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endometrial receptivity array

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https://www.readbyqxmd.com/read/27717732/evidence-that-the-endometrial-microbiota-has-an-effect-on-implantation-success-or-failure
#1
Inmaculada Moreno, Francisco M Codoñer, Felipe Vilella, Diana Valbuena, Juan F Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon
BACKGROUND: Bacterial cells in the human body account for 1-3% of total body weight and are at least equal in number to human cells. Recent research has focused on understanding how the different bacterial communities in the body (eg, gut, respiratory, skin, and vaginal microbiomes) predispose to health and disease. The microbiota of the reproductive tract has been inferred from the vaginal bacterial communities, and the uterus has been classically considered a sterile cavity. However, while the vaginal microbiota has been investigated in depth, there is a paucity of consistent data regarding the existence of an endometrial microbiota and its possible impact in reproductive function...
December 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27365540/diagnosis-of-endometrial-factor-infertility-current-approaches-and-new-avenues-for-research
#2
REVIEW
N Katzorke, F Vilella, M Ruiz, J-S Krüssel, C Simón
Over the last decade, research to improve success rates in reproductive medicine has focused predominantly on the understanding and optimization of embryo quality. However, the emergence of personalized medicine in ovulation induction and embryology has shifted the focus to assessing the individual status of the endometrium. The endometrium is considered receptive during an individually defined period, the window of implantation (WOI), when the mother permits a blastocyst to attach and implant. This individual receptivity status can now be objectively diagnosed using the endometrial receptivity array (ERA) developed in 2011...
June 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27122490/intrauterine-human-chorionic-gonadotropin-infusion-in-oocyte-donors-promotes-endometrial-synchrony-and-induction-of-early-decidual-markers-for-stromal-survival-a-randomized-clinical-trial
#3
Michael R Strug, Renwei Su, James E Young, William G Dodds, Valerie I Shavell, Patricia Díaz-Gimeno, Maria Ruíz-Alonso, Carlos Simón, Bruce A Lessey, Richard E Leach, Asgerally T Fazleabas
STUDY QUESTION: Does a single intrauterine infusion of human chorionic gonadotropin (hCG) at the time corresponding to a Day 3 embryo transfer in oocyte donors induce favorable molecular changes in the endometrium for embryo implantation? SUMMARY ANSWER: Intrauterine hCG was associated with endometrial synchronization between endometrial glands and stroma following ovarian stimulation and the induction of early decidual markers associated with stromal cell survival...
July 2016: Human Reproduction
https://www.readbyqxmd.com/read/27110071/the-endometrium-in-assisted-reproductive-technology-how-thin-is-thin
#4
REVIEW
Nalini Mahajan, S Sharma
A thin endometrium is encountered infrequently (2.4%) in assisted reproductive technology cycles. When it does occur it is a cause of concern as it is associated with lower implantation rate and pregnancy rate. Though pregnancies have been reported at 4 and 5 mm it is apparent that an endometrial thickness <6 mm is associated with a trend toward lower probability of pregnancy. Hormone replacement therapy - frozen embryo transfer (FET) cycles appear to give better results due to an improvement in endometrial receptivity (ER)...
January 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/26965375/clinical-and-subclinical-endometritis-induced-alterations-in-bovine-endometrial-transcriptome-and-mirnome-profile
#5
Dessie Salilew-Wondim, Sally Ibrahim, Samuel Gebremedhn, Dawit Tesfaye, Maike Heppelmann, Heinrich Bollwein, Christiane Pfarrer, Ernst Tholen, Christiane Neuhoff, Karl Schellander, Michael Hoelker
BACKGROUND: Clinical and subclinical endometritis are known to affect the fertility of dairy cows by inducing uterine inflammation. We hypothesized that clinical or subclinical endometritis could affect the fertility of cows by disturbing the molecular milieu of the uterine environment. Here we aimed to investigate the endometrial molecular signatures and pathways affected by clinical and subclinical endometritis. For this, Holstein Frisian cows at 42-60 days postpartum were classified as healthy (HE), subclinical endometritis (SE) or clinical endometritis (CE) based on veterinary clinical examination of the animals and histological evaluation the corresponding endometrial biopsies...
2016: BMC Genomics
https://www.readbyqxmd.com/read/26945096/local-and-systemic-factors-and-implantation-what-is-the-evidence
#6
REVIEW
Chelsea Fox, Scott Morin, Jae-Wook Jeong, Richard T Scott, Bruce A Lessey
Significant progress has been made in the understanding of embryonic competence and endometrial receptivity since the inception of assisted reproductive technology. The endometrium is a highly dynamic tissue that plays a crucial role in the establishment and maintenance of normal pregnancy. In response to steroid sex hormones, the endometrium undergoes marked changes during the menstrual cycle that are critical for acceptance of the nascent embryo. There is also a wide body of literature on systemic factors that impact assisted reproductive technology outcomes...
April 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26645573/controlled-ovarian-hyperstimulation-induced-changes-in-the-expression-of-circulatory-mirna-in-bovine-follicular-fluid-and-blood-plasma
#7
Sina Seifi Noferesti, Md Mahmodul Hasan Sohel, Michael Hoelker, Dessie Salilew-Wondim, Ernst Tholen, Christian Looft, Franca Rings, Christiane Neuhoff, Karl Schellander, Dawit Tesfaye
BACKGROUND: Despite its role in increasing the number of offspring during the lifetime of an individual animal, controlled ovarian hyperstimulation (COH) may have detrimental effects on oocyte development, embryo quality and endometrial receptivity. Circulating miRNAs in bio-fluids have been shown to be associated with various pathological conditions including cancers. Here we aimed to investigate the effect of COH on the level of extracellular miRNAs in bovine follicular fluid and blood plasma and elucidate their mode of circulation and potential molecular mechanisms to be affected in the reproductive tract...
2015: Journal of Ovarian Research
https://www.readbyqxmd.com/read/26538853/endometrial-receptivity-array-clinical-application
#8
REVIEW
Nalini Mahajan
Human implantation is a complex process requiring synchrony between a healthy embryo and a functionally competent or receptive endometrium. Diagnosis of endometrial receptivity (ER) has posed a challenge and so far most available tests have been subjective and lack accuracy and a predictive value. Microarray technology has allowed identification of the transcriptomic signature of the window of receptivity window of implantation (WOI). This technology has led to the development of a molecular diagnostic tool, the ER array (ERA) for diagnosis of ER...
July 2015: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/26385059/is-endometrial-receptivity-transcriptomics-affected-in-women-with-endometriosis-a-pilot-study
#9
MULTICENTER STUDY
Juan A Garcia-Velasco, Amelie Fassbender, Maria Ruiz-Alonso, David Blesa, Thomas D'Hooghe, Carlos Simon
Endometrial receptivity is still questioned today in women with endometriosis. The aim of this study was to assess the endometrial receptivity gene signature in patients with different stages of endometriosis by investigating transcriptomic modifications of their endometrium using the endometrial receptivity array (ERA) test. A prospective, interventional multicentre pilot trial was designed and implemented in two university-affiliated infertility units from Belgium and Spain. Gene expression microarray was used to diagnose the receptivity status by quantifying the expression of 238 specific genes directly related to human endometrial receptivity...
November 2015: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/25827647/understanding-and-improving-endometrial-receptivity
#10
REVIEW
Jose A Miravet-Valenciano, Alejandro Rincon-Bertolin, Felipe Vilella, Carlos Simon
PURPOSE OF THE REVIEW: For a successful pregnancy, the synchronic coordination between the embryonic development and the endometrial status is crucial. The endometrium is a hormonally regulated organ that is nonadhesive to embryos throughout most of the menstrual cycle in humans. Endometrial receptivity refers to a hormone-limited period in which the endometrial tissue acquires a functional and transient ovarian steroid-dependent status allowing blastocyst implantation and therefore pregnancy initiation...
June 2015: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25818663/human-endometrial-transcriptomics-implications-for-embryonic-implantation
#11
REVIEW
Eva Gómez, Maria Ruíz-Alonso, Jose Miravet, Carlos Simón
Human endometrium has been extensively investigated in the search for markers capable of predicting its receptive status. The completion of the Human Genome Project has triggered a rapid development of new fields in molecular biology, the "transcriptomics" being a major turning point in the knowledge acquisition of endometrial receptivity. Based on this, a customized Endometrial Receptivity Array (ERA) has been developed, which is capable of identifying the genomic signature of receptivity. This diagnostic tool showed that the window of implantation (WOI) is displaced in one out of four patients with implantation failure, allowing the identification of their personalized WOI...
July 2015: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/25475586/chromosome-constitution-of-human-embryos-generated-after-in-vitro-maturation-including-3-isobutyl-1-methylxanthine-in-the-oocyte-collection-medium
#12
C Spits, L Guzman, A Mertzanidou, K Jacobs, C Ortega-Hrepich, R B Gilchrist, J G Thompson, M De Vos, J Smitz, K Sermon
STUDY QUESTION: Do cleavage-stage embryos obtained from oocytes matured in vitro after pre-incubation with a phosphodiesterase inhibitor (IBMX) carry more chromosomal abnormalities than those generated from oocytes matured in vivo? SUMMARY ANSWER: The rate and type of chromosomal abnormalities in normally developing cleavage-stage embryos generated with an in vitro maturation (IVM) system including pre-incubation with IBMX are not different from those observed in supernumerary embryos obtained from oocytes matured in vivo...
March 2015: Human Reproduction
https://www.readbyqxmd.com/read/25241377/timing-the-window-of-implantation-by%C3%A2-nucleolar-channel-system-prevalence-matches-the-accuracy-of%C3%A2-the-endometrial-receptivity-array
#13
RANDOMIZED CONTROLLED TRIAL
Edward J Nejat, Maria Ruiz-Alonso, Carlos Simón, U Thomas Meier
OBJECTIVE: To test if nucleolar channel system (NCS) prevalence matches the accuracy of the endometrial receptivity array (ERA) for identification of the window of endometrial receptivity. DESIGN: Comparative retrospective study, May 2008-May 2012. SETTING: University-affiliated infertility clinic. PATIENT(S): Forty-nine healthy oocyte donors, regularly cycling, aged 20-34 years with a body mass index of 19-25 kg/m2...
November 2014: Fertility and Sterility
https://www.readbyqxmd.com/read/25106620/deciphering-the-proteomic-signature-of-human-endometrial-receptivity
#14
Tamara Garrido-Gómez, Alicia Quiñonero, Oreto Antúnez, Patricia Díaz-Gimeno, Jose Bellver, Carlos Simón, Francisco Domínguez
STUDY QUESTION: Are there any proteomic differences between receptive (R) and non-receptive (NR) endometrial receptivity array (ERA)-diagnosed endometria obtained on the same day of a hormonal replacement therapy (HRT) treatment cycle? SUMMARY ANSWER: There is a different proteomic signature between R and NR ERA-diagnosed endometrium obtained on the same day of HRT cycles. WHAT IS KNOWN ALREADY: The human endometrial transcriptome has been extensively investigated in the last decade resulting in the development of a new diagnostic test based on the transcriptomic signature of the window of implantation (WOI)...
September 2014: Human Reproduction
https://www.readbyqxmd.com/read/25076120/epigenetic-regulation-of-uterine-biology-by-transcription-factor-klf11-via-posttranslational-histone-deacetylation-of-cytochrome-p450-metabolic-enzymes
#15
Ye Zheng, Zaid M Tabbaa, Zaraq Khan, John K Schoolmeester, Sherif El-Nashar, Abimbola Famuyide, Gary L Keeney, Gaurang S Daftary
Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is determined by adjusting their metabolic rate and fate via regulation of cytochrome (CYP) p450 enzymes. The CYP enzymes are targeted by ubiquitously expressed Sp/Krüppel-like (Sp/KLF) transcription factors...
November 2014: Endocrinology
https://www.readbyqxmd.com/read/25051170/minireview-steroid-regulated-paracrine-mechanisms-controlling-implantation
#16
REVIEW
Sandeep Pawar, Alison M Hantak, Indrani C Bagchi, Milan K Bagchi
Implantation is an essential process during establishment of pregnancy in mammals. It is initiated with the attachment of the blastocyst to a receptive uterine epithelium followed by its invasion into the stromal tissue. These events are profoundly regulated by the steroid hormones 17β-estradiol and progesterone. During the past several years, mouse models harboring conditional gene knockout mutations have become powerful tools for determining the functional roles of cellular factors involved in various aspects of implantation biology...
September 2014: Molecular Endocrinology
https://www.readbyqxmd.com/read/25023678/transcriptomics-of-the-human-endometrium
#17
REVIEW
Patricia Díaz-Gimeno, Maria Ruíz-Alonso, David Blesa, Carlos Simón
During the mid-secretory phase, the endometrium acquires the receptive phenotype, which corresponds to the only period throughout the endometrial cycle in which embryo implantation is viable. Endometrial receptivity is a crucial process and even more important in Assisted Reproductive Technologies (ART) where embryo-endometrial synchronization is coordinated through embryo transfer timing. Over the last decade, transcriptomic analyses performed on the human endometrium have shown that specific genomic signatures can be used to successfully phenotype different phases of the menstrual cycle including the receptive stage, independently of the histological appereance of the endometrial tissue...
2014: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/24959823/clinical-management-of-endometrial-receptivity
#18
REVIEW
David Blesa, María Ruiz-Alonso, Carlos Simón
The endometrial window of implantation (WOI), the cycle days during which normal embryo implantation can occur, has generally been assumed to begin on cycle day 19 or 20 of an idealized 28 days cycle and last for 4 to 5 days. Noyes et al took the first steps in defining the WOI by establishing a set of morphological criteria to evaluate endometrial development and receptivity, but recent studies have invalidated their use in the routine evaluation of infertility. Based on greater than 10 years of extensive research, our group has developed a molecular diagnostic tool (the endometrial receptivity array [ERA] test) based on the specific transcriptomic signature that identifies the receptive endometrium in natural and artificial (hormonal replacement therapy) cycles...
September 2014: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/24706003/the-impact-of-using-the-combined-oral-contraceptive-pill-for-cycle-scheduling-on-gene-expression-related-to-endometrial-receptivity
#19
Alfonso Bermejo, Carlos Iglesias, María Ruiz-Alonso, David Blesa, Carlos Simón, Antonio Pellicer, Juan García-Velasco
STUDY QUESTION: Does the combined oral contraceptive pill (COCP) change endometrial gene expression when used for cycle programming? SUMMARY ANSWER: COCP used for scheduling purposes does not have a significant impact on endometrial gene expression related to endometrial receptivity. WHAT IS KNOWN ALREADY: Controversy exists around COCP pretreatment for IVF cycle programming, as some authors claim that it might be detrimental to the live birth rate...
June 2014: Human Reproduction
https://www.readbyqxmd.com/read/24635108/recent-advances-in-understanding-endometrial-receptivity-molecular-basis-and-clinical-applications
#20
REVIEW
Carolina von Grothusen, Sujata Lalitkumar, Nageswara Rao Boggavarapu, Kristina Gemzell-Danielsson, Parameswaran G Lalitkumar
Advancement in the field of ART has lead to the possibility of achieving good quality embryos. However, the success rate in ART needs further improvement. This is largely dependent on identifying the receptive endometrium for the successful implantation of embryos as well as modulating the endometrium to the receptive stage. In the last half-a-decade, focus has been shifting toward identifying the receptive endometrium. Here, we summarize different tools explored to identify receptive endometrium from the literature, mainly focusing on the past decade, with the help of PubMed...
August 2014: American Journal of Reproductive Immunology: AJRI
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