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https://www.readbyqxmd.com/read/28326732/-three-dimensional-finite-element-analyses-of-the-deep-wedge-shaped-defective-premolars-restored-with-different-methods
#1
Zhao Ling, Yang Liyuan, Liu Cuiling, Gao Xu
OBJECTIVE: The objective of this paper is to analyze the stress distribution in the deep wedge-shaped defective mandibular first premolars restored with different methods. METHODS: Three-dimensional finite element models of mandibular first premolar with deep wedge-shaped defect were created. The model, which was untreated after root canal treatment, served as the control group. Then, according to different treatment designs, four experimental groups were established as follows: resin filling (A), post restoration after resin filling (B), crown restoration after resin filling (C), and post and crown restoration after resin filling (D)...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28321324/choosing-wisely-the-canadian-society-of-nephrology-s-list-of-5-items-physicians-and-patients-should-question
#2
Emilie Chan, Brenda Hemmelgarn, Scott Klarenbach, Braden Manns, Reem Mustafa, Gihad Nesrallah, Rory McQuillan
PURPOSE OF REVIEW: The purpose of this review is to contribute to the Choosing Wisely Canada campaign and develop a list of 5 items for nephrology health care professionals and patients to re-evaluate based on evidence that they are overused or misused. SOURCES OF INFORMATION: A working group was formed from the Canadian Society of Nephrology (CSN) Clinical Practice Guidelines Committee. This working group sequentially used a multistage Delphi method, a survey of CSN members, a modified Delphi process, and a comprehensive literature review to determine 10 candidate items representing potentially ineffective care in nephrology...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28320803/ranking-businesses-and-municipal-locations-by-spatiotemporal-cardiac-arrest-risk-to-guide-public-defibrillator-placement
#3
Christopher L F Sun, Steven C Brooks, Laurie J Morrison, Timothy C Y Chan
BACKGROUND: Efforts to guide automated external defibrillator placement for out-of-hospital cardiac arrest (OHCA) treatment have focused on identifying broadly defined location categories without considering hours of operation. Broad location categories may be composed of many businesses with varying accessibility. Identifying specific locations for automated external defibrillator deployment incorporating operating hours and time of OHCA occurrence may improve automated external defibrillator accessibility...
March 21, 2017: Circulation
https://www.readbyqxmd.com/read/28299688/all-electrical-graphene-dna-sensor-array
#4
Jeffrey Abbott, Donhee Ham, Guangyu Xu
Electrical sensing of biomolecules has been an important pursuit due to the label-free operation and chip-scale construct such sensing modality can enable. In particular, electrical biomolecular sensors based on nanomaterials such as semiconductor nanowires, carbon nanotubes, and graphene have demonstrated high sensitivity, which in the case of nanowires and carbon nanotubes can surpass typical optical detection sensitivity. Among these nanomaterials, graphene is well suited for a practical candidate for implementing a large-scale array of biomolecular sensors, as its two-dimensional morphology is readily compatible with industry standard top-down fabrication techniques...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28294373/rationale-and-design-of-reduce-it-reduction-of-cardiovascular-events-with-icosapent-ethyl-intervention-trial
#5
Deepak L Bhatt, Ph Gabriel Steg, Eliot A Brinton, Terry A Jacobson, Michael Miller, Jean-Claude Tardif, Steven B Ketchum, Ralph T Doyle, Sabina A Murphy, Paresh N Soni, Rene A Braeckman, Rebecca A Juliano, Christie M Ballantyne
Residual cardiovascular risk persists despite statins, yet outcome studies of lipid-targeted therapies beyond low-density lipoprotein cholesterol (LDL-C) have not demonstrated added benefit. Triglyceride elevation is an independent risk factor for cardiovascular events. High-dose eicosapentaenoic acid (EPA) reduces triglyceride-rich lipoproteins without raising LDL-C. Omega-3s have postulated pleiotropic cardioprotective benefits beyond triglyceride-lowering. To date, no large, multinational, randomized clinical trial has proved that lowering triglycerides on top of statin therapy improves cardiovascular outcomes...
March 15, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28292508/pharmacy-based-statewide-naloxone-distribution-a-novel-top-down-bottom-up-approach
#6
Kate J Morton, Brianna Harrand, Carly Cloud Floyd, Craig Schaefer, Julie Acosta, Bridget Claire Logan, Karen Clark
OBJECTIVE: To highlight New Mexico's multifaceted approach to widespread pharmacy naloxone distribution and to share the interventions as a tool for improving pharmacy-based naloxone practices in other states. SETTING: New Mexico had the second highest drug overdose death rate in 2014 of which 53% were related to prescription opioids. Opioid overdose death is preventable through the use of naloxone, a safe and effective medication that reverses the effects of prescription opioids and heroin...
March 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28291017/dft-and-tpd-study-of-the-role-of-steps-in-the-adsorption-of-co-on-copper-cu-410-vs-cu-100
#7
Anton Kokalj, Takamasa Makino, Michio Okada
Adsorption of carbon monoxide (CO) was studied on stepped Cu(410) by temperature programmed desorption (TPD) and density-functional-theory (DFT) calculations. For comparison, the adsorption of CO was characterized also on Cu(100) by DFT calculations. On Cu(410) TPD reveals two desorption peaks: a high temperature peak (∼210 K) is attributed to the desorption of CO from step-edge sites and low temperature peak (∼170 K) to desorption from terrace sites. According to DFT calculations, CO prefers to adsorb at step-edges of Cu(410), although the step-edge vs terrace site preference is rather small at low coverage of 1/16 ML, about 0...
March 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28290573/emerging-investigator-series-dual-role-of-organic-matter-in-the-anaerobic-degradation-of-triclosan
#8
Lin Wang, Shengnan Xu, Bo Pan, Yu Yang
Triclosan (TCS), one of the most widely used antimicrobial agents, has been listed among the top 10 contaminants in US rivers. Environmental persistence, endocrine disruption effects, and the antibiotic resistance induction capacity of TCS attract interest in its environmental fate and degradation. Herein, we found that TCS can be anaerobically degraded at pH 9 by a metal-reducing bacterium, Shewanella putrefaciens CN32. The degradation was substantially facilitated by low-concentration (0-15 mg C per L) organic matter (OM) extracted from a peat soil, whereas TCS degradation was inhibited by further increased concentration (15-100 mg C per L) of OM...
March 14, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28287523/use-of-sacrificial-nanoparticles-to-remove-the-effects-of-shot-noise-in-contact-holes-fabricated-by-e-beam-lithography
#9
Shankar B Rananavare, Moshood K Morakinyo
Nano-patterns fabricated with extreme ultraviolet (EUV) or electron-beam (E-beam) lithography exhibit unexpected variations in size. This variation has been attributed to statistical fluctuations in the number of photons/electrons arriving at a given nano-region arising from shot-noise (SN). The SN varies inversely to the square root of a number of photons/electrons. For a fixed dosage, the SN is larger in EUV and E-beam lithographies than for traditional (193 nm) optical lithography. Bottom-up and top-down patterning approaches are combined to minimize the effects of shot noise in nano-hole patterning...
February 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286420/hlbt-100-a-highly-potent-anti-cancer-flavanone-from-tillandsia-recurvata-l-l
#10
Henry I C Lowe, Ngeh J Toyang, Charah T Watson, Kenneth N Ayeah, Joseph Bryant
BACKGROUND: The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a top global priority. Our drug discovery approach is natural products based with a focus on plants. Tillandsia recurvata (L.) L. is one of the plants selected by our research team for further studies based on previous bioactivity findings on the anticancer activity of this plant...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28286309/pteryxin-a-promising-butyrylcholinesterase-inhibiting-coumarin-derivative-from-mutellina-purpurea
#11
Ilkay Erdogan Orhan, Fatma Sezer Senol, Suhaib Shekfeh, Krystyna Skalicka-Wozniak, Erden Banoglu
Pteryxin is a dihydropyranocoumarin derivative found in Apiaceae family. In this study, pteryxin, which was previously isolated from the fruits of Mutellina purpurea, was investigated for its inhibitory potential against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which are the key enzymes in the pathology of Alzheimer's disease (AD). The compound was tested in vitro using ELISA microplate reader at 100 μg/ml and found to cause 9.30 ± 1.86% and 91.62 ± 1.53% inhibition against AChE and BChE, respectively...
March 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28282483/polish-vocabulary-development-in-2-year-olds-comparisons-with-english-using-the-language-development-survey
#12
Leslie Rescorla, Holly Constants, Marta Bialecka-Pikul, Malgorzata Stepien-Nycz, Anna Ochal
Purpose: The objective of this study was to compare vocabulary size and composition in 2-year-olds learning Polish or English as measured by the Language Development Survey (LDS; Rescorla, 1989). Method: Participants were 199 Polish toddlers (M = 24.14 months, SD = 0.35) and 422 U.S. toddlers (M = 24.69 months, SD = 0.78). Results: Test-retest reliability was .92, internal consistency was .99, and concurrent validity was .55. Girls had higher vocabulary scores than boys...
March 10, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28279182/the-use-of-mesenchymal-stem-cells-for-cartilage-repair-and-regeneration-a-systematic-review
#13
REVIEW
Andy Goldberg, Katrina Mitchell, Julian Soans, Louise Kim, Razi Zaidi
BACKGROUND: The management of articular cartilage defects presents many clinical challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation techniques, such as microfracture, are the most frequently used method in clinical practice however the resulting mixed fibrocartilage tissue which is inferior to native hyaline cartilage. Other methods have shown promise but are far from perfect. There is an unmet need and growing interest in regenerative medicine and tissue engineering to improve the outcome for patients requiring cartilage repair...
March 9, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28276681/boosting-up-performance-of-inverted-photovoltaic-cells-from-bis-alkylthien-2-yl-dithieno-2-3-d-2-3-d-benzo-1-2-b-4-5-b-di-thiophene-based-copolymers-by-advantageous-vertical-phase-separation
#14
Pengzhi Guo, Guoping Luo, Qiang Su, Jianfeng Li, Peng Zhang, Junfeng Tong, Chunyan Yang, Yangjun Xia, Hongbin Wu
The photovoltaic cells (PVCs) from conjugated copolymers of PDTBDT-BT and PDTBDT-FBT with 5,10-bis(4,5-didecylthien-2-yl)dithieno[2,3-d:2',3'-d']benzo[1,2-b:4,5-b']dithiophene as electron donor moieties and benzothiadiazole and/or 5,6-difluorobenzothiadiazole as electron acceptor moieties are optimized by employing alcohol-soluble PFN (poly(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)) as cathode modification interlayer. The power conversion efficiencies (PCEs) of inverted PVCs (i-PVCs) from PDTBDT-BT and PDTBDT-FBT with devices configuration as ITO/PFN/active layer/MoO3/Ag are increased from 4...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28274752/a-novel-chronic-advanced-stage-abdominal-aortic-aneurysm-murine-model
#15
Guanyi Lu, Gang Su, John P Davis, Basil Schaheen, Emily Downs, R Jack Roy, Gorav Ailawadi, Gilbert R Upchurch
OBJECTIVE: The purpose of this study was to establish a reliable, chronic model of abdominal aortic aneurysm (AAA). METHODS: Wild-type 8-week-old C56BL/6 male mice (n = 120) were equally divided into three groups: (1) BAPN group: 0.2% 3-aminopropionitrile fumarate salt (BAPN) drinking water was provided to mice 2 days before surgery until the end of study. Sham aneurysm induction surgery was performed using 5 μL of heat deactivated elastase. (2) Elastase group: mice were given regular drinking water without BAPN...
March 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28268837/a-novel-algorithm-for-reducing-false-arrhythmia-alarms-in-intensive-care-units
#16
Chandan Srivastava, Sonal Sharma, Ali Jalali
Alarm fatigue in intensive care units (ICU) is one of the top healthcare issues in the US. False alarms in ICU will decrease the quality of care and staff response time over the alarms. Normally, false alarm will cause desensitization of the clinical staff which leads to warnings and misleading, if the triggered alarm is true. In this study, we have proposed a multi-model ensemble approach to reduce the false alarm rate in monitoring systems. We have used 750 patient records from PhysioNet database. At First arrhythmia based features from electrocardiogram (ECG), arterial blood pressure (ABP) and photoplethysmogram (PPG) features were extracted from the records...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266860/reduced-lateral-confinement-and-its-effect-on-stability-in-patterned-strong-polyelectrolyte-brushes
#17
Wei-Liang Chen, Matthias Menzel, Tsukasa Watanabe, Oswald Prucker, Jürgen Rühe, Christopher K Ober
The stability of strong polyelectrolyte brushes (PEBs) was studied in bulk and in patterned structures. Thick PEBs of poly([(2-methacryloyloxy)ethyl]trimethylammonium chloride) with thicknesses >100 nm were synthesized using single electron transfer living radical polymerization. Brush patterning was identified using deep-ultraviolet photolithography by means of either a top-down (TD) or bottom-up (BU) method, with features as small as 200 nm. The brushes were soaked in water under a range of pH or temperature conditions, and the hydrolysis was monitored through dry-state ellipsometry and atomic force microscopy measurements...
March 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28264485/effect%C3%A2-of%C3%A2-25-%C3%A2-sodium%C3%A2-reduction%C3%A2-on%C3%A2-sales%C3%A2-of%C3%A2-%C3%A2-a%C3%A2-top-selling%C3%A2-bread%C3%A2-in%C3%A2-remote%C3%A2-indigenous%C3%A2-australian%C3%A2-community%C3%A2-stores-%C3%A2-a%C3%A2-controlled%C3%A2-intervention%C3%A2-trial
#18
Emma McMahon, Jacqui Webster, Julie Brimblecombe
Reducing sodium in the food supply is key to achieving population salt targets, but maintaining sales is important to ensuring commercial viability and maximising clinical impact. We investigated whether 25% sodium reduction in a top-selling bread affected sales in 26 remote Indigenous community stores. After a 23-week baseline period, 11 control stores received the regular-salt bread (400 mg Na/100 g) and 15 intervention stores received the reduced-salt version (300 mg Na/100 g) for 12-weeks. Sales data were collected to examine difference between groups in change from baseline to follow-up (effect size) in sales (primary outcome) or sodium density, analysed using a mixed model...
February 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28264483/evolutionary%C3%A2-developments%C3%A2-in%C3%A2-interpreting%C3%A2-the%C3%A2-gluten-induced%C3%A2-mucosal%C3%A2-celiac%C3%A2-lesion-%C3%A2-an%C3%A2-archimedian%C3%A2-heuristic
#19
REVIEW
Michael N Marsh, Calvin J Heal
The evolving history of the small intestinal biopsy and its interpretation-and misinterpretations-are described in this paper. Certain interpretative errors in the technical approaches to histological assessment are highlighted-even though we may never be rid of them. For example, mucosal "flattening" does not reduce individual villi to their cores, as still seems to be widely believed. Neither is the mucosa undergoing an atrophic process-since it can recover structurally. Rather, the intestinal mucosa manifests a vast hypertrophic response resulting in the formation of large plateaus formed from partially reduced villi and their amalgamation with the now increased height and width of the inter-villous ridges: this is associated with considerable increases in crypt volumes...
February 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28263421/modelling-moose-forest-interactions-under-different-predation-scenarios-at-isle-royale-national-park-usa
#20
Nathan R De Jager, Jason J Rohweder, Brian R Miranda, Brian R Sturtevant, Timothy J Fox, Mark C Romanski
Loss of top predators may contribute to high ungulate population densities and chronic over-browsing of forest ecosystems. However, spatial and temporal variability in the strength of interactions between predators and ungulates occurs over scales that are much shorter than the scales over which forest communities change, making it difficult to characterize trophic cascades in forest ecosystems. We applied the LANDIS-II forest succession model and a recently developed ungulate browsing extension to model how the moose population could interact with the forest ecosystem of Isle Royale National Park, USA, under three different wolf predation scenarios...
March 6, 2017: Ecological Applications: a Publication of the Ecological Society of America
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