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https://www.readbyqxmd.com/read/28928866/ct-721-a-potent-bcr-abl-inhibitor-exhibits-excellent-in-vitro-and-in-vivo-efficacy-in-the-treatment-of-chronic-myeloid-leukemia
#1
Yinghui Sun, Na Zhao, Huan Wang, Qiong Wu, Yunqi Han, Qichao Liu, Mangang Wu, Yuliang Liu, Fansheng Kong, He Wang, Ying Sun, Deguang Sun, Lutao Jing, Guojing Tang, Yuandong Hu, Dengming Xiao, Hong Luo, Yongxin Han, Yong Peng
Kinase inhibitors that target Bcr-Abl are highly effective in the treatment of chronic myeloid leukemia (CML). However, these inhibitors are often invalidated due to the drug resistance. Therefore, the discovery and development of novel Bcr-Abl inhibitors is required to overwhelm the drug resistance in the treatment of CML resistant to the currently used first-line Bcr-Abl inhibitors. Herein we have described a newly developed Bcr-Abl inhibitor CT-721, which displayed potent inhibitory effects on wild-type and T315I mutant Bcr-Abl...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28927289/accounting-for-non-gaussian-sources-of-spatial-correlation-in-parametric-fmri-paradigms-i-revisiting-cluster-based-inferences
#2
Kaundinya Gopinath, Venkatagiri Krishnamurthy, K Sathian
In a recent study Eklund et al. (Eklund et al., 2016) employing resting state functional magnetic resonance imaging (rsfMRI) data as a surrogate for null fMRI datasets posited that cluster-wise family-wise error (FWE) rate corrected inferences made using parametric statistical methods in fMRI studies over the past two decades may have been invalid, particularly for cluster defining thresholds (CDTs) less stringent than p < 0.001; principally because the spatial autocorrelation functions (sACF) of fMRI data had been modeled incorrectly to follow a Gaussian form, whereas empirical data suggested otherwise (Eklund et al...
September 19, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28924696/guidelines-for-quality-control-of-pet-ct-scans-in-a-multicenter-clinical-study
#3
Ivalina Hristova, Ronald Boellaard, Paul Galette, Lalitha K Shankar, Yan Liu, Sigrid Stroobants, Otto S Hoekstra, Wim J G Oyen
To date, there is no published detailed checklist with parameters referencing the DICOM tag information with respect to the quality control (QC) of PET/CT scans. The aims of these guidelines are to provide the know-how for effectively controlling the quality of PET/CT scans in multicenter studies, to standardize the QC, to give sponsors and regulatory agencies a basis for justification of the data quality when using standardized uptake values as an imaging biomarker, to document the compliance with the imaging guidelines, to verify the per protocol population versus intent to treat population, and to safeguard the validity of multicenter study conclusions employing standardized uptake value (SUV) as an imaging biomarker which is paramount to the scientific community...
September 18, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28923291/use-of-prohibited-medication-a-potentially-overlooked-confounder-in-clinical-trials-omarigliptin-once-weekly-dpp-4-inhibitor-monotherapy-trial-in-18-to-45-year-olds
#4
Ira Gantz, Liubov Sokolova, Lokesh Jain, Carol Iredale, Edward A O'Neill, Ziwen Wei, Raymond Lam, Shailaja Suryawanshi, Keith D Kaufman, Samuel S Engel, Eseng Lai
PURPOSE: The objective of this clinical trial was to assess the efficacy and safety of omarigliptin monotherapy in young adult patients with type 2 diabetes mellitus (T2DM). Unexpected efficacy results in this trial led to a series of investigations that identified the use of prohibited medication by a substantial number of trial patients. METHODS: Patients with T2DM who were ≥18 to <45 years of age and either drug-naive or not on an antihyperglycemic agent for ≥12 weeks with inadequate glycemic control were randomized in a double-blind manner to receive omarigliptin 25 mg once weekly (n = 102) or placebo once weekly (n = 101) for 24 weeks...
September 15, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28919289/a-solid-criterion-based-on-strict-lmi-without-invoking-equality-constraint-for-stabilization-of-continuous-singular-systems
#5
Xuefeng Zhang, YangQuan Chen
The paper considers the stabilization issue of linear continuous singular systems by dealing with strict linear matrix inequalities (LMIs) without invoking equality constraint and proposes a complete and effective solved LMIs formulation. The criterion is necessary and sufficient condition and can be directly solved the feasible solutions with LMI toolbox and is much more tractable and reliable in numerical simulation than existing results, which involve positive semi-definite LMIs with equality constraints...
September 14, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28918069/studies-that-report-unexpected-positive-blood-cultures-for-lyme-borrelia-are-they-valid
#6
REVIEW
Gary P Wormser, Eugene D Shapiro, Franc Strle
Positive blood cultures for Lyme borrelia have been well documented in untreated patients with early Lyme disease. In this report we review the validity of three studies that reported the recovery of Borrelia burgdorferi sensu lato from the blood of a high proportion of patients for whom no evidence was presented, and no claim was made, that the patients had untreated early Lyme disease. In two of the studies the patients had been treated extensively with antibiotics for Lyme disease before the cultures were obtained...
July 29, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28916812/size-dependent-electrical-transport-properties-in-co-nanocluster-assembled-granular-films
#7
Q F Zhang, X Z Wang, L S Wang, H F Zheng, L Lin, J Xie, X Liu, Y L Qiu, Y Z Chen, D L Peng
A series of Co nanocluster-assembled films with cluster sizes ranging from 4.5 nm to 14.7 nm were prepared by the plasma-gas-condensation method. The size-dependent electrical transport properties were systematically investigated. Both of the longitudinal resistivity ([Formula: see text]) and saturated anomalous Hall resistivity ([Formula: see text]) continuously increased with the decrease of the cluster sizes (d). The [Formula: see text] firstly increased and then decreased with increasing the temperature for all samples, which could be well described by involving the thermally fluctuation-induced tunneling (FIT) process and scattering...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28906173/diagnosing-prosopagnosia-in-east-asian-individuals-norms-for-the-cambridge-face-memory-test-chinese
#8
Elinor McKone, Lulu Wan, Rachel Robbins, Kate Crookes, Jia Liu
The Cambridge Face Memory Test (CFMT) is widely accepted as providing a valid and reliable tool in diagnosing prosopagnosia (inability to recognize people's faces). Previously, large-sample norms have been available only for Caucasian-face versions, suitable for diagnosis in Caucasian observers. These are invalid for observers of different races due to potentially severe other-race effects. Here, we provide large-sample norms (N = 306) for East Asian observers on an Asian-face version (CFMT-Chinese). We also demonstrate methodological suitability of the CFMT-Chinese for prosopagnosia diagnosis (high internal reliability, approximately normal distribution, norm-score range sufficiently far above chance)...
September 14, 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/28904721/septal-alcoholization-in-hypertrophic-cardiomyopathy-about-11-cases
#9
Yibar Kambiré, Georges Rosario Christian Millogo, Claire Dauphin, Jean-René Lusson
Outcomes of septal alcoholization in hypertrophic obstructive cardiomyopathy are not enough studied in all centers. The purpose of this study was to determine the outcomes of septal alcoholization in hypertrophic obstructive cardiomyopathy in our hospital. A retrospective and prospective descriptive study focused on all patients aged at least 18 years treated by alcohol septal ablation between July 2005 and June 2010 in the cardiology unit of Clermont-Ferrand teaching Hospital. The inclusion criteria were, hypertrophic obstructive cardiomyopathy with left ventricular outflow tract obstruction ≥ 50 mmHg, symptomatic despite optimal medical therapy...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903832/validation-of-modifications-to-the-ansr-for-listeria-method-for-improved-internal-positive-control-performance
#10
Susan Alles, Evan Meister, Edan Hosking, Eric Tovar, Rebecca Shaulis, Mark Schonfeld, Lei Zhang, Lin Li, Preetha Biswas, Mark Mozola, Robert Donofrio
A study was conducted to validate a minor reagent formulation change to the ANSR for Listeria method, Performance Tested Method(SM) 101202. This change involves increasing the master mix volume prelyophilization by 40% and addition of salmon sperm DNA (nontarget DNA) to the master mix. These changes improve the robustness of the internal positive control response and reduce the possibility of obtaining invalid results due to weak-positive control curves. When three foods (hot dogs, Mexican-style cheese, and cantaloupe) and sponge samples taken from a stainless steel surface were tested, no significant differences in performance between the ANSR and U...
September 14, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28902122/on-p-values-and-effect-modification
#11
Martin Mayer
AIM: A crucial element of evidence-based healthcare is the sound understanding and use of statistics. As part of instilling sound statistical knowledge and practice, it seems useful to highlight instances of unsound statistical reasoning or practice, not merely in captious or vitriolic spirit, but rather, to use such error as a springboard for edification by giving tangibility to the concepts at hand and highlighting the importance of avoiding such error. This article aims to provide an instructive overview of two key statistical concepts: effect modification and P values...
September 8, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28895420/retrospective-analysis-of-20-cases-of-refractory-hodgkin-s-lymphoma
#12
H L Yang, Y Z Zhang, Y Z Jiang, X F Wang, Z Cao
We investigate the clinical characteristics, prognosis and treatment of relapsed and refractory Hodgkin's lymphoma. Twenty patients with relapsed and refractory Hodgkin lymphoma were treated by chemotherapy or autologous stem cell transplantation in our hospital from April 2006 to August 2012. The retrospective analysis of the records from the 20 patients reflected both 5-year overall survival (OS) and progression-free survival (PFS). The overall effectiveness was 80% for the 20 patients. The 5-year overall survival rate and 5-year progression-free survival rate were 73...
September 12, 2017: Neoplasma
https://www.readbyqxmd.com/read/28893471/illness-perceptions-and-negative-responses-from-medical-professionals-in-patients-with-fibromyalgia-association-with-patient-satisfaction-and-number-of-hospital-visits
#13
Mieko Homma, Hirono Ishikawa, Takahiro Kiuchi
OBJECTIVE: To examine whether illness perceptions among patients with fibromyalgia and negative responses from medical professionals correlate with their satisfaction with their physicians or with their number of hospital visits. METHODS: Questionnaires were sent by post to members of the Japan Fibromyalgia Support Association. Measures collected included, as independent variables, the Brief Illness Perception Questionnaire and the Illness Invalidation Inventory; and as outcomes, the Patient Satisfaction Consultation Questionnaire and the number of hospital visits...
August 30, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28882171/application-of-random-survival-forests-in-understanding-the-determinants-of-under-five-child-mortality-in-uganda-in-the-presence-of-covariates-that-satisfy-the-proportional-and-non-proportional-hazards-assumption
#14
Justine B Nasejje, Henry Mwambi
BACKGROUND: Uganda just like any other Sub-Saharan African country, has a high under-five child mortality rate. To inform policy on intervention strategies, sound statistical methods are required to critically identify factors strongly associated with under-five child mortality rates. The Cox proportional hazards model has been a common choice in analysing data to understand factors strongly associated with high child mortality rates taking age as the time-to-event variable. However, due to its restrictive proportional hazards (PH) assumption, some covariates of interest which do not satisfy the assumption are often excluded in the analysis to avoid mis-specifying the model...
September 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28882102/monte-carlo-simulation-based-estimation-for-the-minimum-mortality-temperature-in-temperature-mortality-association-study
#15
Whanhee Lee, Ho Kim, Sunghee Hwang, Antonella Zanobetti, Joel D Schwartz, Yeonseung Chung
BACKGROUND: Rich literature has reported that there exists a nonlinear association between temperature and mortality. One important feature in the temperature-mortality association is the minimum mortality temperature (MMT). The commonly used approach for estimating the MMT is to determine the MMT as the temperature at which mortality is minimized in the estimated temperature-mortality association curve. Also, an approximate bootstrap approach was proposed to calculate the standard errors and the confidence interval for the MMT...
September 7, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28881426/autoantibody-production-in-rheumatoid-arthritis-associated-with-alpha-1-antitrypsin-deficiency-is-complex-and-likely-driven-by-inflammation-and-neutrophil-dysfunction
#16
Cormac McCarthy, Carl Orr, Ursula Fearon, Douglas J Veale, Emer P Reeves, Noel G McElvaney
We thank Drs Hutchinson and Eggleton for their interest in our report and for raising some interesting points. While we believe there is some merit in the issues they raise, we do not believe these invalidate the data we have presented or the conclusions we made in our initial report. This article is protected by copyright. All rights reserved.
September 7, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28877963/the-effect-of-prior-knowledge-and-intelligibility-on-the-cortical-entrainment-response-to-speech
#17
Lucas Samuel Baltzell, Ramesh Srinivasan, Virginia M Richards
It has been suggested that cortical entrainment plays an important role in speech perception by helping to parse the acoustic stimulus into discrete linguistic units (Giraud & Poeppel, 2012). However, the question of whether the entrainment response to speech depends on the intelligibility of the stimulus remains open. Studies addressing this question of intelligibility have, for the most part, significantly distorted the acoustic properties of the stimulus to degrade the intelligibility of the speech stimulus, making it difficult to compare across "intelligible" and "unintelligible" conditions...
September 6, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28874717/correcting-for-photodestruction-in-super-resolution-optical-fluctuation-imaging
#18
Yves Peeters, Wim Vandenberg, Sam Duwé, Arno Bouwens, Tomáš Lukeš, Cyril Ruckebusch, Theo Lasser, Peter Dedecker
Super-resolution optical fluctuation imaging overcomes the diffraction limit by analyzing fluctuations in the fluorophore emission. A key assumption of the imaging is that the fluorophores are independent, though this is invalidated in the presence of photodestruction. In this work, we evaluate the effect of photodestruction on SOFI imaging using theoretical considerations and computer simulations. We find that photodestruction gives rise to an additional signal that does not present an easily interpretable view of the sample structure...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874122/doxycycline-treatment-in-dialysis-related-amyloidosis-discrepancy-between-antalgic-effect-and-inflammation-studied-with-fdg-positron-emission-tomography-a-case-report
#19
Giorgina Barbara Piccoli, Mammar Hachemi, Ida Molfino, Jean Philippe Coindre, Charles Boursot
BACKGROUND: No effective treatment is currently available and dialysis related amyloidosis continues to be invalidating in long-term dialysis patients. A recent case series reported reduction of osteoarticular pain on doxycycline treatment, extending the indications of this drug, used in other uncommon forms of amyloidosis, to dialysis patients. Explanations of the antalgic effect were the anti-inflammatory properties and anti-coiling effects of tetracycline. CASE PRESENTATION: Our report regards a 54-year-old woman, who was never transplanted and has been on hemodialysis and hemodiafiltration for overall 37 years, due to renal hypoplasia...
September 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28872343/in-the-spirit-of-full-disclosure-maternal-distress-emotion-validation-and-adolescent-disclosure-of-distressing-experiences
#20
Christina Gamache Martin, Hyoun K Kim, Jennifer J Freyd
The purpose of the current study was to investigate the dynamic process of disclosure within the adolescent-mother relationship by examining how maternal personal distress and validation of adolescent negative affect would be related to adolescent disclosure of a distressing experience for the first time. A community sample of 66 mothers and their adolescent children (M = 14.31 years, 58% female) participated. The adolescents disclosed an emotionally distressing experience to their mothers for the first time...
September 4, 2017: Emotion
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