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https://www.readbyqxmd.com/read/28228789/long-term-outcome-of-grade-iii-and-iv-chondral-injuries-of-the-knee-treated-with-steadman-microfracture-technique
#1
Marco Pellegrino, Ermanno Trinchese, Michele Bisaccia, Giuseppe Rinonapoli, Luigi Meccariello, Gabriele Falzarano, Antonio Medici, Luigi Piscitelli, Pellegrino Ferrara, Auro Caraffa
INTRODUCTION: The aim of our study is to demonstrate the effectiveness of Steadman microfracture technique in the management of high-grade chondral defects at the level of the knee by clinical follow-ups at eleven years. MATERIALS AND METHODS: This is a study conducted on fifteen patients suffering from Outerbridge grade III and IV chondral lesions of the knee, who underwent Steadman microfracture surgery between 2003 and 2004. Selective exclusion criteria to prevent that other treatments or comorbidities could invalidate the results were used...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28228145/donation-after-brain-circulation-determination-of-death
#2
Anne L Dalle Ave, James L Bernat
BACKGROUND: The fundamental determinant of death in donation after circulatory determination of death is the cessation of brain circulation and function. We therefore propose the term donation after brain circulation determination of death [DBCDD]. RESULTS: In DBCDD, death is determined when the cessation of circulatory function is permanent but before it is irreversible, consistent with medical standards of death determination outside the context of organ donation...
February 23, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28226474/estimation-of-arterio-venous-access-blood-flow-in-hemodialysis-patients-using-video-image-processing-technique
#3
Fansan Zhu, Schantel Williams, Hannah Putnam, Israel Campos, Jie Ma, Camille Johnson, Franz Kappel, Peter Kotanko, Fansan Zhu, Schantel Williams, Hannah Putnam, Israel Campos, Jie Ma, Camille Johnson, Franz Kappel, Peter Kotanko, Jie Ma, Israel Campos, Peter Kotanko, Schantel Williams, Franz Kappel, Fansan Zhu, Hannah Putnam, Camille Johnson
Assessment of arterio-venous fistula (AVF) blood flow (ABF) is vital in hemodialysis (HD) patients. Currently, no non-invasive and contact-free technique is available to accurately measure ABF in routine clinical practice. In this study, we developed a novel approach using video image processing (VIP) to measure the change in optic flow in the skin. We the tested the hypothesis that the change in optical flow, expressed as the change in pixels between consecutive frames, is related to ABF. We recorded AVF videos in 40 HD patients using a digital camera and processed them by VIP technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223147/comparative-performance-study-of-six-commercial-molecular-assays-for-rapid-detection-of-toxigenic-clostridium-difficile
#4
Yossi Paitan, Tamar Miller Roll, Amos Adler
OBJECTIVES: Rapid and accurate detection of C. difficile in stool impacts patient treatment and containment efforts. Detection of C. difficile toxin genes using nucleic acid amplification techniques (NAAT) is part of a multistep algorithm. Our objective was to directly compare the diagnostic accuracy and applicability of 6 commercial C. difficile NAAT assays. METHODS: In this study, 210 specimens were analysed in parallel by 6 commercial NAAT. Toxigenic culture was used as a reference method...
February 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28215965/menin-regulates-inhbb-expression-through-an-akt-ezh2-mediated-h3k27-histone-modification
#5
Samuele Gherardi, Doriane Ripoche, Ivan Mikaelian, Marie Chanal, Romain Teinturier, Delphine Goehrig, Martine Cordier-Bussat, Chang X Zhang, Ana Hennino, Philippe Bertolino
Although Men1 is a well-known tumour suppressor gene, little is known about the functions of Menin, the protein it encodes for. Since few years, numerous publications support a major role of Menin in the control of epigenetics gene regulation. While Menin interaction with MLL complex favours transcriptional activation of target genes through H3K4me3 marks, Menin also represses gene expression via mechanisms involving the Polycomb repressing complex (PRC). Interestingly, Ezh2, the PRC-methyltransferase that catalyses H3K27me3 repressive marks and Menin have been shown to co-occupy a large number of promoters...
February 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28214223/evaluation-of-a-field-test-for-antibodies-against-chlamydia-trachomatis-during-trachoma-surveillance-in-nepal
#6
Michelle J Sun, Andrea I Zambrano, Laura Dize, Beatriz Munoz, Sarah Gwyn, Sailesh Mishra, Diana L Martin, Shekhar Sharma, Sheila K West
PURPOSE: Testing for antibodies to Chlamydia trachomatis has potential as a surveillance tool. Our evaluation compares lateral flow assays (LFAs) during surveillance surveys in Nepal with Multiplex bead array (MBA). Fifty children were randomly sampled from each of 15 random clusters in two districts of Nepal. Finger prick blood samples were collected from 1509 children and tested onsite for anti-Pgp3 antibodies by LFA. The LFA was read at 30min as negative, positive, or invalid. Tests results were also rated as difficult to read ("equivocal")...
January 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28213117/involuntary-orienting-of-attention-to-a-sound-desynchronizes-the-occipital-alpha-rhythm-and-improves-visual-perception
#7
Wenfeng Feng, Viola S Störmer, Antigona Martinez, John J McDonald, Steven A Hillyard
Directing attention voluntarily to the location of a visual target results in an amplitude reduction (desynchronization) of the occipital alpha rhythm (8-14 Hz), which is predictive of improved perceptual processing of the target. Here we investigated whether modulations of the occipital alpha rhythm triggered by the involuntary orienting of attention to a salient but spatially non-predictive sound would similarly influence perception of a subsequent visual target. Target discrimination was more accurate when a sound preceded the target at the same location (validly cued trials) than when the sound was on the side opposite to the target (invalidly cued trials)...
February 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28208603/an-artificial-turf-based-surrogate-surface-collector-for-the-direct-measurement-of-atmospheric-mercury-dry-deposition
#8
Naima L Hall, Joseph Timothy Dvonch, Frank J Marsik, James A Barres, Matthew S Landis
This paper describes the development of a new artificial turf surrogate surface (ATSS) sampler for use in the measurement of mercury (Hg) dry deposition. In contrast to many existing surrogate surface designs, the ATSS utilizes a three-dimensional deposition surface that may more closely mimic the physical structure of many natural surfaces than traditional flat surrogate surface designs (water, filter, greased Mylar film). The ATSS has been designed to overcome several complicating factors that can impact the integrity of samples with other direct measurement approaches by providing a passive system which can be deployed for both short and extended periods of time (days to weeks), and is not contaminated by precipitation and/or invalidated by strong winds...
February 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28207288/equivalent-dynamic-models
#9
Peter C M Molenaar
Equivalences of two classes of dynamic models for weakly stationary multivariate time series are discussed: dynamic factor models and autoregressive models. It is shown that exploratory dynamic factor models can be rotated, yielding an infinite set of equivalent solutions for any observed series. It also is shown that dynamic factor models with lagged factor loadings are not equivalent to the currently popular state-space models, and that restriction of attention to the latter type of models may yield invalid results...
February 16, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28202742/invalidation-in-patients-with-rheumatic-diseases-clinical-and-psychological-framework
#10
Mariana Galante Santiago, Andréa Marques, Marianne Kool, Rinie Geenen, José António P da Silva
OBJECTIVE: The term "invalidation" refers to the patients' perception that their medical condition is not recognized by the social environment. Invalidation can be a major issue in patients' lives, adding a significant burden to symptoms and limitations while increasing the risk of physical and psychological disability. In this study in patients with rheumatic diseases, we investigated the relationship between invalidation and sociodemographic, clinical, psychological, and personality characteristics...
February 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28202710/practical-data-handling-pipeline-improves-performance-of-qpcr-based-circulating-mirna-measurements
#11
Maurice W J de Ronde, Jan M Ruijter, David Lanfear, Antoni Bayes-Genis, Maayke Kok, Esther Creemers, Yigal M Pinto, Sara-Joan Pinto-Sietsma
BACKGROUND: Since numerous miRNAs have been shown to be present in the circulation, these so-called circulating miRNAs have emerged as potential biomarkers for disease. However, results of qPCR studies on circulating miRNA biomarkers vary greatly and many experiments cannot be reproduced. Missing data in qPCR experiments often occur due to off-target amplification, non-analyzable qPCR curves and discordance between replicates. The low concentration of most miRNAs leads to most, but not all missing data...
February 15, 2017: RNA
https://www.readbyqxmd.com/read/28198748/time-trends-in-the-epidemiology-and-outcome-of-perianal-fistulizing-crohn-s-disease-in-a-population-based-cohort
#12
Kevin W A Göttgens, Steven F G Jeuring, Rosel Sturkenboom, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Daisy M A E Jonkers, Laurents P S Stassen, Ad A M Masclee, Marieke J Pierik, Stéphanie O Breukink
OBJECTIVE: Perianal disease is a debilitating condition that frequently occurs in Crohn's disease (CD) patients. It is currently unknown whether its incidence has changed in the era of frequent immunomodulator use and biological availability. We studied the incidence and outcome of perianal and rectovaginal fistulas over the past two decades in our population-based Inflammatory Bowel Disease South-Limburg cohort. PATIENTS AND METHODS: All 1162 CD patients registered in the Inflammatory Bowel Disease South-Limburg registry were included...
February 14, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28197865/revision-of-biliopancreatic-diversion-for-side-effects-or-insufficient-weight-loss-codification-of-a-new-procedure
#13
Valerio Ceriani, Ferdinando Pinna, Tiziana Lodi, Antonio E Pontiroli
PURPOSE: Addressing the problem of proctologic sequelae after Scopinaro's classical BPD, we elongated the common limb from 50 to 200 cm at the expense of the alimentary limb and simultaneously, with the aim of avoiding weight regain, reduced the gastric pouch from 500 to 40 ml. After increased experience with the new procedure, we observed a favourable tendency towards further weight loss. Thus, we subsequently extended the indication to the procedure to patients with unsatisfactory weight loss after Scopinaro's classical BPD (SBPD)...
February 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28197402/suicide-inhibition-of-cytochrome-p450-enzymes-by-cyclopropylamines-via-a-ring-opening-mechanism-proton-coupled-electron-transfer-makes-a-difference
#14
Xiaoqian Zhang, Xiao-Xi Li, Yufang Liu, Yong Wang
N-benzyl-N-cyclopropylamine (BCA) has been attracting great interests for decades for its partial suicide inactivation role to cytochrome P450 (P450) via a ring-opening mechanism besides acting as a role of normal substrates. Understanding the mechanism of such partial inactivation is vital to the clinical drug design. Thus, density functional theoretical (DFT) calculations were carried out on such P450-catalyzed reactions, not only on the metabolic pathway, but on the ring-opening inactivation one. Our theoretical results demonstrated that, in the metabolic pathway, besides the normal carbinolamine, an unexpected enamine was formed via the dual hydrogen abstraction (DHA) process, in which the competition between rotation of the H-abstracted substrate radical and the rotation of hydroxyl group of the protonated Cpd II moiety plays a significant role in product branch; In the inactivation pathway, the well-noted single electron transfer (SET) mechanism-involved process was invalidated for its high energy barrier, a proton-coupled electron transfer [PCET(ET)] mechanism plays a role...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28196856/vardenafil-reduces-macrophage-pro-inflammatory-overresponses-in-cystic-fibrosis-through-pde5-and-cftr-dependent-mechanisms
#15
Sabrina Noel, Nadtha Panin, Mathilde Beka, Barbara Dhooghe, Francois Huaux, Teresinha Leal
Chronic inflammation that progressively disrupts the lung tissue is a hallmark of Cystic Fibrosis (CF). In mice, vardenafil, an inhibitor of phosphodiesterase type 5 (PDE5), restores transepithelial ion transport and corrects mislocalization of the most common CF mutation, F508del-CFTR. It also reduces lung pro-inflammatory responses in mice and in patients with CF. To test the hypothesis that macrophages are target effector cells of the immunomodulatory effect of vardenafil, we isolated lung macrophages from mice homozygous for the F508del mutation or invalidated for the cftr gene and from their corresponding wild-type littermates...
February 14, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28196375/adding-temporally-localized-noise-can-enhance-the-contribution-of-target-knowledge-on-contrast-detection
#16
Daphné Silvestre, Patrick Cavanagh, Angelo Arleo, Rémy Allard
External noise paradigms are widely used to characterize sensitivity by comparing the effect of a variable on contrast threshold when it is limited by internal versus external noise. A basic assumption of external noise paradigms is that the processing properties are the same in low and high noise. However, recent studies (e.g., Allard & Cavanagh, 2011; Allard & Faubert, 2014b) suggest that this assumption could be violated when using spatiotemporally localized noise (i.e., appearing simultaneously and at the same location as the target) but not when using spatiotemporally extended noise (i...
February 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28195702/how-do-pseudo-capacitors-store-energy-theoretical-analysis-and-experimental-illustration
#17
Cyrille Costentin, Thomas R Porter, Jean-Michel Savéant
Batteries and electrochemical double layer charging capacitors are two classical means of storing electrical energy. These two types of charge storage can be unambiguously distinguished from one another by the shape and scan rate dependence of their cyclic current-potential (CV) responses. The former shows peak-shaped current-potential responses, proportional to the scan rate, v, or to v1/2 whereas the latter displays a quasi-rectangular response proportional to the scan rate. On the contrary, the notion of pseudo-capacitance, popularized in the 1980-90s for metal oxide systems, has been used to describe a charge storage process that is Faradaic in nature yet displays capacitive CV signatures...
February 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28192502/theta-burst-transcranial-magnetic-stimulation-to-the-prefrontal-or-parietal-cortex-does-not-impair-metacognitive-visual-awareness
#18
Daniel Bor, David J Schwartzman, Adam B Barrett, Anil K Seth
Neuroimaging studies commonly associate dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex with conscious perception. However, such studies only investigate correlation, rather than causation. In addition, many studies conflate objective performance with subjective awareness. In an influential recent paper, Rounis and colleagues addressed these issues by showing that continuous theta burst transcranial magnetic stimulation (cTBS) applied to the DLPFC impaired metacognitive (subjective) awareness for a perceptual task, while objective performance was kept constant...
2017: PloS One
https://www.readbyqxmd.com/read/28187024/residual-symptom-analysis-after-the-subtotal-anterior-and-middle-scalenectomy-for-disputed-thoracic-outlet-syndrome-comparison-between-surgical-and-untreated-patients
#19
Xu Gong, Zhen Min Jiang, Lai Jin Lu
OBJECTIVE: There are significant differences in the results on disputed thoracic outlet syndrome (TOS) surgery, which reflect that not all patients with disputed TOS are amenable to surgery. It is necessary to find out appropriate indicators for screening of patients who are suitable for surgery. Pain and paresthesia are 2 prominent symptoms of disputed TOS. The purpose of this study was to identify which symptoms could be removed by surgery. METHODS: Data for all patients with disputed TOS who were admitted and prepared for surgical treatment between July 2008 and April 2012 were collected...
February 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28185894/trpc1-and-trpc4-channels-functionally-interact-with-stim1l-to-promote-myogenesis-and-maintain-fast-repetitive-ca-2-release-in-human-myotubes
#20
Fabrice Antigny, Jessica Sabourin, Sophie Saüc, Laurent Bernheim, Stéphane Koenig, Maud Frieden
STIM1 and Orai1 are essential players of store-operated Ca(2+) entry (SOCE) in human skeletal muscle cells and are required for adult muscle differentiation. Besides these two proteins, TRPC (transient receptor potential canonical) channels and STIM1L (a longer STIM1 isoform) are also present on muscle cells. In the present study, we assessed the role of TRPC1, TRPC4 and STIM1L in SOCE, in the maintenance of repetitive Ca(2+) transients and in muscle differentiation. Knockdown of TRPC1 and TRPC4 reduced SOCE by about 50% and significantly delayed the onset of Ca(2+) entry, both effects similar to STIM1L invalidation...
February 6, 2017: Biochimica et Biophysica Acta
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