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https://www.readbyqxmd.com/read/28086909/fast-detection-and-data-compensation-for-electrodes-disconnection-in-long-term-monitoring-of-dynamic-brain-electrical-impedance-tomography
#1
Ge Zhang, Meng Dai, Lin Yang, Weichen Li, Haoting Li, Canhua Xu, Xuetao Shi, Xiuzhen Dong, Feng Fu
BACKGROUND: Electrode disconnection is a common occurrence during long-term monitoring of brain electrical impedance tomography (EIT) in clinical settings. The data acquisition system suffers remarkable data loss which results in image reconstruction failure. The aim of this study was to: (1) detect disconnected electrodes and (2) account for invalid data. METHODS: Weighted correlation coefficient for each electrode was calculated based on the measurement differences between well-connected and disconnected electrodes...
January 7, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28081452/differential-white-matter-involvement-associated-with-distinct-visuospatial-deficits-after-right-hemisphere-stroke
#2
Alex R Carter, Mark P McAvoy, Joshua S Siegel, Xin Hong, Serguei V Astafiev, Jennifer Rengachary, Kristi Zinn, Nicholas V Metcalf, Gordon L Shulman, Maurizio Corbetta
Visuospatial attention depends on the integration of multiple processes, and people with right hemisphere lesions after a stroke may exhibit severe or no visuospatial deficits. The anatomy of core components of visuospatial attention is an area of intense interest. Here we examine the relationship between the disruption of core components of attention and lesion distribution in a heterogeneous group (N = 70) of patients with right hemisphere strokes regardless of the presence of clinical neglect. Deficits of lateralized spatial orienting, measured as the difference in reaction times for responding to visual targets in the contralesional or ipsilesional visual field, and deficits in re-orienting attention, as measured by the difference in reaction times for invalidly versus validly cued targets, were measured using a computerized spatial orienting task...
December 20, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28081227/diagnostic-accuracy-of-genexpert-mtb-rif-assay-in-comparison-to-conventional-drug-susceptibility-testing-method-for-the-diagnosis-of-multidrug-resistant-tuberculosis
#3
Pratikshya Pandey, Narayan Dutt Pant, Komal Raj Rijal, Bhawana Shrestha, Sirita Kattel, Megha Raj Banjara, Bhagwan Maharjan, Rajendra Kc
Xpert MTB/RIF assay is regarded as a great achievement of modern medicine for the rapid diagnosis of multidrug-resistant tuberculosis (MDR-TB). The main purpose of this study was to determine the performance of Xpert MTB/RIF assay compared to conventional drug susceptibility testing (DST) method for the diagnosis of MDR-TB. A comparative cross sectional study was carried out at German-Nepal Tuberculosis Project, Kathmandu, Nepal, from April 2014 to September 2014. A total of 88 culture positive clinical samples (83 pulmonary and 5 extra-pulmonary) received during the study period were analyzed for detection of multidrug-resistant tuberculosis by both GeneXpert MTB/RIF assay and conventional DST method...
2017: PloS One
https://www.readbyqxmd.com/read/28074653/the-essential-medicinal-chemistry-of-curcumin
#4
Kathryn M Nelson, Jayme L Dahlin, Jonathan Bisson, James Graham, Guido F Pauli, Michael A Walters
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful...
January 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28070842/diagnostic-imaging-and-spending-review-extreme-problems-call-for-extreme-measures
#5
Anna Micaela Ciarrapico, Rossana Ugenti, Lidia Di Minco, Elisabetta Santori, Simone Altobelli, Irene Coco, Silvia D'Onofrio, Giovanni Simonetti
The number of diagnostic imaging tests has increased dramatically over the past decade and about 5 billion diagnostic examinations are performed worldwide each year. According to Health Ministry, Italy, is in second place for the number of CT and MR tests per thousand inhabitants in 2014 with a score of 83.3 (only Germany has a higher score, 95.2) that is a long way off from the European average of 46.5. It has also the highest ratio of magnetic resonances per person with 24,6 machines per million inhabitants, followed only by Greece and Finland...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28069345/patients-perspectives-on-quality-of-life-after-burn
#6
Marianne B Kool, Rinie Geenen, Marthe R Egberts, Hendriët Wanders, Nancy E Van Loey
BACKGROUND: The concept quality of life (QOL) refers to both health-related outcomes and one's skills to reach these outcomes, which is not yet incorporated in the burn-related QOL conceptualisation. The aim of this study was to obtain a comprehensive overview of relevant burn-specific domains of QOL from the patient's perspective and to determine its hierarchical structure. METHODS: Concept mapping was used comprising a focus group (n=6), interviews (n=25), and a card-sorting task (n=24) in burn survivors...
January 6, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28067633/single-mode-tuning-of-the-plasmon-resonance-in-high-density-pillar-arrays
#7
Matthew David Arnold
The Maxwell-Garnett (MG) effective medium model has a pure resonance controlled by volume fraction f, but is usually invalid at high density. I present special 2D structures that match quasistatic MG over the entire range 0<f<1, in several regular and semi-regular arrays, expanding the applicability of MG. A key insight is the direct relationship between optimal surface polarization and surface position. Electrodynamic calculations underline the effect of constituent permittivity on spatial dispersion and required sizes for quasistatic response in various materials...
January 9, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28065953/self-evaluation-of-ethical-review-committees-functioning-at-foundation-university-medical-college-fumc-through-structured-constitution-practice-outcome-cpo-assessment-model
#8
Sadia Ahsin, Gul E Naghma Saeed
OBJECTIVE: To assess the operational efficiency of the ethical review committee of a medical college. METHODS: This study was conducted at the Foundation University Medical College, Islamabad, Pakistan, from 2012 to 2014. On the basis of literature review, methods for assessment of various features of ethical review committee were studied. A constitution-practice-outcome measurement model for evaluation of ethical review committee assessment process was developed...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28062279/nitric-oxide-induced-synthesis-of-hydrogen-sulfide-alleviates-osmotic-stress-in-wheat-seedlings-through-sustaining-antioxidant-enzymes-osmolyte-accumulation-and-cysteine-homeostasis
#9
M Nasir Khan, M Mobin, Zahid Khorshid Abbas, Manzer H Siddiqui
Nitric oxide (NO) and hydrogen sulfide (H2S) have been shown to act as signaling molecules in various physiological processes, play significant roles in plant cellular processes, and also mediate responses to both biotic and abiotic stresses in plants. The present investigation was carried out to test the effect of exogenous NO on endogenous synthesis of H2S in osmotic-stressed wheat (Triticum aestivum L.) seedlings. The results show that application of NO to wheat seedlings, suffered from PEG8000-induced osmotic stress, considerably enhanced the activities of H2S-synthesizing enzymes l-cysteine desulfhydrase (LCD) and d-cysteine desulfhydrase (DCD) leading to enhanced level of endogenous H2S content...
January 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28060705/cross-spectrum-pm-noise-measurements-thermal-energy-and-metamaterial-filters
#10
Yannick Gruson, Vincent Giordano, Ulrich L Rohde, Ajay Kumar Poddar, Enrico Rubiola
Virtually all commercial instruments for the measurement of the oscillator PM noise make use of the Cross Spectrum method (arXiv:1004.5539 [physics.ins-det], 2010). High sensitivity is achieved by correlation and averaging on two equal channels which measure the same input, and reject the background of the instrument. We show that a systematic error is always present if the thermal energy of the input power splitter is not accounted for. Such error can result in noise under estimation up to a few dB in the lowest-noise quartz oscillators, and in an invalid measurement in the case of cryogenic oscillators...
January 4, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28057127/-prevalence-and-associated-factors-of-female-urinary-incontinence-in-hebei-province
#11
Y Jiang, L Yan, F D Du, P T Zheng, L Zhang, L Jiang, X H Huang
Objective: To estimate the prevalence and associated factors of adult female urinary incontinence in Hebei province. Methods: Stratified and multistage sampling method was used, between January 2016 to May 2016, to investigate the target population in Hebei province. While, logistic regression was used to analyse datas. Results: A population-based survey was conducted in 2 450 women in Hebei province, there were 2 408 effective questionnaires after deleting 48 invalid questionnaires. According to the results, the average age of subjects was (56±15) years old, and the urinary incontinence prevalence of adult female in Hebei province was 27...
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28055033/an-electrical-load-measurements-dataset-of-united-kingdom-households-from-a-two-year-longitudinal-study
#12
David Murray, Lina Stankovic, Vladimir Stankovic
Smart meter roll-outs provide easy access to granular meter measurements, enabling advanced energy services, ranging from demand response measures, tailored energy feedback and smart home/building automation. To design such services, train and validate models, access to data that resembles what is expected of smart meters, collected in a real-world setting, is necessary. The REFIT electrical load measurements dataset described in this paper includes whole house aggregate loads and nine individual appliance measurements at 8-second intervals per house, collected continuously over a period of two years from 20 houses...
January 5, 2017: Scientific Data
https://www.readbyqxmd.com/read/28048883/su-g-206-14-individual-dose-alert-thresholds-for-abdominal-ct-protocols-due-to-statistical-independence-of-dose-distributions
#13
B K Stewart
PURPOSE: To determine whether a single dose management system alert threshold will suffice for the 34 abdomen protocols on our institution's CT scanners, or if these alert thresholds should be set per protocol. Parametric statistical analysis is ideally valid only for distributions demonstrating: (1) normality (2) homogeneity of variance (3) interval scale and (4) independence. Dose distributions are notoriously non-normal and thus nonparametric statistical analysis is typically required...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047553/su-f-t-686-considerations-about-dose-protraction-factor-in-tcp-calculations-for-prostate-vmat-treatments
#14
F Clemente, C Perez-Vara, M Clavo
PURPOSE: Dose protraction factor should be considered in order to model the TCP calculations. Nevertheless, this study describes a brief discussion showing that the lack of its inclusion should not invalidate these calculations for prostate VMAT treatments. METHODS: Dose protraction factor (G) modifies the quadratic term of the linear-quadratic expression in order to take into account the sublethal damage repair of protracting the dose delivery. If the delivery takes a short time (instantaneous), G = 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047099/we-de-207b-05-measuring-spatial-resolution-in-digital-breast-tomosynthesis-update-of-aapm-task-group-245
#15
D A Scaduto, M Goodsitt, H-P Chan, H Olafsdottir, M Das, E Fredenberg, W Geiser, D Goodenough, P Heid, Y-H Hu, B Liu, J Mainprize, I Reiser, R Van Engen, V Varchena, S Vecchio, S Glick, W Zhao
PURPOSE: Spatial resolution in digital breast tomosynthesis (DBT) is affected by inherent/binned detector resolution, oblique entry of x-rays, and focal spot size/motion; the limited angular range further limits spatial resolution in the depth-direction. While DBT is being widely adopted clinically, imaging performance metrics and quality control protocols have not been standardized. AAPM Task Group 245 on Tomosynthesis Quality Control has been formed to address this deficiency. METHODS: Methods of measuring spatial resolution are evaluated using two prototype quality control phantoms for DBT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046517/we-h-207a-03-the-universality-of-the-lognormal-behavior-of-f-18-flt-pet-suv-measurements
#16
M Scarpelli, J Eickhoff, S Perlman, R Jeraj
PURPOSE: Log transforming [F-18]FDG PET standardized uptake values (SUVs) has been shown to lead to normal SUV distributions, which allows utilization of powerful parametric statistical models. This study identified the optimal transformation leading to normally distributed [F-18]FLT PET SUVs from solid tumors and offers an example of how normal distributions permits analysis of non-independent/correlated measurements. METHODS: Forty patients with various metastatic diseases underwent up to six FLT PET/CT scans during treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039602/residential-segregation-and-racial-cancer-disparities-a-systematic-review
#17
Hope Landrine, Irma Corral, Joseph G L Lee, Jimmy T Efird, Marla B Hall, Jukelia J Bess
BACKGROUND: This paper provides the first review of empirical studies of segregation and black-white cancer disparities. METHODS: We searched all years of PubMed (through May 2016) using these terms: racial segregation, residential segregation, neighborhood racial composition (first terms) and (second terms) cancer incidence, mortality, survival, stage at diagnosis, screening. The 17 (of 668) articles that measured both segregation and a cancer outcome were retained...
December 30, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28036214/diffusiophoretic-focusing-of-suspended-colloids
#18
Nan Shi, Rodrigo Nery-Azevedo, Amr I Abdel-Fattah, Todd M Squires
Using a microfluidic system to impose and maintain controlled, steady-state multicomponent pH and electrolyte gradients, we present systems where the diffusiophoretic migration of suspended colloids leads them to focus at a particular position, even in steady-state gradients. We show that naively superpositing effects of each gradient may seem conceptually and qualitatively reasonable, yet is invalid due to the coupled transport of these multicomponent electrolytes. In fact, reformulating the classic theories in terms of the flux of each species (rather than local gradients) reveals rather stringent conditions that are necessary for diffusiophoretic focusing in steady gradients...
December 16, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/28032009/assessment-of-feigned-cognitive-impairment-in-severe-traumatic-brain-injury-patients-with-the-forced-choice-graphics-memory-test
#19
Zilong Liu, Juan Dong, Xiaohong Zhao, Xiaorui Chen, Sara M Lippa, Jerome S Caroselli, Xiang Fang
INTRODUCTION: The Forced-choice Graphics Memory Test (FGMT) is a newly developed measure to assess feigned cognitive impairment. This study investigated the ability and reliability of FGMT for identification of malingering in patients with traumatic brain injury (TBI). METHODS: The FGMT was administered to 40 healthy volunteers instructed to respond validly (Healthy Control, H-C), 40 healthy volunteers instructed to feign cognitive impairment (Healthy Malingering, H-M), 40 severe TBI patients who responded validly (TBI control, TBI-C), and 30 severe TBI patients who evidenced invalid performance (TBI malingering, TBI-M)...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28027883/role-of-the-h-bond-between-l53-and-t56-for-aquaporin-4-epitope-in-neuromyelitis-optica
#20
Francesco Pisani, Laura Simone, Concetta Domenica Gargano, Manuela De Bellis, Antonio Cibelli, Maria Grazia Mola, Giacomo Catacchio, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchia
Aquaporin-4 (AQP4) is the CNS water channel organized into well-ordered protein aggregates called Orthogonal Arrays of Particles (OAPs). Neuromyelitis Optica (NMO) is an autoimmune disease caused by anti-OAP autoantibodies (AQP4-IgG). Molecular Dynamics (MD) simulations have identified an H-bond between L53 and T56 as the key for AQP4 epitope and therefore of potential interest for drug design in NMO field. In the present study, we have experimentally tested this MD-prediction using the classic mutagenesis approach...
December 24, 2016: Biochimica et Biophysica Acta
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