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https://www.readbyqxmd.com/read/28639119/a-pharmacokinetic-drug-drug-interaction-study-between-selexipag-and-midazolam-a-cyp3a4-substrate-in-healthy-male-subjects
#1
Pierre-Eric Juif, Margaux Boehler, Yves Donazzolo, Shirin Bruderer, Jasper Dingemanse
PURPOSE: In vitro data showed that selexipag and its active metabolite (ACT-333679) have an inductive effect on CYP3A4, CYP2B6, and CYP2C9 at concentrations approximately 100-fold higher than the maximum plasma concentration (C max) measured under steady-state conditions. In order to confirm in vivo the lack of induction at the enterocyte level, we assessed the effect of selexipag on midazolam, a substrate of hepatic and intestinal CYP3A4. METHODS: This study was conducted according to an open-label, randomized, two-way crossover design...
June 21, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28638708/citation-classics-in-central-nervous-system-inflammatory-demyelinating-disease
#2
Jee-Eun Kim, Kang M Park, Yerim Kim, Dae Y Yoon, Jong S Bae
OBJECTIVES: To identify and analyze the characteristics of the most influential articles about central nervous system (CNS) inflammatory demyelinating disease. MATERIALS AND METHODS: The Institute for Scientific Information (ISI) Web of Science database and the 2014 Journal Citation Reports Science Edition were used to retrieve the top 100 cited articles on CNS inflammatory demyelinating disease. The citation numbers, journals, years of publication, authorships, article types, subjects and main issues were analyzed...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28629365/evaluation-and-improvement-of-the-regulatory-inference-for-large-co-expression-networks-with-limited-sample-size
#3
Wenbin Guo, Cristiane P G Calixto, Nikoleta Tzioutziou, Ping Lin, Robbie Waugh, John W S Brown, Runxuan Zhang
BACKGROUND: Co-expression has been widely used to identify novel regulatory relationships using high throughput measurements, such as microarray and RNA-seq data. Evaluation studies on co-expression network analysis methods mostly focus on networks of small or medium size of up to a few hundred nodes. For large networks, simulated expression data usually consist of hundreds or thousands of profiles with different perturbations or knock-outs, which is uncommon in real experiments due to their cost and the amount of work required...
June 19, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28628835/low-frequency-sonic-waves-assisted-cloud-point-extraction-of-polyhydroxyalkanoate-from-cupriavidus-necator
#4
Sivananth Murugesan, Regupathi Iyyaswami
Low frequency sonic waves, less than 10kHz were introduced to assist cloud point extraction of polyhydroxyalkanoate from Cupriavidus necator present within the crude broth. Process parameters including surfactant system variables and sonication parameters were studied for their effect on extraction efficiency. Introduction of low frequency sonic waves assists in the dissolution of microbial cell wall by the surfactant micelles and release of cellular content, polyhydroxyalkanoate granules released were encapsulated by the micelle core which was confirmed by crotonic acid assay...
June 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28627535/a-first-principles-study-on-the-adsorption-of-ethylenediamine-on-ge-100
#5
Do Hwan Kim, Suklyun Hong
We have performed density functional theory (DFT) calculations of the atomic and electronic structures of ethylenediamine on Ge(100). The two amine groups in ethylenediamine can interact with germanium surface atoms through a N-H dissociative nucleophilic reaction and/or N-dative bonding with an electron-deficient down Ge atom. Of the monodentate and row-bridged bidentate structures that formed, the dative-bonded configurations were found to be more stable than the NH dissociative adsorption structures. The formation of row-bridged bidentate, structures is more favorable than that of on-top or end-bridged structures...
June 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28621026/low-density-open-cellular-sponges-as-functional-materials
#6
Shaohua Jiang, Seema Agarwal, Andreas Greiner
Low density macroporous sponges with densities less than 100 mg cm-3 are a challenge and an opportunity in advanced chemistry and material science. The challenge lies in the precise preparation of the sponges with property combinations that lead to novel applications. Bottom-up and top-down chemi-cal and engineering methods for preparation are a major focus of this review, with an emphasis on carbon and polymer materi-als. Light weight, sustainability, breathability, special wetting characteristics, large mass transfer, mechanical stability, and large pore volume are typical characteristics of sponges made of advanced materials and could lead to novel applications...
June 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28617352/equivalent-circuit-model-of-low-frequency-magnetoelectric-effect-in-disk-type-terfenol-d-pzt-laminate-composites-considering-a-new-interface-coupling-factor
#7
Guofeng Lou, Xinjie Yu, Shihua Lu
This paper describes the modeling of magnetoelectric (ME) effects for disk-type Terfenol-D (Tb0.3Dy0.7Fe1.92)/PZT (Pb(Zr,Ti)O₃) laminate composite at low frequency by combining the advantages of the static elastic model and the equivalent circuit model, aiming at providing a guidance for the design and fabrication of the sensors based on magnetoelectric laminate composite. Considering that the strains of the magnetostrictive and piezoelectric layers are not equal in actual operating due to the epoxy resin adhesive bonding condition, the magnetostrictive and piezoelectric layers were first modeled through the equation of motion separately, and then coupled together with a new interface coupling factor kc, which physically reflects the strain transfer between the phases...
June 15, 2017: Sensors
https://www.readbyqxmd.com/read/28612945/comparative-study-of-the-number-of-report-and-time-to-onset-of-the-reported-adverse-event-between-the-biosimilars-and-the-originator-of-filgrastim
#8
Tetsu Kobayashi, Izumi Kamada, Junko Komura, Satoshi Toyoshima, Akiko Ishii-Watabe
PURPOSE: The objective of this study is to specify the most reported adverse events as preferred terms (PTs) and to compare the reported adverse events about some properties including the number of report and time-to-onset (TTO) distribution of the originator of filgrastim Neupogen® and its biosimilars in Europe, using VigiBase®. METHODS: We identified the biosimilar which was reported as the suspected drug in more than 100 individual case safety reports in Europe...
June 14, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28607492/cognitive-characterization-of-schizophrenia-risk-variants-involved-in-synaptic-transmission-evidence-of-cacna1c-s-role-in-working-memory
#9
Donna Cosgrove, Omar Mothersill, Kimberley Kendall, Bettina Konte, Denise Harold, Ina Giegling, Annette Hartmann, Alex Richards, Kiran Mantripragada, Michael J Owen, Michael C O'Donovan, Michael Gill, Dan Rujescu, James Walters, Aiden Corvin, Derek W Morris, Gary Donohoe
With >100 common variants associated with schizophrenia risk, establishing their biological significance is a priority. We sought to establish cognitive effects of risk variants at loci implicated in synaptic transmission by (1) identifying GWAS schizophrenia variants whose associated gene function is related to synaptic transmission, and (2) testing for association between these and measures of neurocognitive function. We selected variants, reported in the largest GWAS to date, associated with genes involved in synaptic transmission...
June 13, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28604369/selective-area-growth-of-aln-gan-nanocolumns-on-0001-and-11-22-gan-sapphire-for-semi-polar-and-non-polar-aln-pseudo-templates
#10
Ana Bengoechea Encabo, Steven Albert, Marcus Müller, Mengyao Xie, Peter Veit, Frank Bertram, Miguel Sanchez-Garcia, Jesus Zuniga-Perez, Philippe de Mierry, Juergen Christen, Enrique Calleja
Despite the strong interest in optoelectronic devices working in the deep ultraviolet range, no suitable low cost, large-area, high-quality AlN substrates are available up to now. The aim of this work is the selective area growth of AlN nanocolumns by plasma assisted molecular beam epitaxy on polar (0001) and semi-polar (11-22) GaN/sapphire templates. The resulting AlN nanocolumns are vertically oriented with semi-polar {1-103} top facets when grown on (0001) GaN/sapphire, or oriented at 58° from the template normal and exposing {1-100} non-polar top facets when growing on (11-22) GaN/sapphire, in both cases reaching filling factors ≥ 80 %...
June 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28600106/genetic-analysis-of-mayer-rokitansky-kuster-hauser-syndrome-in-a-large-cohort-of-families
#11
Lacey S Williams, Durkadin Demir Eksi, Yiping Shen, Amy C Lossie, Lynn P Chorich, Megan E Sullivan, John A Phillips, Munire Erman, Hyung-Goo Kim, Ozgul M Alper, Lawrence C Layman
OBJECTIVE: To study the genetic cause of Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH). Although a few candidate genes and genomic domains for have been reported for MRKH, the genetic underpinnings remain largely unknown. Some of the top candidate genes are WNT4, HNF1B, and LHX1. The goals of this study were to: 1) determine the prevalence of WNT4, HNF1B, and LHX1 point mutations, as well as new copy number variants (CNVs) in people with MRKH; and 2) identify and characterize MRKH cohorts...
June 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28599363/ranking-traditional-and-nano-enabled-sorbents-for-simultaneous-removal-of-arsenic-and-chromium-from-simulated-groundwater
#12
Mac Gifford, Kiril Hristovski, Paul Westerhoff
Water from many municipal and private wells are treated to meet arsenic (As(V)) regulations, and new regulations for hexavalent chromium (Cr(VI)) are soon possible. Rather than adding costly capital infrastructure, we explored many types of sorbents' ability to remove both oxygenated anions simultaneously. In laboratory pseudo-equilibrium tests, metal (hydr)oxide sorbents demonstrated high affinity for As(V) but exhibited 30 to 100-fold lower capacities to remove Cr(VI). WBAX resins had some ability to sorb both Cr(VI) and As(V), but competing anions lowered their sorption capacity for As(V) by >90% compared to in a deionized water matrix...
June 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28599194/spatiotemporal-patterns-and-relationships-among-the-diet-biochemistry-and-exposure-to-flame-retardants-in-an-apex-avian-predator-the-peregrine-falcon
#13
Kim J Fernie, Dominique Chabot, Louise Champoux, Samantha Brimble, Mehran Alaee, Sarah Marteinson, Da Chen, Vince Palace, David M Bird, Robert J Letcher
Flame retardants (FR) are industrial chemicals and some are proven environmental contaminants that accumulate in predatory birds. Few studies have examined the influence of diet on FR profiles in nestling raptors and the possible physiological implications of such FR exposure. The objectives of this research were (1) to determine spatial patterns of ≤ 48 polybrominated diphenyl ether (PBDE) congeners and ≤ 26 non-PBDE FRs, including organophosphate esters (OPEs), in nestling peregrine falcons (Falco peregrinus) across the Canadian Great Lakes-St...
June 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/28597442/effects-of-adjacent-land-use-types-on-the-distribution-of-soil-organic-carbon-stocks-in-the-montane-area-of-central-taiwan
#14
Chiou-Pin Chen, Kai-Wei Juang, Chih-Hsin Cheng, Chuang-Wen Pai
BACKGROUND: Soil organic carbon (SOC) stocks can be altered through reforestation and cropping. We estimated the effects of land use on SOC stocks after natural deciduous forests replaced by crops and coniferous plantations by examining the vertical distribution of SOC stocks at different depth intervals in an adjacent Oolong tea (Camellia sinensis L.) plantation, Moso bamboo (Phyllostachys pubescens) forest, Japanese cedar (Cryptomeria japonica) forest, and Taiwania (Taiwania cryptomerioides) forest in central Taiwan...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28593538/physiological-and-biochemical-responses-of-machilus-ichangensis-rehd-et-wils-and-taxus-chinensis-pilger-rehd-to-elevated-o3-in-subtropical-china
#15
Hao Yu, Zhan Chen, He Shang, Jixin Cao
Considerable researches have documented the negative effects of ozone on woody species in North America and Europe; however, little is known about how woody tree species respond to elevated O3 in subtropical China, and most of the previous studies were conducted using pot experiment. In the present study, Machilus ichangensis Rehd. et Wils (M. ichangensis) and Taxus chinensis (Pilger) Rehd. (T. chinensis), evergreen tree species in subtropical China, were exposed to non-filtered air (NF), 100 nmol mol(-1) O3 (E1) and 150 nmol mol(-1) O3 (E2), in open-top chambers under field conditions from 21st March to 2nd November 2015...
June 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28592026/-clinical-analysis-of-therapeutic-bronchoscopy-for-tracheal-neoplasm
#16
Y F Ding, L Chen, H D Huang, Y C Dong, X P Yao, Y Huang, Q Wang, W Zhang, Q Li, C Bai
Objective: To analyze the clinical features in adults with tracheal neoplasm and to evaluate the efficacy of interventional bronchoscopic treatment. Methods: We retrospectively analyzed the clinical features of 43 adults undergoing therapeutic bronchoscopy for tracheal neoplasm diagnosed in Changhai Hospital affiliated to the Second Military Medical University from January 2004 to July 2014.The degree of stenosis, the grade of dyspnea, and Karnofsky performance status scale were evaluated before and after the last procedure...
June 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28586820/sodium-reduction-in-us-households-packaged-food-and-beverage-purchases-2000-to-2014
#17
Jennifer M Poti, Elizabeth K Dunford, Barry M Popkin
Importance: Initiatives to reduce sodium in packaged foods have been launched in the United States, yet corresponding changes in the amount of sodium that US households obtain from packaged foods have not been evaluated, to our knowledge. Objective: To assess 15-year changes in the amount of sodium that US households acquire from packaged food purchases, the sodium content of purchases, and the proportion of households that have purchases with optimal sodium density...
June 5, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28578279/microbial-stratification-structure-within-cathodic-biofilm-of-the-microbial-fuel-cell-using-the-freezing-microtome-method
#18
Xiao Li, Yaobin Lu, Haiping Luo, Guangli Liu, Renduo Zhang
The aim of this study was to investigate the microbial stratification structure within cathodic biofilm of the microbial fuel cell (MFC) using the freezing microtome method. Experiments were conducted in a single-chamber air-cathode MFC with 0.8g/L maltodextrin as substrate for ∼30d operation. The maximum power density was 945±10mW/m(2) in the MFC. Maltodextrin resulted in the relative abundance of Candidatus Saccharibacteria of 37.0% in the anodic biofilm. Different bacterial communities were identified in different layers within the cathodic biofilm...
May 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28574076/bushy-sphere-dendrites-with-husk-shaped-branches-axially-spreading-out-from-the-core-for-photo-catalytic-oxidation-remediation-of-toxins
#19
Mohamed A Shenashen, Satoshi Kawada, Mahmoud M Selim, Wafaa M Morsy, Hitoshi Yamaguchi, Abdulaziz A Alhamid, Naoki Ohashi, Izumi Ichinose, Sherif A El-Safty
This work describes densely interlinked bushy "tree-like chains" characterized by neatly branched sphere dendrites (bushy sphere dendrites, BSD) with long fan-like, husk-shaped branching paths that extend longitudinally from the core axis of the {110}-exposed plane. We confirmed that the hierarchical dendrite surfaces created bowls of swirled caves along the tree-tube in the mat-like branches. These surfaces had high-index catalytic site facets associated with the formation of ridges/defects on the dominant {110}-top-cover surface...
June 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28572925/origins-production-and-utilization-of-cassava-in-burkina-faso-a-contribution-of-a-neglected-crop-to-household-food-security
#20
Flibert Guira, Koussao Some, Donatien Kabore, Hagrétou Sawadogo-Lingani, Yves Traore, Aly Savadogo
Cassava (Manihot esculenta Crantz) is a food plant introduced in Africa from America by the Portuguese in 1558. The objective of this study is to establish cassava origins, production, and utilization in Burkina Faso. The investigation was carried out in the regions of Center West, Cascades, Boucle du Mouhoun, Hauts Bassins, South West, and Center East of Burkina Faso. Eighteen cassava processing units and 226 farmers in 57 communities from the selected regions have been involved in the survey. The investigation showed that cassava was introduced to Burkina Faso, former Upper Volta from the costal countries, Gold Coast (now Ghana), by both local traders and the Roman Catholic White missionaries...
May 2017: Food Science & Nutrition
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