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Antimicrobial Activity

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https://www.readbyqxmd.com/read/28532121/antimicrobial-activity-of-puffball-bovistella-radicata-and-separation-of-bioactive-compounds
#1
Yong Ye, Kun Liu, Qinghua Zeng, Qingmei Zeng
BACKGROUND: To test the antimicrobial activity of different extracts and fermentation broth from puffball(Bovistella radicata), the different extracts and fermentation broth of puffball were prepared, the active fraction was investigated by UPLC-UV-MS and semi-preparative chromatograph. RESULTS: Through zones of inhibition (ZOI) and minimum inhibitory concentrations (MIC) tests, the supernatant of fermentation possessed best antimicrobial activity in all extracts whose MIC value is 31...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28532120/ultra-small-silver-nanoparticles-induced-ros-activated-toll-pathway-against-staphylococcus-aureus-disease-in-silkworm-model
#2
Pala Rajasekharreddy, Pathipati Usha Rani, Saidulu Mattapally, Sanjay Kumar Banerjee
The present study investigated the therapeutic action of flavonoids loaded silver nanoparticles (FLV-Ag NPs) on a silkworm, Bombyx mori L., larvae infected by the S. aureus, where an in vivo model system was used. FLV-Ag NPs were synthesized using a Ricinus communis L. leaf extracted flavonoid mixture in various concentrations. The reduction reaction was performed under a simple sunlight exposure condition. In the reduction process, quercetin and kaempferol loadings were also found. They were confirmed by UV-visible, TEM, XRD, XPS, DLS and FTIR spectroscopic techniques...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532117/optimization-for-extracellular-biosynthesis-of-silver-nanoparticles-by-penicillium-aculeatum-su1-and-their-antimicrobial-activity-and-cytotoxic-effect-compared-with-silver-ions
#3
Liang Ma, Wei Su, Jian-Xin Liu, Xiao-Xi Zeng, Zhi Huang, Wen Li, Zheng-Chun Liu, Jian-Xin Tang
The present study addresses an eco-friendly and energy-saving method for extracellular biosynthesis of silver nanoparticles (AgNPs) using a cell free filtrate of the fungus strain Penicillium aculeatum Su1 as a reducing agent. Parametric optimization of the biosynthesis process demonstrated different effects on the size, distribution, yield, and synthesis rate of biosynthesized AgNPs. The transmission electron microscopy (TEM) measurements demonstrated that AgNPs were spherical or approximately spherical, with a size between 4 and 55nm...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532080/antibiotic-loaded-microspheres-as-antimicrobial-delivery-systems-for-medical-applications
#4
J Szczeblinska, K Fijalkowski, J Kohn, M El Fray
In this paper, we present the preparation and antibiotic loading of polymeric microspheres, composed of copolymers derived from fatty acid/amino acid components, as new polymeric platforms for antibiotic delivery systems. New polymeric materials were used to prepare microspheres with and without immobilized model antibiotics (streptomycin, chloramphenicol and amphotericin B) by a W/O/W double-emulsion/solvent evaporation method, in which chloroform and poly(vinyl alcohol) are used as the solvent and emulsifier, respectively...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532029/surfactin-loaded-polyvinyl-alcohol-pva-nanofibers-alters-adhesion-of-listeria-monocytogenes-to-polystyrene
#5
J J Ahire, D D Robertson, A J van Reenen, L M T Dicks
Surfactin-loaded polyvinyl alcohol (PVA) nanofibers were spun using gravity electrospinning. Scanning electron microscopy (SEM) images showed that nanofibers spun with surfactin are free from bead formation and uniform in diameter. The average nanofiber diameters were decreased (273±39nm, 259±39nm and 217±33nm) with increasing levels of surfactin (0.5, 1.0 and 1.5%, w/v) into PVA (10%, w/v). The 10% (w/v) PVA had average fiber diameter of 303±33nm. Atomic force microscopy (AFM) analysis showed that fibers spun with surfactin are not smooth as PVA fibers...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532025/new-tetrahedral-zinc-halide-schiff-base-complexes-synthesis-crystal-structure-theoretical-3d-hirshfeld-surface-analyses-antimicrobial-and-thermal-studies
#6
L Taghizadeh, M Montazerozohori, A Masoudiasl, S Joohari, J M White
A new bidentate Schiff base ligand named as N,N'-bis((E)-3-phenylallylidene)butane-1,4-diamine (L) and three its zinc halide complexes were synthesized and characterized by FT-IR, (1)H NMR, (13)C NMR and UV-Vis spectroscopy. The crystal structure of zinc bromide and iodide complexes were characterized using single crystal X-ray diffraction. The two structures are isomorphous, crystallizing in the monoclinic crystal system with space group C2/c with closely similar unit cell dimensions. In these complexes, the Zn(II) ion is in the center of a distorted tetrahedral environment completed by two iminic nitrogen atoms of Schiff base ligand and two halide anions...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532009/exploring-recent-developments-to-improve-antioxidant-anti-inflammatory-and-antimicrobial-efficacy-of-curcumin-a-review-of-new-trends-and-future-perspectives
#7
REVIEW
Zahid Hussain, Hnin Ei Thu, Muhammad Wahab Amjad, Fahad Hussain, Tarek A Ahmed, Shahzeb Khan
Curcumin derivatives have been well-documented due to their natural antioxidant, antimicrobial and anti-inflammatory activities. Curcuminoids have also gained widespread recognition due to their wide range of other activities which include anti-infective, anti-mutagenic, anticancer, anti-coagulant, antiarthrititc, and wound healing potential. Despite of having a wide range of activities, the inherent physicochemical characteristics (poor water solubility, low bioavailability, chemical instability, photodegradation, rapid metabolism and short half-life) of curcumin derivatives limit their pharmaceutical significance...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531982/study-of-the-keratin-based-therapeutic-dermal-patches-for-the-delivery-of-bioactive-molecules-for-wound-treatment
#8
Kush Kumar Nayak, Pratima Gupta
In the present study, dressing materials were fabricated in the form of dermal patches. The keratin based biocompatible materials, namely Keratin/Alginate, Keratin/Agar, and Keratin/Gellan were developed as therapeutic dermal patches. The patches were coated with green synthesized silver nanoparticles to prevent the microbial infection and were found to be antimicrobial against pathogens. Papain was used in the patches to acquire the enzymatic cell debridement and its activity was measured by reduction rate of benzoyl-l-arginine ethyl ester...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531875/elaboration-of-antibacterial-plastic-surfaces-by-a-combination-of-antiadhesive-and-biocidal-coatings-of-natural-products
#9
Jean-Baptiste Paris, Damien Seyer, Thierry Jouenne, Pascal Thébault
Antibacterial polyolefins surfaces, combining biocidal and antiadhesive properties, were elaborated by a covalent grafting of antimicrobial peptides (AMPs), able to kill adherent bacteria, on a pre-immobilized hyaluronic acid (HA) layer, able to repel the micro-organisms. Different HA activation rate for its immobilization, were used to change HA layer morphology and number of residual free carboxylic acid functions for AMPs grafting. Based on adhesion tests on Staphylococcus epidermidis and microscopy fluorescent observations, the presence of the two combined properties was shown to be depended on the HA activation rate...
May 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28531095/synthesis-of-1-2-3-triazolo-4-5-h-quinolone-derivatives-with-novel-anti-microbial-properties-against-metronidazole-resistant-helicobacter-pylori
#10
Mohammad Abu-Sini, Amal Mayyas, Nehaya Al-Karablieh, Rula Darwish, Yusuf Al-Hiari, Talal Aburjai, Shereen Arabiyat, Luay Abu-Qatouseh
Helicobacter pylori infection can lead to gastritis, peptic ulcer, and the development of mucosa associated lymphoid tissue (MALT) lymphoma. Treatment and eradication of H. pylori infection can prevent relapse and accelerate the healing of gastric and duodenal ulcers as well as regression of malignancy. Due to the increasing emergence of antibiotic resistance among clinical isolates of H. pylori, alternative approaches using newly discovered antimicrobial agents in combination with the standard antibiotic regimens for the treatment of H...
May 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28530570/enhanced-antimicrobial-activity-of-essential-oil-components-immobilized-on-silica-particles
#11
María Ruiz-Rico, Édgar Pérez-Esteve, Andrea Bernardos, Félix Sancenón, Ramón Martínez-Máñez, María D Marcos, José M Barat
The antimicrobial activity of essential oils components (EOCs) is well-known. However, their high volatility and powerful aroma limit their application in the formulation of a wide range of food products. In this context, the antimicrobial activity of carvacrol, eugenol, thymol and vanillin grafted onto the surface of three silica supports with different morphologies, textural properties and chemical reactivities (fumed silica, amorphous silica and MCM-41) was evaluated herein. Materials characterization revealed a good immobilization yield and all the devices showed a micro-scale particle size...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530300/physicochemical-and-antimicrobial-properties-of-%C3%AE%C2%B5-polylysine-carboxymethyl-chitosan-polyelectrolyte-complexes-and-their-effect-against-spoilage-microorganisms-in-raw-pork
#12
Liang Guo, Yuecheng Meng, Sheng Fang
This study investigated the properties of polyelectrolyte complexes (PECs) fabricated by using ε-polylysine (EPL) and N,O-carboxymethyl chitosan (NOCC) and their potential applications in raw pork. The phase behaviors of PECs in aqueous solutions are characterized by the ζ-potential, mean radius and turbidimetric measurements. Stable colloidal and soluble PEC systems can be fabricated by carefully adjusting the mass ratio of NOCC to EPL. The minimum inhibitory concentration (MIC) assay showed that the colloidal and soluble PECs could maintain the antimicrobial activity of EPL in a laboratory medium...
May 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28530279/bifunctional-antimicrobial-conjugates-and-hybrid-antimicrobials
#13
REVIEW
P Klahn, M Brönstrup
Covering: up to the end of 2016Novel antimicrobial drugs are continuously needed to counteract bacterial resistance development. An innovative molecular design strategy for novel antibiotic drugs is based on the hybridization of an antibiotic with a second functional entity. Such conjugates can be grouped into two major categories. In the first category (antimicrobial hybrids), both functional elements of the hybrid exert antimicrobial activity. Due to the dual targeting, resistance development can be significantly impaired, the pharmacokinetic properties can be superior compared to combination therapies with the single antibiotics, and the antibacterial potency is often enhanced in a synergistic manner...
May 22, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28530195/facile-synthesis-of-silver-nanoparticles-mediated-by-polyacrylamide-reduction-approach-to-antibacterial-application
#14
Hosam I Salaheldin, Meshal H K Almalki, Abd Elhameed M Hezma, Gamal E H Osman
The current time increase in the prevalence of antibiotic resistant 'super-bugs' and the risks associated with food safety have become global issues. Therefore, further research is warranted to identify new and effective antimicrobial substances. Silver nanoparticles (Ag-NPs) were synthesized by autoclaving technique using, different concentrations of Ag salt (AgNO3) solution (1, 5, 10, and 25 mM). Their presence was confirmed by a surface plasmon resonance band at ∼435 nm using UV-Vis absorption spectra...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28530185/effect-of-gnp-functionalisation-and-multiple-n-methylation-of-%C3%AE-amyloid-residue-32-37-on-gram-positive-bacterium
#15
Nanjundaswamy Marishetty Hemmaragala, Heidi Abrahamse, Blassan P George
In the previous report, the authors showed the gold nanoparticle (GNP) functionalised multiple N-methylated fragments of the residue (32-37) of beta (β)-amyloid protein (1-42), CGGIGLMVG and CGGGGGIGLMVG toward disruption of β-amyloid (1-42), the predominant component of senile plaques. Herein the in vitro antimicrobial activities of both normal and multiple N-methylated sequences of CGGIGLMVG and CGGGGGIGLMVG were screened and it was found that all the eight sequences including four (non-functionalised with GNP) to possess activity against both Gram-positive [Staphylococcus aureus (ATCC 43300) and Enterococcus faecalis (ATCC 5129)] and Gram-negative [Escherichia coli (ATCC 35218), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 700603)] bacteria...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28529865/hyaluronic-acid-and-its-composites-as-a-local-antimicrobial-antiadhesive-barrier
#16
REVIEW
C L Romanò, E De Vecchi, M Bortolin, I Morelli, L Drago
Living in biofilms is probably the most common condition for bacteria and fungi and biofilm-related infections account for the majority of bacterial infectious diseases worldwide. Among others biofilm-related infections, those associated with implanted biomaterials have an enormous and still largely underestimated impact in orthopaedics and trauma, cardio-surgery and several other surgical disciplines. Given the limited efficacy of existing antibiotics in the prevention and treatment of bacterial biofilms, new strategies are needed to protect implants and host tissues, overcoming the striking ability of the microorganisms to adhere on different surfaces and to immediately protect themselves by forming the biofilm matrix...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28529517/role-of-silicon-on-plant-pathogen-interactions
#17
REVIEW
Min Wang, Limin Gao, Suyue Dong, Yuming Sun, Qirong Shen, Shiwei Guo
Although silicon (Si) is not recognized as an essential element for general higher plants, it has beneficial effects on the growth and production of a wide range of plant species. Si is known to effectively mitigate various environmental stresses and enhance plant resistance against both fungal and bacterial pathogens. In this review, the effects of Si on plant-pathogen interactions are analyzed, mainly on physical, biochemical, and molecular aspects. In most cases, the Si-induced biochemical/molecular resistance during plant-pathogen interactions were dominated as joint resistance, involving activating defense-related enzymes activates, stimulating antimicrobial compound production, regulating the complex network of signal pathways, and activating of the expression of defense-related genes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28528648/copper-and-antibiotics-discovery-modes-of-action-and-opportunities-for-medicinal-applications
#18
Alex G Dalecki, Cameron L Crawford, Frank Wolschendorf
Copper is a ubiquitous element in the environment as well as living organisms, with its redox capabilities and complexation potential making it indispensable for many cellular functions. However, these same properties can be highly detrimental to prokaryotes and eukaryotes when not properly controlled, damaging many biomolecules including DNA, lipids, and proteins. To restrict free copper concentrations, all bacteria have developed mechanisms of resistance, sequestering and effluxing labile copper to minimize its deleterious effects...
2017: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/28528545/discovery-and-biosynthesis-of-gladiolin-a-burkholderia-gladioli-antibiotic-with-promising-activity-against-mycobacterium-tuberculosis
#19
Lijiang Song, Matthew Jenner, Joleen Masschelein, Cerith Jones, Matthew J Bull, Simon R Harris, Ruben C Hartkoorn, Anthony Vocat, Isolda Romero-Canelón, Paul Coupland, Gordon Webster, Matthew Dunn, Rebecca Weiser, Christopher Paisey, Stewart T Cole, Julian Parkhill, Eshwar Mahenthiralingam, Gregory L Challis
An antimicrobial activity screen of Burkholderia gladioli BCC0238, a clinical isolate from a cystic fibrosis patient, led to the discovery of gladiolin, a novel macrolide antibiotic with potent activity against Mycobacterium tuberculosis H37Rv. Gladiolin is structurally-related to etnangien, a highly unstable antibiotic from Sorangium cellulosum that is also active against Mycobacteria. Like etnangien, gladiolin was found to inhibit RNA polymerase, a validated drug target in M. tuberculosis. However, gladiolin lacks the highly labile hexaene moiety of etnangien and was thus found to possess significantly increased chemical stability...
May 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28528251/biological-activity-and-safety-profile-of-the-essential-oil-from-fruits-of-heracleum-mantegazzianum-sommier-levier-apiaceae
#20
Krystyna Skalicka-Woźniak, Agnieszka Grzegorczyk, Łukasz Świątek, Magdalena Walasek, Jarosław Widelski, Barbara Rajtar, Małgorzata Polz-Dacewicz, Anna Malm, Hosam O Elansary
A composition of essential oils obtained from Heracleum mantegazzianum (Apiaceae) was examined using a GC-MS method. n-Octyl acetate (19.92%), n-hexyl-2-methylbutanoate (10.84%), n-octanol (10.13%), n-octyl butanoate (8.88%), n-octyl-2-methylbutanoate (8.01%), n-hexyl acetate (7.11%), n-octyl isobutanoate (5.5%) and n-hexyl isobutanoate (5.43%) were the main compounds. The high-performance counter-current chromatography was applied for purification of aliphatic alcohols and esters. A mixture of n-hexane, acetonitrile and tetr-butyl methyl ether (1:1:0...
May 17, 2017: Food and Chemical Toxicology
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