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https://www.readbyqxmd.com/read/29678603/chebulagic-acid-chebulinic-acid-and-gallic-acid-the-active-principles-of-triphala-inhibit-tnf%C3%AE-induced-pro-angiogenic-and-pro-inflammatory-activities-in-retinal-capillary-endothelial-cells-by-inhibiting-p38-erk-and-nfkb-phosphorylation
#1
Sivasankar Shanmuganathan, Narayanasamy Angayarkanni
Tumor necrosis factor-α (TNFα) a pleiotropic cytokine induces pro-inflammatory and pro-angiogenic changes in conditions such as diabetic retinopathy (DR) and neovascular age related macular degeneration (NV-AMD). Hence, inhibition of TNFα mediated changes can benefit the management of DR and NV-AMD. Triphala, an ayurvedic herbal preparation is known to have immunomodulatry functions. In this study we evaluated the alcoholic extract of triphala (AlE) and its compounds Chebulagic acid (CA), Chebulinic acid (CI) and Gallic acid (GA) for their anti-TNFα activity...
April 17, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29678043/an-automated-technique-to-construct-a-knowledge-base-of-traditional-chinese-herbal-medicine-for-cancers-an-exploratory-study-for-breast-cancer
#2
Phung Anh Nguyen, Hsuan-Chia Yang, Rong Xu, Yu-Chuan Jack Li
Traditional Chinese Medicine utilization has rapidly increased worldwide. However, there is limited database provides the information of TCM herbs and diseases. The study aims to identify and evaluate the meaningful associations between TCM herbs and breast cancer by using the association rule mining (ARM) techniques. We employed the ARM techniques for 19.9 million TCM prescriptions by using Taiwan National Health Insurance claim database from 1999 to 2013. 364 TCM herbs-breast cancer associations were derived from those prescriptions and were then filtered by their support of 20...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677121/prophylactic-neuroprotection-of-total-glucosides-of-paeoniae-radix-alba-against-semen-strychni-induced-neurotoxicity-in-rats-suppressing-oxidative-stress-and-reducing-the-absorption-of-toxic-components
#3
Shujuan Li, Yanjie Chu, Ruowen Zhang, Linjia Sun, Xiaohui Chen
Strychnos alkaloids (SAs) are the main toxic constituents in Semen Strychni, a traditional Chinese medicine, which is known for its fatal neurotoxicity. Hence, the present study was carried out to evaluate the neurotoxicity induced by SAs and the pre-protective effects of the total glucosides of Paeoniae Radix Alba (TGP). An SA brain damage model was firstly established. The neurotoxicity induced by SAs and the pre-protective effects of TGP were confirmed by physical and behavioral testing, biochemical assay, and histological examination...
April 20, 2018: Nutrients
https://www.readbyqxmd.com/read/29677095/milling-the-mistletoe-nanotechnological-conversion-of-african-mistletoe-loranthus-micranthus-intoantimicrobial-materials
#4
Muhammad Sarfraz, Sharoon Griffin, Tamara Gabour Sad, Rama Alhasan, Muhammad Jawad Nasim, Muhammad Irfan Masood, Karl Herbert Schäfer, Chukwunonso E C C Ejike, Cornelia M Keck, Claus Jacob, Azubuike P Ebokaiwe
Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm...
April 20, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29676114/-pharmacological-effect-of-combined-administration-of-natures-tastes-and-components-of-chinese-herbal-compounds
#5
REVIEW
Chun-Yan Lv, Shao-Wa Lv, Guo-Yu Li, Hai-Xue Kuang
The combined administration of traditional Chinese medicine (TCM) aims at comprehensive adjustment of body based on the theory of TCM and the theory of Chinese medicine property. The natures and tastes of TCM are the core of the theory of TCM property. The combined administration of natures and tastes of TCM is one of the important theories of prescription compatibility. The objective of study on the combined administration of natures and tastes of prescriptions according to symptoms of disease is to clarify the compatibility mechanism of prescriptions...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676106/-medication-regularity-and-potential-targets-of-professor-xu-jing-fan-s-prescription-for-treating-ulcerative-colitis
#6
Li-Qin Ning, Bai Ye, Hong Shen, Wei-Min Lu, Dan-Hua Xu, Jing Yan, Chang Tan, De-Cai Tang
Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and quality of life of patients, and is listed as one of modern refractory diseases by WHO. Professor XU Jing-fan, a great master of traditional Chinese medicine, has accumulated rich experiences in the treatment of UC. The study collected Professor XU's 77 prescriptions of treating UC, analyzed the frequency of traditional Chinese medicines and there categories, and investigated the medication regularity by the system clustering method...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676092/-allele-specific-pcr-to-identification-of-achyranthis-bidentatae-radix-and-cyathulae-radix-formula-granules
#7
Hu-Biao Meng, Yuan Yuan, Fu-Yan Liu, Chao Jiang, Yan Jin, Yu-Yang Zhao
To establish a robust and accuracy molecular method to identify Achyranthis Bidentatae Radix and Cyathulae Radix formula granules. ITS sequences of Achyranthes bidentata and Cyathula officinalis were aligned, specific SNPs (single nucleotide polymorphisms) were excavated, specific primers were designed and allele-specific PCR method was established. The genomic DNA was successfully extracted from the herbal medicine and its formula granules by using an improved CTAB (cetyltrimethyl ammonium bromide) method and then performed PCR with the designed primers...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676084/-preparation-and-quality-standard-of-standard-decoction-of-chinese-herbal-medicine-containing-volatile-components-case-study-of-moutan-cortex
#8
Meng-Jiao Jiao, Zhe Deng, Jun Zhang, Shu-Hui Wang, Wen-Jin Cui, Guo-Yuan Zhang, An Liu
To prepare the standard decoction of Moutan Cortex, and research its quality standard. According to the preparation principle of standard decoction of Chinese herbal medicines, the extraction conditions were optimized, and the 14 batches of standard decoction of Moutan Cortex were prepared. The content of paeonol was determined by HPLC; the transfer rate was calculated; and the extraction rate, pH value and the fingerprint of the decoction were determined. The results showed that the transfer rate of paeonol in the standard decoction of 14 batches of samples was at the range of 43...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676083/-research-on-quality-standard-of-processed-cinnamomi-cortex-decoction-pieces-containing-volatile-oil
#9
Zhe Deng, Meng-Jiao Jiao, Jun Zhang, Li Shen, Shu-Hui Wang, Guo-Yuan Zhang, Qing Zhang, An Liu, Yue-Sheng Wang
To build the quality standard of processed Cinnamomi Cortex standard decoction and provide quality reference for Cinnamomi Cortex formula granules. Fourteen batches of Cinnamomi Cortex standard decoction pieces were prepared according to the preparation requirements for standard decoction of Chinese herbal medicine containing volatile oil. With cinnamaldehyde as the quantitative index, the transfer rate and extraction rate were calculated; pH value was determined and HPLC fingerprint analysis method was established...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676082/-research-on-standard-decoction-of-processed-curcumae-longae-rhizoma-containing-volatile-oil
#10
Zhe Deng, Fan Zhang, Meng-Jiao Jiao, Jun Zhang, Jia Shi, Jin-Tang Cheng, An Liu
To prepare processed Curcumae Longae Rhizoma standard decoction, establish its quality standard, provides quality reference for formulated Jianghuang granules and lay a foundation for standard decoction research for the pieces containing volatile oil. Thirteen batches of processed Curcumae Longae Rhizoma standard decoctions were prepared according to the preparation requirements for standard decoction of Chinese herbal medicine containing volatile oil. With curcumin as the detection index, the transfer rate and extraction ratio were calculated; the pH value was determined and HPLC fingerprint analysis method was established...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675725/effect-of-pycnogenol%C3%A2-on-an-experimental-rat-model-of-allergic-conjunctivitis
#11
Ayse Ipek Akyuz Unsal, Tolga Kocaturk, Ceren Gunel, Ibrahim Meteoglu, Imran Kurt Omurlu, Harun Cakmak, Buket Demirci
BACKGROUND: Allergic conjunctivitis (AC) is a frequent and challenging disease in ophthalmology practice. Cell protective effect of Pycnogenol® (PYC) depends on its antioxidant and anti-inflammatory properties. The aim of the study is to investigate the effect of PYC on an experimental AC model. METHODS: Ovalbumin and Al(OH)3 were given seven times intraperitoneally (i.p.) every other day and ovalbumin installed everyday directly on conjunctiva to create an AC rat model...
April 20, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29675572/baicalin-modulates-appl2-glucocorticoid-receptor-signaling-cascade-promotes-neurogenesis-and-attenuates-emotional-and-olfactory-dysfunctions-in-chronic-corticosterone-induced-depression
#12
Chong Gao, Qiaohui Du, Wenting Li, Ruixia Deng, Qi Wang, Aimin Xu, Jiangang Shen
Olfactory dysfunction is often accompanied with anxiety- and depressive-like behaviors in depressive patients. Impaired neurogenesis in hippocampus and subventricular zone (SVZ)-olfactory bulb (OB) contribute to anxiety- and depressive-like behaviors and olfactory dysfunctions. However, the underlying mechanisms of olfactory dysfunction remain unclear. Our previous study indicates that adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), could affect the activity and sensitivity of glucocorticoid receptor (GR) and mediate impaired hippocampal neurogenesis, which contribute the development of depression...
April 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29675284/voltammetric-determination-of-anethole-on-la-2-o-3-cpe-and-bdde
#13
Mateusz Kowalcze, Jan Wyrwa, Małgorzata Dziubaniuk, Małgorzata Jakubowska
In this work, DPV determination of anethole was presented using various carbon, two-diameter (1.5 and 3 mm) electrodes, that is, BDD, GC, CP, and CP doped by La2 O3 and CeO2 nanoparticles. La2 O3 /CPE to our best knowledge was proposed first time. Cyclic voltammograms confirmed totally irreversible electrode electrooxidation process, controlled by diffusion, in which two electrons take part. The most satisfactory sensitivity 0.885 ± 0.016  µ A/mg L-1 in 0.1 mol L-1 acetate buffer was obtained for La2 O3 /CPE with the correlation coefficient r of 0...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29675053/the-potential-effect-of-chinese-herbal-formula-hongqijiangzhi-fang-in-improving-nafld-focusing-on-nlrp3-inflammasome-and-gut-microbiota
#14
Shu Liang, Yupei Zhang, Yuanjun Deng, Yifang He, Yinji Liang, Zien Liang, Yanning Chen, Kairui Tang, Runsen Chen, Qinhe Yang
The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF) on nonalcoholic fatty liver disease (NAFLD) in rats. Male Sprague Dawley (SD) rats were randomly divided into 4 groups ( n = 8): control group was fed a normal diet, three other groups were fed high-fat diets (HFD), and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time. After 16 w, related indices were detected...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29674964/botanical-provenance-of-traditional-medicines-from-carpathian-mountains-at-the-ukrainian-polish-border
#15
REVIEW
Weronika Kozlowska, Charles Wagner, Erin M Moore, Adam Matkowski, Slavko Komarnytsky
Plants were an essential part of foraging for food and health, and for centuries remained the only medicines available to people from the remote mountain regions. Their correct botanical provenance is an essential basis for understanding the ethnic cultures, as well as for chemical identification of the novel bioactive molecules with therapeutic effects. This work describes the use of herbal medicines in the Beskid mountain ranges located south of Krakow and Lviv, two influential medieval centers of apothecary tradition in the region...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29674947/health-and-social-problems-associated-with-recent-novel-psychoactive-substance-nps-use-amongst-marginalised-nightlife-and-online-users-in-six-european-countries
#16
Marie Claire Van Hout, Annemieke Benschop, Michal Bujalski, Katarzyna Dąbrowska, Zsolt Demetrovics, Katalin Felvinczi, Evelyn Hearne, Susana Henriques, Zsuzsa Kaló, Gerrit Kamphausen, Dirk Korf, Joana Paula Silva, Łukasz Wieczorek, Bernd Werse
Continued diversification and use of new psychoactive substances (NPS) across Europe remains a public health challenge. The study describes health and social consequences of recent NPS use as reported in a survey of marginalised, nightlife and online NPS users in the Netherlands, Hungary, Portugal, Ireland, Germany and Poland ( n  = 3023). Some respondents were unable to categorise NPS they had used. Use of ' herbal blends ' and ' synthetic cannabinoids obtained pure ' was most reported in Germany, Poland and Hungary, and use of ' branded stimulants ' and ' stimulants/empathogens/nootropics obtained pure ' was most reported in the Netherlands...
2018: International Journal of Mental Health and Addiction
https://www.readbyqxmd.com/read/29674944/dunye-guanxinning-improves-acute-myocardial-ischemia-reperfusion-injury-by-inhibiting-neutrophil-infiltration-and-caspase-1-activity
#17
Q G Zhang, S R Wang, X M Chen, H N Guo, S Ling, J W Xu
Acute myocardial infarction is the most serious manifestation of cardiovascular disease, and it is a life-threatening condition. Dunye Guanxinning (DG) is a protective traditional Chinese patent herbal medicine with high clinical efficacy and suitable for the treatment of myocardial infarction. However, the mechanism through which it is beneficial is unclear. In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29674230/association-of-herbal-botanic-supplement-use-with-quality-of-life-recurrence-and-survival-in-newly-diagnosed-stage-ii-colon-cancer-patients-a-2-y-follow-up-study
#18
Qiran Chen, Pengcheng Xun, Cari Lewis Tsinovoi, Beate Henschel, Alyce D Fly, Ka He
OBJECTIVES: Our objective was to investigate the association between herbal/botanic supplement use and perceived quality of life (QoL), cancer recurrence, and all-cause mortality in colon cancer patients. METHODS: Patients (n = 453) newly diagnosed with stage II adenocarcinoma of the colon between 2009 and 2011 were recruited from the North Carolina Central Cancer Registry. Data including demographic variables, herbal medicine use and frequency, lifestyle, diet, cancer treatment, and QoL were collected by interviews at diagnosis (baseline) and 1 and 2 y after diagnosis...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29673343/anti-osteoarthritic-effects-of-chondrot-in-a-rat-model-of-collagenase-induced-osteoarthritis
#19
Jiwon Jeong, Kiljoon Bae, Sun-Gil Kim, Dongwook Kwak, Young-Joo Moon, Chan-Hun Choi, Young-Ran Kim, Chang-Su Na, Seon-Jong Kim
BACKGROUND: Previously, we reported that ChondorT showed significant anti-arthritis and anti-inflammatory effects. ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angelicae Gigantis Radix, Clematidis Radix, and Phellodendri Cortex (6:4:4:4:3). The objective of this study was to investigate the effects of ChondroT in collagenase-induced osteoarthritis rat model. METHODS: Osteoarthritis was induced by the injection of collagenase into the right knee joint cavity of rats...
April 19, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29673137/herb-induced-liver-injuries-in-developing-nations-an-update
#20
REVIEW
Cecilia Nwadiuto Amadi, Orish Ebere Orisakwe
The last few decades have seen a rise in the use of herbal supplements, natural products, and traditional medicines. However, there are growing concerns related to the safety and toxicities of these medicines. These herbal medicines are associated with complications such as liver damage with a high incidence of mortalities and morbidities. Clinical manifestations range from asymptomatic cases with abnormal liver functions tests to sudden and severe liver failure necessitating liver transplantation. This work aimed to review the etiology, risk factors, diagnosis, clinical manifestations and selected clinical case reports of herbal hepatotoxicity in developing nations...
April 17, 2018: Toxics
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