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https://www.readbyqxmd.com/read/28749621/ten-year-outcome-of-different-treatment-modalities-for-squamous-cell-carcinoma-of-oral-cavity
#1
Imjai Chitapanarux, Patrinee Traisathit, Nicha Komolmalai, Sompol Chuachamsai, Pichit Sittitrai, Tienchai Pattarasakulchai, Rak Tananuwat, Donyarat Boonlert, Patumrat Sripan, Anak Iamaroon
Objective: This study reports outcomes of squamous cell carcinoma of oral cavity (SCCOC) patients with different treatment modalities. Materials and Methods: We evaluated the treatment outcomes of 775 newly diagnosed SCCOC patients treated in our hospital between 2001 and 2010. Outcome data were obtained from the medical records. Survival rates were estimated by the Kaplan-Meyer method. Cox-proportional-hazard regression models were used to compare the risk of death among all risk factors. Results: The patients were divided into group 1) surgery ± adjuvant radiotherapy (RT) (n = 323) or group 2) RT ± chemotherapy (CT) for curative intent (n = 315) or group 3) RT/CT for palliative intent (n = 137)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749231/phase-%C3%A2-study-of-concurrent-chemoradiotherapy-with-a-modified-target-volumes-delineation-method-for-inoperable-esophageal-cancer-patients
#2
Wenyi Zhang, Huifang Li, Xingxing Chen, Meng Su, Ruifang Lin, Changlin Zou
OBJECTIVE: A Phase || study was designed to test the safety and efficacy of concurrent chemoradiotherapy with a modified target volumes delineation method for inoperable esophageal cancer patients. METHODS: All eligible patients were treated with concurrent chemoradiotherapy. The method of delineating target volume was as follow: Planning gross target volume (PGTV) was defined as the primary gross tumor volume (GTV-t) plus a 3 cm margin longitudinally and a 0...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749194/results-of-preoperative-chemoradiotherapy-for-patients-with-advanced-cancer-of-the-nasal-cavity-and-paranasal-sinuses
#3
Erik Fernström, Jan Nyman, Eva Hammerlid, Erik Holmberg, Hedda Haugen-Cange, Karin Petruson, Edvard Abel, Thomas Björk-Eriksson
OBJECTIVES: Curative treatment of nasal cavity and paranasal sinus cancer is challenging due to the proximity to critical anatomical structures. The purpose of this study was to analyze the impact of trimodality therapy with preoperative chemotherapy and reduced-dose radiotherapy followed by organ-preserving surgery for treating patients with nasal cavity and paranasal sinus cancer. METHODS: This retrospective study included all 156 patients diagnosed with sinonasal cancer in western Sweden between 1986 and 2009...
July 27, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28748803/serial-mri-scan-of-posterior-fossa-tumours-predict-patients-at-risk-of-developing-neurocognitive-impairment
#4
Ramadhan Othman, Kurdistan Gh Abdullah
Background: Brain tumours are the most common solid tumours in children. More than 50% of these tumours develop in the posterior cranial fossa. Long term survivors of posterior fossa tumours (PFT) suffer from neurocognitive and memory issues. We hypothesized that serial MRI scanning of brain would show differences in hippocampal and ACC volume change in PFT patients treated with and without chemo-radiotherapy. Material and Methods: Twelve patients (8 females and 4 males) underwent 76 serial MR imaging examinations before and during treatment for posterior fossa tumours...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748542/pediatric-intracerebral-histiocytic-sarcoma-with-rhabdoid-features-case-report-and-literature-review
#5
Young Hye Kim, Gie-Taek Yie, Na Rae Kim, In-Sang Jeon, Hyun Yee Cho, Jae Yeon Seok, Eung Yeop Kim, Kyu Chan Lee
A 16-year-old boy presented with marked weight loss, weakness of the left extremities and dizziness of 2 months duration and vomiting for 2 days. Brain MRI showed an approximately 6.5 × 5.3 cm-sized huge heterogeneous enhancing mass located in the corpus callosum, extending into the lateral ventricle. Open biopsy showed that the lesion consisted of lymphoplasmacytes and plump histiocytes with rhabdoid morphology, which were stained with S-100 protein, CD68 (KP1) and negative for CD1a. Histiocytic tumor was initially diagnosed...
July 27, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28748453/patterns-of-failure-of-diffuse-large-b%C3%A2-cell-lymphoma-patients-after-involved-site-radiotherapy
#6
Eva Holzhäuser, Maximilian Berlin, Daniel Wollschläger, Thomas Bezold, Arnulf Mayer, Georg Heß, Heinz Schmidberger
PURPOSE: Radiotherapy (RT) in combination with chemoimmunotherapy is highly efficient in the treatment of diffuse large B‑cell lymphoma (DLBCL). This retrospective analysis evaluated the efficacy of the treatment volume and the dose concept of involved-site RT (ISRT). PATIENTS AND METHODS: We identified 60 histologically confirmed stage I-IV DLBCL patients treated with multimodal cytotoxic chemoimmunotherapy and followed by consolidative ISRT from 2005-2015. Progression-free survival (PFS) and overall survival (OS) were estimated by Kaplan-Meier method...
July 26, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28748260/clinical-predictors-for-reactive-tube-feeding-in-patients-with-advanced-oropharynx-cancer-receiving-radiotherapy%C3%A2-%C3%A2-%C3%A2-chemotherapy
#7
Belinda Vangelov, Robert I Smee
Enteral feeding is often required for nutrition support in head and neck cancer patients when oral intake is inadequate. When to initiate the insertion of a feeding tube continues to be a debated issue in our institution. We investigated the use of reactive feeding tubes (RFTs) in patients with advanced stage oropharynx cancer (OPC). Data were retrospectively collected on 131 patients who had radiotherapy (RT) ± chemotherapy from 2005 to 2015. Predictors for RFT insertion were investigated. Weight loss during RT was compared between those with RFT versus prophylactic tubes (PFTs) versus no tube, and survival outcomes evaluated...
July 26, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28748189/apples-and-pears-a-comparison-of-two-sources-of-national-lung-cancer-audit-data-in-england
#8
Aamir Khakwani, Ruth H Jack, Sally Vernon, Rosie Dickinson, Natasha Wood, Susan Harden, Paul Beckett, Ian Woolhouse, Richard B Hubbard
In 2014, the method of data collection from NHS trusts in England for the National Lung Cancer Audit (NLCA) was changed from a bespoke dataset called LUCADA (Lung Cancer Data). Under the new contract, data are submitted via the Cancer Outcome and Service Dataset (COSD) system and linked additional cancer registry datasets. In 2014, trusts were given opportunity to submit LUCADA data as well as registry data. 132 NHS trusts submitted LUCADA data, and all 151 trusts submitted COSD data. This transitional year therefore provided the opportunity to compare both datasets for data completeness and reliability...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28747264/free-flap-surgical-correction-of-facial-deformity-after-anteromedial-maxillectomy
#9
Shunji Sarukawa, Hideaki Kamochi, Tadahide Noguchi, Ataru Sunaga, Hirokazu Uda, Yoshiyuki Mori, Hiroshi Nishino, Kotaro Yoshimura
Anteromedial maxillectomy is typically performed in conjunction with low-dose radiotherapy and intraarterial chemotherapy. In doing so, the extent of surgical defects is reduced. However, nasal deviation and oral incompetence may ensue, due to cicatricial contracture of wounds, and may be distressing to these patients. Herein, we report a series of eight free perforator flap procedures (anterolateral thigh [ALT] flap, 6; thoracodorsal artery perforator [TAP] flap, 2) used to correct such deformities. The TAP flap was combined with scapular tip [ST] osseous flap in patients with added zygomatic prominence defects...
July 6, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28746702/identifying-an-optimal-adjuvant-radiotherapy-dose-for-extremity-and-trunk-merkel-cell-carcinoma-following-resection-an-analysis-of-the-national-cancer-database
#10
Sagar A Patel, Muhammad M Qureshi, Debjani Sahni, Minh Tam Truong
Importance: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine neoplasm with a high risk of recurrence following resection. Despite a rising incidence over the past 3 decades, there is a paucity of prospective data owing to the rarity of this disease. Objective: To determine the optimal adjuvant radiation therapy (RT) dose following resection of localized MCC of the extremities or trunk. Design, Setting, and Participants: Using the National Cancer Database, a large national database consisting of a heterogeneous population and treatment settings, we retrospectively analyzed a cohort of 2093 patients 18 years or older with stage I to III MCC of the extremities and/or trunk treated with definitive surgery and adjuvant RT between 1998 and 2011...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28745793/hypoxia-associated-biomarkers-in-lung-cancer-an-update
#11
W Cui, F Wu, L Ma
The high incidence rates of lung cancer have resulted in multiple progressions in cancer research leading to the development of novel therapeutic strategies. The three main branches of cancer research where improvements are being made are surgery, chemotherapy, and radiotherapy. These research developments have significantly improved the survival rates of cancer patients as most of these therapeutic options target specific molecules involved in cancer progression and metastasis. Experimental research has successfully identified potentially important molecules responsible for cancer progression...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28745064/therapeutic-potential-of-investigational-chk-1-inhibitors-for-the-treatment-of-solid-tumors
#12
Hani M Babiker, Ali McBride, Laurence S Cooke, Daruka Mahadevan
For several decades' cancer treatment targeting DNA repair pathways incorporated both chemo- and radiotherapy only. However, over the last decade improved knowledge of DNA repair processes has paved the way for the development of novel targeted drugs abrogating DNA repair signaling. Checkpoint kinase inhibitors are exciting molecules and hold promise in the treatment of both solid and hematologic malignancies. Herein, we discuss preclinical and clinical studies with this class of molecules. Areas Covered: In this review, we discuss the role of check point kinase 1 (CHK-1) in DNA repair and provide a comprehensive summary of pre-clinical and early phase clinical trials with CHK-1 inhibitors...
July 26, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28744773/alveolar-soft-part-sarcoma-the-new-primary-intracranial-malignancy-a-case-report-and-review-of-the-literature
#13
REVIEW
Aditaya Kumar, B Alrohmain, W Taylor, P Bhattathiri
The purpose of this paper is to serve as a reference to aid in the management of this poorly understood intracranial malignancy. The authors report their experience treating the eighth ostensible case of a primary intracranial alveolar soft part sarcoma (ASPS). A 21-year-old man presented to hospital after collapsing. He gave a 1-year history of headache, a 2-month history of reduced visual acuity and on examination had left facial paraesthesia with left-sided incoordination. MRI of the brain revealed a large left posterior fossa mass...
July 26, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28743209/endoscopic-surgery-for-early-stage-nasopharyngeal-carcinoma-a-justified-initial-option
#14
Yan Huang, Qian-Hui Qiu
OBJECTIVES: To assess the prognosis of initial endoscopic surgery in T1N0M0 and T2N0M0 staged NPC patients. MATERIALS AND METHODS: Between 2002 and 2016, 10 previously untreated patients with T1N0M0 or T2N0M0 staged NPC volunteered to receive endoscopic surgery followed by four courses of TPF chemotherapy. EORTC QLQ-C30 and QLQ-H&N35 were used to evaluate the QOL after treatment. RESULTS: With the median follow-up of 30 months (range, 9 months to 128 months), the 24-month survival rate was 100% (6/6), 90% (9/10) patients were still alive and well, 20% (2/10) patients reported tumor recurrence...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28743162/contemporary-use-trends-and-survival-outcomes-in-patients-undergoing-radical-cystectomy-or-bladder-preservation-therapy-for-muscle-invasive-bladder-cancer
#15
David B Cahn, Elizabeth A Handorf, Eric M Ghiraldi, Benjamin T Ristau, Daniel M Geynisman, Thomas M Churilla, Eric M Horwitz, Mark L Sobczak, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Alexander Kutikov, Robert G Uzzo, Marc C Smaldone
BACKGROUND: The current study was performed to examine temporal trends and compare overall survival (OS) in patients undergoing radical cystectomy (RC) or bladder-preservation therapy (BPT) for muscle-invasive urothelial carcinoma of the bladder. METHODS: The authors reviewed the National Cancer Data Base to identify patients with AJCC stage II to III urothelial carcinoma of the bladder from 2004 through 2013. Patients receiving BPT were stratified as having received any external-beam radiotherapy (any XRT), definitive XRT (50-80 grays), and definitive XRT with chemotherapy (CRT)...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28742955/bayesian-one-step-ipd-network-meta-analysis-of-time-to-event-data-using-royston-parmar-models
#16
Suzanne C Freeman, James R Carpenter
Network meta-analysis (NMA) combines direct and indirect evidence from trials to calculate and rank treatment estimates. While modelling approaches for continuous and binary outcomes are relatively well developed, less work has been done with time-to-event outcomes. Such outcomes are usually analysed using Cox proportional hazard (PH) models. However, in oncology with longer follow-up time, and time-dependent effects of targeted treatments, this may no longer be appropriate. Network meta-analysis conducted in the Bayesian setting has been increasing in popularity...
July 25, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28742698/survival-benefit-of-neoadjuvant-treatment-in-clinical-t3n0m0-esophageal-cancer-results-from-a-retrospective-multicenter-european-study
#17
Styliani Mantziari, Caroline Gronnier, Florence Renaud, Alain Duhamel, Jérémie Théreaux, Cécile Brigand, Nicolas Carrère, Jérémie H Lefevre, Arnaud Pasquer, Nicolas Demartines, Denis Collet, Bernard Meunier, Christophe Mariette
BACKGROUND: Based on current guidelines, clinical T3N0M0 esophageal tumors may or may not receive neoadjuvant treatment, according to their perception as locally advanced (cT3) or early-stage tumors (stage II). The study aim was to assess the impact of neoadjuvant treatment upon survival for cT3N0M0 esophageal cancer patients, with subgroup analyses by histological type (squamous cell carcinoma vs adenocarcinoma) and type of neoadjuvant treatment (chemotherapy vs radiochemotherapy). METHODS: Data from patients operated on for esophageal cancer in 30 European centers were collected...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742542/clinical-practice-guidelines-for-cryosurgery-of-pancreatic-cancer-a-consensus-statement-from-the-china-cooperative-group-of-cryosurgery-on-pancreatic-cancer-international-society-of-cryosurgery-and-asian-society-of-cryosurgery
#18
Lihua He, Lizhi Niu, Nikolai N Korpan, Sajio Sumida, Yueyong Xiao, Jiaping Li, Barlian Sutedja, Youyong Lu, Jiansheng Zuo, Jianguo Liu, Kecheng Xu
Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8% to 10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. Cryosurgery was first used in 1984 for treatment of locally advanced PC and has since become a considerable treatment for most cases of unresectable PC. During the past decade, cryosurgery has been applied in some hospitals in China, and the newly developed technique of computed tomography- and/or ultrasound-guided percutaneous cryosurgery has shown better results than chemotherapy in cases of unresectable locally advanced PC, with the 1-year survival rate reported to be more than 50%...
July 24, 2017: Pancreas
https://www.readbyqxmd.com/read/28742399/nutrition-and-cancer-an-historical-perspective-the-past-present-and-future-of-nutrition-and-cancer-part-2-misunderstanding-and-ignoring-nutrition
#19
T Colin Campbell
The role that nutrition plays in cancer development and treatment has received considerable attention in recent decades, but it still engenders considerable controversy. Within the cancer research and especially the clinical community, for example, nutritional factors are considered to play, at best, a secondary role. The role of nutrition in cancer development was noted by authorities as far back as the early 1800s, generally under the theory that cancer is "constitutional" in its origin, implying a complex, multifactorial, multistage etiology...
July 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28741749/clinical-outcomes-after-local-field-conformal-reirradiation-of-patients-with-retropharyngeal-nodal-metastasis
#20
Courtney Pollard, Theresa P Nguyen, Sweet Ping Ng, Steven J Frank, Adam S Garden, Gary B Gunn, Clifton D Fuller, Beth M Beadle, William H Morrison, Shah J Shah, He Wang, Sam Tung, Conjun Wang, Lawrence D Ginsberg, Mark E Zafereo, Erich M Sturgis, Shirley Y Su, Ehab Y Hanna, David I Rosenthal, Jack Phan
BACKGROUND: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). METHODS: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. RESULTS: Thirteen patients (68%) had squamous cell carcinoma...
July 25, 2017: Head & Neck
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