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https://www.readbyqxmd.com/read/27910397/enhanced-magnetic-field-probe-array-for-improved-excluded-flux-calculations-on-the-c-2u-advanced-beam-driven-field-reversed-configuration-plasma-experiment
#1
T Roche, M C Thompson, R Mendoza, I Allfrey, E Garate, J Romero, J Douglass
External flux conserving coils were installed onto the exterior of the C-2U [M. W. Binderbauer et al., Phys. Plasmas 22, 056110 (2015)] confinement vessel to increase the flux confinement time of the system. The 0.5 in. stainless steel vessel wall has a skin time of ∼5 ms. The addition of the external copper coils effectively increases this time to ∼7 ms. This led to better-confined/longer-lived field-reversed configuration (FRC) plasmas. The fringing fields generated by the external coils have the side effect of rendering external field measurements invalid...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27906186/preimplantation-factor-is-an-anti-apoptotic-effector-in-human-trophoblasts-involving-p53-signaling-pathway
#2
Hadia Moindjie, Esther Dos Santos, Rita-Josiane Gouesse, Nelly Swierkowski-Blanchard, Valérie Serazin, Eytan R Barnea, François Vialard, Marie-Noëlle Dieudonné
From the earliest stages of gestation, embryonic-maternal interaction has a key role in a successful pregnancy. Various factors present during gestation may significantly influence this type of juxta/paracrine interaction. PreImplantation Factor (PIF) is a recently identified factor with activity at the fetomaternal interface. PIF is secreted by viable embryos and directly controls placental development by increasing the invasive capacity of human extravillous trophoblasts (EVTs). To further specify PIF's role in the human placenta, we analyzed the genome-wide expression profile of the EVT in the presence of a synthetic PIF analog (sPIF)...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27903438/neurite-density-imaging-versus-imaging-of-microscopic-anisotropy-in-diffusion-mri-a-model-comparison-using-spherical-tensor-encoding
#3
Björn Lampinen, Filip Szczepankiewicz, Johan Mårtensson, Danielle van Westen, Pia C Sundgren, Markus Nilsson
In diffusion MRI (dMRI), microscopic diffusion anisotropy can be obscured by orientation dispersion. Separation of these properties is of high importance, since it could allow dMRI to non-invasively probe elongated structures such as neurites (axons and dendrites). However, conventional dMRI, based on single diffusion encoding (SDE), entangles microscopic anisotropy and orientation dispersion with intra-voxel variance in isotropic diffusivity. SDE-based methods for estimating microscopic anisotropy, such as the neurite orientation dispersion and density imaging (NODDI) method, must thus rely on model assumptions to disentangle these features...
November 26, 2016: NeuroImage
https://www.readbyqxmd.com/read/27902313/streptomyces-caelicus-an-antibiotic-producing-species-of-the-genus-streptomyces-and-streptomyces-canchipurensis-li-et-al-2014-are-later-heterotypic-synonym-of-streptomyces-muensis-ningthoujam-et-al-2013
#4
Joachim Wink, Peter Schumann, Hans-Peter Klenk, Nestor Zaburannyi, Martin Westermann, Karin Martin, Stefanie P Glaeser, Peter Kämpfer, Ewelina Atasayar
"Streptomyces caelicus" DSM 40835T was first reported as the producer of the antibiotic griselimycin by some coworkers of Rhone Poulenc in 1971. The project on isolation of the antibiotic compound was stopped because of the bad solubility and selectivity of the compound towards Mycobacteria. At Sanofi-Aventis, Germany, the project was re-evaluated in 2007 and the gene cluster of griselimycin could be identified, characterized and was patented in 2013. At this time, "S. caelicus" was an invalid name. During the strain characterization work it was found, that S...
October 26, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27896874/five-myths-about-variable-selection
#5
REVIEW
Georg Heinze, Daniela Dunkler
Multivariable regression models are often used in transplantation research to identify or to confirm baseline variables which have an independent association, causally or only evidenced by statistical correlation, with transplantation outcome. Although sound theory is lacking, variable selection is a popular statistical method which seemingly reduces the complexity of such models. However, in fact, variable selection often complicates analysis as it invalidates common tools of statistical inference such as p-values and confidence intervals...
November 29, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27896714/stopping-ability-in-younger-and-older-adults-behavioral-and-event-related-potential
#6
Shulan Hsieh, Yu-Chi Lin
This study examines age-related differences in inhibitory control as measured by stop-signal performance. The participants were 24 adults aged 20-30 years and 24 older adults aged 61-76 years. The task blocks were pure choice reaction-time blocks, global stop-signal blocks (with an auditory stop signal), and selective stop-signal blocks (with valid and invalid stop signals). There was a decline in reactive inhibitory control for the older group reflected by greater stop-signal reaction times and reduced P3 peak amplitudes in both global and selective stop-signal task blocks...
November 28, 2016: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/27893213/reliability-and-validity-of-data-obtained-from-alcohol-cannabis-and-gambling-populations-on-amazon-s-mechanical-turk
#7
Hyoun S Kim, David C Hodgins
Researchers recently have begun using Mechanical Turk (MTurk), an online crowdsourcing platform, to recruit addiction populations. However, whether the data obtained from substance users and gamblers on MTurk are reliable and valid is unknown. Herein, we assessed the internal and retest reliability of and concurrent and convergent validity of data obtained from addiction populations on MTurk. Current drinkers (N = 208), cannabis users (N = 200), and gamblers (N = 200) residing in the United States completed measures of alcohol, cannabis, and gambling severity, psychological constructs (e...
November 28, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27892806/wisconsin-card-sorting-test-embedded-validity-indicators-developed-for-adults-can-be-extended-to-children
#8
Jonathan D Lichtenstein, Laszlo A Erdodi, Jaspreet K Rai, Anya Mazur-Mosiewicz, Lloyd Flaro
Past studies have examined the ability of the Wisconsin Card Sorting Test (WCST) to discriminate valid from invalid performance in adults using both individual embedded validity indicators (EVIs) and multivariate approaches. This study is designed to investigate whether the two most stable of these indicators-failures to maintain set (FMS) and the logistical regression equation S-BLRE-can be extended to pediatric populations. The classification accuracy for FMS and S-BLRE was examined in a mixed clinical sample of 226 children aged 7 to 17 years (64...
November 28, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/27891762/judicial-reliance-on-parental-iq-in-appellate-level-child-welfare-cases-involving-parents-with-intellectual-and-developmental-disabilities
#9
Ella Callow, Munazza Tahir, Maurice Feldman
BACKGROUND: Parents with intellectual and developmental disabilities (IDDs) are over-represented in child welfare cases. Although IQ per se is an invalid indicator of parenting abilities, this study examined the prevalence of judicial consideration of parental IQ test evidence in US appellate cases. METHODS: The present authors conducted Boolean searches of Westlaw Corporation's case database since 1999. The present authors used a six-question checklist to survey the 42 most recent American appellate cases involving termination of parental rights (TPR) decisions that included evidence of parental intellectual and developmental disabilities based on IQ...
November 27, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/27891617/signet-ring-cell-carcinoma-of-resectable-metastatic-colorectal-cancer-has-rare-surgical-value
#10
Jianfei Fu, Lunpo Wu, Mengjie Jiang, Yinuo Tan, Dan Li, Fei Chen, Ting Jiang, Jinlin Du
BACKGROUND AND OBJECTIVES: Signet ring cell carcinoma (SRCC) is a uniquely separated subgroup in metastatic colorectal cancer (mCRC). The aims are to investigate the value of resection in patients with resectable metastatic signet ring cell colorectal cancer. METHODS: Patients with mCRC who underwent resection in Surveillance, Epidemiology, and End Results database during 1998-2010 were retrospectively analyzed. Kaplan-Meier and COX models were used to analyze the differences in the survival...
November 27, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27890735/variabilty-of-obstructive-sleep-apnea-analysis-of-pacemaker-detected-respiratory-disturbances
#11
Ghassan Moubarak, Abdeslam Bouzeman, Thibaut De Geyer D'orth, Claire Bouleti, Christine Beuzelin, Serge Cazeau
BACKGROUND: Obstructive sleep apnea (OSA) is associated with several cardiovascular conditions. Some pacemakers feature specific algorithms detecting respiratory cycles and deriving indexes well correlated with identification of polysomnography-confirmed severe OSA. OBJECTIVE: To analyze respiratory disturbances measured by a validated algorithm in clinical practice, describe their variations over time and their association with atrial fibrillation. METHODS: Fifty-eight patients implanted with dual-chamber LivaNova Reply 200DR or Kora 100DR pacemakers measuring a Respiratory Disturbance Index (RDI) were included...
November 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27888354/effects-of-reward-and-punishment-on-the-interaction-between-going-and-stopping-in-a-selective-stop-change-task
#12
Frederick Verbruggen, Rosamund McLaren
Inhibition of no-longer relevant go responses supports flexible and goal-directed behavior. The present study explored if the interaction between going and stopping is influenced by monetary incentives. Subjects (N = 108) performed a selective stop-change task, which required them to stop and change a go response if a valid signal occurred, but to execute the planned go response if invalid signals or no signals occurred. There were two incentive groups: the punishment group lost points for unsuccessful valid-signal trials, whereas the reward group gained points for successful valid-signal trials...
November 25, 2016: Psychological Research
https://www.readbyqxmd.com/read/27887912/application-of-the-strobe-statement-to-the-hypospadias-literature-report-of-the-international-pediatric-urology-task-force-on-hypospadias
#13
Luis H Braga, Armando J Lorenzo, Darius J Bagli, Joao L Pippi Salle, Anthony Caldamone
INTRODUCTION: Observational studies, particularly case series, represent the majority of the current hypospadias research. As a result, this literature lacks standardization of surgical techniques, uniform definitions of hypospadias complications, and consistency of outcome reporting, which may make it difficult to compare results across studies. A modified version of the STROBE statement, containing 20 items, was presented at the International Pediatric Urology Task Force on Hypospadias meeting to assist with clear and transparent reporting of hypospadias studies...
August 22, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27886027/epidemiology-of-hepatitis-c-in-the-republic-of-moldova-achievements-and-remaining-challenges-in-prevention-and-control
#14
Vladimir Guriev, Constantin Spinu, Octavian Sajen, Maria Isac, Igor Spinu, Svetlana Cebotari, Ala Donos
Viral hepatitis, especially those with parenteral and sexual transmission, still remain a major problem of public health, both globally and for the Republic of Moldova, due to wide spreading, endemicity, increased morbidity and mortality and high rate of invalidity following the chronization of infection, but usually neglected by population and public health authorities. This paper describes the epidemiology and preventive and control measures of hepatitis C in Moldova. Epidemiological analysis of the surveillance data on hepatitis C incidence in the Republic of Moldova was conducted...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27884952/how-violence-constitutes-order-consent-coercion-and-censure-in-tanzania
#15
Hilde Jakobsen
Survey data show that most Tanzanian women find wife-beating justifiable. What is the meaning of the violence that enjoys such broad social approval? Does respect for women's agency invalidate feminist opposition to wife-beating? I explore these questions by analyzing data on hegemonic norms generated through 27 focus group discussions in Arumeru and Kigoma-Vijijini districts, and find that wife-beating was supported for its role in constituting social order. This analysis of how exactly violence can constitute order yielded insights into the interplay between violence and consent that are theoretically relevant to violence against women in other forms and contexts, reminding researchers and practitioners of the role of power and coercion in supposedly agreed-upon community norms...
November 23, 2016: Violence Against Women
https://www.readbyqxmd.com/read/27882504/media-portrayal-of-a-landmark-neuroscience-experiment-on-free-will
#16
Eric Racine, Valentin Nguyen, Victoria Saigle, Veljko Dubljevic
The concept of free will has been heavily debated in philosophy and the social sciences. Its alleged importance lies in its association with phenomena fundamental to our understandings of self, such as autonomy, freedom, self-control, agency, and moral responsibility. Consequently, when neuroscience research is interpreted as challenging or even invalidating this concept, a number of heated social and ethical debates surface. We undertook a content analysis of media coverage of Libet's et al.'s (Brain 106(Pt 3):623-642, 1983) landmark study, which is frequently interpreted as posing a serious challenge to the existence of free will...
November 23, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27881620/catching-fakes-new-markers-of-urine-sample-validity-and-invalidity
#17
Melissa M Goggin, Cheng-Min Tann, Anna Miller, An Nguyen, Gregory C Janis
Urine drug testing is common for workplace drug testing, prescription management, emergency medicine and the criminal justice system. Unsurprisingly, with the significant consequences based upon the results of urine drug testing, a donor in need of concealing the contents of their sample is highly motivated to cheat the process. Procedures and safeguards ensuring sample validity are well known, and include measuring sample temperature at the time of collection, and laboratory measurements of creatinine, specific gravity and pH...
November 22, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27863137/a-philosophical-framework-for-integrating-systems-pharmacology-models-into-pharmacometrics
#18
REVIEW
S B Duffull
The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits into the overall scientific approach.
November 12, 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27862284/dystonia-deafness-syndrome-caused-by-a-%C3%AE-actin-gene-mutation-and-response-to-deep-brain-stimulation
#19
Hendriekje Eggink, Martje E van Egmond, Corien C Verschuuren-Bemelmans, Marleen C Schönherr, Tom J de Koning, D L Marinus Oterdoom, J Marc C van Dijk, Marina A J Tijssen
INTRODUCTION: Dystonia-deafness syndrome is a distinct clinical presentation within the dystonia-spectrum. Although several genetic and acquired causes have been reported, etiology remains unknown in the majority of patients. OBJECTIVES: To describe two patients with dystonia-deafness syndrome due to a beta-actin gene mutation. METHODS: We report on disease course, genetic testing, and management of 2 patients, mother and daughter, presenting with dystonia-deafness syndrome...
November 8, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27861538/development-and-validation-of-a-new-mouse-model-to-investigate-the-role-of-sv2a-in-epilepsy
#20
Catherine Menten-Dedoyart, Maria Elisa Serrano Navacerrada, Odile Bartholome, Judit Sánchez Gil, Virginie Neirinckx, Sabine Wislet, Guillaume Becker, Alain Plenevaux, Priscilla Van den Ackerveken, Bernard Rogister
SV2A is a glycoprotein present in the membranes of most synaptic vesicles. Although it has been highly conserved throughout evolution, its physiological role remains largely unknown. Nevertheless, Levetiracetam, a very effective anti-epileptic drug, has been recently demonstrated to bind to SV2A. At present, our understanding of the normal function of SV2A and its possible involvement in diseases like epilepsy is limited. With this study, we sought to develop a relevant model enabling analysis of SV2A's role in the occurrence or progression of epilepsy...
2016: PloS One
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