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https://www.readbyqxmd.com/read/28550166/lysine-acetylome-analysis-reveals-photosystem-ii-manganese-stabilizing-protein-acetylation-is-involved-in-negative-regulation-of-oxygen-evolution-in-model-cyanobacterium-synechococcus-sp-pcc-7002
#1
Zhuo Chen, Guiying Zhang, Mingkun Yang, Tao Li, Feng Ge, Jindong Zhao
Nϵ-Acetylation of lysine residues represents a frequently occurring post-translational modification widespread in bacteria that plays vital roles in regulating bacterial physiology and metabolism. However, the role of lysine acetylation in cyanobacteria remains unclear, presenting a hurdle to in-depth functional study of this post-translational modification. Here, we report the lysine acetylome of Synechococcus sp. PCC 7002 (hereafter Synechococcus) using peptide prefractionation, immunoaffinity enrichment, and coupling with high-precision liquid chromatography-tandem mass spectrometry analysis...
May 26, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28549949/recent-advancements-in-liposomes-targeting-strategies-to-cross-blood-brain-barrier-bbb-for-the-treatment-of-alzheimer-s-disease
#2
REVIEW
Mukta Agrawal, Ajazuddin, Dulal K Tripathi, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Spyridon Mourtas, Margareta Hammarlund-Udenaes, Amit Alexander
In this modern era, with the help of various advanced technologies, medical science has overcome most of the health-related issues successfully. Though, some diseases still remain unresolved due to various physiological barriers. One such condition is Alzheimer; a neurodegenerative disorder characterized by progressive memory impairment, behavioral abnormalities, mood swing and disturbed routine activities of the person suffering from. It is well known to all that the brain is entirely covered by a protective layer commonly known as blood brain barrier (BBB) which is responsible to maintain the homeostasis of brain by restricting the entry of toxic substances, drug molecules, various proteins and peptides, small hydrophilic molecules, large lipophilic substances and so many other peripheral components to protect the brain from any harmful stimuli...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28549921/two-representations-of-a-high-dimensional-perceptual-space
#3
Jonathan D Victor, Syed M Rizvi, Mary M Conte
A perceptual space is a mental workspace of points in a sensory domain that supports similarity and difference judgments and enables further processing such as classification and naming. Perceptual spaces are present across sensory modalities; examples include colors, faces, auditory textures, and odors. Color is perhaps the best-studied perceptual space, but it is atypical in two respects. First, the dimensions of color space are directly linked to the three cone absorption spectra, but the dimensions of generic perceptual spaces are not as readily traceable to single-neuron properties...
May 23, 2017: Vision Research
https://www.readbyqxmd.com/read/28547763/new-approaches-towards-the-understanding-of-integral-membrane-proteins-a-structural-perspective-on-g-protein-coupled-receptors
#4
REVIEW
Reinhard Grisshammer
Three-dimensional structure determination of integral membrane proteins has advanced in unprecedented detail our understanding of mechanistic events of how ion channels, transporters, receptors and enzymes function. This exciting progress required a tremendous amount of methods development, as exemplified here with G protein-coupled receptors (GPCRs): Optimizing the production of GPCRs in recombinant hosts; increasing the probability of crystal formation using high-affinity ligands, nanobodies, and minimal G proteins for co-crystallization, thus stabilizing receptors into one conformation; using the T4 lysozyme technology and other fusion partners to promote crystal contacts; advancing crystallization methods including the development of novel detergents, and miniaturization and automation of the lipidic cubic phase crystallization method; the concept of conformational thermostabilization of GPCRs; and developing microfocus X-ray synchrotron technologies to analyze small GPCR crystals...
May 25, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28546901/macrophages-as-effectors-of-acute-and-chronic-allograft-injury
#5
Yianzhu Liu, Malgorzata Kloc, Xian C Li
Organ transplants give a second chance of life to patients with end-stage organ failure. However, the immuno-logical barriers prove to be very challenging to overcome and graft rejection remains a major hurdle to long-term transplant survival. For decades, adaptive immunity has been the focus of studies, primarily based on the belief that T cells are necessary and sufficient for rejection. With better-developed immunosuppressive drugs and protocols that effectively control adaptive cells, innate immune cells have emerged as key effector cells in triggering graft injury and have therefore attracted much recent attention...
December 2016: Current Transplantation Reports
https://www.readbyqxmd.com/read/28545624/drug-development-for-heart-failure-with-preserved-ejection-fraction-what-pieces-are-missing-from-the-puzzle
#6
REVIEW
Michele Senni, Stephen J Greene, Javed Butler, Gregg C Fonarow, Mihai Gheorghiade
Despite the growing number of patients with heart failure with preserved ejection fraction (HFpEF) and event rates comparable with many cancers, there remain no pharmacologic agents definitively proven to improve patient outcomes. Although phase II trials have intermittently yielded encouraging results, none have translated into successful achievement of a phase III primary end point. Thus, because of the urgent need to discover proven therapies, it is prudent to reevaluate our current approach to HFpEF drug development...
June 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28541980/telemedicine-and-telehealth-the-potential-to-improve-rural-access-to-care
#7
Roxanne Nelson
Despite the promise of remote health care services, their operation faces hurdles.
June 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28540164/understanding-peroral-absorption-regulatory-aspects-and-contemporary-approaches-to-tackling-solubility-and-permeability-hurdles
#8
REVIEW
Prachi B Shekhawat, Varsha B Pokharkar
Oral drug absorption is a process influenced by the physicochemical and biopharmaceutical properties of the drug and its inter-relationship with the gastrointestinal tract. Drug solubility, dissolution and permeability across intestinal barrier are the key parameters controlling absorption. This review provides an overview of the factors that affect drug absorption and the classification of a drug on the basis of solubility and permeability. The biopharmaceutical classification system (BCS) was introduced in early 90׳s and is a regulatory tool used to predict bioavailability problems associated with a new entity, thereby helping in the development of a drug product...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28538922/the-national-policy-for-comprehensive-health-of-lesbians-gays-bisexuals-and-transgender-lgbt-and-access-to-the-sex-reassignment-process-in-the-brazilian-unified-health-system-sus-progress-and-challenges
#9
Gianna Schreiber Popadiuk, Daniel Canavese Oliveira, Marcos Claudio Signorelli
This study aimed to analyze how the Brazilian Ministry of Health (MS) is implementing the Sex Reassignment Process (SRP) in the Unified Health System (SUS), through research of public domain official documents, systematization of surgery's quantitative data and analysis of meeting reports of the LGBT Health Technical Committee (CTSLGBT) of the MS. We conducted exploratory research combining quantitative and qualitative methods, using as methodological basis the normative proposal of health programs and systems evaluation study...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28538311/intrasession-and-intersession-reliability-of-quadriceps-and-hamstrings-electromyography-during-a-standardized-hurdle-jump-test-with-single-leg-landing
#10
Mark T Cavanaugh, Saied Jalal Aboodarda, David G Behm
Cavanaugh, MT, Aboodarda, SJ, and Behm, DG. Intrasession and intersession reliability of quadriceps' and hamstrings' electromyography during a standardized hurdle jump test with single leg landing. J Strength Cond Res 31(6): 1601-1609, 2017-The objective of this study was to develop a standardized test to determine quadriceps and hamstrings muscle activation in a position emulating a noncontact anterior cruciate ligament injury. We assessed the intrasession and intersession reliability of surface electromyography (EMG) of the dominant leg after single-leg landing from a standardized hurdle jump...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538303/examining-fundamental-movement-competency-and-closed-chain-upper-extremity-dynamic-balance-in-swimmers
#11
Garrett S Bullock, Nate Brookreson, Amy M Knab, Robert J Butler
Bullock, GS, Brookreson, N, Knab, AM, and Butler, RJ. Examining fundamental movement competency and closed-chain upper-extremity dynamic balance in swimmers. J Strength Cond Res 31(6): 1544-1551, 2017-Abnormal fundamental movement patterns and upper-quarter dynamic balance are proposed mechanisms affecting athletic performance and injury risk. There are few studies investigating functional movement and closed-chain upper-extremity dynamic stability in swimmers. The purpose of this study was to determine differences in fundamental movement competency and closed-chain upper-extremity dynamic balance, using the Functional Movement Screen (FMS) and Upper-Quarter Y Balance Test (YBT-UQ), of high school (HS; n = 70) and collegiate (COL; n = 70) swimmers...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28535706/-contraceptive-care-for-adolescents-in-school-based-health-centers-is-essential
#12
Alison Moriarty Daley, E Carol Polifroni
Adolescents often face hurdles that may interfere with accessing contraceptive services. School-based health centers (SBHCs) are available to many teens in the United States; however, only half of SBHCs that serve adolescents are permitted to provide contraception. The aim of this descriptive phenomenological study was to describe the lived experience of nurse practitioners (NPs) providing contraceptive care to teens in SBHCs. Twelve NPs were interviewed and Colaizzi's method of descriptive phenomenological analysis was used to describe the lived experience of NPs providing contraceptive care to adolescents in SBHCs...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/28535106/value-tools-in-managed-care-decision-making-current-hurdles-and-future-opportunities
#13
Jeremy Schafer, Dominic Galante, Jason Shafrin
BACKGROUND: Organizations such as the National Comprehensive Cancer Network, American Society of Clinical Oncology, Institute for Clinical and Economic Review, and Memorial Sloan Kettering have created distinct tools to help different stakeholders assess the value of oncology treatments. However, the oncology value tools were not necessarily created for payers, and it is unclear whether payers are using these tools as part of their drug management process. OBJECTIVE: To understand what value tools payers are using in oncology management and what benefits and shortcomings the tools may have from the payer perspective...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28534866/-a-comparison-of-methods-for-modeling-factors-associated-with-hospital-admissions-in-incident-cases-of-heart-failure
#14
Francisco Javier Prado-Galbarro, Isabel Del-Cura-González, Sofía Garrido-Elustondo, Ana Estela Gamiño-Arroyo, Carlos Sánchez-Piedra, Antonio Sarriá Santamera
OBJECTIVE: Heart failure (HF) is an important public health problem due to its increasing prevalence, and the decompensation associated with hospital admission represents an increased risk of death. The objective of this study was to compare several methods to model the variable hospitalizations and to determine the effect of factors associated with hospital admissions in incident cases of HF. METHODS: Study of a retrospective cohort of patients with information extracted from electronic medical records of PC was performed...
May 24, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28533738/genetics-of-tinnitus-still-in-its-infancy
#15
REVIEW
Barbara Vona, Indrajit Nanda, Wafaa Shehata-Dieler, Thomas Haaf
Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general population. Despite this considerable prevalence, treatments for tinnitus are presently lacking. Tinnitus exhibits a diverse array of recognized risk factors and extreme clinical heterogeneity. Furthermore, it can involve an unknown number of auditory and non-auditory networks and molecular pathways. This complex combination has hampered advancements in the field. The identification of specific genetic factors has been at the forefront of several research investigations in the past decade...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28533168/prospects-for-therapeutic-mitochondrial-transplantation
#16
REVIEW
Jenna L Gollihue, Alexander G Rabchevsky
Mitochondrial dysfunction has been implicated in a multitude of diseases and pathological conditions- the organelles that are essential for life can also be major players in contributing to cell death and disease. Because mitochondria are so well established in our existence, being present in all cell types except for red blood cells and having the responsibility of providing most of our energy needs for survival, then dysfunctional mitochondria can elicit devastating cellular pathologies that can be widespread across the entire organism...
May 19, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28531355/flexible-multiferroic-bulk-heterojunction-with-giant-magnetoelectric-coupling-via-the-van-der-waals-epitaxy
#17
Ying-Hao Chu, Tahta Amrillah, Yugandhar Bitla, Kwangwoo Shin, Tiannan Yang, Ying-Hui Hsieh, Yu-You Chiou, Heng-Jui Liu, Thi Hien Do, Dong Su, Yi-Chun Chen, Shien-Uang Jen, Long-Qing Chen, Kee Hoon Kim, Jenh-Yih Juang
Magnetoelectric nanocomposites have been a topic of intense research due to their profound potential in the applications of electronic devices based on the spintronic technology. Nevertheless, in spite of significant progress made in the growth of high-quality nanocomposite thin films, the substrate clamping effect still remains as a major hurdle in realizing the ultimate magnetoelectric coupling. To overcome this obstacle, an alternative strategy of fabricating self-assembled ferroelectric-ferrimagnetic bulk heterojunction on flexible muscovite via the van der Waals epitaxy is adopted...
May 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28530417/effects-of-predictor-weighting-methods-on-incremental-validity
#18
Paul R Sackett, Jeffrey A Dahlke, Oren R Shewach, Nathan R Kuncel
It is common to add an additional predictor to a selection system with the goal of increasing criterion-related validity. Research on the incremental validity of a second predictor is generally based on forming a regression-weighted composite of the predictors. However, in practice predictors are commonly used in ways other than regression-weighted composites, and we examine the robustness of incremental validity findings to other ways of using predictors, namely, unit weighting and multiple hurdles. We show that there are settings in which the incremental value of a second predictor disappears, and can even produce lower validity than the first predictor alone, when these alternatives to regression weighting are used...
May 22, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28528952/an-overview-of-natural-renewable-bio-polymer-lignin-towards-nano-and-biotechnological-applications
#19
REVIEW
Selvaraj Mohana Roopan
Lignin were said to be major bio-polymer next to cellulose which is an abundant biopolymer. This type of lignin was mostly isolated from woods which were named after their physical, morphological appearances and majorly on extracting sources. Still now there are very few reports on isolation, identification of pure lignin and isolating pathways are also not well defined. Molecular weight of lignin varies from thousands to ten thousands which are not explored accurately. Even-though lignins were surrounded by these many hurdles it has various application studies which were studied and reported...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28528637/find-your-way-with-x-ray-using-microct-to-correlate-in-vivo-imaging-with-3d-electron-microscopy
#20
Matthia A Karreman, Bernhard Ruthensteiner, Luc Mercier, Nicole L Schieber, Gergely Solecki, Frank Winkler, Jacky G Goetz, Yannick Schwab
Combining in vivo imaging with electron microscopy (EM) uniquely allows monitoring rare and critical events in living tissue, followed by their high-resolution visualization in their native context. A major hurdle, however, is to keep track of the region of interest (ROI) when moving from intravital microscopy (IVM) to EM. Here, we present a workflow that relies on correlating IVM and microscopic X-ray computed tomography to predict the position of the ROI inside the EM-processed sample. The ROI can then be accurately and quickly targeted using ultramicrotomy and imaged using EM...
2017: Methods in Cell Biology
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