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conjugated linolic acid

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https://www.readbyqxmd.com/read/29141135/the-fatty-acid-composition-of-lamb-liver-muscle-and-adipose-tissues-in-response-to-rumen-protected-conjugated-linoleic-acid-cla-supplementation-is-tissue-dependent
#1
Stefano Schiavon, Matteo Bergamaschi, Erika Pellattiero, Alberto Simonetto, Franco Tagliapietra
The tissue-specific response to rumen-protected conjugated linoleic acid supply (rpCLA) of liver, two muscles and three adipose tissues of heavy lambs was studied. Twenty-four lambs, 8 months old, divided into 4 groups of 6, were fed at libitum on a ration supplemented without or with a mixture of rpCLA. Silica and hydrogenated soybean oil was the rpCLA coating matrix. The lambs were slaughtered at 11 months of age. Tissues were collected and analysed for their FA profiles. The dietary rpCLA supplement had no influence on carcass fatness nor on the fat content of the liver and tissues, and had little influence on the FA profiles of these tissues...
November 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29132974/topical-electrophilic-nitro-fatty-acids-potentiate-cutaneous-inflammation
#2
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo
Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation...
November 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29130749/does-maternal-synbiotic-supplementation-affect-conjugated-linoleic-acid-level-in-breast-milk-a-randomized-placebo-controlled-clinical-trial
#3
Leila Nikniaz, Reza Mahdavi, Alireza Ostadrahimi, Zeinab Nikniaz, Soghra Aliasgharzadeh
AIM: As conjugated linoleic acid (CLA)is a potential growth promotor in newborns, the present pilot study aimed at measuring the effect of synbiotic supplementation on breast milk CLA level. MATERIALS AND METHODS: Sixty lactating mothers were randomly allocated to take either synbiotic (n = 31) or placebo (n = 29) for 30 days. Maternal anthropometric indices were measured at the onset and end of the study by standard methods and body mass index was calculated...
November 13, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29122042/peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE-agonist-fails-to-overcome-trans-10-cis-12-conjugated-linoleic-acid-cla-inhibition-of-milk-fat-in-dairy-sheep
#4
E C Sandri, M Camêra, E M Sandri, K J Harvatine, D E De Oliveira
The trans-10, cis-12 conjugated linoleic acid (CLA) causes milk fat depression by downregulating expression of genes and transcription factors involved in lipogenesis and it has been proposed that peroxisome proliferator-activated receptor gamma (PPARγ) can be inhibited by trans-10, cis-12 CLA. The PPARγ is a nuclear receptor activated by natural or synthetic ligands and promotes expression of lipogenic genes and its effect on mammary lipogenesis and the interaction with trans-10, cis-12 CLA in lactating ewes was evaluated using thiazolidinedione (TZD), a chemical PPARγ agonist...
November 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29120353/fatty-acid-profiles-of-in-vitro-digested-processed-milk
#5
Michael H Tunick, Diane L Van Hekken
Digestion of milkfat releases some long-chain (18-carbon) fatty acids (FAs) that can provide health benefits to the consumer, yet because they are found in small amounts and can be difficult to identify, there is limited information on the effects that common fluid milk processing may have on the digestibility of these FAs. This study provides FA profiles for raw and combinations of homogenized and/or heat-treated (high and ultra-high temperature pasteurization) milk, before and after in vitro digestion, in order to determine the effects of processing on the digestibility of these healthy fatty acids...
November 9, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29114968/trans10-cis12-conjugated-linoleic-acid-increases-triacylglycerol-accumulation-in-goat-mammary-epithelial-cells-in%C3%A2-vitro
#6
Tianying Zhang, Yue Ma, Hui Wang, Juan J Loor, Huifen Xu, Huaiping Shi, Jun Luo
Trans10, cis12 conjugated linoleic acid (t10c12-CLA) is well-established in decreasing milk fat content and causing milk fat depression (MFD) in dairy cattle and goats. However, the detailed mechanisms of its effect are not completely understood. Therefore, we used goat mammary epithelial cells (GMECs) to further study the molecular mechanisms whereby t10c12-CLA regulates milk fat synthesis. The optimal concentration of t10c12-CLA (100 μmol/L) for cell culture was determined through a cell vitality and morphology assay, and evaluation of abundance of apoptosis-related proteins...
November 8, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29113457/the-occurrence-of-deep-pectoral-myopathy-in-broilers-and-associated-changes-in-breast-meat-quality
#7
S Yalcin, S Ozkan, M C Acar, O Meral
1. Two experiments were conducted to determine the effect of slaughter weight on the incidence and intensity of deep pectoral myopathy (DPM) of M. pectoralis minor (p. minor muscle) in commercial conditions in Turkey and to evaluate the impact of DPM on meat quality traits of pectoralis major (p. major) muscle in broilers. 2. In Experiment 1, a total of 116 250 carcasses from 59 Ross-308 broiler flocks, classified according to slaughter weight as 2.0-2.2, 2.2-2.4, 2.4-2.6 and >2.6 kg, were evaluated for occurrence of DPM...
November 8, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29089844/cheese-as-functional-food-the-example-of-parmigiano-reggiano-and-grana-padano
#8
REVIEW
Andrea Summer, Paolo Formaggioni, Piero Franceschi, Federica Di Frangia, Federico Righi, Massimo Malacarne
Italian hard cooked types of cheese, like Parmigiano Reggiano and Grana Padano, are characterised by positive nutritional qualities. In fact, they contain substances that have particular biological activities, and therefore they can be fully considered, according to the definition given by the European Unit, as 'functional' foods. This short review concisely describes these components and the beneficial effects related to their activities. The description of the biologically active components has been organised in the following paragraphs: protein and peptides, fat and lipids, carbohydrates and prebiotics, probiotic bacteria, vitamins, mineral salts, and components of dairy products active in disease prevention...
September 2017: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/29065261/identification-of-lipid-biomarkers-to-discriminate-between-the-different-production-systems-for-asiago-pdo-cheese
#9
Severino Segato, Gianni Galaverna, Barbara Contiero, Paolo Berzaghi, Augusta Caligiani, Angela Marseglia, Giulio Cozzi
The lipid fraction of Asiago Protected Designation of Origin (PDO) cheese was analyzed to identify specific biomarkers of its main production systems through a canonical discriminant analysis. The three main production systems of the cheese were considered. Two were located in the upland (UL): pasture-based (P-UL) vs hay-based total mixed rations (H-UL). The third was located in the lowland (LL) and processed milk from cows fed maize silage-based rations (maize silage lowland: MS-LL). The discriminant analysis selected nine fatty acids and vitamin A as lipid biomarkers useful to separate the three production systems...
November 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29036761/effects-of-conjugated-linoleic-acid-n-3-and-resistance-training-on-muscle-quality-and-expression-of-atrophy-related-ubiquitin-ligases-in-middle-aged-mice-with-high-fat-dietinduced-obesity
#10
Seung-Lyul Oh, Sang-Rok Lee, Jeong-Su Kim
PURPOSE: To investigate the effects of conjugated linoleic acid (CLA)/n-3 supplements and resistance exercise training (RT) for 20 weeks on muscle quality and genes related to protein synthesis/degradation in middle-aged mice with high-fat diet (HFD)-induced obesity. METHODS: Nine-month-old C57BL/6 male mice were randomly assigned to five groups: 1) normal diet (C), 2) high-fat diet (H), 3) H+RT (HRT), 4) H+CLA/n-3 (H-CN), and 5) H+RT+CLA/n-3 (H-RTCN). HFD groups were given a diet containing 60% fat for 20 weeks, and exercised groups underwent progressive RT using weighted ladder climbing...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29031386/impact-of-conjugated-linoleic-acid-administered-to-rats-prior-and-after-carcinogenic-agent-on-arachidonic-and-linoleic-acid-metabolites-in-serum-and-tumors
#11
Małgorzata Jelińska, Agnieszka Białek, Iwona Gielecińska, Hanna Mojska, Andrzej Tokarz
The objective of the study was to assess the influence of conjugated linoleic acid (CLA) daily supplementation prior and after carcinogenic agent on the concentrations of eicosanoids - metabolites of arachidonic acid (15-, 12- or 5-hydroxyeicosatetraenoic acids (15-, 12-, 5-HETE), prostaglandin E2 (PGE2)) and linoleic acid (13- or 9-hydroxyoctadecadienoic acids (13-, 9-HODE)) in rat serum and 7,12-dimethylbenz[a]anthracene (DMBA)-induced tumors. Female rats were randomised into six groups, receiving 1% or 2% Bio-C...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29027986/effects-of-conjugated-linoleic-acid-supplementation-on-the-expression-profile-of-mirnas-in-porcine-adipose-tissue
#12
Qi Wang, Renli Qi, Hong Liu, Jing Wang, Wenming Huang, Feiyun Yang, Jinxiu Huang
Conjugated linoleic acids (CLAs) play a major role in adipocyte differentiation and lipid metabolism in animals. MicroRNAs (miRNAs) appear to be involved in many biological processes in adipose tissue. However, the specific influence on miRNAs by CLA supplementation in porcine adipose tissue remains unclear. Thus, we continuously added 1.5% CLA to the pig diet from the embryo stage to the finishing period and conducted a high-throughput sequencing approach to analyse the changes in adipose tissue miRNAs. We identified 283 known porcine miRNAs, and 14 miRNAs were differentially expressed in response to CLA treatment...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29026007/milk-fat-components-with-potential-anticancer-activity-a-review
#13
Luis M Rodríguez-Alcalá, M Pilar Castro-Gómez, Lígia L Pimentel, Javier Fontecha
During many years, the milk fat has been unfairly undervalued due to its association with higher levels of cardiovascular diseases, dyslipidaemia or obesity, among others. However, currently, this relationship is being re-evaluated because some of the dairy lipid components have been attributed potential health benefits. Due to this, and based on the increasing incidence of cancer in our society, this review work aims to discuss the state of the art concerning scientific evidences of milk lipid components and reported anticancer properties...
October 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29019657/trans-10-cis-12-conjugated-linoleic-acid-affects-expression-of-lipogenic-genes-in-mammary-glands-of-lactating-dairy-goats
#14
Huaiping Shi, Tianying Zhang, Cong Li, Jianjue Wang, Jiangtao Huang, Zhongyang Li
The molecular mechanisms on milk fat depression (MFD) in response to trans-10,cis-12-conjugated linoleic acid (t10,c12-CLA) supplementation in ruminants were elucidated in this research with dairy goats. A total of 30 2-year-old Xinong Saanen dairy goats [40 ± 5 days in milk (DIM)] at peak lactation stage were assigned to a 3 × 3 Latin square design (14 day treatment period, followed with 14 day washout). Three CLA treatments included (a) control, fed the basal diet only without CLA supplementation; (b) orally supplemented with 8 g/day of lipid-encapsulated CLA (low dose, CLA-1); and (c) orally supplemented with 16 g/day of lipid-encapsulated CLA (high dose, CLA-2)...
October 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28992034/the-effect-of-energy-restriction-on-fatty-acid-profiles-of-longissimus-dorsi-and-tissue-adipose-depots-in-sheep
#15
S Z Song, J P Wu, S G Zhao, D P Casper, B He, T Liu, X Lang, X Y Gong, L S Liu
Sheep production systems in northwest China depend mostly on natural grasslands. Seasonal growth and maturity fluctuations can cause periodical restrictions in food quality and quantity. These fluctuations, in turn, result in variability in fat deposition and fatty acid profiles in different fat depots. Consequently, the study objective was to compare fat deposition, intramuscular fat (IMF) percentage and fatty acid profiles of the longissimus dorsi (LD), kidney fat (KF), tail fat (TF), and subcutaneous fat (SF) in lambs under ME restrictions similar to seasonal changes observed in the natural grasslands of northwest China...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28990226/milk-fatty-acid-profile-from-cows-fed-with-mixed-rations-and-different-access-time-to-pastureland-during-early-lactation
#16
J Barca, M Carriquiry, L Olazabal, M Fajardo, P Chilibroste, A Meikle
Milk fatty acid (FA) profiles were determined in Holstein cows (n = 27) fed total mixed rations (TMR) ad libitum (G0) or diet composed by TMR (50% dry matter [DM] offered) plus grazing of pasture with 6 hr of access time to paddock in one session (G1) or 9 hr in two sessions (G2) at 45 days in milk (DIM). Moreover, milk FA was determined at 65 DIM when G0 cows turned out to G1 diet without adaptation period (Post-G0), G1 remained as controls. Milk FA was quantified using gas chromatography and mass spectrometry...
October 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28987717/protective-effect-of-rumenic-acid-rich-cow-s-milk-against-colitis-is-associated-with-the-activation-of-nrf2-pathway-in-a-murine-model
#17
P Bergamo, E Cocca, A Monaco, V Cozzolino, F Boscaino, I Ferrandino, F Maurano, M Rossi
Dietary supplementation with pure cis9, trans11 isomer of Conjugated Linoleic Acid -known as Rumenic Acid (RA)- improves cytoprotective defenses downstream through the activation of nuclear factor-E2-related factor-2(Nrf2). This capability, when Rumenic Acid is consumed in the form of foods, is still unknown. The ability of standard (St) or cow milk naturally-enriched in RA (En) to activate Nrf2 pathway and its impact on dextran sodium sulfate (DSS)-induced colitis was comparatively evaluated. Activity of Nrf2 pathway was investigated in colonic tissue of BALB/c mice, receiving 4-week supplement with skimmed milk (SK), St or St reinforced with pure RA (RSt) providing increasing RA dose (0, 124 or 404mg RA/kg(-1) b...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28983975/hyperglycaemia-in-transition-dairy-cows-effects-of-lactational-stage-and-conjugated-linoleic-acid-supplementation-on-glucose-metabolism-and-turnover
#18
L Grossen-Rösti, E C Kessler, A Tröscher, R M Bruckmaier, J J Gross
Supplementing conjugated linoleic acid (CLA) is supposed to spare glucose due to the milk fat-depressing effect of the trans-10, cis-12 CLA isomer, and allows repartitioning nutrients despite an energy deficiency in early lactation. However, there is still a lack of knowledge in terms of the dynamic pattern of the glucose turnover in transition dairy cows. We hypothesized that dairy cows supplemented with CLA have an altered rate of glucose turnover and insulin sensitivity during early lactation. We conducted three consecutive hyperglycaemic clamps (HGC) in weeks -2, +2 and +4 relative to parturition in Holstein cows supplemented daily either with 70 g of lipid-encapsulated CLA (6...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28976228/effect-of-palmitic-acid-on-the-mitigation-of-milk-fat-depression-syndrome-caused-by-trans-10-cis-12-conjugated-linoleic-acid-in-grazing-dairy-cows
#19
Lorenzo Danilo Granados-Rivera, Omar Hernández-Mendo, Sergio Segundo González-Muñoz, Juan Andrés Burgueño-Ferreira, German David Mendoza-Martínez, Carlos Manuel Arriaga-Jordán
The objective of the study was to evaluate the effect of adding protected palmitic acid (PA) to the ration of grazing dairy cows supplemented with protected conjugated linoleic acid (CLA) on milk production, chemical composition and fat profile. Six cows were used, 3/4 American Swiss × Zebu, under a rotational grazing system in a mixed sward with Cynodon plectostachyus, Brachiaria decumbens and Brachiaria brizantha. Furthermore, each cow received daily 4 kg concentrates and 8 kg sorghum silage, which made up the basal diet...
October 4, 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28971129/quantitative-determination-of-conjugated-linoleic-acid-and-polyunsaturated-fatty-acids-in-milk-with-c17-0-as-internal-marker-evaluation-of-different-methylation-procedures
#20
S Lashkari, S K Jensen
Fatty acids are commonly analysed by gas chromatography as their corresponding fatty acid (FA) methyl esters (FAME). For quantitative determination of individual FA an internal standard like C17:0 is necessary. Conjugated FA and polyunsaturated fatty acid (PUFA) represents a challenge in the methylation steps, as they are sensitive to pH changes and oxidation. The present study was carried out to determine the efficiency of different methylation procedures on quantitative determination of conjugated linoleic acid (CLA), PUFA and response of internal standard...
December 2017: Data in Brief
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