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https://www.readbyqxmd.com/read/28726752/health-impacts-of-climate-change-induced-subzero-temperature-fires
#1
Maria-Monika Metallinou, Torgrim Log
General fire risk and the special risk related to cold climate cellulosic drying processes are outlined. Four recent subzero temperatures fires are studied with respect to health impacts: a wooden village fire, a single wood structure fire, a wildland urban interface (WUI) fire and a huge wildland fire. The health impacts range from stress related to loss of jobs, psychological effects of lost possessions, exposure to smoke and heat as well as immediate, or delayed, loss of lives. These four fires resulted in 32 fatalities, 385 persons hospitalized for shorter or longer periods, 104 structures lost and 1015 km² of wildland burned north of, and just south of, the Arctic Circle...
July 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28723567/cold-inducible-sirt6-regulates-thermogenesis-of-brown-and-beige-fat
#2
Lu Yao, Xiaona Cui, Qi Chen, Xiaoying Yang, Fude Fang, Jun Zhang, Guoqing Liu, Wanzhu Jin, Yongsheng Chang
Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O2) consumption, obesity, decreased core body temperature, and cold sensitivity. Fat SIRT6-deleted mice exhibit increased blood glucose levels, severe insulin resistance, and hepatic steatosis...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28722694/early-life-vincristine-exposure-evokes-mechanical-pain-hypersensitivity-in-the-developing-rat
#3
Katie A Schappacher, Lauren Styczynski, Mark L Baccei
Vincristine (VNC) is commonly used to treat pediatric cancers, including the most prevalent childhood malignancy, acute lymphoblastic leukemia. Although clinical evidence suggests that VNC causes peripheral neuropathy in children, the degree to which pediatric chemotherapeutic regimens influence pain sensitivity throughout life remains unclear, in part because of the lack of an established animal model of chemotherapy-induced neuropathic pain during early life. Therefore, this study investigated the effects of VNC exposure between postnatal days (P) 11 and 21 on mechanical and thermal pain sensitivity in the developing rat...
May 30, 2017: Pain
https://www.readbyqxmd.com/read/28722639/human-cases-of-tularemia-in-armenia-1996-2012
#4
Syuzanna Melikjanyan, Karo Palayan, Artavazd Vanyan, Lilit Avetisyan, Nune Bakunts, Marine Kotanyan, Marta Guerra
A retrospective analysis was conducted of human cases and outbreaks of tularemia in the Republic of Armenia from 1996 to 2012 utilizing Geographic Information System software. A total of 266 human cases of tularemia were recorded in Armenia from 1996 to 2012, with yearly incidence ranging from 0 to 5.5 cases per 100,000 people. Cases predominantly affected the male population (62.8%), 11-20 year age group (37.2%), agricultural workers (49.6%), and persons residing in rural areas (93.6%). In 2003, a waterborne outbreak involving 158 cases occurred in Kotayk Marz, and in 2007, a foodborne outbreak with 17 cases occurred in Gegharkunik Marz, attributed to exposure of food products to contaminated hay...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28716420/characterization-of-bdcbf-genes-and-genome-wide-transcriptome-profiling-of-bdcbf3-dependent-and-independent-cold-stress-responses-in-brachypodium-distachyon
#5
Jingjie Hao, Jinliang Yang, Jiangli Dong, Shui-Zhang Fei
Freezing stress substantially reduces crop yields and limits plant distribution. The identification of genes critical for cold acclimation is thus of great importance. C-repeat binding factors (CBFs) are transcription factors that play key regulatory roles in the cold acclimation process, which dramatically increases freezing tolerance in plants. We report here that B. distachyon can successfully cold acclimate and we identified a CBF gene family consisting of eight genes in a tandem array and are designated as BdCBF1-8...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28715885/the-effects-of-exercise-and-cold-exposure-on-mitochondrial-biogenesis-in-skeletal-muscle-and-white-adipose-tissue
#6
Nana Chung, Jonghoon Park, Kiwon Lim
PURPOSE: The purpose of this study was to determine whether exercise or/and cold exposure regulate mitochondria biogenesis-related gene expression in soleus and inguinal adipose tissue of mice. METHODS: Forty ICR 5-week old male mice were divided into four groups: thermoneutrality-untrained (23 ± 1 °C in room temperature, n=10), cold-water immersion (24 ± 1 °C, n=10), exercise in neutral temperature (34 ± 1 °C, n=10), and exercise in cold temperature (24 ± 1 °C, n=10)...
June 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28714258/renal-neuroendocrine-control-of-desiccation-and-cold-tolerance-by-drosophila-suzukii
#7
Selim Terhzaz, Lucy Alford, Joseph G C Yeoh, Richard Marley, Anthony J Dornan, Julian A T Dow, Shireen A Davies
BACKGROUND: Neuropeptides are central to the regulation of physiological, and behavioural processes in insects, directly impacting cold and desiccation survival. However, little is known about the control mechanisms governing these responses in D. suzukii. The close phylogenetic relationship of D. suzukii with D. melanogaster allows, through genomic and functional studies, an insight into the mechanisms directing stress tolerance in D. suzukii. RESULTS: Capa, Leucokinin, DH44 and DH31 neuropeptides demonstrate a high level of conservation between D...
July 17, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28707371/individuals-with-sickle-cell-disease-have-a-significantly-greater-vasoconstriction-response-to-thermal-pain-than-controls-and-have-significant-vasoconstriction-in-response-to-anticipation-of-pain
#8
Maha Khaleel, Mammen Puliyel, Payal Shah, John Sunwoo, Roberta M Kato, Patjanaporn Chalacheva, Wanwara Thuptimdang, Jon Detterich, John C Wood, Jennie Tsao, Lonnie Zeltzer, Richard Sposto, Michael C K Khoo, Thomas D Coates
The painful vaso-occlusive crises (VOC) that characterize sickle cell disease (SCD) progress over hours from the asymptomatic steady-state. SCD patients report that VOC can be triggered by stress, cold exposure and pain itself. We anticipated that pain could cause neural-mediated vasoconstriction, decreasing regional blood flow and promoting entrapment of sickle cells in the microvasculature. Therefore, we measured microvascular blood flow in the fingers of both hands using plethysmography and laser-Doppler flowmetry while applying a series of painful thermal stimuli on the right forearm in 23 SCD patients and 25 controls...
July 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28705828/crispr-induced-null-alleles-show-that-frost-protects-drosophila-melanogaster-reproduction-after-cold-exposure
#9
Claire E Newman, Jantina Toxopeus, Hiroko Udaka, Soohyun Ahn, David M Martynowicz, Steffen P Graether, Brent J Sinclair, Anthony Percival-Smith
The ability to survive and reproduce after cold exposure is important in all kingdoms of life. However, even in a sophisticated genetic model system like Drosophila melanogaster, few genes have been identified as functioning in cold tolerance. The accumulation of the Frost (Fst) gene transcript increases after cold exposure, making it a good candidate for a gene that has a role in cold tolerance. However, despite extensive RNAi knockdown analysis, no role in cold tolerance has been assigned to Fst CRISPR is an effective technique for completely knocking down genes, and less likely to produce off-target effects than GAL4-UAS RNAi systems...
July 13, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28704795/endocan-concentrations-in-postmortem-serum-vitreous-humor-and-urine-in-victims-of-lethal-hypothermia
#10
Emilienne Descloux, Marc Augsburger, Grzegorz Teresiński, Petr Hejna, Eric Grouzmann, Maria Pia Scarpelli, Tania Hervet, Cristian Palmiere
Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells...
July 4, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28702327/loss-of-adamts5-enhances-brown-adipose-tissue-mass-and-promotes-browning-of-white-adipose-tissue-via-creb-signaling
#11
Dries Bauters, Mathias Cobbaut, Lotte Geys, Johan Van Lint, Bianca Hemmeryckx, H Roger Lijnen
OBJECTIVE: A potential strategy to treat obesity - and the associated metabolic consequences - is to increase energy expenditure. This could be achieved by stimulating thermogenesis through activation of brown adipose tissue (BAT) and/or the induction of browning of white adipose tissue (WAT). Over the last years, it has become clear that several metalloproteinases play an important role in adipocyte biology. Here, we investigated the potential role of ADAMTS5. METHODS: Mice deficient in ADAMTS5 (Adamts5(-/-)) and wild-type (Adamts5(+/+)) littermates were kept on a standard of Western-type diet for 15 weeks...
July 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28700518/agility-and-vertical-jump-performances-are-impacted-by-acute-cool-exposure
#12
Lara A Carlson, Cara Fowler, Michael A Lawrence
Outdoor sports teams may be exposed to acute cold stress during competition, which may affect performance. Limited research has explored the effects of cold exposure on athletic components. The purpose of this study was to examine the effects of an acute whole-body cool exposure on pro-agility, vertical jump, and sprint performances. Eleven lightly clothed (∼0.3 clo) and not cold acclimatized volunteers (10/1 women/men: age 20.5 ± 0.5 y; height 1.65 ± 0.09 m; mass 63.3 ± 8.9 kg; body fat 21.3 ± 7.6%) completed performance tests in both thermoneutral (17...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28700271/lsd1-a-metabolic-sensor-of-environment-requirements-that-prevents-adipose-tissue-from-aging
#13
Delphine Duteil, Milica Tosic, Roland Schüle
Understanding development and maintenance of beige adipocytes provide exciting insights in establishing novel therapies against obesity and obesity-associated disorders. Lysine-specific demethylase 1 (Lsd1) is an epigenetic eraser required for differentiation and function of adipocytes. Lsd1 is involved in early commitment of preadipocytes, but dispensable for terminal differentiation of white adipose tissue (WAT). In mature adipocytes, Lsd1 responds to different environmental stimuli to alter metabolic function and enable proper thermogenic and oxidative response...
June 26, 2017: Adipocyte
https://www.readbyqxmd.com/read/28697826/-risk-factors-for-congenital-heart-disease-in-chinese-neonates-a-meta-analysis
#14
Yi Liu, Bei Zhu, Lin Zhuo, Ming-Yu He, Yang Xu, Tong-Tong Wang, Qing-Qing Cai, Bin Hu, Ji-Cheng Xu, Wen-Hui Zhang
OBJECTIVE: To investigate the major risk factors for congenital heart disease (CHD) in Chinese neonates and to provide a reference for the prevention of CHD. METHODS: A literature search was performed to collect the case-control studies on the risk factors for CHD in Chinese neonates published in 2001-2016. The relevant data were extracted accordingly. The quality of included studies was assessed by Newcastle-Ottawa Scale. Sensitivity analysis was conducted using different models to analyze the same data...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28696940/multiple-selective-events-at-the-prdm16-functional-pathway-shaped-adaptation-of-western-european-populations-to-different-climate-conditions
#15
Andrea Quagliarello, Sara De Fanti, Cristina Giuliani, Paolo Abondio, Patrizia Serventi, Stefania Sarno, Marco Sazzini, Donata Luiselli
Several studies highlighted the role of climate in shaping many human evolutionary processes. This occurred even in relatively recent times, having affected various human phenotypic traits, among which metabolic processes that orchestrate absorption and accumulation of substances to maintain energy homeostasis, that is critical for the survival of individuals in high energy-expenditure environments. To date, most researches have focalized on detection of climatic influence on SNPs' frequency in populations exposed to extreme environmental conditions or by comparing variation patterns between populations from different continents...
July 10, 2017: Journal of Anthropological Sciences, Rivista di Antropologia: JASS
https://www.readbyqxmd.com/read/28696252/thermoneutrality-but-not-ucp1-deficiency-suppresses-monocyte-mobilization-into-blood
#16
Jesse W Williams, Andrew F Elvington, Stoyan Ivanov, Skyler Kessler, Hannah Luehmann, Osamu Baba, Brian T Saunders, Ki-Wook Kim, Michael W Johnson, Clarissa S Craft, Jae-Hoon Choi, Mary G Sorci-Thomas, Bernd H Zinselmeyer, Jonathan R Brestoff, Yongjian Liu, Gwendalyn J Randolph
Rationale: Ambient temperature is a risk factor for cardiovascular disease. Cold weather increases cardiovascular events, but paradoxically, cold exposure is metabolically protective due to UCP1-dependent thermogenesis. Objective: We sought to determine the differential effects of ambient environmental temperature challenge and UCP1 activation in relation to cardiovascular disease progression. Methods and Results: Using mouse models of atherosclerosis housed at three different ambient temperatures, we observed that cold temperature enhanced while thermoneutral housing temperature inhibited atherosclerotic plaque growth, as did deficiency in UCP1...
July 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/28694818/insights-into-the-molecular-events-that-regulate-heat-induced-chilling-tolerance-in-citrus-fruits
#17
María T Lafuente, Beatriz Establés-Ortíz, Luis González-Candelas
Low non-freezing temperature may cause chilling injury (CI), which is responsible for external quality deterioration in many chilling-sensitive horticultural crops. Exposure of chilling-sensitive citrus cultivars to non-lethal high-temperature conditioning may increase their chilling tolerance. Very little information is available about the molecular events involved in such tolerance. In this work, the molecular events associated with the low temperature tolerance induced by heating Fortune mandarin, which is very sensitive to chilling, for 3 days at 37°C prior to cold storage is presented...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28694447/impacts-of-early-life-stress-on-the-methylome-and-transcriptome-of-atlantic-salmon
#18
Hooman K Moghadam, Hanne Johnsen, Nicholas Robinson, Øivind Andersen, Even H Jørgensen, Helge K Johnsen, Vegar J Bæhr, Helge Tveiten
Exposure to environmental stressors during early-life stages can change the rate and timing of various developmental processes. Epigenetic marks affecting transcriptional regulation can be altered by such environmental stimuli. To assess how stress might affect the methylome and transcriptome in salmon, fish were treated using cold-shock and air-exposure from the eye-stage until start-feeding. The fish were either stressed prior to hatching (E), post-hatching (PH), pre- and post-hatching (EPH) or not stressed (CO)...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692396/characterizing-the-effects-of-extreme-cold-using-real-time-syndromic-surveillance-ontario-canada-2010-2016
#19
Nancy VanStone, Adam van Dijk, Timothy Chisamore, Brian Mosley, Geoffrey Hall, Paul Belanger, Kieran Michael Moore
Morbidity and mortality from exposure to extreme cold highlight the need for meaningful temperature thresholds to activate public health alerts. We analyzed emergency department (ED) records for cold temperature-related visits collected by the Acute Care Enhanced Surveillance system-a syndromic surveillance system that captures data on ED visits from hospitals in Ontario-for geographic trends related to ambient winter temperature. We used 3 Early Aberration Reporting System algorithms of increasing sensitivity-C1, C2, and C3-to determine the temperature at which anomalous counts of cold temperature-related ED visits occurred in northern and southern Ontario from 2010 to 2016...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28692011/far-forward-diagnostics-in-toxic-industrial-chemical-and-material-exposure-scenarios-and-biomarker-identification
#20
Charles C Young, Danielle L Ippolito
: This study describes key technical solutions for detecting environmental toxicants and diagnosing adverse health effects in military operational settings as outlined at a symposium cosponsored by the Department of Defense and the Johns Hopkins University-Applied Physics Laboratory (October 27 to 28, 2015). Such technologies are urgently needed in order to provide critical decision-aid tools and prognostic assessment of potential clinical sequelae. This review summarizes the state-of-the-science on (1) prioritization of adverse health effects, (2) existing technologies and diagnostic tools available for use in theater, (3) challenges to advancing diagnostic tools far-forward, and (4) the potential utility of anchoring diagnostic tools to adverse outcome pathways...
July 6, 2017: Journal of Occupational and Environmental Medicine
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