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conjugated linolic acid

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https://www.readbyqxmd.com/read/28918508/metabolic-engineering-of-schizosaccharomyces-pombe-to-produce-punicic-acid-a-conjugated-fatty-acid-with-nutraceutic-properties
#1
Martina Garaiova, Elzbieta Mietkiewska, Randall J Weselake, Roman Holic
Punicic acid (PuA) is a conjugated linolenic acid (C18:3Δ(9c,11t,13c)) with a wide range of nutraceutic effects with the potential to reduce the incidence of a number of health disorders including diabetes, obesity, and cancer. It is the main component of seed oil from Punica granatum and Trichosanthes kirilowii. Previously, production of relatively high levels of this unusual fatty acid in the seed oil of transgenic Arabidopsis thaliana plant was accomplished by the use of A. thaliana fad3/fae1 mutant high in linoleic acid (18:2∆(9c,12c)) and by co-expression of P...
September 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28918150/short-communication-effects-of-lysolecithin-on-milk-fat-synthesis-and-milk-fatty-acid-profile-of-cows-fed-diets-differing-in-fiber-and-unsaturated-fatty-acid-concentration
#2
D E Rico, Y Ying, K J Harvatine
Thirteen multiparous Holstein cows were used in a crossover design that tested the effect of lysolecithin in diets differing in neutral detergent fiber (NDF) and unsaturated fatty acid (FA) concentrations. Experimental periods were 20 d in length and included two 10-d phases. A standard fiber and lower fat diet was fed the first 10 d (30.5% NDF, no added oil, lower-risk phase) and a lower NDF and higher oil diet was fed during the second 10 d (29.0% NDF and 2% oil from whole soybeans and soybean oil, high-risk phase)...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28891292/ruminal-biohydrogenation-kinetics-of-defatted-flaxseed-and-sunflower-is-affected-by-heat-treatment
#3
Saman Lashkari, Lone Hymøller, Soren Krogh Jensen
The effect of heat treatment on biohydrogenation of linoleic acid (LA) and linolenic acid (LNA) and formation of stearic acid (SA), cis-9, trans-11 conjugated LA (CLA), trans-10, cis-12 CLA and trans vaccenic acid (VA) was studied in in vitro incubations with diluted rumen fluid as inoculum and partly defatted flaxseed (DF) and partly defatted sunflower (DS) as test feeds. Feeds were heated in a laboratory oven at 110 °C for 0 (unheated), 45 or 90 min. Michaelis-Menten kinetics was applied for quantifying biohydrogenation rate...
September 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28889933/bacterial-conjugated-linoleic-acid-production-and-their-applications
#4
REVIEW
Bo Yang, He Gao, Catherine Stanton, R Paul Ross, Hao Zhang, Yong Q Chen, Haiqin Chen, Wei Chen
Conjugated linoleic acid (CLA) has been shown to exert various potential physiological properties including anti-carcinogenic, anti-obesity, anti-cardiovascular and anti-diabetic activities, and consequently has been considered as a promising food supplement. Bacterial biosynthesis of CLA is an attractive approach for commercial production due to its high isomer-selectivity and convenient purification process. Many bacterial species have been reported to convert free linoleic acid (LA) to CLA, hitherto only the precise CLA-producing mechanisms in Propionibacterium acnes and Lactobacillus plantarum have been illustrated completely, prompting the development of recombinant technology used in CLA production...
September 7, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28885029/polymer-nanosheets-from-supramolecular-assemblies-of-conjugated-linoleic-acid-high-surface-area-adsorbents-from-renewable-materials
#5
Xunda Feng, Kohsuke Kawabata, Dylan M Whang, Chinedum O Osuji
We present a strategy for robustly crosslinking self-assembled lamellar mesophases made from plant-derived materials to generate polymer nanosheets decorated with a high density of functional groups. We formulate a supramoleclar complex by hydrogen-bonding conjugated linoleic acid moieties to a structure-directing tribasic aromatic core. The resulting constructs self-assemble into a thermotropic lamellar mesophase. Photo-crosslinking the mesophase with the aid of an acrylate crosslinker yields a polymeric material with high-fidelity retention of the lamellar mesophase structure...
September 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28873643/influence-of-seasonal-variation-and-ultra-high-temperature-processing-on-lipid-profile-and-fat-globule-structure-of-swedish-cow-milk
#6
Jing Lu, Jana Pickova, José L Vázquez-Gutiérrez, Maud Langton
To investigate the effects of seasonal variations and processing on cow milk fat, raw milk collected in six individual months and corresponding ultra high temperature (UHT) milk were analyzed. Similar seasonal variations in lipid classes and fatty acid composition were found in raw and UHT milk. Under commercial processing, lipid content was standardized to approximately 1.5% in UHT milk. Decreased diameter of fat droplets (around 1µm) and thinner globule membranes were observed, as revealed using confocal laser scanning microscopy (CLSM)...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28843691/dietary-supplementation-with-dried-olive-pomace-in-dairy-cows-modifies-the-composition-of-fatty-acids-and-the-aromatic-profile-in-milk-and-related-cheese
#7
F Castellani, A Vitali, N Bernardi, E Marone, F Palazzo, L Grotta, G Martino
This study aimed to evaluate the effect of dietary integration of dried olive pomace (DOP), a by-product of olive oil separation, on nutritional and aromatic properties of milk and cheese. Twenty dairy cows were divided into 2 groups that were balanced for milk yield, parity, and days in milk. The control group was fed a conventional diet (20 kg of dry matter/head per day), whereas the experimental group (EG) received the conventional diet supplemented with DOP as 10% of dry matter. During the trial, milk yield was recorded and the samples of milk, cheese, total mixed rations, and DOP were collected and analyzed to determine the chemical-nutritional composition and aromatic profile...
August 23, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28843683/effect-of-substituting-soybean-meal-and-canola-cake-with-dried-distillers-grains-with-solubles-at-2-dietary-crude-protein-levels-on-feed-intake-milk-production-and-milk-quality-in-dairy-cows
#8
C Gaillard, M T Sørensen, M Vestergaard, M R Weisbjerg, A Basar, M K Larsen, H Martinussen, U Kidmose, J Sehested
Dried distillers grain with solubles (DDGS) is an alternative source of feed protein for dairy cows. Previous studies found that DDGS, based on grains other than corn, can substitute for soybean meal and canola cake as a dietary protein source without reducing milk production or quality. As societal concerns exist, and in many areas strict regulation, regarding nitrogen excretion from dairy cows, the dairy industry has focused on reducing dietary protein level and nitrogen excretion. In the present study, we investigated the use of DDGS as a protein source, at a marginally low dietary crude protein (CP) levels, in a grass-clover and corn silage-based ration...
August 23, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28833935/characterization-of-the-triple-component-linoleic-acid-isomerase-in-lactobacillus-plantarum-zs2058-by-genetic-manipulation
#9
Bo Yang, Hui Qi, Zhennan Gu, Zhang Hao, Wei Chen, Haiqin Chen, Yong Q Chen
AIM: To assess the mechanism for CLA production in Lactobacillus plantarum ZS2058. METHODS AND RESULTS: Conjugated linoleic acid (CLA) has attracted great interests for decades due to its health-associated benefits including anti-cancer, anti-atherogenic, anti-obesity, and modulation of the immune system. A number of microbial CLA producers were widely reported including lactic acid bacteria. Lb. plantarum ZS2058, an isolate from Chinese traditional fermented food, could convert LA to CLA with various intermediates...
August 18, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28822549/effect-of-substituting-soybean-meal-and-canola-cake-with-grain-based-dried-distillers-grains-with-solubles-as-a-protein-source-on-feed-intake-milk-production-and-milk-quality-in-dairy-cows
#10
C Gaillard, M T Sørensen, M Vestergaard, M R Weisbjerg, A Basar, M K Larsen, H Martinussen, U Kidmose, J Sehested
The growth of the bioethanol industry is leading to an increase in the production of coproducts such as dried distillers grains with solubles (DDGS). Both corn-based DDGS and grain-based DDGS (gDDGS; defined as originating from grain sources such as barley, wheat, triticale, or a mix, excluding corn) appear to be relevant sources of feed and protein for dairy cows. To date, most of the studies investigating DDGS have been performed with corn-based DDGS. The objectives of this study were to determine the effects of the proportion of gDDGS in the diet on feed intake, milk production, and milk quality...
August 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28815782/influence-of-conjugated-linoleic-acids-and-vitamin-e-on-milk-fatty-acid-composition-and-concentrations-of-vitamin-a-and-%C3%AE-tocopherol-in-blood-and-milk-of-dairy-cows
#11
S Schäfers, U Meyer, D von Soosten, L Hüther, C Drong, K Eder, E Most, A Tröscher, W Pelletier, A Zeyner, S Dänicke
The objective of this trial was to investigate the influences of conjugated linoleic acid (CLA) and vitamin E (Vit. E) and their interactions on fatty acid composition and vitamins in milk (α-tocopherol, retinol and β-carotene) as well as on α-tocopherol in blood of pluriparous cows from week 6 ante partum until week 10 post-partum (p.p.). We assigned 59 pluriparous German Holstein cows to four treatment groups with the treatment factors CLA and Vit. E at two levels in a 2 × 2 factorial design. Milk fatty acid composition and milk vitamins were analysed on lactation days 7 and 28...
August 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28804001/production-of-trans-and-conjugated-fatty-acids-in-dairy-ruminants-and-their-putative-effects-on-human-health-a-review
#12
REVIEW
Anne Ferlay, Laurence Bernard, Annabelle Meynadier, Corinne Malpuech-Brugère
Consumption of milk and dairy products is important in Western industrialised countries. Fat content is an important constituent contributing to the nutritional quality of milk and dairy products. In order to improve the health of consumers, there is high interest in improving their fatty acid (FA) composition, which depends principally on rumen and mammary metabolism. This paper reviews the lipid metabolism in ruminants, with a particular focus on the production of trans and conjugated linoleic acids (CLA) and conjugated linolenic acids (CLnA) in the rumen...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28795443/effect-of-conjugated-linoleic-acids-and-omega-3-fatty-acids-with-or-without-resistance-training-on-muscle-mass-in-high-fat-diet-fed-middle-aged-mice
#13
Sang-Rok Lee, Andy V Khamoui, Edward Jo, Michael C Zourdos, Lynn B Panton, Michael J Ormsbee, Jeong-Su Kim
This study investigated the effects of 20 weeks of combined conjugated linoleic acid/omega-3 fatty acid (n-3) administration independently or combined with resistance exercise training (RET) muscle in middle-aged mice consuming a high-fat diet (HFD). Nine-month-old C57BL/6 mice were randomly assigned into four experimental groups (H: high-fat diet, HE: H + RET, HCN: H + CLA/n-3, and HECN: H + CLA/n3 + RET). Body composition and functional capacity were assessed at pre- and post-intervention. Muscle tissues were collected at 14 months of age...
August 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28771065/acrolein-induced-oxidative-stress-and-genotoxicity-in-rats-protective-effects-of-whey-protein-and-conjugated-linoleic-acid
#14
Birsen Aydın, Zülal Atlı Şekeroğlu, Vedat Şekeroğlu
Acrolein (AC), a highly reactive hazardous pollutant, poses serious threats to human health. Whey protein (WP) and conjugated linoleic acid (CLA) have beneficial health implications. We investigated the protective effects of WP and CLA against AC-induced toxicity in rats. The animals were orally gavaged with CLA (200 mg/kg/day), WP (200 mg/kg/day), AC (5 mg/kg/day), CLA + AC (200 + 5 mg/kg/day), and WP + AC (200 + 5 mg/kg/day) six days per week for 30 days. The oral administration of AC significantly induced oxidative stress by increasing thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCOs) levels and decreasing glutathione (GSH) level in the spleen, thymus, and polymorphonuclear leukocytes (PMNs)...
August 3, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28763005/seasonal-variation-in-fat-quality-and-conjugated-linoleic-acid-content-of-dairy-products-from-the-tropics-evidence-of-potential-impact-on-human-health
#15
Juliana Côrtes Nunes, Monalisa Nilza Lole Ramalho da Silva, Daniel Perrone, Alexandre Guedes Torres
Seasonal variation in conjugated linoleic acid (CLA) content and atherogenicity index (AI) of retail dairy products (whole milk, butter, and prato, a soft yellow cheese) from Brazil was investigated. CLA content of dairy products ranged from 0.55 to 1.53 g CLA/100 g fatty acids and was on average 25% higher during the rainy season compared to the dry season. Dairy products from the rainy season also had lower AI levels, indicating a lower risk of causing cardiovascular disease in consumers. This seasonality led to estimated seasonal variations of milk fat quality consumed by the population of southeastern Brazil, meaning 15% and 19% variation in daily intake of CLA and AI values, respectively...
August 1, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28752804/one-pot-conjugated-linoleic-acid-production-from-castor-oil-by-rhizopus-oryzae-lipase-and-resting-cells-of-lactobacillus-plantarum
#16
Abid Ali Khaskheli, Farah Naz Talpur, Aysun Cebeci Aydin, Sana Jawaid, Muhammad Ali Surhio, Hassan Imran Afridi
Conjugated linoleic acid (CLA) has attracted as novel type of fatty acids having unusual health-promoting properties such as anticarcinogenic and antiobesitic effects. The present work employed castor oil as substrate for one-pot production of CLA using washed cells of Lactobacillus plantarum (L. plantarum) and lipases as catalysts. Among the screened lipases, the lipase Rhizopus oryzae (ROL) greatly assisted resting cells to produce CLA. Mass spectral analysis of the product showed that two major isomers of CLA were produced in the reaction mixture i...
July 28, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28752254/interaction-between-c18-fatty-acids-and-dope-peg2000-in-langmuir-monolayers-effect-of-degree-of-unsaturation
#17
Lai Ti Gew, Misni Misran
In this study, we address the effect of the cis-double bond in 1,2-dioleoyl-sn-glycero-3-phosphoethanolamide-N-[methoxy(polyethylene glycol)-2000, DOPE PEG2000 (DP), on the Langmuir monolayer of C18 fatty acids-namely, stearic acid (SA), oleic acid (L1), linoleic acid (L2), and linolenic acid (L3)-with the same head group but different degrees of saturation on their hydrocarbon chains. Negative values of Gibbs free energy of mixing (ΔG mix) were obtained throughout the investigated ranges of the unsaturated C18 fatty-acid (L1, L2 and L3) mixed systems, indicating that very strong attractions occurred between molecules in the monolayers...
July 27, 2017: Journal of Biological Physics
https://www.readbyqxmd.com/read/28751679/conjugated-linoleic-acid-supplementation-improves-maternal-high-fat-diet-induced-programming-of-metabolic-dysfunction-in-adult-male-rat-offspring
#18
Stephanie A Segovia, Mark H Vickers, Clint Gray, Xiaoyuan D Zhang, Clare M Reynolds
The developmental origins of health and disease hypothesis proposes that an adverse early life environment, including in utero exposure to a maternal obesogenic environment, can lead to an increased long-term risk of obesity and related metabolic complications in offspring. We assessed whether maternal supplementation with conjugated linoleic acid (CLA) could prevent some of these adverse effects in offspring exposed to a maternal high fat diet. Sprague-Dawley dams consumed either a: control (CD), control with CLA (CLA), high fat (HF) or high fat with CLA (HFCLA) diet 10 days prior to mating and throughout pregnancy/lactation...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740278/effects-of-deep-fat-frying-process-on-the-oil-quality-during-french-fries-preparation
#19
Ruhollah Sayyad
The performance of the sunflower oil in deep-fat frying was assessed by evaluating the efficacy of linoleic acid level and composition of tocopherol isomeric on its frying stability. The oil was used as a frying media to fry potato strips for 6 h daily for 7 days. Standard procedures for the measurement of used frying oil degradation such as fatty acid composition, acid value, anisidine value, conjugated diene value, total polar compounds and tocopherol concentration were used. At analogous composition of tocopherol isomers, the high oleic sunflower oil with smaller value of linoleic acid content indicated higher frying stability than the oil with higher linoleic acid level...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28739973/conjugated-linoleic-acid-modulates-clinical-responses-to-oral-nitrite-and-nitrate
#20
Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin
Dietary NO3(-) (nitrate) and NO2(-) (nitrite) support (·)NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3(-)and NO2(-)metabolism and the impact of dietary lipid on nitrogen oxide metabolism and cardiovascular responses, the stable isotopes Na(15)NO3 and Na(15)NO2 were orally administered in the presence or absence of conjugated linoleic acid (cLA)...
July 24, 2017: Hypertension
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