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https://www.readbyqxmd.com/read/28092140/a-systematic-review-of-sinonasal-oncocytomas-and-oncocytic-carcinomas-diagnosis-management-and-technical-considerations
#1
REVIEW
Zerina Hodzic, Nicholas R Rowan, Ryota Kashiwazaki, Thomas J Willson, Eric W Wang, Stella E Lee
BACKGROUND: Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS: A systematic literature review was performed using PubMed and Ovid databases. The data obtained from published articles with sinonasal oncocytoma/oncocytic carcinoma as the primary diagnosis included patient demographics, presentation, radiographic and histologic findings, management, and recurrence rates...
January 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28069272/smarcb1-ini1-deficient-sinonasal-carcinoma-shows-methylation-of-rassf1-gene-a-clinicopathological-immunohistochemical-and-molecular-genetic-study-of-a-recently-described-entity
#2
Jan Laco, Marcela Chmelařová, Hana Vošmiková, Kateřina Sieglová, Ivana Bubancová, Pavel Dundr, Kristýna Němejcová, Jaroslav Michálek, Petr Čelakovský, Radovan Mottl, Igor Sirák, Milan Vošmik, Aleš Ryška
The aim of the study was detailed clinicopathological investigation of SMARCB1/INI1-deficient sinonasal carcinomas, including molecular genetic analysis of mutational status and DNA methylation of selected protooncogenes and tumor suppressor genes by means of next generation sequencing (NGS) and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA). A total of 4/56 (7%) cases of SMARCB1/INI1-deficient carcinomas were detected among 56 sinonasal carcinomas diagnosed over a 19year period using immunohistochemical screening...
October 25, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28063243/local-extension-staging-of-sinonasal-tumors-retrospective-comparison-between-ct-mri-assessment-and-pathological-findings
#3
Geoffrey Mortuaire, Domitille Camous, Claire Vandenhende-Szymanski, Frédérique Dubrulle, Dominique Chevalier
OBJECTIVES: To assess the reliability of clinical staging with CT and MRI in sinonasal cancers. METHODS: We conducted a retrospective review of patients who underwent surgery for a sinonasal cancer. The 7(th) edition of the TNM classification was used to establish tumor staging. Standardized preoperative CT/MRI staging was compared with the pathological staging based on specimens obtained during surgery from each subsite within and around the tumor. RESULTS: We analyzed data from 68 patients between January 2010 and December 2014...
January 7, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28060373/small-round-blue-cell-tumors-of-the-sinonasal-tract-a-differential-diagnosis-approach
#4
Lester Dr Thompson
One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28060369/virus-associated-neoplasms-of-the-nasopharynx-and-sinonasal-tract-diagnostic-problems
#5
John Kc Chan
A significant fraction of nasopharyngeal and sinonasal tumors are associated with Epstein-Barr virus (EBV) or human papillomavirus (HPV). Nasopharyngeal carcinoma (NPC) and extranodal NK/T-cell lymphoma harbor EBV in practically all cases, although a small proportion of cases of the former harbor HPV. Sinonasal inverted papillomas harbor HPV in about 25% of cases. Sinonasal squamous cell carcinomas harbor transcriptionally active HPV in about 20% of cases, and limited data suggest that this subset has a better prognosis than the HPV-negative subset...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28044299/mucosal-malignant-melanoma-of-nasal-cavity-recurring-a-year-after-radiotherapy
#6
Cem Çomunoğlu, Gamze Mocan Kuzey, Mete Inançli, Füsun Baba, Hanife Özkayalar
OBJECTIVE: Sinonasal mucosal malignant melanoma is a rare entity. In this report we present a nasal mucosal malignant melanoma case with its histopathological and clinical features. CASE REPORT: An 88-year-old female patient presented with epistaxis a month ago. Examination revealed a polypoid mass lesion of right nasal cavity originating from the middle concha. Her medical history revealed that she had been found to have a mass lesion in the right nasal cavity 15 months ago...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28032937/prognostic-value-of-pretreatment-peripheral-blood-markers-in-paranasal-sinus-cancer-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio
#7
Mario Turri-Zanoni, Giovanni Salzano, Alessia Lambertoni, Marta Giovannardi, Apostolos Karligkiotis, Paolo Battaglia, Paolo Castelnuovo
BACKGROUND: Pretreatment hematological markers have emerged as prognostic factors for several cancers. The purpose of this study was to present our investigation of the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting recurrence and mortality for patients with primary sinonasal cancers (SNCs). METHODS: We carried out a retrospective review of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014 at a single institute...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28032687/transnasal-endoscopic-partial-maxillectomy-operative-nuances-and-proposal-for-a-comprehensive-classification-system-based-on-1378-cases
#8
Mario Turri-Zanoni, Paolo Battaglia, Apostolos Karligkiotis, Davide Lepera, Jacopo Zocchi, Iacopo Dallan, Maurizio Bignami, Paolo Castelnuovo
BACKGROUND: Despite the development of functional endoscopic endonasal surgery, there are still areas of the maxillary sinus that remain technically difficult to access using a standard middle meatal antrostomy as well as deep-seated skull base lesions requiring expanded transmaxillary approaches. METHODS: All patients who underwent transnasal endoscopic partial maxillectomy (TEPM) in a single institution from 2000 to 2014 were retrospectively reviewed. The TEPM was classified into 5 types according to the anatomic structures progressively removed and to the access provided...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28011179/therapy-of-sinonasal-malignancies-invading-the-orbit-orbital-exenteration-versus-preservation-of-the-orbit-plus-radiotherapy
#9
Ali-Farid Safi, Lars Behn, Daniel Rothamel, Orlando Guntinas-Lichius, Dirk Beutner, Hans-Joachim Nickenig, Joachim Zöller, Matthias Kreppel
INTRODUCTION: Orbital invasion is a strong independent prognostic factor for sinonasal malignancies. While there is consent about preservation of the orbit for tumors limited to the orbital periosteum there is controversy about the optimal management of sinonasal malignancies transgressing this barrier. Therefore the aim of our study was to compare exenteration versus preservation of the orbit. MATERIAL AND METHODS: 52 patients with sinonasal malignancies invading the orbit beyond the orbital periosteum with involvement of the orbital soft tissues were included in the retrospective study...
November 30, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28009611/pituitary-adenomas-presenting-as-sinonasal-or-nasopharyngeal-masses-a-case-series-illustrating-potential-diagnostic-pitfalls
#10
Martin D Hyrcza, Shereen Ezzat, Ozgur Mete, Sylvia L Asa
We present a series of nonectopic pituitary adenomas presenting as polypoid sinonasal or nasopharyngeal masses. Thirteen cases diagnosed by biopsies from the nasal cavity, sinuses, or nasopharynx were identified from a series of 1288 surgical pituitary specimens. The patients included 5 men and 8 women ranging from 29 to 69 years of age. The presentations included nasal obstruction (4 cases), headaches (3), visual defects (2), recurrent nose bleeds (1), rhinorrhea (1), sepsis (1), fatigue (1), and hyperthyroidism (1)...
December 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28009605/melanotic-pecoma-of-the-sinonasal-mucosa-with-nono-tfe3-fusion-an-elusive-mimic-of-sinonasal-melanoma
#11
Stephanie M McGregor, Mir B Alikhan, Rahel A John, Howard Kotler, Julia A Bridge, Ibro Mujacic, Sabah Kadri, Jeremy Segal, Thomas Krausz
Perivascular epithelioid cell neoplasms (PEComas) are a family of mesenchymal tumors with features of both smooth muscle and melanocytic differentiation, with or without true melanin pigment. The highly variable morphology of PEComas results in a broad differential diagnosis that is also dependent on anatomic site. A subset demonstrates rearrangements involving the TFE3 (Xp11) locus, which can be used in diagnostically difficult cases. Here we describe a case of a melanotic PEComa with NONO-TFE3 fusion occurring in the sinonasal mucosa, as demonstrated by both next-generation sequencing and molecular cytogenetic studies...
December 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27958666/sinusitis-in-patients-on-tumor-necrosis-factor-alpha-inhibitors
#12
Cynthia S Wang, Adam Honeybrook, Nikita Chapurin, Anjeni Keswani, David W Jang
BACKGROUND: Tumor necrosis factor alpha (TNF-α) inhibitors have revolutionized treatment of many inflammatory diseases. Sinusitis after initiation of TNF-α inhibitors has been observed, but has not been well described in the literature. We aim to characterize the clinical features of sinusitis in patients on anti-TNF-α therapy. METHODS: This is a retrospective chart review of 28 patients on a TNF-α inhibitor diagnosed with sinusitis by otolaryngologists at Duke University...
December 13, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27938993/meta-analysis-of-701-published-cases-of-sinonasal-neuroendocrine-carcinoma-the-importance-of-differentiation-grade-in-determining-treatment-strategy
#13
REVIEW
Tom P van der Laan, René Iepsma, Max J H Witjes, Bernard F A M van der Laan, Boudewijn E C Plaat, Gyorgy B Halmos
The aim of this meta-analysis was to provide treatment guidelines for sinonasal neuroendocrine carcinoma (SNC) by combining all available data in the literature. A literature search for all studies concerning SNC was performed against the MEDLINE and EMBASE databases. Available clinical data was normalized, pooled, and statistically analyzed. A total of 701 cases of SNC were available for analysis, comprising 127 well or moderately differentiated sinonasal neuroendocrine carcinomas (SNEC), 459 sinonasal undifferentiated carcinoma (SNUC) and 115 sinonasal small cell carcinoma (SmCC)...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27930867/squamous-cell-carcinoma-associated-with-inverted-papilloma-of-the-maxillary-sinus-our-experience-with-21-patients
#14
Myeong Sang Yu, Won Sub Lim, Bong-Jae Lee, Yoo-Sam Chung
Sinonasal inverted papillomas (IP) are benign tumors, which represent 0.5-7.0% of all diagnosed sinonasal tumors,(1) and exhibit malignant characteristics, including high rates of recurrence and local aggressiveness and association with malignancy.(1) The incidence of IP associated with SCC differs widely according to various reports (2-53%).(2,3) IP-associated SCC is not considered to be simply a mixture of the two other primary tumors, but rather a malignant transformation of the IP.(3) This article is protected by copyright...
December 8, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27916624/primary-paranasal-sinus-clear-cell-carcinoma-with-ewsr1-atf1-fusion-report-of-two-molecularly-confirmed-cases-exhibiting-unique-histopathology
#15
Jui Lan, Shun-Chen Huang, Yi-Hsien Chen, Wei-Chih Chen, Ying-Tai Jin, Ying-Chou Lu, Chih-Yen Chien, Hsuan-Ying Huang
Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumor of the salivary glands made up of clear cells that form cords and nests in hyalinized stroma. To date, primary HCCCs of the paranasal sinus have not been described. This article presents two cases of HCCC of the maxillary sinus with unusual glandular formation and lymphoplasmacytic stroma in Case 1 and a characteristic solid nest pattern and fibrocellular and hyalinized stroma in Case 2. Immunohistochemical studies excluded myoepithelial origin and sinonasal renal cell-like adenocarcinomas...
December 1, 2016: Human Pathology
https://www.readbyqxmd.com/read/27906054/is-radical-surgery-of-an-inverted-papilloma-of-the-maxillary-sinus-obsolete-a-case-report
#16
Vedat Yildirim, Niels Christian Pausch, Dirk Halama, Heinz-Theo Lübbers, Ayhan Yildirim
BACKGROUND: Sinonasal inverted papilloma is a locally aggressive tumor arising from the Schneiderian membrane which lines the nasal cavity and paranasal sinuses. Aggressive surgical approaches, such as lateral rhinotomy, were used until recently for complete removal of the inverted papilloma. Currently, endoscopic resection is the gold standard in the treatment of inverted papilloma. However, there are situations that justify an open approach. For example there are studies that report a higher postoperative recurrence rate after endonasal endoscopic resection, particularly in the treatment of recurrent diseases...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27898190/primary-ewing-s-sarcoma-of-the-sinonasal-tract-in-adults-a-challenging-disease
#17
Davide Lombardi, Davide Mattavelli, Luca O Redaelli De Zinis, Remo Accorona, Maria L Morassi, Fabio Facchetti, Vittorio Ferrari, Davide Farina, Rossella Bertulli, Piero Nicolai
BACKGROUND: Sinonasal localization of Ewing's sarcoma in adults is an exceedingly rare event. METHODS: The clinical records of 5 patients with primary sinonasal Ewing's sarcoma treated from 1992 to 2012 were retrospectively analyzed. All pathologic slides were reviewed by 2 experienced pathologists. All patients underwent multimodality treatments. RESULTS: Median age was 36 years (range, 25-52 years). At referral, 2 patients had the original diagnosis changed by review of the histologic slides...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27896549/embryonal-rhabdomyosarcoma-in-a-patient-with-a-heterozygous-frameshift-variant-in-the-dicer1-gene-and-additional-manifestations-of-the-dicer1-syndrome
#18
Julia Fremerey, Stefan Balzer, Triantafyllia Brozou, Joerg Schaper, Arndt Borkhardt, Michaela Kuhlen
Germline mutations in the DICER1 gene are associated with an inherited cancer predisposition syndrome also known as the DICER1-syndrome, which is implicated in a broad range of tumors including pleuropulmonary blastoma, ovarian Sertoli-Leydig cell tumors, ciliary body medulloepithelioma (CBME), pituitary blastoma, embryonal rhabdomyosarcoma (eRMS), anaplastic renal sarcoma as well as ocular, sinonasal tumors ovarian sex-cord tumors, thyroid neoplasia and cystic nephroma. This study describes a novel, heterozygous frameshift DICER1 mutation in a patient, who is affected by different tumors of the DICER1-syndrome, including eRMS, CBME and suspected pleuropulmonary blastoma type I...
November 28, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27894610/-reconstruction-of-proximal-nasal-defect-after-deep-carcinological-resection-interest-to-combine-titane-mesh-with-fat-grafting
#19
R Aimard, C Lalloué, C Ho Quoc, D Girodet, P Zrounba, E Delay
INTRODUCTION: The mucosal cylindroma or adenoid cystic carcinoma is the second sinonasal non-epithelial malignant tumor frequency argument. Due to the achievement of the nasal mucosa and a late diagnosis reconstructions are often complex. We report the case of a mucous cylindroma recurrence of nasal septum requiring a wide and deep excision of the root of the nose with nasal reconstruction. CASE REPORT: A patient aged 66 years whose history resection two years ago with a mucous adenoid cystic carcinoma of the right side of the nasal septum, had a local recurrence T2NOM0 imposing a wide excision with amputation nasal septum own bones of nose, the anterior portion of the triangular cartilages...
November 25, 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27859278/outcomes-of-nonsurgical-management-of-locally-advanced-carcinomas-of-the-sinonasal-cavity
#20
Shamit Chopra, Dev P Kamdar, David S Cohen, Lance K Heilbrun, Daryn Smith, Harold Kim, Ho-Sheng Lin, John R Jacobs, George Yoo
OBJECTIVE: To determine the outcome of definitive concurrent chemoradiation with platinum for locally advanced sinonasal carcinomas. STUDY DESIGN: Retrospective cohort. METHODS: Twenty-three nonsurgically and definitively treated patients diagnosed between July 1998 and February 2009 were analyzed. Patients with adenoid cystic carcinoma or adenocarcinoma were treated with photons and neutrons; the other histologies received photons alone. The vast majority received chemotherapy...
November 15, 2016: Laryngoscope
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