keyword
MENU ▼
Read by QxMD icon Read
search

invalidity

keyword
https://www.readbyqxmd.com/read/28550707/micrornas-correlate-with-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder-in-a-chinese-population
#1
Jianglong Chen, Jiting Zhu, Zeng Wang, Xiaoping Yao, Xuan Wu, Fang Liu, Weidong Zheng, Zhiwen Li, Aiyu Lin
BACKGROUND Recent studies identified a set of differentially expressed miRNAs in whole blood that may discriminate neuromyelitis optica spectrum disorders (NMOSD) from relapsing-remitting multiple sclerosis (RRMS). This study invalidated 9 known miRNAs in Chinese patients. MATERIAL AND METHODS The levels of miRNAs in whole blood were assayed in healthy controls (n=20) and patients with NMOSD (n=45), RRMS (n=17) by quantitative real-time polymerase chain reaction (qRT-PCR), and pairwise-compared between groups...
May 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28548578/emotional-cognitive-and-behavioral-reactions-to-paranoid-symptoms-in-clinical-and-nonclinical-populations
#2
Célia Barreto Carvalho, Carolina da Motta, José Pinto-Gouveia, Ermelindo Manuel Bernardo Peixoto
BACKGROUND: Paranoia is a disruptive belief that can vary across a continuum, ranging from persecutory delusions presented in clinical settings to paranoid cognitions that are highly prevalent in the general population. The literature suggests that paranoid thoughts derive from the activation of a paranoid schema or information processing biases that can be sensitive to socially ambiguous stimuli and influence the processing of threatening situations. METHODS: Four groups (schizophrenic participants in active psychotic phases, n=61; stable participants in remission, n=30; participants' relatives, n=32; and, healthy controls, n=64) were assessed with self-report questionnaires to determine how the reactions to paranoia of clinical patients differ from healthy individuals...
2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28548129/central-pathology-review-with-two-stage-quality-assurance-for-pathological-response-after-neoadjuvant-chemotherapy-in-the-artemis-trial
#3
Jeremy St John Thomas, Elena Provenzano, Louise Hiller, Janet Dunn, Clare Blenkinsop, Louise Grybowicz, Anne-Laure Vallier, Ioannis Gounaris, Jean Abraham, Luke Hughes-Davies, Karen McAdam, Stephen Chan, Rizvana Ahmad, Tamas Hickish, Stephen Houston, Daniel Rea, Carlos Caldas, John Ms Bartlett, David Allan Cameron, Richard Laurence Hayward, Helena Margaret Earl
The ARTemis Trial tested standard neoadjuvant chemotherapy±bevacizumab in the treatment of HER2-negative early breast cancer. We compare data from central pathology review with report review and also the reporting behavior of the two central pathologists. Eight hundred women with HER2-negative early invasive breast cancer were recruited. Response to chemotherapy was assessed from local pathology reports for pathological complete response in breast and axillary lymph nodes. Sections from the original core biopsy and surgical excision were centrally reviewed by one of two trial pathologists blinded to the local pathology reports...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28548078/associated-variables-of-myositis-in-systemic-lupus-erythematosus-a-cross-sectional-study
#4
Yan Liang, Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye
BACKGROUND This study aimed to estimate the point prevalence of myositis and identify associated variables of myositis in systemic lupus erythematosus (SLE). MATERIAL AND METHODS Clinical date of patients hospitalized with lupus at the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital were collected. Patients were defined as having myositis if they reported the presence of persistent invalidating muscular weakness combined with increased levels of creatine phosphokinase (CPK) and abnormal electromyography (EMG)...
May 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28547210/greater-accuracy-and-broadened-applicability-of-phase-reduction-using-isostable-coordinates
#5
Dan Wilson, Bard Ermentrout
The applicability of phase models is generally limited by the constraint that the dynamics of a perturbed oscillator must stay near its underlying periodic orbit. Consequently, external perturbations must be sufficiently weak so that these assumptions remain valid. Using the notion of isostables of periodic orbits to provide a simplified coordinate system from which to understand the dynamics transverse to a periodic orbit, we devise a strategy to correct for changing phase dynamics for locations away from the limit cycle...
May 25, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28543762/male-partnered-bisexual-women-s-perceptions-of-disclosing-sexual-orientation-to-family-across-the-transition-to-parenthood-intensifying-heteronormativity-or-queering-family
#6
Abbie E Goldberg, Katherine R Allen, Themal Ellawala, Lori E Ross
Drawing from queer and communication privacy management frameworks, this study examines the narratives of 22 bisexual, male-partnered women who were interviewed during the perinatal period and one year postnatally about their disclosures of sexual identity to family of origin. Most women rarely discussed their sexual identity with family; participants who had disclosed described such disclosures as provoking discomfort. Some women stated that their parental status seemed to invalidate the need to talk about their sexual history or identity with family, due its declining salience and increased concerns about judgment...
May 24, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28541210/walking-gait-step-length-asymmetry-induced-by-handheld-device
#7
Mahdi Abid, Valerie Renaudin, Yannick Aoustin, Eric Le Carpentier, Thomas Robert
The modeling and feature extraction of human gait motion are crucial in biomechanics studies, human localization and robotics applications. Recent studies in pedestrian navigation aim at extracting gait features based on the data of low-cost sensors embedded in handheld devices such as smartphones. The general assumption in Pedestrian Dead Reckoning (PDR) strategy for navigation application is that the presence of a device in hand does not impact the gait symmetry and that all steps are identical. This hypothesis, which is used to estimate the traveled distance, is investigated in this paper with an experimental study...
May 18, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28539893/more-than-attentional-tuning-investigating-the-mechanisms-underlying-practice-gains-and-preparation-in-task-switching
#8
Mike Wendt, Stina Klein, Tilo Strobach
In task switching, participants perform trials of task repetitions (i.e., the same task is executed in consecutive trials) and task switches (i.e., different tasks are executed in consecutive trials) and the longer reaction times in switch trials in comparison to these times in repetition trials are referred to as switch costs. These costs are reduced by lengthening of an interval following a cue that indicates the upcoming task; this effect demonstrated effective task preparation. To investigate the role of task switching practice for these preparation effects and task switch costs, we applied a task switching paradigm, involving two digit classification tasks, in six successive practice sessions and varied the length of the preparation interval...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28536532/phase-partitioning-of-gm1-and-its-bodipy-labeled-analog-determine-their-different-binding-to-cholera-toxin
#9
Sami Rissanen, Michal Grzybek, Adam Orłowski, Tomasz Róg, Oana Cramariuc, Ilya Levental, Christian Eggeling, Erdinc Sezgin, Ilpo Vattulainen
Driven by interactions between lipids and proteins, biological membranes display lateral heterogeneity that manifests itself in a mosaic of liquid-ordered (Lo) or raft, and liquid-disordered (Ld) or non-raft domains with a wide range of different properties and compositions. In giant plasma membrane vesicles and giant unilamellar vesicles, specific binding of Cholera Toxin (CTxB) to GM1 glycolipids is a commonly used strategy to label raft domains or Lo membrane environments. However, these studies often use acyl-chain labeled bodipy-GM1 (bdGM1), whose headgroup accessibility and membrane order or phase partitioning may differ from those of GM1, rendering the interpretation of CTxB binding data quite problematic...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28535619/prevalence-and-incidence-of-osteoporotic-fractures-in-patients-on-long-term-glucocorticoid-treatment-for-rheumatic-diseases-the-glucocorticoid-induced-osteoporosis-tool-giotto-study
#10
M Rossini, O Viapiana, M Vitiello, N Malavolta, G La Montagna, S Maddali Bongi, O Di Munno, R Nuti, C U Manzini, C Ferri, L Bogliolo, A Mathieu, F Cantatore, A Del Puente, M Muratore, W Grassi, B Frediani, G Saviola, P Delvino, L Mirone, G Ferraccioli, G Tripi, I Piazza, D Gatti
Osteoporosis and fractures are common and invalidating consequences of chronic glucorticoid (GC) treatment. Reliable information regarding the epidemiology of GC induced osteoporosis (GIOP) comes exclusively from the placebo group of randomized clinical trials while observational studies are generally lacking data on the real prevalence of vertebral fractures, GC dosage and primary diagnosis. The objective of this study was to evaluate the prevalence and incidence of osteoporotic fractures and to identify their major determinants (primary disease, GC dosage, bone mineral density, risk factors, specific treatment for GIOP) in a large cohort of consecutive patients aged >21 years, on chronic treatment with GC (≥5 mg prednisone - PN - equivalent) and attending rheumatology centers located all over Italy...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28533632/local-ph-monitoring-of-small-cluster-of-cells-using-a-fiber-optic-dual-core-micro-probe
#11
Sisi Chen, Qingbo Yang, Hai Xiao, Honglan Shi, Yinfa Ma
Biological studies of tissues and cells have enabled numerous discoveries, but these studies still bear potential risks of invalidation because of cell heterogeneity. Through high-accuracy techniques, recent studies have demonstrated that discrepancies do exist between the results from low-number-cell studies and cell-population-based results. Thus the urgent need to re-evaluate key principles on limited number of cells has been provoked. In this study, a novel designed dual-core fiber-optic pH micro-probe was fabricated and demonstrated for niche environment pH sensing with high spatial resolution...
March 31, 2017: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/28532207/tutorial-on-biostatistics-statistical-analysis-for-correlated-binary-eye-data
#12
Gui-Shuang Ying, Maureen G Maguire, Robert Glynn, Bernard Rosner
PURPOSE: To describe and demonstrate methods for analyzing correlated binary eye data. METHODS: We describe non-model based (McNemar's test, Cochran-Mantel-Haenszel test) and model-based methods (generalized linear mixed effects model, marginal model) for analyses involving both eyes. These methods were applied to: (1) CAPT (Complications of Age-related Macular Degeneration Prevention Trial) where one eye was treated and the other observed (paired design); (2) ETROP (Early Treatment for Retinopathy of Prematurity) where bilaterally affected infants had one eye treated conventionally and the other treated early and unilaterally affected infants had treatment assigned randomly; and (3) AREDS (Age-Related Eye Disease Study) where treatment was systemic and outcome was eye-specific (both eyes in the same treatment group)...
May 22, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28531333/the-flaws-in-the-detail-of-an-observational-study-on-transcatheter-aortic-valve-implantation-versus-surgical-aortic-valve-replacement-in-intermediate-risks-patients
#13
Fabio Barili, Nick Freemantle, Thierry Folliguet, Claudio Muneretto, Michele De Bonis, Martin Czerny, Jean Francois Obadia, Nawwar Al-Attar, Nikolaos Bonaros, Jolanda Kluin, Roberto Lorusso, Prakash Punjabi, Rafael Sadaba, Piotr Suwalski, Umberto Benedetto, Andreas Böning, Volkmar Falk, Miguel Sousa-Uva, Pieter A Kappetein, Lorenzo Menicanti
The PARTNER group recently published a comparison between the latest generation SAPIEN 3 transcatheter aortic valve implantation (TAVI) system (Edwards Lifesciences, Irvine, CA, USA) and surgical aortic valve replacement (SAVR) in intermediate-risk patients, apparently demonstrating superiority of the TAVI and suggesting that TAVI might be the preferred treatment method in this risk class of patients. Nonetheless, assessment of the non-randomized methodology used in this comparison reveals challenges that should be addressed in order to elucidate the validity of the results...
June 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28529409/an-experimental-check-of-backscattering-interferometry
#14
Michael M Baksh, M G Finn
Backscattering interferometry (BSI) was used to determine the association constants for four well-known biomolecular interactions: protein A + IgG, trypsin + antitrypsin, trypsin + p-aminobenzamidine, and antithrombin + heparin. Each gave well-defined binding curves and Kd values in close agreement with published findings obtained using other techniques. These results stand in direct contrast to the claims in a 2015 publication in this journal (Discussion of "Back Scattering Interferometry revisited-a theoretical and experimental investigation" Jørgensen, T...
May 2017: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/28528655/pulmonary-flow-as-an-improved-method-for-determining-cardiac-output-in-mice-after-myocardial-infarction
#15
Mathew J Platt, Jason S Huber, Keith R Brunt, Jeremy A Simpson
BACKGROUND: Echocardiography is a valuable noninvasive technique to estimate cardiac output (CO) from the left ventricle (LV) not only in clinical practice but also in small-animal experiments. CO is used to grade cardiac function and is especially important when investigating cardiac injury (e.g., myocardial infarction [MI]). Critically, MI deforms the LV, invalidating the assumptions fundamental to calculating of cardiac volumes directly from the LV. Thus, the purpose of this study was to determine if Doppler-derived blood flow through the pulmonary trunk (pulmonary flow [PF]) was an improved method over conventional LV-dependent echocardiography to accurately determine CO after MI...
June 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28524432/solution-nmr-structure-of-a-ligand-hybrid-2-g-quadruplex-complex-reveals-rearrangements-that-affect-ligand-binding
#16
Julia Wirmer-Bartoschek, Lars Erik Bendel, Hendrik R A Jonker, J Tassilo Grün, Francesco Papi, Carla Bazzicalupi, Luigi Messori, Paola Gratteri, Harald Schwalbe
Telomeric G-quadruplexes have recently emerged as drug targets in cancer research. Herein, we present the first NMR structure of a telomeric DNA G-quadruplex that adopts the biologically relevant hybrid-2 conformation in a ligand-bound state. We solved the complex with a metalorganic gold(III) ligand that stabilizes G-quadruplexes. Analysis of the free and bound structures reveals structural changes in the capping region of the G-quadruplex. The ligand is sandwiched between one terminal G-tetrad and a flanking nucleotide...
May 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28522742/evaluation-of-radiopharmaceutical-adverse-reaction-reports-to-the-british-nuclear-medicine-society-for-the-period-2007-to-2016
#17
Tracia-Gay Kennedy-Dixon, Maxine Gossell-Williams, Margaret Cooper, Moez Trabelsi, Sobhan Vinjamuri
Objective: This study sought to answer the calls for the restoration of reports of adverse reactions from the European Association of Nuclear Medicine. It assessed reports of adverse reactions to radiopharmaceuticals (ARRPs) that were submitted to the British Nuclear Medicine Society's (BNMS) Radiopharmaceutical Adverse Reactions and Product Defects online database during the period January 2007 to December 2016. Methodology: This investigation was a pharmacovigilance based, non-experimental, cross-sectional study aimed at finding the prevalence and association between radiopharmaceuticals and adverse reactions...
May 18, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28520974/the-neuropsychological-assessment-of-justice-involved-men-descriptive-analysis-preliminary-data-and-a-case-for-group-specific-norms
#18
Casey LaDuke, David DeMatteo, Kirk Heilbrun, Jennifer Gallo, Thomas Swirsky-Sacchetti
Objective: Neuropsychological expertise has played an increasing role in legal decision-making in criminal contexts. Valid neuropsychological evidence in criminal forensic contexts requires normative data that are representative of justice-involved individuals. Unfortunately, existing normative data appear unlikely to represent justice-involved individuals due to significant demographic and clinical factors specific to this population. As a result, the interpretation of neuropsychological performance with justice-involved individuals using existing normative data may increase the risk of inaccurate description, invalid clinical conceptualization, misdiagnosis of impairment, and misattribution of deficits in functional-legal capacities...
May 18, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28513347/development-and-initial-validation-of-an-inconsistent-responding-scale-for-the-youth-psychopathic-traits-inventory
#19
Brittany N Penson, Jared R Ruchensky, John F Edens, Brent Donnellan, Michael G Vaughn, Hedwig Eisenbarth
The Youth Psychopathic Traits Inventory (YPI) is widely used in research, but there currently exist no means to identify potentially invalid protocols resulting from careless or random responding. We describe the development of an inconsistent responding scale for the YPI using three archival samples of youths, including two from the United States (juvenile justice and middle school) and one from Germany (vocational training school). We first identified pairs of correlated YPI items and then created a total score based on the sum of the absolute value of the differences for each item pair...
May 17, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28510505/papillary-thyroid-cancer-the-good-and-bad-of-the-good-cancer
#20
Reese W Randle, Norah M Bushman, Jason Orne, Courtney J Balentine, Elizabeth Wendt, Megan C Saucke, Susan C Pitt, Cameron L Macdonald, Nadine P Connor, Rebecca S Sippel
BACKGROUND: Papillary thyroid cancer is often described as the "good cancer" because of its treatability and relatively favorable survival rates. We sought to characterize the thoughts of papillary thyroid cancer patients as they relate to having the "good cancer." METHODS: This qualitative study included 31 papillary thyroid cancer patients enrolled in an ongoing randomized trial. We conducted semi-structured interviews with participants at the pre-operative visit and 2 weeks, 6 weeks, 6 months and 1 year after thyroidectomy...
May 16, 2017: Thyroid: Official Journal of the American Thyroid Association
keyword
keyword
87025
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"