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JOURNAL ARTICLE
Pierre Pouvreau, Julien Coelho, Cécile Rumeau, Olivier Malard, Renaud Garrel, Justin Michel, Christian Righini, Sebastien Vergez, Robin Baudouin, Vianney Bastit, Jean-Paul Marie, Aude Villepelet, Antoine Moya-Plana, Pierre Philouze, Nicolas Saroul, Laurence Digue, Amaury Daste, Sophie Renard, Sylvain Moriniere, Florent Carsuzaa, Benjamin Verillaud, Gilles Poissonnet, Philippe Schultz, Esteban Brenet, François Mouawad, Juliette Thariat, Noémie Vulquin, Claire Castain, Ludovic de Gabory, Charles Dupin
OBJECTIVES: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive disease requiring multimodal treatment, and multiple new entities once included in the spectrum of SNUC, such as SWI/SNF-deficient carcinomas, are emerging. We aimed to provide new data regarding the role of chemotherapy and surgery and the prognostic factors of disease-free survival. METHODS: This study was based on data from the REFCOR database and included patients with SNUC treated with curative intent from 2007 to 2021 across 22 centres in France...
October 5, 2023: European Journal of Surgical Oncology
#22
REVIEW
Alicia Su Yun See, Clarisse Chu, Isis Claire Zhen Yu Lim, Benjamin Kye Jyn Tan, Sheryl Xiu Qi Ang, Shuhui Xu, Neville Wei Yang Teo, Tze Choong Charn
OBJECTIVES: Sinonasal undifferentiated carcinoma (SNUC) is a rare but aggressive tumour with very poor prognosis. There are currently no well-established clinical trials to guide therapy and the impact of various treatment modalities on survival is not well defined. We aim to provide an updated systematic review on current treatment modalities on survival outcomes. DESIGN AND SETTING: Individual patient data were extracted, and survival data pooled in a one-stage meta-analysis...
January 2024: Clinical Otolaryngology
#23
JOURNAL ARTICLE
Carl Korsström, Markus Lilja, Lalle Hammarstedt-Nordenvall, Antti Mäkitie, Aaro Haapaniemi
PURPOSE: The Nordic countries (27 M) all have comparable, publicly funded healthcare systems, and the management of sinonasal tumours is centralised to the 21 university hospitals. We sought to assess and compare the treatment practice of sinonasal tumours across the Nordic countries. METHODS: A web-based questionnaire was sent to all university hospital departments of otorhinolaryngology-head and neck surgery in the Nordic countries. RESULTS: Answers were obtained from all 21 Nordic university hospitals...
September 21, 2023: European Archives of Oto-rhino-laryngology
#24
JOURNAL ARTICLE
Zainab Waseem, Sajid Mushtaq, Usman Hassan, Mudassar Hussain, Asif Loya, Raza Hussain, Arif Jamshaid
OBJECTIVES: To analyse the clinicopathological characteristics of sinonasal malignancies in the light of the updates regarding head and neck tumours. METHODS: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data of patients diagnosed with primary malignant tumours of the sinonasal tract between 2015 and 2020. Slides related to biopsies and resection specimens were retrieved from the institutional database and reviewed by two pathologists...
August 2023: JPMA. the Journal of the Pakistan Medical Association
#25
REVIEW
Edward C Kuan, Eric W Wang, Nithin D Adappa, Daniel M Beswick, Nyall R London, Shirley Y Su, Marilene B Wang, Waleed M Abuzeid, Borislav Alexiev, Jeremiah A Alt, Paolo Antognoni, Michelle Alonso-Basanta, Pete S Batra, Mihir Bhayani, Diana Bell, Manuel Bernal-Sprekelsen, Christian S Betz, Jean-Yves Blay, Benjamin S Bleier, Juliana Bonilla-Velez, Claudio Callejas, Ricardo L Carrau, Roy R Casiano, Paolo Castelnuovo, Rakesh K Chandra, Vasileios Chatzinakis, Simon B Chen, Alexander G Chiu, Garret Choby, Naweed I Chowdhury, Martin J Citardi, Marc A Cohen, Roi Dagan, Gianluca Dalfino, Iacopo Dallan, Camila Soares Dassi, John de Almeida, Angelo P Dei Tos, John M DelGaudio, Charles S Ebert, Ivan H El-Sayed, Jean Anderson Eloy, James J Evans, Christina H Fang, Nyssa F Farrell, Marco Ferrari, Nancy Fischbein, Adam Folbe, Wytske J Fokkens, Meha G Fox, Valerie J Lund, Gary L Gallia, Paul A Gardner, Mathew Geltzeiler, Christos Georgalas, Anne E Getz, Satish Govindaraj, Stacey T Gray, Jessica W Grayson, Bradley A Gross, Jordon G Grube, Ruifeng Guo, Patrick K Ha, Ashleigh A Halderman, Ehab Y Hanna, Richard J Harvey, Stephen C Hernandez, Adam L Holtzman, Claire Hopkins, Zhigang Huang, Zhenxiao Huang, Ian M Humphreys, Peter H Hwang, Alfred M Iloreta, Masaru Ishii, Michael E Ivan, Aria Jafari, David W Kennedy, Mohemmed Khan, Adam J Kimple, Todd T Kingdom, Anna Knisely, Ying-Ju Kuo, Devyani Lal, Eric D Lamarre, Ming-Ying Lan, Hien Le, Matt Lechner, Nancy Y Lee, Jivianne K Lee, Victor H Lee, Corinna G Levine, Jin-Ching Lin, Derrick T Lin, Brian C Lobo, Tran Locke, Amber U Luong, Kelly R Magliocca, Svetomir N Markovic, Gesa Matnjani, Erin L McKean, Cem Meço, William M Mendenhall, Loren Michel, Shorook Na'ara, Piero Nicolai, Daniel W Nuss, Gurston G Nyquist, Gretchen M Oakley, Kazuhiro Omura, Richard R Orlandi, Nobuyoshi Otori, Peter Papagiannopoulos, Zara M Patel, David G Pfister, Jack Phan, Alkis J Psaltis, Mindy R Rabinowitz, Murugappan Ramanathan, Ryan Rimmer, Marc R Rosen, Olabisi Sanusi, Zoukaa B Sargi, Philippe Schafhausen, Rodney J Schlosser, Ahmad R Sedaghat, Brent A Senior, Raj Shrivastava, Raj Sindwani, Timothy L Smith, Kristine A Smith, Carl H Snyderman, C Arturo Solares, Satyan B Sreenath, Aldo Stamm, Katharina Stölzel, Baran Sumer, Pavol Surda, Bobby A Tajudeen, Lester D R Thompson, Brian D Thorp, Charles C L Tong, Raymond K Tsang, Justin H Turner, Mario Turri-Zanoni, Aaron M Udager, Thibaut van Zele, Kyle VanKoevering, Kevin C Welch, Sarah K Wise, Ian J Witterick, Tae-Bin Won, Stephanie N Wong, Bradford A Woodworth, Peter-John Wormald, William C Yao, Chien-Fu Yeh, Bing Zhou, James N Palmer
BACKGROUND: Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology-based topics spanning the field. METHODS: In accordance with prior International Consensus Statement on Allergy and Rhinology documents, ICSNT assigned each topic as an Evidence-Based Review with Recommendations, Evidence-Based Review, and Literature Review based on the level of evidence...
February 2024: International Forum of Allergy & Rhinology
#26
JOURNAL ARTICLE
Mounika Reddy Y, Sourabh Padmanabhan, Shobhan Babu A, Sai Swarna B, Nagaraju
Purpose: The main purpose of this study is to understand the characteristics and management of sinonasal small round blue cell tumors and also to emphasise the role of immunohistochemistry in their diagnosis and on the outcomes after endoscopic/open excision in these patients. Methods: This is a retrospective study conducted at a tertiary care referral centre in India which included 38 patients with sino nasal for a period of 5 years. All the patients were evaluated clinically and radiologically. All cases were confirmed diagnostically with histopathological examination and immunohistochemistry following surgical excision either by endoscopic or open approach...
September 2023: Indian Journal of Otolaryngology and Head and Neck Surgery
#27
REVIEW
A Agarwal, A A Bhatt, G Bathla, S Kanekar, N Soni, J Murray, K Vijay, P Vibhute, P H Rhyner
Sinonasal and skull base tumors are a heterogeneous group of neoplasms with considerable histologic variation and overlapping imaging features. In 2022, the World Health Organization updated the head and neck tumor classification, further emphasizing the importance of molecular data and genetic alterations in sinonasal neoplasms. The changes include the addition of new entities and discussion of emerging entities, as well as changes to the taxonomy and characterization of tumors. The new classification focuses on entities that develop in these sites either exclusively (eg, olfactory neuroblastoma) or most frequently...
October 2023: AJNR. American Journal of Neuroradiology
#28
REVIEW
Katie L Melder, Mathew Geltzeiler
Sinonasal squamous cell carcinoma (SNSCC) and sinonasal undifferentiated carcinoma (SNUC) are two of the most common, high-grade malignancies of the sinonasal cavity. The standard of care for resectable lesions per the National Comprehensive Cancer Network (NCCN) guidelines includes surgical resection with negative margins plus adjuvant radiation therapy. However, surgery for locally advanced disease with both orbital and intracranial involvement is associated with significant morbidity and poor overall survival...
July 26, 2023: Cancers
#29
JOURNAL ARTICLE
Juan B Laforga, Bacem Abdullah
The newly emerging sinonasal carcinomas have demonstrated diverse morphologies and specific molecular rearrangements along with deviant clinical behavior from conventional counterparts. We aim to propose a diagnostic algorithm that is based on molecular findings of each sinonasal cancer and is considering the new entities has been called upon. Such a diagnostic algorithm should help diagnostic pathologists establish a diagnosis of a challenging sinonasal blue cell carcinomas and researchers performing retrospective analysis of archival cases...
July 12, 2023: Pathology, Research and Practice
#30
JOURNAL ARTICLE
Anas M Qatanani, Jacob G Eide, Jacob C Harris, Jason A Brant, James N Palmer, Nithin D Adappa, Rijul S Kshirsagar
Background Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy with a poor prognosis, and multimodal therapy is the standard of care. We sought to characterize treatment delays in SNUC managed with surgery and adjuvant radiation and to determine the impact on survival using the National Cancer Database (NCDB). Methods This was a retrospective, population-based cohort study of patients with SNUC between 2004 and 2016 in the NCDB. The intervals of diagnosis to surgery (DTS), surgery to radiation (SRT), and radiation duration (RTD) were examined...
August 2023: Journal of Neurological Surgery. Part B, Skull Base
#31
Saswata Saha, Vijay M Patil, Vanita Noronha, Nandini Menon, Ajay Kumar Singh, Mannavi Suman, Amit Agrawal, Satvik Khaddar, Shatabdi Chakraborty, Prathamesh S Pai, Devendra A Chaukar, Pankaj Chaturvedi, Sarbani Ghosh Laskar, Kumar Prabhash
INTRODUCTION: Sinonasal carcinomas are a rare type of head and neck malignancy with various histologies. The outcomes of patients with unresectable locally advanced sinonasal carcinomas are poor. Hence, we performed this analysis to study the long-term outcomes of sinonasal adenocarcinoma (SNAC) and sinonasal undifferentiated carcinomas (SNUC) where neoadjuvant chemotherapy (NACT) has been given followed by local therapy. METHODS: 16 patients with SNUC and adenocarcinoma who received NACT were found eligible for the study...
2023: Ecancermedicalscience
#32
REVIEW
Abbas Agaimy
The pathology of poorly differentiated sinonasal malignancies has undergone a dynamic evolution during the last decade, resulting in a refined, mostly genetically or etiologically oriented classification of neoplasms in the historical spectrum of sinonasal undifferentiated carcinoma (NUT carcinoma, SWI-/SNF-deficient carcinomas, and others). Moreover, some new entities have been established, while others could be further delineated and better characterized. A highlight of the new classification is the inclusion of SWI/SNF (SMARCB1 or SMARCA4)-deficient carcinomas into a separate category...
July 2023: Pathologie (Heidelb)
#33
REVIEW
Lisa M Rooper
Although the definitions of sinonasal neuroendocrine and neuroectodermal neoplasms did not change substantially in the 5th edition WHO Classification of Head and Neck Tumours, the diagnosis of olfactory neuroblastoma (ONB), small cell neuroendocrine carcinoma, and large cell neuroendocrine carcinoma remains quite challenging in practice. Ambiguities surrounding the amount of keratin expression allowable in ONB and the amount of neuroendocrine differentiation seen in sinonasal undifferentiated carcinoma (SNUC) lead to significant diagnostic discrepancies at the high grade end of this tumor spectrum...
May 15, 2023: Head and Neck Pathology
#34
JOURNAL ARTICLE
Emilien Chabrillac, Caroline Even, Valérie Costes-Martineau, Nicolas Fakhry, Laurence Digue, Antoine Moya-Plana, Bertrand Baujat, Christian-Adrien Righini, Ludovic De Gabory, Benjamin Verillaud, Sébastien Vergez, Juliette Thariat
Among the 16,000 new cases of malignant tumors of the head and neck diagnosed in France each year, 10% are not conventional squamous cell carcinomas. These so-called rare cancers are distinguished by their presentation and patterns of failure, which is important to recognize in order to offer specific adapted management and maximize the chances of tumor control. These cancers can be rare by their histology, which determines their local invasiveness, and their hematogenous/nodal spread. Their diagnosis can be difficult and often requires comprehensive immunohistochemistry and genomic techniques...
May 9, 2023: Bulletin du Cancer
#35
JOURNAL ARTICLE
Houda Bahig, Hanna Y Ehab, Adam S Garden, Sweet Ping Ng, Steven J Frank, Theresa Nguyen, Gary B Gunn, David I Rosenthal, Clifton D Fuller, Renata Ferrarotto, Diana Bell, Shirley Su, Jack Phan
PURPOSE: To report long-term outcomes of modern radiotherapy for sinonasal cancers. METHODS AND MATERIALS: A retrospective analysis of patients with sinonasal tumors treated with intensity-modulated radiotherapy or proton therapy. Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS). RESULTS: Three hundred and eleven patients were included, with median follow-up of 75 months...
July 2023: Head & Neck
#36
MULTICENTER STUDY
Carlo Resteghini, Paolo Castelnuovo, Piero Nicolai, Ester Orlandi, Paolo Bossi, Barbara Vischioni, Alberto Schreiber, Simone Gambazza, Nicola Alessandro Iacovelli, Paolo Battaglia, Marco Guzzo, Mario Turri-Zanoni, Davide Mattavelli, Nadia Facchinetti, Giuseppina Calareso, Marco Ravanelli, Carla Facco, Tiziana Tartaro, Lisa Licitra
PURPOSE: Sinonasal tumours are rare diseases with poor prognosis. Multimodal approach including surgery is widely used, although no standard therapy has been established in prospective trials. This study assessed activity and safety of an innovative integration of multimodality treatment-induction chemotherapy (ICT), surgery and radiotherapy (RT)-modulated by histology and response to ICT. METHODS: Patients with untreated, operable sinonasal tumours with selected histotypes (squamous cell carcinoma, intestinal-type adenocarcinoma, sinonasal undifferentiated and neuroendocrine carcinoma, olfactory neuroblastoma) were enrolled in a single-arm, phase II, multicenter clinical trial...
July 2023: European Journal of Cancer
#37
JOURNAL ARTICLE
Paolo Bossi, Ester Orlandi, Carlo Resteghini, Barbara Vischioni, Piero Nicolai, Paolo Castelnuovo, Simone Gambazza, Laura D Locati, Mario Turri-Zanoni, Marco Ferrari, Nadia Facchinetti, Nicola A Iacovelli, Giuseppina Calareso, Pasquale Quattrone, Anna Cavallo, Alessandro Tuzi, Lisa Licitra
PURPOSE: Unresectable, locally advanced sinonasal epithelial tumours are rare diseases with poor prognosis. Multimodal approach is widely used, although no standard therapy has been established in prospective trials. This study assessed activity and safety of an innovative integration of multimodality treatment-induction chemotherapy (ICT), surgery and radiotherapy (RT)-modulated by histology and response to ICT. METHODS: Patients with untreated, unresectable sinonasal epithelial tumours with selected histotypes (squamous cell carcinoma, intestinal-type adenocarcinoma, sinonasal undifferentiated and neuroendocrine carcinoma, olfactory neuroblastoma) were enroled in a single-arm, open-label, phase II, multicentre clinical trial...
April 7, 2023: European Journal of Cancer
#38
JOURNAL ARTICLE
Martin Wartenberg, Sara-Lynn Hool, Andrea Marrazzini, Roland Giger, Niels J Rupp
BACKGROUND: In recent years, the list of tumor entities in the sinonasal tract has significantly expanded, requiring advanced diagnostic testing. We report the case of a 32-year-old patient with an unusual NUT carcinoma originating in the maxillary sinus, which showed extensive well-differentiated, papillary squamous morphology, similar to the spectrum of the recently described DEK::AFF2 fusion-associated carcinoma. METHODS: We performed immunohistochemical and molecular studies including EBV- and HPV-testing, as well as DNA/RNA next generation sequencing...
April 28, 2023: Head and Neck Pathology
#39
JOURNAL ARTICLE
Barbara Vischioni, Rossana Ingargiola, Maria Bonora, Sara Ronchi, Anna Maria Camarda, Stefania Russo, Eleonora Rossi, Giuseppe Magro, Alfredo Mirandola, Ester Orlandi
Sinonasal cancers (SNCs) are rare and heterogeneous in histology and biological behavior. The prognosis is generally unfavorable, especially in inoperable cases. In recent years, for some histologies, such as undifferentiated sinonasal carcinoma (SNUC), multimodal treatment with a combination of induction chemotherapy, surgery, and chemo/radiotherapy (RT) has improved the prognosis. Nevertheless, still about half of the patients treated incur a recurrence, in most of the cases at the local site. Surgery with and without RT is usually the treatment choice in cases of recurrence after previous RT in combination with systemic therapy or RT in a histology-driven fashion...
March 31, 2023: Journal of Clinical Medicine
#40
JOURNAL ARTICLE
Sarah C Nyirjesy, Rachel Fenberg, Margaret A Heller, Ryan T Judd, Michael M Li, Brandon Koch, Marcelo Bonomi, Ricardo L Carrau, Kyle K VanKoevering
BACKGROUND: Sinonasal malignancy (SNM) is a heterogeneous group of diseases for which induction chemotherapy (IC) may reduce tumor burden. The purpose of this study was to characterize the response to IC in SNM as a prognostic factor through its effect on survival. METHODS: Retrospective cohort of patients undergoing IC for SNM between 2010 and 2019 at our quaternary referral center. RESULTS: Forty-two patients with advanced SNM were included in the analysis...
June 2023: Head & Neck
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