Read by QxMD icon Read

pernicious anemia and stomach cancer

Nicola Bizzaro, Antonio Antico
Pernicious anemia (PA) is a complex disorder consisting of hematological, gastric and immunological alterations. Diagnosis of PA relies on histologically proven atrophic body gastritis, peripheral blood examination showing megaloblastic anemia with hypersegmented neutrophils, cobalamin deficiency and antibodies to intrinsic factor and to gastric parietal cells. Anti-parietal cell antibodies are found in 90% of patients with PA, but have low specificity and are seen in atrophic gastritis without megaloblastic anemia as well as in various autoimmune disorders...
April 2014: Autoimmunity Reviews
L Vannella, E Lahner, J Osborn, B Annibale
BACKGROUND: Pernicious anaemia (PA) has an increased risk for gastric cancer (GC). It is not established whether PA patients need to undergo endoscopic/histological follow-up. AIM: To provide a systematic overview of the literature on PA and the development of gastric cancer, to estimate the gastric cancer incidence-rate. METHODS: According to PRISMA, we identified studies on PA patients reporting the incidence of gastric cancer. Quality of studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale...
February 2013: Alimentary Pharmacology & Therapeutics
Bruno Annibale, Edith Lahner, Gianfranco Delle Fave
Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. Pernicious anemia is associated with atrophic body gastritis, whose diagnostic criteria are based on the histologic evidence of gastric body atrophy associated with hypochlorhydria. Serological markers suggesting the presence of oxyntic mucosa damage are increased levels of fasting gastrin and decreased levels of Pepsinogen I. Without the now obsolete Schilling's test, intrinsic factor deficiency may not be proven, and gastric intrinsic factor output after pentagastric stimulation has been proposed...
December 2011: Current Gastroenterology Reports
F Dhalla, S P da Silva, M Lucas, S Travis, H Chapel
Common variable immunodeficiency disorders (CVIDs) are the most frequent symptomatic primary immunodeficiencies in adults. They comprise a heterogeneous group of pathologies, with frequent non-infectious complications in addition to the bacterial infections that usually characterize their presentation. Complications include a high risk of malignancy, especially lymphoma and gastric cancer. Helicobacter pylori infection and pernicious anaemia are risk predictors for gastric cancer in the general population and probably in patients with CVIDs...
July 2011: Clinical and Experimental Immunology
Annelie M Landgren, Ola Landgren, Gloria Gridley, Graça M Dores, Martha S Linet, Lindsay M Morton
BACKGROUND: Autoimmunity is clearly linked with hematologic malignancies, but less is known about autoimmunity and alimentary tract cancer risk, despite the specific targeting of alimentary organs and tissues by several autoimmune diseases. The authors therefore conducted the first systematic evaluation of a broad range of specific autoimmune diseases and risk for subsequent alimentary tract cancer. METHODS: On the basis of 4,501,578 US male veterans, the authors identified 96,277 men who developed alimentary tract cancer during up to 26...
March 15, 2011: Cancer
Emiko Nakao, Atsushi Mitsunaga, Tetsuya Hamano, Miho Shirato, Izumi Shirato, Takayoshi Nishino
A 59-year-old woman was initially thought to have either type A gastritis, or autoimmune gastritis by upper-gastrointestinal-tract endoscopy and a serological examination. Furthermore, the patient was also suspected to have Hashimoto disease based on a positive antithyroid-antibody test. Rheumatoid arthritis was diagnosed 1 year later. Pernicious anemia, gastric-carcinoid and stomach cancer are the primary complications of A type gastritis. However, we hypothesized that the development of other autoimmune diseases, such as autoimmune thyroid disease, was the primary complication experienced in this case...
December 2010: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Guenter J Krejs
The incidence of gastric cancer is decreasing and lies between 10 and 15 new cases per 100,000 population per year in most Western countries. Peak age is between 60 and 80 years. While distal gastric cancers account for the overall decrease in gastric cancer, tumors in the proximal stomach (cardia and esophagogastric junction) are on the rise. Recognized risk factors for gastric cancer are infection with Helicobacter pylori, dietary factors (e.g. high intake of salt-preserved foods), smoking, pernicious anemia and a history of partial gastrectomy...
2010: Digestive Diseases
B Tepes
Gastric adenocarcinoma is the fourth most common malignancy worldwide and is globally the second leading cause of cancer-related deaths each year. Among the risk factors are genetic factors (genetic diffuse gastric cancer - E-cadherin mutation (CDH1), pro- and anti-inflammatory cytokine genes and innate immune response gene polymorphisms), environmental factors (infection with the bacterium Helicobacter pylori (H. pylori), Epstein-Barr virus, nutrition: nitroso compounds, salt and antioxidants intake) and other factors (pernicious anemia, gastric polyps, gastric surgery, reproductive hormones, smoking)...
December 2009: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
No abstract text is available yet for this article.
October 1946: Acta Gastro-enterologica Belgica
I P Häkkinen
Sulphopolysaccharides, isolated from gastric juice of patients with pernicious anemia or gastric cancer, have been characterized immunologically using corresponding rabbit immunosera. Gastric juice sulphopolysaccharides differ from their normal form in the following conditions: a) when there is intestinal type metaplastic tissue in the gastric epithelium; b) in the presence of gastric cancer. Efforts to differentiate between these types by the absorption technique using rabbit immunosera were successful, and it was possible to demonstrate an antigenic determinant in sulphopolysaccharides from cancerous gastric juice not present in controls with benign intestinal type heterotopia as in pernicious anemia...
1967: Scandinavian Journal of Gastroenterology
Jeffrey Copps, Richard F Murphy, Sándor Lovas
The gastrointestinal peptide hormone gastrin is responsible for initiating the release of gastric acid in the stomach in response to the presence of food and/or humoral factors such as gastrin releasing peptide. However, it has a role in the growth and maintenance of the gastric epithelium, and has been implicated in the formation and growth of gastric cancers. Hypergastrinemia resulting from atrophic gastritis and pernicious anemia leads to hyperplasia and carcinoid formation in rats, and contributes to tumor formation in humans...
2009: Protein and Peptide Letters
A Neesse, P Michl, P Barth, M Vieth, P Langer, V Ellenrieder, T M Gress
Autoimmune atrophic gastritis (AMAG) is characterised by the presence of parietal cell antibodies (PCA) and occurs in the gastric corpus. Pernicious anaemia (PA) is regarded as the most distinct feature and sequela of AMAG and is associated with the presence of PCA in about 60 - 90 % of cases. AMAG is considered as an independent risk factor for the development of gastric cancer. Interestingly, the risk to progress from metaplasia to neoplasia and ultimately invasive cancer has exclusively been described in patients with PA...
February 2009: Zeitschrift Für Gastroenterologie
Hala El-Zimaity
PURPOSE OF REVIEW: The majority of problems in interpreting gastritis remain Helicobacter related, but their nature has changed. The present review covers gastritis historically through cancer risk staging systems. RECENT FINDINGS: Key points to remember are: Helicobacter is associated with several forms of gastritis; in the present review, I am focusing on the two ends of the disease, 'Helicobacter pylori infection', that starts with antral predominant gastritis but can continue to oxyntic predominant disease with atrophy; the role Helicobacter pylori plays in autoimmune gastritis with pernicious anemia remains unresolved; gastritis staging systems for cancer risk, namely Baylor and Operative Link on Gastritis Assessment, are currently available...
November 2008: Current Opinion in Gastroenterology
Lana Macukanović-Golubović, Vuka Katić, Gorana Rancić, Mladen Milenović, Goran Marjanović, Zoran Golubović
BACKGROUND/AIM: Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA), as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like (ECL) carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A-gastritis associated with PA. METHODS: During the period from 2000-2006, 65 patients with PA and 30 patients of the control group were examined...
August 2007: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
J A Roberts
Two corrections should be made in the item "Blood groups and disease" [Science 124, 674 (12 Oct. 1956)] which reports a paper on associations between blood groups and disease read to the British Association for the Advancement of Science. The three diseases for which the evidence is overwhelming are (i) duodenal ulcer, (ii) gastric ulcer, (iii) cancer of the stomach. As is stated, the ulcers are commoner in persons of group O, and cancer of the stomach in persons of group A. There is fairly strong evidence in connection with diabetes mellitus and pernicious anemia; but the incidence is raised in group A, not groups O and B...
December 7, 1956: Science
Ayako Hirata, Nobuatsu Nomoto, Shingo Konno, Hiroshi Nakazora, Hideki Sugimoto, Hiroshi Nemoto, Teruyuki Kurihara, Nobuo Wakata
We report a rare case of subacute combined degeneration of the spinal cord concomitant with gastric cancer. A 67-year-old man was admitted because of posterior column symptoms, pyramidal tract sign and peripheral neuropathy with severe hyperchromic anemia. He was treated with mecobalamin 1 mg IM, after which his anemia and neurological signs recovered. He was diagnosed as having subacute combined degeneration with pernicious anemia. Subsequent stomach biopsy revealed gastric cancer, and the patient underwent gastrectomy...
2006: Internal Medicine
Sandra Sipetić, Sladana Tomić-Kundaković, Hristina Vlajinac, Natasa Maksimović, Anita Knezević, Darija Kisić
INTRODUCTION: Gastric cancer was the third most common cancer worldwide in 2000, accounting for approximately 876 000 new cases or 9% of the global cancer burden. EPIDEMIOLOGICAL CHARACTERISTICS: As a result of changes in diet, the incidence of gastric cancer has decreased in most countries. Nowdays, consumption of fresh vegetables and fruits is increasing in regard to canned food. In addition to unhealthy diet, the main risk factors for gastric cancer are H. pylori infection, alcohol consumption, smoking, gastritis, stomach ulcer, gastrectomy, stomach polyposis, positive family history for gastric cancer, pernicious anemia and blood type A...
May 2005: Medicinski Pregled
No abstract text is available yet for this article.
July 13, 1950: Ugeskrift for Laeger
No abstract text is available yet for this article.
December 23, 1951: Lyon Médical
No abstract text is available yet for this article.
December 1950: Archives des Maladies de L'appareil Digestif et des Maladies de la Nutrition
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"