Taesoo Kim, Aditya L Surapaneni, Insa M Schmidt, Michael T Eadon, Sahir Kalim, Anand Srivastava, Ragnar Palsson, Isaac E Stillman, Jeffrey B Hodgin, Rajasree Menon, Edgar A Otto, Josef Coresh, Morgan E Grams, Sushrut S Waikar, Eugene P Rhee
BACKGROUND: The severity of chronic histopathologic lesions on kidney biopsy is independently associated with higher risk of progressive chronic kidney disease (CKD). Because kidney biopsies are invasive, identification of blood markers that report on underlying kidney histopathology has the potential to enhance CKD care. METHODS: We examined the association between 6592 plasma protein levels measured by aptamers and the severity of interstitial fibrosis and tubular atrophy (IFTA), glomerulosclerosis, arteriolar sclerosis, and arterial sclerosis among 434 participants of the Boston Kidney Biopsy Cohort...
April 24, 2024: Journal of the American Society of Nephrology: JASN