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Left Atrial Appendage

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https://www.readbyqxmd.com/read/29770366/complete-resolution-of-left-atrial-appendage-thrombosis-with-oral-dabigatran-etexilate-in-a-patient-with-myotonic-dystrophy-type-1-and-atrial-fibrillation
#1
Anna Rago, Andrea Antonio Papa, Giulia Arena, Marco Mosella, Antonio Cassese, Alberto Palladino, Paolo Golino
Myotonic Dystrophy type 1 (DM1) is the most common muscular dystrophy in adult life characterized by muscle dysfunction and cardiac conduction abnormalities. Atrial fibrillation frequently occurs in DM1 patients. It's related to the discontinuous and inhomogeneous propagation of sinus impulses and to the prolongation of atrial conduction time, caused by progressive fibrosis and fatty replacement of the myocardium. AF predisposes to a hyper-coagulable state and to an increased risk of thromboembolism. We report the first case of complete resolution of left atrial appendage thrombosis with oral dabigatran etexilate in a myotonic dystrophy type I patient with atrial fibrillation scheduled for transesophageal echocardiogram-guided direct current cardioversion...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29760285/occurrence-of-incomplete-endothelialization-causing-residual-permeability-after-left-atrial-appendage-closure
#2
Mathieu Granier, Guillaume Laugaudin, François Massin, Stephane Cade, Pierre François Winum, Cornelia Freitag, Jean-Luc Pasquie
AIMS: Percutaneous left atrial appendage (LAA) occlusion is occasionally incomplete, with residual permeability of the LAA on cardiac computed tomography. The cause for this is unclear. Our objective was to determine if residual permeability was related to incomplete endothelialization. METHODS: A total of 35 consecutive patients contraindicated for anticoagulant therapy admitted for LAA occlusion were included; 12 patients received a Watchman device (Boston Scientific) and 23 patients received an Amplatzer Cardiac Plug (St...
May 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29759784/atrial-tachycardias-after-surgical-atrial-fibrillation-ablation-clinical-characteristics-electrophysiological-mechanisms-and-ablation-outcomes-from-a-large-multicenter-study
#3
Rakesh Gopinathannair, Philip L Mar, Muhammad Rizwan Afzal, Luigi Di Biase, Yixi Tu, Thanmay Lakkireddy, Jaimin R Trivedi, Mark S Slaughter, Andrea Natale, Dhanunjaya Lakkireddy
OBJECTIVES: The clinical characteristics, electrophysiological mechanisms, and ablation outcomes of post-surgical atrial fibrillation ablation (SAFA) atrial tachycardias (ATs) have not been studied in a large, multicenter cohort. BACKGROUND: ATs are often seen following SAFA. METHODS: Analysis was performed on 137 patients (age, 62 ± 10 years; 74% male) who underwent catheter ablation for symptomatic post-SAFA AT from 2004 to 2013 at 3 high-volume institutions in the United States...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759706/the-human-left-atrial-venous-circulation-as-a-vascular-route-for-atrial-pharmacological-therapies-effects-of-ethanol-infusion
#4
Miguel Valderrábano, Percy Francisco Morales, Moisés Rodríguez-Mañero, Candela Lloves, Paul A Schurmann, Amish S Dave
OBJECTIVES: This study catalogued the human venous left atrium (LA) circulation system and the ablative effects of ethanol in different branches. BACKGROUND: Vascular routes to target the LA could have significant therapeutic potential. Beyond the vein of Marshall (VOM), the fluoroscopic LA venous anatomy has not been described. METHODS: Patients undergoing ethanol infusion in the VOM as adjunctive therapy to atrial fibrillation (AF) catheter ablation were included in this study...
September 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759679/left-atrial-thrombus-after-left-atrial-appendage-ligation-with-the-lariat-device
#5
Saroj Neupane, Zain Azzo, Sushruth Edla, Gerald I Cohen
No abstract text is available yet for this article.
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759670/systemic-octreotide-therapy-in-prevention-of-gastrointestinal-bleeds-related-to-arteriovenous-malformations-and-obscure-etiology-in-atrial-fibrillation
#6
Venkat Vuddanda, Mohammad-Ali Jazayeri, Mohit K Turagam, Madhav Lavu, Valay Parikh, Donita Atkins, Sudharani Bommana, Madhu Reddy Yeruva, Luigi Di Biase, Jie Cheng, Vijay Swarup, Rakesh Gopinathannair, Mojtaba Olyaee, Vijay Ivaturi, Andrea Natale, Dhanunjaya Lakkireddy
OBJECTIVES: The present study describes the use of octreotide (OCT) in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC) who have gastrointestinal (GI) bleeding related to arteriovenous malformations (AVMs), as well as its effect on OAC tolerance and subsequent rebleeding. BACKGROUND: AVMs cause significant GI bleeding, especially in patients with AF who are receiving OAC for stroke prevention. OCT has been shown to minimize recurrent GI bleeds related to AVMs...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759668/incidence-characteristics-and-clinical-course-of-device-related-thrombus-after-watchman-left-atrial-appendage-occlusion-device-implantation-in-atrial-fibrillation-patients
#7
Shunsuke Kubo, Yukiko Mizutani, Krissada Meemook, Yoshifumi Nakajima, Asma Hussaini, Saibal Kar
OBJECTIVES: This study investigated characteristics and clinical impact of device-related thrombus formation after Watchman device implantation in atrial fibrillation (AF) patients. BACKGROUND: Left atrial appendage occlusion using the Watchman device is an effective alternative to anticoagulation for stroke prevention in AF patients. However, device-related thrombus formation remains an important concern after Watchman implantation. METHODS: From 2006 to 2014, 119 consecutive AF patients underwent Watchman implantation...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759665/thoracoscopic-left-atrial-appendage-occlusion-we-can-do-it-now-should-we
#8
EDITORIAL
Richard Whitlock, Sarah MacIsaac, Stuart Connolly
No abstract text is available yet for this article.
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759664/angiographic-efficacy-of-the-atriclip-left-atrial-appendage-exclusion-device-placed-by-minimally-invasive-thoracoscopic-approach
#9
Christopher R Ellis, Sam G Aznaurov, Neel J Patel, Jennifer R Williams, Kim Lori Sandler, Steven J Hoff, Stephen K Ball, S Patrick Whalen, John Jeffrey Carr
OBJECTIVES: This study sought to assess long-term left atrial appendage (LAA) closure efficacy of the Atriclip applied via totally thoracoscopic (TT) approach with computed tomographic angiography. BACKGROUND: LAA closure is associated with a low risk for atrial fibrillation-related embolic stroke. The Atriclip exclusion device allows epicardial LAA closure, avoiding the need for post-operative oral anticoagulation. Previous data with Atriclip during open chest procedures show a high efficacy rate of closure >95%...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759616/spatial-relationships-of-complex-fractionated-atrial-electrograms-and-continuous-electrical-activity-to-focal-electrical-sources-implications-for-substrate-ablation-in-human-atrial-fibrillation
#10
Simon Kochhäuser, Atul Verma, Rupin Dalvi, Adrian Suszko, Pouria Alipour, Prashanthan Sanders, Jean Champagne, Laurent Macle, Girish M Nair, Hugh Calkins, David J Wilber, Vijay S Chauhan
OBJECTIVES: This study sought to evaluate the spatial relationships of focal electrical sources (FSs) to complex fractionated atrial electrograms (CFAE) and continuous electrical activity (CEA). BACKGROUND: Fractionated atrial electrograms have been associated with atrial fibrillation (AF) drivers in computational studies and represent ablation targets in the management of persistent AF. METHODS: We included a subset of 66 patients (age: 63 [56, 67] years, 69% persistent AF) with electroanatomic data from the SELECT AF (Selective complex fractionated atrial electrograms targeting for atrial fibrillation) randomized control trial that compared the efficacy of CFAE with CEA ablation in AF patients undergoing pulmonary vein antral ablation...
November 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759547/extensive-endothelialization-or-thrombus-related-to-new-generation-left-atrial-appendage-occluders
#11
Erwan Salaun, Jean-Claude Deharo, Gilbert Habib, Frederic Franceschi
No abstract text is available yet for this article.
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29755939/an-original-management-of-focal-atrial-tachycardia-originating-from-a-giant-left-atrial-appendage
#12
Stéphane Combes, Jean Paul Albenque, Nicolas Combes, Serge Boveda, Christelle Cardin, Vlad Ciobotaru, Issam Abouliatim
No abstract text is available yet for this article.
April 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29754931/percutaneous-left-atrial-appendage-closure-with-complex-anatomy-by-using-the-staged-kissing-watchman-technology-with-double-devices
#13
Lisheng Jiang, Erich Duenninger, Manuela Muenzel, Xin Xue, Adam Fazakas, Thorsten Keil, Jiangtao Yu
BACKGROUND: Left atrial appendage closure (LAAC) is an efficient alternative of oral anticoagulation to prevent stroke in patients with non-valvular atrial fibrillation (NVAF). Due to complexities of LAA anatomy, a complete closure may not always be obtained with a single device. The aim of this study was to evaluate the feasibility and safety of the staged 'kissing-Watchman' technology to occlude the LAA with complex anatomy. METHODS: In our center, among 300 cases underwent LAAC with Watchman device from February 2012 to December 2016, 7 complex LAAs were implanted double devices using the staged 'kissing-Watchman' technology...
May 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754808/long-term-event-reduction-after-left-atrial-appendage-closure-results-of-the-iberian-registry-ii
#14
José R López-Mínguez, Juan M Nogales-Asensio, Eduardo Infante De Oliveira, Vasco De Gama Ribeiro, Rafael Ruiz-Salmerón, Dabit Arzamendi-Aizpurua, Marco Costa, Hipólito Gutiérrez-García, José Antonio Fernández-Díaz, Victoria Martín-Yuste, Juan Carlos Rama-Merchán, Raúl Moreno-Gómez, Amparo Benedicto-Buendía, Andrés Íñiguez-Romo
INTRODUCTION AND OBJECTIVES: Many patients with nonvalvular atrial fibrillation are still left without protection due to a contraindication for anticoagulants. This study aimed to establish the occurrence of stroke and major bleeding events in patients with nonvalvular atrial fibrillation and left atrial appendage closure with long-term follow-up and to explore the factors associated with higher long-term mortality. METHODS: Analysis of a multicenter single cohort prospectively recruited from 2009 to 2015...
May 10, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29752916/giant-left-atrial-appendage-aneurysm-a-rare-entity
#15
Rajlakshmi Das, Lalit Kapoor, Somnath Ganguly, Arupratan Maity, Saibal RoyChowdhury, Pradeep Narayan
No abstract text is available yet for this article.
May 9, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29752398/device-related-thrombus-after-left-atrial-appendage-closure-incidence-predictors-and-outcomes
#16
Srinivas R Dukkipati, Saibal Kar, David R Holmes, Shephal K Doshi, Vijendra Swarup, Douglas N Gibson, Brijeshwar Maini, Nicole T Gordon, Michael L Main, Vivek Y Reddy
Background -In patients with atrial fibrillation (AF), left atrial appendage closure (LAAC) with the Watchman device prevents thromboembolism from the LAA; however, thrombus may form on the left atrial face of the device, and then potentially embolize. Herein, we studied the incidence, predictors and clinical outcome of device-related thrombus (DRT) using a large series of clinical trial cohorts of patients undergoing Watchman implantation. Methods -We studied the device arms of 4 prospective FDA trials: PROTECT-AF (n=463); PREVAIL (n=269); CAP (n=566); CAP2 (n=578)...
May 11, 2018: Circulation
https://www.readbyqxmd.com/read/29746708/left-atrial-thrombus-two-years-after-placement-of-a-left-atrial-appendage-closure-device
#17
David H Yoo, Brian Clark, Daniel Nguyen, Timm-Michael Dickfeld, Andrew S Zohlman, Libin Wang, Vincent Y See
A 72-year-old man who underwent a left atrial appendage (LAA) closure device two years ago, presented with atrial flutter with rapid ventricular rate and was referred for cardioversion. Pre-cardioversion transesophageal echocardiogram (TEE) showed left atrial thrombus and therefore the procedure was aborted. Currently, there is no guideline on imaging surveillance or anticoagulation in patients with LAA closure device who develop intracardiac thrombus after the initial six month surveillance period. This article is protected by copyright...
May 10, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29743994/approaches-to-left-atrial-appendage-closure-device-design-performance-and-limitations
#18
REVIEW
Amish S Dave, Miguel Valderrábano
Up to 6.1 million people in the United States have atrial fibrillation (AF), which is associated with an increased risk of stroke. Oral anticoagulants are the mainstay of stroke prevention in AF. For decades, warfarin was the only available drug, fraught with compliance limitations, a narrow therapeutic window, and a high risk of hemorrhage. Pharmacologic developments have produced new anticoagulants that have improved the rates of stroke related to AF; however, they still confer a high risk of bleeding, making them unsuitable for some patients...
July 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29739915/cost-effectiveness-of-left-atrial-appendage-closure-with-the-watchman-device-compared-with-warfarin-or-non-vitamin-k-antagonist-oral-anticoagulants-for-secondary-prevention-in-nonvalvular-atrial-fibrillation
#19
Vivek Y Reddy, Ronald L Akehurst, Stacey L Amorosi, Meghan B Gavaghan, Deanna S Hertz, David R Holmes
BACKGROUND AND PURPOSE: Once a patient with atrial fibrillation experiences an embolic event, the risk of a recurrent event increases 2.6-fold. New treatments have emerged as viable treatment alternatives to warfarin for stroke risk reduction in secondary prevention populations. This analysis sought to assess the cost-effectiveness of left atrial appendage closure (LAAC) compared with warfarin and the non-vitamin K antagonist oral anticoagulants dabigatran 150 mg, apixaban and rivaroxaban in the prevention of stroke in nonvalvular atrial fibrillation patients with a prior stroke or transient ischemic attack...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29737618/long-term-follow-up-of-3-t-mri-detected-brain-lesions-after-percutaneous-catheter-based-left-atrial-appendage-closure
#20
Barbara Bellmann, Andreas Rillig, Carsten Skurk, David Manuel Leistner, Karl Georg Haeusler, Tina Lin, Rohat Geran, Luzie Koehler, Selma Guttmann, Verena Tscholl, Mattias Roser, Klaus Lenz, Kersten Villringer, Jai- Wun Park, Jochen B Fiebach, Ulf Landmesser
BACKGROUND: Left atrial appendage closure (LAAC) for stroke prevention is an increasingly performed intervention. AIMS: This prospective study aims to evaluate the incidence of long-term magnetic resonance imaging (MRI)-detected brain lesions as well as potential changes of neurocognitive function after percutaneous LAAC. METHODS: Brain MRI at 3 T was performed within 24 hr before and after LAAC. A follow-up MRI was carried out after three months...
May 8, 2018: Catheterization and Cardiovascular Interventions
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