Henrieta Papúchová, Malene Hviid Saxtorph, Trine Hallager, Ida E Jepsen, Jens O Eriksen, Gry Persson, Tina Funck, Iben Weisdorf, Nicholas S Macklon, Lise Grupe Larsen, Thomas Vauvert F Hviid
STUDY QUESTION: Is human leukocyte antigen (HLA)-F protein expressed in mid-secretory endometrium, and are its expression levels influenced by HLA-F gene polymorphisms and correlated with the abundance of uterine natural killer (uNK) cells and anti-inflammatory M2 macrophages? SUMMARY ANSWER: HLA-F protein is expressed in mid-secretory endometrium, and levels are correlated with immune cell infiltration, plasma progesterone concentrations and HLA-F single-nucleotide polymorphisms (SNPs), however, women experiencing recurrent implantation failure (RIF) show differences when compared to women attending their first IVF treatment...
July 30, 2022: Human Reproduction