Nilanjan Ganguly, Tapasi Das, Avishek Bhuniya, Ipsita Guha, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Saurav Bera, Jesmita Dhar, Shayani Dasgupta, Akata Saha, Tithi Ghosh, Juhina Das, Ugir Hossain Sk, Saptak Banerjee, Subrata Laskar, Anamika Bose, Rathindranath Baral
BACKGROUND: A water-soluble ingredient of mature leaves of the tropical mahogany 'Neem' (Azadirachta indica), was identified as glycoprotein, thus being named as 'Neem Leaf Glycoprotein' (NLGP). This non-toxic leaf-component regressed cancerous murine tumors (melanoma, carcinoma, sarcoma) recurrently in different experimental circumstances by boosting prime antitumor immune attributes. Such antitumor immunomodulation, aid cytotoxic T cell (Tc )-based annihilation of tumor cells. This study focused on identifying and characterizing the signaling gateway that initiate this systemic immunomodulation...
April 23, 2024: Cell Communication and Signaling: CCS