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Daphne C Duncombe
AIMS AND OBJECTIVES: The study aims were to examine perceived barriers and facilitators to implementing evidence-based practice among nurses working in psychiatric, geriatric, hospital and community settings in The Bahamas. BACKGROUND: It is evident from previous studies that a number of factors exist which either obstruct or promote the utilization of research evidence in nursing practice. Identifying these factors is vital to the successful uptake of evidence-based practice in nursing...
November 17, 2017: Journal of Clinical Nursing
Pål A Olsvik, Liv Søfteland
Decades after being banned in many countries, DDT and its metabolites are still considered major environmental hazards. The p,p'-DDE isomer, the DDT metabolite found in highest concentration in aquaculture feeds, is an endocrine disruptor with demonstrated ability to induce epigenetic effects. This study aimed at examining the impact of p,p'-DDE on Atlantic salmon. Primary hepatocytes were exposed to four concentrations of p,p'-DDE (0.1, 1, 10, 100 μm) for 48 hours, and endpoints included cytotoxicity, global DNA methylation, targeted transcription and metabolomics profiling (100 μm)...
November 17, 2017: Journal of Applied Toxicology: JAT
Maguy Saffouh El Hajj, Safae E Abu Yousef, Meena Ali Basri
Background Diabetes mellitus is recognized as a major public health issue and is one of the top ten causes of death in Qatar. Objective To describe the activities, and attitudes of Qatar pharmacists toward diabetes, to measure their diabetes knowledge and to assess their perceived barriers for diabetes care. Setting Community and ambulatory pharmacies in Qatar. Method Study objectives were addressed in a cross sectional survey of community and ambulatory pharmacists in Qatar. A phone call explaining the study was made to all community and ambulatory pharmacists in Qatar...
November 17, 2017: International Journal of Clinical Pharmacy
Fabian Wäldchen, Simon Becher, Patrick Esch, Mario Kompauer, Sven Heiles
The effect of double bond functionalisation for selective double bond localisation by ultraviolet photodissociation of phosphatidylcholines is investigated. Paternò-Büchi reactions in nanoESI emitter tips enable attachment of acetophenone to double bonds of unsaturated phosphatidylcholines after 100 s of 254 nm light irradiation with about 50-80% reaction yield. Functionalized phosphatidylcholines dissociate upon 266 nm irradiation yielding double bond selective fragment ions in contrast to results for ultraviolet photodissociation of unmodified lipids...
November 16, 2017: Analyst
Xiaoqiang Yang
The aim of the present study was to identify risk genes in myocardial infarction. Microarray data GSE34198, containing data from the peripheral blood of 49 myocardial infarction samples and 48 corresponding control samples, were downloaded from the Gene Expression Omnibus database to screen the differentially expressed genes (DEGs). The DEGs were used to construct a protein‑protein interaction (PPI) network of patient samples, from which the feature genes were identified using the neighboring score method...
November 14, 2017: Molecular Medicine Reports
Monali N Basutkar, Saumil Samant, Joseph Strzalka, Kevin G Yager, Gurpreet Singh, Alamgir Karim
Template-free directed self-assembly of ultrathin (~10's nm) lamellar block copolymer (l-BCP) films of high-interfacial area into vertically oriented nanodomains holds much technological relevance for fabrication of next-generation devices from nanoelectronics to nanomembranes due to domain interconnectivity and high interfacial area. We report for the first time, the formation of full thru-thickness vertically oriented lamellar domains in 100 nm thin polystyrene-block-poly(methyl methacrylate) (PS-b-PMMA) films on quartz substrate, achieved without any PMMA-block wetting layer formation, quartz surface modification (templating chemical, topographical) or system modifications (added surfactant, top-layer coat)...
November 14, 2017: Nano Letters
Kidan Lee, Hyomin Lee, Seung-Hyun Lee, Hyun-Mi Kim, Ki-Bum Kim, Sung Jae Kim
Solid-state nanopore is an ionic current-based biosensing platform, which would be a top candidate for next-generation DNA sequencing and a high-throughput drug-screening tool at single-molecular-scale resolution. There have been several approaches to enhance the sensitivity and reliability of biomolecule detection using the nanopores particularly in two aspects: signal-to-noise ratio (SNR) and translocation dwell time. In this study, an additional nano-well of 100-150 nm diameter and the aspect ratio of ∼5 called 'guide structure' was inserted in conventional silicon-substrate nanopore device to increase both SNR and dwell time...
November 13, 2017: Nanoscale
Micaela Ljunggren, Julia Persson, Jonatan Salzer
BACKGROUND: Dizziness is a common occurrence witnessed at emergency departments (EDs). This study aims to describe the epidemiology and management of dizzy patients with and without an acute vestibular syndrome (AVS) in the ED at Umeå University Hospital. METHODS: A total of n = 2,126 ED dizziness visits during 3 years were identified. Data were obtained through retrospective review of medical records. Cases were stratified based on presentation, including AVS and neurological deficits...
November 13, 2017: European Neurology
Duane Knudson
This study extended research on key citation metrics of winners of two career scholar awards in sports biomechanics. Google Scholar (GS) was searched using Harzing's Publish or Perish software for the 13 most recent winners of the ISBS Geoffrey Dyson Award and the ASB Jim Hay Memorial Award. Returned records were corrected for author, and publications excluded for all but peer-reviewed journal articles, proceedings articles, chapters and books in English. These recent award winners had published about 150 publications that had been cited typically 4,082 and 6,648 times over a 26- and 28-year period before receiving these career awards for sports biomechanics research...
November 13, 2017: Sports Biomechanics
Kazuaki Nagayama, Takuya Inoue, Yasuhiro Hamada, Takeo Matsumoto
Traction forces generated at cellular focal adhesions (FAs) play an essential role in regulating various cellular functions. These forces (1-100 nN) can be measured by observing the local displacement of a flexible substrate upon which cells have been plated. Approaches employing this method include using microfabricated arrays of poly(dimethylsiloxane) (PDMS) micropillars that bend by cellular traction forces. A tool capable of applying a force to FAs independently, by actively moving the micropillars, should become a powerful tool to delineate the cellular mechanotransduction mechanisms...
October 25, 2017: Journal of Biomechanics
Tomasz Hachaj, Marcin Piekarczyk, Marek R Ogiela
The aim of this paper is to propose and evaluate the novel method of template generation, matching, comparing and visualization applied to motion capture (kinematic) analysis. To evaluate our approach, we have used motion capture recordings (MoCap) of two highly-skilled black belt karate athletes consisting of 560 recordings of various karate techniques acquired with wearable sensors. We have evaluated the quality of generated templates; we have validated the matching algorithm that calculates similarities and differences between various MoCap data; and we have examined visualizations of important differences and similarities between MoCap data...
November 10, 2017: Sensors
Kuang-Rong Wei, Rong-Shou Zheng, Si-Wei Zhang, Zhi-Heng Liang, Zhu-Ming Li, Wan-Qing Chen
BACKGROUND: We estimated the incidence and mortality of nasopharyngeal carcinoma (NPC) in China in 2010 according to the data of 145 domestic population-based cancer registries in 2014, and no such reports since then. Hence, to further and better understand its epidemiology in China and to provide more precise scientific information for its control and prevention in China, we analyzed the NPC incidence and mortality of 255 domestic population-based cancer registries, and estimated the national rates in 2013 again...
November 9, 2017: Chinese Journal of Cancer
J Ryan Stewart, Michael H Heit, Kate V Meriwether, Deslyn T Hobson, Sean L Francis
OBJECTIVE: We sought to describe the readability of Web sites arising from the most common Google search terms related to pelvic organ prolapse, bladder control, and bowel control. METHODS: Google was queried to capture the top 100 search results for the keywords in each disease group. For the top 20 results of each keyword, we analyzed the text for readability using 4 readability formulas: Dale-Chall, Gunning-Fog, Simple Measure of Gobbledygook (SMOG), and Flesch-Kincaid Grade Level...
November 7, 2017: Female Pelvic Medicine & Reconstructive Surgery
Diana Vetter, Hendrik Ruhwinkel, Dimitri A Raptis, Marco Bueter
OBJECTIVE: The aim of this study was to assess the quality of patient information on bariatric surgery in the internet using the modified Ensuring Quality Information for Patients (EQIP) tool. METHODS: Systematic review of information on bariatric surgery in the internet by entering common search terms into five search engines. The top 100 websites of every search term and search engine were assessed using the validated EQIP tool (maximum score, 36), which entails points for content, structure, and identification data of a given website...
November 6, 2017: Obesity Surgery
Hao Yu, He Shang, Jixin Cao, Zhan Chen
Numerous studies have demonstrated the negative effects of elevated O3 on leaf photosynthesis. Within trees, a portion of respired CO2 is assimilated by woody tissue photosynthesis, but its response to elevated O3 remains unclear. Saplings of two evergreen tree species, EuCahetus dunnii Maiden (E. dunnii) and Osmanthus fragrans (Thunb.) Lour. (O. fragrans), were exposed to non-filtered air (NF), 100 nmol mol(-1) O3 air (E1) and 150 nmol mol(-1) O3 air (E2) in open-top chambers from May 5 to September 5, 2016 (8 h a day; 7 days a week) in subtropical China...
November 6, 2017: Environmental Science and Pollution Research International
Mark Müller, Ivo de Sena Oliveira, Sebastian Allner, Simone Ferstl, Pidassa Bidola, Korbinian Mechlem, Andreas Fehringer, Lorenz Hehn, Martin Dierolf, Klaus Achterhold, Bernhard Gleich, Jörg U Hammel, Henry Jahn, Georg Mayer, Franz Pfeiffer
X-ray computed tomography (CT) is a powerful noninvasive technique for investigating the inner structure of objects and organisms. However, the resolution of laboratory CT systems is typically limited to the micrometer range. In this paper, we present a table-top nanoCT system in conjunction with standard processing tools that is able to routinely reach resolutions down to 100 nm without using X-ray optics. We demonstrate its potential for biological investigations by imaging a walking appendage of Euperipatoides rowelli, a representative of Onychophora-an invertebrate group pivotal for understanding animal evolution...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
Qi Zhong, Aiping Xiong, Kim-Phuong L Vu, Robert W Proctor
Conde et al. (Exp Brain Res 233:3313-3321, 2015) found that the Simon effect for vertically arrayed stimuli and responses was reduced after 100 prior practice trials with an incompatible mapping of the stimulus locations and responses. This finding was contrary to Vu's (Mem Cognit 35:1463-1471, 2007) finding of no transfer effect with 72 trials of prior practice. Conde et al. proposed that the different results were due to their responses being coded as top and bottom in the frontal plane, whereas Vu's were coded as far and near in the transverse plane...
November 4, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Giovanni M Di Liberto, Edmund C Lalor, Rebecca E Millman
Speech perception may be underpinned by a hierarchical cortical system, which attempts to match "external" incoming sensory inputs with "internal" top-down predictions. Prior knowledge modulates internal predictions of an upcoming stimulus and exerts its effects in temporal and inferior frontal cortex. Here, we used source-space magnetoencephalography (MEG) to study the spatiotemporal dynamics underpinning the integration of prior knowledge in the speech processing network. Prior knowledge was manipulated to i) increase the perceived intelligibility of speech sentences, and ii) dissociate the perceptual effects of changes in speech intelligibility from acoustical differences in speech stimuli...
November 2, 2017: NeuroImage
Jinying Chen, Abhyuday N Jagannatha, Samah J Fodeh, Hong Yu
BACKGROUND: Medical terms are a major obstacle for patients to comprehend their electronic health record (EHR) notes. Clinical natural language processing (NLP) systems that link EHR terms to lay terms or definitions allow patients to easily access helpful information when reading through their EHR notes, and have shown to improve patient EHR comprehension. However, high-quality lay language resources for EHR terms are very limited in the public domain. Because expanding and curating such a resource is a costly process, it is beneficial and even necessary to identify terms important for patient EHR comprehension first...
October 31, 2017: JMIR Medical Informatics
Nobuhiro Sakamoto, Shuji Takiguchi, Hirokazu Komatsu, Toru Okuyama, Tomohiro Nakaguchi, Yosuke Kubota, Yoshinori Ito, Koji Sugano, Makoto Wada, Tatsuo Akechi
Background: Although currently many advanced colorectal cancer patients continuously receive chemotherapy, there are very few findings with regard to the supportive care needs of such patients. Methods: The purposes of this study were to investigate the patients' perceived needs and the association with psychological distress and/or quality of life, and to clarify the characteristics of patients with a high degree of unmet needs. Ambulatory colorectal cancer patients who were receiving chemotherapy were asked to complete the Short-Form Supportive Care Needs Survey questionnaire, which covers five domains of need (health system and information, psychological, physical, care and support, and sexuality needs), the Hospital Anxiety and Depression Scale and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire...
October 25, 2017: Japanese Journal of Clinical Oncology
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