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"Prediction" AND "Preeclampsia"

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https://www.readbyqxmd.com/read/29051781/prediction-of-adverse-pregnancy-outcomes-by-extreme-values-of-first-trimester-screening-markers
#1
Marina S Gomes, Mariana Carlos-Alves, Vera Trocado, Diana Arteiro, Paula Pinheiro
BACKGROUND: To determine the association between extreme values of first trimester markers and adverse pregnancy outcomes. METHODS: A retrospective cohort study of 916 women who underwent first-trimester combined screening during 2015 was performed. Extreme values of NT, pregnancy-associated plasma protein-A (PAPP-A) and free β-hCG, and their association with adverse pregnancy outcomes were analyzed. RESULTS: Low PAPP-A (<10th percentile) was associated with an increased risk for preeclampsia (adjusted odds ratio (AOR) 4...
September 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29051520/longitudinal-assessment-of-hla-and-mic-a-antibodies-in-uneventful-pregnancies-and-pregnancies-complicated-by-preeclampsia-or-gestational-diabetes
#2
Lorenz Küssel, Harald Herkner, Markus Wahrmann, Farsad Eskandary, Konstantin Doberer, Julia Binder, Petra Pateisky, Harald Zeisler, Georg A Böhmig, Gregor Bond
The significance of antibodies directed against paternal epitopes in the context of obstetric disorders is discussed controversially. In this study anti-HLA and anti-MIC-A antibodies were analysed in sera of women with uneventful pregnancy (n = 101), preeclampsia (PE, n = 55) and gestational diabetes (GDM, n = 36) using antigen specific microbeads. While two thirds of the women with uneventful pregnancy or GDM were HLA and MIC-A antibody positive in gestational week 11 to 13 with a modest increase towards the end of pregnancy, women with PE showed an inverse kinetic: 90% were HLA antibody positive in gestational week 11 to 13 and only 10% showed HLA reactivities at the end of the pregnancy...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037482/a-low-angiogenic-index-1-plgf-svegfr-1-ratio-at-24-28-weeks-of-gestation-is-a-biomarker-to-identify-the-patient-at-risk-for-subsequent-fetal-death
#3
Tinnakorn Chaiworapongsa, Roberto Romero, Offer Erez, Adi L Tarca, Agustin Conde-Agudelo, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S Hassan, Lami Yeo, Steven J Korzeniewski
OBJECTIVE: To determine if maternal plasma concentrations of angiogenic and anti-angiogenic factors measured at 24-28 weeks of gestation can predict subsequent fetal death. METHODS: A case-cohort study was designed to include 1000 randomly selected subjects and all remaining fetal deaths (cases) from a cohort of 4006 women with a singleton pregnancy, enrolled at 6-22 weeks of gestation, in a pregnancy biomarker cohort study. The placentas of all fetal deaths were histologically examined by pathologists who used a standardized protocol and were blinded to patient outcomes...
October 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29035901/ce-preeclampsia-current-approaches-to-nursing-management
#4
Cindy M Anderson, Mandy J Schmella
A clinical review of risk factors, diagnostic criteria, and patient care. ABSTRACT: Preeclampsia, one of four hypertensive disorders of pregnancy, has traditionally been characterized as new-onset hypertension and proteinuria developing after 20 weeks' gestation. It is, however, now understood to be a complex, progressive, multisystem disorder with a highly variable presentation and a number of potentially life-threatening complications. The American College of Obstetricians and Gynecologists Task Force on Hypertension in Pregnancy has refined preeclampsia diagnostic criteria accordingly, and as the disorder's pathogenesis has been more clearly defined, new targets for screening, diagnosis, prevention, and treatment have emerged...
October 13, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/29034064/personalized-therapy-against-preeclampsia-by-replenishing-placental-protein-13-pp13-targeted-to-patients-with-impaired-pp13-molecule-or-function
#5
REVIEW
Hamutal Meiri, George Osol, Irene Cetin, Sveinbjörn Gizurarson, Berthold Huppertz
Hypertensive disorders affect about one third of all people aged 20 and above, and are treated with anti-hypertensive drugs. Preeclampsia (PE) is one form of such disorders that only develops during pregnancy. It affects ten million pregnant women globally and additionally causes fetal loss and major newborn disabilities. The syndrome's origin is multifactorial, and anti-hypertensive drugs are ineffective in treating it. Biomarkers are helpful for predict its development. Generic drugs, such as low dose aspirin, were proven effective in preventing preterm PE...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/29016509/maternal-vascular-malperfusion-and-adverse-perinatal-outcomes-in-low-risk-nulliparous-women
#6
Emily Wright, Melanie C Audette, Xiang Y Ye, Sarah Keating, Barry Hoffman, Stephen J Lye, Prakesh S Shah, John C Kingdom
OBJECTIVE: To evaluate the disease burden of placental maternal vascular malperfusion pathology in a low-risk nulliparous population and test the hypothesis that a multiparameter model in the second trimester can predict maternal vascular malperfusion with high precision. METHODS: A single-center, prospective cohort study was conducted in healthy nulliparous women. Maternal vascular malperfusion disease burden was estimated by incidence, relative risk (RR), and population-attributable risk percent...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28994563/an-update-on-the-genetics-of-pre-eclampsia
#7
Andee Agius, Roberta Sultana, Christian Camenzuli, Jean Calleja-Agius, Rena Balzan
Pre-eclampsia is a progressive multisystem disorder that is exclusive to human pregnancy and defined as new hypertension presenting after 20 weeks with significant proteinuria. It is a multifactorial condition with a strong genetic component and several genes have been linked with this disorder. The main players implicated in the pathogenesis of preeclampsia include immune maladaptation, haemodynamics, endothelial function, thrombophilic disorders, oxidative stress and lipid metabolism. All of these mechanisms encompass genetic factors that might be responsible for the pathogenic changes taking place...
October 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28994561/urine-protein-to-creatinine-ratio-a-point-of-care-for-the-diagnosis-of-preeclampsia
#8
Lior Salmon, Salvatore A Mastrolia, Batel Hamou, Renana Wilkof-Segev, Ruthy Beer-Weisel, Vered Klaitman, Limor Besser, Offer Erez
BACKGROUND: To determine the correlation between the urine protein-creatinine ratio (UPCR)and the 24h-UPET;and to identify the optimal threshold values of UPCR for the diagnosis of preeclampsia and its severe form. METHODS: This prospective cohort study included 81 hypertensive pregnant patients who had a 24h-UPET and a UPCR tests. Two groups were created using a UPCR cut-off of 23.2mg/mmol[negative UPCR(n=40);positive UPCR(n=41)]. RESULTS: 1)49 patients of were diagnosed with preeclampsia, and 23 of them had a severe disease; 2)there was a significant correlation between UPCR and 24h-UPET; 3)a cut-off PUCR value of 23...
October 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28991110/photoplethysmography-and-heart-rate-variability-for-the-diagnosis-of-preeclampsia
#9
Tammy Y Euliano, Kostas Michalopoulos, Savyasachi Singh, Anthony R Gregg, Mariem Del Rio, Terrie Vasilopoulos, Amber M Johnson, Allison Onkala, Shalom Darmanjian, Neil R Euliano, Monique Ho
BACKGROUND: The goal of this study was to determine a set of timing, shape, and statistical features available through noninvasive monitoring of maternal electrocardiogram and photoplethysmography that identifies preeclamptic patients. METHODS: Pregnant women admitted to Labor and Delivery were monitored with pulse oximetry and electrocardiogram for 30 minutes. Photoplethysmogram features and heart rate variability were extracted from each data set and applied to a sequential feature selection algorithm to discriminate women with preeclampsia with severe features, from normotensive and hypertensive controls...
October 5, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28984646/first-trimester-prediction-and-prevention-of-adverse-pregnancy-outcomes-related-to-poor-placentation
#10
Arlene DʼSilva, Rina Fyfe, Jon Hyett
PURPOSE OF REVIEW: To summarize recent research findings related to first trimester prediction and prevention of adverse pregnancy outcomes associated with poor placentation. Recent publications related to prediction and prevention of preeclampsia, intrauterine growth restriction (IUGR) and stillbirth were reviewed. RECENT FINDINGS: Researchers continue to identify markers that will help predict pregnancies that go on to develop preeclampsia through screening at 11-13 weeks...
October 3, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28982017/incidence-of-subclinical-hypothyroidism-and-hypothyroidism-in-early-pregnancy
#11
Frida Hosseini Akram, Bengt Johansson, Gunnar Möllerström, Britt-Marie Landgren, Anneli Stavreus-Evers, Lottie Skjöldebrand-Sparre
BACKGROUND: Untreated and subclinical hypothyroidism (SCH) has been associated with adverse pregnancy complications such as increased risk of miscarriage, hypertension, preeclampsia, and preterm delivery. However, in Sweden, screening for thyroid dysfunction during pregnancy is only recommended for women with a high risk of thyroid disease. Therefore, the aim of this study was to determine the incidence of clinical and SCH in women in the first trimester of pregnancy. MATERIALS AND METHODS: In this prospective study, 1298 pregnant women were divided into three groups: one unselected general screening group (n = 611), one low-risk group comprising women without risk factors for thyroid disorder (n = 511), and one high-risk group comprising women with an inheritance or suspicion of thyroid disease or undergoing treatment for thyroid disease (n = 88)...
October 5, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28978981/galectin-1-as-a-novel-risk-factor-for-both-gestational-hypertension-and-preeclampsia-specifially-its-expression-at-a-low-level-in-the-second-trimester-and-a-high-level-after-onset
#12
Chikako Hirashima, Akihide Ohkuchi, Shiho Nagayama, Hirotada Suzuki, Kayo Takahashi, Manabu Ogoyama, Hironori Takahashi, Koumei Shirasuna, Shigeki Matsubara
Our aim was to evaluate whether the serum level of galectin-1 (Gal-1) at 18-24 and 27-31 weeks of gestation is a risk factor for predicting the later occurrence of not only preeclampsia (PE) but also gestational hypertension (GH). We measured serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and Gal-1 using an enzyme-linked immunosorbent assay in 81 and 73 normal pregnant women, 22 and 16 women with a later onset of GH, and 37 and 29 women with a later onset of PE at 18-24 and 27-31 weeks, respectively...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28964834/combined-use-of-serum-gamma-glutamyl-transferase-level-and-ultrasonography-improves-prediction-of-perinatal-outcomes-associated-with-preeclamptic-pregnancy
#13
Juan Wu, Wei Zhou, Quanhua Li, Rui Yuan, Hezhou Li, Shihong Cui
INTRODUCTION: Serum gamma glutamyl transferase (GGT), produced and released mostly from the liver and bile duct, is an enzyme involved in response to oxidative stress, and has been used as a maker for prediction of cardiovascular events. Umbilical artery blood flow resistance index, e.g., the systolic/diastolic ratio (S/D ratio) as determined by ultrasound, has been used to assess the fetal intrauterine conditions. While changes of GGT and S/D ratio in preeclampsia are found to be associated with the risk for adverse perinatal outcome, the potential value of combined use of the two measurements for the prediction of adverse perinatal outcome has not been determined...
September 27, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28962698/combination-of-copeptin-placental-growth-factor-and-total-annexin-v-microparticles-for-prediction-of-preeclampsia-at-10-14-weeks-of-gestation
#14
Anshul Jadli, Kanjaksha Ghosh, Purnima Satoskar, Kaizad Damania, Vandana Bansal, Shrimati Shetty
INTRODUCTION: Preeclampsia (PE) remains to be an enigmatic puzzle for clinicians and researchers perplexing them for decades. As delivery remains only choice of treatment, early prediction of PE will offer timely therapeutic invention and hence extensive research efforts have been put in identification of biomarkers which will facilitate early prediction of PE. METHODS: Serum levels of CPP, PlGF and plasma total annexin V MPs were assessed in women who subsequently developed PE (n = 33), IUGR (n = 81) and normal pregnancy outcome (n = 112) at 10-14 weeks of gestation...
October 2017: Placenta
https://www.readbyqxmd.com/read/28927814/first-and-second-trimester-serum-sflt-1-plgf-ratio-and-subsequent-preeclampsia-a-systematic-review
#15
REVIEW
Arif M Yusuf, Alyssa Kahane, Joel G Ray
OBJECTIVE: Angiogenic biomarkers may be predictive of preeclampsia before clinical symptoms. The objective of this review was to determine the relationship between first and second trimester soluble fms-like tyrosine kinase-1/ placental growth factor (sFlt-1/PlGF) ratio and preeclampsia. METHODS: A search algorithm using appropriate medical subject headings was developed. PubMed, EMBASE, and Cochrane were searched for publications from inception to July 4, 2017...
September 15, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28914979/systemic-evaluation-of-vascular-dysfunction-by-high-resolution-sonography-in-an-n%C3%AF-nitro-l-arginine-methyl-ester-hydrochloride-induced-mouse-model-of-preeclampsia-like-symptoms
#16
Ying Zhao, Ning Yang, Hanying Li, Wei Cai, Xin Zhang, Yongqiang Ma, Xiulong Niu, Guohong Yang, Xin Zhou, Yuming Li
OBJECTIVES: The purpose of this study was to evaluate vascular function, including arterial resistance and endothelial function, by high-resolution sonography in an Nω -nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced mouse model of preeclampsia-like symptoms. METHODS: Pregnant mice were subcutaneously injected with a saline solution (control; n = 10) or l-NAME (n = 10) between the 7th and 18th days of gestation. The resistive index and pulsatility index (RI and PI, indicators of arterial resistance) of the uteroplacental, umbilical, femoral, and common carotid arteries and the flow-mediated dilatation (index of endothelial function) of the femoral artery were measured by high-frequency sonography in both groups...
September 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28912780/inflammatory-markers-for-arterial-stiffness-in-cardiovascular-diseases
#17
REVIEW
Ioana Mozos, Clemens Malainer, Jarosław Horbańczuk, Cristina Gug, Dana Stoian, Constantin Tudor Luca, Atanas G Atanasov
Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28911139/preeclampsia-downregulates-micrornas-in-fetal-endothelial-cells-roles-of-mir-29a-c-3p-in-endothelial-function
#18
Chi Zhou, Qing-Yun Zou, Hua Li, Rui-Fang Wang, Ai-Xia Liu, Ronald R Magness, Jing Zheng
Context: Preeclampsia is a leading cause of fetal and maternal morbidity and mortality during pregnancy. Although the etiology of preeclampsia is unknown, preeclampsia offspring have increased risks of developing cardiovascular disorders in adulthood, implicating that preeclampsia programs fetal vasculature in utero. Objective: We hypothesize that preeclampsia alters expression profiles of endothelial microRNAs (miRNAs) in fetal endothelial cells and disturbs the vascular endothelial growth factor A (VEGFA)- and fibroblast growth factor 2 (FGF2)-induced endothelial function...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28904069/disturbed-placental-imprinting-in-preeclampsia-leads-to-altered-expression-of-dlx5-a-human-specific-early-trophoblast-marker
#19
Julianna Zadora, Manvendra Singh, Florian Herse, Lukasz Przybyl, Nadine Haase, Michaela Golic, Hong Wa Yung, Berthold Huppertz, Judith E Cartwright, Guy S Whitley, Guro M Johnsen, Giovanni Levi, Annette Isbruch, Herbert Schulz, Friedrich C Luft, Dominik N Müller, Anne C Staff, Laurence D Hurst, Ralf Dechend, Zsuzsanna Izsvák
Background -Preeclampsia (PE) is a complex and common human-specific pregnancy syndrome associated with placental pathology. The human-specificity provides both intellectual and methodological challenges, lacking a robust model system. Given the role of imprinted genes in human placentation and the vulnerability of imprinted genes to loss of imprinting changes, there has been extensive speculation, but no robust evidence, that imprinted genes are involved in PE. Our study aims at investigating whether disturbed imprinting contributes to PE...
September 13, 2017: Circulation
https://www.readbyqxmd.com/read/28892314/-use-of-sflt-1-plgf-ratio-in-preeclampsia-a-monocentric-retrospective-analysis
#20
L Verbeurgt, F Chantraine, J De Marchin, J-M Minon, M Nisolle
Soluble Fms-like tyrosine kinase 1 (sFlt-1) is an anti-angiogenic factor released in higher amounts in preeclampsia and implicated in endothelial dysfunction. sFlt-1/PlGF ratio is used in the prediction of preeclampsia. An sFlt-1/PlGF ratio inferior to 38 predicts the short-term absence of preeclampsia. A ratio ? 85 (early-onset PE) or ? 110 (late-onset of PE) could diagnose preeclampsia. In this study, sFlt-1/PlGF ratio has been measured in 183 patients. Sixty-seven preeclampsia have been diagnosed preeclamptic at delivery...
September 2017: Revue Médicale de Liège
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