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JOURNAL ARTICLE
Giovan Battista Ruffo, Rodolfo Russo, Tommaso Casini, Letizia Lombardini, Valeria Orecchia, Vincenzo Voi, Raffaella Origa, Gian Luca Forni, Monia Marchetti, Antonia Gigante, Giacomo Garibotto, Aurelio Maggio, Lucia De Franceschi
BACKGROUND: Hemoglobinopathies, among which thalassemic syndromes (transfusion-dependent and non-transfusion dependent thalassemias) and sickle cell disease (SCD), are the most widespread monogenic diseases worldwide. Hemoglobinopathies are endemic and spread-out all-over Italy, as result of internal and external migration flows. Nowadays, the increase therapeutic options associated to the general aging of patients with hemoglobinopathies related to the improvement in clinical management, contribute to the abnormalities in kidney function going from blood and urine test alterations to chronic kidney disease and end stage renal disease...
December 2, 2023: Journal of Clinical Medicine
#22
JOURNAL ARTICLE
Lijun Cai, Liyile Chen, Chengcheng Zhao, Guangtao Han, Qiuru Wang, Pengde Kang
OBJECTIVE: Preoperative anemia has been identified as a modifiable risk factor for multiple adverse outcomes. In real clinical practice, considering treatment of anemia would increase costs and delay surgery. Patients undergoing total hip arthroplasty (THA) with mild anemia are usually neglected and still underdiagnosed or inadequately treated. This study investigated the effects of preoperative borderline anemia and anemia intervention before THA on perioperative outcomes. METHODS: We screened 706 patients from those receiving THA at our hospital from January 2020 to January 2022, with 112 in the borderline anemia group and 594 in the non-anemia group...
December 4, 2023: Orthopaedic Surgery
#23
JOURNAL ARTICLE
Pierre-Marc Dion, Adam Greene, Andrew Beckett, Johannes von Vopelius-Feldt, Brodie Nolan
AIM: This study aimed to compare current out-of-hospital transfusion (OHT) protocols in Canadian civilian critical care transport organizations (CCTO) to expert recommendations and explore the variability and potential benefits of standardizing OHT practices across Canada. METHODS: A comprehensive cross-sectional study was conducted, encompassing all seven Canadian CCTOs that provide OHT. The study assessed adherence to expert recommendations and examined specific aspects of the transfusion process, such as indications for transfusion and cessation criteria...
December 2023: Resuscitation plus
#24
JOURNAL ARTICLE
Md Shahid Ansari, Dinesh Jain, Sandeep Budhiraja
BACKGROUND: Blood component transfusions are a common and often necessary medical practice during the epidemics of dengue. Transfusions are required for patients when they developed severe dengue fever or thrombocytopenia of 10×109 /L or less. This study therefore investigated the risk factors, performance and effectiveness of eight different machine-learning algorithms to predict blood component transfusion requirements in confirmed dengue cases admitted to hospital. The objective was to study the risk factors that can help to predict blood component transfusion needs...
November 17, 2023: Hematology, Transfusion and Cell Therapy
#25
JOURNAL ARTICLE
Na Li, Tho Pham, Calvino Cheng, Duncan C McElfresh, Ryan A Metcalf, W Alton Russell, Rebecca Birch, James T Yurkovich, Celina Montemayor-Garcia, William J Lane, Aaron A R Tobian, Nareg Roubinian, Jansen Seheult, Ruchika Goel
Use of data-driven methodologies in enhancing blood transfusion practices is rising, leveraging big data, machine learning, and optimization techniques to improve demand forecasting and supply chain management. This review used a narrative approach to identify, evaluate, and synthesize key studies that considered novel computational techniques for blood demand forecasting and inventory management through a search of PubMed and Web of Sciences databases for studies published from January 01, 2016, to March 30, 2023...
October 2, 2023: Transfusion Medicine Reviews
#26
REVIEW
H G Evans, M F Murphy, R Foy, P Dhiman, L Green, A Kotze, L von Neree, A J Palmer, S E Robinson, A Shah, F Tomini, S Trompeter, S Warnakulasuriya, W K Wong, S J Stanworth
No one doubts the significant variation in the practice of transfusion medicine. Common examples are the variability in transfusion thresholds and the use of tranexamic acid for surgery with likely high blood loss despite evidence-based standards. There is a long history of applying different strategies to address this variation, including education, clinical guidelines, audit and feedback, but the effectiveness and cost-effectiveness of these initiatives remains unclear. Advances in computerised decision support systems and the application of novel electronic capabilities offer alternative approaches to improving transfusion practice...
November 14, 2023: British Journal of Haematology
#27
JOURNAL ARTICLE
Zifeng Lian, Qiqi Lu, Bingquan Lin, Lingjian Chen, Peng Peng, Yanqiu Feng
BACKGROUND: The T2* value of interventricular septum is routinely reported for grading myocardial iron load in thalassemia major, and automatic segmentation of septum could shorten analysis time and reduce interobserver variability. PURPOSE: To develop a deep learning-based method for automatic septum segmentation from black-blood MR images for the myocardial T2* measurement of thalassemia patients. STUDY TYPE: Retrospective. POPULATION/SUBJECTS: One hundred forty-six transfusion-dependent thalassemia patients with cardiac MR examinations from two centers...
November 9, 2023: Journal of Magnetic Resonance Imaging: JMRI
#28
REVIEW
John C Wood
Thalassemias are among the most common hereditary diseases in the world because heterozygosity offers protection against malarial infection. Affected individuals have variable expression of alpha or beta chains that lead to their unbalanced utilization during hemoglobin formation, oxidative stress, and apoptosis of red cell precursors prior to maturation. Some individuals produce sufficient hemoglobin to survive but suffer the vascular stress imposed by chronic anemia and ineffective erythropoiesis. In other patients, mature red cell formation is insufficient, and chronic transfusions are required-suppressing anemia and ineffective erythropoiesis but at the expense of iron overload...
October 30, 2023: Annals of the New York Academy of Sciences
#29
Elizabeth P Crowe, Rida Hasan, Nabiha H Saifee, Sara Bakhtary, Jena L Miller, Juan M Gonzalez-Velez, Ruchika Goel
BACKGROUND: Intrauterine transfusion (IUT) is an invasive but critical and potentially life-saving intervention for severe fetal anemia with demonstrated improvement in outcomes. The fetus is vulnerable to hemodynamic alterations and transfusion-related adverse events; therefore, special consideration must be given to blood component selection and modification. There is widespread IUT practice variability, and existing guidance primarily relies on expert opinion and single center experiences...
October 27, 2023: Transfusion
#30
REVIEW
Goeto Dantes, Sarah Keene
Extracorporeal Membrane Oxygenation (ECMO) is an important tool for managing critically ill neonates. Bleeding and thrombotic complications are common and significant. An understanding of ECMO physiology, its interactions with the unique neonatal hemostatic pathways, and appreciation for the distinctive risks and benefits of neonatal transfusion as it applies to ECMO are required. Currently, there is variability regarding transfusion practices, related to changing norms and a lack of high-quality literature and trials...
December 2023: Clinics in Perinatology
#31
JOURNAL ARTICLE
Bodie Chislett, Ghadir Omran, Michael Harvey, Damien Bolton, Nathan Lawrentschuk
INTRODUCTION: Changing population demographics and the recent SARS-CoV-2 pandemic have forever changed healthcare, with increasing demands on straining systems. The economic cost is yet to be fully realised, with growing concerns around the current system's ability to accommodate the ageing comorbid population. Consequently, a paradigm shift has taken place in healthcare systems, prioritizing cost accountability. In the absence of established guidelines or robust literature, the use of laboratory tests postoperatively is often guided solely by clinician preference...
2023: Research and Reports in Urology
#32
JOURNAL ARTICLE
Senta Jorinde Raasveld, Sanne de Bruin, Merijn C Reuland, Claudia van den Oord, Jimmy Schenk, Cécile Aubron, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Marcella C A Müller, Thomas W L Scheeren, Zoe McQuilten, Andrew Flint, Tarikul Hamid, Michaël Piagnerelli, Tina Tomic Mahecic, Jan Benes, Lene Russell, Hernan Aguirre-Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V Llau, Manual Quintana-Diaz, Maria Cronhjort, Carmen A Pfortmueller, Nihan Yapici, Nathan D Nielsen, Akshay Shah, Harm-Jan de Grooth, Alexander P J Vlaar
IMPORTANCE: Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little is known about how these thresholds are incorporated into current practice. OBJECTIVE: To evaluate and describe ICU RBC transfusion practices worldwide. DESIGN, SETTING, AND PARTICIPANTS: International, prospective, cohort study that involved 3643 adult patients from 233 ICUs in 30 countries on 6 continents from March 2019 to October 2022 with data collection in prespecified weeks...
November 21, 2023: JAMA
#33
JOURNAL ARTICLE
Jiaqi Lou, Youfen Fan, Shengyong Cui, Neng Huang, Guoying Jin, Cui Chen, Chun Zhang, Jiliang Li
BACKGROUND: It is very common for burn patients to have hypothermia during escharectomy under general anesthesia, which increases the blood transfusion demand of burn patients, and may lead to blood coagulation disorder or even increase the mortality of patients. It is important to predict the occurrence of hypothermia in advance, but we lack a prognostic prediction model. Our study aimed to develop a nomogram to predict the incidence of hypothermia in adult burn patients undergoing escharectomy under general anesthesia to intervention the hazards associated with hypothermia early...
June 22, 2023: Burns
#34
JOURNAL ARTICLE
Tsz Wing Chu, Patrick Shannon, Tony Parks
INTRODUCTION: Skeletal growth arrest lines (GAL) are transverse lines of metaphyseal radiodensity accompanying episodic severe physiological stress. They are poorly described in fetal remains. MATERIALS AND METHODS: We searched our autopsy practice for instances of fetal GAL in post mortem radiology, and correlated them with long bone histology and placental pathology. We describe the appearance, distribution, and pathology of GAL in a cohort of fetal autopsies, and compare the placental pathology accompanying GAL to the placental pathology of asymmetrical growth restriction (AGR) in the same time period...
2024: Pediatric and Developmental Pathology
#35
JOURNAL ARTICLE
Matthew A C Zapf, Daniel V Fabbri, Jennifer Andrews, Gen Li, Robert E Freundlich, Samer Al-Droubi, Jonathan P Wanderer
STUDY OBJECTIVE: To develop an algorithm to predict intraoperative Red Blood Cell (RBC) transfusion from preoperative variables contained in the electronic medical record of our institution, with the goal of guiding type and screen ordering. DESIGN: Machine Learning model development on retrospective single-center hospital data. SETTING: Preoperative period and operating room. PATIENTS: The study included patients ≥18 years old who underwent surgery during 2019-2022 and excluded those who refused transfusion, underwent emergency surgery, or surgery for organ donation after cardiac or brain death...
September 27, 2023: Journal of Clinical Anesthesia
#36
JOURNAL ARTICLE
Neha Bhasin, Ravi Sarode
Acute chest syndrome (ACS) is the leading cause of mortality among individuals with sickle cell disease (SCD) accounting for 25% of all deaths. The etiologies and clinical manifestations of ACS are variable among children and adults, with a lack of clear risk stratification guidelines for the practicing clinician. In addition, the management of ACS is based on limited evidence and is currently guided primarily by expert opinion. This manuscript reviews the pathophysiology, risk factors, and current management strategies for ACS through a review of published data on this subject between 1988 and 2022...
September 3, 2023: Transfusion Medicine Reviews
#37
JOURNAL ARTICLE
Stephen D Waterford, Sari D Holmes, Clifford Edwin Fonner, Diane Alejo, Rawn Salenger, Nadia B Hensley, Michael Mazzeffi, Niv Ad
BACKGROUND: The decision to perform transfusion is common but varies among centers and surgeons. This study looked at variables associated with red blood cell (RBC) transfusion in a statewide database. The study aimed to understand discrepancies in transfusion rates among hospitals and to establish whether the hospital itself was a significant variable in transfusion, independent of variables known to affect transfusion in patients undergoing cardiac surgical procedures. METHODS: The Maryland Cardiac Surgery Quality Initiative is a consortium of centers in the state...
December 2023: Annals of Thoracic Surgery
#38
JOURNAL ARTICLE
Xiao Chen, Junpeng Pan, Yi Li, Ruixin Tang
OBJECTIVE: Anemia is one of the common adverse reactions after hip fracture surgery. The traditional method to solve anemia is allogeneic transfusion. However, the transfusion may lead to some complications such as septicemia and fever. So far, few studies have reported roles of machine learning in predicting whether blood transfusion is needed or not after hip fracture surgery. Therefore, the purpose of this study is to develop machine learning models to predict the likelihood of postoperative blood transfusion in patients undergoing hip fracture surgery...
September 21, 2023: Aging Clinical and Experimental Research
#39
JOURNAL ARTICLE
Luis R García-Chairez, Jose Ivan Robles-Torres, Roberto Alejandro Ríos-Palacios, Joana Valeria Enrriquez-Avila, Hector Erasmo Alcocer-Mey, Daniel Eduardo Cervantes-Miranda, Adrián Gutierrez-González
Background: Nephrectomy is the treatment for xanthogranulomatous pyelonephritis (XGP), but the surgery is often technically complex and associated with a high incidence of postoperative complications. The objective of this study was to determine factors that can predict the probability of major postoperative complications, admission to intensive care, or mortality. Methods: We conducted a retrospective observational study of patients with XGP who underwent simple nephrectomy in a tertiary care hospital in Mexico from 2015 to 2022...
2023: Ochsner Journal
#40
JOURNAL ARTICLE
Laura D Stephens, Jeremy W Jacobs, Brian D Adkins, Garrett S Booth
Published guidelines and clinical practices vary when defining indications for irradiation of blood components for the prevention of transfusion-associated graft-versus-host disease (TA-GVHD). This study assessed irradiation indication lists generated by multiple artificial intelligence (AI) programs, or chatbots, and compared them to 2020 British Society for Haematology (BSH) practice guidelines. Four chatbots (ChatGPT-3.5, ChatGPT-4, Bard, and Bing Chat) were prompted to list the indications for irradiation to prevent TA-GVHD...
July 2023: Transfusion Medicine Reviews
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