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https://www.readbyqxmd.com/read/29445997/human-papillomavirus-related-multiphenotypic-sinonasal-carcinoma-a-case-report-documenting-the-potential-for-very-late-tumor-recurrence
#1
Akeesha A Shah, Eric D Lamarre, Justin A Bishop
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior...
February 14, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29444558/limitations-of-the-endoscopic-endonasal-transcribriform-approach
#2
Neil Majmundar, Naveed Kamal, Renuka Reddy, Jean A Eloy, James K Liu
The endoscopic endonasal transcribriform approach (EETA) has become a useful strategy in the treatment of various anterior skull base pathology, including meningoencephaloceles, olfactory groove meningiomas, schwannomas, esthesioneuroblastomas, and other sinonasal malignancies. However, not all pathologies are optimally treated through this approach due to tumor size, extent of the lesion, vascular involvement, and the presence of intact olfaction. One must be prepared to use a transcranial approach if the EETA is not favorable...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29443431/sarcomas-of-the-sinonasal-tract
#3
Martin Kauke, Ali-Farid Safi, Andrea Grandoch, Hans-Joachim Nickenig, Joachim Zöller, Matthias Kreppel
BACKGROUND: Sinonasal sarcomas are rare and heterogeneous in nature. Continuously collecting data influencing the prognosis is fundamental for optimizing therapeutic assessment of this highly destructive neoplasm. METHODS: We conducted a single-institution retrospective cohort study considering 27 patients with sinonasal sarcoma. RESULTS: The overall survival (OS) rates for 1 year and 5 years were calculated as 74% and 36%, respectively. Extent of the primary tumor (P = ...
February 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29438167/insm1-is-a-sensitive-and-specific-marker-of-neuroendocrine-differentiation-in-head-and-neck-tumors
#4
Lisa M Rooper, Justin A Bishop, William H Westra
The head and neck is the site of a wide and sometimes bewildering array of neuroendocrine (NE) tumors. Although recognition of NE differentiation may be necessary for appropriate tumor classification and treatment, traditional NE markers such as synaptophysin, chromogranin, and CD56 are not always sufficiently sensitive or specific to make this distinction. Insulinoma-associated protein 1 (INSM1) is a novel transcription factor that has recently demonstrated excellent sensitivity and specificity for NE differentiation in various anatomic sites, but has not yet been extensively evaluated in tumors of the head and neck...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29430328/-invasive-sinonasal-papilloma-with-intracranial-invasion-case-report-and-bibliographic-review
#5
Andrés Di Pietrantonio, Humberto Asmus, Christian Ingratta, Walter Brennan, Javier Schulz, Leandro Carballo
Introduction: Inverted papilloma is a locally-aggressive benign neoplasm of the paranasal sinuses with a high potential for recurrence and malignancy. Intracranial extension is infrequent, and dural penetration even more so, typically associated with recurrence of the disease or its degeneration into squamous cell carcinoma. Clinical Case: A 32-year-old female patient consulted us for an exophytic lesion in her right nostril and exophthalmos, associated with headache, anosmia and dysgeusia...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29427030/sinonasal-neuroendocrine-neoplasms-current-challenges-and-advances-in-diagnosis-and-treatment-with-a-focus-on-olfactory-neuroblastoma
#6
Diana Bell
Sinonasal tumors with neuroendocrine differentiation form a group of rare heterogeneous neoplasms of neuroectodermal and epithelial origin, consisting of olfactory neuroblastomas and neuroendocrine carcinomas. Because the natural history and biological behavior of this group of tumors vary, the morphological diagnosis coupled with grading/staging is important for prognostication, and the approach to treatment and rehabilitation is multidisciplinary. The identification of molecular abnormalities underlying these tumors is critical to the development of specific targeted therapies and the design of clinical trials...
February 9, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29420383/primitive-squamous-cell-carcinoma-of-pterygopalatine-fossa
#7
Olivier Mauvais, Cécile Badet, Laetitia Lestrade, Laurent Tavernier
Primitive tumors of pterygopalatine fossa (PPF) are often benign tumors or extension of a malignant sinonasal tract. Primitive tumors may rarely occur in PPF.The authors present a 71-year-old woman with a 6-month history of left cranial nerve palsy. Magnetic resonance imaging and positron emission tomography-computed tomography showed an enhancing isolated lesion at the PPF. A transmaxillary biopsy was performed, leading to diagnosis of primitive squamous cell carcinoma. The patient underwent radiotherapy treatment...
February 7, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29416348/synovial-sarcoma-of-the-maxillary-sinus-an-extremely-rare-case-with-excellent-response-to-chemotherapy
#8
Shin Saito, Hiroyuki Ozawa, Yuuichi Ikari, Nana Nakahara, Fumihiro Ito, Mariko Sekimizu, Junichi Fukada, Kaori Kameyama, Kaoru Ogawa
This paper presents an extremely rare case of synovial sarcoma arising from the maxillary sinus, which resulted in a clinically complete response to chemotherapy. Synovial sarcoma is a rare soft tissue malignant tumor, most commonly affecting the extremities. While ~10% occur in the head and neck region, synovial sarcoma of the sinonasal tract is extremely rare, with only 11 cases having been reported previously. As with other sarcomas, the standard treatment is complete resection while allowing for a safe margin, but this is often difficult in the head and neck area due to the complicated anatomy there...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29414499/antrochoanal-polyp-concomitant-with-turbinoethmoidal-osteoma-a-case-report
#9
Yong Won Lee, Yong Min Kim
INTRODUCTION: Antrochoanal polyps (ACPs) have several unique features that distinguish them from other nasal polyps. Despite many investigations, the pathogenesis of ACP has not yet been elucidated. Sinonasal osteoma is the most common type of tumor of the sinonasal tract and can be caused by trauma, infection and developmental anomaly. PRESENTATION OF CASE: We report the case of a 35-year-old man with left nasal obstruction for more than 20 years. Examination revealed ACP concomitant with an osteoma that arose from the middle turbinate and ethmoid sinus...
January 28, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29410768/recurrence-in-a-patient-with-a-10-year-history-of-sinonasal-mucosal-melanoma-manifesting-as-facial-swelling
#10
Eleni-Marina Kalogirou, Demos Kalyvas, Konstantinos I Tosios, Kostas Tsiklakis, Alexandra Sklavounou
Sinonasal mucosal melanoma is a rare tumor that develops slowly and may manifest with non specific signs and symptoms, causing significant delay in diagnosis. Local recurrence is common and usually occurs within the first two years after the initial treatment. Prognosis of recurrent lesions is poor and 5-year survival ranges between 10-47%. We report the clinical, radiographic, histopathological and immunohistochemical findings of a recurrent sinonasal mucosal melanoma which was diagnosed 10 years after the initial treatment, in a patient who presented with unilateral facial swelling and one-sided difficulty in breathing of two years duration...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29408781/extradural-petromastoid-calcifying-pseudoneoplasm-of-the-neuraxis-capnon-case-report-and-literature-review
#11
Eric S Nussbaum, Chris Hilton, Archie Defillo, William McDonald, Theodore Passe, Kevin M Kallmes, Leslie A Nussbaum
BACKGROUND: Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a very rare tumor with fewer than 70 cases reported in the literature. In general, this tumor occurs intracranially either within the brain parenchyma or in an extra-axial location, but it has also been described within the spine as an extra-axial lesion. CASE DESCRIPTION: We describe an unusual case of intracranial-extradural CAPNON involving the mastoid region. This may be only the second such case reported in the literature, as one patient with CAPNON has been reported involving the sinonasal region...
January 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29404235/developmental-considerations-in-pediatric-skull-base-surgery
#12
REVIEW
Melissa A LoPresti, Jonathan N Sellin, Franco DeMonte
Objectives  To review developmental surgical anatomy and technical nuances related to pediatric skull base surgery. Design  Retrospective, single-center case series with literature review. Setting  MD Anderson Cancer Center. Participants  Patients undergoing pediatric skull base surgery. Main Outcome Measures  Review developmental anatomy of the pediatric skull base as it relates to technical nuance of various surgical approaches and insight gained from a 25-year institutional experience with this unique patient population...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29402308/cavernous-sinus-involvement-is-not-a-risk-factor-for-the-primary-tumor-site-treatment-outcome-of-sinonasal-adenoid-cystic-carcinoma
#13
Yi-Chan Lee, Ta-Jen Lee, Ngan-Ming Tsang, Yenlin Huang, Cheng-Lung Hsu, Li-Jen Hsin, Yi-Hsuan Lee, Kai-Ping Chang
BACKGROUND: Sinonasal adenoid cystic carcinoma is a rare malignancy of the head and neck. Cavernous sinus invasion from sinonasal adenoid cystic carcinoma and its related management have rarely been investigated. This study evaluated the relationship between treatment outcome and cavernous sinus involvement in addition to other parameters. METHODS: A retrospective case series study was conducted at a tertiary referral center. The medical records of 47 patients diagnosed with primary sinonasal adenoid cystic carcinoma between 1984 and 2015 were retrospectively reviewed...
February 5, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29396607/-sinonasal-tumors-news-from-the-who-with-special-reference-to-mesenchymal-entities
#14
REVIEW
A Agaimy, F Haller, A Hartmann
The last two decades have seen significant advances in the pathology of sinonasal tract neoplasms. This was the consequence of the availability of several innovative diagnostic tools, which resulted in a dynamic evolution of entities and splitting of newly defined or conceptualized entities and subtypes that have been included in the spectrum of old heterogeneous diseases. Most of these new tumor subtypes have distinctive demographic, clinicopathologic, and biological characteristics with prognostic and therapeutic implications for individual patients...
February 2, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29393751/endoscopic-anterior-transmaxillary-transalisphenoid-approach-to-meckel-s-cave-and-the-middle-cranial-fossa-an-anatomical-study-and-clinical-application
#15
Huy Q Truong, Xicai Sun, Emrah Celtikci, Hamid Borghei-Razavi, Eric W Wang, Carl H Snyderman, Paul A Gardner, Juan C Fernandez-Miranda
OBJECTIVE Multiple approaches have been designed to reach the medial middle fossa (for lesions in Meckel's cave, in particular), but an anterior approach through the greater wing of the sphenoid (transalisphenoid) has not been explored. In this study, the authors sought to assess the feasibility of and define the anatomical landmarks for an endoscopic anterior transmaxillary transalisphenoid (EATT) approach to Meckel's cave and the middle cranial fossa. METHODS Endoscopic dissection was performed on 5 cadaver heads injected intravascularly with colored silicone bilaterally to develop the approach and define surgical landmarks...
February 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29392404/-neuroendocrine-neoplasms-of-the-auditory-olfactory-and-visual-sensory-organs
#16
REVIEW
B Sipos
Neuroendocrine neoplasms (NENs) are infrequent in sensory organs. There are well-differentiated neuroendocrine neoplasms that should be classified as neuroendocrine tumors, in analogy to their gastrointestinal counterparts, however the nomenclature is inconsistent. The best defined entities are neuroendocrine tumors in the middle ear and ectopic pituitary adenoma in the sphenoid region. Poorly differentiated NENs most often arise in the olfactory organ and nasal cavity that are represented by olfactory neuroblastomas and poorly differentiated neuroendocrine carcinomas...
February 1, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29389737/intestinal-type-adenocarcinoma-of-the-sinonasal-tract-an-update
#17
Vittorio Rampinelli, Marco Ferrari, Piero Nicolai
PURPOSE OF REVIEW: Intestinal-type adenocarcinoma (ITAC) is one of the most frequent sinonasal tumors, especially in European countries. The purpose of this article is to review the most recent literature, with special emphasis on biological and genetic profile and treatment guidelines. RECENT FINDINGS: Results on large series support transnasal endoscopic surgery as the technique of choice in the large majority of patients with ITAC. Adjuvant radiotherapy is recommended in advanced-stage and high-grade lesions...
January 30, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29384975/different-characteristics-of-a-single-sinonasal-inverted-papilloma-from-sequential-pet-ct-a-case-report
#18
Jong Seung Kim, Sam Hyun Kwon
RATIONALE: Inverted papilloma (IP) is a benign tumor that should be monitored carefully because it frequently recurs and has the potential to become malignant. PATIENT CONCERNS: We report a case of a 59-year-old woman who presented with a mass which had been found incidentally on positron emission tomography computed tomography (PET CT). DIAGNOSES: Using endoscopy and CT, the preoperative diagnosis was inverted papilloma. PET CT showed a mass with hot uptake in the left ethmoid and frontal sinus (maximum standardized uptake value (SUVmax) = 7...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383488/-diagnostic-and-predictive-molecular-pathology-of-head-and-neck-neoplasms
#19
REVIEW
A Agaimy, W Weichert, F Haller, A Hartmann
As a result of some seminal observations as well as a consequence of increasing use of modern and innovative molecular diagnostic technologies, a variety of new genetic aberrations have been discovered in head and neck neoplasms of different anatomic locations and histogenetic origins. These advances resulted in the establishment of new molecularly defined disease entities. On the other hand, some of these new genetic biomarkers paved the way to potentially promising novel therapeutic opportunities. Diverse old (well known in other entities) and newly discovered translocations and gene fusions represent the leading subgroup of these genetic aberrations...
January 30, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29381644/schwannoma-of-the-membranous-nasal-septum-a-clinical-report-with-aesthetic-approach
#20
Yong-Ha Kim, Jin Ho Lee, Youngsoo Park, Kyu Jin Chung
Schwannoma is an uncommon tumor of nerve sheath that arises from any peripheral, cranial, or autonomic nerve. Only 4% of head and neck schwannomas originate from the sinonasal tract, and a finding of a schwannoma in the nasal septum is exceedingly rare. The authors experienced nasal septal schwannoma with the functional and aesthetic consideration of nasal contour. The authors present an open rhinoplasty approach for nasal septal schwannoma which has not been reported in the previous literature yet.
January 19, 2018: Journal of Craniofacial Surgery
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