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conjugated linolic acid

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https://www.readbyqxmd.com/read/28815782/influence-of-conjugated-linoleic-acids-and-vitamin-e-on-milk-fatty-acid-composition-and-concentrations-of-vitamin-a-and-%C3%AE-tocopherol-in-blood-and-milk-of-dairy-cows
#1
S Schäfers, U Meyer, D von Soosten, L Hüther, C Drong, K Eder, E Most, A Tröscher, W Pelletier, A Zeyner, S Dänicke
The objective of this trial was to investigate the influences of conjugated linoleic acid (CLA) and vitamin E (Vit. E) and their interactions on fatty acid composition and vitamins in milk (α-tocopherol, retinol and β-carotene) as well as on α-tocopherol in blood of pluriparous cows from week 6 ante partum until week 10 post-partum (p.p.). We assigned 59 pluriparous German Holstein cows to four treatment groups with the treatment factors CLA and Vit. E at two levels in a 2 × 2 factorial design. Milk fatty acid composition and milk vitamins were analysed on lactation days 7 and 28...
August 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28804001/production-of-trans-and-conjugated-fatty-acids-in-dairy-ruminants-and-their-putative-effects-on-human-health-a-review
#2
REVIEW
Anne Ferlay, Laurence Bernard, Annabelle Meynadier, Corinne Malpuech-Brugère
Consumption of milk and dairy products is important in Western industrialised countries. Fat content is an important constituent contributing to the nutritional quality of milk and dairy products. In order to improve the health of consumers, there is high interest in improving their fatty acid (FA) composition, which depends principally on rumen and mammary metabolism. This paper reviews the lipid metabolism in ruminants, with a particular focus on the production of trans and conjugated linoleic acids (CLA) and conjugated linolenic acids (CLnA) in the rumen...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28795443/effect-of-conjugated-linoleic-acids-and-omega-3-fatty-acids-with-or-without-resistance-training-on-muscle-mass-in-high-fat-diet-fed-middle-aged-mice
#3
Sang-Rok Lee, Andy V Khamoui, Edward Jo, Michael C Zourdos, Lynn B Panton, Michael J Ormsbee, Jeong-Su Kim
This study investigated the effects of 20 weeks of combined conjugated linoleic acid/omega-3 fatty acid (n-3) administration independently or combined with resistance exercise training (RET) muscle in middle-aged mice consuming a high-fat diet (HFD). Nine-month-old C57BL/6 mice were randomly assigned into four experimental groups (H: high-fat diet, HE: H + RET, HCN: H + CLA/n-3, and HECN: H + CLA/n3 + RET). Body composition and functional capacity were assessed at pre- and post-intervention. Muscle tissues were collected at 14 months of age...
August 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28771065/acrolein-induced-oxidative-stress-and-genotoxicity-in-rats-protective-effects-of-whey-protein-and-conjugated-linoleic-acid
#4
Birsen Aydın, Zülal Atlı Şekeroğlu, Vedat Şekeroğlu
Acrolein (AC), a highly reactive hazardous pollutant, poses serious threats to human health. Whey protein (WP) and conjugated linoleic acid (CLA) have beneficial health implications. We investigated the protective effects of WP and CLA against AC-induced toxicity in rats. The animals were orally gavaged with CLA (200 mg/kg/day), WP (200 mg/kg/day), AC (5 mg/kg/day), CLA + AC (200 + 5 mg/kg/day), and WP + AC (200 + 5 mg/kg/day) six days per week for 30 days. The oral administration of AC significantly induced oxidative stress by increasing thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCOs) levels and decreasing glutathione (GSH) level in the spleen, thymus, and polymorphonuclear leukocytes (PMNs)...
August 3, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28763005/seasonal-variation-in-fat-quality-and-conjugated-linoleic-acid-content-of-dairy-products-from-the-tropics-evidence-of-potential-impact-on-human-health
#5
Juliana Côrtes Nunes, Monalisa Nilza Lole Ramalho da Silva, Daniel Perrone, Alexandre Guedes Torres
Seasonal variation in conjugated linoleic acid (CLA) content and atherogenicity index (AI) of retail dairy products (whole milk, butter, and prato, a soft yellow cheese) from Brazil was investigated. CLA content of dairy products ranged from 0.55 to 1.53 g CLA/100 g fatty acids and was on average 25% higher during the rainy season compared to the dry season. Dairy products from the rainy season also had lower AI levels, indicating a lower risk of causing cardiovascular disease in consumers. This seasonality led to estimated seasonal variations of milk fat quality consumed by the population of southeastern Brazil, meaning 15% and 19% variation in daily intake of CLA and AI values, respectively...
August 1, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28752804/one-pot-conjugated-linoleic-acid-production-from-castor-oil-by-rhizopus-oryzae-lipase-and-resting-cells-of-lactobacillus-plantarum
#6
Abid Ali Khaskheli, Farah Naz Talpur, Aysun Cebeci Aydin, Sana Jawaid, Muhammad Ali Surhio, Hassan Imran Afridi
Conjugated linoleic acid (CLA) has attracted as novel type of fatty acids having unusual health-promoting properties such as anticarcinogenic and antiobesitic effects. The present work employed castor oil as substrate for one-pot production of CLA using washed cells of Lactobacillus plantarum (L. plantarum) and lipases as catalysts. Among the screened lipases, the lipase Rhizopus oryzae (ROL) greatly assisted resting cells to produce CLA. Mass spectral analysis of the product showed that two major isomers of CLA were produced in the reaction mixture i...
July 28, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28752254/interaction-between-c18-fatty-acids-and-dope-peg2000-in-langmuir-monolayers-effect-of-degree-of-unsaturation
#7
Lai Ti Gew, Misni Misran
In this study, we address the effect of the cis-double bond in 1,2-dioleoyl-sn-glycero-3-phosphoethanolamide-N-[methoxy(polyethylene glycol)-2000, DOPE PEG2000 (DP), on the Langmuir monolayer of C18 fatty acids-namely, stearic acid (SA), oleic acid (L1), linoleic acid (L2), and linolenic acid (L3)-with the same head group but different degrees of saturation on their hydrocarbon chains. Negative values of Gibbs free energy of mixing (ΔG mix) were obtained throughout the investigated ranges of the unsaturated C18 fatty-acid (L1, L2 and L3) mixed systems, indicating that very strong attractions occurred between molecules in the monolayers...
July 27, 2017: Journal of Biological Physics
https://www.readbyqxmd.com/read/28751679/conjugated-linoleic-acid-supplementation-improves-maternal-high-fat-diet-induced-programming-of-metabolic-dysfunction-in-adult-male-rat-offspring
#8
Stephanie A Segovia, Mark H Vickers, Clint Gray, Xiaoyuan D Zhang, Clare M Reynolds
The developmental origins of health and disease hypothesis proposes that an adverse early life environment, including in utero exposure to a maternal obesogenic environment, can lead to an increased long-term risk of obesity and related metabolic complications in offspring. We assessed whether maternal supplementation with conjugated linoleic acid (CLA) could prevent some of these adverse effects in offspring exposed to a maternal high fat diet. Sprague-Dawley dams consumed either a: control (CD), control with CLA (CLA), high fat (HF) or high fat with CLA (HFCLA) diet 10 days prior to mating and throughout pregnancy/lactation...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740278/effects-of-deep-fat-frying-process-on-the-oil-quality-during-french-fries-preparation
#9
Ruhollah Sayyad
The performance of the sunflower oil in deep-fat frying was assessed by evaluating the efficacy of linoleic acid level and composition of tocopherol isomeric on its frying stability. The oil was used as a frying media to fry potato strips for 6 h daily for 7 days. Standard procedures for the measurement of used frying oil degradation such as fatty acid composition, acid value, anisidine value, conjugated diene value, total polar compounds and tocopherol concentration were used. At analogous composition of tocopherol isomers, the high oleic sunflower oil with smaller value of linoleic acid content indicated higher frying stability than the oil with higher linoleic acid level...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28739973/conjugated-linoleic-acid-modulates-clinical-responses-to-oral-nitrite-and-nitrate
#10
Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin
Dietary NO3(-) (nitrate) and NO2(-) (nitrite) support (·)NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3(-)and NO2(-)metabolism and the impact of dietary lipid on nitrogen oxide metabolism and cardiovascular responses, the stable isotopes Na(15)NO3 and Na(15)NO2 were orally administered in the presence or absence of conjugated linoleic acid (cLA)...
July 24, 2017: Hypertension
https://www.readbyqxmd.com/read/28735560/promotion-of-fracture-healing-by-conjugated-linoleic-acid-in-rats
#11
Zhongshu Shan, Zong-Ping Luo, Xiaozhong Shen, Liang Chen
BACKGROUND: The ability of fracture healing in Tibetans is significantly superior to Chinese Hans, which may attribute to factors from diet, altitude to physical conditions. Conjugated linoleic acid (CLA) is an important ingredient in Tibetan diet, playing a role in antioxidation, antiatherosclerosis, and decrease in body fat accumulation.  Methods: This study further quantified CLA effect in fracture healing in rats using combined structural evaluation (X-ray and micro-computed tomography), biomechanical test, and histological examination...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28728359/influence-of-supplemental-canola-or-soybean-oil-on-milk-yield-fatty-acid-profile-and-postpartum-weight-changes-in-grazing-dairy-goats
#12
Israel Lerma-Reyes, G D Mendoza-Martínez, Rolando Rojo-Rubio, Mario Mejia, Juan Carlos Garcia-Lopez, Hector Aaron Lee-Rangel
Objective: This experiment was designed to evaluate the effect of supplementation with soybean or canola oil on milk production and the composition of long chain fatty acids as well as weight changes in the goats and their kids. Methods: Thirty nine mulitparous crossed Alpine x Nubian goats (initial BW 43.5 ± 1.7 kg) from the day of parturition were assigned to the treatments: grazing control (n=15); grazing plus 20 mL/goat/d of supplemental soybean oil (n=12); and grazing plus 20 mL/goat/d of supplemental canola oil (n=12)...
June 27, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28720932/investigating-the-amount-of-tfas-clas-and-%C3%AF-6-%C3%AF-3-of-various-brands-of-corn-oil-heated-at-different-time-temperature-treatments
#13
Fan He, Qin Guo, Fengying Gu, Yiming Ha, Wei Gong, Feng Wang
A qualitative and quantitative analysis of trans fatty acids (TFAs), conjugated linoleic acids (CLAs) and linoleic acid/α-linolenic acid (ω6/ω3) in eleven different brands of fresh and heated corn oil was investigated. Corn oil was subjected to thermal treatment at 180, 210 and 230 °C for 4, 8 and 12 h. The kinds of fatty acids were almost the same in all eleven brands of corn oil, but there were differences in the quantities of TFAs, CLAs and ω6/ω3 among the brands. The formation of TFAs in different brands of corn oil increased slowly at 180 °C and rapidly at 230 °C with the maximum increase of 28 and 374%, respectively...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28689379/-influence-of-conjugated-linoleic-acids-on-metabolic-processes-in-cells-and-tissues
#14
Ewa Siwiec, Ewa Stachowska
Conjugated linoleic acids (CLA) are constitutional and geometric isomers of this acid. The most commonly consumed geometric isomers are cis-9,trans-11 (c9, t11) CLA and trans-10, cis-12 (t10,c12) CLA. These isomers together with trans-9,trans-11 CLA and trans-10,trans-12 CLA constitute about 90% of all CLA in natural products. Different structure of the isomers affects their functions in the body. Differences in the effects on organs and tissues are sometimes small and sometimes opposed, sometimes the isomers work synergistically...
2017: Postepy Biochemii
https://www.readbyqxmd.com/read/28688615/innovative-dairy-cow-management-to-improve-resistance-to-metabolic-and-infectious-diseases-during-the-transition-period
#15
REVIEW
P Lacasse, N Vanacker, S Ollier, C Ster
The incidence of metabolic and infectious diseases varies greatly during the lactation cycle. Most new cases of clinical mastitis appear at the beginning of lactation, and the incidence increases with the level of milk production. In addition to mastitis, many other infectious diseases become clinically apparent during the first 2weeks of lactation. During this time, cows are in a negative energy balance and must mobilize body reserves to balance the deficit between food energy intake and energy required for milk production...
June 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28672978/oral-administration-of-lactobacilli-isolated-from-jeotgal-a-salted-fermented-seafood-inhibits-the-development-of-2-4-dinitrofluorobenzene-induced-atopic-dermatitis-in-mice
#16
Mi-Sung Park, Nho-Eul Song, Sang-Ho Baik, Hyun-Ock Pae, Seong Hoon Park
Certain strains of lactobacilli have been reported to exert favorable effects on atopic dermatitis (AD). Jeotgal, a traditional Korean food, is a salted fermented seafood known to harbor many lactic acid bacteria. In the present study, two novel lactobacillus strains were isolated from Jeotgal, and their anti-AD effects were investigated. Lactobacilli isolated from Jeotgal were identified, according to conjugated linoleic acid-producing activity, as Lactobacillus plantarum (JBCC105645 and JBCC105683). AD-like skin lesions were induced in BALB/c mice using dinitrofluorobenzene (DNFB)...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28651330/rosiglitazone-improves-insulin-resistance-mediated-by-10-12-conjugated-linoleic-acid-in-a-male-mouse-model-of-metabolic-syndrome
#17
Shari Wang, Leela Goodspeed, Katherine E Turk, Barbara Houston, Laura J den Hartigh
Trans-10, cis-12 conjugated linoleic acid (10,12 CLA) is a dietary fatty acid that promotes weight loss and disproportionate fat loss. Obese mice fed a high fat high sucrose (HFHS) diet containing 10,12 CLA are resistant to weight gain and contain markedly reduced subcutaneous fat and adiponectin, with a concurrent lack of improvement in insulin sensitivity despite significant weight loss. Taken together, 10,12 CLA promotes a phenotype resembling PPARγ antagonism. Since thiazolidinediones such as rosiglitazone (Rosi) are used clinically to improve insulin sensitivity by activating PPARγ, with particular efficacy in subcutaneous white adipose tissue, we hypothesized that Rosi would improve glucose metabolism in mice losing weight with 10,12 CLA...
June 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/28647365/conjugated-linoleic-acid-prevents-age-induced-bone-loss-in-mice-by-regulating-both-osteoblastogenesis-and-adipogenesis
#18
Guanlin Lin, Huan Wang, Jun Dai, Xiao Li, Ming Guan, Shutao Gao, Qing Ding, Huaixi Wang, Huang Fang
Osteoporosis (OP) can increase the risk of bone fracture and other complications, which is a major clinical problem. Previous researches have revealed that conjugated linoleic acid (CLA) can promote the bone formation. But the mechanisms are not clear. Thus, we tested the hypothesis that CLA acts on bone formation might be via mTOR Complex1 (mTORC 1) pathway by in vitro and vivo assays. We studied the effect of CLA mix on MC3T3-E1 pre-osteoblasts differentiation into osteoblasts, and bone formation under osteoporotic conditions...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28631807/compositional-analyses-and-shelf-life-modeling-of-njangsa-ricinodendron-heudelotii-seed-oil-using-the-weibull-hazard-analysis
#19
Harold K Abaidoo-Ayin, Prince G Boakye, Kerby C Jones, Victor T Wyatt, Samuel A Besong, Stephen E Lumor
This study investigated the compositional characteristics and shelf-life of Njangsa seed oil (NSO). Oil from Njangsa had a high polyunsaturated fatty acid (PUFA) content of which alpha eleostearic acid (α-ESA), an unusual conjugated linoleic acid was the most prevalent (about 52%). Linoleic acid was also present in appreciable amounts (approximately 34%). Our investigations also indicated that the acid-catalyzed transesterification of NSO resulted in lower yields of α-ESA methyl esters, due to isomerization, a phenomenon which was not observed under basic conditions...
June 20, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28627455/gemcitabine-vitamin-e-conjugates-synthesis-characterization-entrapment-into-nanoemulsions-and-in-vitro-deamination-and-antitumor-activity
#20
Ahmed Abu-Fayyad, Sami Nazzal
Gemcitabine is the first line therapy for pancreatic cancer. It is, however, extensively metabolized to the inactive form by deamination enzymatic reaction. Conjugation of gemcitabine with fatty acids on its 4-amino group was found to protect it from deamination deactivation reaction. The objective of the present study was to test the in-vitro anticancer activity of gemcitabine conjugated to the γ-tocotrienol isomer of vitamin E against pancreatic tumor cells. This objective was based on reported studies in which it was demonstrated that free tocotrienol isomers of vitamin E can potentiate the anticancer activity of gemcitabine...
August 7, 2017: International Journal of Pharmaceutics
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