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https://www.readbyqxmd.com/read/29777754/hmgb1-neutralization-attenuates-hippocampal-neuronal-death-and-cognitive-impairment-in-rats-with-chronic-cerebral-hypoperfusion-via-suppressing-inflammatory-responses-and-oxidative-stress
#1
Yue Hei, Rong Chen, Xicai Yi, Qianfa Long, Dakuan Gao, Weiping Liu
High mobility group box-1 (HMGB1) acts as a proinflammatory molecule once released into the extracellular space and inhibition of HMGB1 signaling has been reported be neuroprotective in neurodegenerative diseases. Besides, chronic cerebral hypoperfusion (CCH) causes cognitive impairment in neurodegenerative diseases. Here we tested the protective role of HMGB1 inhibition using anti-HMGB1 neutralizing antibody (Ab) against CCH in rats after bilateral common carotid artery occlusion (2VO). 169 male Sprague-Dawley rats underwent 2VO or sham operation...
May 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29777747/social-environment-as-a-factor-affecting-exploration-and-learning-in-pre-juvenile-rats
#2
Klaudia Modlinska, Rafał Stryjek, Anna Chrzanowska, Wojciech Pisula
Stress associated with social isolation in early life can lead to disturbances in the emotional regulation in adult rats. However, there are no reports on the impact of isolation from the mother while providing contact with peers. Under such conditions, young individuals have the opportunity to interact with others, are able to develop social behaviour, etc. Yet, there is no stimulation and care provided by the mother. We examined the relative impact of maternal contact and sibling contact in the rarely studied pre-juvenile (3rd and 4th week post birth) period on subsequent development...
May 16, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29777366/is-ganglionated-plexus-ablation-effective-for-treating-atrial-fibrillation
#3
Michiko Watanabe, Hiroki Kohno, Yusuke Kondo, Hideki Ueda, Keiichi Ishida, Yusaku Tamura, Shinichiro Abe, Yasunori Sato, Yoshio Kobayashi, Goro Matsumiya
PURPOSE: Very few studies have investigated the efficacy of ganglionated plexus ablation during the conventional maze procedure. In this study, we sought to evaluate its additive effect in reducing recurrent atrial fibrillation after concomitant maze surgery. METHODS: A retrospective study was conducted of 79 patients who underwent Cox maze IV concomitantly with open-heart surgery with (GP group) or without (Maze group) ganglionated plexus mapping. All active ganglionated plexuses were ablated...
May 18, 2018: Surgery Today
https://www.readbyqxmd.com/read/29776417/sinomenine-exerts-anticonvulsant-profile-and-neuroprotective-activity-in-pentylenetetrazole-kindled-rats-involvement-of-inhibition-of-nlrp1-inflammasome
#4
Bo Gao, Yu Wu, Yuan-Jian Yang, Wei-Zu Li, Kun Dong, Jun Zhou, Yan-Yan Yin, Da-Ke Huang, Wen-Ning Wu
BACKGROUND: Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine (SN), a bioactive alkaloid with anti-inflammatory effect, exerts neuroprotective activity in many nervous system diseases. However, little is known about the effect of SN on epilepsy. METHODS: The chronic epilepsy model was established by pentylenetetrazole (PTZ) kindling...
May 18, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29775722/inflammatory-and-oxidative-mechanisms-potentiate-bifenthrin-induced-neurological-alterations-and-anxiety-like-behavior-in-adult-rats
#5
Brahim Gargouri, Harsharan S Bhatia, Michèle Bouchard, Bernd L Fiebich, Hamadi Fetoui
Bifenthrin (BF) is a synthetic pyrethroid pesticide widely used in several countries to manage insect pests on diverse agricultural crops. Growing evidence indicates that BF exposure is associated with an increased risk of developing neurodegenerative disorders. However, the mechanisms by which BF induces neurological and anxiety alterations in the frontal cortex and striatum are not well known. The present in vivo study was carried out to determine whether reactive oxygen species (ROS)-mediated oxidative stress (OS) and neuroinflammation are involved in such alterations...
May 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29775673/gender-dependent-contribution-of-muscarinic-receptors-in-memory-retrieval-under-sub-chronic-stress
#6
Habiba Rashid, Touqeer Ahmed
Stress induces retrograde amnesia in humans and rodents. Muscarinic antagonism under normal physiological conditions causes gender dependent impairment in episodic memory retrieval. We aimed to explore the gender dependent role of muscarinic receptors in memory retrieval under sub-chronic stress condition. Male and female mice were trained for Morris water maze test and contextual fear conditioning, followed by 3 hour restraint stress per day for five days. Stress was either given alone or in combination with a daily subcutaneous injection of scopolamine (1 mg/kg) or donepezil (1 mg/kg)...
May 15, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29775564/the-antibody-rhigm22-facilitates-hippocampal-remyelination-and-ameliorates-memory-deficits-in-the-cuprizone-mouse-model-of-demyelination
#7
Charlene Cui, Jing Wang, Ariana P Mullin, Anthony O Caggiano, Tom J Parry, Raymond W Colburn, Elias Pavlopoulos
Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the CNS. In addition to motor, sensory and visual deficits, MS is also characterized by hippocampal demyelination and memory impairment. We recently demonstrated that a recombinant human-derived monoclonal IgM antibody, which is designated rHIgM22 and currently in clinical development for people with MS, accelerates remyelination of the corpus callosum in the brains of cuprizone-treated mice. Here, we investigated the effects of rHIgM22 in the hippocampus and on hippocampal-dependent learning and memory in the same mouse model of cuprizone-induced demyelination and spontaneous remyelination...
May 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29775205/modified-device-for-fluid-percussion-injury-in-rodents
#8
Wei Ouyang, Wenhui Wu, Zhiheng Fan, Jihui Wang, Huiju Pan, Weibin Yang
Fluid percussion (FP) injury model is a popular animal model of traumatic brain injury (TBI), but still there are some issues need to be addressed. To increase the validity and reliability of this technique, we adapted the FP device using electromagnetic protractor, stainless-steel cylinder, changing pressure transducer position, and foam pads to adjust the parameters of FP pulse. Besides, the adjusted FP device is more automatic. The FP pulse is promptly measured and displayed in a graphic user interface software...
May 18, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29774754/effect-of-di-2-ethylhexyl-phthalate-on-the-neuroendocrine-regulation-of-reproduction-in-adult-male-rats-and-its-relationship-to-anxiogenic-behavior-participation-of-gabaergic-system
#9
S Carbone, O J Ponzo, N Gobetto, Y A Samaniego, R Reynoso, J A Moguilevsky, R A Cutrera
The endocrine disruptor di-(2-ethylhexyl) phthalate (DEHP) is used in a variety of consumer products made with polyvinyl chloride and also in the manufacture of medical devices. DEHP disrupts reproductive tract development in an antiandrogenic manner and also may induce neurobehavioral changes. The aim of this study was to investigate the effects of chronic postnatal exposure to DEHP (30 mg/kg body weight/day, orally from birth to day 60) on the neuroendocrine regulation of the gonadal axis and its impact on the anxiety-like behavior in adult male rats, as well as the probable participation of the GABAergic system in these effects...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29774516/periodic-variation-of-aak1-in-an-a%C3%AE-1-42-induced-mouse-model-of-alzheimer-s-disease
#10
Xue Fu, Meiling Ke, Weihua Yu, Xia Wang, Qian Xiao, Min Gu, Yang Lü
Inhibition of endocytosis in an Alzheimer's disease (AD) model has been shown to be able to prevent amyloid β (Aβ)-induced damage and to exert a beneficial effect in treating AD. Adaptor-associated kinase 1 (AAK1), which binds to the adaptor protein complex 2 (AP-2), regulates the process of clathrin-mediated endocytosis. However, how AAK1 expression varies over the course of AD is unknown. In this study, we investigated AAK1 levels in AD model mice over time. Aβ1-42 was used to establish a mouse AD model, and the Morris water maze test was used to characterize the time course of Aβ1-42 -induced cognition changes...
May 17, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29773855/the-anxiolytic-like-effects-of-ginsenoside-rg3-on-chronic-unpredictable-stress-in-rats
#11
Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Dong Shen
The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). The anxiolytic-like activities were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced by blocking the decreased time and entries in the open arms in elevated plus maze test and by reversing the increased latency to feed in novelty-suppressed feeding test. In addition, the decreased levels on progesterone, allopregnanolone, serotonin (5-HT) in the prefrontal cortex and hippocampus of chronic unpredictable stress (CUS) were blocked by GRg3 (20 and 40 mg/kg, i...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772805/ethyl-acetate-fraction-from-persimmon-diospyros-kaki-ameliorates-cerebral-neuronal-loss-and-cognitive-deficit-via-the-jnk-akt-pathway-in-tmt-induced-mice
#12
Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Su Bin Park, Seul Ki Yoo, Hye Ju Han, Chul-Woo Kim, Uk Lee, Sea-Hyun Kim, Ho Jin Heo
This study was conducted to assess the antioxidant capacity and protective effect of the ethyl acetate fraction from persimmon ( Diospyros kaki ) (EFDK) on H₂O₂-induced hippocampal HT22 cells and trimethyltin chloride (TMT)-induced Institute of Cancer Research (ICR) mice. EFDK had high antioxidant activities and neuroprotective effects in HT22 cells. EFDK ameliorated behavioral and memory deficits in Y-maze, passive avoidance and Morris water maze tests. Also, EFDK restored the antioxidant system by regulating malondialdehyde (MDA), superoxide dismutase (SOD) and reduced gluthathione (GSH), and the cholinergic system by controlling the acetylcholine (ACh) level and acetylcholinesterase (AChE) activity and expression...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772261/maternal-immune-activation-with-staphylococcal-enterotoxin-a-produces-unique-behavioral-changes-in-c57bl-6-mouse-offspring
#13
Ruthy Glass, Sara Norton, Nicholas Fox, Alexander W Kusnecov
Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models using bacterial agents such as LPS and/or viral mimics such as Poly I:C, both of which act through toll-like receptors. However, fewer studies have examined the role of direct activation of maternal T-cells during pregnancy using microbial agents...
May 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29772232/hypomyelination-and-cognitive-impairment-in-mice-lacking-cd133-prominin-1
#14
Mi-Hyun Choi, Ji Eun Na, Ye Ran Yoon, Im Joo Rhyu, Young-Gyu Ko, Ja-Hyun Baik
The CD133 antigen, also known as prominin-1, is a glycoprotein that specifically localizes to plasma membrane protrusions. The precise function of CD133 remains unknown, but it is expressed in various progenitor cells including those derived from the neural and hematopoietic system, as well as different tissues. In the adult mouse brain, CD133 is highly expressed in white matter. Here, we performed immunochemical staining and electron microscopy to demonstrate that mice lacking CD133 (CD133-/- ) exhibit decreased myelin in the corpus callosum, the largest white matter tract in the brain...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29771571/effect-of-weak-combined-static-and-extremely-low-frequency-alternating-magnetic-fields-on-spatial-memory-and-brain-amyloid-%C3%AE-in-two-animal-models-of-alzheimer-s-disease
#15
Natalia V Bobkova, Vadim V Novikov, Natalia I Medvinskaya, Irina Y Aleksandrova, Inna V Nesterova, Eugenii E Fesenko
Subchronic effect of a weak combined magnetic field (MF), produced by superimposing a constant component, 42 µT and an alternating MF of 0.08 µT, which was the sum of two frequencies of 4.38 and 4.88 Hz, was studied in olfactory bulbectomized (OBE) and transgenic Tg (APPswe, PSEN1) mice, which were used as animal models of sporadic and heritable Alzheimer's disease (AD) accordingly. Spatial memory was tested in a Morris water maze on the following day after completion of training trials with the hidden platform removed...
May 17, 2018: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/29771431/study-of-molecular-mechanisms-of-learning-and-memory-impairment-in-neonatal-rats-post-intrauterine-distress-via-the-pathway-of-tau-protein-hyperphosphorylation
#16
X-S Wang, H Huang
OBJECTIVE: To explore the reversion of the excitatory amino acid receptor antagonists against the impairment of learning-memory and the hyperphosphorylation of protein Tau induced by fetal intrauterine distress in neonatal rats. MATERIALS AND METHODS: The analysis of variance of factorial design set up two intervention factors, fetal intrauterine distress (two levels: no fetal intrauterine distress and a course of fetal intrauterine distress) and the excitatory amino acid receptor antagonists (three levels: Saline; NMDA receptor antagonist MK-801; astragalosides)...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770155/neuroprotective-effect-and-molecular-mechanism-of-6-gingerol-against-scopolamine-induced-amnesia-in-c57bl-6-mice
#17
Chang-Yul Kim, Yongtaek Seo, Chan Lee, Gyu Hwan Park, Jung-Hee Jang
We have investigated the neuroprotective and memory enhancing effect of [6]-gingerol (GIN), a pungent ingredient of ginger, using an animal model of amnesia. To determine the neuroprotective effect of GIN on cognitive dysfunction, scopolamine (SCO, 1 mg/kg, i.p.) was injected into C57BL/6 mice, and a series of behavioral tests were conducted. SCO-induced behavior changes and memory impairments, such as decreased alteration (%) in Y-maze test, increased mean escape latency in water maze test, diminished step-through latency in passive avoidance test, and shortened freezing time in fear condition test, were significantly prevented and restored by the oral administration of GIN (10 or 25 mg/kg/day)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29768967/interleukin-1-receptor-1-deletion-in-focal-and-diffuse-experimental-traumatic-brain-injury-in-mice
#18
Joon Yong Chung, Nicolas Krapp, Limin Wu, Sevda Lule, Lauren McAllister, William Edmiston Iii, Samantha Martin, Emily Levy, Tanya Songtachalert, John Sherwood, Erin Buckley, Bharat Sanders, Saef Izzy, Suzanne Hickman, Shuzhen Guo, Josephine Lok, Joseph El Khoury, Eng Lo, David Kaplan, Michael Whalen
Important differences in the biology of focal and diffuse traumatic brain injury (TBI) subtypes may result in unique pathophysiological responses to shared molecular mechanisms. Interleukin-1 (IL-1) signaling has been tested as a potential therapeutic target in preclinical models of cerebral contusion and diffuse TBI, and in a phase II clinical trial, but no published studies have examined IL-1 signaling in an impact/acceleration closed head injury (CHI) model. We hypothesized that genetic deletion of IL-1 receptor-1 (IL-1R1 KO) would be beneficial in focal (contusion) and CHI in mice...
May 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29768075/evaluating-mice-lacking-serum-carboxylesterase-as-a-behavioral-model-for-nerve-agent-intoxication
#19
Emily N Dunn, Teresa M Ferrara-Bowens, Mark E Chachich, Cary L Honnold, Cristin C Rothwell, Heidi M Hoard-Fruchey, Catherine A Lesyna, Erik A Johnson, Douglas M Cerasoli, John H McDonough, C Linn Cadieux
Mice and other rodents are typically utilized for chemical warfare nerve agent research. Rodents have large amounts of carboxylesterase in their blood, while humans do not. Carboxylesterase non-specifically binds to and detoxifies nerve agent. The presence of this natural bioscavenger makes mice and other rodents poor models for studies identifying therapeutics to treat humans exposed to nerve agents. To obviate this problem, a serum carboxylesterase knockout (Es1 KO) mouse was created. In this study, Es1 KO and wild type (WT) mice were assessed for differences in gene expression, nerve agent (soman; GD) median lethal dose (MLD) values, and behavior prior to and following nerve agent exposure...
May 16, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29767238/red-mulberry-fruit-aqueous-extract-and-silk-proteins-accelerate-acute-ethanol-metabolism-and-promote-the-anti%C3%A2-oxidant-enzyme-systems-in-rats
#20
Hye Jeong Yang, Min Jung Kim, Eun Seon Kang, Da Sol Kim, Sunmin Park
Red mulberry (Morus alba) fruit is rich in anthocyanins, and mulberry leaves are used by silk worms to make silk protein. We determined that the water and ethanol extract of mulberry fruit and silk amino acids accelerated ethanol degradation and suppressed temporal cognitive dysfunction in acute alcohol administered rats. The mechanism was explored in rats with acute oral administration of silk protein and mulberry fruit extracts. Rats were given 0.3 g of dextrin (control) and water extract (WMB) and ethanol extract of mulberry (EMB), silk protein hydrolysates (SKA), and a commercial product (positive‑control) based on body weight...
May 14, 2018: Molecular Medicine Reports
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