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conjugated linolic acid

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https://www.readbyqxmd.com/read/29792205/distinct-correlations-between-lipogenic-gene-expression-and-fatty-acid-composition-of-subcutaneous-fat-among-cattle-breeds
#1
David Gamarra, Noelia Aldai, Aisaku Arakawa, Luis Javier R Barron, Andrés López-Oceja, Marian M de Pancorbo, Masaaki Taniguchi
BACKGROUND: The fatty acid (FA) composition of adipose tissue influences the nutritional quality of meat products. The unsaturation level of FAs is determined by fatty acid desaturases such as stearoyl-CoA desaturases (SCDs), which are under control of the transcription factor sterol regulatory element-binding protein (SREBP). Differences in SCD genotype may thus confer variations in lipid metabolism and FA content among cattle breeds. This study investigated correlations between FA composition and lipogenic gene expression levels in the subcutaneous adipose tissue of beef cattle breeds of different gender from the Basque region of northern Spain...
May 23, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29778483/effect-of-replacing-maize-silage-with-red-clover-silage-in-the-diet-on-milk-fatty-acid-composition-in-cows
#2
Franziska Schulz, Edwin Westreicher-Kristen, Joachim Molkentin, Karin Knappstein, Andreas Susenbeth
This study aimed to evaluate the effect of replacing maize silage plus soybean meal with red clover silage (RCS) plus wheat on the fatty acid (FA) profile in the milk fat of cows. Forty-four lactating German Holstein cows were used in a 4 × 4 Latin square design with 21-d periods composed of 13 d of adaptation to diets followed by an 8-d sampling phase. Experimental diets offered as total mixed ration consisted of a constant forage-to-concentrate ratio (75:25) with target proportions of RCS to maize silage of 15:60 (RCS15 ), 30:45 (RCS30 ), 45:30 (RCS45 ), and 60:15 (RCS60 ) on a dry matter basis...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29772023/prepartum-supplementation-of-conjugated-linoleic-acids-cla-increased-milk-energy-output-and-decreased-serum-fatty-acids-and-%C3%AE-hydroxybutyrate-in-early-lactation-dairy-cows
#3
Rafael Caputo Oliveira, Ryan S Pralle, Lucas C de Resende, Carlos Henrique P C Nova, Valentina Caprarulo, Joshua A Jendza, Arnulf Troescher, Heather M White
Prepartum supplementation with conjugated linoleic acid (CLA) may influence lipolysis and hyperketonemia in dairy cows. The objective of this study was to examine the effect of prepartum CLA supplementation on lactation performance and serum fatty acids (FA) and β-hydroxybutyrate (BHB) in early lactation dairy cows, and secondarily on reproductive performance. Multiparous cows were enrolled in the study at 18 days prior to expected calving date, and randomly assigned 100 g/day of Lutrell Pure (BASF, Ludwigshafen, Germany; 75% FA), providing 10 g/day of each CLA isomer (trans-10 cis-12 and cis-9 trans-11 CLA) or equivalent amount of rumen inert fatty acids as control (78 g/day of Energy Booster 100; Milk Specialties Global, Eden Prairie, MN)...
2018: PloS One
https://www.readbyqxmd.com/read/29771123/carotenoids-experimental-ionization-energies-and-capacity-at-inhibiting-lipid-peroxidation-in-a-chemical-model-of-dietary-oxidative-stress
#4
Olivier Dangles, Pascale Goupy, Michel Carail, Alexandre Giuliani, Denis Duflot, Catherine Caris-Veyrat
Carotenoids are important natural pigments and micronutrients contributing to health prevention by several mechanisms, including their electron-donating (antioxidant) activity. In this work, a large series of carotenoids, including 11 carotenes and 14 xanthophylls, has been investigated by wavelength-resolved atmospheric pressure photoionization mass spectrometry (DISCO line of SOLEIL synchrotron), thus allowing the experimental determination of their ionization energy (IE) for the first time. On the other hand, the carotenoids have been also investigated for their ability to inhibit the heme iron-induced peroxidation of linoleic acid in mildly acidic micelles, a simple but relevant chemical model of oxidative stress in the gastric compartment...
May 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29765212/the-effect-of-conjugated-linoleic-acid-on-oxidative-stress-and-matrix-metalloproteinases-2-and-9-in-patients-with-copd
#5
Somaieh Matin, Ali Nemati, Hassan Ghobadi, Reza Alipanah-Moghadam, Lotfollah Rezagholizadeh
Background: Natural antioxidants in foods may be used in prevention and treatment of oxidative stress and inflammation in COPD. Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients. Materials and methods: This clinical trial study was conducted on 90 (supplement group=45 and control group=45) COPD patients in Ardabil city, Iran, in 2015...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29763687/therapeutic-efficacy-of-lipid-emulsions-of-docetaxel-linoleic-acid-conjugate-in-breast-cancer
#6
Tao Zhang, Meng Li, Ruyi Yang, Dong Zhang, Jibin Guan, Jiang Yu, Bin Yang, Huicong Zhang, Shenwu Zhang, Dan Liu, Yongjun Wang
Docetaxel (DTX) solution is among the most widely-used parenteral formulations used in advanced breast cancer therapy. However, severe side effects have been observed due to the use of ethanol and polysorbate 80. Herein, a novel DTX-based prodrug, docetaxel-linoleic acid conjugate (DTX-LA) was successfully synthesized. The high lipid solubility of DTX and DTX-LA resulted in a tendency for them to become entrapped in the oil core of the emulsions. As anticipated, nano-sized, sterically stabilized oil-in-water lipid emulsions (LMs) of DTX-LA LMs and DTX LMs were successfully constructed...
May 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29758402/lactation-related-changes-in-tissue-expression-of-pedf-in-dairy-cows
#7
H Sadri, B Saremi, S Dänicke, J Rehage, M Mielenz, A Hosseini, H Sauerwein
Pigment epithelium-derived factor (PEDF) is evolving as metabolic regulatory protein. Albeit mostly considered in only pathological conditions related to excess energy intake resulting in obesity and insulin resistance, PEDF is likely to be involved in other physiological processes such as the homeorhetic adaptation of metabolism to lactation. We aimed to characterize the expression of PEDF and its association to the concomitant mobilization of body reserves during lactation in nonobese subjects. This mobilization is particularly distinct in dairy cows, and we therefore assessed the mRNA expression of PEDF and its putative receptors in different tissues in 2 trials with dairy cows fed with or without conjugated linoleic acids (CLAs)...
April 17, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29753473/dietary-linseed-supplementation-affects-the-fatty-acid-composition-of-the-sn-2-position-of-triglycerides-in-sheep-milk
#8
A Serra, G Conte, F Ciucci, E Bulleri, L Corrales-Retana, A Cappucci, A Buccioni, M Mele
In the human intestine, lipids are absorbed as sn-2 monoglycerides (sn-2, also named β-position), produced mainly by pancreatic lipases, which hydrolysate the triglyceride molecule in positions 1 and 3 (sn-1,3, α-position). The fatty acids esterified in sn-2 are thus preferentially absorbed, which means that the bioavailability of a single fatty acid is affected by its position on the triglyceride. This experiment is carried out with the milk used to make cheese applied in a study with 42 human volunteers...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29750886/co-administration-of-conjugated-linoleic-acid-and-rosiglitazone-increases-atherogenic-co-efficicient-and-alters-isoprenaline-induced-vasodilatation-in-rats-fed-high-fat-diet
#9
B K Chai, Y S Lau, B J Loong, M M Rais, K N Ting, D M Dharmani, M S Kumar
The cis(c)-9, trans(t)-11 (c9,t11) and t10,c12 isomers of conjugated linoleic acid (CLA) have been reported as agonists of peroxisome proliferator-activated receptor (PPAR) and beneficial in lipidemia and glycaemia. However, it is unclear whether CLA isomers enhance or antagonize effects of conventional drugs targeting PPAR. Male Sprague-Dawley rats were fed high fat diet (HFD) for 8 weeks and treated without or with CLA, rosiglitazone or both for 4 weeks. Oral glucose tolerance and surrogate markers of insulin resistance were not significantly different for all treatments compared to untreated normal diet (ND) or HFD group, except lipoprotein levels...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29750812/studying-heating-effects-on-desi-ghee-obtained-from-buffalo-milk-using-fluorescence-spectroscopy
#10
Naveed Ahmad, M Saleem
Characterisation and thermal deterioration of desi ghee obtained from buffalo milk is presented for the first time using the potential of Fluorescence spectroscopy. The emission bands in non-heated desi ghee centred at 375 nm is labelled for vitamin D, 390 nm for vitamin K, 440-460 nm for isomers of conjugated linoleic acid (CLA), 490 nm for vitamin A and the region 620-700 nm is assigned to chlorophyll contents. Fluorescence emission spectra from all the heated and non-heated ghee samples were recorded using excitation wavelengths at 280, and 410 nm which were found best for getting maximum spectral signatures...
2018: PloS One
https://www.readbyqxmd.com/read/29739585/comparison-of-methylation-methods-for-fatty-acid-analysis-of-milk-fat
#11
Zhiqian Liu, Vilnis Ezernieks, Simone Rochfort, Ben Cocks
Three acid- and alkaline-catalysed transesterification methods were compared with the aim to validate a simple yet reliable protocol for fatty acid (FA) profiling of milk fat. While both the acid- and alkaline-catalysed methods were able to convert completely triglycerides and phospholipids into fatty acid methyl esters (FAMEs), the acid catalyst caused significant degradation of conjugated linoleic acid C18:2c9t11 at high temperature. Although a milder temperature can mitigate this negative impact, a long reaction time (2 h) is required to achieve full methylation...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29735047/brazilian-cheeses-a-survey-covering-physicochemical-characteristics-mineral-content-fatty-acid-profile-and-volatile-compounds
#12
Juliana Matera, Aderval S Luna, Diego B Batista, Tatiana C Pimentel, Jeremias Moraes, Bruna A Kamimura, Marcus Vinicius S Ferreira, Hugo L A Silva, Simone P Mathias, Erick A Esmerino, Monica Q Freitas, Renata S L Raices, Simone L Quitério, Anderson S Sant'Ana, Marcia C Silva, Adriano G Cruz
Chemical characteristics, mineral levels (Ca, Fe, K, Mg, Na, Zn, Cr, Cu, and Mn), fatty acid profile and volatile compounds of typically Brazilian cheeses (Minas Frescal, Minas Padrão, Prato and Coalho, n = 200, equally distributed) were investigated. The cheeses have proven to be a source of Ca, Cu and Zn (>15% RDI/30 g), with low atherogenic and thrombogenic indices, with ethanol as the main alcohol and butanoic acid as the main acid, and moderate to high sodium content. Minas Frescal cheese presented lower nutritional value (proteins, lipids, and minerals), while Prato cheese had a higher fatty acids concentration, including conjugated linoleic acid (0...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29732100/new-activation-mechanism-for-half-sandwich-organometallic-anticancer-complexes
#13
Samya Banerjee, Joan J Soldevila-Barreda, Juliusz A Wolny, Christopher A Wootton, Abraha Habtemariam, Isolda Romero-Canelón, Feng Chen, Guy J Clarkson, Ivan Prokes, Lijiang Song, Peter B O'Connor, Volker Schünemann, Peter J Sadler
The Cp x C-H protons in certain organometallic RhIII half-sandwich anticancer complexes [(η5 -Cp x )Rh( N , N ')Cl]+ , where Cp x = Cp*, phenyl or biphenyl-Me4 Cp, and N , N ' = bipyridine, dimethylbipyridine, or phenanthroline, can undergo rapid sequential deuteration of all 15 Cp* methyl protons in aqueous media at ambient temperature. DFT calculations suggest a mechanism involving abstraction of a Cp* proton by the Rh-hydroxido complex, followed by sequential H/D exchange, with the Cp* rings behaving like dynamic molecular 'twisters'...
March 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29715109/fatty-acids-of-cla-enriched-egg-yolks-can-induce-mitochondrial-pathway-of-apoptosis-in-mcf-7-breast-cancer-cells
#14
Aneta A Koronowicz, Mariola Drozdowska, Paula Banks, Ewelina Piasna-Słupecka, Dominik Domagała, Teresa Leszczyńska
BACKGROUND: Fatty acids from conjugated linoleic acid (CLA)-enriched egg yolk suppressed the viability of the MCF-7 cancer line more effectively than non-enriched egg yolk. Herein we aimed to determine the molecular mechanisms by analysing the expression and activation of proteins involved in cellular stress and apoptosis signaling. MATERIALS AND METHODS: Forty-eight Isa Brown laying hens (26-week-old) were fed a fortified (0.75% CLA) or a control diet (0% CLA) for 4 months...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29702469/neutral-and-acid-adapted-fatty-acid-vesicles-of-conjugated-linoleic-acid
#15
Ye Fan, Jie Ma, Yun Fang, Tingting Liu, Xueyi Hu, Yongmei Xia
FAVs (fatty acid vesicles), originated from natural biomass and created available biointerface, have advantages of biocompatibility, low-cost, and easy self-assembly in aqueous solution due to their dynamic feature. However, there is no example of applying FAVs in contact with human body since they are inherently alkaline-adapted and pH windows for the FAV formation and application are very narrow and far away from the physiological pH range. In this work an attempt to turn the alkaline-adapted FAVs into neutral and acid-adapted ones was made by fabricating the amphiphile-hybrid vesicles of CLA (conjugated linoleic acid) with a typical cosmetic emulsifier SDS (sodium dodecylsulfate) and/or a co-emulsifier DA (dodecyl alcohol)...
April 20, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29697270/antitumor-properties-of-cla-enriched-food-products
#16
Aneta A Koronowicz, Paula Banks
In this manuscript, we reviewed the available literature on the effects of conjugated linoleic acid (CLA)-enriched food products, including meat, dairy products, and eggs on cancer, both in vivo and in vitro. Based on our own studies on CLA-enriched eggs, we also identified potential molecular mechanisms by which such products may act on cancer cells. We propose the mitochondrial apoptosis pathway as mainly accountable for the reduction of cancer cells viability. Our hypothesis is supported by observed changes in expression of genes associated with downregulation of AKT/mTOR signalling pathway...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29682807/the-effect-of-pomegranate-seed-oil-and-grapeseed-oil-on-cis-9-trans-11-cla-rumenic-acid-n-3-and-n-6-fatty-acids-deposition-in-selected-tissues-of-chickens
#17
A Białek, M Białek, T Lepionka, K Kaszperuk, T Banaszkiewicz, A Tokarz
The aim of this study was to determine whether diet modification with different doses of grapeseed oil or pomegranate seed oil will improve the nutritive value of poultry meat in terms of n-3 and n-6 fatty acids, as well as rumenic acid (cis-9, trans-11 conjugated linoleic acid) content in tissues diversified in lipid composition and roles in lipid metabolism. To evaluate the influence of applied diet modification comprehensively, two chemometric methods were used. Results of cluster analysis demonstrated that pomegranate seed oil modifies fatty acids profile in the most potent way, mainly by an increase in rumenic acid content...
April 23, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29680648/effects-of-carbohydrate-type-or-bicarbonate-addition-to-grass-silage-based-diets-on-enteric-methane-emissions-and-milk-fatty-acid-composition-in-dairy-cows
#18
A Bougouin, A Ferlay, M Doreau, C Martin
The aim of the study was to compare the effect of fiber- or starch-rich diets based on grass silage, supplemented or not with bicarbonate, on CH4 emissions and milk fatty acid (FA) profile in dairy cows. The experiment was conducted as a 4 × 4 Latin square design with a 2 × 2 factorial arrangement: carbohydrate type [starch- or fiber-rich diets with dietary starch level of 23.1 and 5.9% on a dry matter basis, respectively], without or with bicarbonate addition [0 and 1% of the dry matter intake, respectively]...
April 18, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29672133/meat-eggs-full-fat-dairy-and-nutritional-boogeymen-does-the-way-in-which-animals-are-raised-affect-health-differently-in-humans
#19
Christopher P Haskins, George Henderson, Colin E Champ
BACKGROUND:  Food recommendations to improve cancer prevention are generally based on epidemiologic data and remain inconsistent. These epidemiologic studies, while controversial, have generally produced results that caution against the consumption of high-fat foods, including eggs, red meat, and full-fat dairy, such as butter and cheese. Yet, limited data exist assessing the quality of individual sources of these foods and the effect each has after its consumption. This study set out to assess the impact sources of food within the same groups from animals raised differently on variables associated with health in human studies...
April 19, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29672124/the-effects-of-supplementation-with-conjugated-linoleic-acid-on-anthropometric-indices-and-body-composition-in-overweight-and-obese-subjects-a-systematic-review-and-meta-analysis
#20
Nazli Namazi, Pardis Irandoost, Bagher Larijani, Leila Azadbakht
Clinical trials have indicated conflicting results on the effects of conjugated linoleic acid (CLA) on obesity. The present study aimed to systematically review controlled clinical trials examining the effects of CLA on anthropometric indices and body composition in overweight and obese subjects. Pubmed, Scopus, Web of science, and Cochrane databases were searched between 2000 and December 2017 with no language restriction. Placebo-controlled clinical trials that reported anthropometric indices and body composition in overweight and obese subjects were included...
April 19, 2018: Critical Reviews in Food Science and Nutrition
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