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https://www.readbyqxmd.com/read/27914366/rapid-and-low-cost-biosensor-for-the-detection-of-staphylococcus-aureus
#1
Ghadeer A R Y Suaifan, Sahar Alhogail, Mohammed Zourob
Staphylococcus aureus (S. aureus) is one of the most common etiological agents in hospital-acquired infections and food-borne illness. S. aureus toxins and virulence proteases often circulate in host blood vessels leading to life-threatening diseases. Standard identification approaches include bacterial culturing method, which takes several days. Other nucleic acid-based methods were expensive and required trained personnel. To surmount these limitations, a paper-based biosensor was developed. The sensing mechanism was based on the proteolytic activity of S...
November 21, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27913594/highlights-in-bioethics-through-40%C3%A2-years-a-quantitative-analysis-of-top-cited-journal-articles
#2
Pingyue Jin, Mark Hakkarinen
BACKGROUND: The field of bioethics is constantly evolving. To investigate trends in the field of bioethics, we conducted a quantitative analysis of the top-cited articles in bioethical journals over the past 40 years. METHODS: Retrospective quantitative study of the 20 most cited bioethics articles published each year from 1975 to 2014 were conducted. Article samples were selected from a list of the most relevant 100 journals in the field of bioethics. RESULTS: In total, 800 top-cited articles between 1975 and 2014 in the domain of bioethics were retrieved and analysed...
December 2, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27909898/two-dimensional-polyaniline-nanostructure-to-the-development-of-microfluidic-integrated-flexible-biosensors-for-biomarker-detection
#3
Pei Liu, Yisi Zhu, Seung Hee Lee, Minhee Yun
In this work, we report a flexible field-effect-transistor (FET) biosensor design based on two-dimensional (2-D) polyaniline (PANI) nanostructure. The flexible biosensor devices were fabricated through a facile and inexpensive method that combines top-down and bottom-up processes. The chemically synthesized PANI nanostructure showed excellent p-type semiconductor properties as well as good compatibility with flexible design. With the 2-D PANI nanostructure being as thin as 80 nm and its extremely large surface-area-to-volume (SA/V) ratio due to the intrinsic properties of PANI chemical synthesis, the developed flexible biosensor exhibited outstanding sensing performance in detecting B-type natriuretic peptide (BNP) biomarkers, and was able to achieve high specificity (averagely 112 folds) with the limit of detection as low as 100 pg/mL...
December 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27908095/the-effect-of-frequency-cueing-on-the-perceptual-segregation-of-simultaneous-tones-bottom-up-and-top-down-contributions
#4
Yi Shen
Listeners were presented with two simultaneous tones of different frequencies (more than one octave apart) and asked to identify the tone that was amplitude-modulated while a tonal precursor was presented to cue the frequency of the lower frequency tone. Performance thresholds were estimated based on the duration of the tone-pair. In Exp. I the duration of the precursor varied from 100 to 400 ms and the inter-stimulus interval (ISI) between the precursor and the tone-pair varied from 0 to 1 s. The presence of the precursor facilitated segregation...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27905975/health-profile-of-centenarians-in-portugal-a-census-based-approach
#5
Oscar Ribeiro, Laetitia Teixeira, Lia Araújo, Constança Paúl
BACKGROUND: The number of centenarians is rapidly increasing in Europe. In Portugal, it has almost tripled over the last 10 years and constitutes one of the fastest-growing segments of the population. This paper aims to describe the health and sociodemographic characteristics of Portuguese centenarians as given in the 2011 census and to identify sex differences. METHODS: All persons living in Portugal mainland and Madeira and Azores islands aged 100 years old at the time of the 2011 census (N = 1,526) were considered...
April 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27900743/-the-relationship-between-coping-behaviors-and-symptom-distress-in-elderly-patients-with-cancer-undergoing-initial-chemotherapy
#6
Shih-Ping Wu, Ya-Chuan Hsu
BACKGROUND: Elderly cancer patients undergoing initial chemotherapy often suffer discomfort from medication-related symptom distress. This discomfort may affect treatment responses and outcomes negatively. PURPOSE: This correlational, cross-sectional design study used a purposive sample of 100 patients who were both over 60 years of age and currently undergoing initial chemotherapy. The participants completed a structured questionnaire that was administered at a medical center in southern Taiwan...
December 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27899147/top-classic-citations-in-pancreatic-cancer-research
#7
Qiang Li, Yuan Jiang
BACKGROUND: The number of times that articles are cited by is widely used to evaluate the impact of an article or an individual author has on its scientific community. This bibliometric analysis aimed to explore the top classic citations in pancreatic cancer (PC) research. METHODS: A computerized literature search was conducted using the database, the Science Citation Index Expanded. The top 100 highly cited articles were included and further analyzed. RESULTS: The most cited article had 3,032 citations, with a mean of 626 citations per paper...
November 29, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27898882/genome-scan-for-postmortem-carcass-traits-in-nellore-cattle
#8
G A Fernandes Júnior, R B Costa, G M F de Camargo, R Carvalheiro, G J M Rosa, F Baldi, D A Garcia, D G M Gordo, R Espigolan, L Takada, A F B Magalhães, T Bresolin, F L B Feitosa, L A L Chardulo, H N de Oliveira, L G de Albuquerque
Carcass traits measured after slaughter are economically relevant traits in beef cattle. In general, the slaughter house payment system is based on HCW. Ribeye area (REA) is associated with the amount of the meat in the carcass, and a minimum of backfat thickness (BFT) is necessary to protect the carcass during cooling. The aim of this study was to identify potential genomic regions harboring candidate genes affecting those traits in Nellore cattle. The data set used in the present study consisted of 1,756 Nellore males with phenotype records...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27881267/cost-utility-analysis-of-human-papillomavirus-vaccination-and-cervical-screening-on-cervical-cancer-patient-in-indonesia
#9
Didik Setiawan, Franklin Christiaan Dolk, Auliya A Suwantika, Tjalke Arend Westra, Jan C WIlschut, Maarten Jacobus Postma
BACKGROUND: Although cervical cancer is a preventable disease, the clinical and economic burdens of cervical cancer are still substantial issues in Indonesia. OBJECTIVES: The main purpose of this study was to model the costs, clinical benefits, and cost-utility of both visual inspection with acetic acid (VIA) screening alone and human papillomavirus (HPV) vaccination in addition to VIA screening in Indonesia. METHODS: We developed a population-based Markov model, consisting of three health states (susceptible, cervical cancer, and death), to assess future costs, health effects, and the cost-utility of cervical cancer prevention strategies in Indonesia...
May 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27878901/radioactive-cesium-and-potassium-in-cattle-living-in-the-zone-in-preparation-for-the-lifting-of-the-evacuation-order-of-the-fukushima-nuclear-accident
#10
Itaru Sato, Jun Sasaki, Hiroshi Satoh, Takahisa Murata, Kumiko Otani, Keiji Okada
To contribute to the reconstruction of livestock industry in Fukushima, radioactive cesium ((134) Cs, (137) Cs) and potassium ((4) °K) were measured in various tissues of beef cattle living in an area where the evacuation order will be lifted in the near future. Radioactive cesium concentration was less than 100 Bq/kg in most of the samples. Skeletal muscles and kidney had the highest concentrations of radioactive cesium, whereas the liver was lowest among samples, excepting blood. Radioactive cesium concentration in the sirloin, tenderloin and top round was significantly higher than that in the neck muscle...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27878816/diel-shifts-in-the-structure-and-function-of-nearshore-estuarine-fish-communities
#11
D E Yeoh, F J Valesini, C S Hallett, D A Abdo, J Williams
Day-night shifts in the nearshore fish fauna of a temperate microtidal estuary were assessed using a holistic suite of structural and functional community attributes. Mean fish species richness and diversity (taxonomic distinctness) were higher at night across all regions of the estuary and seasons, concurring with the findings of numerous comparable studies reviewed worldwide, while the diel period in which mean abundance was higher varied among seasons. Likewise, species and functional guild compositions (the latter based on feeding modes and habitat use) both differed significantly between day and night, with the extent of the diel shift again varying seasonally...
November 23, 2016: Journal of Fish Biology
https://www.readbyqxmd.com/read/27870662/introducing-copayments-in-the-emergency-department-would-deter-appropriate-visits-in-the-netherlands
#12
Nicole Kraaijvanger, Douwe Rijpsma, Henk van Leeuwen, Michael Edwards
OBJECTIVE: To determine what the effects of introduction of copayments for self-referred emergency department (ED) visits would be in the Netherlands and at what amount patients would turn to a GP before visiting an ED. METHODS: This questionnaire study was carried out in the ED of the Rijnstate Hospital, a community teaching hospital in the Netherlands. In the Netherlands, a deductible excess system is in use and this study investigated the effects of a copayment for self-referred patients (SRPs) on top of the deductible excess...
November 18, 2016: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/27866473/top-100-cited-articles-in-cardiovascular-magnetic-resonance-a-bibliometric-analysis
#13
REVIEW
Muhammad Shahzeb Khan, Waqas Ullah, Irbaz Bin Riaz, Nizar Bhulani, Warren J Manning, Srini Tridandapani, Faisal Khosa
BACKGROUND: With limited health care resources, bibliometric studies can help guide researchers and research funding agencies towards areas where reallocation or increase in research activity is warranted. Bibliometric analyses have been published in many specialties and sub-specialties but our literature search did not reveal a bibliometric analysis on Cardiovascular Magnetic Resonance (CMR). The main objective of the study was to identify the trends of the top 100 cited articles on CMR research...
November 21, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27866001/generating-disease-pertinent-treatment-vocabularies-from-medline-citations
#14
Liqin Wang, Guilherme Del Fiol, Bruce E Bray, Peter J Haug
OBJECTIVE: Healthcare communities have identified a significant need for disease-specific information. Disease-specific ontologies are useful in assisting the retrieval of disease-relevant information from various sources. However, building these ontologies is labor intensive. Our goal is to develop a system for an automated generation of disease-pertinent concepts from a popular knowledge resource for the building of disease-specific ontologies. METHODS: A pipeline system was developed with an initial focus of generating disease-specific treatment vocabularies...
November 16, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27861356/a-childhood-acute-lymphoblastic-leukemia-genome-wide-association-study-identifies-novel-sex-specific-risk-variants
#15
Sandeep K Singh, Philip J Lupo, Michael E Scheurer, Anshul Saxena, Amy E Kennedy, Boubakari Ibrahimou, Manuel Alejandro Barbieri, Ken I Mills, Jacob L McCauley, Mehmet Fatih Okcu, Mehmet Tevfik Dorak
Childhood acute lymphoblastic leukemia (ALL) occurs more frequently in males. Reasons behind sex differences in childhood ALL risk are unknown. In the present genome-wide association study (GWAS), we explored the genetic basis of sex differences by comparing genotype frequencies between male and female cases in a case-only study to assess effect-modification by sex.The case-only design included 236 incident cases of childhood ALL consecutively recruited at the Texas Children's Cancer Center in Houston, Texas from 2007 to 2012...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27852983/ultracold-neutral-plasmas
#16
M Lyon, S L Rolston
By photoionizing samples of laser-cooled atoms with laser light tuned just above the ionization limit, plasmas can be created with electron and ion temperatures below 10 K. These ultracold neutral plasmas have extended the temperature bounds of plasma physics by two orders of magnitude. Table-top experiments, using many of the tools from atomic physics, allow for the study of plasma phenomena in this new regime with independent control over the density and temperature of the plasma through the excitation process...
November 17, 2016: Reports on Progress in Physics
https://www.readbyqxmd.com/read/27851665/measurement-properties-of-the-brazilian-portuguese-version-of-the-lumbar-spine-instability-questionnaire
#17
Amanda Costa Araujo, Lucíola da Cunha Menezes Costa, Crystian Bittencourt Oliveira, Priscila Kalil Morelhão, Rúben Faria Negrão Filho, Rafael Zambelli Pinto, Leonardo Oliveira Pena Costa
STUDY DESIGN: Cross-cultural adaptation and analysis of measurement properties. OBJECTIVE: To translate and cross-culturally adapt the Lumbar Spine Instability Questionnaire (LSIQ) into Brazilian-Portuguese and to test its measurement properties in Brazilian patients with low back pain. SUMMARY OF BACKGROUND DATA: The selection of subgroup of patients that respond better to specific interventions is the top research priority in the field of back pain...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27842874/characterisation-of-meticillin-resistant-staphylococcus-aureus-st97-and-st5-isolated-from-pigs-in-japan
#18
Tomomi Sato, Masaru Usui, Takumi Motoya, Terumi Sugiyama, Yutaka Tamura
The objective of this study was to determine the frequency and clonal types of meticillin-resistant Staphylococcus aureus (MRSA) among slaughter pigs in a top pig-producing area in Japan. In total, 100 nasal swabs were collected from slaughterhouse pigs originating from 21 different farms. MRSA isolates were analysed by staphylococcal cassette chromosome mec (SCCmec) typing, spa typing and multilocus sequence typing (MLST) and were examined for susceptibility to nine antimicrobial agents (ampicillin, oxacillin, gentamicin, kanamycin, erythromycin, clindamycin, vancomycin, ciprofloxacin and tetracycline)...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27834660/private-and-efficient-query-processing-on-outsourced-genomic-databases
#19
Reza Ghasemi, Md Momin Al Aziz, Noman Mohammed, Massoud Hadian Dehkordi, Xiaoqian Jiang
Applications of genomic studies are spreading rapidly in many domains of science and technology such as healthcare, biomedical research, direct-to-consumer services, and legal and forensic. However, there are a number of obstacles that make it hard to access and process a big genomic database for these applications. First, sequencing genomic sequence is a timeconsuming and expensive process. Second, it requires large-scale computation and storage systems to processes genomic sequences. Third, genomic databases are often owned by different organizations and thus not available for public usage...
November 4, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27828039/implementation-of-a-svwp-based-laser-beam-shaping-technique-for-generation-of-100-mj-level-picosecond-pulses
#20
J Adamonis, A Aleknavičius, K Michailovas, S Balickas, V Petrauskienė, T Gertus, A Michailovas
We present implementation of the energy-efficient and flexible laser beam shaping technique in a high-power and high-energy laser amplifier system. The beam shaping is based on a spatially variable wave plate (SVWP) fabricated by femtosecond laser nanostructuring of glass. We reshaped the initially Gaussian beam into a super-Gaussian (SG) of the 12th order with efficiency of about 50%. The 12th order of the SG beam provided the best compromise between large fill factor, low diffraction on the edges of the active media, and moderate intensity distribution modification during free-space propagation...
October 1, 2016: Applied Optics
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