keyword
MENU ▼
Read by QxMD icon Read
search

SNUC

keyword
https://www.readbyqxmd.com/read/27857871/sinonasal-carcinomas-with-neuroendocrine-features-histopathological-differentiation-and-treatment-outcomes
#1
Liuba Soldatova, Raewyn G Campbell, Ricardo L Carrau, Daniel M Prevedello, Paul Wakely, Bradley A Otto, Leo F Ditzel Filho
Objectives Sinonasal cancers with neuroendocrine features share similar clinical, radiological, and histopathological features; however, these tumors often exhibit varying degrees of aggressive behavior presenting significant treatment challenges. The objective of this study was to report our experience with these rare malignancies and to present a review of current literature. Methods Following institutional review board approval, the records of all patients with biopsy-proven sinonasal malignancies over a 5-year period were reviewed...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27717204/treatment-modalities-in-sinonasal-undifferentiated-carcinoma-an-analysis-from-the-national-cancer-database
#2
Mohemmed N Khan, Neeraja Konuthula, Arjun Parasher, Eric M Genden, Brett A Miles, Satish Govindaraj, Alfred M Iloreta
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy of unknown etiology with a poor overall prognosis. Its relative rarity has made it difficult to determine the impact of different treatment modalities on survival. METHODS: Retrospective study of cases in the National Cancer Data Base (NCDB). NCDB cases that were diagnosed as having SNUC between January 1, 2004, and December 31, 2013 were included in the analysis. Outcomes of patients treated with surgery followed adjuvant chemoradiotherapy were compared with definitive chemoradiotherapy...
October 7, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27703092/survival-outcomes-for-combined-modality-therapy-for-sinonasal-undifferentiated-carcinoma
#3
Phoebe Kuo, R Peter Manes, Zachary G Schwam, Benjamin L Judson
OBJECTIVE: Sinonasal undifferentiated carcinoma is a rare and aggressive malignancy of the nasal cavity and paranasal sinuses. Multi-institutional studies examining outcomes of combined modality treatment versus other treatment modalities have not been performed. The objective of our study was to present outcomes for multimodality therapy through use of the National Cancer Database. STUDY DESIGN: Retrospective cohort study. SETTING: National Cancer Database...
October 4, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27644951/ini1-smarcb1-deficient-sinonasal-carcinoma-a-clinicopathologic-report-of-2-cases
#4
Jason K Wasserman, Brendan C Dickson, Bayardo Perez-Ordonez, John R de Almeida, Jonathan C Irish, Ilan Weinreb
Poorly differentiated sinonasal malignancies are amongst the hardest differential diagnoses in pathology, owing to the large number of rare entities that arise there. Complicating the matter is that most pathologists, including those with experience in head and neck pathology, have little experience in any one of these rare entities. Most patients with sinonasal carcinoma present with locally advanced disease and in the past a combination of chemotherapy, radiotherapy, and surgery would usually be recommended without the specific disease subtype playing a large part of the decision making...
September 19, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27576899/relationship-between-18-fdg-pet-and-different-types-of-sinonasal-malignancies
#5
Marylisa Felix-Ravelo, Ayoub Bey, Fabien Arous, Solène Paris-Grandpierre, Roger Jankowski, Duc Trung Nguyen
CONCLUSION: The sensitivity and specificity of a (18)FDG-PET scan may be different according to the histology. The SUVmax and SUV ratio may reflect the tumor's aggressive behavior. OBJECTIVES: To describe the characteristics of PET/CT scans, including the maximum standard uptake values (SUVmax), at initial diagnosis according to six main types of sinonasal malignancies: sinonasal adenocarcinoma (SNAC), sinonasal undifferentiated carcinoma (SNUC), adenoid cystic carcinoma (ACC), sinonasal malignant melanoma (SMM), olfactory neuroblastoma (ONB), and sinonasal neuroendocrine carcinoma (SNEC)...
August 31, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27526015/poorly-differentiated-sinonasal-tract-malignancies-a-review-focusing-on-recently-described-entities
#6
Abbas Agaimy
Sinonasal tract malignancies are uncommon, representing no more than 5% of all head and neck neoplasms. However, in contrast to other head and neck sites, a significant proportion of sinonasal neoplasms tend to display a poorly/ undifferentiated significantly overlapping morphology and a highly aggressive clinical course, despite being of diverse histogenetic and molecular pathogenesis. The wide spectrum of poorly differentiated sinonasal epithelial neoplasms with small "basaloid" blue cell morphology includes basaloid squamous cell carcinoma (both HPV+ and HPV-unrelated), nasopharyngeal-type lymphoepithelial carcinoma (EBV+), small/large cell neuroendocrine carcinoma, esthesioneuroblastoma, poorly differentiated carcinoma of salivary type (myoepithelial carcinoma and solid adenoid cystic carcinoma), NUT midline carcinoma, the recently described SMARCB1-deficient sinonasal carcinoma, sinonasal teratocarcinosarcoma and, as a diagnosis of exclusion, sinonasal undifferentiated carcinoma (SNUC)...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27478703/human-population-and-socioeconomic-modulators-of-conservation-performance-in-788-amazonian-and-atlantic-forest-reserves
#7
Ana Alice B de Marques, Mauricio Schneider, Carlos A Peres
Protected areas form a quintessential component of the global strategy to perpetuate tropical biodiversity within relatively undisturbed wildlands, but they are becoming increasingly isolated by rapid agricultural encroachment. Here we consider a network of 788 forest protected areas (PAs) in the world's largest tropical country to examine the degree to which they remain intact, and their responses to multiple biophysical and socioeconomic variables potentially affecting natural habitat loss under varying contexts of rural development...
2016: PeerJ
https://www.readbyqxmd.com/read/27471252/div-seq-single-nucleus-rna-seq-reveals-dynamics-of-rare-adult-newborn-neurons
#8
Naomi Habib, Yinqing Li, Matthias Heidenreich, Lukasz Swiech, Inbal Avraham-Davidi, John J Trombetta, Cynthia Hession, Feng Zhang, Aviv Regev
Single-cell RNA sequencing (RNA-Seq) provides rich information about cell types and states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation of rare neurons from adult tissue is challenging and markers for each phase are limited. Here, we develop Div-Seq, which combines scalable single-nucleus RNA-Seq (sNuc-Seq) with pulse labeling of proliferating cells by 5-ethynyl-2'-deoxyuridine (EdU) to profile individual dividing cells. sNuc-Seq and Div-Seq can sensitively identify closely related hippocampal cell types and track transcriptional dynamics of newborn neurons within the adult hippocampal neurogenic niche, respectively...
August 26, 2016: Science
https://www.readbyqxmd.com/read/26954865/pre-operative-chemoradiation-for-sinonasal-undifferentiated-carcinoma-of-the-anterior-nasal-cavity-resected-through-a-lateral-nasal-flap-approach
#9
Bhavishya Surapaneni, Sameep Kadakia, Oleh Slupchynskyj, Codrin Iacob, Roy Holliday
INTRODUCTION: Sinonasal undifferentiated carcinoma (SNUC) is an exceedingly rare and aggressive tumor that carries a poor prognosis due to its non-specific presentation and advanced stage at time of diagnosis. Early detection and treatment are vital, with chemotherapy, radiation, and surgery all being viable options. The literature is sparse and there is no consensus for optimal treatment. In surgical candidates, the otolaryngologist must have a vast skill set in order to resect the tumor with wide margins and reconstruct the defect in hopes of returning the patient to their pre-morbid state...
March 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/26908559/significance-of-tumor-stage-in-sinonasal-undifferentiated-carcinoma-survival-a-population-based-analysis
#10
Edward C Kuan, Armin Arshi, Jon Mallen-St Clair, Bobby A Tajudeen, Elliot Abemayor, Maie A St John
OBJECTIVE: To describe the incidence and determinants of survival of patients with sinonasal undifferentiated carcinoma (SNUC) from 1973 to 2011 using the SEER database (Surveillance, Epidemiology, and End Results), with consideration of tumor stage based on the Kadish system. STUDY DESIGN: Retrospective database analysis. SETTING: Academic medical center. SUBJECTS AND METHODS: The SEER registry was utilized to calculate survival trends for 328 patients with SNUC between 1973 and 2011...
April 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/26829682/management-of-sinonasal-undifferentiated-carcinoma-with-intracerebral-invasion-clinical-experience-at-a-single-institution-and-review-of-the-literature
#11
Valerie Zielinski, Simon Laban, Silke Tribius, Phillipe Schafhausen, Simon Veldhoen, Rainald Knecht, Till Clauditz, Adrian Muenscher
Sinonasal undifferentiated carcinoma (SNUC) represents less than 1% of all malignancies. Most of the tumors are diagnosed at an advanced stage, when they have already invaded neighboring tissue structures. We describe the cases of 2 patients with a substantial intracerebral extension of SNUC who were treated at our institution. One was treated with surgery followed by chemoradiotherapy. The other was primarily treated with induction chemotherapy with a combination of docetaxel, cisplatin, and 5-fluorouracil followed by concurrent chemo- and radiotherapy...
January 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/26559439/nodal-metastasis-and-elective-nodal-level-treatment-in-sinonasal-small-cell-and-sinonasal-undifferentiated-carcinoma-a-surveillance-epidemiology-and-end-results-analysis
#12
Peter H Ahn, Nandita Mitra, Michelle Alonso-Basanta, Nithin D Adappa, James N Palmer, Bert W O'Malley, Christopher H Rassekh, Ara Chalian, Roger B Cohen, Alexander Lin
OBJECTIVE: Risk of nodal involvement in patients with sinonasal small-cell carcinoma and sinonasal undifferentiated carcinoma (SNUC) has not been well defined because of their rarity. We describe a population-based assessment of specific nodal level involvement in this group of rare neuroectodermal tumours. METHODS: The Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2011 identified patients with SNUC and sinonasal small-cell carcinoma. Overall neck involvement and individual nodal level involvement at presentation were assessed, and comparison was made with a contemporaneous cohort of patients with a borderline clinically significant risk of nodal involvement and recurrence...
2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26363162/current-management-of-sinonasal-undifferentiated-carcinoma
#13
Fernando Lopez, Vanessa Suárez, Blanca Vivanco, Carlos Suárez, José L Llorente
BACKGROUND: The management of sinonasal undifferentiated carcinoma (SNUC) remains unclear. Low incidence and poor outcomes make treatment standardization difficult. The objective of this study was to review the used treatment and our outcomes. METHODS: From 2001 to 2013, 17 cases of SNUC were treated at our department. Charts were reviewed for standard demographic, tumour size and extension, histological features, treatment strategies, surgical approach, adjuvant therapies, outcomes and complications...
September 2015: Rhinology
https://www.readbyqxmd.com/read/25923276/sinonasal-undifferentiated-carcinoma-as-a-third-primary-neoplasm-a-case-report-and-review-of-the-literature
#14
John J Chi, Michael D Feldman, James N Palmer
A 71-year-old man with a history of a pituitary prolactinoma and metastatic pancreatic carcinoma presented with epistaxis, visual changes, bilateral ophthalmoplegia, involuntary closure of the left eye, and ptosis of the right eye. The patient was found to have a soft-tissue mass in the posterior nasal cavity with extension through the floor of the sella turcica, the sphenoid sinuses, cavernous sinuses, and suprasellar region. The patient was subsequently taken to the operating room. Intraoperative frozen section of the sinonasal mass demonstrated carcinoma...
April 2015: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/25844294/incidence-and-survival-patterns-of-sinonasal-undifferentiated-carcinoma-in-the-united-states
#15
Kyle J Chambers, Ashton E Lehmann, Aaron Remenschneider, Matthew Dedmon, Josh Meier, Stacey T Gray, Derrick T Lin
Objective To determine trends in sinonasal undifferentiated carcinoma (SNUC) survival patterns in the United States. Design Retrospective review of national database. Participants All cases of SNUC in the National Cancer Institute's Surveillance Epidemiology and End Results program from 1973 to 2010 were examined. Main Outcome Measures Age-adjusted incidence and survival rates were calculated and stratified by demographic information and treatment modality. Cohort analysis was performed to analyze survival patterns over time...
March 2015: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/25804344/lymphoepithelial-like-carcinomas-of-the-head-and-neck
#16
REVIEW
Bruce M Wenig
Lymphoepithelial-like carcinomas (LELC) of the head and neck represent malignant neoplasms that are histologically similar to nasopharyngeal carcinoma (NPC), nonkeratinizing undifferentiated type but arise in locations other than the nasopharynx. The most common location for LELC in the head and neck is the salivary glands, in particular the parotid gland. However, LELC may arise in other sites including the oropharynx (tonsils, base of tongue), sinonasal tract, larynx, and middle ear/temporal bone. Unlike the nonkeratinizing undifferentiated type of NPC which is etiologically linked to Epstein-Barr virus (EBV), LELCs are not uniformly associated with EBV...
January 2015: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/25017972/role-of-p40-and-cytokeratin-5-6-in-the-differential-diagnosis-of-sinonasal-undifferentiated-carcinoma
#17
Lavleen Singh, Richa Ranjan, Sudheer Arava, M K Singh
Sinonasal undifferentiated carcinoma (SNUC) is an epithelial neoplasm of sinonasal region which does not exhibit a squamous or glandular differentiation. The challenge in diagnosis of this entity is the rarity of the disease, the varying morphology of the tumor which leads to gamut of differential diagnosis and the paucity of consistent immunohistochemical markers except pancytokeratin. Forty-one cases of sinonasal epithelial neoplasm consisting of 11 cases of SNUC and 10 cases each of high-grade (grade 3 and 4) esthesioneuroblastoma, undifferentiated nasopharyngeal carcinoma, and poorly differentiated squamous cell carcinoma of the sinonasal region were analyzed for morphology and immunoexpression of CK5/6 and p40...
October 2014: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/24421248/treatment-outcomes-and-prognostic-factors-including-human-papillomavirus-for-sinonasal-undifferentiated-carcinoma-a-retrospective-review
#18
Stacey T Gray, Marc W Herr, Rosh K V Sethi, Gillian Diercks, Linda Lee, William Curry, Annie Chan, John Clark, Eric H Holbrook, James Rocco, Peter M Sadow, Derrick T Lin
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a high-grade, aggressive neoplasm. Low incidence and poor outcomes make identification of prognostic factors and treatment standardization difficult. Similarly, little is known regarding the association of human papillomavirus (HPV) with SNUC. METHODS: A retrospective review was conducted. Extracted information included treatment received, tumor recurrence, patient survival, p16 expression, and HPV status...
March 2015: Head & Neck
https://www.readbyqxmd.com/read/24349741/the-small-round-blue-cell-tumors-of-the-sinonasal-area-histological-and-immunohistochemical-findings
#19
Mohammad J Ashraf, Leila Beigomi, Negar Azarpira, Bita Geramizadeh, Bijan Khademi, Afsoon Hakimzadeh, Elham Abedi
BACKGROUND: Primary Small round blue cell tumors (SRBCT) in sinonasal comprise histogenetically diverse entities with overlapping morphologic features. Because of the limited initial biopsy tissue materials, differential diagnostic difficulties may arise, and as they have different management, exact diagnosis and classification are very important. OBJECTIVES: In this study, we analyzed the immunohistochemical expression of a panel of markers in the classification and diagnosis of sinonasal SRBCTs...
June 2013: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/24268566/radiotherapy-for-sinonasal-undifferentiated-carcinoma
#20
MULTICENTER STUDY
Kaitlin Christopherson, John W Werning, Robert S Malyapa, Christopher G Morris, William M Mendenhall
PURPOSE: To evaluate the long-term effectiveness of radiotherapy (RT) in the treatment of sinonasal undifferentiated carcinoma (SNUC). MATERIALS AND METHODS: The medical records of 23 patients treated with definitive or postoperative RT between 1992 and 2010 at the University of Florida were retrospectively reviewed. Fifteen patients (65%) received primary surgery and postoperative RT. Radiation doses ranged from 59.0 to 74.8 Gy (median, 70.2 Gy). The median follow-up time for all patients was 3...
March 2014: American Journal of Otolaryngology
keyword
keyword
87047
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"