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Jeroen G V Habets, Roel H L Haeren, Suen A N Lie, Noel J C Bauer, Jim T A Dings
BACKGROUND: We present a case of orbital compartment syndrome (OCS) leading to monocular irreversible blindness following a pterional craniotomy for clipping of an anterior communicating artery (ACoA) aneurysm. OCS is an uncommon but vision-threatening entity requiring urgent decompression to reduce the risk of permanent visual loss. Iatrogenic orbital roof defects are a common finding following pterional craniotomies. However, complications related to these defects are rarely reported...
March 12, 2018: World Neurosurgery
Patrik Wolle, Matthias P Müller, Daniel Rauh
The examination of three-dimensional structural models in scientific publications allows the reader to validate or invalidate conclusions drawn by the authors. However, either due to a (temporary) lack of access to proper visualization software or a lack of proficiency, this information is not necessarily available to every reader. As the digital revolution is quickly progressing, technologies have become widely available that overcome the limitations and offer to all the opportunity to appreciate models not only in 2D, but also in 3D...
March 16, 2018: ACS Chemical Biology
Anna Lang, Tilmann Betsch
We investigated whether children prefer feedback over stated probabilistic information in decision making. 6-year-olds', 9-year-olds', and adults' making was examined in an environment where probabilistic information about choice outcome had to be actively searched ( N = 166) or was available without search ( N = 183). Probabilistic information was provided before choices as predictions of cues differing in validity. The presence of outcome feedback was varied. 6-year-olds, but not 9-year-olds were over-responsive to negative outcomes leading to choices biased by recent feedback...
2018: Frontiers in Psychology
Elizabeth G Raymond, Tara Shochet, Hillary Bracken
OBJECTIVES: To summarize data on the accuracy and acceptability of a strategy for identifying ongoing pregnancy after medical abortion treatment using a low-sensitivity pregnancy test (LSPT). STUDY DESIGN: We searched PubMed to identify studies that evaluated the use of a single post-treatment LSPT for detection of ongoing pregnancy after treatment with mifepristone and misoprostol. We extracted, assessed, and summarized data from each study. RESULTS: We found 10 studies that evaluated 6 LSPTs with human chorionic gonadotropin detection thresholds of 1000, 1500, or 2000 mIU/ml...
March 10, 2018: Contraception
Samuel Romero, Amparo Sempere, Inés Gómez-Seguí, Elena Román, Andrés Moret, Rosa Jannone, Iván Moreno, Santiago Mendizábal, Jordi Espí, Ana Peris, Rafael Carbonell, José Cervera, Javier Pemán, Santiago Bonanad, Javier de la Rubia, Isidro Jarque
BACKGROUND AND AIM: The term thrombotic microangiopathy (TMA) involves a heterogeneous group of diseases that can be overwhelming or invalidating, with an acute development, characterised by microangiopathic haemolytic anaemia and thrombocytopaenia. Its management during its initial hours is essential to improving the prognostic of these patients. The aim of this review is to give recommendations about the optimisation of TMA initial treatment and to accelerate the aetiological diagnosis...
March 10, 2018: Medicina Clínica
Christopher A Abeare, Isabelle Messa, Brandon G Zuccato, Bradley Merker, Laszlo Erdodi
Importance: Estimated base rates of invalid performance on baseline testing (base rates of failure) for the management of sport-related concussion range from 6.1% to 40.0%, depending on the validity indicator used. The instability of this key measure represents a challenge in the clinical interpretation of test results that could undermine the utility of baseline testing. Objectives: To determine the prevalence of invalid performance on baseline testing and to assess whether the prevalence varies as a function of age and validity indicator...
March 12, 2018: JAMA Neurology
Richard M Shiffrin, Katy Börner, Stephen M Stigler
It appears paradoxical that science is producing outstanding new results and theories at a rapid rate at the same time that researchers are identifying serious problems in the practice of science that cause many reports to be irreproducible and invalid. Certainly, the practice of science needs to be improved, and scientists are now pursuing this goal. However, in this perspective, we argue that this seeming paradox is not new, has always been part of the way science works, and likely will remain so. We first introduce the paradox...
March 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Marie Duhamel, Mélanie Rose, Franck Rodet, Adriana-Nathalia Murgoci, Lea Zografidou, Anne Régnier-Vigouroux, Fabien Vanden Abeele, Firas Kobeissy, Serge Nataf, Laurent Pays, Maxence Wisztorski, Dasa Cizkova, Isabelle Fournier, Michel Salzet
High grade gliomas are the most common brain tumors in adult. These tumors are characterized by a high infiltration in microglial cells and macrophages. The immunosuppressive tumor environment is known to orient immune cells towards a pro-tumoral and anti-inflammatory phenotype. Therefore, the current challenge for cancer therapy is to find a way to reorient macrophages toward an anti-tumoral phenotype. Previously, we demonstrated that macrophages secreted anti-tumoral factors when they were invalidated for the proprotein converstase 1/3 (PC1/3) and treated with LPS...
March 12, 2018: Molecular & Cellular Proteomics: MCP
Anita Harrewijn, Melle J W van der Molen, Irene M van Vliet, Renaud L M Tissier, P Michiel Westenberg
Social anxiety disorder is an invalidating psychiatric disorder characterized by extreme fear and avoidance of one or more social situations in which patients might experience scrutiny by others. The goal of this two-generation family study was to delineate behavioral and electrocortical endophenotypes of social anxiety disorder related to social evaluation. Nine families of patients with social anxiety disorder (their spouse and children, and siblings of these patients with spouse and children) performed a social judgment paradigm in which they believed to be evaluated by peers...
2018: NeuroImage: Clinical
Albert Giralt, Pierre-Damien Denechaud, Isabel C Lopez-Mejia, Brigitte Delacuisine, Emilie Blanchet, Caroline Bonner, Francois Pattou, Jean-Sébastien Annicotte, Lluis Fajas
OBJECTIVE: Aberrant hepatic glucose production contributes to the development of hyperglycemia and is a hallmark of type 2 diabetes. In a recent study, we showed that the transcription factor E2F1, a component of the cell cycle machinery, contributes to hepatic steatosis through the transcriptional regulation of key lipogenic enzymes. Here, we investigate if E2F1 contributes to hyperglycemia by regulating hepatic gluconeogenesis. METHODS: We use different genetic models to investigate if E2F1 regulates gluconeogenesis in primary hepatocytes and in vivo...
February 26, 2018: Molecular Metabolism
Franco Marinello, Miquel Kraft, Nuria Ridaura, Francesc Vallribera, Eloy Espín
INTRODUCTION: The treatment of anal fistula with the OTSC® (over-the-scope-clip) proctology device involves the placement of an elastic alloy clip called Nitinol on the internal fistula opening to achieve fistula healing. The aim of this study was to analyze preliminary results of this technique in a case series. METHODS: This was a retrospective analysis of patients who underwent OTSC® clip placement for fistula-in-ano treatment between June 2015 and March 2017 at a specialized colorectal unit...
March 7, 2018: Cirugía Española
Lin Wang, Yingze Zhang, Zhaohui Song, Hengrui Chang, Ye Tian, Fei Zhang
PURPOSE: To describe and evaluate the novel method of using elastic bionic fixation device in treating the distal tibiofibular syndesmosis (DTS) injury. METHODS: From June 2013 to January 2014, 17 subjects with ankle fractures combined with DTS separation were treated by the elastic bionic fixation device. The syndesmotic parameters, healing, functional scores, and possible complications were recorded. RESULTS: All patients had a mean follow-up of 23...
March 9, 2018: International Orthopaedics
Karen Rego, Kristen Pereira, James MacDougall, William Cruikshank
BACKGROUND: Accurate identification of individuals with TB infection, is required to achieve the WHO's End TB Strategy goals. While there is general acceptance that the T-SPOT.TB test borderline category provides an opportunity to increase test resolution of results around the test cut-off point, this has not been investigated. METHODS: 645,947 tests were analyzed to determine frequency of borderline results, effect of age and time between tests and associations between subjects' clinical risk factors and retest results...
January 2018: Tuberculosis
Hai Wang, Libo Man, Guizhong Li, Guanglin Huang, Ning Liu
The Editors are retracting this article [1] because post-publication peer review has identified multiple errors in the methodology of this meta-analysis, which invalidate the conclusions drawn.
March 9, 2018: Nutrition Journal
Jia Zhang, Jiming Yin, Yangjia Wang, Bin Li, Xiangjun Zeng
The cause of the invalid reaction of smooth muscle cells to mechanical stimulation that results in a dysfunctional myogenic response that mediates the disruption of renal blood flow (RBF) in diabetic patients is debatable. The present study revealed that increased apelin concentration in serum of diabetic mice neutralized the myogenic response mediated by apelin receptor (APJ) and resulted in increased RBF, which promoted the progression of diabetic nephropathy. The results showed that apelin concentration, RBF, and albuminuria:creatinine ratio were all increased in kkAy mice, and increased RBF correlated positively to serum apelin both in C57 and diabetic mice...
March 9, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Jane H Brice, Matthew A Psioda, Renee Johnson, Amy Oakley, Julianne M Cyr, Christopher S Cowden, Richard Uribe
BACKGROUND: Accessing the emergency medical services system via 9-1-1 operators is an effective way for patients to seek urgent health care; however, technological advances and telecommunication practices inundate the 9-1-1 and emergency services infrastructure with unintentional calls that delay response efforts to legitimate medical emergencies. OBJECTIVE: To determine whether the change in university-wide dial-out prefix from "9" to "7" reduced unnecessary calls to a 9-1-1 call center...
March 9, 2018: Prehospital Emergency Care
Timothy L Hubbard, Susan E Ruppel
In illusory line motion, presentation of a cue is followed by presentation of a nearby stationary line, and the line is perceived to "unfold," "expand," or "extend" away from the cue. Effects of the allocation of attention regarding where the cue or the line would be presented were measured in three experiments, and ratings of relative velocity and relative strength of illusory motion were collected. Findings included (a) relative velocity and relative strength decreased with increases in SOA from 50 to 450 ms, (b) relative velocity and relative strength were not influenced by whether illusory motion moved from one end of the line to the other or from both ends toward the middle of the line, (c) increased uncertainty regarding where the line would appear did not influence relative velocity or relative strength, and (d) valid pre-cues regarding the location of a cue resulted in faster relative velocity than did invalid pre-cues, but pre-cue validity did not influence relative strength...
2018: Frontiers in Psychology
Huifang Zhao, Jing Li, Xuejin Zhang
In this work, a fundamental understanding of oxygen delignification distracted by dissolved lignin was investigated. In the new biorefinery model of shortening kraft pulping integrated with extended oxygen delignification process, increasing content of residual lignin in the original pulp could result in enhanced delignification efficiency, higher pulp viscosity and less carbonyl groups. However, the invalid oxygen consumption by dissolved lignin could be increased with the increase of process temperature and alkali dosage...
February 27, 2018: Bioresource Technology
Tao Wang, Qin-Rui Xing, Hui Wang, Wei Chen
The number of articles published in open access journals (OAJs) has increased dramatically in recent years. Simultaneously, the quality of publications in these journals has been called into question. Few studies have explored the retraction rate from OAJs. The purpose of the current study was to determine the reasons for retractions of articles from OAJs in biomedical research. The Medline database was searched through PubMed to identify retracted publications in OAJs. The journals were identified by the Directory of Open Access Journals...
March 7, 2018: Science and Engineering Ethics
Taly Bonder, Daniel Gopher, Yaffa Yeshurun
The present study examined the mutual influence of cortical neuroenhancement and allocation of spatial attention on perception. Specifically, it explored the effects of transcranial Direct Current Stimulation (tDCS) on visual acuity measured with a Landolt gap task and attentional precues. The exogenous cues were used to draw attention either to the location of the target or away from it, generating significant performance benefits and costs. Anodal tDCS applied to posterior occipital area for 15 min improved performance during stimulation, reflecting heightened visual acuity...
2018: Frontiers in Psychology
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