keyword
https://read.qxmd.com/read/38516807/geographic-variation-in-larval-cold-tolerance-and-exposure-across-the-invasion-front-of-a-widely-established-forest-insect
#21
JOURNAL ARTICLE
Petra Hafker, Lily M Thompson, Jonathan A Walter, Dylan Parry, Kristine L Grayson
Under global climate change, high and low temperature extremes can drive shifts in species distributions. Across the range of a species, thermal tolerance is based on acclimatization, plasticity, and may undergo selection, shaping resilience to temperature stress. In this study, we measured variation in cold temperature tolerance of early instar larvae of an invasive forest insect, Lymantria dispar dispar L. (Lepidoptera: Erebidae), using populations sourced from a range of climates within the current introduced range in the Eastern United States...
March 22, 2024: Insect Science
https://read.qxmd.com/read/38513223/long-term-exposure-to-air-pollution-and-risk-of-acute-lower-respiratory-infections-in-the-danish-nurse-cohort
#22
JOURNAL ARTICLE
Jiawei Zhang, Youn-Hee Lim, Rina So, Laust H Mortensen, George Maria Napolitano, Thomas Cole-Hunter, Stéphane Tuffier, Marie Bergmann, Matija Maric, Seyed Mahmood Taghavi Shahri, Jørgen Brandt, Matthias Ketzel, Steffen Loft, Zorana Jovanovic Andersen
RATIONALE: Air pollution is a major risk factor for chronic cardiorespiratory diseases, affecting both the immune and respiratory systems' functionality, while the epidemiological evidence on respiratory infections remains sparse. OBJECTIVE: We aimed to assess the association of long-term exposure to ambient air pollution with risk of developing new and recurrent ALRIs that characterized by persistently severe symptoms necessitating hospital contact, and identify the potential susceptible populations by socio-economic status (SES), smoking, physical activity status, overweight, and co-morbidity with chronic lung disease...
March 21, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38507607/the-effect-of-chronic-altitude-exposure-on-copd-outcomes-in-the-spiromics-cohort
#23
JOURNAL ARTICLE
Rajat Suri, Daniela Markovic, Han Woo, Mehrdad Arjomandi, R Graham Barr, Russell P Bowler, Gerard Criner, Jeffrey L Curtis, Mark T Dransfield, M Bradley Drummond, Spyridon Fortis, MeiLan K Han, Eric A Hoffman, Robert J Kaner, Joel D Kaufman, Jerry A Krishnan, Fernando J Martinez, Jill Ohar, Victor E Ortega, Robert Paine Iii, Xavier Soler, Prescott G Woodruff, Nadia N Hansel, Christopher B Cooper, Donald P Tashkin, Russell G Buhr, Igor Z Barjaktarevic
RATIONALE: Individuals with COPD have airflow obstruction and maldistribution of ventilation. For those living at high altitude, any gas exchange abnormality is compounded by reduced partial pressures of inspired oxygen. OBJECTIVES: Does residence at higher-altitude exposure affect COPD outcomes, including lung function, imaging characteristics, symptoms, health status, functional exercise capacity, exacerbations, or mortality? METHODS: From the SPIROMICS cohort, we identified individuals with COPD living below 1,000 ft (305 m) elevation (n= 1,367) versus above 4,000 ft (1,219 m) elevation (n= 288)...
March 20, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38507092/air-pollution-and-upper-respiratory-diseases-an-examination-among-medically-insured-populations-in-wuhan-china
#24
JOURNAL ARTICLE
Tianyu Liu, Yuehua Liu, Yaqian Su, Jiayuan Hao, Suyang Liu
Multiple evidence has supported that air pollution exposure has detrimental effects on the cardiovascular and respiratory systems. However, most investigations focus on the general population, with limited research conducted on medically insured populations. To address this gap, the current research was designed to examine the acute effects of inhalable particulate matter (PM2.5 and PM10 ), nitrogen dioxide (NO2 ), ground-level ozone (O3 ), and sulfur dioxide (SO2 ) on the incidence of upper respiratory tract infections (URTI), utilizing medical insurance data in Wuhan, China...
March 20, 2024: International Journal of Biometeorology
https://read.qxmd.com/read/38505614/depletion-of-apoa5-aggravates-spontaneous-and-diet-induced-nonalcoholic-fatty-liver-disease-by-reducing-hepatic-nr1d1-in-hamsters
#25
JOURNAL ARTICLE
Jiabao Guo, Guolin Miao, Wenxi Zhang, Haozhe Shi, Pingping Lai, Yitong Xu, Lianxin Zhang, Gonglie Chen, Yufei Han, Ying Zhao, Geroge Liu, Ling Zhang, Yuhui Wang, Wei Huang, Xunde Xian
Background: ApoA5 mainly synthesized and secreted by liver is a key modulator of lipoprotein lipase (LPL) activity and triglyceride-rich lipoproteins (TRLs). Although the role of ApoA5 in extrahepatic triglyceride (TG) metabolism in circulation has been well documented, the relationship between ApoA5 and nonalcoholic fatty liver disease (NAFLD) remains incompletely understood and the underlying molecular mechanism still needs to be elucidated. Methods: We used CRISPR/Cas9 gene editing to delete Apoa5 gene from Syrian golden hamster, a small rodent model replicating human metabolic features...
2024: Theranostics
https://read.qxmd.com/read/38505502/nociceptive-flexion-reflex-threshold-is-no-suitable-marker-for-diagnosing-opioid-induced-hyperalgesia
#26
JOURNAL ARTICLE
Luisa Trübenbacher, Nicole Lindenberg, Bernhard M Graf, Markus Backmund, Wilhelm Unglaub, Christoph L Lassen
BACKGROUND: Opioid induced hyperalgesia (OIH) describes a state of altered pain sensation due to opioid exposure. It often occurs among persons with opioid use disorder receiving substitution therapy. METHODS: The purpose of this study was to find out, whether OIH diagnosis could be facilitated by an objective pain indicating marker: the Nociceptive Flexion Reflex (NFR). Forty persons with opioid use disorder, 20 of them maintained on methadone and 20 treated with buprenorphine, as well as a control group of 20 opioid-free subjects, were examined...
2024: Journal of Pain Research
https://read.qxmd.com/read/38504975/human-tissue-resident-peritoneal-macrophages-reveal-resistance-towards-oxidative-cell-stress-induced-by-non-invasive-physical-plasma
#27
JOURNAL ARTICLE
Laura Schultze-Rhonhof, Julia Marzi, Daniel Alejandro Carvajal Berrio, Myriam Holl, Theresa Braun, Felix Schäfer-Ruoff, Jürgen Andress, Cornelia Bachmann, Markus Templin, Sara Y Brucker, Katja Schenke-Layland, Martin Weiss
In the context of multimodal treatments for abdominal cancer, including procedures such as cytoreductive surgery and intraperitoneal chemotherapy, recurrence rates remain high, and long-term survival benefits are uncertain due to post-operative complications. Notably, treatment-limiting side effects often arise from an uncontrolled activation of the immune system, particularly peritoneally localized macrophages, leading to massive cytokine secretion and phenotype changes. Exploring alternatives, an increasing number of studies investigated the potential of plasma-activated liquids (PAL) for adjuvant peritoneal cancer treatment, aiming to mitigate side effects, preserve healthy tissue, and reduce cytotoxicity towards non-cancer cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38503017/interleukin-2-anti-interleukin-2-complex-attenuates-inflammation-in-a-mouse-copd-model-by-expanding-cd4-cd25-foxp3-regulatory-t-cells
#28
JOURNAL ARTICLE
Ruirui Duan, Ke Huang, Tao Yu, Chenli Chang, Xu Chu, Yuhang Huang, Zhoude Zheng, Linxi Ma, Baicun Li, Ting Yang
BACKGROUND AND PURPOSE: Chronic, nonspecific inflammation of the alveoli and airways is an important pathological feature of chronic obstructive pulmonary disease (COPD), while sustained inflammatory reactions can cause alveolar damage. Regulatory T cells (Tregs) inhibit inflammation, whereas the interleukin-2/anti-interleukin-2 complex (IL-2C) increases the number of Tregs; however, whether the IL-2C has a therapeutic role in COPD remains unknown. Therefore, this study investigated whether IL-2C alleviates lung inflammation in COPD by increasing the number of Tregs...
March 18, 2024: International Immunopharmacology
https://read.qxmd.com/read/38496885/high-altitude-balloon-platform-for-studying-the-biological-response-of-living-organisms-exposed-to-near-space-environments
#29
JOURNAL ARTICLE
Sumeth Klomchitcharoen, Pongsakorn Wechakarn, Tanchanok Tangwattanasirikun, Noparin Smerwong, Phubase Netrapathompornkij, Thanapat Chatmeeboon, Norawit Nangsue, Vivatsathorn Thitasirivit, Krin Kaweewongsunthorn, Suvijak Piyanopharoj, Phachara Phumiprathet, Yodchanan Wongsawat
The intangible desire to explore the mysteries of the universe has driven numerous advancements for humanity for centuries. Extraterrestrial journeys are becoming more realistic as a result of human curiosity and endeavors. Over the years, space biology research has played a significant role in understanding the hazardous effects of the space environment on human health during long-term space travel. The inevitable consequence of a space voyage is space ionizing radiation, which has deadly aftereffects on the human body...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496094/a-glomus-tumor-presenting-on-the-ventromedial-aspect-of-the-little-finger-causing-bony-erosion-a-rare-case-from-india
#30
Swaroop Solunke, Pratik T Gundecha, Archit Gupta, Rahul Salunkhe, Abhishek Nair
Glomus tumors are rare neoplasms originating from the glomus body that predominantly manifest in the subungual region of the digits and are distinguished by severe pain and a heightened sensitivity to cold. Bony erosion associated with glomus tumors is a rare phenomenon. Here, we present a unique case of a glomus tumor situated on the ventromedial aspect of the little finger, leading to notable bony erosion. A 42-year-old female from India presented with a chief complaint of severe and localized pain in the ventromedial region of her right little finger, exacerbated by exposure to cold temperatures...
February 2024: Curēus
https://read.qxmd.com/read/38494014/characterization-and-childhood-exposure-assessment-of-toxic-heavy-metals-in-household-dust-under-true-living-conditions-from-10-china-cities
#31
JOURNAL ARTICLE
Yun Cao, Mengmeng Liu, Wenying Zhang, Xiaotong Zhang, Xu Li, Chao Wang, Weiyi Zhang, Hang Liu, Xianliang Wang
Health hazards caused by metal exposure in household dust are concerning environmental health problems. Exposure to toxic metals in household dust imposes unclear but solid health risks, especially for children. In this multicenter cross-sectional study, a total of 250 household dust samples were collected from ten stratified cities in China (Panjin, Shijiazhuang, Qingdao, Lanzhou, Luoyang, Ningbo, Xi'an, Wuxi, Mianyang, Shenzhen) between April 2018 and March 2019. Questionnaire was conducted to gather information on individuals' living environment and health status in real-life situations...
March 15, 2024: Science of the Total Environment
https://read.qxmd.com/read/38491303/the-effect-of-breathing-exercises-and-mindset-with-or-without-cold-exposure-on-mental-and-physical-health-in-persons-with-a-spinal-cord-injury-a-protocol-for-a-three-arm-randomised-controlled-trial
#32
JOURNAL ARTICLE
Sven Hoekstra, Frank Ettema, Max van der Bijll, Vera van der Sterren, Ellen van Binsbergen, Ludwine van Orsouw, Wendy Achterberg, Hein Daanen, Thomas Janssen, Sonja de Groot
STUDY DESIGN: A three-arm randomized controlled trial. OBJECTIVES: To investigate the effects of the Wim Hof Method (WHM), with (WHM-C) and without cold exposure (WHM-NC), on mental and physical health in persons with chronic spinal cord injury (SCI). SETTING: Rehabilitation centre (assessments and once-weekly intervention sessions) and home-based (daily intervention sessions). METHODS: Sixty adults with chronic SCI will be randomised (1:1:1) to one of three groups: participants in the intervention groups (i...
March 15, 2024: Spinal Cord
https://read.qxmd.com/read/38489784/building-envelope-inspired-thermomechanically-robust-all-fiber-ceramic-meta-aerogel-for-temperature-controlled-dominant-infrared-camouflage
#33
JOURNAL ARTICLE
Hualei Liu, Xinxin Zhang, Yalong Liao, Jianyong Yu, Yi-Tao Liu, Bin Ding
The unsatisfactory properties of ceramic aerogels when subjected to thermal shock, such as strength degradation and structural collapse, render them unsuitable for use at large thermal gradients or prolonged exposure to extreme temperatures. Here we present a building-envelope-inspired design for fabricating a thermomechanically robust all-fiber ceramic meta-aerogel with interlocked fibrous interfaces and an interwoven cellular structure in the orthogonal directions, which is achieved through a two-stage physical and chemical process...
March 15, 2024: Advanced Materials
https://read.qxmd.com/read/38488998/factors-triggering-familial-mediterranean-fever-attacks-do-they-really-exist
#34
JOURNAL ARTICLE
Kerem Parlar, Muhammed Bahaddin Ates, Mehmet Erinc Onal, Ece Bostancı, Feyza Nur Azman, Serdal Uğurlu
Several possible factors are hypothesized to trigger familial Mediterranean fever (FMF) attacks; however, there is no consensus on this matter. We aimed to identify these triggering factors and analyze their relationship with the Mediterranean fever gene mutation status. We prepared a questionnaire that included the most commonly mentioned possible trigger factors of familial Mediterranean fever. We administered a questionnaire to 882 patients. We used a questionnaire assessing the following: psychological stress, consumption of tea and coffee, relationship with menses, menopause and post-menopausal alleviation, seasonal changes, traveling for long durations, relocation, starvation, sleeplessness, cold exposure, fatigue, wind exposure, and humidity...
March 15, 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/38484265/lung-function-evaluated-by-structured-light-plethysmography-in-children-after-lung-surgery-a-preliminary-analysis
#35
JOURNAL ARTICLE
Michele Ghezzi, Luisa Abbattista, Anna Dighera, Annalisa De Silvestri, Andrea Farolfi, Gloria Pelizzo, Giovanna Riccipetitoni, Sara Costanzo, Valeria Calcaterra, Gian Vincenzo Zuccotti
Background: Structured light plethysmography (SLP) is a novel light-based method that captures chest wall movements to evaluate tidal breathing. Methods: Thirty-two children who underwent lung surgery were enrolled. Their clinical history was collected along with spirometry and SLP. Results: Median age of surgery was 9 months (interquartile range 4-30). Most frequent diagnosis was congenital pulmonary airway malformation (14/32), then pulmonary sequestration (9/32), tumor (5/32), and bronchogenic cyst (4/32)...
March 2024: Pediatric Allergy, Immunology, and Pulmonology
https://read.qxmd.com/read/38482916/local-climate-and-vernalization-sensitivity-predict-the-latitudinal-patterns-of-flowering-onset-in-the-crop-wild-relative-linum-bienne-mill
#36
JOURNAL ARTICLE
Beatrice Landoni, Pilar Suárez-Montes, Rico H F Habeahan, Adrian C Brennan, Rocío Pérez-Barrales
BACKGROUND AND AIMS: The timing of flowering onset often correlates with latitude, indicative of climatic gradients. Flowering onset in temperate species commonly requires exposure to cold temperatures, known as vernalization. Hence, population differentiation of flowering onset with latitude might reflect adaptation to the local climatic conditions experienced by populations. METHODS: Within its Western range, seeds from Linum bienne populations (the wild relative of cultivated L...
March 14, 2024: Annals of Botany
https://read.qxmd.com/read/38482267/assessing-the-oxidative-potential-of-outdoor-pm-2-5-in-wintertime-fairbanks-alaska
#37
JOURNAL ARTICLE
Yuhan Yang, Michael A Battaglia, Magesh Kumaran Mohan, Ellis S Robinson, Peter F DeCarlo, Kasey C Edwards, Ting Fang, Sukriti Kapur, Manabu Shiraiwa, Meeta Cesler-Maloney, William R Simpson, James R Campbell, Athanasios Nenes, Jingqiu Mao, Rodney J Weber
The oxidative potential (OP) of outdoor PM2.5 in wintertime Fairbanks, Alaska, is investigated and compared to those in wintertime Atlanta and Los Angeles. Approximately 40 filter samples collected in January-February 2022 at a Fairbanks residential site were analyzed for OP utilizing dithiothreitol-depletion (OPDTT ) and hydroxyl-generation (OPOH ) assays. The study-average PM2.5 mass concentration was 12.8 μg/m3 , with a 1 h average maximum of 89.0 μg/m3 . Regression analysis, correlations with source tracers, and contrast between cold and warmer events indicated that OPDTT was mainly sensitive to copper, elemental carbon, and organic aerosol from residential wood burning, and OPOH to iron and organic aerosol from vehicles...
March 8, 2024: ACS EST Air
https://read.qxmd.com/read/38481768/validity-of-cold-storage-and-heat-treatment-on-the-deactivation-of-vibrio-parahaemolyticus-isolated-from-fish-meat-markets
#38
JOURNAL ARTICLE
Maged A Al-Garadi, Rasha N Aziz, Dhary Alewy Almashhadany, Dheyazan M Ali Al Qabili, Abdulmunem Dherar Abdullah Aljoborey
Vibrio parahaemolyticus is a zoonotic disease transmitted to humans when handling or consuming improperly cooked fish meat. This study aimed to evaluate the effect of thermal treatment on V. parahaemolyticus isolates. Different heat treatment methods are used to determine the best methods for controlling V. parahaemolyticus , isolated from fish meat, which include microwave, low-temperature long-time, and high-temperature short-time methods. The V. parahaemolyticus isolates significantly declined in bacteria count when they were kept at 4°C, and 25°C for a long time, and the V...
February 22, 2024: Italian Journal of Food Safety
https://read.qxmd.com/read/38480743/intestinal-dual-specificity-phosphatase-6-regulates-the-cold-induced-gut-microbiota-remodeling-to-promote-white-adipose-browning
#39
JOURNAL ARTICLE
Pei-Chen Chen, Tzu-Pei Tsai, Yi-Chu Liao, Yu-Chieh Liao, Hung-Wei Cheng, Yi-Hsiu Weng, Chiao-Mei Lin, Cheng-Yuan Kao, Chih-Cheng Tai, Jhen-Wei Ruan
Gut microbiota rearrangement induced by cold temperature is crucial for browning in murine white adipose tissue. This study provides evidence that DUSP6, a host factor, plays a critical role in regulating cold-induced gut microbiota rearrangement. When exposed to cold, the downregulation of intestinal DUSP6 increased the capacity of gut microbiota to produce ursodeoxycholic acid (UDCA). The DUSP6-UDCA axis is essential for driving Lachnospiraceae expansion in the cold microbiota. In mice experiencing cold-room temperature (CR) transitions, prolonged DUSP6 inhibition via the DUSP6 inhibitor (E/Z)-BCI maintained increased cecal UDCA levels and cold-like microbiota networks...
March 13, 2024: NPJ Biofilms and Microbiomes
https://read.qxmd.com/read/38479188/cold-exposure-affects-glucose-metabolism-lipid-droplet-deposition-and-mitophagy-in-skeletal-muscle-of-newborn-goats
#40
JOURNAL ARTICLE
Duo Su, Yulong Song, Die Li, Shizhong Yang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang
Cold exposure is a common stressor for newborn goats. Skeletal muscle plays an important role in maintaining whole-body homeostasis of glucose and lipid metabolism. However, the molecular mechanisms underlying regulation of skeletal muscle of newborn goats by cold exposure remains unclear. In this study, we found a significant increase (P < 0.01) in serum glucagon levels after 24 h of cold exposure (COLD, 6°C), while glucose and insulin concentrations were significantly decreased (P < 0.01) compared to room temperature (RT, 25°C)...
March 8, 2024: Domestic Animal Endocrinology
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