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https://www.readbyqxmd.com/read/29778012/reactive-oxygen-species-ros-activity-of-ambient-fine-particles-pm-2-5-measured-in-seoul-korea
#1
Jieun Park, Eun Ha Park, James J Schauer, Seung-Muk Yi, Jongbae Heo
Substantial increase in level of particulate matter has raised concerns in South Korea recently. Ambient particulate matter is classified as Group I carcinogen (IARC, 2013) and multiple epidemiological studies has demonstrated adverse health effects due to exposure of particulate matter. Fine particulate matter (PM2.5 ) which has a diameter <2.5 μm is likely to penetrate deeply into lung and is known to be eliciting adverse health effects. A number of epidemiological studies have been conducted on adverse health effects of PM-related diseases and mortality rate, yet particulate matter (PM)-induced reactive oxygen species (ROS) activity at the cellular level has not been actively studied in Korea...
May 16, 2018: Environment International
https://www.readbyqxmd.com/read/29775776/the-probable-roles-of-valsartan-in-alleviating-chronic-obstructive-pulmonary-disease-following-co-exposure-to-cold-stress-and-fine-particulate-matter
#2
Jiangtao Liu, Lei Guo, Kai Zhang, Quanquan Song, Qiaozhen Wei, Qin Bian, Tingting Liang, Jingping Niu, Bin Luo
Angiotensin II (ANG II) might play an important role in the co-effects of cold stress and fine particulate matter (PM2.5 ) on chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate the roles of valsartan in alleviating COPD following co-exposure to cold stress and PM2.5 . Both the two intervention factors are carried out upon COPD rats with the intervention of valsartan. Blockade of angiotensin receptor by valsartan decreases the levels of malondialdehyde in the normal temperature and tumor necrosis factor-α under cold stress significantly...
May 7, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29775611/reduced-adiposity-by-compensatory-wat-browning-upon-ibat-removal-in-mice
#3
Zhengyu Piao, Baiqiang Zhai, Xiaoxiao Jiang, Meng Dong, Changguo Yan, Jun Lin, Wanzhu Jin
The strong effects of classic brown adipose tissue (BAT) and recruited beige adipocytes in treatment of obesity and metabolic syndrome have been attracting increasing research interest. Cold treatment is an effective, convenient approach to stimulate BAT activity and induce white adipose tissue (WAT) browning. Here, we utilized prolonged cold exposure (from 2 h to 2 weeks in a 4° cold chamber) to elucidate dynamic changes in BAT and in WAT browning during acute and chronic cold exposure in mice. BAT mass decreased quickly, with reduced lipid droplet sizes within 8 h of cold exposure owing to the utilization of BAT pre-storage triglycerides, and subsequently increased during prolonged cold exposure...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29772808/mercury-levels-in-women-and-children-from-interior-villages-in-suriname-south-america
#4
Paul E Ouboter, Gwendolyn Landburg, Gaitrie U Satnarain, Sheryl Y Starke, Indra Nanden, Bridget Simon-Friedt, William B Hawkins, Robert Taylor, Maureen Y Lichtveld, Emily Harville, Jeffrey K Wickliffe
Natural sources of mercury, historical gold mining, and contemporary artisanal and small-scale gold mining (ASGM) activities have led to mercury contamination in Suriname. Our primary objective was to evaluate mercury levels in hair of women and children from interior villages in Suriname where mercury levels in fish are elevated. We also estimated blood levels of mercury using an established mathematical conversion to facilitate comparison with other biomonitoring programs in the United States. Estimated levels of mercury in the blood of participants from Suriname were significantly higher than those in women from a heavy marine fish-consuming population in southeast Louisiana and estimates of the US national average...
May 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29771387/functional-brown-adipose-tissue-and-sympathetic-activity-after-cold-exposure-in-humans-with-type-1-narcolepsy
#5
Lotte Hahn Enevoldsen, Marie Tindborg, Nichlas Lindegaard Hovmand, Christina Christoffersen, Helga Ellingsgaard, Charlotte Suetta, Bente Merete Stallknecht, Poul Joergen Jennum, Andreas Kjær, Steen Gammeltoft
Study objectives: To investigate the activity of brown adipose tissue (BAT) in type 1 narcolepsy patients during cold exposure using two separate scans of sympathetic and metabolic activity of BAT in order to evaluate whether orexin deficiency leads to altered non-shivering thermoregulation in narcolepsy. Methods: Seven patients with type 1 narcolepsy and seven healthy controls underwent two consecutive scans after 2 h cold exposure: 123I-meta-iodo-benzyl-guanidine (123I-MIBG) single photon emission computed tomography and 18F-2-deoxy-glucose (18F-FDG) positron emission tomography and computed tomography to visualize sympathetic innervation and metabolic activity of BAT, respectively...
May 15, 2018: Sleep
https://www.readbyqxmd.com/read/29768343/potential-common-factors-associated-with-predisposition-to-common-cold-in-middle-aged-and-elderly-japanese-a-community-based-cross-sectional-study
#6
Michi Shibata, Taizo Iwane, Ryoko Higuchi, Kaname Suwa, Kei Nakajima
People worldwide frequently catch a common cold, which occasionally develops into secondary severe conditions such as pneumonia. However, it is unclear whether predisposition to the common cold is associated with the individual's characteristics including age, body weight, lifestyles, diets, and intestinal functions, besides exposure to a responsible pathogen. We addressed this issue epidemiologically considering many relevant clinical factors.We reviewed data from a cross-sectional study consisting of 39,524 apparently healthy Japanese aged 40 to 79 years (26,975 men and 12,549 women) who underwent a checkup in 2007...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767812/tolerance-of-subzero-winter-cold-in-kudzu-pueraria-montana-var-lobata
#7
Heather A Coiner, Katharine Hayhoe, Lewis H Ziska, Jeff Van Dorn, Rowan F Sage
The use of species distribution as a climate proxy for ecological forecasting is thought to be acceptable for invasive species. Kudzu (Pueraria montana var. lobata) is an important invasive whose northern distribution appears to be limited by winter survival; however, kudzu's cold tolerance thresholds are uncertain. Here, we used biogeographic evidence to hypothesize that exposure to - 20 °C is lethal for kudzu and thus determines its northern distribution limit. We evaluated this hypothesis using survival tests and electrolyte leakage to determine relative conductivity, a measure of cell damage, on 14 populations from eastern North America...
May 16, 2018: Oecologia
https://www.readbyqxmd.com/read/29761290/isolation-and-functional-characterization-of-a-floral-repressor-bcflc2-from-pak-choi-brassica-rapa-ssp-chinensis
#8
Feiyi Huang, Tongkun Liu, Jin Wang, Xilin Hou
BcFLC2 functioned as a repressor of flowering by directly regulating BcTEM1, BcMAF2, BcSOC1 and BcSPL15 in Pak-choi. FLOWERING LOCUS C (FLC) plays an important role in regulating flowering time. Here, we functionally described an FLC homologous gene, BcFLC2, that negatively regulated flowering in Pak-choi (Brassica rapa ssp. chinensis). The sequence comparison to Arabidopsis FLC showed that BcFLC2 also had a MADS-box domain at the N terminus. BcFLC2 was highly expressed in the leaves, roots, stems and stamens, and its expression was repressed by vernalization in Pak-choi...
May 14, 2018: Planta
https://www.readbyqxmd.com/read/29757434/hdac3-selective-inhibition-activates-brown-and-beige-fat-through-prdm16
#9
Jiling Liao, Juan Jiang, Heejin Jun, Xiaona Qiao, Margo P Emont, Dong-Il Kim, Jun Wu
It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte specific Hdac3 deletions have presented inconsistent results. In this study, we observed that HDAC3 protein levels were lower in brown fat compared to that of inguinal subcutaneous adipose tissue, and were decreased in both fat depots upon cold exposure. PRDM16 physically interacted with HDAC3, and treatment with HDAC3-selective inhibitor RGFP966 induced thermogenic gene expression in murine and human fat cultures...
May 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29755482/silicon-improves-chilling-tolerance-during-early-growth-of-maize-by-effects-on-micronutrient-homeostasis-and-hormonal-balances
#10
Narges Moradtalab, Markus Weinmann, Frank Walker, Birgit Höglinger, Uwe Ludewig, Guenter Neumann
Low soil temperature in spring is a major constraint for the cultivation of tropical and subtropical crops in temperate climates, associated with inhibition of root growth and activity, affecting early growth and frequently plant performance and final yield. This study was initiated to investigate the physiological base of cold-protective effects induced by supplementation with silicon (Si), widely recommended as a stress-protective mineral nutrient. Maize was used as a cold-sensitive model plant, exposed to chilling stress and low root-zone temperature (RZT) during early growth in a lab to field approach...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29755411/time-of-day-effects-on-metabolic-and-clock-related-adjustments-to-cold
#11
Frederico Sander Mansur Machado, Zhi Zhang, Yan Su, Paul de Goede, Remi Jansen, Ewout Foppen, Cândido Celso Coimbra, Andries Kalsbeek
Background: Daily cyclic changes in environmental conditions are key signals for anticipatory and adaptive adjustments of most living species, including mammals. Lower ambient temperature stimulates the thermogenic activity of brown adipose tissue (BAT) and skeletal muscle. Given that the molecular components of the endogenous biological clock interact with thermal and metabolic mechanisms directly involved in the defense of body temperature, the present study evaluated the differential homeostatic responses to a cold stimulus at distinct time-windows of the light/dark-cycle...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29755363/an-evidence-based-approach-for-choosing-post-exercise-recovery-techniques-to-reduce-markers-of-muscle-damage-soreness-fatigue-and-inflammation-a-systematic-review-with-meta-analysis
#12
Olivier Dupuy, Wafa Douzi, Dimitri Theurot, Laurent Bosquet, Benoit Dugué
Introduction: The aim of the present work was to perform a meta-analysis evaluating the impact of recovery techniques on delayed onset muscle soreness (DOMS), perceived fatigue, muscle damage, and inflammatory markers after physical exercise. Method: Three databases including PubMed, Embase , and Web-of-Science were searched using the following terms: ("recovery" or "active recovery" or "cooling" or "massage" or "compression garment" or "electrostimulation" or "stretching" or "immersion" or "cryotherapy") and ("DOMS" or "perceived fatigue" or "CK" or "CRP" or "IL-6") and ("after exercise" or "post-exercise") for randomized controlled trials, crossover trials, and repeated-measure studies...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29751949/platelet-storage-lesions-what-more-do-we-know-now
#13
REVIEW
Monica Suet Ying Ng, John-Paul Tung, John Francis Fraser
Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate availability and safety are limited by the development of platelet storage lesions (PSLs) and risk of bacterial contamination. Platelet storage lesions are a series of biochemical, structural, and functional changes that occur from blood collection to transfusion. Understanding of PSLs is key for devising interventions that prolong PC shelf life to improve PC access and wastage...
April 17, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29751060/expression-and-deletion-analyses-of-cspe-encoding-cold-shock-protein-e-in-acinetobacter-oleivorans-dr1
#14
Jisun Kim, Sunhee Ha, Woojun Park
Six genes encoding cold-shock-like proteins, including cspE, are contained within the genome of Acinetobacter oleivorans DR1. All six genes are similar in size as well as amino acid identity, but appear to be differentially regulated under stressful conditions. Four of these genes (cspA, cspB, cspC and cspE) were functionally important during cold shock because of their gradual upregulation during a temperature decrease under our assay conditions. cspE also showed higher expression during alkane degradation and antibiotic exposure...
May 8, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29750781/metabolic-benefits-of-inhibition-of-p38%C3%AE-in-white-adipose-tissue-in-obesity
#15
Shengjie Zhang, Hongchao Cao, Yan Li, Yanyan Jing, Shengnan Liu, Cheng Ye, Hui Wang, Shuxian Yu, Chengyuan Peng, Lijian Hui, Yu-Cheng Wang, Haibing Zhang, Feifan Guo, Qiwei Zhai, Hui Wang, Ruimin Huang, Ling Zhang, Jingjing Jiang, Wei Liu, Hao Ying
p38 has long been known as a central mediator of protein kinase A (PKA) signaling in brown adipocytes, which positively regulate the transcription of uncoupling protein 1 (UCP-1). However, the physiological role of p38 in adipose tissues, especially the white adipose tissue (WAT), is largely unknown. Here, we show that mice lacking p38α in adipose tissues display a lean phenotype, improved metabolism, and resistance to diet-induced obesity. Surprisingly, ablation of p38α causes minimal effects on brown adipose tissue (BAT) in adult mice, as evident from undetectable changes in UCP-1 expression, mitochondrial function, body temperature (BT), and energy expenditure...
May 11, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29750280/can-sensation-of-cold-hands-predict-raynaud-s-phenomenon-or-paraesthesia
#16
D Carlsson, J Wahlström, L Burström, M Hagberg, R Lundström, H Pettersson, T Nilsson
Background: Raynaud's phenomenon and neurosensory symptoms are common after hand-arm vibration exposure. Knowledge of early signs of vibration injuries is needed. Aims: To investigate the risk of developing Raynaud's phenomenon and paraesthesia in relation to sensation of cold hands in a cohort of male employees at an engineering plant. Methods: We followed a cohort of male manual and office workers at an engineering plant in Sweden for 21 years...
May 10, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29750246/comparison-of-water-relation-in-two-powderpost-beetles-relative-to-body-size-and-ontogenetic-and-behavioral-traits
#17
Lee-Jin Bong, Kok-Boon Neoh, Tsuyoshi Yoshimura
Heterobostrychus aequalis (Waterhouse) (Coleoptera: Bostrychidae) and Lyctus africanus Lesne (Coleoptera: Lyctidae) are distributed mainly in tropical regions. The primary mechanism allowing these beetles to survive in cold and arid habitats beyond the native tropical region is a reduced water loss rate. This study investigated the water relations of these two beetles in relation to their size, ontogenetic traits, and behavioral characteristics to determine how they can survive in desiccated wood. H. aequalis and L...
May 10, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29748912/investigating-changes-in-mortality-attributable-to-heat-and-cold-in-stockholm-sweden
#18
Daniel Oudin Åström, Kristie L Ebi, Ana Maria Vicedo-Cabrera, Antonio Gasparrini
Projections of temperature-related mortality rely upon exposure-response relationships using recent data. Analyzing long historical data and trends may extend knowledge of past and present impacts that may provide additional insight and improve future scenarios. We collected daily mean temperatures and daily all-cause mortality for the period 1901-2013 for Stockholm County, Sweden, and calculated the total attributable fraction of mortality due to non-optimal temperatures and quantified the contribution of cold and heat...
May 11, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29747426/rapid-cold-hardening-confers-a-transient-increase-in-low-temperature-survival-in-diapausing-chilo-suppressalis-larvae
#19
Guangping Yang, Jihui Wen, Yongqiang Han, Maolin Hou
The striped stem borer, Chilo suppressalis (Walker), overwinters as a diapausing larva. The diapausing larvae were tested for a rapid cold hardening (RCH) response and its role in the insect&rsquo;s survival of sub-zero temperatures. When laboratory-reared diapausing larvae were transferred directly from the rearing temperature of 25 &deg;C to &minus;14 &deg;C and maintained there for 2 h, 21% survived. Acclimation of diapausing larvae for 4 h at 5 &deg;C before their exposure for 2 h to &minus;14 &deg;C increased survival to approximately 41%, indicating an RCH response...
May 9, 2018: Insects
https://www.readbyqxmd.com/read/29746664/translational-control-plays-an-important-role-in-the-adaptive-heat-shock-response-of-streptomyces-coelicolor
#20
Giselda Bucca, Radhika Pothi, Andrew Hesketh, Carla Möller-Levet, David A Hodgson, Emma E Laing, Graham R Stewart, Colin P Smith
Stress-induced adaptations require multiple levels of regulation in all organisms to repair cellular damage. In the present study we evaluated the genome-wide transcriptional and translational changes following heat stress exposure in the soil-dwelling model actinomycete bacterium, Streptomyces coelicolor. The combined analysis revealed an unprecedented level of translational control of gene expression, deduced through polysome profiling, in addition to transcriptional changes. Our data show little correlation between the transcriptome and 'translatome'; while an obvious downward trend in genome wide transcription was observed, polysome associated transcripts following heat-shock showed an opposite upward trend...
May 9, 2018: Nucleic Acids Research
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