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pernicious anemia and gastric cancer

https://read.qxmd.com/read/32213076/gastric-cancer-in-autoimmune-gastritis-a-case-control-study-from-the-german-centers-of-the-star-project-on-gastric-cancer-research
#21
MULTICENTER STUDY
Friederike Weise, Michael Vieth, Dirk Reinhold, Johannes Haybaeck, Elisabetta Goni, Hans Lippert, Karsten Ridwelski, Philipp Lingohr, Claus Schildberg, Nikolaos Vassos, Martin Kruschewski, Iurii Krasniuk, Peter P Grimminger, Oliver Waidmann, Ulrich Peitz, Lothar Veits, Nicole Kreuser, Hauke Lang, Christiane Bruns, Markus Moehler, Florian Lordick, Ines Gockel, Johannes Schumacher, Peter Malfertheiner, Marino Venerito
OBJECTIVES: Patients with autoimmune gastritis (AIG) are reported to have an increased risk of developing gastric cancer (GC). In this study, we assess the characteristics and outcomes of GC patients with AIG in a multicenter case-control study. METHODS: Between April 2013 and May 2017, patients with GC, including cancers of the esophagogastric junction (EGJ) Siewert type II and III, were recruited. Patients with histological characteristics of AIG were identified and matched in a 1:2 fashion for age and gender to GC patients with no AIG...
March 2020: United European Gastroenterology Journal
https://read.qxmd.com/read/31501152/serologic-profile-of-antiparietal-cell-antibodies-pepsinogens-and-h-pylori-and-risk-of-upper-gastrointestinal-cancer-a-nested-case-control-study-in-china
#22
JOURNAL ARTICLE
Shao-Ming Wang, Mark J Roth, Gwen A Murphy, Sanford M Dawsey, Jin-Hu Fan, Philip R Taylor, You-Lin Qiao, Christian C Abnet
BACKGROUND: Autoimmune gastritis is understudied and possibly associated with gastric noncardia adenocarcinoma (GNCA) and esophageal squamous cell carcinoma (ESCC) in Western populations when it presents as pernicious anemia. METHODS: A nested case-control study within a Chinese cohort included 100 ESCC, 200 gastric cardia adenocarcinoma (GCA), and 200 GNCA cases diagnosed between 1986 and 2001 and 400 controls. Serostatus of antiparietal cell antibodies (APCA), Helicobacter pylori antibodies, and pepsinogens were measured using commercial kits and serum collected at baseline...
December 2019: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/31048663/autoimmune-diseases-and-gastric-cancer-risk-a-systematic-review-and-meta-analysis
#23
JOURNAL ARTICLE
Minkyo Song, Gonzalo Latorre, Danisa Ivanovic-Zuvic, M Constanza Camargo, Charles S Rabkin
PURPOSE: Autoimmunity is an alternative etiology of gastric inflammation, the initiating event in the gastric carcinogenic cascade. This mechanism may be an increasingly important cause of gastric cancer with the waning prevalence of its primary etiologic factor, chronic Helicobacter pylori infection. MATERIALS AND METHODS: PubMed and EMBASE were searched up to September 2018. Autoimmunity and 96 specific manifestations were considered for associations with gastric cancer risk...
July 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/30765662/-a-case-of-advanced-cardia-gastric-cancer-with-pernicious-anemia
#24
JOURNAL ARTICLE
Takashi Katsumori, Hisami Ohshima, Hiromitsu Hamaguchi, Shinichi Yamamoto, Yukika Tsukamoto, Tomohiro Iwanaga, Susumu Ohkawara
A 70s male was referred to our hospital with anemia that was detected during a medical checkup. Upper gastrointestinal endoscopy showed advanced cardia gastric cancer. A diagnosis of pernicious anemia was made due to the macrocytic hyperchromic anemia and detection of intrinsic factor antibody. A CT scan showed fundic wall thickening and regional lymph node metastasis. After anemia improved following vitamin B12 injection, total gastrectomy with lymphadenectomy was performed. The histopathological findings showed adenocarcinoma(tub1>tub2), Type2 , pT3(SS), pN1(2/24), Stage ⅡB, INF b, ly1, v2, PM0, DM0, EW(+), pR1...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30598594/the-incidence-of-neoplasia-in-patients-with-autoimmune-metaplastic-atrophic-gastritis-a-renewed-call-for-surveillance
#25
JOURNAL ARTICLE
Nadim Mahmud, Kristen Stashek, Bryson W Katona, Rashmi Tondon, Stuti G Shroff, Robert Roses, Emma E Furth, David C Metz
BACKGROUND: Autoimmune metaplastic atrophic gastritis (AMAG) is an immune-mediated process that may lead to pernicious anemia (PA) and an increased risk of gastric cancer. Although some literature supports 3- or 5-year endoscopic surveillance for gastric cancer in patients with PA, no formal guidance exists for the general AMAG population. We sought to identify the prevalence and incidence rates of dysplasia or adenocarcinoma in patients with AMAG in order to clarify endoscopic best practices...
January 2019: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://read.qxmd.com/read/30317974/chronic-atrophic-gastritis-a-review
#26
REVIEW
Yifei Li, Ran Xia, Bo Zhang, Chunsheng Li
Chronic atrophic gastritis is a generally asymptomatic condition of great importance because it develops into gastric cancer in a number of patients. It is described as an atrophy of the gastric mucosa. There are two types of atrophic gastritis: a gastric body predominant type in patients with infection of Helicobacter pylori, and an autoimmune type, limited to the gastric body and fundus. The autoimmune type is quite rare and affects people of all ethnicities. Globally, H. pylori infection is very common and is considered a class I carcinogen due to the large number of patients who subsequently develop gastric cancer...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/27531538/gastric-cancer-clinical-and-epidemiological-aspects
#27
REVIEW
Marino Venerito, Alexander Link, Theodoros Rokkas, Peter Malfertheiner
Gastric cancer (GC) ranks fifth for cancer incidence and second for cancer deaths. Epidemiological data showed that survivors of Hodgkin's lymphoma and patients with pernicious anemia etiologically linked to autoimmune gastritis are at increased risk of GC. Screening of patients with autoimmune thyroid disease by means of pepsinogen (PG) I and PG I/II detected autoimmune gastritis with oxyntic gastric atrophy in one of four patients and may be recommended for GC prevention purposes. The International Agency for Research on Cancer reported a positive association between consumption of processed meet and increased GC risk...
September 2016: Helicobacter
https://read.qxmd.com/read/26560097/safety-of-proton-pump-inhibitors-and-risk-of-gastric-cancers-review-of-literature-and-pathophysiological-mechanisms
#28
REVIEW
Yanna Ko, James Tang, Santosh Sanagapalli, Bong Sik Matthew Kim, Rupert W Leong
INTRODUCTION: Despite being an overall safe drug, several long-term adverse effects are associated with proton pump inhibitors (PPIs). The link between PPI use and gastric neuroendocrine tumors (NETs), gastric adenocarcinomas and Barrett's esophagus progression gastric cancers has been investigated due to PPI-induced hypergastrinemia. AREAS COVERED: The pathophysiological mechanisms underlying PPI exposure and gastric NETs, gastric adenocarcinomas and Barrett's esophagus progression are discussed...
January 2016: Expert Opinion on Drug Safety
https://read.qxmd.com/read/26079040/cancer-risk-after-pernicious-anemia-in-the-us-elderly-population
#29
JOURNAL ARTICLE
Gwen Murphy, Sanford M Dawsey, Eric A Engels, Winnie Ricker, Ruth Parsons, Arash Etemadi, Shih-Wen Lin, Christian C Abnet, Neal D Freedman
BACKGROUND & AIMS: Pernicious anemia, a result of autoimmune gastritis, is the most common cause of vitamin B12 deficiency, affecting 2% to 5% of the elderly population. Treatment with vitamin B12 cures the anemia, but not the gastritis. Findings from small studies have indicated that patients with pernicious anemia could have an increased risk of cancer. METHODS: We performed a population-based, case-control study of individuals in the Surveillance, Epidemiology, and End Results-Medicare database, comparing 1,138,390 cancer cases (age, 66-99 y) with 100,000 matched individuals without cancer (controls)...
December 2015: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/25665655/gastric-neuroendocrine-tumors-prevalence-in-europe-usa-and-japan-and-rationale-for-treatment-with-a-gastrin-cck2-receptor-antagonist
#30
JOURNAL ARTICLE
Malcolm Boyce, Liv Thomsen
OBJECTIVE: Gastric carcinoids (neuroendocrine tumors) arise from enterochromaffin-like cells in the gastric mucosa. Most are caused by hypergastrinemia. The objectives were to determine if their prevalence in Europe, USA and Japan meets the criteria for an orphan disease and to justify treatment with a gastrin/CCK2 receptor antagonist. METHODS: We obtained data from European and USA cancer registries, and searched PubMed. RESULTS: Prevalence per 10,000 population obtained from cancer registries was: median 0...
May 2015: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/25213471/thyro-gastric-autoimmunity-in-patients-with-differentiated-thyroid-cancer-a-prospective-study
#31
JOURNAL ARTICLE
Francesco Cicone, Annalisa Papa, Chiara Lauri, Anna Tofani, Camilla Virili, Marco Centanni, Francesco Scopinaro, Bruno Annibale
Thyro-gastric autoimmunity has not been previously evaluated in patients with differentiated thyroid cancer (DTC), although its long-term complications may be relevant for the management of DTC patients. We assessed the prevalence of gastric autoimmunity and autoimmune gastritis (AG) in patients with Hashimoto's thyroiditis (HT) and concomitant DTC. Prevalence of parietal cell antibody (PCA) positivity, iron deficiency anemia (IDA), and pernicious anemia (PA) were prospectively assessed in 150 DTC patients referred for radioiodine ablation after total thyroidectomy...
May 2015: Endocrine
https://read.qxmd.com/read/24890255/gastric-cancer-in-patients-with-type-i-gastric-carcinoids
#32
JOURNAL ARTICLE
Edith Lahner, Gianluca Esposito, Emanuela Pilozzi, Gloria Galli, Vito D Corleto, Emilio Di Giulio, Bruno Annibale
BACKGROUND: Atrophic body gastritis (ABG) is associated with both type I gastric carcinoids (T1-GCs) and intestinal-type gastric cancer. The occurrence of gastric cancer in ABG patients with type I gastric carcinoids has not yet been described. AIM: To describe the occurrence at follow-up of gastric cancer in ABG patients with type I gastric carcinoid in a retrospective case series in a single tertiary referral center. METHODS: Between 1994 and 2012, 17 new cases of T1-GCs were diagnosed among a cohort of ABG patients in a single tertiary referral center for ABG...
July 2015: Gastric Cancer
https://read.qxmd.com/read/24424200/diagnosis-and-classification-of-pernicious-anemia
#33
REVIEW
Nicola Bizzaro, Antonio Antico
Pernicious anemia (PA) is a complex disorder consisting of hematological, gastric and immunological alterations. Diagnosis of PA relies on histologically proven atrophic body gastritis, peripheral blood examination showing megaloblastic anemia with hypersegmented neutrophils, cobalamin deficiency and antibodies to intrinsic factor and to gastric parietal cells. Anti-parietal cell antibodies are found in 90% of patients with PA, but have low specificity and are seen in atrophic gastritis without megaloblastic anemia as well as in various autoimmune disorders...
2014: Autoimmunity Reviews
https://read.qxmd.com/read/23425147/interleukin-21-and-tumor-necrosis-factor-%C3%AE-are-critical-for-the-development-of-autoimmune-gastritis-in-mice
#34
JOURNAL ARTICLE
Hisayo Nishiura, Satoru Iwamoto, Masahiro Kido, Nobuhiro Aoki, Ryutaro Maruoka, Aki Ikeda, Tsutomu Chiba, Norihiko Watanabe
BACKGROUND AND AIM: Autoimmune gastritis (AIG), an organ-specific autoimmune disease, is accompanied by achlorhydria, pernicious anemia, gastric carcinoid tumors, and gastric cancer. Patients with AIG initially respond to corticosteroids but have a great potential to relapse after treatment is withdrawn. This study examines the roles of cytokines in order to identify potential therapeutic options for AIG patients. METHODS: Using a mouse model of AIG, we monitored disease progression and administered antibodies in vivo to block cytokines...
June 2013: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/23216458/systematic-review-gastric-cancer-incidence-in-pernicious-anaemia
#35
REVIEW
L Vannella, E Lahner, J Osborn, B Annibale
BACKGROUND: Pernicious anaemia (PA) has an increased risk for gastric cancer (GC). It is not established whether PA patients need to undergo endoscopic/histological follow-up. AIM: To provide a systematic overview of the literature on PA and the development of gastric cancer, to estimate the gastric cancer incidence-rate. METHODS: According to PRISMA, we identified studies on PA patients reporting the incidence of gastric cancer. Quality of studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale...
February 2013: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/21947876/diagnosis-and-management-of-pernicious-anemia
#36
REVIEW
Bruno Annibale, Edith Lahner, Gianfranco Delle Fave
Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. Pernicious anemia is associated with atrophic body gastritis, whose diagnostic criteria are based on the histologic evidence of gastric body atrophy associated with hypochlorhydria. Serological markers suggesting the presence of oxyntic mucosa damage are increased levels of fasting gastrin and decreased levels of Pepsinogen I. Without the now obsolete Schilling's test, intrinsic factor deficiency may not be proven, and gastric intrinsic factor output after pentagastric stimulation has been proposed...
December 2011: Current Gastroenterology Reports
https://read.qxmd.com/read/21470209/review-of-gastric-cancer-risk-factors-in-patients-with-common-variable-immunodeficiency-disorders-resulting-in-a-proposal-for-a-surveillance-programme
#37
REVIEW
F Dhalla, S P da Silva, M Lucas, S Travis, H Chapel
Common variable immunodeficiency disorders (CVIDs) are the most frequent symptomatic primary immunodeficiencies in adults. They comprise a heterogeneous group of pathologies, with frequent non-infectious complications in addition to the bacterial infections that usually characterize their presentation. Complications include a high risk of malignancy, especially lymphoma and gastric cancer. Helicobacter pylori infection and pernicious anaemia are risk predictors for gastric cancer in the general population and probably in patients with CVIDs...
July 2011: Clinical and Experimental Immunology
https://read.qxmd.com/read/21139361/-case-report-of-rheumatoid-arthritis-associated-with-type-a-gastritis-and-hashimoto-thyroiditis
#38
REVIEW
Emiko Nakao, Atsushi Mitsunaga, Tetsuya Hamano, Miho Shirato, Izumi Shirato, Takayoshi Nishino
A 59-year-old woman was initially thought to have either type A gastritis, or autoimmune gastritis by upper-gastrointestinal-tract endoscopy and a serological examination. Furthermore, the patient was also suspected to have Hashimoto disease based on a positive antithyroid-antibody test. Rheumatoid arthritis was diagnosed 1 year later. Pernicious anemia, gastric-carcinoid and stomach cancer are the primary complications of A type gastritis. However, we hypothesized that the development of other autoimmune diseases, such as autoimmune thyroid disease, was the primary complication experienced in this case...
December 2010: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://read.qxmd.com/read/21088409/gastric-cancer-epidemiology-and-risk-factors
#39
JOURNAL ARTICLE
Guenter J Krejs
The incidence of gastric cancer is decreasing and lies between 10 and 15 new cases per 100,000 population per year in most Western countries. Peak age is between 60 and 80 years. While distal gastric cancers account for the overall decrease in gastric cancer, tumors in the proximal stomach (cardia and esophagogastric junction) are on the rise. Recognized risk factors for gastric cancer are infection with Helicobacter pylori, dietary factors (e.g. high intake of salt-preserved foods), smoking, pernicious anemia and a history of partial gastrectomy...
2010: Digestive Diseases
https://read.qxmd.com/read/20388948/can-gastric-cancer-be-prevented
#40
REVIEW
B Tepes
Gastric adenocarcinoma is the fourth most common malignancy worldwide and is globally the second leading cause of cancer-related deaths each year. Among the risk factors are genetic factors (genetic diffuse gastric cancer - E-cadherin mutation (CDH1), pro- and anti-inflammatory cytokine genes and innate immune response gene polymorphisms), environmental factors (infection with the bacterium Helicobacter pylori (H. pylori), Epstein-Barr virus, nutrition: nitroso compounds, salt and antioxidants intake) and other factors (pernicious anemia, gastric polyps, gastric surgery, reproductive hormones, smoking)...
December 2009: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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