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"Prediction" AND "Preeclampsia"

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https://www.readbyqxmd.com/read/28444286/screening-for-preeclampsia-us-preventive-services-task-force-recommendation-statement
#1
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Preeclampsia affects approximately 4% of pregnancies in the United States. It is the second leading cause of maternal mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and organ failure. Adverse perinatal outcomes for the fetus and newborn include intrauterine growth restriction, low birth weight, and stillbirth. Many of the complications associated with preeclampsia lead to early induction of labor or cesarean delivery and subsequent preterm birth...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28444285/preeclampsia-screening-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#2
Jillian T Henderson, Jamie H Thompson, Brittany U Burda, Amy Cantor
Importance: Preeclampsia is a complex disease of pregnancy with sometimes serious effects on maternal and infant morbidity and mortality. It is defined by hypertension after 20 weeks' gestation and proteinuria or other evidence of multisystem involvement. Objective: To systematically review the benefits and harms of preeclampsia screening and risk assessment for the US Preventive Services Task Force. Data Sources: MEDLINE, PubMed, and Cochrane Central Register of Controlled Trials databases from 1990 through September 1, 2015...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28418339/fetal-nasal-bone-length-as-a-novel-marker-for-prediction-of-adverse-perinatal-outcomes-in-the-first-trimester-of-pregnancy
#3
Mehmet Tunç Canda, Namık Demir, Orçun Sezer
BACKGROUND: Adverse outcomes of pregnancy are a challenging health-care problem. Prediction of adverse pregnancy outcomes is important to prevent the morbidities of the foetus and the mother. AIMS: To study the clinical interest of fetal nasal bone length in predicting adverse pregnancy outcomes in the first trimester of pregnancy. STUDY DESIGN: A population-based retrospective cohort study. METHODS: Data from 868 women with first-trimester fetal nasal bone length and birth records available were enrolled...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28401605/prediction-of-delivering-a-small-for-gestational-age-infant-and-adverse-perinatal-outcome-in-women-with-suspected-pre-eclampsia
#4
Melanie Griffin, Paul T Seed, Suzy Duckworth, Robyn North, Jenny Myers, Lucy Mackillop, Nigel Simpson, Jason Waugh, Dilly Anumba, Louise C Kenny, Christopher W G Redman, Andrew H Shennan, Lucy C Chappell
OBJECTIVE: To evaluate the test performance of 47 biomarkers and ultrasound parameters to predict subsequent delivery of an SGA infant and adverse perinatal outcome in women presenting with suspected preeclampsia. METHODS: In a prospective, multicentre observational study, 47 biomarkers and ultrasound parameters were measured in 397 women presenting with suspected preterm preeclampsia, with the objective of evaluating them as predictors of subsequent delivery of an SGA infant and adverse perinatal outcome...
April 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28395283/predictive-value-of-second-trimester-biomarkers-and-maternal-features-for-adverse-pregnancy-outcomes
#5
Enav Yefet, Olga Kuzmin, Naama Schwartz, Flora Basson, Zohar Nachum
OBJECTIVE: To establish the predictive probability for placenta-associated morbidities using second-trimester α-fetoprotein (AFP), human chorionic gonadotropin (HCG), and maternal features. PATIENTS AND METHODS: A retrospective database of all singleton deliveries with available second-trimester HCG and AFP results from 2005 to 2012 was built and divided into 0, 1, or 2 elevated markers (defined as ≥2 multiples of the median [MoM]). For each group, we analyzed the risk for adverse obstetric outcome - comprising preeclampsia, placental abruption, and birth weight below the 10th percentile - and the time of delivery in those pregnancies...
April 11, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28387873/association-between-interleukin-4-polymorphisms-and-risk-of-pre-eclampsia-in-a-population-of-chinese-pregnant-women
#6
J Chen, M Zhong, Y H Yu
Preeclampsia is a common disease unique to pregnant women, and its development involves many genetics l factors. IL-4 is an important regulatory factor of the Th2 cellular immune response, and plays an important role in the induction of placental growth. In this study, we investigated the relationship between IL-4 C-590T, C+33T and G-1098T polymorphisms and risk of pre-eclampsia in a population of pregnant women. A case-control study of 196 pregnant women with pre-eclampsia and 257 healthy controls was conducted...
April 5, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28384202/plasma-cross-gestational-sphingolipidomic-analyses-reveal-potential-first-trimester-biomarkers-of-preeclampsia
#7
Aneta Dobierzewska, Sony Soman, Sebastian E Illanes, Andrew J Morris
INTRODUCTION: Preeclampsia (PE) is a gestational disorder, manifested in the second half of pregnancy by maternal hypertension, proteinuria and generalized edema. PE is a major cause of maternal and fetal morbidity and mortality, accounting for nearly 40% of all premature births worldwide. Bioactive sphingolipids are emerging as key molecules involved in etiopathogenesis of PE, characterized by maternal angiogenic imbalance and symptoms of metabolic syndrome. The aim of this study was to compare the cross-gestational profile of circulating bioactive sphingolipids in maternal plasma from preeclamptic (PE) versus normotensive control (CTL) subjects with the goal of identifying sphingolipids as candidate first trimester biomarkers of PE for early prediction of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28384118/simple-approach-based-on-maternal-characteristics-and-mean-arterial-pressure-for-the-prediction-of-preeclampsia-in-the-first-trimester-of-pregnancy
#8
Rebeca Silveira Rocha, Júlio Augusto Gurgel Alves, Sammya Bezerra Maia E Holanda Moura, Edward Araujo Júnior, Alberto Borges Peixoto, Eduardo Félix Martins Santana, Wellington P Martins, Camila Teixeira Moreira Vasconcelos, Fabricio Da Silva Costa, Mônica Oliveira Batista Oriá
AIM: To propose a simple model for predicting preeclampsia (PE) in the 1st trimester of pregnancy on the basis of maternal characteristics (MC) and mean arterial pressure (MAP). METHODS: A prospective cohort was performed to predict PE between 11 and 13+6 weeks of gestation. The MC evaluated were maternal age, skin color, parity, previous PE, smoking, family history of PE, hypertension, diabetes mellitus and body mass index (BMI). Mean arterial blood pressure (MAP) was measured at the time of the 1st trimester ultrasound...
April 6, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28380456/circulating-asymmetric-dimethylarginine-and-the-risk-of-preeclampsia-a-meta-analysis-based-on-1338-participants
#9
Jing Yuan, Xinguo Wang, Yudou Xie, Yuzhi Wang, Lei Dong, Hong Li, Tongyu Zhu
BACKGROUND: Patients with preeclampsia have higher circulating asymmetric dimethylarginine (ADMA). However, whether circulating ADMA is elevated before the diagnosis of preeclampsia has not been determined. METHODS: A meta-analysis of observational studies that reported circulating ADMA level before the onset of preeclampsia was performed. Pubmed and Embase were searched. Standardized mean differences (SMD) with 95% confidence intervals (CI) were used to estimate the differences in circulating ADMA...
March 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28350837/semaphorin-3f-expression-is-reduced-in-pregnancy-complicated-by-preeclampsia-an-observational-clinical-study
#10
Giovanni Stallone, Maria Matteo, Giuseppe Stefano Netti, Barbara Infante, Adelaide Di Lorenzo, Clelia Prattichizzo, Stefania Carlucci, Federica Trezza, Loreto Gesualdo, Pantaleo Greco, Giuseppe Grandaliano
BACKGROUND AND OBJECTIVE: Preeclampsia is a systemic disorder, affecting 2-10% of pregnancies, characterized by a deregulated pro- and anti-angiogenic balance. Semaphorin 3F is an angiogenesis inhibitor. We aimed to investigate whether semaphorin 3F expression is modulated in preeclampsia. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We performed two observational single center cohort studies between March 2013 and August 2014. In the first we enrolled 110 consecutive women, undergoing an elective cesarean section; in the second we included 150 consecutive women undergoing amniocentesis for routine clinical indications at 16-18 week of gestation...
2017: PloS One
https://www.readbyqxmd.com/read/28350823/cluster-analysis-to-estimate-the-risk-of-preeclampsia-in-the-high-risk-prediction-and-prevention-of-preeclampsia-and-intrauterine-growth-restriction-predo-study
#11
Pia M Villa, Pekka Marttinen, Jussi Gillberg, A Inkeri Lokki, Kerttu Majander, Maija-Riitta Ordén, Pekka Taipale, Anukatriina Pesonen, Katri Räikkönen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori
OBJECTIVES: Preeclampsia is divided into early-onset (delivery before 34 weeks of gestation) and late-onset (delivery at or after 34 weeks) subtypes, which may rise from different etiopathogenic backgrounds. Early-onset disease is associated with placental dysfunction. Late-onset disease develops predominantly due to metabolic disturbances, obesity, diabetes, lipid dysfunction, and inflammation, which affect endothelial function. Our aim was to use cluster analysis to investigate clinical factors predicting the onset and severity of preeclampsia in a cohort of women with known clinical risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28338787/total-and-fetal-circulating-cell-free-dna-angiogenic-and-antiangiogenic-factors-in-preeclampsia-and-hellp-syndrome
#12
Rocío Muñoz-Hernández, Pablo Medrano-Campillo, Maria L Miranda, Hada C Macher, Jose Manuel Praena-Fernández, Antonio J Vallejo-Vaz, María J Dominguez-Simeon, Rafael Moreno-Luna, Pablo Stiefel
BACKGROUND: Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by hypertension and proteinuria. The HELLP syndrome is the most severe form of PE. The aim of the present study was to determine different potential biomarkers that may help us perform an early diagnosis of the disease, assess on the severity of the disease, and/or predict maternal or fetal adverse outcomes. METHODS: We measured serum levels of total and fetal circulating cell-free DNA (cfDNA), soluble endoglin, soluble form of vascular endothelial growth factor receptor, and placental growth factor in a healthy control group of pregnant women (n = 26), patients with mild (n = 37) and severe PE (n = 25), and patients with HELLP syndrome (n = 16)...
February 25, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28328031/post-traumatic-stress-disorder-and-antepartum-complications-a-novel-risk-factor-for-gestational-diabetes-and-preeclampsia
#13
Jonathan G Shaw, Steven M Asch, Jodie G Katon, Kate A Shaw, Rachel Kimerling, Susan M Frayne, Ciaran S Phibbs
BACKGROUND: Prior work shows that Post-traumatic Stress Disorder (PTSD) predicts an increased risk of preterm birth, but the causal pathway(s) are uncertain. We evaluate the associations between PTSD and antepartum complications to explore how PTSD's pathophysiology impacts pregnancy. METHODS: This retrospective cohort analysis of all Veterans Health Administration (VA)-covered deliveries from 2000-12 used the data of VA clinical and administration. Mothers with current PTSD were identified using the ICD-9 diagnostic codes (i...
March 22, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28319175/preeclampsia-in-kidney-transplanted-women-outcomes-and-a-simple-prognostic-risk-score-system
#14
Guri Baardstu Majak, Anna Varberg Reisæter, Manuela Zucknick, Bjørg Lorentzen, Siri Vangen, Tore Henriksen, Trond Melbye Michelsen
Women pregnant following kidney transplantation are at high risk of preeclampsia. Identifying the effects of preeclampsia on pregnancy outcome and allograft function in kidney transplanted women, and predicting which women will require more targeted follow-up and possible therapeutic intervention, could improve both maternal and neonatal outcome. In this retrospective cohort study of all pregnancies following kidney transplantation in Norway between 1969 and 2013, we used medical records to identify clinical characteristics predictive of preeclampsia...
2017: PloS One
https://www.readbyqxmd.com/read/28314983/dual-cutoff-of-sflt-1-plgf-ratio-in-the-stratification-of-preeclampsia-a-systematic-review-and-meta-analysis
#15
REVIEW
Mutong Zhao, Zhiqing Zhu, Chongdong Liu, Zhenyu Zhang
PURPOSE: To systematically review the approach of using two independent sFlt-1/PlGF cutoffs that has better sensitivity (cutoff-sen) and specificity (cutoff-spe) separately for risk stratification in the detection of preeclampsia. METHODS: PubMed and Embase databases and reference lists were searched up to June 2016. Inclusion criteria were blood samples for sFlt-1/PlGF with separate cutoffs (cutoff-sen and cutoff-spe) provided. Six relevant studies were identified...
March 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28306539/three-dimensional-power-doppler-of-the-placenta-and-its-clinical-applications
#16
Kelly Yamasato, Ivica Zalud
The aim of this review is to discuss three dimensional (3D) power Doppler of the placenta and its clinical applications. There is a strong clinical need to develop noninvasive, simple and widely available methods of evaluating in vivo placental function to assess fetal wellbeing. While conventional ultrasound is a proven tool in the evaluation of fetal structural anomalies and health, its ability to assess placental function, especially prior to the onset of fetal compromise, is the subject of ongoing investigation...
March 17, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28291236/acute-fatty-liver-disease-of-pregnancy-updates-in-pathogenesis-diagnosis-and-management
#17
REVIEW
Joy Liu, Tara T Ghaziani, Jacqueline L Wolf
Acute fatty liver of pregnancy (AFLP) is an obstetric emergency characterized by maternal liver failure and may have complications for the mother and fetus, including death. This review examines recent literature on the epidemiology, pathogenesis, diagnosis, and treatment of acute fatty liver of pregnancy. Pathogenesis of this disease has been linked to defects in fatty acid metabolism during pregnancy, especially in the setting of fetal genetic defects in fatty acid oxidation. The value of screening all patients for these genetic defects remains to be determined...
March 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28287888/mir-942-decreased-before-20-weeks-gestation-in-women-with-preeclampsia-and-was-associated-with-the-pathophysiology-of-preeclampsia-in-vitro
#18
Yonggang Zhang, Guoqing Huang, Yipeng Zhang, Hongling Yang, Yan Long, Qihua Liang, Zaoxiong Zheng
OBJECTIVE: To investigate the possible relationship between miR-942 levels and the pathogenesis of preeclampsia using in vitro assays and to investigate circulating miR-942 levels in the early phase of mid-of pregnancy in women who later developed preeclampsia and in women with uncomplicated pregnancies. METHODS: Plasma samples were collected from pregnant women between 12 and 20 weeks of gestation. MiR-942 levels were determined by stem-loop real-time PCR for 26 cases who subsequently developed preeclampsia as well as for 52 controls...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28282767/pulmonary-edema-in-preeclampsia-an-indonesian-case-control-study
#19
Manggala Pasca Wardhana, Erry Gumilar Dachlan, Gustaaf Dekker
OBJECTIVE: To analyze risk factors, obstetric outcome and the need for mechanical ventilation in preeclampsia complicated by pulmonary edema. MATERIALS AND METHODS: Case-control study using medical record on preeclampsia complicated by pulmonary edema patients in East Java tertiary referral hospital over 2 years. A simple scoring system was developed to predict the need for mechanical ventilation, using logistic regression. RESULTS: 1106 cases of preeclampsia were admitted, with 62 cases (5...
March 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28282763/mirna-expression-for-early-diagnosis-of-preeclampsia-onset-hope-or-hype
#20
Antonio Simone Laganà, Salvatore Giovanni Vitale, Fabrizio Sapia, Gaetano Valenti, Francesco Corrado, Francesco Padula, Agnese Maria Chiara Rapisarda, Rosario D'Anna
PURPOSE: Preeclampsia (PE) is a multi-systemic disease characterized by hypertension, proteinuria and other typical signs that can negatively affect the development of pregnancy. The outcome of the disease is strongly linked to the possibility of early diagnosis, in order to prevent the clinical manifestations. Pathogenesis is still unknown, although abnormalities of placenta development linked to angiogenesis alterations and abnormal trophoblastic invasion seem to be involved, corroborating the epigenetic theory...
March 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
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