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https://www.readbyqxmd.com/read/28737294/a-call-to-action-towards-an-evidence-based-approach-to-using-verbal-encouragement-during-maximal-exercise-testing
#1
REVIEW
Adrian W Midgley, David C Marchant, Andrew R Levy
By definition, maximal exercise testing inherently requires participants to give a maximal effort. This is an important practical issue as submaximal efforts can produce invalid test results. Verbal encouragement is commonly used to motivate participants to maintain or increase effort investment during maximal exercise testing. Accordingly, studies have reported significant increases in time to exhaustion of between 8% and 18% during VO2max and multistage shuttle run tests, and a significant 30·5 m mean increase in 6-min walk test distance...
July 24, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28731886/collegiate-student-athletes-with-history-of-adhd-or-academic-difficulties-are-more-likely-to-produce-an-invalid-protocol-on-baseline-impact-testing
#2
Lisa Manderino, John Gunstad
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) and other academically-relevant diagnoses have been suggested as modifiers of neurocognitive testing in sport-related concussion, such as Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). These preexisting conditions may suppress ImPACT scores to the extent that they are indistinguishable from low scores because of poor effort. The present study hypothesized that student athletes with history of ADHD or academic difficulties produce lower ImPACT composite scores and are more likely to produce invalid protocols than those without such conditions...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28725706/the-effect-of-deep-brain-stimulation-on-the-non-motor-symptoms-of-parkinson-s-disease-a-critical-review-of-the-current-evidence
#3
REVIEW
Mónica M Kurtis, Thadshani Rajah, Luisa F Delgado, Haidar S Dafsari
The benefit of deep brain stimulation (DBS) in controlling the motor symptoms of Parkinson's disease is well established, however, the impact on the non-motor symptoms (NMS) remains to be elucidated, although the growing investigative efforts are promising. This article reviews the reported data and considers the level of evidence available with regard to the effect of DBS on NMS total burden and on the cognitive, neuropsychiatric, sleep, pain, dysautonomic, and weight domains. Multiple case series suggest that DBS improves the burden of NMS by reducing prevalence, intensity, and non-motor fluctuations...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28720618/interpretation-of-cis-in-clinical-trials-with-non-significant-results-systematic-review-and-recommendations
#4
Jennifer S Gewandter, Michael P McDermott, Rachel A Kitt, Jenna Chaudari, James G Koch, Scott R Evans, Robert A Gross, John D Markman, Dennis C Turk, Robert H Dworkin
OBJECTIVES: Interpretation of CIs in randomised clinical trials (RCTs) with treatment effects that are not statistically significant can distinguish between results that are 'negative' (the data are not consistent with a clinically meaningful treatment effect) or 'inconclusive' (the data remain consistent with the possibility of a clinically meaningful treatment effect). This interpretation is important to ensure that potentially beneficial treatments are not prematurely abandoned in future research or clinical practice based on invalid conclusions...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28717828/statistical-challenges-in-modelling-the-health-consequences-of-social-mobility-the-need-for-diagonal-reference-models
#5
Jeroen van der Waal, Stijn Daenekindt, Willem de Koster
OBJECTIVES: Various studies on the health consequences of socio-economic position address social mobility. They aim to uncover whether health outcomes are affected by: (1) social mobility, besides, (2) social origin, and (3) social destination. Conventional methods do not, however, estimate these three effects separately, which may produce invalid conclusions. We highlight that diagonal reference models (DRMs) overcome this problem, which we illustrate by focusing on overweight/obesity (OWOB)...
July 17, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28717823/-interdisciplinary-pain-assessment-in-the-hospital-setting-merely-a%C3%A2-door-opener-to-multimodal-pain-therapy
#6
E Sens, M Mothes-Lasch, J F Lutz
BACKGROUND: Chronic pain is characterized by a complex interaction of somatic, mental and social factors. Assessing these factors in patients with chronic pain is vital during the diagnostic work-up and when making a structured treatment plan. Interdisciplinary pain assessment (ISA) is the most promising method to deal with these challenges. This article presents our experience in performing pain assessments in the hospital setting and also illustrates the characteristic features of chronic pain patients undergoing such assessments...
July 17, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28715659/fetal-heart-rate-variation-after-corticosteroids-for-fetal-maturation
#7
Olga Knaven, Wessel Ganzevoort, Marjon de Boer, Hans Wolf
INTRODUCTION: Several studies report a decrease of fetal heart rate (FHR) short-term variation (STV) after corticosteroids for improvement of fetal maturity and advice not to deliver a fetus for low STV within 2-3days after corticosteroids. However, literature is not unanimous in this respect. This study intends to asses STV longitudinally after corticosteroid administration. MATERIAL AND METHODS: A retrospective cohort study in a tertiary perinatal centre from 2009 to 2015 included all women who had been treated with corticosteroids at gestational age of 26-34 weeks, had a computerized cardiotocography (cCTG) before and after medication and did not deliver within 48h...
June 29, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28713770/prognostic-impact-of-ajcc-uicc-8th-edition-new-staging-rules-in-oropharyngeal-squamous-cell-carcinoma
#8
Nora Würdemann, Steffen Wagner, Shachi Jenny Sharma, Elena-Sophie Prigge, Miriam Reuschenbach, Stefan Gattenlöhner, Jens Peter Klussmann, Claus Wittekindt
INTRODUCTION: The purpose of this study was to test whether the 8th edition of the AJCC/UICC TNM staging system (UICC) precisely differentiates between stages and reflects disease outcome in human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). PATIENTS AND METHODS: OPSCC patients that were diagnosed between 2000 and 2016 were included in this analysis and HPV status was determined by combined DNA and p16 testing. Stratification was done according to 7th and 8th UICC staging rules...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28713200/spatio-temporal-precipitation-climatology-over-complex-terrain-using-a-censored-additive-regression-model
#9
Reto Stauffer, Georg J Mayr, Jakob W Messner, Nikolaus Umlauf, Achim Zeileis
Flexible spatio-temporal models are widely used to create reliable and accurate estimates for precipitation climatologies. Most models are based on square root transformed monthly or annual means, where a normal distribution seems to be appropriate. This assumption becomes invalid on a daily time scale as the observations involve large fractions of zero observations and are limited to non-negative values. We develop a novel spatio-temporal model to estimate the full climatological distribution of precipitation on a daily time scale over complex terrain using a left-censored normal distribution...
June 15, 2017: International Journal of Climatology: a Journal of the Royal Meteorological Society
https://www.readbyqxmd.com/read/28710840/characterization-of-scientific-studies-usually-cited-as-evidence-of-adverse-effects-of-gm-food-feed
#10
REVIEW
M A Sánchez, W A Parrott
GM crops are the most studied crops in history. Approximately 5% of the safety studies on them show adverse effects that are a cause for concern, and tend to be featured in media reports. Although these reports are based on just a handful of GM events, they are used to cast doubt on all GM crops. Furthermore, they tend to come from just a few laboratories and are published in less important journals. Importantly, a close examination of these reports invariably shows methodological flaws that invalidate any conclusions of adverse effects...
July 15, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28703808/rip3-attenuates-the-pancreatic-damage-induced-by-deletion-of-atg7
#11
Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert, Franco Fortunato
Invalidation of pancreatic autophagy entails pancreatic atrophy, endocrine and exocrine insufficiency and pancreatitis. The aim of this study was to investigate whether depletion of Rip3, which is involved in necroptotic signaling, may attenuate the pancreatic atrophy and pancreatitis resulting from autophagy inhibition. Autophagy and necroptosis signaling were evaluated in mice lacking expression of Rip3 in all organs and Atg7 in the pancreas. Acinar cell death, inflammation and fibrosis were evaluated by using of a compendium of immunofluorescence methods and immunoblots...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28701935/cardiorespiratory-fitness-is-associated-with-selective-attention-in-healthy-male-high-school-students
#12
Eivind Wengaard, Morten Kristoffersen, Anette Harris, Hilde Gundersen
Background: Previous studies have shown associations of physical fitness and cognition in children and in younger and older adults. However, knowledge about associations in high-school adolescents and young adults is sparse. Thus, the aim of this study was to evaluate the association of physical fitness, measured as maximal oxygen uptake ([Formula: see text]), muscle mass, weekly training, and cognitive function in the executive domains of selective attention and inhibitory control, in healthy male high-school students...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28700443/assessment-of-conflicts-of-interest-in-robotic-surgical-studies-validating-author-s-declarations-with-the-open-payments-database
#13
Sunil V Patel, David Yu, Basheer Elsolh, Ben M Goldacre, Garrett M Nash
BACKGROUND: Accurate conflict of interest (COI) statements are important, as a known COI may invalidate study results due to the potential risk of bias. OBJECTIVE: To determine the accuracy of self-declared COI statements in robotic studies and identify risk factors for undeclared payments. METHODS: Robotic surgery studies were identified through EMBASE and MEDLINE and included if published in 2015 and had at least one American author. Undeclared COI were determined by comparing the author's declared COI with industry reported payments found in the "Open Payments" database for 2013 and 2014...
July 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28699206/kiaa1199-a-novel-regulator-of-mek-erk-induced-schwann-cell-dedifferentiation
#14
Angélique Boerboom, Céline Reusch, Alexandra Pieltain, Alain Chariot, Rachelle Franzen
The molecular mechanisms that regulate Schwann cell (SC) plasticity and the role of the Nrg1/ErbB-induced MEK1/ERK1/2 signalling pathway in SC dedifferentiation or in myelination remain unclear. It is currently believed that different levels of MEK1/ERK1/2 activation define the state of SC differentiation. Thus, the identification of new regulators of MEK1/ERK1/2 signalling could help to decipher the context-specific aspects driving the effects of this pathway on SC plasticity. In this perspective, we have investigated the potential role of KIAA1199, a protein that promotes ErbB and MEK1/ERK1/2 signalling in cancer cells, in SC plasticity...
July 12, 2017: Glia
https://www.readbyqxmd.com/read/28696386/analytic-and-diagnostic-performances-of-human-papillomavirus-e6-e7-mrna-test-on-up-to-11-year-old-liquid-based-cervical-samples-a-biobank-based-longitudinal-study
#15
Roberta Zappacosta, Francesca Sablone, Lucia Pansa, Davide Buca, Danilo Buca, Sandra Rosini
Human Papillomavirus (HPV) E6/E7 mRNA test demonstrated high specificity in detecting HPV infections, but studies assessing its efficacy in terms of cancer risk stratification are lacking. Follow-up studies are arduous and expensive. Biobank would be the answer to the problem, although data investigating the effects of long-term storage on RNA preservation are still needed. We addressed these issues by retrieving 202 residual liquid-based cervical specimens, collected from 149 women attending cervical cancer screening during the years 2001-2012...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28691413/diagnostic-challenges-in-celiac-disease
#16
REVIEW
Karol Kowalski, Agata Mulak, Maria Jasińska, Leszek Paradowski
Diagnosis of celiac disease in adults is currently based on serologic tests in combination with histopathological assessment of small intestinal biopsy specimens. High titers of celiac-specific antibodies in immunocompetent patients with villous atrophy in a good quality biopsy sample allow to state confident diagnosis. Relive of symptoms and histological improvement after embarking on a gluten free diet further support initial diagnosis. However, in some cases, these conditions are not fulfilled what requires critical evaluation of laboratory and histopathology results and consideration of other potential causes for observed pathologies...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28688730/use-of-medical-orders-for-scope-of-treatment-for-heart-failure-patients-during-postacute-care-in-skilled-nursing-facilities
#17
Hillary Lum, Oluyomi Obafemi, Joanna Dukes, Molly Nowels, Kristina Samon, Rebecca S Boxer
BACKGROUND: Individuals with heart failure (HF) who are hospitalized and admitted to skilled nursing facilities (SNFs) are at high risk for rehospitalization and death. The care preferences of this high-risk population have not been studied. OBJECTIVES: To describe care preferences of patients with HF admitted to SNFs for rehabilitation based on Medical Orders for Scope of Treatment (MOST) documentation, and evaluate goal-concordant care based on MOST documentation, emergency department (ED) visits, and hospitalization...
July 6, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28686635/visuo-spatial-cueing-in-children-with-differential-reading-and-spelling-profiles
#18
Chiara Banfi, Ferenc Kemény, Melanie Gangl, Gerd Schulte-Körne, Kristina Moll, Karin Landerl
Dyslexia has been claimed to be causally related to deficits in visuo-spatial attention. In particular, inefficient shifting of visual attention during spatial cueing paradigms is assumed to be associated with problems in graphemic parsing during sublexical reading. The current study investigated visuo-spatial attention performance in an exogenous cueing paradigm in a large sample (N = 191) of third and fourth graders with different reading and spelling profiles (controls, isolated reading deficit, isolated spelling deficit, combined deficit in reading and spelling)...
2017: PloS One
https://www.readbyqxmd.com/read/28686378/-common-benign-lesions-of-the-vocal-fold-diagnostic-criteria-and-management
#19
Anne-Claude Guinchard, Valérie Schweizer
The vocal cord or vocal fold is a remarkable structure, capable to support significant physical constraints. When the voice malmenage becomes chronic, it may appear an organic alteration causing nodules, polyps or Reinke edema even a lesion of the posterior glottis, the granuloma. These lesions are benign but lead to dysphonia that can be invalidating. Treatment can be a speech therapy with correction of breath and posture and, in some cases, a surgical treatment. In this article, we describe these common lesions with their histological characteristics and pathophysiological hypotheses which lead to their appearance and treatment...
October 5, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28686147/surgical-management-of-spinal-osteoblastomas
#20
Anne L Versteeg, Nicolas Dea, Stefano Boriani, Peter P Varga, Alessandro Luzzati, Michael G Fehlings, Mark H Bilsky, Laurence D Rhines, Jeremy J Reynolds, Mark B Dekutoski, Ziya L Gokaslan, Niccole M Germscheid, Charles G Fisher
OBJECTIVE Osteoblastoma is a rare primary benign bone tumor with a predilection for the spinal column. Although of benign origin, osteoblastomas tend to behave more aggressively clinically than other benign tumors. Because of the low incidence of osteoblastomas, evidence-based treatment guidelines and high-quality research are lacking, which has resulted in inconsistent treatment. The goal of this study was to determine whether application of the Enneking classification in the management of spinal osteoblastomas influences local recurrence and survival time...
July 7, 2017: Journal of Neurosurgery. Spine
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