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https://www.readbyqxmd.com/read/29344396/adversity-of-prolonged-extreme-cold-exposure-among-adult-clients-diagnosed-with-coronary-artery-diseases-a-primer-for-recommending-community-health-nursing-intervention
#1
Eladio Martin S Gumabay, Raquel C Ramirez, Judy Mae M Dimaya, Mae M Beltran
Aim: This research study explored the lived experiences of adults diagnosed with Coronary Artery Disease (CAD) when exposed to a prolonged period of extreme cold. Design: This research study utilized descriptive qualitative research design. Methods: Face-to-face interview sessions with audio recording were conducted. There were 30 informants who participated in the study. Descriptive phenomenology with Colaizzi's method of data analysis was used...
January 2018: Nursing Open
https://www.readbyqxmd.com/read/29343895/why-borrow-from-peter-when-paul-can-afford-it-reverse-homodigital-artery-flap-for-fingertip-reconstruction
#2
Narayanamurthy Sundaramurthy, Surya Rao Rao Venkata Mahipathy, Alagar Raja Durairaj
Background: Fingertip injuries that are complicated by pulp loss, bone or tendon exposure will need a flap cover. Cross finger flap is commonly used to cover such defects. However, patients are apprehensive about injuring the uninjured finger as a donor site. Reverse homodigital artery flap (RHAF) can provide reliable vascularised cover to such defects. Aims: This study aims to assess the functional and aesthetic outcomes along with the patient satisfaction of RHAFs done for fingertip defects...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29341194/generation-of-red-drum-sciaenops-ocellatus-hematology-reference-intervals-with-a-focus-on-identified-outliers
#3
Kendal E Harr, Kristina Deak, Steven A Murawski, Drury R Reavill, Ryan A Takeshita
BACKGROUND: The Deepwater Horizon (DWH) oil spill in 2010 released millions of barrels of crude oil into the northern Gulf of Mexico, exposing numerous species of animals to the toxic components of oil. A comprehensive assessment of morbidity and mortality caused by DWH oil exposure was undertaken by the DWH Natural Resource Damage Trustees to characterize ecosystem damages. OBJECTIVES: This study aimed to characterize normal hematologic RIs in red drum fish with blood cell descriptions, and to demonstrate the importance of identifying and removing outliers when generating RI...
January 17, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29339725/tgr5-signalling-promotes-mitochondrial-fission-and-beige-remodelling-of-white-adipose-tissue
#4
Laura A Velazquez-Villegas, Alessia Perino, Vera Lemos, Marika Zietak, Mitsunori Nomura, Thijs Willem Hendrik Pols, Kristina Schoonjans
Remodelling of energy storing white fat into energy expending beige fat could be a promising strategy to reduce adiposity. Here, we show that the bile acid-responsive membrane receptor TGR5 mediates beiging of the subcutaneous white adipose tissue (scWAT) under multiple environmental cues including cold exposure and prolonged high-fat diet feeding. Moreover, administration of TGR5-selective bile acid mimetics to thermoneutral housed mice leads to the appearance of beige adipocyte markers and increases mitochondrial content in the scWAT of Tgr5 +/+ mice but not in their Tgr5 -/- littermates...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29339666/preventive-cold-acclimation-augments-the-reparative-function-of-endothelial-progenitor-cells-in-mice
#5
Cheng Peng, Li-Ping Wang, Xia Tao, Xiao-Hui Dong, Chun-Fang Xu, Yu Jiang, Chun-Long Liu, Hui-Fang Ma, Chuan Zhang, Alex F Chen, He-Hui Xie
BACKGROUND/AIMS: Chronic cold exposure may increase energy expenditure and contribute to counteracting obesity, an important risk factor for cerebrocardiovascular diseases. This study sought to evaluate whether preventive cold acclimation before ischemia onset might be a promising option for preventing cerebral ischemic injury. METHODS: After a 14-day cold acclimation period, young and aged mice were subjected to permanent cerebral ischemia, and histological analyses and behavioral tests were performed...
January 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29337646/stability-of-an-aluminum-salt-adjuvanted-protein-d-conjugated-pneumococcal-vaccine-after-exposure-to-subzero-temperatures
#6
Juliette Fortpied, Florence Wauters, Christelle Rochart, Philippe Hermand, Bernard Hoet, Nicolas Moniotte, Ivo Vojtek
Accidental exposure of a vaccine containing an aluminum-salt adjuvant to temperatures below 0°C in the cold chain can lead to freeze damage. Our study evaluated the potential for freeze damage in a licensed aluminum-salt-containing protein-D-conjugated pneumococcal vaccine (PHiD-CV; Synflorix, GSK) in conditions that included static storage, single subzero-temperature excursions, and simulated air-freight transportation. Several parameters were assessed including freezing at subzero temperatures, aluminum-salt-particle size, antigen integrity and immunogenicity in the mouse...
January 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29334412/stallion-semen-quality-depends-on-mhc-matching-to-teaser-mare
#7
E Jeannerat, E Marti, C Berney, F Janett, H Bollwein, H Sieme, D Burger, C Wedekind
The major histocompatibility complex (MHC) has repeatedly been found to influence mate choice of vertebrates, with MHC-dissimilar mates typically being preferred over MHC-similar mates. We used horses (Equus caballus) to test whether MHC matching also affects male investment into ejaculates after short exposure to a female. Semen characteristics varied much among stallions. Controlling for this variance with a full-factorial within-subject experimental design, we found that a short exposure to an MHC-dissimilar mare enhanced male plasma testosterone and led to ejaculates with elevated sperm numbers as compared to exposure to an MHC-similar mare...
January 15, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29326420/fasting-and-glucose-induced-thermogenesis-in-response-to-three-ambient-temperatures-a-randomized-crossover-trial-in-the-metabolic-syndrome
#8
K Pathak, R J Woodman, A P James, M J Soares
BACKGROUND/OBJECTIVES: Cold exposure increases thermogenesis and could improve insulin sensitivity. We hypothesized a blunted response in the metabolic syndrome (MetS). SUBJECTS/METHODS: Twenty older adults 59 ± 10.4 years (with MetS, MetS+, n = 9; without MetS, MetS-, n = 11) completed a randomized crossover design of 3.5 h exposures to 20, 25 and 27 °C on three visits. After an hour's rest at the desired temperature, resting metabolic rate (RMR), respiratory quotient (RQ), forearm to fingertip gradients (FFG), and in the ear temperature (IET) were measured over 30 min...
January 11, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29322345/freshwater-shrimps-macrobrachium-depressimanum-and-macrobrachium-jelskii-as-biomonitors-of-hg-availability-in-the-madeira-river-basin-western-amazon
#9
R C F Galvão, I B B Holanda, D P De Carvalho, R Almeida, C M M Souza, L D Lacerda, W R Bastos
Total mercury (THg) concentrations measured in two freshwater shrimp species (Macrobrachium depressimanum and Macrobrachium jelskii) showed a relationship with the location of artisanal and small-scale gold mining (ASGM) from the Madeira River Basin, Western Amazon. Between August 2009 and May 2010, 212 shrimp samples were collected in the confluence of the Madeira River with three of its tributaries (Western Amazon). THg concentration was quantified in the exoskeleton, hepatopancreas and muscle tissue of the shrimps by cold vapor atomic absorption spectrophotometry...
January 10, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29314414/an-ortholog-of-curly-leaf-enhancer-of-zeste-like-1-is-required-for-proper-flowering-in-brachypodium-distachyon
#10
Aaron Lomax, Daniel P Woods, Yinxin Dong, Frédéric Bouché, Ying Rong, Kevin S Mayer, Xuehua Zhong, Richard M Amasino
Many plants require prolonged cold exposure to acquire the competence to flower. The process by which cold exposure results in competence is known as vernalization. In Arabidopsis thaliana, vernalization leads to the stable repression of the floral repressor FLOWERING LOCUS C via chromatin modification including an increase of trimethylation on lysine 27 of histone H3 (H3K27me3) by Polycomb Repressive Complex 2 (PRC2). Vernalization in pooids is associated with the stable induction of a floral promoter, VERNALIZATION 1...
January 4, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29310935/degradation-of-brown-adipocyte-purine-nucleotides-regulates-uncoupling-protein-1-activity
#11
Tobias Fromme, Karin Kleigrewe, Andreas Dunkel, Angelika Retzler, Yongguo Li, Stefanie Maurer, Natascha Fischer, Rolf Diezko, Timo Kanzleiter, Verena Hirschberg, Thomas Hofmann, Martin Klingenspor
OBJECTIVE: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition. We measured the cellular concentration and the release of purine nucleotide metabolites to uncover a possible role of purine nucleotide degradation in uncoupling protein 1 activation. METHODS: With mass spectrometry, purine nucleotide metabolites were quantified in cellular homogenates and supernatants of cultured primary brown adipocytes...
December 26, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29304467/vertical-variation-of-pm2-5-mass-and-chemical-composition-particle-size-distribution-no2-and-btex-at-a-high-rise-building
#12
Stefano Zauli Sajani, Stefano Marchesi, Arianna Trentini, Dimitri Bacco, Claudia Zigola, Sabrina Rovelli, Isabella Ricciardelli, Claudio Maccone, Paolo Lauriola, Domenico Maria Cavallo, Vanes Poluzzi, Andrea Cattaneo, Roy M Harrison
Substantial efforts have been made in recent years to investigate the horizontal variability of air pollutants at regional and urban scales and epidemiological studies have taken advantage of resulting improvements in exposure assessment. On the contrary, only a few studies have investigated the vertical variability and their results are not consistent. In this study, a field experiment has been conducted to evaluate the variation of concentrations of different particle metrics and gaseous pollutants on the basis of floor height at a high rise building...
January 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29301697/cooling-rate-and-starvation-affect-supercooling-point-and-cold-tolerance-of-the-khapra-beetle-trogoderma-granarium-everts-fourth-instar-larvae-coleoptera-dermestidae
#13
M Mohammadzadeh, H Izadi
Trogoderma granarium Everts (Coleoptera: Dermestidae) is an important insect pest of stored products. In this study, the survival strategies of T. granarium fourth instar larvae were investigated at different sub-zero temperatures following different cooling rates, acclimation to different relative humidity (RH) and different starvation times. Our results show that larvae of T. granarium are freeze-intolerant. There was a strong link between cooling rates and supercooling point, which means the slower the decrease in temperature, the lower the supercooling point...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29298420/the-apolipoprotein-m-s1p-axis-controls-triglyceride-metabolism-and-brown-fat-activity
#14
Christina Christoffersen, Christine K Federspiel, Anna Borup, Pernille M Christensen, Andreas N Madsen, Markus Heine, Carsten H Nielsen, Andreas Kjaer, Birgitte Holst, Joerg Heeren, Lars B Nielsen
Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29297123/the-abscisic-acid-influence-on-the-gene-expression-of-pro-and-anti-apoptotic-proteins-in-the-leaves-of-cucumber-plants-at-low-temperatures
#15
V V Talanova, A F Titov, N S Repkina, A A Ignatenko
We studied the effect of abscisic acid (ABA) on the expression of genes encoding the functional homologues of proapoptotic (CsBAX) and antiapoptotic (CsBI-1) proteins in cucumber leaves at low temperatures. The exposure to a hardening temperature of 12°C caused a slight increase in the level of CsBAX gene transcript and a sharp increase in the CsBI-1 gene transcript. At a damaging temperature of 4°C, the content of the CsBAX gene mRNA significantly increased, whereas the content of the CsBI-1 gene mRNA remained virtually unchanged...
November 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29288825/inhibitory-effects-of-aconiti-lateralis-radix-preparata-on-chronic-intermittent-cold-induced-inflammation-in-the-mouse-hypothalamus
#16
Wonnam Kim, Wonil Lee, Jin Gyu Choi, In Gyoung Ju, Yun-Kyung Kim, Tae Hee Lee, Myung Sook Oh
ETHNOPHARMACOLOGICAL RELEVANCE: Aconiti Lateralis Radix Preparata (AR) is the most frequently used herb to generate heat and treat symptoms associated with coldness in Asia. AIMS OF THE STUDY: The hypothalamus is one of the master regulators to maintain constant core body temperature. Chronic exposure to cold stress disturbs homeostatic regulation, gradually resulting in hypothalamic inflammation. This study investigate the effects of AR, on the chronic intermittent cold (CIC)-induced release of pro-inflammatory signaling molecules in the mouse hypothalamus...
December 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29287835/sugar-compartmentation-as-an-environmental-stress-adaptation-strategy-in-plants
#17
REVIEW
Kohji Yamada, Yuriko Osakabe
The sessile nature of plants has driven their evolution to cope flexibly with ever-changing surrounding environments. The development of stress tolerance traits is complex, and a broad range of cellular processes are involved. Recent studies have revealed that sugar transporters contribute to environmental stress tolerance in plants, suggesting that sugar flow is dynamically fluctuated towards optimization of cellular conditions in adverse environments. Here, we highlight sugar compartmentation mediated by sugar transporters as an adaptation strategy against biotic and abiotic stresses...
December 26, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29286416/immuno-fluorescent-labeling-of-microtubules-and-centrosomal-proteins-in-ex-vivo-intestinal-tissue-and-3d-in-vitro-intestinal-organoids
#18
Deborah A Goldspink, Zoe J Matthews, Elizabeth K Lund, Tom Wileman, Mette M Mogensen
The advent of 3D in vitro organoids that mimic the in vivo tissue architecture and morphogenesis has greatly advanced the ability to study key biological questions in cell and developmental biology. In addition, organoids together with recent technical advances in gene editing and viral gene delivery promises to advance medical research and development of new drugs for treatment of diseases. Organoids grown in vitro in basement matrix provide powerful model systems for studying the behavior and function of various proteins and are well suited for live-imaging of fluorescent-tagged proteins...
December 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29276803/projections-of-temperature-related-excess-mortality-under-climate-change-scenarios
#19
Antonio Gasparrini, Yuming Guo, Francesco Sera, Ana Maria Vicedo-Cabrera, Veronika Huber, Shilu Tong, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Eric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jan Kyselý, Aleš Urban, Jouni J K Jaakkola, Niilo R I Ryti, Mathilde Pascal, Patrick G Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Yasushi Honda, Magali Hurtado-Diaz, Julio Cesar Cruz, Xerxes Seposo, Ho Kim, Aurelio Tobias, Carmen Iñiguez, Bertil Forsberg, Daniel Oudin Åström, Martina S Ragettli, Yue Leon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel Schwartz, Michelle L Bell, Tran Ngoc Dang, Dung Do Van, Clare Heaviside, Sotiris Vardoulakis, Shakoor Hajat, Andy Haines, Ben Armstrong
Background: Climate change can directly affect human health by varying exposure to non-optimal outdoor temperature. However, evidence on this direct impact at a global scale is limited, mainly due to issues in modelling and projecting complex and highly heterogeneous epidemiological relationships across different populations and climates. Methods: We collected observed daily time series of mean temperature and mortality counts for all causes or non-external causes only, in periods ranging from Jan 1, 1984, to Dec 31, 2015, from various locations across the globe through the Multi-Country Multi-City Collaborative Research Network...
December 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29274128/the-metabolic-under-groundwork-of-the-lily-bulb-towards-sprouting
#20
Silit Lazare, Asdrubal Burgos, Yariv Brotman, Michele Zaccai
Large bulbs of Lilium longiflorum have an obligatory cold requirement to flower. Bulb cooling is widely used to induce and accelerate flowering. However, in-depth investigations of the effect of bulb cooling on major landmarks of plant development are lacking. It has been demonstrated that low temperature induces carbohydrate degradation, yet integrative studies on metabolic changes occurring in the bulb are not available. We detected that cold exposure mainly hastened bulb sprouting, rather than floral transition or blooming...
December 22, 2017: Physiologia Plantarum
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