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conjugated linolic acid

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https://www.readbyqxmd.com/read/28107949/a-microcalorimetry-study-on-the-oxidation-of-linoleic-acid-and-the-control-of-rancidity
#1
Nabil Haman, Andrea Romano, Mohammad Asaduzzaman, Giovanna Ferrentino, Franco Biasioli, Matteo Scampicchio
The oxidative deterioration of unsaturated lipids fatty acids is a great concern for the food industry as it is associated with the development of rancid off-odors and the reduction of food quality. This work describes the potential use of isothermal microcalorimetry to monitor the oxidation of linoleic acid, an important conjugated fatty acid responsible for the development of rancidity. The heat flow signal developed during the oxidation process reflects a multistep mechanism typical of radical chain reactions...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107087/comparison-of-fatty-acid-composition-in-selected-dietary-supplements-containing-conjugated-linoleic-acid
#2
Dorota Derewiaka, Klara Nestorowicz, Rafał Wołosiak
The market of pharmaceutical products is offering a wide range of supplements. Most of the consumers believe that these products will improve their state of health, but are they getting what they want and what they are paying for? The aim of the study was to evaluate the quality of selected dietary supplements containing conjugated linoleic acid (CLA). All supplements were available in the Warsaw markets and bought from pharmacies. Assessment of the quality of food supplements was achieved by analysis of fatty acid using gas chromatography coupled with a mass spectrometer...
January 20, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28096139/potential-health-benefits-of-combining-yogurt-and-fruits-based-on-their-probiotic-and-prebiotic-properties
#3
REVIEW
Melissa Anne Fernandez, André Marette
Fruit and yogurt have been identified individually as indicators of healthy dietary patterns. Fruits are relatively low in energy density and are an excellent source of antioxidants and prebiotic fibers and polyphenols, which can promote digestive health. Yogurt, on the other hand, is a nutrient-dense food that is a good source of dairy protein, calcium, magnesium, vitamin B-12, conjugated linoleic acid, and other key fatty acids. In addition, it contains beneficial bacterial cultures, making it a potential source of probiotics...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28095736/development-of-multifunctional-foods
#4
Koji Yamada
Foods contain various biologically active substances with extent physiological effects. Among them, some substances, such as dietary fibers, polyunsaturated fatty acids, and antioxidants, exert multiple activities. In addition, combinational uses of some components, such as sesamin and α-tocopherol, enhance their biological effects each other. The expression of multiple effect leads to the production of multifunctional foods which prevent the occurrence of various diseases. Furthermore, synergic effects between biologically active substances allow us to decrease the dose of each component, which lead to the improvement of safety and reduction of production cost of multifunctional foods...
January 18, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28088424/comparison-between-conjugated-linoleic-acid-and-essential-fatty-acids-in-preventing-oxidative-stress-in-bovine-mammary-epithelial-cells
#5
L Basiricò, P Morera, D Dipasquale, A Tröscher, U Bernabucci
Some in vitro and in vivo studies have demonstrated protective effects of conjugated linoleic acid (CLA) isomers against oxidative stress and lipid peroxidation. However, only a few and conflicting studies have been conducted showing the antioxidant potential of essential fatty acids. The objectives of the study were to compare the effects of CLA to other essential fatty acids on the thiol redox status of bovine mammary epithelia cells (BME-UV1) and their protective role against oxidative damage on the mammary gland by an in vitro study...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28078603/a-comparison-of-the-anti-inflammatory-effects-of-cis-9-trans-11-conjugated-linoleic-acid-to-celecoxib-in-the-collagen-induced-arthritis-model
#6
Jake M Olson, Alexander W Haas, Jennifer Lor, Holly S McKee, Mark E Cook
Cyclooxygenase (COX)-2 inhibitors, such as celecoxib, for chronic inflammatory disease are associated with adverse health events, while cis-9, trans-11 (c9t11) conjugated linoleic acid (CLA) is anti-inflammatory without adverse events attributed to pure intake. Mechanistically, celecoxib and c9t11 disrupt the arachidonic acid cascade; however, the equivalency of anti-inflammatory effects between these compounds is unknown. Therefore, to test the hypothesis that 0.5% dietary c9t11 reduces inflammation equivalently to a celecoxib dose intended to treat rheumatoid arthritis (RA; 5 mg/kg bw), arthritic mice received diets containing one of the following supplements: 1% corn oil (CO, w/w), 0...
January 11, 2017: Lipids
https://www.readbyqxmd.com/read/28074319/trans-fatty-acid-stimulated-mammary-gland-growth-in-ovariectomized-mice-is-fatty-acid-type-and-isomer-specific
#7
Grace E Berryhill, Susan G Miszewski, Josephine F Trott, Jana Kraft, Adam L Lock, Russell C Hovey
We previously reported that the trans-18:2 fatty acid trans-10, cis-12 conjugated linoleic acid (t10,c12-CLA) stimulates mammary gland development independent of estrogen and its receptor. Given the negative consequences of dietary trans-fatty acids on various aspects of human health, we sought to establish whether other trans-fatty acids could similarly induce ovary-independent mammary gland growth in mice. Prepubertal BALB/cJ mice were ovariectomized at 21 days of age then were fed diets enriched with cis-9, trans-11 CLA (c9,t11-CLA), or mixtures of trans-18:1 fatty acids supplied by partially hydrogenated sunflower, safflower, or linseed oil...
January 10, 2017: Lipids
https://www.readbyqxmd.com/read/28070532/evaluation-of-scd-and-fasn-gene-expression-in-baluchi-iran-black-and-arman-sheep
#8
Salmani Izadi Mohammad, Naserian Abbas Ali, Nasiri Mohammad Reza, Majidzadeh Heravi Reza, Valizadeh Reza
BACKGROUND: With the increasing concern for health and nutrition, dietary fat has attracted considerable attention. The composition of fatty acids in the diet is important because they are associated with major diseases including cancers, diabetes, and cardiovascular disease. The fatty acid synthase (FASN) and stearoyl-CoA desaturase (delta-9-desaturase) (SCD) genes affect fatty acid composition (1). The expression of SCD and FASN genes is related to an increase in conjugated linoleic acid (CLA) in dairy products, which benefits human health...
October 2016: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28045194/the-effect-of-increasing-levels-of-date-palm-phoenix-dactylifera-l-seed-on-the-performance-ruminal-fermentation-antioxidant-status-and-milk-fatty-acid-profile-of-saanen-dairy-goats
#9
M Sharifi, M Bashtani, A A Naserian, H Farhangfar
This study was conducted to examine the effect of date palm (Phoenix dactylifera L.) seed (DPS) on the performance, ruminal fermentation, antioxidant status and milk fatty acid (FA) profile of dairy goats. Eight multiparous Saanen dairy goats, averaging 97 ± 7 days in milk (DIM) and 2150 ± 130 g of milk production, were used in a 4 × 4 replicated Latin square design. Experimental diets contained 0% (control), 6% (DPS6), 12% (DPS12) and 18% (DPS18) of DPS. Dry matter intake (DMI), milk production, and the composition and digestibility of the dry matter (DM), organic matter (OM), neutral detergent fibre (NDF) and crude protein (CP) were not affected by the diets...
January 3, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28038897/herbal-supplements-association-with-reversible-cerebral-vasoconstriction-syndrome-a-case-report
#10
Isabel Costa, Marcelo D Mendonça, Vera Cruz E Silva, Sofia Calado, Miguel Viana-Baptista
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a clinico-radiologic syndrome characterized by thunderclap headache and reversible multifocal arterial constrictions that resolves within 3 months. RCVS can be either spontaneous or related to a trigger; vasoactive drugs including over-the-counter medicine are common culprits. Nevertheless, there are sparse data on the association of herbal supplements in the genesis of unexplained RCVS. METHODS: We describe a case of RCVS with a temporal association with the consumption of a diet pill composed of green tea, L-carnitine, and conjugated linoleic acid...
December 27, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27988126/effect-of-high-oleic-acid-soybeans-on-production-performance-milk-fatty-acid-composition-and-enteric-methane-emission-in-dairy-cows
#11
J C Lopes, M T Harper, F Giallongo, J Oh, L Smith, A M Ortega-Perez, S A Harper, A Melgar, D M Kniffen, R A Fabin, A N Hristov
The objective of this study was to investigate the effect of 3 soybean sources differing in fatty acid profile and processing method on productivity, milk composition, digestibility, rumen fermentation, and enteric methane emission in lactating dairy cows. The soybean sources were conventional, high-linoleic-acid variety extruded soybean meal (ESBM; 8.7% ether extract with 15% oleic and 54% linoleic acids); extruded Plenish (DuPont Pioneer, Johnston, IA), high-oleic-acid variety soybean meal (EPSBM; 8.4% ether extract with 73% oleic and 8% linoleic acids); and whole, heated Plenish soybeans (WPSB; 20...
December 14, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27930681/transcriptomic-changes-in-liver-of-young-bulls-caused-by-diets-low-in-mineral-and-protein-contents-and-supplemented-with-n-3-fatty-acids-and-conjugated-linoleic-acid
#12
Sara Pegolo, Alessio Cecchinato, Núria Mach, Massimiliano Babbucci, Marianna Pauletto, Luca Bargelloni, Stefano Schiavon, Giovanni Bittante
The aim of the present study was to identify transcriptional modifications and regulatory networks accounting for physiological and metabolic responses to specific nutrients in the liver of young Belgian Blue × Holstein bulls using RNA-sequencing. A larger trial has been carried out in which animals were fed with different diets: 1] a conventional diet; 2] a low-protein/low-mineral diet (low-impact diet) and 3] a diet enriched in n-3 fatty acids (FAs), conjugated linoleic acid (CLA) and vitamin E (nutraceutical diet)...
2016: PloS One
https://www.readbyqxmd.com/read/27924729/conjugated-linoleic-acid-isomers-exert-differential-effects-on-an-adipocyte-model-of-hiv-associated-lipodystrophy
#13
Cathríona R Loonam, Sandra D O Dell, Anne Mullen
BACKGROUND: HIV-associated lipodystrophy is associated with decreased expression of PPAR-γ in adipose tissue. Conjugated linoleic acid (CLA) isomers (cis9, trans11 and trans10, cis12) are putative PPAR-γ agonists, but have not previously been investigated in the context of HIV-associated lipodystrophy. METHODS: 3T3-L1 pre-adipocytes were differentiated in the presence of ritonavir (20 μM as per previous experimental models) and 100 μM cis9,trans11, trans10,cis12 or vehicle control, DMSO...
December 7, 2016: Current HIV Research
https://www.readbyqxmd.com/read/27923813/the-chemical-basis-of-thiol-addition-to-nitro-conjugated-linoleic-acid-a-protective-cell-signaling-lipid
#14
Lucia Turell, Dario A Vitturi, E Laura Coitiño, Lourdes Lebrato, Matias N Moller, Camila Sagasti, Sonia R Salvatore, Steven R Woodcock, Beatriz Alvarez, Francisco J Schopfer
Nitroalkene fatty acids are formed in vivo and exert protective and anti-inflammatory effects via reversible Michael addition to thiol-containing proteins in key signaling pathways. Nitro-conjugated linoleic acid (NO2-CLA) is preferentially formed, constitutes the most abundant nitrated fatty acid in humans and contains two carbons that could potentially react with thiols, modulating signaling actions and levels. In this work, we examined the reactions of NO2-CLA with low molecular weight thiols (glutathione, cysteine, homocysteine, cysteinylglycine and β mercaptoethanol) and human serum albumin (HSA)...
December 6, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27913584/nitro-fatty-acid-pharmacokinetics-in-the-adipose-tissue-compartment
#15
Marco Fazzari, Nicholas K H Khoo, Steven R Woodcock, Diane K Jorkasky, Lihua Li, Francisco J Schopfer, Bruce A Freeman
Electrophilic nitro-fatty acids (NO2-FAs) promote adaptive and anti-inflammatory cell signaling responses as a result of an electrophilic character that supports post-translational protein modifications. A unique pharmacokinetic profile is expected for NO2-FAs because of an ability to undergo reversible reactions including Michael additions with biological cysteine-containing proteins and esterification into complex lipids. Herein we report via quantitative whole-body autoradiography analysis of rats gavaged with radiolabeled 10-nitro-[14C]oleic acid, preferential accumulation in adipose tissue over two weeks...
December 2, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27898407/expression-pattern-and-regulatory-role-of-microrna-23a-in-conjugated-linoleic-acids-induced-apoptosis-of-adipocytes
#16
Renli Qi, Qi Wang, Jing Wang, Jinxiu Huang, Shan Jiang, Rong Xiao, Zuohua Liu, Feiyun Yang
BACKGROUND/AIMS: Conjugated linoleic acids (CLAs) are known to induce apoptosis in adipocytes; however, the cellular mechanisms involved remained illdefined. We explored the different apoptotic induction effects of two CLA isomers on adipocytes and then investigated the expression and function of microRNAs (miRNAs) related to the apoptosis. METHODS: TUNEL and FCM assays were used to detect CLAs-induced adipocyte apoptosis. Microarrays were used to compare the differential expression of miRNAs...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27897090/the-effect-of-commercial-conjugated-linoleic-acid-products-on-experimental-periodontitis-and-diabetes-mellitus-in-wistar-rats
#17
COMPARATIVE STUDY
Hatice Balci Yuce, Nihat Akbulut, Seda Ocakli, Omer Kayir, Mahfuz Elmastas
OBJECTIVE: The aim of present study was to determine the effects of conjugated linoleic acid enriched milk on alveolar bone loss, hyperglycaemia, oxidative stress and apoptosis in ligature-induced periodontal disease in diabetic rat model. METHODS: Wistar rats were divided into six experimental groups: 1; non-ligated (NL, n = 6) group, 2; ligature only (LO, n = 6) group, 3; streptozotocin only (STZ, n = 8) group, 4; STZ and ligature (STZ + L, n = 8) group, 5; ligature and conjugated linoleic acid (CLA) (L + CLA, n = 8) group, 6; STZ, ligature and CLA group (STZ + L + CLA, n = 8) group...
January 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27884102/gene-expression-profile-of-intramuscular-muscle-in-nellore-cattle-with-extreme-values-of-fatty-acid
#18
Mariana P Berton, Larissa F S Fonseca, Daniela F J Gimenez, Bruno L Utembergue, Aline S M Cesar, Luiz L Coutinho, Marcos Vinicius A de Lemos, Carolyn Aboujaoude, Angélica S C Pereira, Rafael M de O Silva, Nedenia B Stafuzza, Fabieli L B Feitosa, Hermenegildo L J Chiaia, Bianca F Olivieri, Elisa Peripolli, Rafael L Tonussi, Daniel M Gordo, Rafael Espigolan, Adrielle M Ferrinho, Lenise F Mueller, Lucia G de Albuquerque, Henrique N de Oliveira, Susan Duckett, Fernando Baldi
BACKGROUND: Fatty acid type in beef can be detrimental to human health and has received considerable attention in recent years. The aim of this study was to identify differentially expressed genes in longissimus thoracis muscle of 48 Nellore young bulls with extreme phenotypes for fatty acid composition of intramuscular fat by RNA-seq technique. RESULTS: Differential expression analyses between animals with extreme phenotype for fatty acid composition showed a total of 13 differentially expressed genes for myristic (C14:0), 35 for palmitic (C16:0), 187 for stearic (C18:0), 371 for oleic (C18:1, cis-9), 24 for conjugated linoleic (C18:2 cis-9, trans11, CLA), 89 for linoleic (C18:2 cis-9,12 n6), and 110 genes for α-linolenic (C18:3 n3) fatty acids...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27878919/effect-of-health-status-on-fattening-performance-in-young-crossbred-polish-holstein-friesian-%C3%A3-limousin-bulls-and-steers
#19
Zofia Wielgosz-Groth, Monika Sobczuk-Szul, Zenon Nogalski, Paulina Pogorzelska-Przybyłek, Cezary Purwin
The aim of this study was to determine the effect of disease incidence on selected parameters of cattle fattening performance and carcass quality, and the fatty acid profile of beef. The experimental materials comprised 16 bulls and 16 steers, Polish Holstein-Friesian × Limousin crossbreeds (including 10 healthy and six treated animals of each category). At 5 weeks of age, bloodless castration was carried out using a rubber elastrator. The calves were fed milk replacer provided in automatic feeding stations...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27878911/effect-of-increased-feeding-of-dietary-%C3%AE-linolenic-acid-by-grazing-on-formation-of-the-cis9-trans11-18-2-isoform-of-conjugated-linoleic-acid-in-bovine-milk
#20
Mio Yamaguchi, Taki Naito, Yoshikazu Nagao, Yukihito Kabuyama, Kei Hashimoto, Norihiro Azuma, Isamu Maeda
Feeding systems such as grazing affect the fatty acid profile of bovine milk fat. In addition, milk fat is formed as the product of fatty acid metabolism in cow bodies before being secreted into milk. However, how grazing influences milk fatty acid profile through the metabolism has not been completely characterized. When fatty acid concentrations in Holstein milk were compared between grazing and non-grazing periods, α-linolenic acid was significantly higher in the grazing period than in the non-grazing period...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
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