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Antimicrobial Activity

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https://www.readbyqxmd.com/read/29667993/transition-metal-complexes-of-a-versatile-polyalkoxy-oxazolidine-based-ligand-derived-from-in-situ-cyclization
#1
Ayaan Saleem, Paulina A Kobielska, Klaus Harms, Maria G Katsikogianni, Richard Telford, Ghenadie Novitchi, Sanjit Nayak
One-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6). Magnetic studies show dominant antiferromagnetic interaction in tetranuclear iron (FeIII4) complex 5 and presence of the slow relaxation of magnetisation in 6. The compounds were also studied for their antibacterial properties...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667836/molecular-dynamics-simulations-are-redefining-our-view-of-peptides-interacting-with-biological-membranes
#2
Jakob P Ulmschneider, Martin B Ulmschneider
Ever since the first molecular mechanics computer simulations of biological molecules became possible, there has been the dream to study all complex biological phenomena in silico, simply bypassing the enormous experimental challenges and their associated costs. For this, two inherent requirements need to be met: First, the time scales achievable in simulations must reach up to the millisecond range and even longer. Second, the computational model must accurately reproduce what is measured experimentally. Despite some recent successes, the general consensus in the field to date has been that neither of these conditions have yet been met and that the dream will be realized, if at all, only in the distant future...
April 18, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29667550/in-vitro-studies-on-cytotoxic-dna-protecting-antibiofilm-and-antibacterial-effects-of-biogenic-silver-nanoparticles-prepared-with-bergenia-ciliata-rhizome-extract
#3
Ghazna Zia, Haleema Sadia, Shabnam Nazir, Kiren Ejaz, Shaukat Ali, Ihsan-Ul-Haq, Tariq Iqbal, Muhammad Abdul Rauf Khan, Abida Raza, Saiqa Andleeb
BACKGROUND: Many health hazardous diseases are caused by clinical pathogens. Drug-resistant microbes are one of the major health problems in the world. To overcome the effect of infectious diseases new antimicrobial agent from nature has been explored which is environmentally friendly, less costly and more effective for the development of next-generation drugs. Bergenia ciliata and silver nitrate both have medicinal properties. OBJECTIVES: The aim of the current research was to evaluate the cytotoxic, and antibacterial effect of green synthesized nanoparticles using Bergenia ciliata rhizome against clinical bacterial pathogens...
April 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29667274/impact-of-farnesol-and-corsodyl-%C3%A2-on-candida-albicans-forming-dual-biofilm-with-streptococcus-mutans
#4
Lucia Černáková, Luisa Jordao, Helena Bujdáková
OBJECTIVE: This work studied the biofilm formed by Candida albicans and Streptococcus mutans on a hydroxyapatite surface after exposure to the quorum-sensing molecule farnesol (200 μM) in comparison with the diluted mouthwash Corsodyl® (0.0001% chlorhexidine digluconate). MATERIALS AND METHODS: The cytotoxicity of farnesol was evaluated by Galleria melonella surviving assay. The viability of biofilm cells after exposure to farnesol and Corsodyl® was determined by colony-forming units...
April 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29667009/encapsulating-viability-of-multi-strain-lactobacilli-as-potential-probiotic-in-pigs
#5
Sudthidol Piyadeatsoontorn, Rutjawate Taharnklaew, Tewa Upathanpreecha, Pairat Sornplang
Important aspects of the selection of probiotics to be used for mixing in animal feed include host species specificity and probiotic cell survival during production and storage of their products. The research was to screen and investigate some probiotic properties of lactic acid bacteria (LAB) isolated from pig fecal samples. One hundred and thirty-eight representative LAB isolates, which were isolated from 51 pig fecal samples, were tested for acid and bile tolerance, antimicrobial susceptibility, antibacterial activity, potential adhesion to the cell surface, and survival rates when stored in varied microencapsulation forms: freeze-dried, spray-dried, and micro-beads...
April 17, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29666664/oral-fosfomycin-for-the-treatment-of-acute-and-chronic-bacterial-prostatitis-caused-by-multidrug-resistant-escherichia-coli
#6
REVIEW
George G Zhanel, Michael A Zhanel, James A Karlowsky
Acute and chronic bacterial prostatitis in outpatients is commonly treated with oral fluoroquinolones; however, the worldwide dissemination of multidrug-resistant (MDR) Escherichia coli has resulted in therapeutic failures with fluoroquinolones. We reviewed the literature regarding the use of oral fosfomycin in the treatment of acute and chronic prostatitis caused by MDR E. coli . All English-language references on PubMed from 1986 to June 2017, inclusive, were reviewed from the search "fosfomycin prostatitis...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29666548/inhibitory-effect-of-soy-saponins-on-the-activity-of-%C3%AE-lactamases-including-new-delhi-metallo-%C3%AE-lactamase-1
#7
Hitoshi Horie, Asuka Chiba, Shigeo Wada
β-Lactamase-producing bacteria encode enzymes that inactivate β-lactam antibiotics by catalyzing the hydrolysis of the β-lactam ring. Crude soy saponins were observed to have synergistic effects on the antimicrobial activity of β-lactam antibiotics against β-lactamase-producing Staphylococcus aureus strains. Furthermore, the activities of β-lactamases derived from Enterobacter cloacae , Escherichia coli , and S. aureus were decreased significantly in the presence of crude soy saponins. This inhibitory effect was also observed against the New Delhi metallo-β-lactamase 1 (NDM-1), an enzyme whose activity is not inhibited by the current β-lactamase inhibitors...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666540/antimicrobial-antioxidant-and-probiotics-characterization-of-dominant-bacterial-isolates-from-traditional-fermented-fish-of-manipur-north-east-india
#8
Sambanduram Samarjit Singh, Surajit De Mandal, Esther Lalnunmawii, Nachimuthu Senthil Kumar
Utonga - kupsu , Hentak and Ngari are traditional fermented fish products produced by the Manipuri people living in the North-Eastern part of India. The present study was designed with the aim to isolate, identify and characterize the microorganisms present in these fermented foods. Bacterial pure cultures were isolated using serially diluted samples and were further identified by conventional biochemical tests and Sanger sequencing of 16s rRNA gene. Results show that the number of bacterial count in Nutrient agar and Starch casein agar was 14-20 and 10-16 CFU/g, respectively...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666532/effect-of-argel-solenostemma-argel-leaf-extract-on-quality-attributes-of-chicken-meatballs-during-cold-storage
#9
Fahad Y Al-Juhaimi, Syed A Shahzad, Ali S Ahmed, Oladipupo Q Adiamo, Isam A Mohamed Ahmed, Omer N Alsawmahi, Kashif Ghafoor, Elfadil E Babiker
This study aimed to evaluate the antioxidant activity of Argel leaf water extract (ALWE) and its effect at different concentrations (0, 5, 10, and 20 mg/100 mL) on the antioxidant, antimicrobial, physicochemical, and sensory attributes of chicken meatballs during cold storage. ALWE contained substantial quantities of total phenolic content (TPC), anthocyanin, and exhibited high DPPH scavenging activity. ALWE incorporation in chicken meatballs had a varying effect on the chemical composition and sensory attributes of the product...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29665857/the-htlv-1-oncoprotein-tax-is-modified-by-the-ubiquitin-related-modifier-1-urm1
#10
Rita Hleihel, Behzad Khoshnood, Ingrid Dacklin, Hayssam Omran, Carine Mouawad, Zeina Dassouki, Marwan El-Sabban, Margret Shirinian, Caroline Grabbe, Ali Bazarbachi
BACKGROUND: Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity and subcellular localization of Tax is strongly influenced by posttranslational modifications, among which ubiquitylation and SUMOylation have been identified as key regulators of the nuclear/cytoplasmic shuttling of Tax, as well as its ability to activate NF-κB signaling...
April 17, 2018: Retrovirology
https://www.readbyqxmd.com/read/29665678/lectin-functionalized-composite-hydrogels-for-capture-and-killing-of-carbapenem-resistant-pseudomonas-aeruginosa
#11
Nicholas Bodenberger, Dennis Kubiczek, Daniel Halbgebauer, Vittoria Rimola, Sebastian Wiese, Daniel Mayer, Armando Alexei Rodr Iacute Guez Alfonso, Ludger Ständker, Steffen Stenger, Frank Rosenau
Infections with multi-resistant pathogens are a leading cause for mortality worldwide. Just recently, the world health organization (WHO) increased the threat rating for multi-resistant Pseudomonas aeruginosa to the highest possible level. With this background it is crucial to develop novel materials and procedures in the fight against multi-resistant pathogens. In this study we present a novel antimicrobial material, which could find applications as a wound dressing or antimicrobial coating. Lectins are multivalent sugar-binding proteins, which can be found in a variety of plants and bacteria, where they are associated with biofilm formation...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29665495/towards-better-microbial-safety-of-fresh-produce-chlorophyllin-based-photosensitization-for-microbial-control-of-foodborne-pathogens-on-cherry-tomatoes
#12
Egle Paskeviciute, Bernadeta Zudyte, Zivile Luksiene
The aim of this study is to evaluate the antimicrobial efficiency of Chlorophyllin-based photosensitization for microbial control of cherry tomatoes. Chlorophyllin-based photosensitization (1.5 × 10-4  M, 3 J/cm2 ) significantly (2.4 log) reduced the population of naturally distributed surface attached various mesophilic bacteria (microbiota) on tomatoes. Moreover, the population of thermoresistant strains of food pathogens Bacillus cereus and Listeria monocytogenes inoculated on tomatoes was reduced by 1...
April 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29665443/activity-of-a-nitric-oxide-generating-wound-treatment-system-against-wound-pathogen-biofilms
#13
Richard D Waite, Joanne E Stewart, Abish S Stephen, Robert P Allaker
Wound bioburden plays an important role in impaired healing and the development of infection-related complications. The objective of this study was to determine the efficacy of an innovative two-layer nitric oxide generating system (NOx) to prevent and treat biofilms formed by bacterial and fungal pathogens commonly associated with wound infection, and activity against Pseudomonas aeruginosa virulence factors. Single and mixed species biofilms were grown for 24h on nitrocellulose filters placed on agar. Filters were covered with either NOx or placebo, before and after biofilm formation...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29665436/antimicrobial-resistance-and-molecular-characterization-of-pantoea-agglomerans-isolated-from-rainbow-trout-oncorhynchus-mykiss-fry
#14
Izzet Burcin Saticioglu, Muhammed Duman, Soner Altun
Aquaculture has become an important candidate as an animal protein source through its growth over the last decade. Based upon a report from the Food and Agriculture Organization of the United Nations, it is the fastest growing sector of the food industry, yet the pathogenicity of many biological agents involved in aquaculture is still unknown. In this study, we isolated Pantoe agglomerans from diseased rainbow trout on several occasions and also attempted to determine their phenotypic and genotypic characteristics, including antimicrobial resistance, of four bacterial isolates...
April 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29665368/streptomyces-thermoviolaceus-src3-strain-as-a-novel-source-of-the-antibiotic-adjuvant-streptazolin-a-statistical-approach-toward-the-optimized-production
#15
Ibtissem Djinni, Warda Djoudi, Samiha Souagui, Farida Rabia, Sihem Rahmouni, Ines Mancini, Mouloud Kecha
Streptomyces thermoviolaceus SRC3, a newly isolated actinobacterial strain from Algerian river sediments, exhibited a broad activity against various bacterial and yeast human pathogens (Salmonella typhi ATCC 14028, Vibrio cholerae ATCC 14035, MRSA ATCC 43300 and Candida albicans ATCC 10231). The strain SRC3 was selected from thirty nine actinobacterial isolates and identified as S. thermoviolaceus based on morphology, cultural properties, physiological analyses and 16S rRNA gene sequencing. Culture parameters for the antibiotic production were optimized by sequential statistical strategy including Plackett-Burman design (PBD) and Response Surface Methodology (RSM)...
April 14, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29665030/dermatologic-toxicity-from-novel-therapy-using-antimicrobial-peptide-ll-37-in-melanoma-a-detailed-examination-of-the-clinicopathologic-features
#16
Tsetan Dolkar, Celestine M Trinidad, Kelly C Nelson, Rodabe N Amaria, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Jonathan L Curry, Phyu P Aung
LL-37 is a naturally occurring 37-amino acid that is part of innate immunity in human skin. Preclinical studies have demonstrated that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a Phase 1 clinical trial for melanoma patients with cutaneous metastases. We report dermatologic toxicity in a 63-year-old woman with stage IIIC melanoma of the right calf and inguinal lymph nodes...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29665026/anhydrous-polymer-based-coating-with-sustainable-controlled-release-functionality-for-facile-efficacious-impregnation-and-delivery-of-antimicrobial-peptides
#17
Kaiyang Lim, Rathi Saravanan, Kian Long Kelvin Chong, Hwee Mian Sharon Goh, Ray Rong Yuan Chua, Paul Anantharajah Tambyah, Matthew Wook Chang, Kimberly A Kline, Susanna Su Jan Leong
Anhydrous polymers are actively explored as alternative materials to overcome limitations of conventional hydrogel-based antibacterial coating. However, the requirement for strong organic solvent in polymerization reactions often necessitates extra protection steps for encapsulation of target biomolecules, lowering encapsulation efficiency and increasing process complexity. This study reports a novel coating strategy that allows direct solvation and encapsulation of antimicrobial peptides (HHC36) into anhydrous polycaprolactone (PCL) polymer-based dual layer coating...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29663934/fructose-enhanced-antimicrobial-activity-of-silver-nanoparticle-embedded-polymersome-nanocarriers
#18
Ilia Gelfat, Benjamin M Geilich, Thomas J Webster
In recent years, an increasing body of research has indicated that the antimicrobial activity of certain antibiotic drugs can be enhanced by the addition of specific metabolites. This study aimed to incorporate these findings into polymersomes (novel polymer-based nanoscale drug delivery vehicles) which can be loaded with various therapeutic molecules and nanoparticles. Polymersome technology has shown promising results in treating antibiotic-resistant infections by co-encapsulating the antibiotic methicillin with silver nanoparticles...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663932/studies-on-the-antibacterial-activity-and-mechanism-of-antimicrobial-peptides-against-drug-resistant-bacteria
#19
Xiaofang Luo, Yanjun Liu, Zuodong Qin, Zhiyuan Jin, Liting Xu, Yang Liu, Linyan Cao, Fulin He, Xiaohong Gu, Xiaoping Ouyang
Antibiotic resistance is a growing threat to human health. More than anything else, multidrug-resistant gram-negative bacteria pose the biggest challenge to healthcare, which is predominantly due to the lack of effective therapeutic options. In the present study, we investigated the activities of peptides HX-12A, HX-12B and HX-12C against MDRAB and MDRKP isolates in vitro. Those three peptides displayed high antibacterial activities and rapid bactericidal effects against MDRAB and MDRKP isolates. Additionally, the peptides retained their activity even being present in pH 6...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663928/a-tiered-experimental-approach-for-characterization-and-silver-release-of-silver-containing-wound-dressings
#20
Liming Xu, Ru Bai, Xiang Cheng, Anliang Shao, Liang Chen, Shuxin Qu, Chunying Chen
Silver-containing dressings are widely used for wound care owing to their broad-spectrum microbicidal activity. However, the potential adverse effects on human health emerging from exposure to their active ingredients (silver ions or nanoparticles) have resulted in widespread concerns about their use. The release profiles of various chemical forms of silver (Ag) from silver-containing dressing are closely related to their bioavailability and potential adverse effects on the body. In this research, we demonstrated a tiered experimental approach for systematic characterization and assessment of silver-containing wound dressing, which provides information for risk assessments...
March 1, 2018: Journal of Biomedical Nanotechnology
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