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"Prediction" AND "Preeclampsia"

Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
David G Reuter, Yuk Law, Wayne C Levy, Stephen P Seslar, R Eugene Zierler, Mark Ferguson, James Chattra, Tim McQuinn, Lenna L Liu, Mark Terry, Patricia S Coffey, Jane A Dimer, Coral Hanevold, Joseph T Flynn, F Bruder Stapleton
The morbidity and mortality associated with preeclampsia is staggering. The physiology of the Page kidney, a condition in which increased intrarenal pressure causes hypertension, appears to provide a unifying framework to explain the complex pathophysiology. Page kidney hypertension is renin-mediated acutely and ischemia-mediated chronically. Renal venous outflow obstruction also causes a Page kidney phenomenon, providing a hypothesis for the increased vulnerability of a subset of women who have what we are hypothesizing is a "renal compartment syndrome" due to inadequate ipsilateral collateral renal venous circulation consistent with well-known variation in normal venous anatomy...
September 15, 2016: Journal of the American Society of Hypertension: JASH
Tiziana Frusca, Maria-Teresa Gervasi, Davide Paolini, Matteo Dionisi, Francesca Ferre, Irene Cetin
INTRODUCTION: Preeclampsia (PE) is a pregnancy disease which represents a leading cause of maternal and perinatal mortality and morbidity. Accurate prediction of PE risk could provide an increase in health benefits and better patient management. OBJECTIVE: To estimate the economic impact of introducing Elecsys sFlt-1/PlGF ratio test, in addition to standard practice, for the prediction of PE in women with suspected preeclampsia in the Italian NHS. METHODS: A decision tree model has been developed to simulate the progression of a cohort of pregnant women from the first presentation of clinical suspicion of PE in the 2nd and 3rd trimester until delivery...
October 13, 2016: Journal of Maternal-fetal & Neonatal Medicine
Jing Wang, Xing Dong, Hong-Yan Wu, Nan Wu, Xue-Jun Zhang, Xin Wang, Li-Xin Shang
BACKGROUND: Liver X receptor alpha (LXRα) and endoglin have been postulated to play roles in trophoblast invasion and lipid metabolic disturbances. However, the relationship between LXRα and endoglin levels in serum and placenta of patients with preeclampsia remains poorly understood. The objective of this study was to identify correlations between LXRα, endoglin and preeclampsia and provide new feasible methods of clinical prediction and treatment for preeclampsia. METHODS: We enrolled 45 patients with preeclampsia (24 with moderate preeclampsia and 21 with severe preeclampsia) and 15 normal pregnant women (control group) who were admitted to the Department of Obstetrics of the General Hospital of Beijing Command between October 2012 and July 2013 in this study...
2016: PloS One
Christina M Nowik, Jessica Pudwell, Graeme N Smith
OBJECTIVE: At Kingston General Hospital, women who have pregnancy-related cardiovascular risk indicators (e.g., preeclampsia, gestational hypertension, gestational diabetes) are offered standardized six-month postpartum follow-up for cardiovascular disease risk screening and counselling. We sought to assess how patient characteristics predict attendance at follow-up. METHODS: We undertook a chart review of 650 patients who delivered between April 2011 and December 2014 and had preeclampsia, gestational hypertension, or gestational diabetes...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Clare L Whitehead, Susan P Walker, Stephen Tong
Circulating nucleic acids have revolutionized prenatal diagnosis in the last decade, allowing non-invasive screening for single gene or chromosomal defects using a single sample of maternal blood. In addition to deoxyribonucleic acids (DNA), ribonucleic acids (RNA) from the placenta are released into the maternal blood from early in pregnancy and may reflect changes in gene expression occurring within the placenta. Measuring circulating RNA may therefore provide insights into the placental transcriptome without the need for invasive testing...
October 6, 2016: Prenatal Diagnosis
Omar Abuyaman, Niels Torring, Rima Obeid, Ebba Nexo
BACKGROUND: Human placenta expresses CD320, a receptor that ensures the uptake of holo-transcobalamin (holoTC). Soluble CD320 (sCD320) is present in the circulation and its concentration increases during pregnancy. AIMS: To investigate a possible association of sCD320, holoTC and total transcobalamin (TC) with the risk of subsequent preeclampsia using serum samples from asymptomatic first trimester pregnant women. Moreover, we aimed to establish reference intervals of the aforementioned biomarkers for first trimester pregnant women who remained healthy throughout pregnancy...
October 4, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
Lijie Li, Yanmei Zheng, Ying Zhu, Jianchun Li
First-trimester screening may be a major advantage over a second-trimester approach since it opens prospects for early and more efficient interventions. The aim of the current study was to evaluate whether the measurement of maternal serum inhibin A, activin A and placental growth factor (PlGF) at three to four months gestation with the second-trimester uterine artery pulsatility index (PI) are useful in predicting preeclampsia in a group of nulliparous women. All the patients also underwent uterine artery Doppler examination to measure the PI at 22-24 weeks gestation...
October 2016: Experimental and Therapeutic Medicine
Pooneh Nikuei, Nahid Davoodian, Iman Tahamtan, Abbas Ali Keshtkar
INTRODUCTION: Pre-eclampsia (PE) is a serious condition affecting 3-5% of all pregnancies worldwide. However, underlying molecular pathogenesis of this disease has largely remained unknown. Recently, several studies have indicated the possibility role of microRNAs, especially miR-210, in the aetiology of PE. The aim of this systematic review is to assess the possible role of miR-210 as a novel biomarker for the prediction of PE. METHODS AND ANALYSIS: Using a combination of mesh terms 'preeclampsia', 'microRNA' and their equivalents, an electronic search will be performed for all observational studies (cross sectional, case-control and cohort) in PubMed, Web of Science, Scopus, Embase, Cochrane, LILACS and OvidSP MEDLINE from January 2005 to December 2015...
September 28, 2016: BMJ Open
Charline Lenaerts, Liz Bond, Robin Tuytten, Cedric Delporte, Pierre Van Antwerpen, Bertrand Blankert
INTRODUCTION: Marinobufagenin (MBG), an endogenous bufadienolide cardiac inotrope, is responsible for vasoconstriction and natriuresis [1,2]. Growing interest by its implication in volume expansion mediated hypertensive states such as essential hypertension, congestive heart failure, chronic renal failure, primary aldosterism and preeclampsia (PE). Elevated endogenous MBG levels have been described early in preeclamptic patients [2-5]. AIMS: To develop a specific and sensitive analytical MBG assay with special attention for the limit of quantification (LOQ)...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
G Gagliardi, G M Tiralongo, D Lo Presti, I Pisani, D Farsetti, B Vasapollo, G P Novelli, A Andreoli, H Valensise
INTRODUCTION: Abnormalities of cardiac output, TVR and water body distribution are connected with PE and foetal growth restriction (FGR). Targets: To identify patients at risk of PE in the first trimester through USCOM system, bioimpedance and combined screening (maternal history, biophysical and biochemical markers). We enrolled 150 healthy nulliparous women with normal BMI. RESULTS: The patients were divided into two groups: Group A (TVR <1200 dynes sec cm(-5)), Group B (TVR41200 dynes sec cm(-5))...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Sammya Bezerra Maia E Holanda Moura, Paulo Cesar Praciano, Julio Augusto Gurgel Alves, Wellington P Martins, Edward Araujo, Stefan C Kane, Fabrício da Silva Costa
OBJECTIVE: To examine whether the maternal renal interlobar vein impedance index (RIVI) as assessed by first trimester ultrasonography is able to predict the later development of hypertensive disorders of pregnancy. METHODS: Venous Doppler parameters of both maternal kidneys were studied in 214 pregnant women at 11 + 0 to 13 + 6 weeks' gestation. Subjects were classified according to the outcomes related to hypertensive disorders. Detection rates and areas under receiver operating characteristic (ROC) curves were determined for the maternal RIVI impedance as a first trimester predictor for preeclampsia (PE) and gestational hypertension (GH)...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Ying Chang, Xu Chen, Hong-Yan Cui, Xing Li, Ya-Ling Xu
The aim of the present study was to determine a predictive model for early-onset preeclampsia with fetal growth restriction (FGR) to be used at 11(+0) to 13(+6) gestational weeks, by combining the maternal serum level of pregnancy-associated plasma protein-A (PAPP-A), placental growth factor (PLGF), placental protein 13 (PP13), soluble endoglin (sEng), mean arterial pressure (MAP), and uterine artery Doppler. This was a retrospective cohort study of 4453 pregnant women. Uterine artery Doppler examination was conducted in the first trimester...
September 27, 2016: Reproductive Sciences
Katja Junus, Anna-Karin Wikström, Anders Larsson, Matts Olovsson
Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53...
October 19, 2016: Journal of Maternal-fetal & Neonatal Medicine
Gavin P Guy, Hua Z Ling, Paula Garcia, Liona C Poon, Kypros H Nicolaides
OBJECTIVE: To examine the possible effects of maternal characteristics and obstetric and medical history on maternal cardiovascular parameters at 35-37 weeks' gestation. METHODS: In 3,013 singleton pregnancies at 35-37 weeks maternal characteristics and medical history were recorded; uterine artery pulsatility index, mean arterial pressure (MAP) and maternal cardiovascular parameters were measured. Multivariable regression analysis was used to determine significant predictors of the cardiovascular parameters amongst gestational age (GA), maternal characteristics and medical history...
September 27, 2016: Ultrasound in Obstetrics & Gynecology
Ioanna Dragan, David Wright, Magdalena Fiolna, Gergo Leipold, Kypros H Nicolaides
OBJECTIVE: To compare the performance of screening of the soluble fms-like tyrosine kinase 1 (sFLT-1) to placental growth factor (PLGF) ratio >38 in the prediction of delivery with preeclampsia (PE) at <1 and at <4 weeks from assessment when the test is carried out at 31-34 versus 35-37 weeks' gestation. METHODS: This was a prospective observational study in women attending for a third-trimester ultrasound scan as part of routine pregnancy care; in the first phase of the study the visit was at 30-34 weeks' gestation and in the second phase the visit was at 35-37 weeks...
September 27, 2016: Ultrasound in Obstetrics & Gynecology
Min Yi Tan, David Wright, Lenia Koutoulas, Ranjit Akolekar, Kypros H Nicolaides
OBJECTIVE: To estimate the patient-specific risk of preeclampsia (PE) at 31-34 weeks' gestation by a combination of maternal characteristics and medical history with multiple of the median (MoM) values of serum placental growth factor (PLGF) and serum soluble fms-like tyrosine kinase-1 (sFLT-1) and compare the performance of screening to that achieved by the sFLT-1 to PLGF ratio. METHODS: This was a prospective observational study in women attending for a third-trimester ultrasound scan at 31-34 weeks as part of routine pregnancy care...
September 27, 2016: Ultrasound in Obstetrics & Gynecology
Chiara Agostinis, Tamara Stampalija, Dionne Tannetta, Claudia Loganes, Liza Vecchi Brumatti, Francesco De Seta, Claudio Celeghini, Oriano Radillo, Ian Sargent, Francesco Tedesco, Roberta Bulla
PROBLEM: We have previously found that C1q is constitutively expressed by invading trophoblast and endothelial cells of decidua and contributes to vascular and tissue remodeling. Based on these findings, we sought to determine whether there were changes in the circulating level of C1q that may be used as a diagnostic and predictive marker of preeclampsia. METHOD OF STUDY: We measured the levels of C1q, C4, and complement activation products in serum or plasma of normal pregnant women and preeclamptic patients from different cohorts...
September 26, 2016: American Journal of Reproductive Immunology: AJRI
Shagufta Yousuf, Abida Ahmad, Shazia Qadir, Sabia Gul, Showkat Hussain Tali, Feroz Shaheen, Shareefa Akhtar, Rayees Dar
OBJECTIVE: To find out whether placental laterality and abnormal uterine artery waveform and resistance index, as determined by antenatal ultrasonography and Doppler, can be used as a predictor for the development of preeclampsia. METHODS: This prospective observational cohort study was conducted from August 2013 to October 2014. Two hundred and one (201) normotensive, primigravida women with singleton pregnancies attending the antenatal clinics without any high-risk factor for development of hypertension were subjected to ultrasonography at 18-22 weeks of gestation to determine the placenta location...
October 2016: Journal of Obstetrics and Gynaecology of India
S O Sharadha, N Punithavathi, T K Renuka Devi
OBJECTIVES: To compare the Asian Indian body mass index (BMI) and waist circumference (WC) with World Health Organization (WHO) BMI and WC in the prediction of adverse maternal and perinatal outcome in overweight and obese women. MATERIALS AND METHODS: Prospective analysis of 239 women booked within 10 weeks of pregnancy and followed till delivery at our centre was performed. RESULTS: The mean age of the study group was 26.08 years, of which elderly gravida was 1...
October 2016: Journal of Obstetrics and Gynaecology of India
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