre-eclampsia (PE) by a method that uses Bayes' theorem to combine maternal factors with biomarkers is superior to that defined by current National Institute for Health and Care Excellence (NICE) guidelines. METHODS: This was a prospective multicenter study (screening program for pre-eclampsia (SPREE)) in seven National Health Service maternity hospitals in England, of women recruited between April and December 2016...
March 14, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29523283/the-role-of-angiogenic-biomarkers-and-uterine-artery-doppler-in-pregnant-women-with-systemic-lupus-erythematosus-or-antiphospholipid-syndrome
#12
M E Rodríguez-Almaraz, I Herraiz, P I Gómez-Arriaga, P Vallejo, E Gonzalo-Gil, A Usategui, E A López-Jiménez, A Galindo, M Galindo
OBJECTIVE: To evaluate the usefulness of the uterine artery mean pulsatility index (mPI-UtA) and the sFlt-1/PlGF ratio in women with systemic lupus erythematosus (SLE) or antiphospholipid syndrome (APS) for the prediction of placental dysfunction-related adverse outcomes (AO), namely pre-eclampsia (PE) and intrauterine growth restriction (IUGR), and for differential diagnosis between PE and SLE flares. STUDY DESIGN: Observational prospective cohort study of 57 pregnant women with SLE or APS...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29523269/early-diagnosis-of-preeclampsia-using-placental-growth-factor-an-operational-pilot-study-in-maputo-mozambique
#13
Beatriz Manriquez Rocha, Francisco Mbofana, Osvaldo Loquiha, Chishamiso Mudenyanga, U Vivian Ukah, Laura A Magee, Peter von Dadelszen
In well-resourced settings, reduced circulating maternal free placental growth factor (PlGF) aids in either predicting or confirming the diagnosis of preeclampsia, fetal growth restriction, stillbirth, preterm birth, and delivery within 14 days of testing when pre-eclampsia is suspected. This operational pilot implementation of maternal plasma PlGF in women with suspected preeclampsia was conducted in six antenatal clinics in Maputo, Mozambique (six control clinics for comparison). The primary outcome was transfer to higher levels of care, following the informative PlGF assay...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29513563/chronic-hypertension-in-pregnancy-the-impact-of-ethnicity-and-superimposed-preeclampsia-on-placental-endothelial-and-renal-biomarkers
#14
Louise Mary Webster, Carolyn Gill, Paul T Seed, Kate Bramham, Cornelia Wiesender, Catherine Nelson-Piercy, Jenny E Myers, Lucy C Chappell
Black ethnicity is associated with worse pregnancy outcomes in women with chronic hypertension. Pre-existing endothelial and renal dysfunction, and poor placentation may contribute but pathophysiological mechanisms underpinning increased risk are poorly understood. This cohort study aimed to investigate the relationship between ethnicity, superimposed pre-eclampsia and longitudinal changes in markers of endothelial, renal and placental dysfunction in women with chronic hypertension. Plasma concentrations of placental growth factor (PlGF), syndecan-1, renin, aldosterone, and urinary angiotensinogen:creatinine ratio (AGTCR), protein:creatinine ratio (PCR) and albumin:creatinine ratio (ACR) were quantified during pregnancy and postpartum in women with chronic hypertension...
March 7, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29512277/re-predicting-delivery-of-a-small-for-gestational-age-infant-and-adverse-perinatal-outcome-in-women-with-suspected-pre-eclampsia-m-griffin-p-t-seed-s-duckworth-r-north-j-myers-l-mackillop-n-simpson-j-waugh-d-anumba-l-c-kenny-c-w-g-redman-a-h-shennan-and-l-c
#15
COMMENT
https://www.readbyqxmd.com/read/29498431/addition-of-nt-probnp-to-sflt-1-plgf-ratio-improves-prediction-of-pre-eclampsia-requiring-delivery-within-1-week-when-sflt-1-plgf-ratio-is-above-38-results-of-longitudinal-cohort-study
#16
Enric Sabrià Bach, Paloma Lequerica-Fernández, Paula Lafuente-Ganuza, Edwin Eguia Ángeles, Ana I Escudero, Eduardo Martínez-Morillo, Carles Barceló Vidal, Francisco V Alvárez
OBJECTIVES: Short-term prediction of pre-eclampsia using the sFlt-1/PlGF ratio is characterized by frequent false positive results. As such, no treatment can be recommended to test positive patients. Multiple measurements are common in these patients. AIM: To evaluate the influence of NT-proBNP, uric acid and the sFlt-1/PlGF ratio in the prediction of delivery with pre-eclampsia within one week in singleton pregnancies from 24 weeks 0 days to 36 weeks 6 days of gestation, with signs and symptoms of pre-eclampsia and a sFlt-1/PlGF ratio above 38...
March 2, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29482567/oxidative-stress-and-endothelial-function-in-normal-pregnancy-versus-pre-eclampsia-a-combined-longitudinal-and-case-control-study
#17
Dominique Mannaerts, Ellen Faes, Jan Gielis, Emeline Van Craenenbroeck, Paul Cos, Marc Spaanderman, Wilfried Gyselaers, Jerome Cornette, Yves Jacquemyn
BACKGROUND: Pre-eclampsia (PE) is related to an impaired endothelial function. Endothelial dysfunction accounts for altered vascular reactivity, activation of the coagulation cascade and loss of vascular integrity. Impaired endothelial function originates from production of inflammatory and cytotoxic factors by the ischemic placenta and results in systemic oxidative stress (OS) and an altered bioavailability of nitric oxide (•NO). The free radical •NO, is an endogenous endothelium-derived relaxing factor influencing endothelial function...
February 27, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29442407/prediction-and-prevention-of-pre-eclampsia-in-asian-subpopulation
#18
REVIEW
Tuangsit Wataganara, Jarunee Leetheeragul, Suchittra Pongprasobchai, Anuwat Sutantawibul, Chayawat Phatihattakorn, Surasak Angsuwathana
The benefit of the early administration of aspirin to reduce preterm pre-eclampsia among screened positive European women from multivariate algorithmic approach (ASPRE trial) has opened an intense debate on the feasibility of universal screening. This review aims to assess the new perspectives in the combined screening of pre-eclampsia in the first trimester of pregnancy and the chances for prevention using low-dose aspirin with special emphasis on the particularities of the Asian population. PubMed, CENTRAL and Embase databases were searched from inception until 15 November 2017 using combinations of the search terms: preeclampsia, Asian, prenatal screening, early prediction, ultrasonography, pregnancy, biomarker, mean arterial pressure, soluble fms-like tyrosine kinase-1, placental growth factor, pregnancy-associated plasma protein-A and pulsatility index...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29416695/association-between-hypertensive-disorders-of-pregnancy-and-risk-of-autism-in-offspring-a-systematic-review-and-meta-analysis-of-observational-studies
#19
Ruo-Ting Xu, Qing-Xian Chang, Qi-Qiong Wang, Jian Zhang, Lai-Xin Xia, Nanbert Zhong, Yan-Hong Yu, Mei Zhong, Qi-Tao Huang
Background: Autism spectrum disorder (ASD) is a common severe pervasive neurodevelopmental disorder of undetermined etiology. Environmental exposures, especially pregnancy complications, have been increasingly recognized as a potential risk factor for ASD. Our aim was to (1) systematically evaluate the association between hypertensive disorders of pregnancy (HDP) and the risk of ASD in offspring, (2) specifically draw a subgroup analysis of disease severity in patients with HDP to achieve more sufficient evidence on this issue...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29405972/combination-of-first-trimester-serum-afamin-levels-and-three-dimensional-placental-bed-vascularization-as-a-possible-screening-method-to-detect-women-at-risk-for-adverse-pregnancy-complications-like-pre-eclampsia-and-gestational-diabetes-mellitus-in-low-risk
#20
Allessandra Tramontana, Eleonore Pablik, Gerhard Stangl, Beda Hartmann, Hans Dieplinger, Erich Hafner
OBJECTIVE: Aim of the study was to assess the correlation of first trimester serum afamin levels with three-dimensional placental bed vascularization in pregnant women and its prognostic value for predicting pre-eclampsia and future fetal and maternal complications during pregnancy. METHODS: In this nested case-control study all pregnant women registered for delivery during a period of 3 years were routinely screened in the first trimester. Serum afamin levels were assessed in 764 women and correlated to 5 pregnancy outcome groups: gestational hypertension (n = 76), pre-eclampsia (n = 33), intrauterine growth restriction (n = 91), pre-term birth (n = 39), gestational diabetes mellitus (n = 170); In addition, measurements of first trimester myometrial vascularization index were performed and, in combination with afamin tested as a possible screening method to detect women at-risk for the development of adverse complications in low-risk pregnancies at the time of the first trimester...
February 2018: Placenta
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