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conjugated linolic acid

Jin-Kyoung Yang, Eunjin Lee, In-Jun Hwang, DaBin Yim, Juhee Han, Yoon-Sik Lee, Jong-Ho Kim
The regulation of tyrosinase activity and reactive oxygen species is of great importance for the prevention of dermatological disorders in the fields of medicine and cosmetics. Herein, we report a strategy based on solid-phase peptide chemistry for the synthesis of β-lactoglobulin peptide fragment/caffeic acid (CA) conjugates (CA-Peps) with dual activities of tyrosinase inhibition and antioxidation. The purity of the prepared conjugates, CA-MHIR, CA-HIRL, and CA-HIR significantly increased to 99%, as acetonide-protected CA was employed in solid-phase coupling reactions on Rink amide resins...
March 13, 2018: Bioconjugate Chemistry
Laura-Isobel McCall, Anupriya Tripathi, Fernando Vargas, Rob Knight, Pieter C Dorrestein, Jair L Siqueira-Neto
Trypanosoma cruzi parasites are the causative agents of Chagas disease. These parasites infect cardiac and gastrointestinal tissues, leading to local inflammation and tissue damage. Digestive Chagas disease is associated with perturbations in food absorption, intestinal traffic and defecation. However, the impact of T. cruzi infection on the gut microbiota and metabolome have yet to be characterized. In this study, we applied mass spectrometry-based metabolomics and 16S rRNA sequencing to profile infection-associated alterations in fecal bacterial composition and fecal metabolome through the acute-stage and into the chronic stage of infection, in a murine model of Chagas disease...
March 12, 2018: PLoS Neglected Tropical Diseases
T Y Zhang, J T Huang, H B Tian, Y Ma, Z Chen, J J Wang, H P Shi, J Luo
The trans-10,cis-12 isomer of conjugated linoleic acid (t10c12-CLA) is a biohydrogenation intermediate in the rumen and has been shown to cause milk fat depression in dairy goats. However, few studies have focused on the in vitro molecular mechanisms involved in the response of the goat mammary gland to t10c12-CLA. In the present study, RNA sequencing technology was used to investigate the effects of t10c12-CLA on goat mammary epithelial cells. From the data, 25,153 annotated transcripts were obtained, and differentially expressed genes were selected based on a false discovery rate <0...
March 7, 2018: Journal of Dairy Science
V L N Brandao, X Dai, E M Paula, L G Silva, M I Marcondes, T Shenkoru, S R Poulson, A P Faciola
Camelina is a drought- and salt-tolerant oil seed, which in total ether extract (EE) contains up to 74% polyunsaturated fatty acids. The objective of this study was to assess the effects of replacing calcium salts of palm oil (Megalac, Church & Dwight Co. Inc., Princeton, NJ) with camelina seed (CS) on ruminal fermentation, digestion, and flows of fatty acids (FA) and AA in a dual-flow continuous culture system when supplemented at 5 or 8% dietary EE. Diets were randomly assigned to 8 fermentors in a 2 × 2 factorial arrangement of treatments in a replicated 4 × 4 Latin square design, with four 10-d experimental periods consisting of 7 d for diet adaptation and 3 d for sample collection...
March 7, 2018: Journal of Dairy Science
Giuliana Muzio, Marta Miola, Sara Ferraris, Marina Maggiora, Elisa Bertone, Maria Paola Puccinelli, Marina Ricci, Ester Borroni, Rosa Angela Canuto, Enrica Verné, Antonia Follenzi
No abstract text is available yet for this article.
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Katarzyna Turek, Jacek Domagała, Monika Wszołek
BACKGROUND: Yogurt is a dairy product with a high nutritional value. However, like all milk products, it contains milk fat and is rich in saturated fatty acids. It would be desirable to enrich dairy products in poly- unsaturated fatty acids to increase dietary intake amongst consumers and improve their health. Also, some LAB bacteria are able to produce CLA and CLnA isomers from linoleic and linolenic acids. The aim of this study was to investigate the chemical properties and fatty acid profile of yogurt with the addition of 3...
January 2018: Acta Scientiarum Polonorum. Technologia Alimentaria
Tarek A Morsy, Ahmed E Kholif, Osama H Matloup, Amgad Abu Elella, Uchenna Y Anele, Joel S Caton
The experiments reported in this Research Paper aimed to study the effects of mustard and cumin seeds inclusion on feed utilisation, milk production, composition, and profile of milk fatty acids in lactating Damascus goats. The study was a completely randomised design with repeated measurements in time using fifteen goats (6 ± 2 d of lactation) divided into 3 treatments (5 goats per treatment). Goats were offered a control diet of berseem clover and concentrates (1 : 1 dry matter (DM) basis) or the control diet supplemented with either 10 g/d of dried mustard seeds (mustard treatment) or 10 g/d of cumin seeds (cumin treatment) for 12 weeks...
February 26, 2018: Journal of Dairy Research
G J Kolling, S C B Stivanin, A M Gabbi, F S Machado, A L Ferreira, M M Campos, T R Tomich, C S Cunha, S W Dill, L G R Pereira, V Fischer
Plant extracts have been proposed as substitutes for chemical feed additives due to their potential as rumen fermentation modifiers and because of their antimicrobial and antioxidant activities, possibly reducing methane emissions. This study aimed to evaluate the use of oregano (OR), green tea extracts (GT), and their association as feed additives on the performance and methane emissions from dairy between 28 and 87 d of lactation. Thirty-two lactating dairy cows, blocked into 2 genetic groups: 16 Holstein cows and 16 crossbred Holstein-Gir, with 522...
February 21, 2018: Journal of Dairy Science
Lourdes Santiago-López, Jose E Aguilar-Toalá, Adrián Hernández-Mendoza, Belinda Vallejo-Cordoba, Andrea M Liceaga, Aarón F González-Córdova
Traditionally, cheese is manufactured by converting fluid milk to a semisolid mass through the use of a coagulating agent, such as rennet, acid, heat plus acid, or a combination thereof. Cheese can vary widely in its characteristics, including color, aroma, texture, flavor, and firmness, which can generally be attributed to the production technology, source of the milk, moisture content, and length of aging, in addition to the presence of specific molds, yeast, and bacteria. Among the most important bacteria, lactic acid bacteria (LAB) play a critical role during the cheese-making process...
February 21, 2018: Journal of Dairy Science
Shengdi Li, Ziyi Chang, Tianqing Zhu, Yixue Li, Bruce A Freeman, Y Eugene Chen, Jifeng Zhang
Nitro-conjugated linoleic acid (NO2 -CLA) is formed by metabolic and inflammatory reactions of nitric oxide and nitrite, and represents the most abundant nitro-fatty acid species in humans. These electrophilic fatty acid nitroalkene derivatives mediate pleiotropic cell signaling responses. Here, we report a systematic approach to investigate the effect of NO2 -CLA on human coronary artery smooth muscle cells (hCASMC), based on the RNA-seq and bioinformatics analysis. There were extensive differentially expressed genes in NO2 -CLA vs...
February 23, 2018: Physiological Genomics
Mahdieh Farhangi, Farzad Kobarfard, Arash Mahboubi, Alireza Vatanara, Seyed Alireza Mortazavi
OBJECTIVE: The objective of present study was to evaluate the effect of lipid structure on physicochemical properties of chitosan-fatty acid nanomicelles and prepare an optimum ciprofloxacin loaded formulation from these conjugates which could enhance the antibacterial effects of drug against some important pathogens like P. aeroginosa. SIGNIFICANCE: Nowadays, resistance in infectious diseases is a growing worldwide concern. Nanocarriers can increase the therapeutic index and consequently reduce the antibiotic resistance...
February 16, 2018: Drug Development and Industrial Pharmacy
Obert C Chikwanha, Payam Vahmani, Voster Muchenje, Michael E R Dugan, Cletos Mapiye
Dietary fatty acids (FA) consumed by sheep, like other ruminants, can undergo biohydrogenation resulting in high proportions of saturated FA (SFA) in meat. Biohydrogenation is typically less extensive in sheep than cattle, and consequently, sheep meat can contain higher proportions of omega (n)-3 polyunsaturated FA (PUFA), and PUFA biohydrogenation intermediates (PUFA-BHI) including conjugated linoleic acid (CLA) and trans-monounsaturated FAs (t-MUFA). Sheep meat is also noted for having characteristically higher contents of branched chain FA (BCFA)...
February 2018: Food Research International
Luis Villacorta, Lucia Minarrieta, Sonia R Salvatore, Nicholas K Khoo, Oren Rom, Zhen Gao, Rebecca C Berman, Soma Jobbagy, Lihua Li, Steven R Woodcock, Y Eugene Chen, Bruce A Freeman, Ana M Ferreira, Francisco J Schopfer, Dario A Vitturi
Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated linoleic acid (NO2-CLA). Herein, NO2-CLA generation is demonstrated within the context of acute inflammatory responses both in vitro and in vivo. Macrophage activation resulted in dose- and time-dependent CLA nitration and also in the production of secondary electrophilic and non-electrophilic derivatives. Both exogenous NO2-CLA as well as that generated in situ, attenuated NF-κB-dependent gene expression, decreased pro-inflammatory cytokine production and up-regulated Nrf2-regulated proteins...
January 12, 2018: Redox Biology
Anize Delfino von Frankenberg, André F Reis, Fernando Gerchman
Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance - abnormalities of glucose metabolism typically found in subjects with obesity - are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2...
December 2017: Archives of Endocrinology and Metabolism
Peiyi Shen, Jonathan C Kershaw, Yiren Yue, Ou Wang, Kee-Hong Kim, D Julian McClements, Yeonhwa Park
Conjugated linoleic acid (CLA) has been reported to reduce fat storage in cell culture and animal models. In the current study, the effects of CLA on the fat accumulation, activities, and proteomics were investigated using Caenorhabditis elegans. 100 µM CLA-TG nanoemulsion significantly reduced fat accumulation by 29% compared to linoleic acid (LA)-TG treatment via sir-2.1 (the ortholog of Sirtuin 1), without altering the worm size, growth rate, and pumping rate of C. elegans. CLA significantly increased moving speed and amplitude (the average centroid displacement over the entire track) of wild type worms compared to the LA group and these effects were dependent on aak-2 (AMPKα ortholog) and sir-2...
May 30, 2018: Food Chemistry
Mohsen Mohammadi-Sartang, Zahra Sohrabi, Zahra Esmaeilinezhad, Seyed Mohammad Aqaeinezhad R, Yahya Jalilpiran
The results of human clinical trials examining the effects of conjugated linoleic acid (CLA) on leptin concentration are inconsistent. Our objective was to elucidate the role of conjugated linoleic acid supplementation on leptin through a systematic review and a meta-analysis of available randomized placebo-controlled trials (RCTs). We searched the PubMed, SCOPUS, and ISI web of science up to February2017, in English, to identify RCTs investigating the effect of CLA supplements on plasma leptin concentrations...
February 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Barbara D Pachikian, Céline Druart, Emilie Catry, Laure B Bindels, Audrey M Neyrinck, Yvan Larondelle, Patrice D Cani, Nathalie M Delzenne
SCOPE: Conjugated linoleic acids are linoleic acid isomers found in the diet that can also be produced through bacterial metabolism of polyunsaturated fatty acids. Our objective was to evaluate the contribution of fatty acid metabolites produced from polyunsaturated fatty acids by the gut microbiota in vivo to regulation of hepatic lipid metabolism and steatosis. METHODS AND RESULTS: In mice with depleted n-3 polyunsaturated fatty acids, we observed an accumulation of trans-11,trans-13 CLA and cis-9,cis-11 conjugated linoleic acids in the liver tissue that were associated with an increased triglyceride content and expression of lipogenic genes...
2018: PloS One
Priscila Nogueira Bezan, Héric Holland, Gabriela Salim de Castro, João Felipe Rito Cardoso, Paula Payão Ovidio, Philip C Calder, Alceu Afonso Jordao
Obesity and related diseases are becoming more prevalent. Conjugated linoleic acid (CLA) might be a useful coadjutant treatment helping to decrease fat mass. However, the precise impact of CLA is unclear because the decreased body fat mass is followed by an increase in insulin resistance. This study aimed to evaluate some of the consequences of a high dose of CLA in rats fed a normal low fat or a high fat diet for 30 days. Male Wistar rats were separated into 4 groups (each n = 10): Control group receiving 7% fat (soybean oil); CLA group receiving 4% soybean oil and 3% CLA mixture; animal fat (AF) group, receiving 45% fat (lard); and animal fat plus CLA (AF+CLA) group, receiving 42% lard and 3% CLA mixture...
January 31, 2018: Experimental and Clinical Endocrinology & Diabetes
A N Bradbery, J A Coverdale, K L Vernon, J L Leatherwood, C E Arnold, R A Dabareiner, M K Kahn, A A Millican, T H Welsh
Seventeen yearling Quarter Horses were used in a randomized complete block design for a 56-d trial to determine ability of dietary conjugated linoleic acid (CLA) to mitigate joint inflammation and alter cartilage turnover following an inflammatory insult. Horses were blocked by age, sex, and BW, and randomly assigned to dietary treatments consisting of commercial concentrate offered at 1% BW (as-fed) supplemented with either 1% soybean oil (CON; n = 6), 0.5% soybean oil and 0.5% CLA (LOW; n = 5; 55% purity; Lutalin®, BASF Corp...
January 29, 2018: Journal of Animal Science
Tyler Maher, Miriam E Clegg
Dietary fat has been implicated in the rise of obesity due to its energy density, palatability and weak effects on satiety. As fat is a major contributor to overall energy intake, incorporating fat with satiating properties could potentially reduce energy intake. This review outlines the potential mechanisms, as far as we know, by which Medium-Chain Triglycerides (MCT), Conjugated Linoleic Acid (CLA), Short-Chain Fatty Acids (SCFA), Diacylglycerol (DAG), n-3 PUFA, and Small Particle Lipids, exerts their satiating effects...
January 23, 2018: Critical Reviews in Food Science and Nutrition
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