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https://www.readbyqxmd.com/read/28535189/predicting-accurate-contacts-in-thousands-of-pfam-domain-families-using-pconsc3
#1
Mirco Michel, Marcin J Skwark, David Menéndez Hurtado, Magnus Ekeberg, Arne Elofsson
Motivation: A fewyears ago it was shown that by using amaximumentropy approach to describe couplings between columns in a multiple sequence alignment it is possible to significantly increase the accuracy of residue contact predictions. For very large protein families with more than 1000 effective sequences the accuracy is sufficient to produce accurate models of proteins as well as complexes. Today, for about half of all Pfam domain families no structure is known, but unfortunately most of these families have at most a few hundred members, i...
May 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28531344/citation-classics-in-neuro-oncology-assessment-of-historical-trends-and-scientific-progress
#2
Laureen D Hachem, Alireza Mansouri, Kyle Juraschka, Shervin Taslimi, Farhad Pirouzmand, Gelareh Zadeh
Background.: Citation classics represent the highest cited works in a field and are often regarded as the most influential literature. Analyzing thematic trends in citation classics across eras enables recognition of important historical advances within a field. We present the first analysis of the citation classics in neuro-oncology. Methods.: The Web of Science database was searched using terms relevant to "neuro-oncology." Articles with >400 citations were identified and the top 100 cited articles were evaluated...
May 20, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28525617/what-sways-people-s-judgement-of-sleep-quality-a-quantitative-choice-making-study-with-good-and-poor-sleepers
#3
Fatanah Ramlee, Adam N Sanborn, Nicole K Y Tang
Study objectives: We conceptualised sleep quality judgement as a decision-making process and examined the relative importance of 17 parameters of sleep quality using a choice-based conjoint analysis. Methods: 100 participants (50 good sleepers; 50 poor sleepers) were asked to choose between two written scenarios to answer one of two questions: "Which describes a better (or worse) night of sleep?". Each scenario described a subjective experience of sleep, stringing together 17 possible determinants of sleep quality that occur at different times of the day (day before, pre-sleep, during sleep, upon waking, day after)...
May 19, 2017: Sleep
https://www.readbyqxmd.com/read/28523478/anti-gpvi-fab-sar264565-effectively-blocks-gpvi-function-in-ex-vivo-human-platelets-under-arterial-shear-in-a-perfusion-chamber
#4
Peter Florian, Peter Wonerow, Sebastian Harder, Karina Kuczka, Michel Dubar, Jochen Graff
INTRODUCTION: Glycoprotein VI (GPVI) is the major platelet receptor for collagen-mediated platelet adhesion and activation. SAR264565 is an anti-GPVI-Fab, binds to GPVI with high affinity, and blocks GPVI function in human platelets in vitro. METHODS: The effect of SAR26456 on platelet responsiveness in the blood of 21 healthy male subjects was investigated using Sakariassen's ex vivo thrombogenesis perfusion chamber model on a collagen-coated surface under conditions mimicking arterial flow...
May 18, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28520233/nanojunction-polymer-photoelectrode-for-efficient-charge-transport-and-separation
#5
Qiushi Ruan, Wenjun Luo, Jijia Xie, Yiou Wang, Xu Liu, Zhiming Bai, Claire J Carmalt, Junwang Tang
A novel nanojunction archiecture of metal-free photoanode, composed of B-doped carbon nitride nanolayer and bulk carbon nitride has been fabricated by a one-step construction approach. This type of nanojunction overcomes a few intrinsic drawbacks of carbon nitride film, e.g. severe bulk charge recombination and slow charge transfer. For the optium sample, the top layer of the nanojunction has a depth of ca. 100 nm and the bottom layer is ca. 900 nm. The nanojunction photoanode results into a 10 fold higher photocurrent than bulk graphitic carbon nitride and an extremely high incident photon-to-current efficiency (IPCE) of ca...
May 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28516398/gynecological-brachytherapy-for-postoperative-endometrial-cancer-dosimetric-analysis-ir-192-vs-co-60
#6
V Tormo Ferrero, R Duque Ugarte, M Á Berenguer Francés, R Cardenal Maciá
INTRODUCTION: Endovaginal brachytherapy treatment dosimetry differences were studied using Ir-192 or Co-60 sources for postoperative endometrial cancer. MATERIALS AND METHODS: A prospective descriptive study was conducted. Thirty-six dosimetry plans of different patients were studied (15 by Ir-192 and 21 by Co-60). Variables studied included D2cc Rectum, D2cc Bladder, D2cc Sigmoid, dose percentage at point 0 (applicator surface on the top of the cylinder) and dose percentage at point 1 (5 mm deep on the top of the cylinder)...
May 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28515938/accounting-for-adjuvant-induced-artifacts-in-the-characterization-of-vaccine-formulations-by-polyacrylamide-gel-electrophoresis
#7
Virginie Jakob, Livia Brunner, Christophe Barnier-Quer, Molly Blust, Nicolas Collin, Lauren Carter, Darrick Carter, Kelly M Rausch, Christopher B Fox
OBJECTIVES: Several vaccine adjuvants comprise complex nano- or micro-particle formulations, such as oil-in-water emulsions. In order to characterize interactions and compatibility of oil-in-water emulsion adjuvants with protein antigens in vaccines, effective protein characterization methods that can accommodate potential interference from high concentrations of lipid-based particles are needed. METHODS: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is a standard protein characterization technique which is affected by the presence of adjuvants such as oil-in-water emulsions...
April 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28507426/performance-of-high-school-students-in-a-laparoscopic-training-program
#8
Scott Furer, Sarah Alam, James Rosser
BACKGROUND AND OBJECTIVES: We hypothesized that high school students can be subjected to the same laparoscopic surgical training curriculum used by surgeons and successfully complete it. The goal of this study was to evaluate the appropriateness of early training in minimally invasive surgical techniques. METHODS: Thirteen high school students, ages 15-18, participated in the validated Top Gun Surgeon Laparoscopic Skills and Suturing program. The students performed 3 preparatory drills 10 times each...
April 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28506381/description-of-drug-therapy-problem-resolution-in-a-statewide-care-management-program
#9
Chelsea Phillips Renfro, Stefanie P Ferreri, Neil Williams, Cole Clark, Trista Pfeiffenberger
OBJECTIVE: To describe drug therapy problem (DTP) resolution as part of a statewide, team-based care management program. METHODS: This was a retrospective, observational study of DTPs documented between March 1 and August 31, 2015. Data were retrieved from a Web-based platform 5 months after the observation period. DTPs were placed into groups based on the credentials of the person who documented the DTP. Next, they were identified as being documented in a transitional or nontransitional care setting...
May 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28502820/cancer-incidence-prevalence-and-mortality-in-the-oldest-old-a-comprehensive-review
#10
REVIEW
Shantell C Nolen, Marcella A Evans, Avital Fischer, Maria M Corrada, Claudia H Kawas, Daniela A Bota
Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world's top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease, whose risk has been proven to increase with age. Limited information is published about the epidemiology of cancer and the cancer contribution to mortality in the 85+ age group, often referred to as the oldest-old...
May 11, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28494039/top-cited-articles-in-implant-dentistry
#11
Anastasia Fardi, Konstantinos Kodonas, Theodoros Lillis, Alexander Veis
PURPOSE: Citation analysis is the field of bibliometrics that uses citation data to evaluate the scientific recognition and the influential performance of a research article in the scientific community. The aim of this study was to conduct a bibliometric analysis of the top-cited articles pertaining to implant dentistry, to analyze the main characteristics, and to display the most interesting topics and evolutionary trends. MATERIALS AND METHODS: The 100 top-cited articles published in "Dentistry, Oral Surgery, and Medicine" journals were identified using the Science Citation Index Database...
May 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28493979/tissue-lithography-microscale-dewaxing-to-enable-retrospective-studies-on-formalin-fixed-paraffin-embedded-ffpe-tissue-sections
#12
Julien F Cors, Aditya Kashyap, Anna Fomitcheva Khartchenko, Peter Schraml, Govind V Kaigala
We present a new concept, termed tissue lithography (TL), and its implementation which enables retrospective studies on formalin-fixed paraffin-embedded tissue sections. Tissue lithography uses a microfluidic probe to remove microscale areas of the paraffin layer on formalin-fixed paraffin-embedded biopsy samples. Current practices in sample utilization for research and diagnostics require complete deparaffinization of the sample prior to molecular testing. This imposes strong limitations in terms of the number of tests as well as the time when they can be performed on a single sample...
2017: PloS One
https://www.readbyqxmd.com/read/28493969/activation-and-inactivation-of-bacillus-pumilus-spores-by-kiloelectron-volt-x-ray-irradiation
#13
Thi Mai Hoa Ha, Derrick Yong, Elizabeth Mei Yin Lee, Prathab Kumar, Yuan Kun Lee, Weibiao Zhou
In this study, we investigated the inactivation efficacy of endospore-forming bacteria, Bacillus pumilus, irradiated by low-energy X-rays of different beam qualities. The different low-energy X-rays studied had cut-off energies of 50, 100 and 150 keV. Bacillus pumilus spores (in biological indicator strips) were irradiated at step doses between 6.5 to 390 Gy. The resulting bacteria populations were then quantified by a pour plate method. Results showed that X-rays of lower energies were more effective in inactivating bacterial spores...
2017: PloS One
https://www.readbyqxmd.com/read/28487265/effective-information-extraction-framework-for-heterogeneous-clinical-reports-using-online-machine-learning-and-controlled-vocabularies
#14
Shuai Zheng, James J Lu, Nima Ghasemzadeh, Salim S Hayek, Arshed A Quyyumi, Fusheng Wang
BACKGROUND: Extracting structured data from narrated medical reports is challenged by the complexity of heterogeneous structures and vocabularies and often requires significant manual effort. Traditional machine-based approaches lack the capability to take user feedbacks for improving the extraction algorithm in real time. OBJECTIVE: Our goal was to provide a generic information extraction framework that can support diverse clinical reports and enables a dynamic interaction between a human and a machine that produces highly accurate results...
May 9, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28487050/top-100-cited-articles-on-epilepsy-and-status-epilepticus-a-bibliometric-analysis
#15
REVIEW
Kang Min Park, Sung Eun Kim, Byung In Lee, Hyung Chan Kim, Dae Young Yoon, Hong Ki Song, Jong Seok Bae
The purpose of this study is to identify the top 100-cited articles dedicated to epilepsy and status epilepticus published in journals from January, 1950 through February, 2016 that have made key contributions in the field. We performed a search of journals and selected the top 100-cited articles on epilepsy and status epilepticus, respectively, by utilizing the Institute for Scientific Information database available under the banner of the Web of Science. The top-cited articles on epilepsy and status epilepticus were all published in 24 journals, respectively...
May 6, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28486356/epidemiologic-surveillance-of-teenage-birth-rates-in-the-united-states-2006-2012
#16
Raid Amin, Julie Zemaitis Decesare, Jennifer Hans, Kay Roussos-Ross
OBJECTIVE: To investigate the geographic variation in the average teenage birth rates by county in the contiguous United States. METHODS: Data from the National Center for Health Statistics were used in this retrospective cohort to count the total number of live births to females aged 15-19 years by county between 2006 and 2012. Software for disease surveillance and spatial cluster analysis was used to identify clusters of high or low teenage births in counties or areas of greater than 100,000 teenage females...
May 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28485127/clickable-microgel-scaffolds-as-platforms-for-3d-cell-encapsulation
#17
Alexander S Caldwell, Gavin T Campbell, Kelly M T Shekiro, Kristi S Anseth
While microporous scaffolds are increasingly used for regenerative medicine and tissue repair applications, the most common techniques to fabricate these scaffolds use templating or top-down fabrication approaches. Cytocompatible bottom-up assembly methods afford the opportunity to assemble microporous systems in the presence of cells and create complex polymer-cell composite systems in situ. Here, microgel building blocks with clickable surface groups are synthesized for the bottom-up fabrication of porous cell-laden scaffolds...
May 9, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28481981/socioeconomic-position-and-mortality-risk-of-smoking-evidence-from-the-english-longitudinal-study-of-ageing-elsa
#18
Dan Lewer, Martin McKee, Antonio Gasparrini, Aaron Reeves, Cesar de Oliveira
: It is not clear whether the harm associated with smoking differs by socioeconomic status. This study tests the hypothesis that smoking confers a greater mortality risk for individuals in low socioeconomic groups, using a cohort of 18 479 adults drawn from the English Longitudinal Study of Ageing. Additive hazards models were used to estimate the absolute smoking-related risk of death due to lung cancer or Chronic Obstructive Pulmonary Disease (COPD). Smoking was measured using a continuous index that incorporated the duration of smoking, intensity of smoking and the time since cessation...
May 7, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28480753/bibliometric-profile-of-deep-brain-stimulation
#19
Kejia Hu, Ziev B Moses, Wendong Xu, Ziv Williams
OBJECTIVE: We aimed to identify and analyze the characteristics of the 100 most highly-cited papers in the research field of deep brain stimulation (DBS). METHODS: The Web of Science was searched for highly-cited papers related to DBS research. The number of citations, countries, institutions of origin, year of publication, and research area were noted and analyzed. RESULTS: The 100 most highly-cited articles had a mean of 304.15 citations...
May 8, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28480506/county-level-cumulative-environmental-quality-associated-with-cancer-incidence
#20
Jyotsna S Jagai, Lynne C Messer, Kristen M Rappazzo, Christine L Gray, Shannon C Grabich, Danelle T Lobdell
BACKGROUND: Individual environmental exposures are associated with cancer development; however, environmental exposures occur simultaneously. The Environmental Quality Index (EQI) is a county-level measure of cumulative environmental exposures that occur in 5 domains. METHODS: The EQI was linked to county-level annual age-adjusted cancer incidence rates from the Surveillance, Epidemiology, and End Results (SEER) Program state cancer profiles. All-site cancer and the top 3 site-specific cancers for male and female subjects were considered...
May 8, 2017: Cancer
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