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Mild behavioral impairment

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https://www.readbyqxmd.com/read/29669906/cortical-and-subcortical-gray-matter-bases-of-cognitive-deficits-in-rem-sleep-behavior-disorder
#1
Shady Rahayel, Ronald B Postuma, Jacques Montplaisir, Daphné Génier Marchand, Frédérique Escudier, Malo Gaubert, Pierre-Alexandre Bourgouin, Julie Carrier, Oury Monchi, Sven Joubert, Frédéric Blanc, Jean-François Gagnon
OBJECTIVE: To investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI). METHODS: Fifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3-tesla MRI acquisition of T1 anatomical images...
April 18, 2018: Neurology
https://www.readbyqxmd.com/read/29665077/gliovascular-changes-precede-white-matter-damage-and-long-term-disorders-in-juvenile-mild-closed-head-injury
#2
Beatriz Rodriguez-Grande, Andre Obenaus, Aleksandra Ichkova, Justine Aussudre, Thomas Bessy, Elodie Barse, Bassem Hiba, Gwénaëlle Catheline, Grégory Barrière, Jerome Badaut
Traumatic brain injury (TBI) is a leading cause of hospital visits in pediatric patients and often leads to long-term disorders even in cases of mild severity. White matter (WM) alterations are commonly observed in patients months or years after the injury assessed by magnetic resonance imaging (MRI), but little is known about WM pathophysiology early after mild pediatric TBI. To evaluate the status of the gliovascular unit in this context, mild TBI was induced in postnatal-day 17 mice using a closed head injury model with two grades of severity (G1, G2)...
April 17, 2018: Glia
https://www.readbyqxmd.com/read/29659622/the-association-of-single-and-combined-factors-of-sedentary-behavior-and-physical-activity-with-subjective-cognitive-complaints-among-community-dwelling-older-adults-cross-sectional-study
#3
Yuta Nemoto, Shinichiro Sato, Masaki Takahashi, Noriko Takeda, Munehiro Matsushita, Yoshinori Kitabatake, Kazushi Maruo, Takashi Arao
Subjective cognitive complaints (SCC) might be a meaningful indicator of dementia onset or mild cognitive impairment, and identifying the related factors of SCC could contribute to preventing these diseases. However, the relationship between SCC and lifestyle factors remains largely unproven. The purpose of this study was to examine the association of type of sedentary behavior, physical activity, or their combination with SCC among community-dwelling older adults. In 2016, 6677 community-living elderly were recruited to participate in a survey investigating cognition, physical activity, and sedentary behavior...
2018: PloS One
https://www.readbyqxmd.com/read/29656013/escitalopram-alleviates-stress-induced-alzheimer-s-disease-like-tau-pathologies-and-cognitive-deficits-by-reducing-hypothalamic-pituitary-adrenal-axis-reactivity-and-insulin-gsk-3%C3%AE-signal-pathway-activity
#4
Chao Wu, Wei-Gang Gong, Yan-Juan Wang, Jun-Jun Sun, Hong Zhou, Zhi-Jun Zhang, Qing-Guo Ren
Chronic stress, a causal factor for depression, can also cause cognitive impairments and tau pathology. However, whether and how the selective serotonin reuptake inhibitor antidepressant escitalopram ameliorates these effects are still unclear. In the present study, rats were subjected to chronic mild unpredictable stress for 8 weeks. Following the initial 4 weeks, the stressed animals were separated into susceptible (depressive) and unsusceptible (resistant) groups based on behavioral tests. Then, escitalopram (10 mg/kg i...
March 19, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29648487/bdnf-expression-increases-without-changes-in-play-behavior-following-concussion-in-juvenile-rats-rattus-norvegicus-brief-report
#5
Allison C F Dyck, Tammy L Ivanco
PURPOSE: Young children have a high risk of concussion or mild traumatic brain injury (mTBI). Children often appear healthy soon after mTBI, but some have pervasive cognitive and/or motor impairments. Understanding underlying mechanisms recruited after concussion may help for return to play protocols and mitigating what might be lifelong impairments. METHODS: We investigated molecular and behavioral changes in a rat model of childhood concussion. Rats received an injury or sham procedure at an age approximately equivalent to the human period of early childhood...
April 12, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29643258/prevalence-of-poststroke-neurocognitive-disorders-using-national-institute-of-neurological-disorders-and-stroke-canadian-stroke-network-vascog-criteria-vascular-behavioral-and-cognitive-disorders-and-optimized-criteria-of-cognitive-deficit
#6
Mélanie Barbay, Hervé Taillia, Claudine Nédélec-Ciceri, Flavie Bompaire, Camille Bonnin, Jérôme Varvat, Françoise Grangette, Momar Diouf, Emmanuel Wiener, Jean-Louis Mas, Martine Roussel, Olivier Godefroy
BACKGROUND AND PURPOSE: The prevalence of poststroke neurocognitive disorder (NCD) has yet to be accurately determined. The primary objective of the present study was to optimize operationalization of the criterion for NCD by using an external validity criterion. METHODS: The GRECOG-VASC cohort (Groupe de Réflexion pour l'Évaluation Cognitive Vasculaire) of 404 stroke patients with cerebral infarct (91.3%) or hemorrhage (18.7%) was assessed 6 months poststroke and 1003 healthy controls, with the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network standardized battery...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29628029/-mild-behavioral-impairment-a-new-concept-for-the-prodromic-phases-of-dementia
#7
Luis Agüera Ortiz, Jorge López Álvarez
Neuropsychiatric symptoms (NPS) are frequent in dementia. These symptoms are also present in patients with mild cognitive impairment (MCI) and can even constitute the first manifestations of a neurodegenerative process, preceding the development of cognitive symptoms. The presence of NPS is associated with higher rates of conversion to dementia in healthy persons and patients with MCI. Recognizing the importance of NPS, the Alzheimer Association created a working group that has designed the ISTAART criteria for mild behavioral impairment (MBI), including the following areas of assessment: motivation, affect, impulse control, social appropriateness and thoughts/perception...
June 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29614645/structural-anatomical-investigation-of-long-term-memory-deficit-in-behavioral-frontotemporal-dementia
#8
Maxime Bertoux, Emma C Flanagan, Matthew Hobbs, Amparo Ruiz-Tagle, Carolina Delgado, Marcelo Miranda, Agustín Ibáñez, Andrea Slachevsky, Michael Hornberger
Although a growing body of work has shown that behavioral variant frontotemporal dementia (bvFTD) could present with severe amnesia in approximately half of cases, memory assessment is currently the clinical standard to distinguish bvFTD from Alzheimer's disease (AD). Thus, the concept of "relatively preserved episodic memory" in bvFTD remains the basis of its clinical distinction from AD and a criterion for bvFTD's diagnosis. This view is supported by the idea that bvFTD is not characterized by genuine amnesia and hippocampal degeneration, by contrast to AD...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614644/visual-processing-during-short-term-memory-binding-in-mild-alzheimer-s-disease
#9
Gerardo Fernández, David Orozco, Osvaldo Agamennoni, Marcela Schumacher, Silvana Sañudo, Juan Biondi, Mario A Parra
Patients with Alzheimer's disease (AD) typically present with attentional and oculomotor abnormalities that can have an impact on visual processing and associated cognitive functions. Over the last few years, we have witnessed a shift toward the analyses of eye movement behaviors as a means to further our understanding of the pathophysiology of common disorders such as AD. However, little work has been done to unveil the link between eye moment abnormalities and poor performance on cognitive tasks known to be markers for AD patients, such as the short-term memory-binding task...
March 29, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29604987/neuroaids-in-children
#10
Jo M Wilmshurst, Charles K Hammond, Kirsty Donald, Jacqueline Hoare, Karen Cohen, Brian Eley
The human immunodeficiency virus-1 (HIV-1) enters the central nervous system compartment within the first few weeks of systemic HIV infection and may cause a spectrum of neurologic complications. Without combination antiretroviral therapy (cART), 50-90% of all HIV-infected infants and children develop some form of neuroAIDS. Of the estimated 2.3 million children less than 15 years of age who were living in sub-Saharan Africa at the end of 2014, only 30% were receiving cART, suggesting that there is a large burden of neuroAIDS among HIV-infected children in sub-Saharan Africa...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29604978/neuropathogenesis-of-human-immunodeficiency-virus-infection
#11
Brady Sillman, Christopher Woldstad, Joellyn Mcmillan, Howard E Gendelman
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) remain a common end-organ manifestation of viral infection. Subclinical and mild symptoms lead to neurocognitive and behavioral abnormalities. These are associated, in part, with viral penetrance and persistence in the central nervous system. Infections of peripheral blood monocytes, macrophages, and microglia are the primary drivers of neuroinflammation and neuronal impairments. While current antiretroviral therapy (ART) has reduced the incidence of HIV-associated dementia, milder forms of HAND continue...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29603867/delineating-the-psychiatric-and-behavioral-phenotype-of-recurrent-2q13-deletions-and-duplications
#12
Kate Wolfe, Andrew McQuillin, Viola Alesi, Elise Boudry Labis, Peter Cutajar, Bruno Dallapiccola, Maria Lisa Dentici, Anne Dieux-Coeslier, Benedicte Duban-Bedu, Tina Duelund Hjortshøj, Himanshu Goel, Sara Loddo, Deborah Morrogh, Anne-Laure Mosca-Boidron, Antonio Novelli, Laurence Olivier-Faivre, Jennifer Parker, Michael J Parker, Christine Patch, Anna L Pelling, Thomas Smol, Zeynep Tümer, Olivier Vanakker, Arie van Haeringen, Clémence Vanlerberghe, Andre Strydom, David Skuse, Nick Bass
Recurrent deletions and duplications at the 2q13 locus have been associated with developmental delay (DD) and dysmorphisms. We aimed to undertake detailed clinical characterization of individuals with 2q13 copy number variations (CNVs), with a focus on behavioral and psychiatric phenotypes. Participants were recruited via the Unique chromosomal disorder support group, U.K. National Health Service Regional Genetics Centres, and the DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) database...
March 31, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29603201/pr-957-mediates-neuroprotection-by-inhibiting-th17-differentiation-and-modulating-cytokine-production-in-a-mouse-model-of-ischemic-stroke
#13
Ying Guo, Xiuju Chen, Daojing Li, Haijie Liu, Yanan Ding, Ranran Han, Yanchao Shi, Xiaofeng Ma
Acute ischemic stroke can induce secondary brain injury by activating an inflammatory response that contributes to clinical impairment. As a specific inhibitor of the immunoproteasome subunit low molecular weight polypeptide 7 (LMP7), PR-957 may participate in regulating pathophysiologic and inflammatory responses in multiple diseases of the CNS. We investigated the neuroprotective properties of PR-957 in a mouse model of stroke, induced by middle cerebral artery occlusion (MCAO). After MCAO and injections of PR-957 or vehicle, we evaluated mice behaviorally using modified Neurological Severity Scores (mNSS) and sensorimotor tests, including the adhesive-removal test, a foot-fault test, and an inclined plane test...
March 30, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29569150/impaired-lipid-metabolism-markers-to-assess-the-risk-of-neuroinflammation-in-autism-spectrum-disorder
#14
Hanan Qasem, Laila Al-Ayadhi, Geir Bjørklund, Salvatore Chirumbolo, Afaf El-Ansary
Autism spectrum disorder (ASD) is a multifactorial disorder caused by an interaction between environmental risk factors and a genetic background. It is characterized by impairment in communication, social interaction, repetitive behavior, and sensory processing. The etiology of ASD is still not fully understood, and the role of neuroinflammation in autism behaviors needs to be further investigated. The aim of the present study was to test the possible association between prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1), prostaglandin PGE2 EP2 receptors and nuclear kappa B (NF-κB) and the severity of cognitive disorders, social impairment, and sensory dysfunction...
March 22, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29567621/diet-matters-glucocorticoid-related-neuroadaptations-associated-with-calorie-intake-in-female-rhesus-monkeys
#15
Jodi R Godfrey, Maylen Perez Diaz, Melanie Pincus, Zsofia Kovacs-Balint, Eric Feczko, Eric Earl, Oscar Miranda-Dominguez, Damien Fair, Mar M Sanchez, Mark E Wilson, Vasiliki Michopoulos
Exposure to psychosocial stressors increases consumption of palatable, calorically dense diets (CDD) and the risk for obesity, especially in females. While consumption of an obesogenic diet and chronic stress have both been shown to decrease dopamine 2 receptor (D2R) binding and alter functional connectivity (FC) within the prefrontal cortex (PFC) and the nucleus accumbens (NAcc), it remains uncertain how social experience and dietary environment interact to affect reward pathways critical for the regulation of motivated behavior...
March 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29554838/caregiver-reported-sleep-disturbances-are-associated-with-behavioral-and-psychological-symptoms-in-an-asian-elderly-cohort-with-cognitive-impairment-no-dementia
#16
Xin Xu, Cheuk Ni Kan, Tien Yin Wong, Ching-Yu Cheng, M Kamran Ikram, Christopher Li-Hsian Chen, Narayanaswamy Venketasubramanian
OBJECTIVE: Sleep disturbances were found to be associated with more behavioral and psychological symptoms (BPS) in early patients with Alzheimer's disease (AD). However, data on preclinical stages of dementia are lacking. Hence, the present study sought to investigate the association between sleep disturbances and BPS in dementia-free elderly with varying severity of cognitive impairment in an Asian sample. METHODS: Community-living elderly were recruited and administered a comprehensive cognitive battery (vascular dementia battery [VDB]) and the Neuropsychiatric Inventory to assess symptoms of sleep disturbances and BPS...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29545742/tau-depletion-in-app-transgenic-mice-attenuates-task-related-hyperactivation-of-the-hippocampus-and-differentially-influences-locomotor-activity-and-spatial-memory
#17
Misato Yoshikawa, Yoshiyuki Soeda, Makoto Michikawa, Osborne F X Almeida, Akihiko Takashima
Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and inhibition, is found in patients with mild cognitive impairment, a prodromal stage of Alzheimer's disease (AD). To better understand the relationship between hippocampal hyperactivity and the molecular triggers of behavioral impairments in AD, we used Mn-enhanced MRI (MEMRI) to assess neuronal activity after subjecting mice to a task requiring spatial learning and memory. Depletion of endogenous tau in an amyloid precursor protein (APP) transgenic (J20) mouse line was shown to ameliorate hippocampal hyperactivity in J20 animals, tau depletion failed to reverse memory deficits associated with APP/Aβ overproduction...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29530367/rbd-a-red-flag-for-cognitive-impairment-in-parkinson-s-disease
#18
REVIEW
Yi-Qi Lin, Sheng-Di Chen
Increasing evidence indicates a strong association between rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease - cognitive impairment (PD-CI). Numerous longitudinal and cross-sectional studies have shown that RBD may be an important risk factor and predictor of Parkinson's disease - mild cognitive impairment (PD-MCI) and Parkinson's disease dementia (PDD); which may be explained by the association of mechanisms between RBD and PD-CI, including neurotransmitter alterations, genetic mutation, neuroinflammation, alpha-synuclein inclusion, abnormal cerebral metabolism and cortical activity slowing...
April 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29528693/interaction-between-memory-impairment-and-depressive-symptoms-can-exacerbate-anosognosia-a-comparison-of-alzheimer-s-disease-with-mild-cognitive-impairment
#19
Hikaru Oba, Teruyuki Matsuoka, Ayu Imai, Hiroshi Fujimoto, Yuka Kato, Keisuke Shibata, Kaeko Nakamura, Jin Narumoto
OBJECTIVE: To investigate the effects of interactions between memory impairment, depressive symptoms, and anosognosia. METHODS: Anosognosia for memory impairment was assessed in 118 patients with Alzheimer's disease (AD), 47 patients with mild cognitive impairment (MCI), and 17 non-diagnosed controls (NC) using a questionnaire and evaluation of the anosognosia score as the discrepancy between ratings of the patient and a relative. Demographic characteristics, such as the relationship of the patient with the relative and the activities of daily living (ADL) were evaluated...
March 12, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29527475/an-acute-bout-of-aerobic-or-strength-exercise-specifically-modifies-circulating-exerkine-levels-and-neurocognitive-functions-in-elderly-individuals-with-mild-cognitive-impairment
#20
Chia-Liang Tsai, Jozef Ukropec, Barbara Ukropcová, Ming-Chyi Pai
Although exercise is an effective way to decrease the risk of developing Alzheimer's disease, the biological basis for such benefits from the different exercise modes remains elusive. The present study thus aimed (i) to investigate the effects of acute aerobic or resistance exercise on neurocognitive performances and molecular markers when performing a cognitive task involving executive functioning in older adults with amnestic mild cognitive impairment (aMCI), and (ii) to explore relationships of acute exercise-induced neurocognitive changes with changes in circulating levels of neuroprotective growth factors (e...
2018: NeuroImage: Clinical
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