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https://www.readbyqxmd.com/read/28944854/effect-of-hippocampal-l%C3%A2-nbp-on-bdnf-and-trkb-expression-and-neurological-function-of-vascular-dementia-rats
#1
Yujing Huang, Zhaohui Li, Guangxian Nan
The pathogenesis of vascular dementia (VD) is associated with neuronal degeneration, apoptosis or necrosis following ischemic brain injury. L‑butylphthalide (L‑NBP), has been demonstrated to exhibit potent anti‑ischemic and anti‑VD effects, however the associated specific mechanism remains to be elucidated. The present study generated a VD rat model, in which the effect of L‑NBP on neurological function and expression levels of brain‑derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) were observed...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944835/xanomeline-derivative-euk1001-attenuates-alzheimer-s-disease-pathology-in-a-triple-transgenic-mouse-model
#2
Ziyan Li, Kaili Jia, Yale Duan, Dong Wang, Zongli Zhou, Suzhen Dong
Agonists of M1 muscarinic acetylcholine receptors are promising therapeutic agents for the treatment of Alzheimer's disease (AD). An example of one of these agents is xanomeline, which has been a leading candidate, however induces various unwanted adverse effects. 3‑[3‑(3‑florophenyl‑2‑propyn‑1‑ylthio)‑1,2,5‑thiadiazol-4-yl]-1,2,5,6-tetrahydro‑1‑methylpyridine oxalate (EUK1001), a fluorinated derivative of xanomeline, has been demonstrated to attenuate AD‑like neurodegenerative pathology in presenilin‑deficient mice, which has no β‑amyloid (Aβ) pathology...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944721/early-life-sugar-consumption-has-long-term-negative-effects-on-memory-function-in-male-rats
#3
Emily E Noble, Ted M Hsu, Joanna Liang, Scott E Kanoski
OBJECTIVES: Added dietary sugars contribute substantially to the diet of children and adolescents in the USA, and recent evidence suggests that consuming sugar-sweetened beverages (SSBs) during early life has deleterious effects on hippocampal-dependent memory function. Here, we test whether the effects of early-life sugar consumption on hippocampal function persist into adulthood when access to sugar is restricted to the juvenile/adolescent phase of development. METHODS: Male rats were given ad libitum access to an 11% weight-by-volume sugar solution (made with high fructose corn syrup-55) throughout the adolescent phase of development (post-natal day (PN) 26-56)...
September 25, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28944426/experimental-evaluation-of-the-efficiency-of-lipid-module-enriched-with-docosahexaenoic-acid-and-astaxantin
#4
Yu S Sidorova, V А Sarkisyan, N A Petrov, A A Kochetkova, V K Mazo
Rats of the experimental group for 30 days received a ration in which the fat component (sunflower oil) was completely substituted with a lipid module enriched with docosahexaenoic acid and astaxanthin. Anxiety of animals in elevated plus-maze test and muscle tone in the grip strength test were evaluated before and after the experiment. Exhausting treadmill exercise was simulated after 30 days of feeding the lipid module. Modification of the lipid component of the diet (enrichment with docosahexaenoic acid and astaxanthin) reduced fatigue during exhausting physical exercise, increased muscle tone, and produced an anxiolytic effect...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28944261/delayed-matching-to-place-task-in-a-dry-maze-to-measure-spatial-working-memory-in-mice
#5
Xi Feng, Karen Krukowski, Timothy Jopson, Susanna Rosi
The delayed-matching-to-place (DMP) dry maze test is a variant of DMP water maze (Steele and Morris, 1999; Faizi et al., 2012) which measures spatial working/episodic-like learning and memory that depends on both hippocampal and cortical functions (Wang and Morris, 2010; Euston et al., 2012). Using this test we can detect normal aging related spatial working memory decline, as well as trauma induced working memory deficits. Furthermore, we recently reported that fractionated whole brain irradiation does not affect working memory in mice (Feng et al...
July 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28944180/surgical-management-of-atrial-fibrillation-at-the-time-of-septal-myectomy
#6
Eduard Quintana, James L Cox
Atrial fibrillation (AF) may appear during the natural clinical course of hypertrophic cardiomyopathy (HCM). It is regarded as a complication of HCM and is a marker of advanced disease. AF is more likely to occur in untreated, obstructive HCM. Unfortunately, this represents a turning point that puts patients at increased risk of further disability, stroke and death. The presence of obstruction is an indication to proceed with septal myectomy to improve or resolve symptoms by ameliorating diastolic dysfunction...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28943199/effects-of-the-dimeric-psd-95-inhibitor-uccb01-144-on-functional-recovery-after-fimbria-fornix-transection-in-rats
#7
Jens Bak Sommer, Anders Bach, Hana Malá, Kristian Strømgaard, Jesper Mogensen, Darryl S Pickering
Pharmacological inhibition of PSD-95 is a promising therapeutic strategy in the treatment of stroke, and positive effects of monomeric and dimeric PSD-95 inhibitors have been reported in numerous studies. However, whether therapeutic effects will generalize to other types of acute brain injury such as traumatic brain injury (TBI), which has pathophysiological mechanisms in common with stroke, is currently uncertain. We have previously found a lack of neuroprotective effects of dimeric PSD-95 inhibitors in the controlled cortical impact model of TBI in rats...
September 21, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28941995/neuropeptide-s-overcomes-short-term-memory-deficit-induced-by-sleep-restriction-by-increasing-prefrontal-cortex-activity
#8
Julien Thomasson, Frédéric Canini, Betty Poly-Thomasson, Marion Trousselard, Sylvie Granon, Frédéric Chauveau
Sleep restriction (SR) impairs short term memory (STM) that might be related to different processes. Neuropeptide S (NPS), an endogenous neuropeptide that improves short term memory, activates arousal and decreases anxiety is likely to counteract the SR-induced impairment of STM. The objective of the present study was to find common cerebral pathways in sleep restriction and NPS action in order to ultimately antagonize SR effect on memory. The STM was assessed using a spontaneous spatial alternation task in a T-maze...
September 20, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28941603/proanthocyanidin-prevents-lipopolysaccharide-induced-depressive-like-behavior-in-mice-via-neuroinflammatory-pathway
#9
Xi Jiang, Ji Liu, Qian Lin, Kaili Mao, Furong Tian, Changfeng Jing, Chongbin Wang, Lianshu Ding, Cong Pang
Recent studies have demonstrated neuroinflammation and increased cytokine levels are associated with depression. Aware of the efficacy the potential anti-inflammatory and antioxidative activity of proanthocyanidin, the present study was designed to investigate the effects of proanthocyanidin on lipopolysaccharide (LPS)-induced depressive-like behavior in mice. In depressive behavior tests, the immobility time of forced swimming test (FST) and tail suspension test (TST) was increased when mice were administrated a single dose of LPS (0...
September 20, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28941415/manganese-in-teeth-and-neurobehavior-sex-specific-windows-of-susceptibility
#10
Julia Anglen Bauer, Birgit Claus Henn, Christine Austin, Silvia Zoni, Chiara Fedrighi, Giuseppa Cagna, Donatella Placidi, Roberta F White, Qiong Yang, Brent A Coull, Donald Smith, Roberto G Lucchini, Robert O Wright, Manish Arora
BACKGROUND: Manganese (Mn) is an essential element required for growth and development, but higher body burdens have been associated with neurobehavioral decrements in children. OBJECTIVES: We examined whether prenatal or postnatal Mn measured in deciduous teeth was associated with scores on a test of visuospatial learning and memory. METHODS: Deciduous teeth were collected from 142 participants (ages 10-14years) residing near varied ferro‑manganese industry in Italy...
September 20, 2017: Environment International
https://www.readbyqxmd.com/read/28941380/using-virtual-environments-to-investigate-wayfinding-in-8-to-12-year-olds-and-adults
#11
Jamie Lingwood, Mark Blades, Emily K Farran, Yannick Courbois, Danielle Matthews
Wayfinding is the ability to learn and recall a route through an environment. Theories of wayfinding suggest that for children to learn a route successfully, they must have repeated experience of it, but in this experiment we investigated whether children could learn a route after only a single experience of the route. A total of 80 participants from the United Kingdom in four groups of 20 8-year-olds, 10-year-olds, 12-year-olds, and adults were shown a route through a 12-turn maze in a virtual environment...
September 20, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28941286/manual-function-and-performance-in-humans-gorillas-and-orangutans-during-the-same-tool-use-task
#12
Ameline Bardo, Raphaël Cornette, Antony Borel, Emmanuelle Pouydebat
OBJECTIVES: Humans are known to possess more complex manual abilities than other primates. However, the manual abilities of primates have not been fully explored, and we still do not know if the manipulative abilities we attribute to humans are unique. The aim of this study was to compare the manual function and performance developed by humans, gorillas and orangutans while performing the same experimental tool use task. MATERIALS AND METHODS: The study was conducted on 20 humans, 6 gorillas, and 7 orangutans...
September 23, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28940173/liquiritigenin-ameliorates-memory-and-cognitive-impairment-through-cholinergic-and-bdnf-pathways-in-the-mouse-hippocampus
#13
Yong-Hyun Ko, Seung-Hwan Kwon, Seok-Yong Lee, Choon-Gon Jang
Liquiritigenin (LQ), a flavonoid extracted from the radix of Glycyrrhiza, has anti-inflammatory and neuroprotective properties. In this study, we evaluated the cognitive enhancing effects of LQ on learning and memory impairments induced by scopolamine (0.5 mg/kg, i.p.), a muscarinic antagonist, using the Y-maze, passive avoidance, and novel object recognition tests. A single administration of LQ significantly improved scopolamine-induced cognitive impairments in these behavioral tests. In addition, LQ dramatically inhibited acetylcholinesterase and thiobarbituric acid reactive substance activities in the hippocampus of scopolamine-induced mice in a dose-dependent manner...
September 22, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28938207/zinc-oxide-nanoparticles-in-predicted-environmentally-relevant-concentrations-leading-to-behavioral-impairments-in-male-swiss-mice
#14
Joyce Moreira de Souza, Bruna de Oliveira Mendes, Abraão Tiago Batista Guimarães, Aline Sueli de Lima Rodrigues, Thales Quintão Chagas, Thiago Lopes Rocha, Guilherme Malafaia
Although the potential neurotoxic effects from the exposure to zinc oxide nanoparticles (ZnO NPs) on humans and on experimental models have been reported in previous studies, the effects from the exposure to environmentally relevant concentrations of them remain unclear. Thus, the aim of the present study is to investigate the effects from the exposure to environmentally relevant concentrations of ZnO NPs on the behavior of male Swiss mice. The animals were daily exposed to environmentally relevant concentrations of ZnO NPs (5...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28936164/sodium-arsenite-induced-learning-and-memory-impairment-is-associated-with-endoplasmic-reticulum-stress-mediated-apoptosis-in-rat-hippocampus
#15
Hongna Sun, Yanmei Yang, Hanwen Shao, Weiwei Sun, Muyu Gu, Hui Wang, Lixin Jiang, Lisha Qu, Dianjun Sun, Yanhui Gao
Chronic arsenic exposure has been associated to cognitive deficits. However, mechanisms remain unknown. The present study investigated the neurotoxic effects of sodium arsenite in drinking water over different dosages and time periods. Based on results from the Morris water maze (MWM) and morphological analysis, an exposure to sodium arsenite could induce neuronal damage in the hippocampus, reduce learning ability, and accelerate memory impairment. Sodium arsenite significantly increased homocysteine levels in serum and brain...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28935920/inhibition-of-pde2-reverses-beta-amyloid-induced-memory-impairment-through-regulation-of-pka-pkg-dependent-neuro-inflammatory-and-apoptotic-pathways
#16
Li Wang, Yilixiati Xiaokaiti, Gang Wang, Xiaoxiao Xu, Ling Chen, Xianfeng Huang, Li Liu, Jianchun Pan, Shuqun Hu, Zhuoyou Chen, Ying Xu
Beta amyloid peptides (Aβ) are known risk factors involved in cognitive impairment, neuroinflammatory and apoptotic processes in Alzheimer's disease (AD). Phosphodiesterase 2 (PDE2) inhibitors increase the intracellular cAMP and/or cGMP activities, which may ameliorate cognitive deficits associated with AD. However, it remains unclear whether PDE2 mediated neuroapoptotic and neuroinflammatory events, as well as cognitive performance in AD are related to cAMP/cGMP-dependent pathways. The present study investigated how the selective PDE2 inhibitor BAY60-7550 (BAY) affected Aβ-induced learning and memory impairment in two classic rodent models...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935440/effects-of-acute-restraint-and-unpredictable-chronic-mild-stress-on-brain-corticotrophin-releasing-factor-mrna-in-the-elevated-t-maze
#17
José S de Andrade, Isabel C Céspedes, Renata O Abrão, Joelcimar M da Silva, Ricardo Ceneviva, Daniel Araki Ribeiro, Jackson C Bittencourt, Milena B Viana
Corticotrophin releasing factor (CRF) modulates stress/anxiety-related responses. Previous studies showed that exposure to acute restraint and unpredictable chronic mild stress (UCMS) facilitates elevated T-maze (ETM) avoidance responses, an anxiogenic-like effect. This study verified the role of CRF in the modulation of ETM avoidance and escape reactions, in unstressed rats and in animals exposed to acute restraint or to UCMS, by quantifying CRF mRNA concentrations in stress/anxiety-related brain regions, through semiquantitative in situ hybridization...
September 18, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28934393/neurofibromatosis-type-1-alternative-splicing-is-a-key-regulator-of-ras-erk-signaling-and-learning-behaviors-in-mice
#18
Hieu T Nguyen, Melissa N Hinman, Xuan Guo, Alok Sharma, Hiroyuki Arakawa, Guangbin Luo, Hua Lou
Appropriate activation of the Ras/extracellular signal-regulated kinase (ERK) protein signaling cascade within the brain is crucial for optimal learning and memory. One key regulator of this cascade is the Nf1 Ras GTPase activating protein (RasGAP), which attenuates Ras/ERK signaling by converting active Ras is bound to guanosine triphosphate, activating Ras into inactive Ras is bound to guanosine diphosphate, inactivating Ras. A previous study using embryonic stem cells and embryonic stem cell-derived neurons indicated that Nf1 RasGAP activity is modulated by the highly regulated alternative splicing of Nf1 exon 23a...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28934273/novel-derivative-of-paeonol-paeononlsilatie-sodium-alleviates-behavioral-damage-and-hippocampal-dendritic-injury-in-alzheimer-s-disease-concurrent-with-cofilin1-phosphorylated-cofilin1-and-rac1-cdc42-alterations-in-rats
#19
Fei Han, Ting-Ting Zhuang, Jing-Jing Chen, Xiu-Ling Zhu, Ya-Fei Cai, Ya-Ping Lu
Alzheimer's disease (AD) is a typical hippocampal amnesia and the most common senile dementia. Many studies suggest that cognitive impairments are more closely correlated with synaptic loss than the burden of amyloid deposits in AD progression. To date, there is no effective treatment for this disease. Paeonol has been widely employed in traditional Chinese medicine. This compound improves learning behavior in an animal model; however, the mechanism remains unclear. In this study, Paeononlsilatie sodium (Pa), a derivative of Paeonol, attenuated D-galactose (D-gal) and AlCl3-induced behavioral damages in rats based on evaluations of the open field test (OFT), elevated plus maze test (EPMT), and Morris water maze test (MWMT)...
2017: PloS One
https://www.readbyqxmd.com/read/28934025/tamec-a-new-analogue-of-cyclomyrsinol-diterpenes-decreases-anxiety-and-depression-like-behaviors-in-a-mouse-model-of-multiple-sclerosis
#20
Abdul Majid Ayatollahi, Mostafa Haji Molla Hoseini, Syed Mustafa Ghanadian, Morteza Kosari-Nasab, Fatemeh Mami, Zeinab Yazdiniapoure, Behzad Zolfaghari, Ali-Akbar Salari
Objectives There is a significant prevalence of affective disorders including depression and anxiety in people with multiple sclerosis (MS), resulting in reduced quality of life. Since the current treatments are not generally effective, further studies are needed to find appropriate drugs to alleviate anxiety and depression symptoms in these patients. Methods The effects of a new analog of cyclomyrsinol diterpenes (TAMEC) isolated from Euphorbia sogdiana on the anxiety (open field and elevated plus maze test) and depressive-like behaviors (sucrose preference test and forced swim test) in EAE-induced C57BL/6 mice (EAE; a mouse model of MS) were investigated...
September 21, 2017: Neurological Research
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