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https://www.readbyqxmd.com/read/29211048/imaging-characteristics-of-malignant-sinonasal-tumors
#1
REVIEW
Masaya Kawaguchi, Hiroki Kato, Hiroyuki Tomita, Keisuke Mizuta, Mitsuhiro Aoki, Akira Hara, Masayuki Matsuo
Malignancies of the nasal cavity and paranasal sinuses account for 1% of all malignancies and 3% of malignancies of the upper aerodigestive tract. In the sinonasal tract, nearly half of all malignancies arise in the nasal cavity, whereas most of the remaining malignancies arise in the maxillary or ethmoid sinus. Squamous cell carcinoma is the most common histological subtype of malignant tumors occurring in this area, followed by other epithelial carcinomas, lymphomas, and malignant soft tissue tumors. Although many of these tumors present with nonspecific symptoms, each tumor exhibits characteristic imaging features...
December 6, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29210717/quality-of-life-outcomes-after-endoscopic-approaches-to-intracranial-tumors
#2
Madeleine R Schaberg
PURPOSE OF REVIEW: To review the literature on quality of life (QOL) in endoscopic approaches to anterior and central intracranial skull-base disease. As endoscopic surgical techniques have gained widespread acceptance and complications and morbidity remain low and comparable with microscopic and open approaches, a shift to focusing on patients' perception of their own well being as an important outcome parameter has been made. In addition to the traditional measurements of surgical outcomes (extent of resection, recurrence rate, morbidity, survival, and complication rate), the success of a surgery can now be assessed using QOL measures...
November 27, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29210531/comparison-of-endoscopic-and-open-resection-of-sinonasal-squamous-cell-carcinoma-a-propensity-score-matched-analysis-of-652-patients
#3
Suat Kılıç, Sarah S Kılıç, Soly Baredes, Richard Chan Woo Park, Omar Mahmoud, Jeffrey D Suh, Stacey T Gray, Jean Anderson Eloy
BACKGROUND: The use of endoscopic resection as an alternative to open surgery for sinonasal malignancies has increased in the past 20 years. METHODS: The National Cancer Database was queried for cases of sinonasal squamous cell carcinoma (SNSCC) without cervical or distant metastases that were treated surgically between 2010 and 2014. They were split into 2 groups based on surgical approach: open or endoscopic. Demographics, facility and insurance type, stage, tumor characteristics, postoperative treatment, 30-day readmission rate, 30- and 90-day mortality, and overall survival (OS) were compared between the 2 groups...
December 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29204580/etiology-of-sinonasal-inverted-papilloma-a-narrative-review
#4
REVIEW
Ming-Jie Wang, Julia E Noel
Objective: Sinonasal inverted papilloma (IP) is a benign and uncommon tumor of the nasal cavity and paranasal sinuses with a tendency for recurrence and even malignant transformation. Though the morphology and clinical behavior of this lesion has been well described, its etiology remains controversial. Methods: Computerized searches were performed in PubMed, Scopus, and Google scholar through May 2015. In this review, etiologic factors including human papilloma virus (HPV), Epstein-Barr virus (EBV), cell cycle related proteins and angiogenic factors, occupational and environmental exposures, and chronic inflammation, will be discussed...
March 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29193098/factors-associated-with-a-primary-surgical-approach-for-sinonasal-squamous-cell-carcinoma
#5
Jennifer R Cracchiolo, Krupa Patel, Jocelyn C Migliacci, Luc T Morris, Ian Ganly, Benjamin R Roman, Sean M McBride, Viviane S Tabar, Marc A Cohen
BACKGROUND AND OBJECTIVES: Primary surgery is the preferred treatment of T1-T4a sinonasal squamous cell carcinoma (SNSCC). METHODS: Patients with SNSCC in the National Cancer Data Base (NCDB) were analyzed. Factors that contributed to selecting primary surgical treatment were examined. Overall survival (OS) in surgical patients was analyzed. RESULTS: Four-thousand seven hundred and seventy patients with SNSCC were included. In T1-T4a tumors, lymph node metastases, maxillary sinus location, and treatment at high-volume centers were associated with selecting primary surgery...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29188178/tumor-shape-pulmonary-mucormycosis-associated-with-sinonasal-aspergillosis-in-a-diabetic-patient
#6
Sophie Point, Frédéric Gabriel, Hugues Bégueret, Jacques Jougon, Fanny Lanternier, Frédéric Grenouillet, Manal Abdel Fattah, Emilie Catherinot, Chantal Raherison, Elodie Blanchard
Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29174934/primary-lesions-that-may-imitate-metastatic-tumors-histologically-a-selective-review
#7
REVIEW
Mark R Wick
Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. This presentation considers a review of selected primary lesions that can simulate metastases. They include hemangioblastoma, glioblastoma and meningioma with epithelial metaplasia, choroid plexus carcinomas, primary neuroendocrine carcinomas in unusual locations, special forms of sinonasal and salivary glandular adenocarcinoma, clear-cell thyroid carcinomas, unusual microscopic subtypes of pulmonary adenocarcinoma, epithelioid myomelanocytomas ("sugar tumors"), mesotheliomas, primary thymic carcinomas, endodermal choristomas of the interatrial myocardium, peripheral cholangiocarcinoma, adrenocortical carcinoma, adenocarcinomas of the urinary bladder, mucinous and "rhabdoid" tumors of the ovaries, rete testis adenocarcinomas, interdigitating dendritic-cell sarcoma of lymph nodes, selected sweat gland carcinomas, cutaneous Merkel cell carcinoma, primary dermal and subcutaneous melanoma, mucosal and visceral melanomas, epithelioid sarcoma, clear-cell sarcoma, and adamantinoma of long bones...
November 17, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29168109/a-case-of-glomangiopericytoma-at-the-nasal-septum
#8
Takashi Anzai, Tsuyoshi Saito, Sho Tsuyama, Miri Toh, Katsuhisa Ikeda, Shin Ito
Glomangiopericytoma (GPC) is a rare sinonasal perivascular tumor that accounts for < 0.5-1% of all sinonasal tumors. GPC is categorized as a low-grade neoplasm with borderline malignancy and a tendency of local recurrence. GPC is a rare mesenchymal neoplasm characterized by the perivascular proliferation of tumor cells, and it requires being distinguished from solitary fibrous tumors. Here, we report a case of GPC in a 68-year-old male patient who presented at the emergency room of our hospital with a complaint of sudden epistaxis...
November 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29166820/sinonasal-smarcb1-ini1-deficient-carcinoma-with-yolk-sac-tumor-differentiation-report-of-a-case-and-comparison-with-ini1-expression-in-gonadal-germ-cell-tumors
#9
Michal Zamecnik, Jiri Rychnovsky, Jakub Syrovatka
SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a "common" morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. Immunohistochemically, it was diffusely negative for INI1, whereas an expression of yolk sac tumor markers (α-fetoprotein, glypican-3, CDX2) was limited to the yolk sac tumor component. For comparison with the present case, we performed INI1 immunostaining on a series of 11 gonadal germ cell tumors with yolk sac tumor differentiation...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29160775/anatomical-robust-optimization-to-account-for-nasal-cavity-filling-variation-during-intensity-modulated-proton-therapy-a-comparison-with-conventional-and-adaptive-planning-strategies
#10
Steven van de Water, Francesca Albertini, Damien Charles Weber, Ben J M Heijmen, Mischa S Hoogeman, Antony John Lomax
The aim of this study is to develop an anatomical robust optimization method for intensity-modulated proton therapy (IMPT) that accounts for interfraction variations in nasal cavity filling, and to compare it with conventional single-field uniform dose (SFUD) optimization and online plan adaptation. We included CT data of five patients with tumors in the sinonasal region. Using the planning CT, we generated for each patient 25 'synthetic' CTs with varying nasal cavity filling. The robust optimization method available in our treatment planning system 'Erasmus-iCycle' was extended to also account for anatomical uncertainties by including (synthetic) CTs with varying patient anatomy as error scenarios in the inverse optimization...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29145573/human-papillomavirus-hpv-and-somatic-egfr-mutations-are-essential-mutually-exclusive-oncogenic-mechanisms-for-inverted-sinonasal-papillomas-and-associated-sinonasal-squamous-cell-carcinomas
#11
A M Udager, J B McHugh, C M Goudsmit, H C Weigelin, M S Lim, K S J Elenitoba-Johnson, B L Betz, T E Carey, N A Brown
Background: Inverted sinonasal papilloma (ISP) is a locally aggressive neoplasm often associated with sinonasal squamous cell carcinoma (SNSCC). While the etiology of ISP is not well understood, human papillomavirus (HPV) has been detected in a subset of cases. Our group recently identified activating somatic EGFR mutations in the majority of ISP and ISP-associated SNSCC. However, the relationship between EGFR mutations and HPV infection has not been explored. Patients and Methods: We evaluated 58 ISP and 22 ISP-associated SNSCC (including 13 patients with matched ISP/SNSCC samples), as well as 14 SNSCC without clinical or pathologic evidence of an associated ISP...
November 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29145301/sinonasal-osteoblastomas-in-the-middle-turbinate-two-case-reports
#12
Jong Seung Kim, Sam Hyun Kwon
RATIONALE: Sinonasal osteoblastoma is an extremely rare benign bone-forming tumor. PATIENT CONCERNS: We report 2 extremely rare cases of sinonasal osteoblastoma in the middle turbinate. DIAGNOSES: The preoperative diagnosis was osteoma in the middle turbinate. INTERVENTIONS: We performed endoscopic removal of the mass in the middle turbinate and frontal recess. OUTCOMES: Histological examination of biopsy specimens revealed osteoblastoma...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142805/role-of-adjuvant-treatment-in-sinonasal-mucosal-melanoma
#13
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
Purpose  Sinonasal mucosal melanoma (SNMM) is a locally aggressive tumor. This study aimed to define the role of adjuvant treatment and its association with survival outcomes of SNMM. Methods  This retrospective study investigated 152 patients with SNMM treated between 1991 and 2016 in MD Anderson Cancer Center. Patients were divided into the following treatment groups: surgery alone, surgery with postoperative radiotherapy (PORT), surgery with postoperative chemoradiation (POCRT), and induction chemotherapy followed by surgery and PORT...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29137081/sinonasal-undifferentiated-carcinoma-originating-from-inverted-papilloma-a-case-report
#14
Jong Seung Kim, Ki Hwan Hong, Kyu Yun Jang, Jong Hoon Song
RATIONALE: Sinonasal inverted papilloma (IP) is a locally aggressive tumor found in the schneiderian membrane, lining the nasal cavity and paranasal sinuses. PATIENT CONCERNS: We report a case of a 63-year-old woman with undifferentiated carcinoma (UC) arising in an IP in the left maxillary sinus. DIAGNOSES: The preoperative diagnosis was IP of the maxillary sinus. INTERVENTIONS: We performed endoscopic medial maxillectomy to remove the remnant mass in the left maxillary sinus...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136692/-expression-and-prognostic-values-of-pd-1-pd-l1-and-ido-1-in-sinonasal-malignant-mucosal-melanoma
#15
H Q Liu, B Q Zou, S Y Wang
Objective: To investigate the correlation between the expression of programmed death-1(PD-1), PD ligand-1(PD-L1), indoleamine 2, 3-dioxygenase 1(IDO-1) and clinical parameters in sinonasal malignant mucosal melanoma (SNM). Methods: Samples from 86 SNM patients who did not receive immune-targeted therapy and radio-chemotherapy were analyzed for PD-1, PD-L1, and IDO-1 expression by immunohistochemistry. Results: High clinical/pathologic staging, brain metastases and advanced age were independent risk factors of poor prognosis...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29122079/sinonasal-t-cell-expression-of-cytotoxic-mediators-granzyme-b-and-perforin-is-reduced-in-patients-with-chronic-rhinosinusitis
#16
Sarah E Smith, Rodney J Schlosser, James R Yawn, Jose L Mattos, Zachary M Soler, Jennifer K Mulligan
BACKGROUND: CD8+ T cells and natural killer (NK) cells are cytotoxic cells that use granzyme B (GrB) and perforin. Defective cytotoxic function is known to play a role in dysregulated immune response as seen in chronic sinusitis, also referred to as chronic rhinosinusitis (CRS). However, to our knowledge, in the United States, neither GrB or perforin expression has been reported in patients with CRS. OBJECTIVE: The aim of this study was to investigate sinonasal cytotoxic cells, their mediators, and cell-specific distribution of these mediators in patients with CRS with nasal polyp (CRSwNP) and in patients with CRS without nasal polyp (CRSsNP)...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29121373/pediatric-sinonasal-desmoid-tumor
#17
Jonathan Choi, Evan Walgama, John McClay, Pete S Batra, Ron B Mitchell
No abstract text is available yet for this article.
October 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29114957/sinonasal-cancer-in-the-italian-national-surveillance-system-epidemiology-occupation-and-public-health-implications
#18
Alessandra Binazzi, Marisa Corfiati, Davide Di Marzio, Anna M Cacciatore, Jana Zajacovà, Carolina Mensi, Paolo Galli, Lucia Miligi, Roberto Calisti, Elisa Romeo, Alessandro Franchi, Alessandro Marinaccio
BACKGROUND: Sinonasal cancer (SNC) is a rare tumor with predominant occupational etiology associated with exposures to specific carcinogens. The aim of this study is to describe SNC cases recorded in Italy in the period 2000-2016. METHODS: Clinical information, occupational history, and lifestyle habits of SNC cases collected in the Italian Sinonasal Cancer Register were examined. Age-standardized rates were estimated. RESULTS: Overall, 1529 cases were recorded...
November 7, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29103747/the-clinicopathological-spectrum-of-olfactory-neuroblastoma-and-sinonasal-neuroendocrine-neoplasms-refinements-in-diagnostic-criteria-and-impact-of-multimodal-treatments-on-survival
#19
Mario Turri-Zanoni, Roberta Maragliano, Paolo Battaglia, Marta Giovannardi, Paolo Antognoni, Davide Lombardi, Maria Laura Morassi, Ernesto Pasquini, Paolo Tarchini, Sofia Asioli, Maria Pia Foschini, Fausto Sessa, Piero Nicolai, Paolo Castelnuovo, Stefano La Rosa
OBJECTIVES: To provide a comprehensive review of the clinical and histopathological features of olfactory neuroblastoma (ONB) and other sinonasal neuroendocrine neoplasms (NENs), in order to refine diagnostic criteria, analyze treatment outcomes, and identify prognostic factors. METHODS: Data from an Italian multi-institutional database were analyzed. Patients were treated surgically via a minimally-invasive endoscopic approach followed by adjuvant radiotherapy or radiochemotherapy...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29095708/updates-in-the-management-of-sinonasal-mucosal-melanoma
#20
Meghan M Crippen, Suat Kılıç, Jean A Eloy
PURPOSE OF REVIEW: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with a poor prognosis. Although there is significant study surrounding the treatment of sinonasal malignancies and cutaneous melanomas, the rarity of this tumor has largely precluded robust outcomes analyses. The authors of this review seek to provide an overview of the recent literature related to the treatment of SNMM with added context from our institutional experience with this disease. RECENT FINDINGS: In the surgical management of sinonasal malignancies and SNMM specifically, resection via endoscopic endonasal technique appears to offer comparable oncologic outcomes versus an open approach...
October 31, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
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