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"Prediction" AND "pre-eclampsia"

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https://www.readbyqxmd.com/read/29345041/serum-amyloid-a-procalcitonin-highly-sensitive-c-reactive-protein-and-tumor-necrosis-factor-alpha-levels-and-acute-inflammatory-response-in-patients-with-hemolysis-elevated-liver-enzymes-low-platelet-count-hellp-and-eclampsia
#1
Kazım Uckan, Hanım Guler Sahin
AIM: The aim of this study was to determine the relationship between serum amyloid A (SAA), procalcitonin (ProC), highly sensitive C reactive protein (hsCRP) and tumor necrosis factor (TNF) alpha activity in patients with pre-eclampsia, eclampsia and hemolysis, elevated liver enzymes, low platelet count (HELLP), and the pathogenesis and severity of the disease. METHOD: Ninety patients at ≥ 32 gestational weeks, according to the last date of menstruation and ultra-sonographic measurements, diagnosed with pre-eclampsia (30 patients), eclampsia (30 patients) or HELLP syndrome (30 patients) were included in the study...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29318732/association-between-fetal-fraction-on-cell-free-dna-testing-and-first-trimester-markers-for-pre-eclampsia
#2
Daniel L Rolnik, Fabricio da Silva Costa, Timothy J Lee, Maximilian Schmid, Andrew C McLennan
AIMS: To evaluate the association of fetal fraction on cell-free DNA (cfDNA) testing with first trimester markers for pre-eclampsia and to investigate a possible association of low fetal fraction with increased risk for pre-eclampsia (PE) and fetal growth restriction (FGR). METHODS: This was a retrospective cohort study including all women with singleton pregnancies who had risk calculation for PE and FGR between 11+0 and 13+6 weeks' gestation and also decided to have cfDNA as a primary or secondary screening test for chromosomal abnormalities at any gestational age in two Fetal Medicine clinics in Sydney and Melbourne, Australia, between March 2013 and May 2017...
January 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29214752/evaluation-of-sflt-1-plgf-ratio-for-predicting-and-improving-clinical-management-of-pre-eclampsia-experience-in-a-specialized-perinatal-care-center
#3
Hélène Caillon, Cécile Tardif, Erwan Dumontet, Norbert Winer, Damien Masson
BACKGROUND: Management of pregnant women at high risk of pre-eclampsia (PE) requires frequent monitoring, with referral to specialized perinatal care centers. Reliable tests are necessary to improve prediction of PE and related complications and to assess disease severity and progression. An imbalance in two biomarkers, soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF), is involved in PE pathogenesis. The sFlt-1 to PlGF ratio is increased in pregnant women before the onset of PE...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29198742/prediction-of-adverse-maternal-outcomes-from-pre-eclampsia-and-other-hypertensive-disorders-of-pregnancy-a-systematic-review
#4
REVIEW
U Vivian Ukah, Dane A De Silva, Beth Payne, Laura A Magee, Jennifer A Hutcheon, Helen Brown, J Mark Ansermino, Tang Lee, Peter von Dadelszen
BACKGROUND: The hypertensive disorders of pregnancy are a leading cause of maternal and perinatal mortality and morbidity. The ability to predict these complications using simple tests could aid in management and improve outcomes. We aimed to systematically review studies that reported on potential predictors of adverse maternal outcomes among women with a hypertensive disorder of pregnancy. METHODS: We searched MEDLINE, Embase and CINAHL (inception - December 2016) for studies of predictors of severe maternal complications among women with a hypertensive disorder of pregnancy...
November 21, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29191735/first-trimester-serum-afamin-concentrations-are-associated-with-the-development-of-pre-eclampsia-and-gestational-diabetes-mellitus-in-pregnant-women
#5
Allessandra Tramontana, Benjamin Dieplinger, Gerhard Stangl, Erich Hafner, Hans Dieplinger
OBJECTIVE: Aim of this study was to assess the prognostic capability of afamin to predict pregnancy complications. METHOD: First-trimester screening was consecutively performed in 4948 pregnant women, of whom 474 women developed pregnancy complications [gestational hypertension (n=84), pre-eclampsia (n=30), intrauterine growth restriction (n=107), preterm birth (n=44), and gestational diabetes mellitus (n=209)]. To each woman with pregnancy complications an uncomplicated pregnancy was matched for body mass index...
January 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29175171/early-warning-system-hypertension-thresholds-to-predict-adverse-outcomes-in-pre-eclampsia-a-prospective-cohort-study
#6
Hannah L Nathan, Paul T Seed, Natasha L Hezelgrave, Annemarie De Greeff, Elodie Lawley, John Anthony, David R Hall, Wilhelm Steyn, Lucy C Chappell, Andrew H Shennan
OBJECTIVES: To evaluate the association between blood pressure (BP) measurements and adverse outcomes in women with pre-eclampsia. STUDY DESIGN: A prospective cohort study of women with pre-eclampsia admitted to three South African tertiary facilities. BP was measured using the CRADLE Vital Signs Alert (VSA), incorporated with a traffic light early warning system; green: systolic BP <140 mmHg and diastolic BP <90 mmHg, yellow: systolic BP 140-159 and/or diastolic BP 90-109 mmHg (but neither is above the upper threshold), red: systolic BP ≥160 mmHg and/or diastolic BP ≥110 mmHg...
November 21, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29175169/outcome-of-pregnancy-with-new-onset-proteinuria-and-progression-to-pre-eclampsia-a-retrospective-analysis
#7
Wai Hang Chung, William Wing Kee To
OBJECTIVE: To examine maternal and neonatal outcomes of gestational proteinuria, and to identify maternal characteristics for progression to pre-eclampsia. STUDY DESIGN: Retrospective cohort. Included all pregnant women who delivered between Jan 2014-Feb 2017 with new onset proteinuria in a single obstetric unit. Demographic, maternal and neonatal outcomes were compared. RESULTS: Eighteen (25%) out of 73 women with new onset gestational proteinuria developed pre-eclampsia...
November 21, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29162956/risk-assessment-at-11-14-week-antenatal-visit-a-tertiary-referral-center-experience-from-south-india
#8
Anusha Vellamkondu, Akhila Vasudeva, Rajeshwari G Bhat, Asha Kamath, Sapna V Amin, Lavanya Rai, Pratap Kumar
Background: Present study carried out in a tertiary referral hospital in South India attempts to determine the predictive value of integrated screening at 11-14-week antenatal visit. Objectives: To determine the detection rate of fetal abnormalities at 11-14 weeks and also to predict the placental dysfunction disorders based on early integrated evaluation. Method: Integrated screening performed on 440 women between 11 and 14 weeks, including detailed maternal history [medical history, bad obstetric history (BOH)], body mass index (BMI), mean arterial pressure (MAP), detailed ultrasound and maternal serum biochemistry as part of combined first-trimester screening for aneuploidy...
December 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29162953/evaluation-of-spot-urinary-albumin-creatinine-ratio-as-screening-tool-in-prediction-of-pre-eclampsia-in-early-pregnancy
#9
Vineet V Mishra, Preeti A Goyal, Roy Priyankur, S Choudhary, Rohina S Aggarwal, Khushali Gandhi, Bhumika Vyas, Shaheen Hokabaj
Objective: The aim of this study was to establish whether a spot urinary albumin/creatinine ratio (ACR) measured between 20 and 28 weeks of gestation can predict subsequent pre-eclampsia in asymptomatic pregnant women. Design: Prospective observational study. Subjects: The patients included sixty-two women with singleton pregnancy, normal renal function and no evident proteinuria, attending antenatal clinics between 20 and 28 weeks of gestation in a tertiary care hospital...
December 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29153673/pregnancy-complications-and-later-vascular-ultrasound-measures-a-cohort-study
#10
Emily W Harville, Markus Juonala, Jorma S A Viikari, Mika Kähönen, Olli T Raitakari
OBJECTIVES: Pregnancy complications predict or even predispose to later cardiovascular disease in the mother. We examined whether pregnancy complications are associated with post-pregnancy measures of endothelial dysfunction and arterial stiffness. STUDY DESIGN: Prospective cohort; Data for 847 women female participants in the Cardiovascular Risk in Young Finns study were linked with the national birth registry. Preterm birth (<37weeks), low birthweight (<2500g), small-for-gestational-age (weight <10th percentile for gestational age), and hypertensive disorders of pregnancy were examined as predictors of later vascular measures...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153671/longitudinal-evaluation-of-uterine-perfusion-endothelial-function-and-central-blood-flow-in-early-onset-pre-eclampsia
#11
Ludmila Barcelos Porto, Augusto Henriques Fulgêncio Brandão, Henrique Vítor Leite, Antônio Carlos Vieira Cabral
OBJECTIVES: Physiopathological mechanisms that trigger clinical manifestations in pre-eclampsia (PE) remain unclear, and management is still a challenge. The identification of tools to predict the onset of the disease and prevent its complications is of great interest in medical practice. The present study aims to evaluate uterine perfusion, endothelial function and central nervous system blood flow in pregnant women with high-risk factors for PE, for comparison of the results between the group of patients who developed early onset PE and those who remained normotensive throughout pregnancy...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29145147/up-regulation-of-mir-299-suppressed-the-invasion-and-migration-of-htr-8-svneo-trophoblast-cells-partly-via-targeting-hdac2-in-pre-eclampsia
#12
Yu Gao, Ruilian She, Qian Wang, Yan Li, Haiying Zhang
Pre-eclampsia (PE), a pregnancy-associated disorder, is a major contributor to maternal mortality and morbidity worldwide. Recently, microRNAs (miRNAs) were found to be associated with the pathogenesis of PE. The present study investigated the function of miR-299 in HTR-8/SVneo trophoblast cells and explored its underlying mechanism in the pathogenesis of PE. The miR-299 and histone deacetylase 2 (HDAC2) mRNA expression levels were determined by quantitative real-time PCR. Transwell invasion and wound healing assays were used to measure cell invasive and migratory ability...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29143991/genetic-and-non-genetic-risk-factors-for-pre-eclampsia-an-umbrella-review-of-systematic-reviews-and-meta-analyses-of-observational-studies
#13
REVIEW
Konstantinos Giannakou, Evangelos Evangelou, Stefania I Papatheodorou
OBJECTIVE: To summarize evidence from the literature on the risk factors associated with preeclampsia, assess the presence of statistical biases and identify associations with robust evidence. METHODS: We searched PubMed and ISI Web of Science from inception to October, 2016, to identify systematic reviews and meta-analyses of observational studies examining associations between genetic and non-genetic risk factors for preeclampsia. For each meta-analysis we estimated the summary effect size by random-effects and fixed-effects models, the 95% confidence interval and the 95% prediction interval...
November 16, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29143639/linking-household-surveys-and-health-facility-assessments-to-estimate-intervention-coverage-for-the-lives-saved-tool-list
#14
Mufaro Kanyangarara, Victoria B Chou
BACKGROUND: Calls have been made for improved measurement of coverage for maternal, newborn and child health interventions. Recently, methods linking household and health facility surveys have been used to improve estimation of intervention coverage. However, linking methods rely the availability of household and health facility surveys which are temporally matched. Because nationally representative health facility assessments are not yet routinely conducted in many low and middle income countries, estimates of intervention coverage based on linking methods can be produced for only a subset of countries...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29115294/placental-growth-factor-and-pre-eclampsia
#15
REVIEW
K Chau, A Hennessy, A Makris
Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth. Mechanisms by which PlGF expression is regulated continue to be investigated. Low circulating PlGF precedes the manifestation of clinical disease in pre-eclamptic pregnancies and intrauterine growth restriction. This suggests that low PlGF is a marker of abnormal placentation, but it remains uncertain whether this is a cause or consequence...
December 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29102595/interest-of-speckle-tracking-in-the-detection-of-cardiac-involvement-in-pregnant-women-with-hypertensive-disorder
#16
H Ajmi, D Abid, S Milouchi, D Louati, A Sghaier, D Choura, K Chaaben, L Abid, S Kammoun
INTRODUCTION: Pre-eclampsia is associated with many cardiovascular disorders present even in asymptomatic women. Several echocardiographic parameters are used to identify them. However, these parameters may be normal until late in the course of the disease process. Which justifies using new and more sensitive techniques. PURPOSE: We sought to test the hypothesis of subclinical cardiac involvement in such patients, based on speckle tracking, and to check its sensitivity compared to the usual methods...
October 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29092851/influence-of-disease-activity-and-medications-on-offspring-birth-weight-pre-eclampsia-and-preterm-birth-in-systemic-lupus-erythematosus-a-population-based-study
#17
Carina Götestam Skorpen, Stian Lydersen, Inge-Margrethe Gilboe, Johan Fredrik Skomsvoll, Kjell Å Salvesen, Øyvind Palm, Hege Suorza Svean Koksvik, Bente Jakobsen, Marianne Wallenius
OBJECTIVES: Exploring the associations between disease activity and medications with offspring birth weight, pre-eclampsia and preterm birth in systemic lupus erythematosus (SLE). METHODS: Data from the Medical Birth Registry of Norway (MBRN) were linked with data from RevNatus, a nationwide observational register recruiting women with inflammatory rheumatic diseases. Singleton births in women with SLE included in RevNatus 2006-2015 were cases (n=180). All other singleton births registered in MBRN during this time (n=498 849) served as population controls...
November 1, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29074629/obesity-and-gynaecological-and-obstetric-conditions-umbrella-review-of-the-literature
#18
REVIEW
Ilkka Kalliala, Georgios Markozannes, Marc J Gunter, Evangelos Paraskevaidis, Hani Gabra, Anita Mitra, Vasso Terzidou, Phillip Bennett, Pierre Martin-Hirsch, Konstantinos K Tsilidis, Maria Kyrgiou
Objective To study the strength and validity of associations between adiposity and risk of any type of obstetric or gynaecological conditions.Design An umbrella review of meta-analyses.Data sources PubMed, Cochrane database of systematic reviews, manual screening of references for systematic reviews or meta-analyses of observational and interventional studies evaluating the association between adiposity and risk of any obstetrical or gynaecological outcome.Main outcomes Meta-analyses of cohort studies on associations between indices of adiposity and obstetric and gynaecological outcomes...
October 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29074472/external-validation-study-of-first-trimester-obstetric-prediction-models-expect-study-i-research-protocol-and-population-characteristics
#19
Linda Jacqueline Elisabeth Meertens, Hubertina Cj Scheepers, Raymond G De Vries, Carmen D Dirksen, Irene Korstjens, Antonius Lm Mulder, Marianne J Nieuwenhuijze, Jan G Nijhuis, Marc Ea Spaanderman, Luc Jm Smits
BACKGROUND: A number of first-trimester prediction models addressing important obstetric outcomes have been published. However, most models have not been externally validated. External validation is essential before implementing a prediction model in clinical practice. OBJECTIVE: The objective of this paper is to describe the design of a study to externally validate existing first trimester obstetric prediction models, based upon maternal characteristics and standard measurements (eg, blood pressure), for the risk of pre-eclampsia (PE), gestational diabetes mellitus (GDM), spontaneous preterm birth (PTB), small-for-gestational-age (SGA) infants, and large-for-gestational-age (LGA) infants among Dutch pregnant women (Expect Study I)...
October 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29069989/high-first-trimester-maternal-blood-cystatin-c-levels-despite-normal-serum-creatinine-predict-pre-eclampsia-in-singleton-pregnancies
#20
Martin Risch, Mette-Triin Purde, Marc Baumann, Markus Mohaupt, Beatrice Mosimann, Harald Renz, Luigi Raio, Daniel Surbek, Lorenz Risch
Early biochemical identification of women at high risk for the development of pre-eclampsia (PE) is still unsatisfactory. Renal markers measured during the first trimester were analysed to predict later occurrence of PE. A nested case-control study was conducted within the prospective predictive markers for the diagnosis of preeclampsia study. Pregnant women were included at the end of the first trimester and followed up until birth. Controls were matched to PE cases. Renal markers [i.e. creatinine, cystatin C (CysC), β2 microglobulin (B2M), β-trace protein (BTP), glomerular filtration rate estimations (eGFR) of the aforementioned markers, uric acid (UA), urea, and serum uromodulin (sUMOD)] were compared to placental growth factor (PlGF), a marker known to predict PE later in pregnancy...
December 2017: Scandinavian Journal of Clinical and Laboratory Investigation
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