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https://www.readbyqxmd.com/read/28723967/epitope-determination-of-immunogenic-proteins-of-neisseria-gonorrhoeae
#1
Daniel O Connor, Lena Danckert, Sebastian Hoppe, Frank F Bier, Markus von Nickisch-Rosenegk
Neisseria gonorrhoeae is the causative organism of gonorrhoea, a sexually transmitted disease that globally accounts for an estimated 80 to 100 million new infections per year. Increasing resistances to all common antibiotics used for N. gonorrhoeae treatment pose the risk of an untreatable disease. Further knowledge of ways of infection and host immune response are needed to understand the pathogen-host interaction and to discover new treatment alternatives against this disease. Therefore, detailed information about immunogenic proteins and their properties like epitope sites could advance further research in this area...
2017: PloS One
https://www.readbyqxmd.com/read/28723120/graphene-oxide-nanoprisms-for-sensitive-detection-of-environmentally-important-aromatic-compounds-with-sers
#2
Peter V Shanta, Quan Cheng
Recent advances in graphene-based sensors have shown that heavily oxidized (GO) and reduced graphene oxide (rGO) are attractive materials for environmental sensing due to their unique chemical and physical properties. We describe here the fabrication of nanostructured GO assemblies with Ag nanoprisms for improved detection with surface enhanced Raman scattering (SERS). Specifically, 100-μm-sized, periodic-nanoprism-array domains were fabricated on top of the GO layers by GO-assisted lithography (GOAL). The atomically thin GO underlayers are shown to attract cyclic aromatic molecules to the surface, likely via π-π stacking interactions...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723074/paper-based-bimodal-sensor-for-electronic-skin-applications
#3
Minhyun Jung, Kyungkwan Kim, Bumjin Kim, Haena Cheong, Kwanwoo Shin, Oh-Sun Kwon, Jong-Jin Park, Sanghun Jeon
We present the development of a flexible bimodal sensor using a paper platform and ink-jet printing method, which are suited for low-cost fabrication processes and realization of flexible devices. In this study, we employed a vertically stacked bimodal device architecture in which a temperature sensor is stacked on top of a pressure sensor and operated on different principles, allowing the minimization of interference effects. For the temperature sensor placed in the top layer, we used the thermoelectric effect and formed a closed-loop thermocouple composed of two different printable inks: conductive PEDOT:PSS and silver nanoparticles on a flexible paper platform, and obtained temperature-sensing capability over a wide range (150 ℃)...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28721039/top-down-nanofabrication-of-silicon-nanoribbon-field-effect-transistor-si-nr-fet-for-carcinoembryonic-antigen-detection
#4
Zengtao Bao, Jialin Sun, Xiaoqian Zhao, Zengyao Li, Songkui Cui, Qingyang Meng, Ye Zhang, Tong Wang, Yanfeng Jiang
Sensitive and quantitative detection of tumor markers is highly required in the clinic for cancer diagnosis and consequent treatment. A field-effect transistor-based (FET-based) nanobiosensor emerges with characteristics of being label-free, real-time, having high sensitivity, and providing direct electrical readout for detection of biomarkers. In this paper, a top-down approach is proposed and implemented to fulfill a novel silicon nano-ribbon FET, which acts as biomarker sensor for future clinical application...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28718982/design-and-solution-phase-synthesis-of-membrane-targeting-lipopeptides-with-selective-antibacterial-activity
#5
Mohini Mohan Konai, Utsarga Adhikary, Jayanta Haldar
Designing selective antibacterial molecules remains an unmet goal in the field of membrane targeting agents. To this aim, herein we report the rational design and synthesis of a new class of lipopeptides which possess highly selective bacterial killing over mammalian cells. The selective interaction with bacterial over mammalian membranes was established through various spectroscopic as well as microscopic experiments including biophysical studies with the model membranes. A detailed antibacterial structure-activity relationship was delineated after preparing a series of molecules consisting of the peptide moieties with varied sequence of amino acids such as D-phenylalanine, D-leucine and D-lysine...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28718747/the-role-of-temporal-disparity-on-audiovisual-integration-in-low-vision-individuals
#6
Stefano Targher, Rocco Micciolo, Valeria Occelli, Massimiliano Zampini
Recent findings have shown that sounds improve visual detection in low vision individuals when the audiovisual stimuli pairs of stimuli are presented simultaneously and from the same spatial position. The present study purports to investigate the temporal aspects of the audiovisual enhancement effect previously reported. Low vision participants were asked to detect the presence of a visual stimulus (yes/no task) presented either alone or together with an auditory stimulus at different stimulus onset asynchronies (SOAs)...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28718454/high-aspect-ratio-sharp-nanotip-for-nanocantilever-integration-at-cmos-compatible-temperature
#7
P Wang, A Michael, C Y Kwok
In this paper, we demonstrate a novel low temperature nanofabrication approach that enables the formation of ultra-sharp high aspect ratio (HAR) and high density nanotip structures and their integration onto nanoscale cantilever beams. The nanotip structure consists of a nanoscale thermally evaporated Cr Spindt tip on top of an amorphous silicon rod. An apex radius of the tip, as small as 2.5 nm, has been achieved, and is significantly smaller than any other Spindt tips reported so far. 100 nm wide tips with aspect ratio of more than 50 and tip density of more than 5 × 10(9) tips cm(-2) have been fabricated...
August 11, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28713339/concurrent-methane-production-and-oxidation-in-surface-sediment-from-aarhus-bay-denmark
#8
Ke-Qing Xiao, Felix Beulig, Kasper U Kjeldsen, Bo B Jørgensen, Nils Risgaard-Petersen
Marine surface sediments, which are replete with sulfate, are typically considered to be devoid of endogenous methanogenesis. Yet, methanogenic archaea are present in those sediments, suggesting a potential for methanogenesis. We used an isotope dilution method based on sediment bag incubation and spiking with (13)C-CH4 to quantify CH4 turnover rates in sediment from Aarhus Bay, Denmark. In two independent experiments, highest CH4 production and oxidation rates (>200 pmol cm(-3) d(-1)) were found in the top 0-2 cm, below which rates dropped below 100 pmol cm(-3) d(-1) in all other segments down to 16 cm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28708096/characterization-of-non-nutritive-sweetener-intake-in-rural-southwest-virginian-adults-living-in-a-health-disparate-region
#9
Valisa E Hedrick, Erin M Passaro, Brenda M Davy, Wen You, Jamie M Zoellner
Few data assessing non-nutritive sweetener (NNS) intake are available, especially within rural, health-disparate populations, where obesity and related co-morbidities are prevalent. The objective of this study is to characterize NNS intake for this population and examine the variance in demographics, cardio-metabolic outcomes, and dietary intake between NNS consumers and non-consumers. A cross-sectional sample (n = 301) of Virginian adults from a randomized controlled trial (data collected from 2012 to 2014) targeting sugar-sweetened beverage (SSB) intake completed three 24-h dietary recalls, and demographics and cardio-metabolic measures were assessed...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28705525/the-top-100-most-cited-articles-in-stroke-imaging-a-bibliometric-analysis
#10
REVIEW
Mohammed F Mohammed, Olivia Marais, Adnan Qureshi, Nizar Bhulani, David Ferguson, Hossain Abu-Alola, Savvas Nicolaou, Faisal Khosa
PURPOSE: The goal of our study was to compile a list of the top 100 most-cited articles in stroke imaging literature across all peer-reviewed scientific journals. These articles were then analyzed to identify current trends in stroke imaging research and determine the characteristics of highly-cited articles. MATERIALS AND METHODS: A database of the top 100 most-cited articles was created using Scopus and Web of Science. Articles were reviewed for applicability by 2 fellowship-trained radiologists with over 10 years of combined experience in neuroimaging...
June 6, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28694704/health-care-provider-experience-with-canagliflozin-in-real-world-clinical-practice-favorability-treatment-patterns-and-patient-outcomes
#11
Susan C Bolge, Natalia M Flores, Shu Huang, Jennifer Cai
PURPOSE: This study describes how health care providers approach canagliflozin for the treatment of patients with type 2 diabetes mellitus (T2DM) in the real world. PATIENTS AND METHODS: An Internet-based questionnaire was completed by 101 endocrinologists, 101 primary care physicians, and 100 nurse practitioners/physician assistants (NP/PAs). Health care providers were required to have experience prescribing or managing patients using canagliflozin to be included in the study...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28693758/the-u-s-online-news-coverage-of-mammography-based-on-a-google-news-search
#12
REVIEW
Leng Leng Young Lin, Andrew B Rosenkrantz
RATIONALE AND OBJECTIVES: To characterize online news coverage relating to mammography, including articles' stance toward screening mammography. MATERIALS AND METHODS: Google News was used to search U.S. news sites over a 9-year period (2006-2015) based on the search terms "mammography" and "mammogram." The top 100 search results were recorded. Identified articles were manually reviewed. RESULTS: The top 100 news articles were from the following sources: local news outlet (50%), national news outlet (24%), nonimaging medical source (13%), entertainment or culture news outlet (6%), business news outlet (4%), peer-reviewed journal (1%), and radiology news outlet (1%)...
July 7, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28693589/the-recurrent-campylobacteriosis-epidemic-over-christmas-and-new-year-in-european-countries-2006-2014
#13
Philipp Justus Bless, Claudia Schmutz, Daniel Mäusezahl
OBJECTIVE: Campylobacteriosis is the most frequently reported foodborne disease in Europe with a notification rate of 71 per 100,000 population in the European Union in 2014. Surveillance data show a clear seasonality whereby case numbers peak during summer months in entire Europe and at the turn of the year, especially in Germany and Switzerland. A detailed description of European surveillance data by country at the turn of the year was missing so far. The objectives of the presented work were to describe national surveillance data of The European Surveillance System for 14 countries during winter times and to generate hypotheses for the observed seasonality of campylobacteriosis cases...
July 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28691714/dehydration-of-subducting-slow-spread-oceanic-lithosphere-in-the-lesser-antilles
#14
Michele Paulatto, Mireille Laigle, Audrey Galve, Philippe Charvis, Martine Sapin, Gaye Bayrakci, Mikael Evain, Heidrun Kopp
Subducting slabs carry water into the mantle and are a major gateway in the global geochemical water cycle. Fluid transport and release can be constrained with seismological data. Here we use joint active-source/local-earthquake seismic tomography to derive unprecedented constraints on multi-stage fluid release from subducting slow-spread oceanic lithosphere. We image the low P-wave velocity crustal layer on the slab top and show that it disappears beneath 60-100 km depth, marking the depth of dehydration metamorphism and eclogitization...
July 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28691252/peptide-backbone-circularization-enhances-antifreeze-protein-thermostability
#15
Corey A Stevens, Joanna Semrau, Dragos Chiriac, Morgan Litschko, Robert L Campbell, David N Langelaan, Steven P Smith, Peter L Davies, John S Allingham
Antifreeze proteins (AFPs) are a class of ice-binding proteins that promote survival of a variety of cold-adapted organisms by decreasing the freezing temperature of bodily fluids. A growing number of biomedical, agricultural and commercial products, such as organs, foods, and industrial fluids, have benefited from the ability of AFPs to control ice crystal growth and prevent ice recrystallization at subzero temperatures. One limitation of AFP use in these latter contexts is their tendency to denature and irreversibly lose activity at the elevated temperatures of certain industrial processing or large-scale AFP production...
July 10, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28689518/colon-cancer-screening-is-it-time-yet
#16
EDITORIAL
Hadi Bhurgri, Sami Samiullah
The month of March is dedicated to Colon Cancer Awareness. Worldwide, colorectal cancer (CRC) incidence has been on the rise. It is currently the third most common cancer in men (746,000 cases, 10.0% of the total) and the second in women (614,000 cases, 9.2% of the total).1 Arecent meta-analysis reported a 61% risk reduction in CRC incidence with colonoscopy.2 Unlike screening programs for breast and prostate cancers, not only has CRC screening reduced mortality from colon cancer and detected early CRC, it has also decreased the incidence of CRC through detection and removal of pre-cancerous lesions...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28677592/crystallographic-structure-and-energetics-of-the-rh-100-3%C3%A3-1-2o-phase
#17
Tilman Kißlinger, Pascal Ferstl, M Alexander Schneider, Lutz Hammer
In this study we investigate the crystallographic structure of the Rh(100)-(3×1)-2O phase by quantitative low energy electron diffraction (LEED) and scanning tunnelling microscopy (STM) as well as the energetics of the system applying density functional theory calculations (DFT). The (3×1) structure forms upon exposing the clean Rh(100) surface to 1200 L of oxygen at 520 K. A full-dynamical LEED intensity analysis (Pendry R-factor R = 0.095) reveals an oxygen-induced shifted row-reconstruction of the rhodium top layer where every third Rh-row is displaced by half a surface lattice parameter along the [011]-direction...
July 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28674666/who-are-the-important-predators-of-sea-turtle-nests-at-wreck-rock-beach
#18
Juan Lei, David T Booth
Excessive sea turtle nest predation is a problem for conservation management of sea turtle populations. This study assessed predation on nests of the endangered loggerhead sea turtle (Caretta caretta) at Wreck Rock beach adjacent to Deepwater National Park in Southeast Queensland, Australia after a control program for feral foxes was instigated. The presence of predators on the nesting dune was evaluated by tracking plots (2 × 1 m) every 100 m along the dune front. There were 21 (2014-2015) and 41 (2015-2016) plots established along the dune, and these were monitored for predator tracks daily over three consecutive months in both nesting seasons...
2017: PeerJ
https://www.readbyqxmd.com/read/28670374/combination-of-circulating-mir-19b-3p-mir-122-5p-and-mir-486-5p-expressions-correlates-with-risk-and-disease-severity-of-knee-osteoarthritis
#19
Ruina Kong, Jie Gao, Yanhui Si, Dongbao Zhao
The aim of this study was to investigate the association of circulating miRNAs profile with the risk of knee osteoarthritis (OA), and evaluate their correlation with clinical characteristics. This study was divided into two parts: exploration stage and validation stage. In exploration stage, 8 knee OA patients and 8 age and gender highly matched health controls (HCs) were recruited, and plasma sample were collected for microarray examination. Differentially expressed miRNAs and enrichment analysis were subsequently performed...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28665450/predicting-mirna-targets-for-head-and-neck-squamous-cell-carcinoma-using-an-ensemble-method
#20
Hong Gao, Hui Jin, Guijun Li
BACKGROUND: This study aimed to uncover potential microRNA (miRNA) targets in head and neck squamous cell carcinoma (HNSCC) using an ensemble method which combined 3 different methods: Pearson's correlation coefficient (PCC), Lasso and a causal inference method (i.e., intervention calculus when the directed acyclic graph (DAG) is absent [IDA]), based on Borda count election. METHODS: The Borda count election method was used to integrate the top 100 predicted targets of each miRNA generated by individual methods...
June 19, 2017: International Journal of Biological Markers
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