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https://www.readbyqxmd.com/read/29445930/zbtb17-loss-of-function-mutation-contributes-to-familial-dilated-cardiomyopathy
#1
Yu-Min Sun, Jun Wang, Ying-Jia Xu, Xin-Hua Wang, Fang Yuan, Hua Liu, Ruo-Gu Li, Min Zhang, Yan-Jie Li, Hong-Yu Shi, Liang Zhao, Xing-Biao Qiu, Xin-Kai Qu, Yi-Qing Yang
Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patients remains unclear. The present study was sought to investigate the association of a genetic variant in the ZBTB17 gene with DCM. A cohort of 158 unrelated patients with idiopathic DCM and a total of 230 unrelated, ethnically matched healthy individuals used as controls were recruited...
February 14, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29415647/contagion-via-magical-thinking-and-via-mere-proximity
#2
Lennea R Bower, Zehra F Peynircioǧlu, Brian E Rabinovitz
People show an irrational dislike for objects that were once contaminated or had come into contact with an undesirable person, even if they are currently indistinguishable from other similar objects. To date, such negative contagion within the magical thinking literature has been shown only with inanimate objects. We addressed a boundary condition to see if it also extended to animate targets (dogs and children) while teasing out mere-proximity effects that would predict a similar contagion in the case of children...
January 2018: Experimental Psychology
https://www.readbyqxmd.com/read/29409092/-gallop-in-the-routineergometrie-only-chore-or-diagnostic-challenge
#3
Stephan Knöchner, K Kronberg, U Schumann
ANAMNESIS:  A 47-year-old recreational sportsman showed in a routine ergometry polymorphic ventricular extrasystoles with good physical performance. INVESTIGATIONS:  In resting ECG impressed ventricular extrasystoles (VES) predominantly right-hand-block-like with superior axis, a long-term ECG yielded up to 100 VES per hour. Echocardiographically imposing 4 - 5 trabeculae, feathered, reticular structures apically in the left and lower in the right ventricle...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29408791/convolutional-invasion-and-expansion-networks-for-tumor-growth-prediction
#4
Ling Zhang, Le Lu, Ronald M Summers, Electron Kebebew, Jianhua Yao
Tumor growth is associated with cell invasion and mass-effect, which are traditionally formulated by mathematical models, namely reaction-diffusion equations and biomechanics. Such models can be personalized based on clinical measurements to build the predictive models for tumor growth. In this paper, we investigate the possibility of using deep convolutional neural networks to directly represent and learn the cell invasion and mass-effect, and to predict the subsequent involvement regions of a tumor. The invasion network learns the cell invasion from information related to metabolic rate, cell density, and tumor boundary derived from multimodal imaging data...
February 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29373752/identity-disturbance-feelings-of-emptiness-and-the-boundaries-of-the-schizophrenia-spectrum
#5
Maja Zandersen, Josef Parnas
Historical and current research on borderline personality disorder reveal certain affinities with schizophrenia spectrum psychopathology. This is also the case for the borderline criteria of "identity disturbance" and "feelings of emptiness," which reflect symptomatology frequently found in schizophrenia and schizotypal personality disorder. Unfortunately, the diagnostic manuals offer limited insight into the nature of these criteria, including possible deviations and similarities with schizophrenia spectrum symptomatology...
January 24, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29370094/undertaking-a-collaborative-rapid-realist-review-to-investigate-what-works-in-the-successful-implementation-of-a-frail-older-person-s-pathway
#6
REVIEW
Éidín Ní Shé, Fiona Keogan, Eilish McAuliffe, Diarmuid O'Shea, Mary McCarthy, Rosa McNamara, Marie Therese Cooney
We addressed the research question "what factors enable the successful development and implementation of a frail older person's pathway within the acute setting". A rapid realist review (RRR) was conducted by adopting the RAMESES standards. We began with a sample of 232 articles via database searches supplemented with 94 additional records including inputs from a twitter chat and a hospital site visit. Our final sample consisted of 18 documents. Following review and consensus by an expert panel we identified a conceptual model of context-mechanism-(resources)-outcomes...
January 25, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29369086/drawing-boundaries-the-difficulty-in-defining-clinical-reasoning
#7
Meredith Young, Aliki Thomas, Stuart Lubarsky, Tiffany Ballard, David Gordon, Larry D Gruppen, Eric Holmboe, Temple Ratcliffe, Joe Rencic, Lambert Schuwirth, Steven J Durning
Clinical reasoning is an essential component of a health professional's practice. Yet clinical reasoning research has produced a notably fragmented body of literature. In this article, the authors describe the pause-and-reflect exercise they undertook during the execution of a synthesis of the literature on clinical reasoning in the health professions. Confronted with the challenge of establishing a shared understanding of the nature and relevant components of clinical reasoning, members of the review team paused to independently generate their own personal definitions and conceptualizations of the construct...
January 23, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29368820/simulation-using-live-adult-service-users-and-moulage-in-a-variety-of-settings
#8
Sharon Edwards, Samantha McCormack
This article shows how simulation can be modified and adapted to benefit higher education institutions (HEIs) in a variety of situations. These situations can involve the engagement of service users (SUs) and moulage, or application of make-up to simulate clinical presentations, to ensure skill enhancement, ultimately to support and empower students so they can achieve their potential. This article describes a unique collaboration between staff at an HEI and SUs, who have worked together in simulation activities...
January 25, 2018: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/29357960/spiritual-care-training-in-healthcare-does-it-really-have-an-impact
#9
Helena Daudt, Margo d'Archangelo, Dominique Duquette
OBJECTIVE: Spiritual care has formed an integral part of palliative care since its inception. People with advanced illnesses, however, frequently report that their spiritual needs are not attended to by their medical care team. The present study examines and describes the impact of a spiritual care training program on practice and cultural change in our Canadian hospice. METHOD: A qualitative case study approach was adopted to gather feedback from hospice staff and volunteers using purposive sampling...
January 23, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29355991/a-functionally-personalized-boundary-condition-model-to-improve-estimates-of-fractional-flow-reserve-with-ct-ct-ffr
#10
Moti Freiman, Hannes Nickisch, Holger Schmitt, Pál Maurovich-Horvat, Patrick M Donnelly, Mani Vembar, Liran Goshen
PURPOSE: The purpose of this study is to develop and evaluate a functionally personalized boundary condition (BC) model for estimating the fractional flow reserve (FFR) from coronary computed tomography angiography (CCTA) using flow simulation (CT-FFR). MATERIALS AND METHODS: CCTA data of 90 subjects with subsequent invasive FFR in 123 lesions within 21 days (range: 0-83) were retrospectively collected. We developed a functionally-personalized BC model accounting specifically for the coronary micro-vascular resistance dependency on the coronary outlets pressure suggested by several physiological studies...
January 22, 2018: Medical Physics
https://www.readbyqxmd.com/read/29331354/specificity-in-etiology-of-subtypes-of-bipolar-disorder-evidence-from-a-swedish-population-based-family-study
#11
Jie Song, Ralf Kuja-Halkola, Arvid Sjölander, Sarah E Bergen, Henrik Larsson, Mikael Landén, Paul Lichtenstein
BACKGROUND: Uncertainty remains whether bipolar I disorder (BDI) and bipolar II disorder (BDII) differ etiologically. We used a population-based family sample to examine the etiological boundaries between BDI and BDII by assessing their familial aggregation/coaggregation and by assessing the coaggregation between them and schizophrenia, depression, attention-deficit/hyperactivity disorder, eating disorders, autism spectrum disorder, substance use disorders, anxiety disorders, and personality disorders...
November 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29320616/epoxy-nanocomposites-filled-with-carbon-nanoparticles
#12
REVIEW
M Martin-Gallego, V Yuste-Sanchez, R Sanchez-Hidalgo, R Verdejo, M A Lopez-Manchado
Over the past decades, the development of high performance lightweight polymer nanocomposites and, in particular, of epoxy nanocomposites has become one the greatest challenges in material science. The ultimate goal of epoxy nanocomposites is to extrapolate the exceptional intrinsic properties of the nanoparticles to the bulk matrix. However, in spite of the efforts, this objective is still to be attained at commercially attractive scales. Key aspects to achieve this are ultimately the full understanding of network structure, the dispersion degree of the nanoparticles, the interfacial adhesion at the phase boundaries and the control of the localization and orientation of the nanoparticles in the epoxy system...
January 10, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29316861/cultures-of-caring-healthcare-scandals-inquiries-and-the-remaking-of-accountabilities
#13
Dawn Goodwin
In the UK, a series of high-profile healthcare 'scandals' and subsequent inquiries repeatedly point to the pivotal role culture plays in producing and sustaining healthcare failures. Inquiries are a sociotechnology of accountability that signal a shift in how personal accountabilities of healthcare professionals are being configured. In focusing on problematic organizational cultures, these inquiries acknowledge, make visible, and seek to distribute a collective responsibility for healthcare failures. In this article, I examine how the output of one particular inquiry - The Report of the Morecambe Bay Investigation - seeks to make culture visible and accountable...
January 1, 2018: Social Studies of Science
https://www.readbyqxmd.com/read/29301519/iterative-co-creation-for-improved-hand-hygiene-and-aseptic-techniques-in-the-operating-room-experiences-from-the-safe-hands-study
#14
Annette Erichsen Andersson, Maria Frödin, Lisen Dellenborg, Lars Wallin, Jesper Hök, Brigid M Gillespie, Ewa Wikström
BACKGROUND: Hand hygiene and aseptic techniques are essential preventives in combating hospital-acquired infections. However, implementation of these strategies in the operating room remains suboptimal. There is a paucity of intervention studies providing detailed information on effective methods for change. This study aimed to evaluate the process of implementing a theory-driven knowledge translation program for improved use of hand hygiene and aseptic techniques in the operating room...
January 4, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29285343/non-invasive-assessment-of-patient-specific-aortic-haemodynamics-from-four-dimensional-flow-mri-data
#15
Lucian Itu, Dominik Neumann, Viorel Mihalef, Felix Meister, Martin Kramer, Mehmet Gulsun, Marcus Kelm, Titus Kühne, Puneet Sharma
We introduce a parameter estimation framework for automatically and robustly personalizing aortic haemodynamic computations from four-dimensional magnetic resonance imaging data. The framework is based on a reduced-order multiscale fluid-structure interaction blood flow model, and on two calibration procedures. First, Windkessel parameters of the outlet boundary conditions are personalized by solving a system of nonlinear equations. Second, the regional mechanical wall properties of the aorta are personalized by employing a nonlinear least-squares minimization method...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29276068/what-is-needed-to-make-low-density-lipoprotein-transport-in-human-aorta-computational-models-suitable-to-explore-links-to-atherosclerosis-impact-of-initial-and-inflow-boundary-conditions
#16
Giuseppe De Nisco, Peng Zhang, Karol Calò, Xiao Liu, Raffaele Ponzini, Cristina Bignardi, Giovanna Rizzo, Xiaoyan Deng, Diego Gallo, Umberto Morbiducci
Personalized computational hemodynamics (CH) is a promising tool to clarify/predict the link between low density lipoproteins (LDL) transport in aorta, disturbed shear and atherogenesis. However, CH uses simplifying assumptions that represent sources of uncertainty. In particular, modelling blood-side to wall LDL transfer is challenged by the cumbersomeness of protocols needed to obtain reliable LDL concentration profile estimations. This paucity of data is limiting the establishment of rigorous CH protocols able to balance the trade-offs among the variety of in vivo data to be acquired, and the accuracy required by biological/clinical applications...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29242397/whole-body-voxel-based-personalized-dosimetry-multiple-voxel-s-value-approach-for-heterogeneous-media-with-non-uniform-activity-distributions
#17
Min Sun Lee, Joong Hyun Kim, Jin Chul Paeng, Keon Wook Kang, Jae Min Jeong, Dong Soo Lee, Jae Sung Lee
Personalized dosimetry with high accuracy is becoming more important because of the growing interests in personalized medicine and targeted radionuclide therapy. Voxel-based dosimetry using dose point kernel or voxel S-value (VSV) convolution is available. However, these approaches do not consider medium heterogeneity. Here, we propose a new method for whole-body voxel-based personalized dosimetry for heterogeneous media with non-uniform activity distributions, which is referred to as the multiple VSV approach...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29230428/an-account-from-the-inside-examining-the-emotional-impact-of-qualitative-research-through-the-lens-of-insider-research
#18
Lori E Ross
The benefits and challenges of insider positionality have been much written about in relation to qualitative research. However, the specific emotional implications of insider research have been little explored. In this manuscript, I aim to bring the literature on insider positionality to the study of emotion in qualitative research through a reflection on my experiences as a "total insider" conducting interviews for a longitudinal qualitative study examining mental health during the transition to parenthood among sexual minority women...
November 2017: Qualitative Psychology
https://www.readbyqxmd.com/read/29228788/understanding-the-experiences-of-middle-school-girls-who-have-received-help-for-non-suicidal-self-injury
#19
Kathleen S Tillman, Michael Prazak, Megan L Obert
This study aimed to understand the experiences of middle school girls who have engaged in non-suicidal self-injury (NSSI) and have received professional help for these behaviors. Participants described engaging in NSSI in response to uncomfortable feelings and invasive negative thoughts. They reported that engaging in NSSI decreased their uncomfortable feelings. While each participant had at least one person in her life who knew about her NSSI, participants did not feel supported or validated by these people...
December 1, 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/29222010/a-novel-nr2f2-loss-of-function-mutation-predisposes-to-congenital-heart-defect
#20
Xiao-Hui Qiao, Qian Wang, Juan Wang, Xing-Yuan Liu, Ying-Jia Xu, Ri-Tai Huang, Song Xue, Yan-Jie Li, Min Zhang, Xin-Kai Qu, Ruo-Gu Li, Xing-Biao Qiu, Yi-Qing Yang
Congenital heart defect (CHD) is the most common type of birth defect in humans and a leading cause of infant morbidity and mortality. Previous studies have demonstrated that genetic defects play a pivotal role in the pathogenesis of CHD. However, the genetic basis of CHD remains poorly understood due to substantial genetic heterogeneity. In this study, the coding exons and splicing boundaries of the NR2F2 gene, which encodes a pleiotropic transcription factor required for normal cardiovascular development, were sequenced in 168 unrelated patients with CHD, and a novel mutation (c...
December 6, 2017: European Journal of Medical Genetics
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