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https://www.readbyqxmd.com/read/28340227/transplant-as-a-competing-risk-in-the-analysis-of-dialysis-patients
#1
Nan van Geloven, Saskia le Cessie, Friedo W Dekker, Hein Putter
Time-to-event analyses are frequently used in nephrology research, for instance, when recording time to death or time to peritonitis in dialysis patients. Many papers have pointed out the important issue of competing events (or competing risks) in such analyses. For example, when studying one particular cause of death it can be noted that patients also die from other causes. Such competing events preclude the event of interest from occurring and thereby complicate the statistical analysis. The Kaplan-Meier approach to calculating the cumulative probability of the event of interest yields invalid results in the presence of competing risks, thus the alternative cumulative incidence competing risk (CICR) approach has become the standard...
March 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28334223/is-bamm-flawed-theoretical-and-practical-concerns-in-the-analysis-of-multi-rate-diversification-models
#2
Daniel L Rabosky, Jonathan S Mitchell, Jonathan Chang
BAMM (Bayesian Analysis of Macroevolutionary Mixtures) is a statistical framework that uses reversible jump MCMC to infer complex macroevolutionary dynamics of diversification and phenotypic evolution on phylogenetic trees. A recent article by Moore and coauthors (MEA) reported a number of theoretical and practical concerns with BAMM. Major claims from MEA are that (1) BAMM's likelihood function is incorrect, because it does not account for unobserved rate shifts; (2) the posterior distribution on the number of rate shifts is overly sensitive to the prior; and (3) diversification rate estimates from BAMM are unreliable...
February 21, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28330726/provision-of-physiological-data-and-reference-values-in-awake-and-anaesthetized-female-sheep-aged-6-12-months
#3
Tim Kampmeier, Philip Arnemann, Michael Heßler, Sebastian Rehberg, Andrea Morelli, Martin Westphal, Matthias Lange, Hugo Van Aken, Christian Ertmer
OBJECTIVE: To provide physiological data and reference values in awake and anaesthetized sheep aged 6-12 months. STUDY DESIGN: Descriptive study. ANIMALS: Data from 260 female sheep of the species Ovis orientalis aries aged 6-12 months were extracted from 10 experimental trials. METHODS: Data from pulmonary arterial thermodilution in awake (cohort 1; n = 109) and anaesthetized animals (cohort 2; n = 81), and transpulmonary thermodilution in anaesthetized animals (cohort 3; n = 70) were analysed...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28329916/online-support-for-transgender-people-an-analysis-of-forums-and-social-networks
#4
Sabrina Cipolletta, Riccardo Votadoro, Elena Faccio
Transgender people face a range of personal and social conflicts that strongly influence their well-being. In many cases, the Internet can become the main resource in terms of finding support. The aim of this study was to understand how transgender people give and receive help online. Between 2013 and 2015, 122 online community conversations were collected on Italian forums and Facebook groups involving transgender people, and online interviews were conducted with 16 users of these communities. A qualitative content analysis was conducted by using the software package, NVivo10...
March 22, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28327131/transcriptome-analysis-of-pancreatic-cells-across-distant-species-highlights-novel-important-regulator-genes
#5
Estefania Tarifeño-Saldivia, Arnaud Lavergne, Alice Bernard, Keerthana Padamata, David Bergemann, Marianne L Voz, Isabelle Manfroid, Bernard Peers
BACKGROUND: Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the function of the different pancreatic cell types has been maintained during vertebrate evolution, the comparison of their transcriptomes across distant vertebrate species is a means to pinpoint genes under strong evolutionary constraints due to their crucial function, which have therefore preserved their selective expression in these pancreatic cell types...
March 21, 2017: BMC Biology
https://www.readbyqxmd.com/read/28325916/automatic-time-shift-alignment-method-for-chromatographic-data-analysis
#6
Qing-Xia Zheng, Hai-Yan Fu, He-Dong Li, Bing Wang, Cui-Hua Peng, Sheng Wang, Jun-Lan Cai, Shao-Feng Liu, Xiao-Bing Zhang, Yong-Jie Yu
Time shift among samples remains a significant challenge in data analysis, such as quality control of natural plant extracts and metabolic profiling analysis, because this phenomenon may lead to invalid conclusions. In this work, we propose a new time shift alignment method, namely, automatic time-shift alignment (ATSA), for complicated chromatographic data analysis. This technique comprised the following alignment stages: (1) automatic baseline correction and peak detection stage for providing useful chromatographic information; (2) preliminary alignment stage through adaptive segment partition to correct alignment for the entire chromatogram; and (3) precise alignment stage based on test chromatographic peak information to accurately align time shift...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28324927/estimation-of-arterio-venous-access-blood-flow-in-hemodialysis-patients-using-video-image-processing-technique
#7
Fansan Zhu, Schantel Williams, Hannah Putnam, Israel Campos, Jie Ma, Camille Johnson, Franz Kappel, Peter Kotanko
Assessment of arterio-venous fistula (AVF) blood flow (ABF) is vital in hemodialysis (HD) patients. Currently, no non-invasive and contact-free technique is available to accurately measure ABF in routine clinical practice. In this study, we developed a novel approach using video image processing (VIP) to measure the change in optic flow in the skin. We the tested the hypothesis that the change in optical flow, expressed as the change in pixels between consecutive frames, is related to ABF. We recorded AVF videos in 40 HD patients using a digital camera and processed them by VIP technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28321249/mexican-hat-wavelet-kernel-elm-for-multiclass-classification
#8
Jie Wang, Yi-Fan Song, Tian-Lei Ma
Kernel extreme learning machine (KELM) is a novel feedforward neural network, which is widely used in classification problems. To some extent, it solves the existing problems of the invalid nodes and the large computational complexity in ELM. However, the traditional KELM classifier usually has a low test accuracy when it faces multiclass classification problems. In order to solve the above problem, a new classifier, Mexican Hat wavelet KELM classifier, is proposed in this paper. The proposed classifier successfully improves the training accuracy and reduces the training time in the multiclass classification problems...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28321187/steps-to-health-in-cognitive-aging-effects-of-physical-activity-on-spatial-attention-and-executive-control-in-the-elderly
#9
Giancarlo Condello, Roberta Forte, Simone Falbo, John B Shea, Angela Di Baldassarre, Laura Capranica, Caterina Pesce
The purpose of this study was to investigate whether physical activity (PA) habits may positively impact performance of the orienting and executive control networks in community-dwelling aging individuals and diabetics, who are at risk of cognitive dysfunction. To this aim, we tested cross-sectionally whether age, ranging from late middle-age to old adulthood, and PA level independently or interactively predict different facets of the attentional performance. Hundred and thirty female and male individuals and 22 adults with type 2 diabetes aged 55-84 years were recruited and their daily PA (steps) was objectively measured by means of armband monitors...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28318967/pitch-strength-as-an-outcome-measure-for-treatment-of-dysphonia
#10
Lisa M Kopf, Cristina Jackson-Menaldi, Adam D Rubin, Jean Skeffington, Eric J Hunter, Mark D Skowronski, Rahul Shrivastav
BACKGROUND: Measurement of treatment outcomes is critical for the spectrum of voice treatments (ie, surgical, behavioral, or pharmacological). Outcome measures typically include visual (eg, stroboscopic data), auditory (eg, Consensus Auditory-Perceptual Evaluation of Voice; Grade, Roughness, Breathiness, Asthenia, Strain), and objective correlates of vocal fold vibratory characteristics, such as acoustic signals (eg, harmonics-to-noise ratio, cepstral peak prominence) or patient self-reported questionnaires (eg, Voice Handicap Index, Voice-Related Quality of Life)...
March 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28317118/accuracy-of-self-esteem-judgments-at-zero-acquaintance
#11
Sarah Hirschmüller, Stefan C Schmukle, Sascha Krause, Mitja D Back, Boris Egloff
OBJECTIVE: Perceptions of strangers' self-esteem can have wide-ranging interpersonal consequences. Aiming to reconcile inconsistent results from previous research that had predominantly suggested that self-esteem is a trait that can hardly be accurately judged at zero acquaintance, we examined unaquainted others' accuracy in inferring individuals' actual self-esteem. METHOD: Ninety-nine participants were videotaped in a self-introductory situation, and self-esteem self-reports and reports by well-known informants were obtained as separate accuracy criteria...
March 20, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28314818/allometric-analysis-detects-brain-size-independent-effects-of-sex-and-sex-chromosome-complement-on-human-cerebellar-organization
#12
Catherine Mankiw, Min Tae M Park, P K Reardon, Ari M Fish, Liv S Clasen, Deanna Greenstein, Jay N Giedd, Jonathan D Blumenthal, Jason P Lerch, M Mallar Chakravarty, Armin Raznahan
The cerebellum is a large hindbrain structure that is increasingly recognized for its contribution to diverse domains of cognitive and affective processing in human health and disease. Although several of these domains are sex-biased, our fundamental understanding of cerebellar sex differences - including their spatial distribution, potential biological determinants, and independence from brain volume variation - lags far behind that for the cerebrum. Here, we harness automated neuroimaging methods for cerebellar morphometrics in 417 individuals to (i) localize normative male-female differences in raw cerebellar volume, (ii) compare these to sex chromosome effects estimated across five rare X-/Y-chromosome aneuploidy (SCA) syndromes, and (iii) clarify brain size-independent effects of sex and SCA on cerebellar anatomy using a generalizable allometric approach which considers scaling relationships between regional cerebellar volume and brain volume in health...
March 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28306349/utility-of-critical-items-within-the-recognition-memory-test-and-word-choice-test
#13
Laszlo A Erdodi, Bradley T Tyson, Christopher A Abeare, Brandon G Zuccato, Jaspreet K Rai, Kristian R Seke, Sanya Sagar, Robert M Roth
This study was designed to examine the clinical utility of critical items within the Recognition Memory Test (RMT) and the Word Choice Test (WCT). Archival data were collected from a mixed clinical sample of 202 patients clinically referred for neuropsychological testing (54.5% male; mean age = 45.3 years; mean level of education = 13.9 years). The credibility of a given response set was psychometrically defined using three separate composite measures, each of which was based on multiple independent performance validity indicators...
March 17, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28302725/ankyrin-repeat-and-zinc-finger-domain-containing-1-mutations-are-associated-with-infantile-onset-inflammatory-bowel-disease
#14
Désirée Y van Haaften-Visser, Magdalena Harakalova, Enric Mocholi, Joris M van Montfrans, Abdul Elkadri, Ester Rieter, Karoline Fiedler, Peter M van Hasselt, Emily M M Triffaux, Mieke M van Haelst, Isaac J Nijman, Wigard P Kloosterman, Edward E S Nieuwenhuis, Aleixo M Muise, Edwin Cuppen, Roderick H J Houwen, Paul J Coffer
Infantile-onset inflammatory bowel disease (IO IBD) is an invalidating illness with an onset before two years of age and has a complex pathophysiology in which genetic factors are important. Homozygosity mapping and whole exome sequencing in an IO IBD patient and subsequent sequencing of the candidate gene in twelve additional IO IBD patients revealed two patients with two mutated Ankyrin Repeat and Zinc Finger Domain containing 1 (ANKZF1) alleles (homozygous ANKZF1 R585Q mutation and compound heterozygous ANKZF1 E152K and V32_Q87del mutations respectively) and two patients with one mutated ANKZF1 allele...
March 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28297274/validation-of-an-improved-helical-diode-array-and-dose-reconstruction-software-using-tg-244-datasets-and-stringent-dose-comparison-criteria
#15
Saeed Ahmed, Benjamin Nelms, Jakub Kozelka, Geoffrey Zhang, Eduardo Moros, Vladimir Feygelman
The original helical ArcCHECK (AC) diode array and associated software for 3D measurement-guided dose reconstruction were characterized and validated; however, recent design changes to the AC required that the subject be revisited. The most important AC change starting in 2014 was a significant reduction in the overresponse of diodes to scattered radiation outside of the direct beam, accomplished by reducing the amount of high-Z materials adjacent to the diodes. This change improved the diode measurement accuracy, but in the process invalidated the dose reconstruction models that were assembled based on measured data acquired with the older version of the AC...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296628/struggles-for-medical-legitimacy-among-women-experiencing-sexual-pain-a-qualitative-study
#16
Amy Braksmajer
Given the prominent role of medical institutions in defining what is "healthy" and "normal", many women turn to medicine when experiencing pain during intercourse (dyspareunia). The medical encounter can become a contest between patients and providers when physicians do not grant legitimacy to patients' claims of illness. Drawing on interviews conducted from 2007-2008 and 2011-2012 with 32 women with dyspareunia (ages 18-60 years) living in New York City and surrounding areas, this study examined women's and their physicians' claims regarding bodily expertise, particularly women's perceptions of physician invalidation, their understanding of this invalidation as gendered, and the consequences for women's pursuit of medicalization...
March 15, 2017: Women & Health
https://www.readbyqxmd.com/read/28293676/how-much-gk-is-in-the-nklm-a-comparison-between-the-catalogues-of-exam-relevant-topics-gk-and-the-german-national-competence-based-learning-objectives-catalogue-for-undergraduate-medical-education-nklm
#17
Olaf Fritze, Jan Griewatz, Elisabeth Narciß, Thomas Shiozawa, Annette Wosnik, Stephan Zipfel, Maria Lammerding-Koeppel
Background: The German National Competence-Based Learning Objectives for Undergraduate Medical Education (NKLM) being adopted in 2015 is designed to contribute to improve the quality of teaching and learning in medicine with respect to competence orientation. For departments, the coherence between teaching, assessment and the content of the catalogues of exam-relevant topics (GK) is a crucial factor. Before making use of the NKLM seriously in curricular development, many faculties demand more transparency regarding the representation in the NKLM of GK topics and in what aspects the NKLM exceeds the GK...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28291039/performance-validity-testing-in-neuropsychology-scientific-basis-and-clinical-application-a-brief-review
#18
Michael R Greher, Thomas R Wodushek
Performance validity testing refers to neuropsychologists' methodology for determining whether neuropsychological test performances completed in the course of an evaluation are valid (ie, the results of true neurocognitive function) or invalid (ie, overly impacted by the patient's effort/engagement in testing). This determination relies upon the use of either standalone tests designed for this sole purpose, or specific scores/indicators embedded within traditional neuropsychological measures that have demonstrated this utility...
March 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28285755/-the-human-and-economic-burden-of-cancer-in-france-in-2014-based-on-the-sniiram-national-database
#19
Philippe Tuppin, Laurence Pestel, Solène Samson, Anne Cuerq, Sébastien Rivière, Stéphane Tala, Pierre Denis, Jérôme Drouin, Claude Gissot, Christelle Gastaldi-Ménager, Anne Fagot-Campagna
INTRODUCTION: The national health insurance information system (Sniiram) can be used to estimate the national medical and economic burden of cancer. This study reports the annual rates, characteristics and expenditure of people reimbursed for cancer. METHODS: Among 57 million general health scheme beneficiaries (86% of the French population), people managed for cancer were identified using algorithms based on hospital diagnoses and full refund for long-term cancer...
March 9, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28285575/the-power-of-timing-adding-a-time-to-completion-cutoff-to-the-word-choice-test-and-recognition-memory-test-improves-classification-accuracy
#20
Laszlo A Erdodi, Bradley T Tyson, Ayman G Shahein, Jonathan D Lichtenstein, Christopher A Abeare, Chantalle L Pelletier, Brandon G Zuccato, Brittany Kucharski, Robert M Roth
INTRODUCTION: The Recognition Memory Test (RMT) and Word Choice Test (WCT) are structurally similar, but psychometrically different. Previous research demonstrated that adding a time-to-completion cutoff improved the classification accuracy of the RMT. However, the contribution of WCT time-cutoffs to improve the detection of invalid responding has not been investigated. The present study was designed to evaluate the classification accuracy of time-to-completion on the WCT compared to the accuracy score and the RMT...
May 2017: Journal of Clinical and Experimental Neuropsychology
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