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conjugated linolic acid

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https://www.readbyqxmd.com/read/29324748/trans10-cis12-conjugated-linoleic-acid-inhibits-proliferation-and-migration-of-ovarian-cancer-cells-by-inducing-er-stress-autophagy-and-modulation-of-src
#1
Mian M K Shahzad, Mildred Felder, Kai Ludwig, Hannah R Van Galder, Matthew L Anderson, Jong Kim, Mark E Cook, Arvinder K Kapur, Manish S Patankar
The goal of this study was to investigate the anti-cancer effects of Trans10,cis12 conjugated linoleic acid (t10,c12 CLA). MTT assays and QCM™ chemotaxis 96-wells were used to test the effect of t10,c12 CLA on the proliferation and migration and invasion of cancer cells. qPCR and Western Blotting were used to determine the expression of specific factors. RNA sequencing was conducted using the Illumina platform and apoptosis was measured using a flow cytometry assay. t10,c12 CLA (IC50, 7 μM) inhibited proliferation of ovarian cancer cell lines SKOV-3 and A2780...
2018: PloS One
https://www.readbyqxmd.com/read/29318897/in-vitro-and-in-silico-characterisation-of-lactobacillus-paraplantarum-d2-1-a-starter-culture-for-soymilk-fermentation
#2
Akihito Endo, Fuko Sasaki, Shintaro Maeno, Yu Kanesaki, Yu Hamaguchi, Glaezel Angelique Torres, Satoru Tomita, Junichi Nakagawa
Soymilk contains several functional nutrients and is thus a promising ingredient for production of functional foods. The present research aimed to study starter properties, functional characteristics and safety of Lactobacillus paraplantarum D2-1, a promising starter culture for soymilk fermentation. Strain D2-1 actively fermented soymilk within 24 h but had weak activity of additional acid production after 7 d. Succinate and acetoin, which could be linked to flavour and taste, were accumulated in fermented soymilk...
January 10, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29310736/anti-inflammatory-effects-of-conjugated-linoleic-acid-isomers-and-essential-fatty-acids-in-bovine-mammary-epithelial-cells
#3
D Dipasquale, L Basiricò, P Morera, R Primi, A Tröscher, U Bernabucci
Fatty acids are important modulators of inflammatory responses, in particular, n-3 and n-6 essential fatty acids and CLA have received particular attention for their ability to modulate inflammation. The objectives of this study were to compare the effects of CLA and essential fatty acids on the expression of pro and anti- inflammatory cytokines and their protective efficacy against inflammatory status in mammary gland by an in vitro model based on bovine mammary epithelial cells (BME-UV1). Bovine mammary epithelial cells were treated with complete medium containing either 50 µM of cis-9, trans-11 CLA (c9,t11 CLA) or trans-10, cis-12 CLA (t10,c12 CLA) or (α)-linolenic acid (aLnA) or (γ)-linolenic acid (gLnA) or linoleic acid (LA)...
January 9, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29306896/serum-conjugated-linoleic-acid-and-risk-of-incident-heart-failure-in-older-men-the-british-regional-heart-study
#4
S Goya Wannamethee, Barbara J Jefferis, Lucy Lennon, Olia Papacosta, Peter H Whincup, Aroon D Hingorani
BACKGROUND: Evidence largely from animal studies suggests that conjugated linoleic acid (CLA) may have cardiovascular health benefits. However, few prospective studies have examined the association between CLA and cardiovascular disease. We have prospectively examined the association between serum CLA and incident coronary heart disease and heart failure (HF) in older men. METHODS AND RESULTS: Prospective study of 3806 men, aged 60 to 79 years, without prevalent HF followed up for an average of 13 years, during which there were 295 incident HF cases...
January 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29306345/evaluation-of-the-effects-of-different-diets-on-microbiome-diversity-and-fatty-acid-composition-of-rumen-liquor-in-dairy-goat
#5
P Cremonesi, G Conte, M Severgnini, F Turri, A Monni, E Capra, L Rapetti, S Colombini, S Chessa, G Battelli, S P Alves, M Mele, B Castiglioni
Fat supplementation plays an important role in defining milk fatty acids (FA) composition of ruminant products. The use of sources rich in linoleic and α-linolenic acid favors the accumulation of conjugated linoleic acids isomers, increasing the healthy properties of milk. Ruminal microbiota plays a pivotal role in defining milk FA composition, and its profile is affected by diet composition. The aim of this study was to investigate the responses of rumen FA production and microbial structure to hemp or linseed supplementation in diets of dairy goats...
January 8, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29304106/bovine-dairy-complex-lipids-improve-in-vitro-measures-of-small-intestinal-epithelial-barrier-integrity
#6
Rachel C Anderson, Alastair K H MacGibbon, Neill Haggarty, Kelly M Armstrong, Nicole C Roy
Appropriate intestinal barrier maturation is essential for absorbing nutrients and preventing pathogens and toxins from entering the body. Compared to breast-fed infants, formula-fed infants are more susceptible to barrier dysfunction-associated illnesses. In infant formula dairy lipids are usually replaced with plant lipids. We hypothesised that dairy complex lipids improve in vitro intestinal epithelial barrier integrity. We tested milkfat high in conjugated linoleic acid, beta serum (SureStart™Lipid100), beta serum concentrate (BSC) and a ganglioside-rich fraction (G600)...
2018: PloS One
https://www.readbyqxmd.com/read/29290444/milk-from-cows-fed-a-diet-with-a-high-forage-concentrate-ratio-improves-inflammatory-state-oxidative-stress-and-mitochondrial-function-in-rats
#7
Gina Cavaliere, Giovanna Trinchese, Nadia Musco, Federico Infascelli, Chiara De Filippo, Vincenzo Mastellone, Valeria Maria Morittu, Pietro Lombardi, Raffaella Tudisco, Micaela Grossi, Vincenzo Monda, Monica I Cutrignelli, Antonietta Messina, Serena Calabrò, Heleena B Moni, Luigi Stradella, Giovanni Messina, Marcellino Monda, Marianna Crispino, Maria Pina Mollica
Excessive energy intake may evoke complex biochemical processes characterized by inflammation, oxidative stress, and impairment of mitochondrial function that represent the main factors underlying noncommunicable diseases. Because cow milk is widely used for human nutrition and in food industry processing, the nutritional quality of milk is of special interest with respect to human health. In our study, we analyzed milk produced by dairy cows fed a diet characterized by a high forage:concentrate ratio (high forage milk, HFM)...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29288248/effect-of-conjugated-linoleic-acid-on-blood-inflammatory-markers-a-systematic-review-and-meta-analysis-on-randomized-controlled-trials
#8
REVIEW
Fahimeh Haghighatdoost, B Fatemeh Nobakht M Gh
BACKGROUND/OBJECTIVES: Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid with attractive biological activities. Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models. However, the effects of CLA treatment on the inflammatory markers in humans are controversial. Therefore, the objective of this study was to perform a systematic review and meta-analysis on controlled clinical trials (RCT) assessing the effects of CLA supplementation on the circulating inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)...
December 29, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29287386/selective-synthesis-of-partial-glycerides-of-conjugated-linoleic-acids-via-modulation-of-the-catalytic-properties-of-lipases-by-immobilization-on-different-supports
#9
Carlos M Verdasco-Martín, Eduardo Garcia-Verdugo, Raul Porcar, Roberto Fernandez-Lafuente, Cristina Otero
Lipases B from Candida antarctica (CALB), Rhizomucor miehei (RML) and Thermomyces lanuginosus (TLL) were immobilized on octadecyl methacylate (OM) or octadecyl methacrylate (OMC) beads. Their specific activity and regioselectivity were studied in the synthesis of conjugated linoleic acid (CLA) partial glycerides, which presented nutraceutical properties. TLL derivatives were poor catalysts. Novozym® 435 was much better than Lipozyme® RM IM. RML activity (a GRAS enzyme) was modulated via immobilization. After only 3 h, OM-RML gave the highest CLA conversion (54% at 40 °C with 1:3 M ratio of glycerol to CLA)...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29248212/influence-of-conjugated-linoleic-acids-and-vitamin-e-on-biochemical-hematological-and-immunological-variables-of-dairy-cows-during-the-transition-period
#10
S Schäfers, D von Soosten, U Meyer, C Drong, J Frahm, A Tröscher, W Pelletier, H Sauerwein, S Dänicke
The objective of this experiment was to determine the effects of conjugated linoleic acid (CLA) and vitamin E as well as their interaction on biochemical and hematological variables and on leukocyte populations and their functionality. We assigned 59 German Holstein cows between the 2nd and 9th lactation to 4 dietary groups in a 2 × 2 factorial design with the factors CLA and vitamin E. Six weeks before calving the cows had a BCS of 3.7 to provoke a higher risk of developing ketosis, which might impair their immune function...
December 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29227097/interfacial-antioxidants-a-review-of-natural-and-synthetic-emulsifiers-and-co-emulsifiers-that-can-inhibit-lipid-oxidation
#11
David Julian McClements, Eric A Decker
There has been strong interest in developing effective strategies to inhibit lipid oxidation in emulsified food products due to the need to incorporate oxidatively labile bioactive lipids, such as w-3 fatty acids, conjugated linoleic acids, or carotenoids. Emulsifiers or co-emulsifiers can be utilized to inhibit lipid oxidation in emulsions. Both of these molecular types can adsorb to droplet surfaces and inhibit lipid oxidation, but emulsifiers can also stabilize droplets against aggregation whereas co-emulsifiers cannot...
December 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29224879/plant-oil-supplements-reduce-methane-emissions-and-improve-milk-fatty-acid-composition-in-dairy-cows-fed-grass-silage-based-diets-without-affecting-milk-yield
#12
A R Bayat, I Tapio, J Vilkki, K J Shingfield, H Leskinen
Four lipid supplements varying in chain length or degree of unsaturation were examined for their effects on milk yield and composition, ruminal CH4 emissions, rumen fermentation, nutrient utilization, and microbial ecology in lactating dairy cows. Five Nordic Red cows fitted with rumen cannulas were used in a 5 × 5 Latin square with five 28-d periods. Treatments comprised total mixed rations based on grass silage with a forage-to-concentrate ratio of 60:40 supplemented with no lipid (CO) or 50 g/kg of diet dry matter (DM) of myristic acid (MA), rapeseed oil (RO), safflower oil (SO), or linseed oil (LO)...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29219061/effect-of-conjugated-linoleic-acid-supplementation-on-serum-leptin-concentration-a-systematic-review-and-meta-analysis
#13
Fahimeh Haghighatdoost, Mitra Hariri
BACKGROUND: There are controversies regarding the effect of conjugated linoleic acid (CLA) on serum leptin. OBJECTIVE: To conduct a meta-analysis of randomized controlled trials (RCTs) to assess the effect of CLA on serum leptin concentrations. METHOD: Databases such as Ovid, PubMed/Medline, SCOPUS, Google Scholar, and ISI databases up to January 2017 were searched. The searches included RCTs conducted among human adults, and studies on the effect of conjugated linoleic acid on serum leptin concentrations as outcome variables...
December 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29198243/maternal-grazing-on-stubble-and-mediterranean-shrubland-improves-meat-lipid-profile-in-light-lambs-fed-on-concentrates
#14
L Mateo, P Delgado, J Ortuño, S Bañón
Concentrates-fed lamb meat is often associated with an unfavourable lipid profile (high levels of saturated and/or n-6 polyunsaturated fatty acids; SFA and PUFA). For this reason, Spanish sheep producers from Mediterranean areas are turning to traditional grazing by ewes to obtain healthier lamb meat. The objective of this research was to determine the effects of maternal grazing on the fatty acid (FA) composition of weaned lamb meat. The ewes (Segureña breed) were allocated to two different rearing systems during pregnancy (5 months) and lactation (45 days): (i) feeding indoors on barley grain and lucerne pellets; (ii) grazing on cereal stubble, fallow land and seasonal pastures consisting of Mediterranean shrubs, herbs and trees...
December 4, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29178459/inflammatory-and-metabolic-responses-to-an-intramammary-lipopolysaccharide-challenge-in-early-lactating-cows-supplemented-with-conjugated-linoleic-acid
#15
J J Gross, L Grossen-Rösti, R Héritier, A Tröscher, R M Bruckmaier
Supplementation of dairy cows with trans-10, cis-12 conjugated linoleic acid (CLA) allows nutrient repartitioning despite an energy deficiency in early lactation, which might be a benefit for the immune system, too. In this study, we investigated potential nutrient sparing effects of CLA in early lactating cows with low plasma glucose concentrations exposed to an intramammary lipopolysaccharide (LPS) challenge. Fifteen multiparous Holstein cows were exposed to an intramammary LPS challenge in week 4 p.p. Eight cows (CLA) were supplemented daily with 70 g of lipid-encapsulated CLA (6...
November 26, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29173222/maternal-conjugated-linoleic-acid-modulates-tag-metabolism-in-adult-rat-offspring
#16
Jimena Lavandera, Carolina D Gerstner, Juliana Saín, Ana C Fariña, Marcela A González, Claudio A Bernal
Conjugated linoleic acid (CLA) might regulate the lipid depots in liver and adipose tissue. As there is an association between maternal nutrition, fat depots and risk of offspring chronic disease, the aim was to investigate the effect of maternal CLA consumption on TAG regulation and some inflammatory parameters in adult male rat offspring receiving or not receiving CLA. Female Wistar rats were fed control (C) or CLA-supplemented (1 %, w/w) diets during 4 weeks before and throughout pregnancy and lactation...
November 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29167408/conjugated-linoleic-acid-prevents-age-dependent-neurodegeneration-in-a-mouse-model-of-neuropsychiatric-lupus-via-the-activation-of-an-adaptive-response
#17
Antonio Monaco, Ida Ferrandino, Floriana Boscaino, Ennio Cocca, Luisa Cigliano, Francesco Maurano, Diomira Luongo, Maria Stefania Spagnuolo, Mauro Rossi, Paolo Bergamo
Oxidative stress is a key mediator of autoimmune/neurodegenerative disorders. The antioxidant/anti-inflammatory effect of a synthetic conjugated linoleic acid (CLA) mixture in MRL/MpJ-Faslpr mice (MRL/lpr), an animal model of neuropsychiatric lupus, was previously associated with the improvement of Nuclear factor-E2-related factor 2 (Nrf2) defences in the spleen and liver. However, little is known about the neuroprotective ability of CLA mixture. This study investigates the age-dependent progression of oxidative stress and the hyperactivation of redox-sensitive compensatory pathways (macroautophagy, Nrf2) in old/diseased MRL/lpr mice brains, and examines the effect produced by dietary CLA supplementation...
November 22, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29161323/correction-conjugated-linoleic-acid-administration-induces-amnesia-in-male-sprague-dawley-rats-and-exacerbates-recovery-from-functional-deficits-induced-by-a-controlled-cortical-impact-injury
#18
Rastafa I Geddes, Kentaro Hayashi, Quinn Bongers, Marlyse Wehber, Icelle M Anderson, Alex D Jansen, Chase Nier, Emily Fares, Gabrielle Farquhar, Amita Kapoor, Toni E Ziegler, Sivan Vadakkadath Meethal, Ian M Bird, Craig S Atwood
[This corrects the article DOI: 10.1371/journal.pone.0169494.].
2017: PloS One
https://www.readbyqxmd.com/read/29141135/the-fatty-acid-composition-of-lamb-liver-muscle-and-adipose-tissues-in-response-to-rumen-protected-conjugated-linoleic-acid-cla-supplementation-is-tissue-dependent
#19
Stefano Schiavon, Matteo Bergamaschi, Erika Pellattiero, Alberto Simonetto, Franco Tagliapietra
The tissue-specific response to rumen-protected conjugated linoleic acid supply (rpCLA) of liver, two muscles and three adipose tissues of heavy lambs was studied. Twenty-four lambs, 8 months old, divided into 4 groups of 6, were fed at libitum on a ration supplemented without or with a mixture of rpCLA. Silica and hydrogenated soybean oil was the rpCLA coating matrix. The lambs were slaughtered at 11 months of age. Tissues were collected and analysed for their FA profiles. The dietary rpCLA supplement had no influence on carcass fatness nor on the fat content of the liver and tissues, and had little influence on the FA profiles of these tissues...
November 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29132974/topical-electrophilic-nitro-fatty-acids-potentiate-cutaneous-inflammation
#20
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo
Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation...
November 10, 2017: Free Radical Biology & Medicine
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