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https://www.readbyqxmd.com/read/28324930/rtms-enhanced-gamma-oscillation-through-strengthened-network-connection
#1
Mengmeng Dou, Xin Tian
Gamma oscillations emerge generally in working memory to aspect of higher cognitive functions, and typically with the interaction of brain network. How is gamma oscillatory activity influenced by the functional connection in the brain'a network? How can gamma oscillations be increased by neural modulation to result in potential benefits for working memory? The present study aims to investigate the intensity of gamma oscillations modulated by low frequency repetitive transcranial magnetic stimulation (rTMS), and the possible brain network mechanism of increased gamma oscillations during working memory task in rats...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324704/bxd-recombinant-inbred-strains-participate-in-social-preference-anxiety-and-depression-behaviors-along-sex-differences-in-cytokines-and-tactile-allodynia
#2
Caridad López-Granero, Alessandra Antunes Dos Santos, Beatriz Ferrer, Megan Culbreth, Sudipta Chakraborty, Angel Barrasa, Maria Gulinello, Aaron B Bowman, Michael Aschner
Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers...
March 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28316272/prenatal-noise-and-restraint-stress-interact-to-alter-exploratory-behavior-and-balance-in-juvenile-rats-and-mixed-stress-reverses-these-effects
#3
Soumeya Badache, Slim Bouslama, Oualid Brahmia, Abdel Madjid Baïri, Abdel Krim Tahraoui, Ali Ladjamaa
We aimed to investigate in adolescent rats the individual and combined effects of prenatal noise and restraint stress on balance control, exploration, locomotion and anxiety behavior. Three groups of pregnant rats were exposed to daily repeated stress from day 11 to day 19 of pregnancy: 3 min noise (Noise Stress, NS); 10 min restraint (Restraint Stress, RS); or 3 min noise followed by 10 min restraint (Mixed Stress, MS). On postnatal days (PND) 44, 45 and 46, four groups of male rats (Control, NS, RS:, MS; 16 rats each), were tested as follows: 1) Beam walking (BW), 2) Open Field (OF), and 3) Elevated plus maze (EPM)...
March 19, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28315455/7-8-dihydroxyflavone-facilitates-the-action-exercise-to-restore-plasticity-and-functionality-implications-for-early-brain-trauma-recovery
#4
Gokul Krishna, Rahul Agrawal, Yumei Zhuang, Zhe Ying, Afshin Paydar, Neil G Harris, Luiz Fernando F Royes, Fernando Gomez-Pinilla
Metabolic dysfunction accompanying traumatic brain injury (TBI) severely impairs the ability of injured neurons to comply with functional demands. This limits the success of rehabilitative strategies by compromising brain plasticity and function, and highlights the need for early interventions to promote energy homeostasis. We sought to examine whether the TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF) normalizes brain energy deficits and restablishes more normal patterns of functional connectivity, while enhancing the effects of exercise during post-TBI period...
March 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28315374/glp-1-analogue-cjc-1131-prevents-amyloid-%C3%AE-protein-induced-impirments-of-spatial-memory-and-synaptic-plasticity-in-rats
#5
Sheng-Xiao Zhang, Hong-Yan Cai, Xiao-Wen Ma, Li Yuan, Jun Zhang, Zhao-Jun Wang, Yu-Feng Li, Jin-Shun Qi
Although amyloid β protein (Aβ) has been recognized as one of the main pathological characteristics in the brain of Alzheimer's disease (AD), the effective strategies against Aβ neurotoxicity are still deficient up to now. Glucagon-like peptide 1 (GLP-1), a natural gut hormone, was found to be effective in modulating insulin signaling and neural protection, but short half-life limited its clinical application in AD treatment. CJC-1131, a newly designed GLP-1 analogue with very longer half-life, has shown good effectiveness in the treatment of type 2 diabetes mellitus (T2DM)...
March 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28315340/in-vivo-pharmacological-profile-of-s-38093-a-novel-histamine-h3-receptor-inverse-agonist
#6
Fany Panayi, Aurore Sors, Lionel Bert, Brigitte Martin, Gaelle Rollin-Jego, Rodolphe Billiras, Isabelle Carrié, Karine Albinet, Laurence Danober, Nathalie Rogez, Jean-Yves Thomas, Luigi Pira, Valérie Bertaina-Anglade, Pierre Lestage
S 38093, a novel histamine H3 receptor inverse agonist, was tested in a series of neurochemical and behavioral paradigms designed to evaluate its procognitive and arousal properties. In intracerebral microdialysis studies performed in rats, S 38093 dose-dependently increased histamine extracellular levels in the prefrontal cortex and facilitated cholinergic transmission in the prefrontal cortex and hippocampus of rats after acute and chronic administration (10mg/kg i.p.). Acute oral administration of S 38093 at 0...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28314104/ginsenoside-re-ameliorates-brain-insulin-resistance-and-cognitive-dysfunction-in-high-fat-diet-induced-c57bl-6-mice
#7
Jong Min Kim, Chang Hyeon Park, Seon Kyeong Park, Tae Wan Seung, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Dae Ok Kim, Ho Jin Heo
The ameliorating effects of ginsenoside Re (G Re) on high-fat diet (HFD)-induced insulin resistance in C57BL/6 mice were investigated to assess its physiological function. In the results of behavioral tests, G Re improved cognitive dysfunction on diabetic mice using Y-maze, passive avoidance and Morris water maze tests. G Re also significantly recovered hyperglycemia and fasting blood glucose level. In the results of serum analysis, G Re decreased triglyceride (TG), total cholesterol (TCHO), low density lipoprotein cholesterol (LDLC), glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT), and increased the ratio of high density lipoprotein cholesterol (HDLC)...
March 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28304288/changes-in-synaptic-plasticity-and-glutamate-receptors-in-type-2-diabetic-kk-ay-mice
#8
Huajing Yin, Weiping Wang, Wenwen Yu, Jiang Li, Nan Feng, Ling Wang, Xiaoliang Wang
In the present study, the progressive alteration of cognition and the mechanisms of reduction in long-term potentiation (LTP) in spontaneous obese KK-Ay type 2 diabetic mice were investigated. In the study, 3-, 5-, and 7-month-old KK-Ay mice were used. The results indicated that KK-Ay mice showed cognitive deficits in the Morris water maze test beginning at the age of 3 months. LTP was significantly impaired in KK-Ay mice during whole study period (3 to 7 months). The above deficits were reversible at an early stage (3 to 5 months old) by diet intervention...
March 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28303739/the-virtual-maze-a-behavioural-tool-for-measuring-trust
#9
Joanna Hale, Madeleine E M Payne, Kathryn M Taylor, Davide Paoletti, Antonia F De C Hamilton
Trusting another person may depend on our level of generalised trust in others, as well as perceptions of that specific person's trustworthiness. However, many studies measuring trust outcomes have not discussed generalised versus specific trust. To measure specific trust in others, we developed a novel behavioural task. Participants navigate a virtual maze and make a series of decisions about how to proceed. Before each decision, they may ask for advice from two virtual characters they have briefly interviewed earlier...
March 17, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28303373/viral-mediated-overexpression-of-the-myelin-transcription-factor-1-myt1-in-the-dentate-gyrus-attenuates-anxiety-and-ethanol-related-behaviors-in-rats
#10
Amine Bahi, Jean-Luc Dreyer
RATIONALE: Myelin Transcription Factor 1 (MyT1), a member of the Zinc Finger gene family, plays a fundamental role in the nervous system. Recent research has suggested that this transcription factor is associated with the pathophysiology of psychiatric disorders including addiction, schizophrenia, and depression. However, the role of MyT1 in anxiety- and ethanol-related behaviors is still unknown. OBJECTIVES: We evaluated the effects of lentiviral-mediated overexpression of MyT1 in the dentate gyrus (DG) on anxiety- and ethanol-related behaviors in rats...
March 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28303372/ellagic-acid-ameliorates-learning-and-memory-deficits-in-a-rat-model-of-alzheimer-s-disease-an-exploration-of-underlying-mechanisms
#11
Zahra Kiasalari, Rana Heydarifard, Mohsen Khalili, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Elham Zahedi, Ashkan Sanaierad, Mehrdad Roghani
RATIONALE: Alzheimer's disease (AD) is a neurodegenerative disorder with irreversible loss of intellectual abilities. Current therapies for AD are still insufficient. OBJECTIVE: In this study, the effect of ellagic acid on learning and memory deficits was evaluated in intrahippocampal amyloid beta (Aβ25-35)-microinjected rats and its modes of action were also explored. METHODS: AD rat model was induced by bilateral intrahippocampal microinjection of Aβ25-35 and ellagic acid was daily administered (10, 50, and 100 mg/kg), and learning, recognition memory, and spatial memory were evaluated in addition to histochemical assessment, oxidative stress, cholinesterases activity, and level of nuclear factor-kappaB (NF-κB), Toll-like receptor 4 (TLR4), and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)...
March 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28302445/agmatine-attenuates-chronic-unpredictable-mild-stress-induced-anxiety-depression-like-behaviours-and-cognitive-impairment-by-modulating-nitrergic-signalling-pathway
#12
Nitin B Gawali, Vipin D Bulani, Malvika S Gursahani, Padmini S Deshpande, Pankaj S Kothavade, Archana R Juvekar
Agmatine, a neurotransmitter/neuromodulator, has shown to exert numerous effects on the CNS. Chronic stress is a risk factor for development of depression, anxiety and deterioration of cognitive performance. Compelling evidences indicate an involvement of nitric oxide (NO) pathway in these disorders. Hence, investigation of the beneficial effects of agmatine on chronic unpredictable mild stress (CUMS)-induced depression, anxiety and cognitive performance with the involvement of nitrergic pathway was undertaken...
March 13, 2017: Brain Research
https://www.readbyqxmd.com/read/28302036/pharmacological-effects-of-turmeric-on-learning-memory-and-expression-of-muscarinic-receptor-genes-m1-m3-and-m5-in-stress-induced-mouse-model
#13
Aliya Khalid, Rabia Shakeel, Saira Justin, Ghazala Iqbal, Syed Adnan Ali Shah, Saadia Zahid, Touqeer Ahmed
Stress is involved in memory impairment by multiple mechanisms including activation of Hypothalamic-Pituitary Axis, which in turn activates release of corticosterone in blood. Cholinergic system blockade by muscarinic antagonist like scopolamine, also impairs memory. AIM: This study aimed to investigate the effect of turmeric (20mg/kg) on learning and memory and cholinergic system in a mouse model of stress along with cholinergic blockade. METHODS: Restrained stress was induced and cholinergic receptors were blocked using scopolamine in mice...
March 15, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28301189/differential-effects-of-neural-inactivation-of-the-dorsolateral-striatum-on-response-and-latent-extinction
#14
Jarid Goodman, Amanda Gabriele, Mark G Packard
The present study examined the role of the dorsolateral striatum (DLS) in extinction behavior. Male Long-Evans rats were initially trained on the straight alley maze, in which they were reinforced to traverse a straight runway and retrieve food reward at the opposite end of the maze. After initial acquisition, animals were given extinction training using 1 of 2 distinct protocols: response extinction or latent extinction. For response extinction, the animal was released from the same starting position and had the opportunity to perform the originally reinforced approach response to the goal end of the maze, which no longer contained food...
April 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28299642/cerebromicrovascular-dysfunction-predicts-cognitive-decline-and-gait-abnormalities-in-a-mouse-model-of-whole-brain-irradiation-induced-accelerated-brain-senescence
#15
Zoltan Ungvari, Stefano Tarantini, Peter Hertelendy, M Noa Valcarcel-Ares, Gabor A Fülöp, Sreemathi Logan, Tamas Kiss, Eszter Farkas, Anna Csiszar, Andriy Yabluchanskiy
Whole brain irradiation (WBI) is a mainstream therapy for patients with both identifiable brain metastases and prophylaxis for microscopic malignancies. However, it also promotes accelerated senescence in healthy tissues and leads to progressive cognitive dysfunction in up to 50% of tumor patients surviving long term after treatment, due to γ-irradiation-induced cerebromicrovascular injury. Moment-to-moment adjustment of cerebral blood flow (CBF) via neuronal activity-dependent cerebromicrovascular dilation (functional hyperemia) has a critical role in maintenance of healthy cognitive function...
February 2017: Geroscience
https://www.readbyqxmd.com/read/28296079/magel2-knockout-mice-manifest-altered-social-phenotypes-and-a-deficit-in-preference-for-social-novelty
#16
Michael D Fountain, Huifang Tao, Chun-An Chen, Jiani Yin, Christian P Schaaf
MAGEL2 is one of five protein-coding, maternally imprinted, paternally expressed genes in the Prader-Willi syndrome-critical domain on chromosome 15q11-q13. Truncating pathogenic variants of MAGEL2 cause Schaaf-Yang syndrome (OMIM #615547), a neurodevelopmental disorder related to Prader-Willi syndrome. Affected individuals manifest a spectrum of neurocognitive and behavioral phenotypes, including intellectual disability and autism spectrum disorder (ASD). Magel2 knockout mice carrying a maternally inherited, imprinted wildtype allele and a paternally inherited Magel2-lacZ knock-in allele, which abolishes endogenous Magel2 gene function, exhibit several features reminiscent of the human Prader-Willi phenotypes, including neonatal growth retardation, excessive weight gain after weaning, and increased adiposity in adulthood...
March 13, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28294340/neuroprotective-effects-of-artemisinin-against-isoflurane-induced-cognitive-impairments-and-neuronal-cell-death-involve-jnk-erk1-2-signalling-and-improved-hippocampal-histone-acetylation-in-neonatal-rats
#17
Guang Xu, Yun-Li Huang, Ping-le Li, Hai-Ming Guo, Xue-Ping Han
OBJECTIVE: This study was performed to assess the effect of artemisinin against isoflurane-induced neuronal apoptosis and cognitive impairment in neonatal rats. METHODS: Artemisinin (50, 100 or 200 mg/kg b.wt/day; oral gavage) was administered to separate groups of neonatal rats starting from postnatal day 3 (P3) to postnatal day 21 (P21). On postnatal day 7 (P7), animals were exposed to inhalation anaesthetic isoflurane (0.75%) for 6 h. KEY FINDINGS: Neuronal apoptosis following anaesthetic exposure was significantly reduced by artemisinin...
March 12, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28293263/saikosaponin-a-alleviates-symptoms-of-attention-deficit-hyperactivity-disorder-through-downregulation-of-dat-and-enhancing-bdnf-expression-in-spontaneous-hypertensive-rats
#18
Sun Jichao, Han Xinmin, Ren Xianguo, Yin Dongqi, Zhou Rongyi, Lei Shuang, You Yue, Song Yuchen, Ying Jingnan
The disturbed dopamine availability and brain-derived neurotrophic factor (BDNF) expression are due in part to be associated with attention deficit hyperactivity disorder (ADHD). In this study, we investigated the therapeutical effect of saikosaponin a (SSa) isolated from Bupleurum Chinese DC, against spontaneously hypertensive rat (SHR) model of ADHD. Methylphenidate and SSa were orally administered for 3 weeks. Activity was assessed by open-field test and Morris water maze test. Dopamine (DA) and BDNF were determined in specific brain regions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28291777/adolescent-but-not-adult-ethanol-binge-drinking-modulates-cocaine-withdrawal-symptoms-in-mice
#19
Juan Carlos Ledesma, Maria A Aguilar, Pablo Giménez-Gómez, José Miñarro, Marta Rodríguez-Arias
BACKGROUND: Ethanol (EtOH) binge drinking is an increasingly common behavior among teenagers that induces long-lasting neurobehavioral alterations in adulthood. An early history of EtOH abuse during adolescence is highly correlated with cocaine addiction in adulthood. Abstinence of cocaine abuse can cause psychiatric symptoms, such as anxiety, psychosis, depression, and cognitive impairments. This study assessed the consequences of adolescent exposure to EtOH on the behavioral alterations promoted by cocaine withdrawal in adulthood...
2017: PloS One
https://www.readbyqxmd.com/read/28289387/analyses-of-mrna-profiling-through-rna-sequencing-on-a-samp8-mouse-model-in-response-to-ginsenoside-rg1-and-rb1-treatment
#20
Shuai Zhang, Dina Zhu, Hong Li, Haijing Zhang, Chengqiang Feng, Wensheng Zhang
Ginsenoside Rg1 and Rb1 are the major ingredients in two medicines called QiShengLi (Z20027165) and QiShengJing (Z20027164) approved by China. These ingredients are believed to mitigate forgetfulness. Numerous studies have confirmed that GRg1 and GRb1 offer protection against Alzheimer's disease (AD), and our morris water maze (MWM) experiment also indicated that GRg1 and GRb1 may attenuate memory deficits in the 7-month-old SAMP8 mice; however, comprehensive understanding of their roles in AD remains limited...
2017: Frontiers in Pharmacology
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