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https://www.readbyqxmd.com/read/27506674/differential-expression-of-skeletal-muscle-genes-following-administration-of-clenbuterol-to-exercised-horses
#1
Heather K Knych, Linda M Harrison, Stacy J Steinmetz, Nadira Chouicha, Phil H Kass
BACKGROUND: Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in horses and as such the potential to affect performance. Clenbuterol decreases the percent fat and increases fat-free mass following high dose administration in combination with intense exercise in horses. In the current study, microarray analysis and real-time PCR were used to study the temporal effects of low and high dose chronic clenbuterol administration on differential gene expression of several skeletal muscle myosin heavy chains, genes involved in lipid metabolism and the β2-adrenergic receptor...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27437032/visceral-adiposity-syndrome
#2
REVIEW
Heno F Lopes, Maria Lúcia Corrêa-Giannella, Fernanda M Consolim-Colombo, Brent M Egan
The association of anthropometric (waist circumference) and hemodynamic (blood pressure) changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of discussions in the last 30 years. Nowadays, blood pressure, body mass index/abdominal circumference, glycemia, triglyceridemia, and HDL-cholesterol concentrations are considered in the definition of Metabolic syndrome, referred as Visceral adiposity syndrome (VAS) in the present review. However, more than 250 years ago an association between visceral and mediastinal obesity with hypertension, gout, and obstructive apnea had already been recognized...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27255554/prognostic-significance-of-synergistic-hexokinase-2-and-beta2-adrenergic-receptor-expression-in-human-hepatocelluar-carcinoma-after-curative-resection
#3
Zhi-Feng Zhang, Xiao-Sha Feng, He Chen, Zhi-Jun Duan, Li-Xia Wang, Dong Yang, Pi-Xu Liu, Qiu-Ping Zhang, Yan-Ling Jin, Zhi-Gang Sun, Han Liu
BACKGROUND: Hexokinase-2 (HK2) and Beta2-adrenergic receptor (Beta2AR) are overexpressed in hepatocellular carcinoma (HCC) tissues and associated with poor prognosis. However, the synergistic effect of HK2 and Beta2AR in HCC prognosis is not elucidated. The present study aims to investigate the association between HK2 and Beta2AR expressions in HCC tissues, and to evaluate the synergistic effect of HK2 and Beta2AR in HCC prognosis. METHODS: Immunohistochemistry of HK2 and Beta2AR was performed on 155 paraffin embedded HCC samples retrieved from the archives of pathology department...
2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27245339/formoterol-decreases-muscle-wasting-as-well-as-inflammation-in-the-rat-model-of-rheumatoid-arthritis
#4
Ana Belén Gómez-SanMiguel, Carolina Gomez-Moreira, María Paz Nieto-Bona, Carmen Fernández-Galaz, Maria Ángeles Villanúa, Ana Isabel Martín, Asunción López-Calderón
Adjuvant-induced arthritis is an experimental model of rheumatoid arthritis that is associated with body weight loss and muscle wasting. β2-adrenergic receptor agonists are powerful anabolic agents that trigger skeletal muscle hypertrophy and have been proposed as a promising treatment for muscle wasting in human patients. The aim of this work was to determine whether formoterol, a selective β2-adrenoreceptor agonist, is able to ameliorate muscle wasting in arthritic rats. Arthritis was induced in male Wistar rats by intradermal injection of Freund's adjuvant...
June 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27046942/maximum-time-of-the-effect-of-antileukotriene-zileuton-in-treatment-of-patients-with-bronchial-asthma
#5
Naim Morina, Gëzim Boçari, Ali Iljazi, Kadir Hyseini, Gunay Halac
OBJECTIVE: Maximum time of the effect of antileukotriene substances - Zileuton in the treatment of patients with bronchial asthma and increased bronchial reactivity and of the salbutamol as agonist of the beta2 adrenergic receptor studied in this work. METHODS: Parameters of the lung function are determined with Body plethysmography. Raw and ITGV were registered and specific resistance (SRaw) was calculated. Zileuton (Zyflo, tbl. 600 mg), producer Cornerstone Therapeutics, USA was used in the research...
February 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/26746354/higenamine-protects-ischemia-reperfusion-induced-cardiac-injury-and-myocyte-apoptosis-through-activation-of-%C3%AE-2-ar-pi3k-akt-signaling-pathway
#6
Mei-ping Wu, Yi-shuai Zhang, Qian-mei Zhou, Jian Xiong, Yao-rong Dong, Chen Yan
Cardiomyocyte apoptosis contributes to ischemic cardiac injury and the development of heart failure. Higenamine is a key component of the Chinese herb aconite root that has been prescribed for treating symptoms of heart failure for thousands of years in the oriental Asian countries. It has been shown that higenamine has anti-apoptotic effects in a few cell types including cardiomyocytes. However, the pharmacological target and molecular mechanism of higenamine in the heart are still not fully illustrated. Herein, we report that higenamine protected myocyte apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR)...
February 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26543414/impact-of-the-tamsulosin-in-alpha-adrenergic-receptor-of-airways-at-patients-with-increased-bronchial-reactibility
#7
Lirim Mustafa, Ali Ilazi, Arta Dauti, Pellumb Islami, Bashkim Kastrati, Hilmi Islami
OBJECTIVE: In this work, effect of tamsulosin as antagonist of alpha1A and alpha1B adrenergic receptor and effect of agonists of beta2 adrenergic receptor-salbutamol in patients with increased bronchial reactibility was studied. METHODS: Parameters of the lung function are determined with Body plethysmography six (6) hours after administration of tamsulosin. Raw and ITGV were registered and specific resistance (SRaw) was calculated as well. Tamsulosin was administered in per os manner as a preparation in the shape of the capsules with a brand name of "Prolosin", produced by Niche Generics Limited, Hitchin, Herts...
August 2015: Materia Socio-medica
https://www.readbyqxmd.com/read/26524508/%C3%AE-2-agonist-clenbuterol-hinders-human-monocyte-differentiation-into-dendritic-cells
#8
Luciana Giordani, Noemi Cuzziol, Tamara Del Pinto, Massimo Sanchez, Sonia Maccari, Alessia Massimi, Donatella Pietraforte, Marina Viora
Clenbuterol (CLB) is a beta2-adrenergic agonist commonly used in asthma therapy, but is also a non-steroidal anabolic drug often abused in sport doping practices. Here we evaluated the in vitro impact of CLB on the physiology and function of human monocytes and dendritic cells (DCs), instrumental in the development of immune responses. We demonstrate that CLB inhibits the differentiation of monocytes into DCs and this effect is specific and dependent on β2-adrenergic receptor (AR) activation. We found that CLB treatment reduced the percentage of CD1a(+) immature DCs, while increasing the frequency of monocytes retaining CD14 surface expression...
December 10, 2015: Experimental Cell Research
https://www.readbyqxmd.com/read/26254103/beta2-adrenergic-activity-modulates-vascular-tone-regulation-in-lecithin-cholesterol-acyltransferase-knockout-mice
#9
S Manzini, C Pinna, M Busnelli, P Cinquanta, E Rigamonti, G S Ganzetti, F Dellera, A Sala, L Calabresi, G Franceschini, C Parolini, G Chiesa
Lecithin:cholesterol acyltransferase (LCAT) deficiency is associated with hypoalphalipoproteinemia, generally a predisposing factor for premature coronary heart disease. The evidence of accelerated atherosclerosis in LCAT-deficient subjects is however controversial. In this study, the effect of LCAT deficiency on vascular tone and endothelial function was investigated in LCAT knockout mice, which reproduce the human lipoprotein phenotype. Aortas from wild-type (Lcat(wt)) and LCAT knockout (Lcat(KO)) mice exposed to noradrenaline showed reduced contractility in Lcat(KO) mice (P<0...
November 2015: Vascular Pharmacology
https://www.readbyqxmd.com/read/26146998/a-common-polymorphism-of-the-human-cardiac-sodium-channel-alpha-subunit-scn5a-gene-is-associated-with-sudden-cardiac-death-in-chronic-ischemic-heart-disease
#10
Boglárka Marcsa, Réka Dénes, Krisztina Vörös, Gergely Rácz, Mária Sasvári-Székely, Zsolt Rónai, Klára Törő, Gergely Keszler
Cardiac death remains one of the leading causes of mortality worldwide. Recent research has shed light on pathophysiological mechanisms underlying cardiac death, and several genetic variants in novel candidate genes have been identified as risk factors. However, the vast majority of studies performed so far investigated genetic associations with specific forms of cardiac death only (sudden, arrhythmogenic, ischemic etc.). The aim of the present investigation was to find a genetic marker that can be used as a general, powerful predictor of cardiac death risk...
2015: PloS One
https://www.readbyqxmd.com/read/25997166/stopping-long-acting-beta2-agonists-laba-for-children-with-asthma-well-controlled-on-laba-and-inhaled-corticosteroids
#11
REVIEW
Kayleigh M Kew, Sean Beggs, Shaleen Ahmad
BACKGROUND: Asthma is the most common chronic medical condition among children and is one of the most common causes of hospitalisation and medical visits. Poorly controlled asthma often leads to preventable exacerbations that require additional medications, hospital stays, or treatment in the emergency department.Long-acting beta2-agonists (LABA) are the preferred add-on treatment for children with asthma whose symptoms are not well controlled on inhaled corticosteroids (ICS). The US Food and Drug Administration has issued a 'black box' warning for LABA in asthma, and now recommends that they be used "for the shortest duration of time required to achieve control of asthma symptoms and discontinued, if possible, once asthma control is achieved"...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25912320/an-in-vivo-mouse-model-of-primary-dysmenorrhea
#12
Lu Yang, Zhengyu Cao, Boyang Yu, Chengzhi Chai
Primary dysmenorrhea (PD) is a common gynecological disorder. Hitherto, animal models which recapitulate clinical features of PD have not been fully established. We aimed to examine whether a pain model in mice could mimic the clinic features of PD. After pretreated with estradiol benzoate (1 mg/kg/day) intraperitoneally (i.p.) for 3 consecutive days, non-pregnant female Imprinting Control Region mice (6-8 weeks old) was injected with 0.4 U of oxytocin to induce the stretching or writhing response which was recorded for a time period of 30 min...
2015: Experimental Animals
https://www.readbyqxmd.com/read/25893811/environmental-factors-and-beta2-adrenergic-receptor-polymorphism-influence-on-the-energy-expenditure-and-nutritional-status-of-obese-women
#13
Eliane Lopes Rosado, Josefina Bressan, J Alfredo Martínez
Our aim was to evaluate the influence of the Gln27Glu polymorphism of the β2-adrenergic receptor (ADRβ2) gene, fat intake and physical activity on the energy expenditure (EE) and nutritional status of obese women. Sixty obese women (30-46 years) participated in the study and were assigned to three groups depending on the genotypes: Gln27Gln, Gln27Glu and Glu27Glu. At baseline and after nutritional intervention, the anthropometric and body composition (bioelectrical impedance), dietary, EE (indirect calorimetry) and biochemical variables were measured...
May 2015: Lipids
https://www.readbyqxmd.com/read/25812281/carvedilol-and-spirulina-may-provide-important-health-protection-to-smokers-and-other-nicotine-addicts-a-call-for-pertinent-research
#14
Mark F McCarty, James H O'Keefe, James J DiNicolantonio
Nicotine and soluble semi-stable aldehydes and ketones in cigarette smoke are key mediators of the elevated risks for vascular disease, cancer, and chronic obstructive pulmonary disease observed in smokers. Nicotine, via sympathetic stimulation, increases risk for both vascular disease and cancer. Comprehensive suppression of sympathetic activity with the well-tolerated drug carvedilol, which inhibits betal 1, beta2 and alphal adrenergic receptors, may be protective to smokers and other nicotine addicts. The soluble aldehydes and ketones in tobacco smoke appear to exert their adverse effects through activation of NADPH oxidase complexes in vascular tissues and in the lungs...
January 2015: Missouri Medicine
https://www.readbyqxmd.com/read/25697013/-effect-of-different-therapy-options-on-bronchial-contraction-in-rats-with-modeled-obstructive-pulmonary-disease
#15
N A Kuzubova, A N Fedin, E S Lebedeva, I S Platonova
In the model of chronic obstructive pulmonary disease, produced in rats by 60-day exposure to nitrogen dioxide, the effect of different options of combination therapy (corticosteroids, anticholinergics, adrenergic agonists) on the functional state of the bronchi was studied. The contractile activity of strips of the bronchi caused by nerve or smooth muscle stimulation was evaluated. Corticosteroid monotherapy resulted in deterioration of the functional state of the bronchial wall neuromuscular apparatus due to corticosteroid resistance, evolving under the influence of long-term exposure to nitrogen dioxide...
September 2014: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
https://www.readbyqxmd.com/read/25682119/genetic-factors-associated-with-exercise-performance-in-atmospheric-hypoxia
#16
REVIEW
Philip J Hennis, Alasdair F O'Doherty, Denny Z H Levett, Michael P W Grocott, Hugh M Montgomery
BACKGROUND AND OBJECTIVE: 'Natural selection' has been shown to have enriched the genomes of high-altitude native populations with genetic variants of advantage in this hostile hypoxic environment. In lowlanders who ascend to altitude, genetic factors may also contribute to the substantial interindividual variation in exercise performance noted at altitude. We performed a systematic literature review to identify genetic variants of possible influence on human hypoxic exercise performance, commenting on the strength of any identified associations...
May 2015: Sports Medicine
https://www.readbyqxmd.com/read/25537861/structural-features-of-%C3%AE-2-adrenergic-receptor-crystal-structures-and-beyond
#17
REVIEW
Injin Bang, Hee-Jung Choi
The beta2-adrenergic receptor (β2AR) family, which is the largest family of cell surface receptors in humans. Extra attention has been focused on the human GPCRs because they have been studied as important protein targets for pharmaceutical drug development. In fact, approximately 40% of marketed drugs directly work on GPCRs. GPCRs respond to various extracellular stimuli, such as sensory signals, neurotransmitters, chemokines, and hormones, to induce structural changes at the cytoplasmic surface, activating downstream signaling pathways, primarily through interactions with heterotrimeric G proteins or through G-protein independent pathways, such as arrestin...
2015: Molecules and Cells
https://www.readbyqxmd.com/read/25445928/differences-in-the-efficacy-and-safety-among-inhaled-corticosteroids-ics-long-acting-beta2-agonists-laba-combinations-in-the-treatment-of-chronic-obstructive-pulmonary-disease-copd-role-of-ics
#18
REVIEW
M Latorre, F Novelli, B Vagaggini, F Braido, A Papi, A Sanduzzi, P Santus, N Scichilone, P Paggiaro
Inhaled corticosteroids (ICS) are frequently recommended for the treatment of asthma and COPD, often in combination with long-acting beta2-agonists (LABA), depending on the severity of the disease and/or on the specific phenotype. Several ICS/LABA combinations are currently available that differ in their pharmacokinetic characteristics and dose of both components. Thus, this review assesses differences in the efficacy and the safety profiles of the ICS components in the two more frequently used ICS/LABA combinations (budesonide/formoterol and fluticasone/salmeterol) for the management of COPD...
February 2015: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25366745/roles-of-beta2-adrenergic-receptor-gene-polymorphisms-in-a-turkish-population-with-obstructive-sleep-apnea-syndrome-or-obesity
#19
I Gök, I Celebi, N Hüseyinoğlu, C Ozic
We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral blood samples were taken from patients diagnosed with obstructive sleep apnea by polysomnography. DNA was extracted from blood samples and amplified using polymerase chain reaction...
2014: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25322575/-the-expression-and-significance-of-beta2-ar-and-vegfr-2-in-infantile-hemangioma
#20
Guangqi Xu, Jingjing Niu, Renrong Lyu, Shengru Zhou, Ran Huo
OBJECTIVE: To investigate the significance of beta-adrenergic receptor 2 (beta2-AR) and vascular endothelial growth factor-2 (VEGFR-2) in the occurrence and development of infantile hemangioma through detecting the expression of beta2-AR and VEGFR-2 in the different stages of infantile hemangiomas. METHODS: According to the Mulliken's classification standard, we classified the specimens as proliferating group (32 cases), involuting group (17 cases) and involuted group (11 cases)...
July 2014: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
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