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https://www.readbyqxmd.com/read/29668071/human-papillomavirus-an-unlikely-etiologic-factor-in-sinonasal-inverted-papilloma
#1
Sepideh Mohajeri, Chi Lai, Bibianna Purgina, Dakheelallah Almutairi, Tabassom Baghai, Jim Dimitroulakos, Shaun Kilty
OBJECTIVES/HYPOTHESIS: Tenuous evidence has supported the hypothesis that sinonasal inverted papilloma (SNIP) arise from human papillomavirus (HPV) infection. To clarify the role of HPV in SNIP, all known HPV sub-types were evaluated by employing a robust polymerase chain reaction-based method in a wide variety of SNIPs from a single institution. STUDY DESIGN: Retrospective surgical specimen tumor sample analysis. METHODS: HPV positivity among SNIP samples and those with squamous cell carcinoma (SCC) were compared...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29661053/differential-diagnosis-of-sinonasal-lymphoma-and-squamous-cell-carcinoma-on-ct-mri-and-pet-ct
#2
Seok-Hyun Kim, Sue-Jean Mun, Hak-Jin Kim, Seon Lin Kim, Sung-Dong Kim, Kyu-Sup Cho
Objective The purpose of this study was to analyze computed tomography (CT) and magnetic resonance (MR) images and to evaluate the maximum standardized uptake value (SUV max) of positron emission tomography (PET)/CT parameters between sinonasal non-Hodgkin's lymphoma (NHL) and squamous cell carcinoma (SCC), knowing the imaging features that distinguish sinonasal NHL from SCC. Study Design Case series with chart review. Setting University tertiary care facility. Subjects and Methods We analyzed the features on CT, MR imaging, and PET/CT of 78 patients diagnosed with sinonasal NHL or SCC histopathologically...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29660598/first-in-human-phase-1-dose-escalation-pharmacokinetic-and-pharmacodynamic-study-of-the-oral-dual-pi3k-and-mtorc1-2-inhibitor-pqr309-in-patients-with-advanced-solid-tumors-sakk-67-13
#3
Andreas Wicki, Nicholas Brown, Alexandros Xyrafas, Vincent Bize, Hanne Hawle, Simona Berardi, Nataša Cmiljanović, Vladimir Cmiljanović, Michael Stumm, Saša Dimitrijević, Richard Herrmann, Vincent Prêtre, Reto Ritschard, Alexandar Tzankov, Viviane Hess, Alexa Childs, Cinta Hierro, Jordi Rodon, Dagmar Hess, Markus Joerger, Roger von Moos, Cristiana Sessa, Rebecca Kristeleit
BACKGROUND: PQR309 is an orally bioavailable, balanced pan-phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) C1 and mTORC2 inhibitor. PATIENTS AND METHODS: This is an accelerated titration, 3 + 3 dose-escalation, open-label phase I trial of continuous once-daily (OD) PQR309 administration to evaluate the safety, pharmacokinetics (PK) and pharmacodynamics in patients with advanced solid tumours. Primary objectives were to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D)...
April 13, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29658783/fibrosarcoma-arising-in-the-paranasal-sinus-a-clinicopathological-and-radiological-analysis
#4
Junjie Zeng, Huaping Liu, Lizhi Liu, Weihua Liao, Ping Hu, Xiaoyi Wang, Xuejun Li, Lunquan Sun, Youming Zhang, Xiaoping Yi
OBJECTIVES: To analyze the clinicopathological features and the CT and MRI features of patients with paranasal sinus fibrosarcoma. METHODS: Seven patients with surgically and pathologically confirmed paranasal sinus fibrosarcoma were enrolled. Their CT and MRI data and imaging features were retrospectively analyzed in detail. RESULTS: The study participants were two males and five females (median age, 43 years; range, 22-73 years). CT or MRI imaging showed a well-defined (n = 5) or ill-defined (n = 2), irregular (n = 6) or oval (n = 1) mass, with heterogeneous (n = 7) density...
April 16, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29649889/endoscopic-resection-of-sinonasal-inverted-papillomas-systematic-review-and-meta-analysis
#5
John K Goudakos, Sarantis Blioskas, Angelos Nikolaou, Konstantinos Vlachtsis, Peter Karkos, Konstantinos D Markou
Background Pure endoscopic surgery (functional endoscopic sinus surgery) has been increasingly replacing external approaches in the management of sinonasal inverted papillomas. Objective To analyze and compare the effectiveness of pure endoscopic procedure with external or combined procedures to paranasal inverted papillomas, including the experience from two institutions in North Greece, over a 20-year period. Methods Systematic literature searches of MEDLINE (1952-2016), EMBASE (1974-2016), and the Cochrane Central Register of Controlled Trials...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644901/eccentric-mature-osseous-cap-a-distinct-imaging-feature-of-sinonasal-osteoblastoma
#6
Sumeet G Dua, Philip H Locker, Isolina R Rossi, Danny Jandali, Paulo Gattuso, Pete S Batra, Bobby A Tajudeen
BACKGROUND: With the exception of osteomas, bone neoplasms that originate in the sinonasal cavity are seldom diagnosed on preoperative imaging due to a lack of characteristic radiographic features. Here we described the unusual occurrence of an osteoblastoma in the paranasal sinuses, and we drew focus to its salient imaging features. A highly unique imaging sign was indicated, and its pathologic basis was explained, with concurrent review of the literature. METHODS: Case series and review of the literature...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644900/discordance-in-preoperative-and-postoperative-histopathology-of-sinonasal-tumors
#7
Ashwin Ganti, Bobby A Tajudeen, Max A Plitt, Isolina Rossi, Paolo Gattuso, Pete S Batra
Background Head and neck surgical pathology has been shown to be prone to histopathologic diagnostic error that can adversely impact patient care due to inappropriate management. Sinonasal tumors, in particular, present a diagnostic challenge given the relative rarity and diversity in histology and thus may have higher rates of discordant histology. Objective The purpose of this study is to determine the rate of discrepancy between preoperative and postoperative diagnoses of sinonasal tumors. Methods Retrospective chart review was performed on 52 patients treated for sinonasal tumors between January 2013 and December 2016...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29626308/patterns-of-treatment-failure-in-patients-with-sinonasal-mucosal-melanoma
#8
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
BACKGROUND: Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites. OBJECTIVE: The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure. METHODS: This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29616903/sinonasal-ewing-sarcoma-a-case-report-and-literature-review
#9
Jonathan K Lin, Jonathan Liang
INTRODUCTION: Ewing sarcoma (ES) of the sinonasal tract and associated primitive neuroectodermal tumors are rare. To our knowledge, only 10 case reports of sinonasal ES of the nose or paranasal sinuses have been reported. Furthermore, there has been only 1 case of sinonasal ES arising from the middle turbinate. Recommended management of sinonasal ES stems from the management of its osseous counterpart, ES, but treatment with surgery, radiotherapy, and chemotherapy is varied. Five-year survival rates vary from 21% to 70%, with the lower rates representing patients presenting with metastatic disease...
March 7, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29606049/transbasal-versus-endoscopic-endonasal-versus-combined-approaches-for-olfactory-groove-meningiomas-importance-of-approach-selection
#10
James K Liu, Nicole A Silva, Ilesha A Sevak, Jean Anderson Eloy
OBJECTIVE There has been much debate regarding the optimal surgical approach for resecting olfactory groove meningiomas (OGMs). In this paper, the authors analyzed the factors involved in approach selection and reviewed the surgical outcomes in a series of OGMs. METHODS A retrospective review of 28 consecutive OGMs from a prospective database was conducted. Each tumor was treated via one of 3 approaches: transbasal approach (n = 15), pure endoscopic endonasal approach (EEA; n = 5), and combined (endoscope-assisted) transbasal-EEA (n = 8)...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29595682/salvage-preoperative-embolization-of-an-infratemporal-solitary-fibrous-tumor-a-case-report-with-review-of-the-literature
#11
Kabalane Yammine, Haydar A Nasser, Usama Hadi, Mohamad Ali Natout, Vicky Najjar, Claude Tayar
RATIONALE: Head and Neck Solitary fibrous tumors (SFT) are very rare. They could be misdiagnosed as hemangiopericytomas (HPC). PATIENT CONCERNS: We report a 60 y o lady presenting with sinonasal mass, causing recurrent profuse bleeding. DIAGNOSES: Hemangioperocytomas versus SFT were among the differentials, according to Radiological studies. Upon Biopsy, the diagnosis of SFT has been adopted. INTERVENTIONS: Salvage pre-operative embolization resulted in bleeding control, bridging the patient to surgery...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29581953/organized-hematoma-of-temporomandibular-joint
#12
Chena Lee, Jong In Yook, Sang-Sun Han
Organized hematoma is a pseudo-tumorous lesion mostly occurs at sinonasal cavity and often confused with malignant neoplasm. The initiation of this lesion is blood accumulation, probably due to trauma, and this hematoma develops into organized hematoma as it encapsulated with fibrous band and neo-vascularized. Since it is uninformed at temporomandibular joint (TMJ) region, imaging diagnosis might be challenging. Also, delayed detection of mass involving TMJ is not uncommon due to confusion with joint disorder...
March 2018: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/29581595/elevated-dna-methylation-in-malignant-tumors-of-the-sinonasal-tract-and-its-association-with-patient-survival
#13
Marcela Chmelarova, Jan Laco, Helena Kovarikova, Ivana Baranova, Pavel Dundr, Kristyna Nemejcova, Jaroslav Michalek, Milan Vosmik, Vladimir Palicka
BACKGROUND: Epigenetic modifications have been recognized as an important mechanism underlying carcinoma progression. DNA methylation plays an important role in cancer biology and represents potentially heritable changes in gene expression that do not involve DNA sequence. The aim of this study was to investigate promoter methylation of selected genes in sinonasal carcinoma by comparison with noncancerous sinonasal tissue. METHODS: To search for epigenetic events (methylation in 25 tumor suppressor genes) we used MS-MLPA (Methylation-specific multiplex ligation-dependent probe amplification) to compare methylation status of 59 formalin fixed, paraffin embedded tissue samples of sinonasal carcinomas with 18 control samples...
March 27, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29566950/biphenotypic-sinonasal-sarcoma-a-series-of-six-cases-with-evaluation-of-role-of-%C3%AE-catenin-immunohistochemistry-in-differential-diagnosis
#14
Aanchal Kakkar, Madhu Rajeshwari, Pirabu Sakthivel, Mehar C Sharma, Suresh C Sharma
INTRODUCTION: Biphenotypic sinonasal sarcoma (BSNS) is a recently described mesenchymal tumor exclusive to the sinonasal region. It is a low grade sarcoma, displaying evidence of myogenic and neural differentiation. Role of β-catenin immunohistochemistry in distinguishing it from its morphological mimics is not well-established. We conducted this study to identify cases of BSNS from our archives, and to examine immunopositivity for β-catenin in them as well as in its close differential diagnosis...
April 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29554067/osteosarcoma-of-the-ethmoid-sinus
#15
Zülküf Burak Erdur, Emine Deniz Gözen, Hakki Caner Inan, Haydar Murat Yener, Nil Çomunoğlu, Cansu Yol, Çiğdem Papila, Harun Cansiz
Osteosarcoma (OS) is a malignant bone tumor and it is very rare in head and neck region. If it arises in this area, most common localizations of this tumor are mandible and maxilla and ethmoid sinus is very rare site for this malignancy. A 43-year-old female admitted to our clinic with the complaint of pain in the right half of the face and headache persisting for 2 months. According to the clinical symptoms and imaging studies, sinonasal ossifying fibroma was suspected. For this reason, patient was operated endoscopically and histopathological examination revealed that osteoid matrix producing atypical osteoblastic cells so these findings identified osteoblastic variant OS...
March 16, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29548524/clinical-features-of-nasal-and-sinonasal-inverted-papilloma-associated-with-malignancy
#16
Takuya Miyazaki, Yasuharu Haku, Akira Yoshizawa, Ken Iwanaga, Takashi Fujiwara, Masanobu Mizuta, Atsuhiro Yoshida, Shinichi Satou, Hisanobu Tamaki
OBJECTIVE: Nasal and sinonasal inverted papilloma (IP) are rare benign tumors and have the potential to exhibit malignancy in approximately 10% of cases. This study aimed to analyze the clinical features of IP associated with malignancy. Furthermore, we reviewed our therapeutic strategy and the clinical course of malignant IP. METHODS: Overall, 70 patients with IP at our institution were retrospectively analyzed from April 2006 to December 2015; of these, six (9%) had associated malignancy...
March 13, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29547549/hpv-virus-transcriptional-status-assessment-in-a-case-of-sinonasal-carcinoma
#17
Gennaro Ilardi, Daniela Russo, Silvia Varricchio, Giovanni Salzano, Giovanni Dell'Aversana Orabona, Virginia Napolitano, Rosa Maria Di Crescenzo, Alessandra Borzillo, Francesco Martino, Francesco Merolla, Massimo Mascolo, Stefania Staibano
Human Papilloma Virus (HPV) can play a causative role in the development of sinonasal tract malignancies. In fact, HPV may be the most significant causative agent implicated in sinonasal tumorigenesis and is implicated in as many as 21% of sinonasal carcinomas. To date, there are no definitive, reliable and cost-effective, diagnostic tests approved by the FDA for the unequivocal determination of HPV status in head and neck cancers. We followed an exhaustive algorithm to correctly test HPV infection, including a sequential approach with p16INK4a IHC, viral DNA genotyping and in situ hybridization for E6/E7 mRNA...
March 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29543674/mammary-analog-secretory-carcinoma-of-the-nasal-cavity-characterization-of-2-cases-and-their-distinction-from-other-low-grade-sinonasal-adenocarcinomas
#18
Martina Baneckova, Abbas Agaimy, Simon Andreasen, Tomas Vanecek, Petr Steiner, David Slouka, Tomas Svoboda, Marketa Miesbauerova, Michael Michal, Alena Skálová
Secretory carcinoma, originally described as mammary analog secretory carcinoma (MASC), is a low-grade salivary gland tumor characterized by a t(12;15)(p13;q25) translocation, resulting in an ETV6-NTRK3 gene fusion. Most MASCs are localized to the parotid gland and intraoral minor salivary glands. Moreover, ETV6-rearranged carcinomas with secretory features have been reported recently in the thyroid (with and without a history of radiation exposure), skin, and in very rare instances in the sinonasal tract. Here, we describe 2 cases of primary MASC in the sinonasal tract and provide a detailed clinical and histopathologic characterization of their morphology, immunohistochemical profile, and genetic background and highlight features allowing for its separation from its recently described molecular mimicker, ETV6-rearranged low-grade sinonasal adenocarcinoma...
March 14, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29465436/orbital-exenteration-for-sinonasal-malignancies-indications-rehabilitation-and-oncologic-outcomes
#19
José G Vartanian, Ronaldo N Toledo, Thiago Bueno, Luiz P Kowalski
PURPOSE OF REVIEW: Review the recent literature regarding the management of orbital invasion in sinonasal malignant tumors. RECENT FINDINGS: There is a recent trend in preserving the orbit in cases of minimal invasion of periosteum and limited periorbit involvement, as well as in presence of good response to neoadjuvant chemotherapy, mainly in squamous cell carcinoma and neuroendocrine histologies. SUMMARY: The decision about orbital exenteration in cases of sinonasal malignancies is facilitated if the patient already has clear clinical signs of intraconal invasion such as visual loss, restriction of ocular mobility or infiltration of the eyeglobe...
April 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29459588/magnetic-resonance-imaging-in-evaluation-of-sinonasal-masses-with-histopathological-correlation
#20
M S Begum, U K Sarker, M A Islam, M A Sangma, P Paul, M A Rahman
Sinonasal mass is the abnormal growth of tissue from nasal cavity and mucosa of the paranasal sinuses. The growth may be benign or malignant. The benign lesion grows slowly and does not metastasize. The malignant lesion grows rapidly and metastasizes early. The aim of this study is to evaluate and diagnose the various types of sinonasal masses with MRI and its correlation with histopathological findings. This cross sectional descriptive study was carried out for a period of 02 years, from July 2015 to June 2017...
January 2018: Mymensingh Medical Journal: MMJ
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