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Mild behavioral impairment

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https://www.readbyqxmd.com/read/27923640/the-accumulation-of-brain-injury-leads-to-severe-neuropathological-and-neurobehavioral-changes-after-repetitive-mild-traumatic-brain-injury
#1
Huabin Gao, Zhaoli Han, Ruojing Bai, Shan Huang, Xintong Ge, Fanglian Chen, Ping Lei
Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of accumulation play an important role in the neurodegenerative disease is still unknown. We utilized the Sprague Dawley (SD) rats to develop the animal models of repetitive mild TBI and single mild TBI in order to detect the neurobehavioral changes...
December 3, 2016: Brain Research
https://www.readbyqxmd.com/read/27922638/enhancing-dopaminergic-signaling-and-histone-acetylation-promotes-long-term-rescue-of-deficient-fear-extinction
#2
N Whittle, V Maurer, C Murphy, J Rainer, D Bindreither, M Hauschild, A Scharinger, M Oberhauser, T Keil, C Brehm, T Valovka, J Striessnig, N Singewald
Extinction-based exposure therapy is used to treat anxiety- and trauma-related disorders; however, there is the need to improve its limited efficacy in individuals with impaired fear extinction learning and to promote greater protection against return-of-fear phenomena. Here, using 129S1/SvImJ mice, which display impaired fear extinction acquisition and extinction consolidation, we revealed that persistent and context-independent rescue of deficient fear extinction in these mice was associated with enhanced expression of dopamine-related genes, such as dopamine D1 (Drd1a) and -D2 (Drd2) receptor genes in the medial prefrontal cortex (mPFC) and amygdala, but not hippocampus...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27917121/neurochemical-and-neuroanatomical-plasticity-following-memory-training-and-yoga-interventions-in-older-adults-with-mild-cognitive-impairment
#3
Hongyu Yang, Amber M Leaver, Prabha Siddarth, Pattharee Paholpak, Linda Ercoli, Natalie M St Cyr, Harris A Eyre, Katherine L Narr, Dharma S Khalsa, Helen Lavretsky
Behavioral interventions are becoming increasingly popular approaches to ameliorate age-related cognitive decline, but their underlying neurobiological mechanisms and clinical efficiency have not been fully elucidated. The present study explored brain plasticity associated with two behavioral interventions, memory enhancement training (MET) and a mind-body practice (yogic meditation), in healthy seniors with mild cognitive impairment (MCI) using structural magnetic resonance imaging (s-MRI) and proton magnetic resonance spectroscopy ((1)H-MRS)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27916420/potential-involvement-of-jnk1-repression-in-the-hepatic-effect-of-sitagliptin-and-metformin-in-rats-subjected-to-high-fat-diet-and-chronic-mild-distress
#4
Yosra M Magdy, Omnyah A El-Kharashi, Enas S Nabih, Safaa M Shaker, Lobna F Abd-Elaziz, Sawsan Aboul-Fotouh
BACKGROUND: Depression and non-alcoholic steatohepatitis (NASH) are highly co-morbid, and hepatic JNK pathway may be involved in their relation. AIM: To evaluate the impact of depression on NASH through the involvement of JNK1 and to assess the effect of sitagliptin and metformin on hepatic JNK1 expression in both NASH and NASH associated with depression. METHODS: Eight groups of male Wistar rats were used: naïve rats, non-stressed NASH, non-stressed NASH sitagliptin treated, non-stressed NASH metformin treated, stressed, stressed NASH untreated, stressed NASH sitagliptin treated and stressed NASH metformin treated...
December 1, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27911316/risk-factors-for-mild-cognitive-impairment-in-german-primary-care-practices
#5
Louis Jacob, Jens Bohlken, Karel Kostev
BACKGROUND: Mild cognitive impairment (MCI) is a common mental disorder affecting around 16% of elderly people without dementia. MCI is considered an intermediate state between normal cognition and dementia. OBJECTIVE: To analyze risk factors for the development of MCI in German primary care practices. METHODS: In total, 3,604 MCI patients and 3,604 controls without MCI were included between January 2010 and December 2015. Several disorders potentially associated with MCI were determined...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27901414/cognitive-deficits-and-inflammatory-response-resulting-from-mild-to-moderate-traumatic-brain-injury-in-rats-are-exacerbated-by-repeated-pre-exposure-to-an-innate-stress-stimulus
#6
Michaël Ogier, Amor Belmeguenai, Thomas Lieutaud, Béatrice Georges, Sandrine Bouvard, Emilie Carré, Frédéric Canini, Laurent Bezin
Traumatic brain injury (TBI) is common in both military and civilian populations, and often results in neurobehavioral sequelae that impair quality of life in both patients and their family. Although individuals who are chronically exposed to stress are more likely to experience TBI, it is still unknown whether pre-injury stress influences the outcome after TBI. The present study tested whether behavioral and cognitive long-term outcome after TBI in rats is affected by prior exposure to an innate stress stimulus...
November 30, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27901345/effects-of-environmental-enrichment-on-behavioral-and-spatial-cognitive-deficits-in-morphine-dependent-and-withdrawn-rats
#7
Arezoo Hammami-Abrand Abadi, Hossein Miladi-Gorji
This study was designed to examine the effect of environmental enrichment during morphine dependence and withdrawal on morphine-induced behavioral and spatial cognitive disorders in morphine-withdrawn rats. Adult male Wistar rats (190 ± 20 g) were injected with bi-daily doses (10 mg/kg, 12 h intervals) of morphine for 14 days. Rats were reared in SE or EE during the development of dependence on morphine and withdrawal. Then, rats were tested for spatial learning and memory (the water maze), spontaneous withdrawal signs, and grooming behavior...
September 19, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27887597/technology-enhanced-multi-domain-at-home-continuum-of-care-program-with-respect-to-usual-care-for-people-with-cognitive-impairment-the-ability-telerehabilitation-study-protocol-for-a-randomized-controlled-trial
#8
O Realdon, F Rossetto, M Nalin, I Baroni, M Cabinio, R Fioravanti, F L Saibene, M Alberoni, F Mantovani, M Romano, R Nemni, F Baglio
BACKGROUND: According to the World Alzheimer Report (Prince, The Global Impact of Dementia: an Analysis of Prevalence, Incidence, Cost and Trends, 2015), 46.8 million people worldwide are nowadays living with dementia. And this number is estimated to approximate 131.5 million by 2050, with an increasing burden on society and families. The lack of medical treatments able to stop or slow down the course of the disease has moved the focus of interest toward the nonpharmacological approach and psychosocial therapies for people with/at risk of dementia, as in the Mild Cognitive Impairment (MCI) condition...
November 25, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27886529/autobiographical-and-episodic-memory-deficits-in-mild-traumatic-brain-injury
#9
Jeffrey D Wammes, Tyler J Good, Myra A Fernandes
Those who have suffered a concussion, otherwise known as a mild traumatic brain injury (mTBI), often complain of lingering memory problems. However, there is little evidence in the behavioral literature reliably demonstrating memory deficits. Thus, in the present study, cognitive profiles including measures of general executive functioning and processing speed, as well as episodic and semantic memory were collected in younger and older adult participants with or without a remote (>1year prior to testing) mTBI...
November 22, 2016: Brain and Cognition
https://www.readbyqxmd.com/read/27884130/a-profile-of-the-clinical-course-of-cognition-and-comorbidity-in-mild-cognitive-impairment-and-dementia-study-the-4c-study-two-complementary-longitudinal-clinical-cohorts-in-the-netherlands
#10
Weiqi Liao, Renske E G Hamel, Marcel G M Olde Rikkert, Saskia M Oosterveld, Pauline Aalten, Frans R J Verhey, Philip Scheltens, Nicole Sistermans, Yolande A L Pijnenburg, Wiesje M van der Flier, Inez H G B Ramakers, René J F Melis
BACKGROUND: Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mechanisms causing this heterogeneity. In addition to correlates of the disorder, patient characteristics such as their health status, social environment, comorbidities and frailty may contribute to variability in trajectories over time. The current paper outlines the study design and the study population of and provides an overview of the data collected in the Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment (4C-MCI cohort, n = 315) and Dementia (4C-Dementia cohort, n = 331) Study...
November 25, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27875580/inescapable-stress-changes-walking-behavior-in-flies-learned-helplessness-revisited
#11
Sophie Batsching, Reinhard Wolf, Martin Heisenberg
Like other animals flies develop a state of learned helplessness in response to unescapable aversive events. To show this, two flies, one 'master', one 'yoked', are each confined to a dark, small chamber and exposed to the same sequence of mild electric shocks. Both receive these shocks when the master fly stops walking for more than a second. Behavior in the two animals is differently affected by the shocks. Yoked flies are transiently impaired in place learning and take longer than master flies to exit from the chamber towards light...
2016: PloS One
https://www.readbyqxmd.com/read/27870441/sexual-divergence-in-activity-dependent-neuroprotective-protein-impacting-autism-schizophrenia-and-alzheimer-s-disease
#12
REVIEW
Illana Gozes
Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) interacts with key regulatory proteins, including the chromatin remodeling complex SWI/SNF, proteins associated with RNA splicing, RNA translation, microtubule dynamics, and autophagy. ADNP regulates > 400 genes during mouse embryonic development and is essential for neural tube closure. ADNP key functions extend from mice to men, with mutations causing ADNP-related ID/autism syndrome, also known as the Helsmoortel-Van der Aa syndrome...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27864043/maternal-trans-fat-intake-during-pregnancy-or-lactation-impairs-memory-and-alters-bdnf-and-trkb-levels-in-the-hippocampus-of-adult-offspring-exposed-to-chronic-mild-stress
#13
Camila Simonetti Pase, Karine Roversi, Katiane Roversi, Luciana Taschetto Vey, Verônica Tironi Dias, Juliana Cristiana Veit, Luana Haselein Maurer, Thiago Duarte, Tatiana Emanuelli, Marta Duarte, Marilise Escobar Bürger
This study aimed to assess the influence of maternal dietary fat intake during pregnancy or lactation on memory of adult offspring after chronic mild stress (CMS) exposure. Female Wistar rats were supplemented daily with soybean oil/fish oil (SO/FO) or hydrogenated vegetable fat (HVF) by oral gavage (3.0g/kg body weight) during pregnancy or lactation. On post-natal day (PND) 60, half of the animals were exposed to CMS following behavioral assessments. While the adult offspring born under influence of SO/FO and HVF supplementations during pregnancy showed higher levels of n-3 and n-6 fatty acids (FA) series DHA and ARA metabolites, respectively, in the hippocampus, adult offspring born from supplemented dams during lactation showed higher levels of their precursors: ALA and LA...
November 15, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27851899/cognitive-ability-in-down-syndrome-and-its-relationship-to-urinary-neopterin-a-marker-of-activated-cellular-immunity
#14
Panagiotis Zis, André Strydom, David Buckley, Daniel Adekitan, Patrick C McHugh
BACKGROUND: Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS). METHODS: Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS)...
November 13, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27845292/effects-of-selective-cholinergic-and-gabaergic-lesions-of-the-nucleus-basalis-magnocellularis-on-place-or-responce-learning-in-plus-shaped-maze
#15
L Kruashvili, M Demurishvili, M Burjanadze, M Dashniani, G Beselia
In the present study we evaluated effects of selective cholinergic or GABAergic lesions of the nucleus basalis magnocellularis (NBM) using immunotxins 192 IgG-saporin and GAT1-SAP on place and response learning in plus-shaped maze. In current behavioral paradigm rats learned food-rewarded mazes that were efficiently learned using either place or turning strategies. A histological evaluation indicated that 192 IgG-saporin lesions specifically depleted cholinergic neurons but did not result in noticeable damage to the GABAergic cells within NBM...
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27834286/mild-visual-impairment-and-its-impact-on-self-care-among-older-adults
#16
Rachel O'Conor, Samuel G Smith, Laura M Curtis, Julia Yoshino Benavente, Daniel P Vicencio, Michael S Wolf
OBJECTIVE: To determine the prevalence of mild visual impairment (MVI) among urban older adults in primary care settings, and ascertain whether MVI was a risk factor for inadequate performance on self-care health tasks. METHOD: We used data from a cohort of 900 older adults recruited from primary care clinics. Self-management skills were assessed using the Comprehensive Health Activities Scale, and vision with corrective lenses was assessed with the Snellen. We modeled visual acuity predicting health task performance with linear regression...
November 10, 2016: Journal of Aging and Health
https://www.readbyqxmd.com/read/27833549/impaired-white-matter-connections-of-the-limbic-system-networks-associated-with-impaired-emotional-memory-in-alzheimer-s-disease
#17
Xiaoshu Li, Haibao Wang, Yanghua Tian, Shanshan Zhou, Xiaohu Li, Kai Wang, Yongqiang Yu
Background: Discrepancies persist regarding retainment of emotional enhancement of memory (EEM) in mild cognitive impairment (MCI) and early Alzheimer's disease (AD) patients.In addition, the neural mechanisms are still poorly understood, little is known about emotional memory related changes in white matter (WM). Objective: To observe whether EEM is absent in amnestic MCI (aMCI) and AD patients, and to investigate if emotional memory is associated with WM connections and gray matters (GM) of the limbic system networks...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27832354/neuropsychological-improvement-after-posterior-fossa-arachnoid-cyst-drainage
#18
M L Cuny, M Pallone, H Piana, N Boddaert, C Sainte-Rose, L Vaivre-Douret, P Piolino, S Puget
PURPOSE: Posterior fossa arachnoid cysts (PFAC) are mostly considered as benign lesions of the cerebellum. Although many studies have shown the major role of the cerebellum in modulating movement, language, cognition, and social interaction, there are few studies on the cognitive impact and surgical decompression of PFAC. METHODS: We present the cases of two brothers successively diagnosed with PFAC and neuropsychological delay. After multidisciplinary discussion with the boys' parents, it was decided to drain these lesions...
November 10, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27831731/behavioral-inhibition-and-activation-systems-in-traumatic-brain-injury
#19
Christina G Wong, Lisa J Rapport, Sarah-Jane Meachen, Robin A Hanks, Mark A Lumley
PURPOSE/OBJECTIVE: Personality has been linked to cognitive appraisal and health outcomes; however, research specific to traumatic brain injury (TBI) has been sparse. Gray's theory of behavioral inhibition system and behavioral activation system (BIS/BAS) offers a neurobiologic view of personality that may be especially relevant to neurobehavioral change associated with TBI. The present study examined theoretical and psychometric issues of using the BIS/BAS scale among adults with TBI as well as BIS/BAS personality correlates of TBI...
November 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27826103/longer-hypoxia-ischemia-periods-to-neonatal-rats-causes-motor-impairments-and-muscular-changes
#20
L E Durán-Carabali, E F Sanches, M R Marques, D Aristimunha, A Pagnussat, C A Netto
Prematurity and hypoxia-ischemia (HI) can lead to movement disorders in infants. Considering that mild-moderate HI induced at postnatal day (PND) 3 has failed to produce motor disabilities similar to those seen in pre-term newborns, the main goal of the present study was to verify whether longer hypoxia periods would mimic motor function impairment, brain and muscle morphological alterations. Forty-nine Wistar rat pups of both sexes were randomly assigned to surgical control (CG) and HI groups. HI animals were submitted to the Levine-Rice model at PND 3, and exposed to 120 (HI-120'), 180 (HI-180') or 210 (HI-210') minutes of hypoxia (FiO2: 0...
November 5, 2016: Neuroscience
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