keyword
MENU ▼
Read by QxMD icon Read
search

Diagnostic error

keyword
https://www.readbyqxmd.com/read/28916249/diagnostic-errors-impact-of-an-educational-intervention-on-pediatric-primary-care
#1
Julianne Nemes Walsh, Margaret Knight, A James Lee
INTRODUCTION: The purpose of our study was to determine the impact of an educational program on a provider's knowledge related to diagnostic errors and diagnostic reasoning strategies. METHODS: A quasi-experimental interventional study with a multimedia approach, case study discussion, and trigger-generated medical record review at two time points was conducted. Measurement tools included a test developed by the National Patient Safety Foundation, Reducing Diagnostic Errors: Strategies for Solutions Quiz, additional diagnostic reasoning questions, and a trigger-generated process to analyze medical records...
September 12, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28915255/scrambled-eggs-a-highly-sensitive-molecular-diagnostic-workflow-for-fasciola-species-specific-detection-from-faecal-samples
#2
Nichola Eliza Davies Calvani, Peter Andrew Windsor, Russell David Bush, Jan Šlapeta
BACKGROUND: Fasciolosis, due to Fasciola hepatica and Fasciola gigantica, is a re-emerging zoonotic parasitic disease of worldwide importance. Human and animal infections are commonly diagnosed by the traditional sedimentation and faecal egg-counting technique. However, this technique is time-consuming and prone to sensitivity errors when a large number of samples must be processed or if the operator lacks sufficient experience. Additionally, diagnosis can only be made once the 12-week pre-patent period has passed...
September 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28912133/use-of-crispr-modified-human-stem-cell-organoids-to-study-the-origin-of-mutational-signatures-in-cancer
#3
Jarno Drost, Ruben van Boxtel, Francis Blokzijl, Tomohiro Mizutani, Nobuo Sasaki, Valentina Sasselli, Joep de Ligt, Sam Behjati, Judith E Grolleman, Tom van Wezel, Serena Nik-Zainal, Roland P Kuiper, Edwin Cuppen, Hans Clevers
Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology, and hold diagnostic and prognostic value. Here, we develop a strategy that can be used to explore the origin of cancer-associated mutational signatures. We used CRISPR/Cas9 technology to delete key DNA repair genes in human colon organoids, followed by delayed sub-cloning and whole-genome sequencing. We found that mutation accumulation in organoids deficient in the mismatch repair gene MLH1 is driven by replication errors and accurately models the mutation profiles observed in mismatch repair-deficient colorectal cancers...
September 14, 2017: Science
https://www.readbyqxmd.com/read/28910160/a-novel-approach-to-the-differentiation-of-intrabulbar-tumors-in-color-doppler-imaging
#4
Monika Modrzejewska, Marta P Wiącek
AIM OF THE STUDY: The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic of choroidal melanoma and metastatic intrabulbar tumors, increasing the diagnostic value and giving a new insight into the use of this method. MATERIALS AND METHODS: CDI was performed in 44 patients with malignant tumors and in 49 patients with benign tumors...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28906245/potential-audiological-and-mri-markers-of-tinnitus
#5
Kamakshi V Gopal, Binu P Thomas, Rajesh Nandy, Deng Mao, Hanzhang Lu
BACKGROUND: Subjective tinnitus, or ringing sensation in the ear, is a common disorder with no accepted objective diagnostic markers. PURPOSE: The purpose of this study was to identify possible objective markers of tinnitus by combining audiological and imaging-based techniques. RESEARCH DESIGN: Case-control studies. STUDY SAMPLE: Twenty adults drawn from our audiology clinic served as participants. The tinnitus group consisted of ten participants with chronic bilateral constant tinnitus, and the control group consisted of ten participants with no history of tinnitus...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28904678/-epidemiological-profile-of-hemoglobinopathies-a-cross-sectional-and-descriptive-index-case-study
#6
Fatima Dahmani, Souad Benkirane, Jaafar Kouzih, Aziz Woumki, Hassan Mamad, Azlarab Masrar
Hemoglobinopathies are congenital disorders resultimg from hemoglobin abnormalities. Major forms are often severe, their management is difficult and associated with a great psychosocial impact on patients and their families. They are classified as rare diseases and are still insufficiently known by health professionals. This lack of knowledge is at the origin of diagnostic errors, delay in their management and therefore high morbidity and mortality rate for these patients. In 2008, the World Health Organization (WHO) has published data on hemoglobinopathies epidemiology: more than 330...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903861/a-decision-support-system-and-rule-based-algorithm-to-augment-the-human-interpretation-of-the-12-lead-electrocardiogram
#7
Andrew W Cairns, Raymond R Bond, Dewar D Finlay, Daniel Guldenring, Fabio Badilini, Guido Libretti, Aaron J Peace, Stephen J Leslie
BACKGROUND: The 12-lead Electrocardiogram (ECG) has been used to detect cardiac abnormalities in the same format for more than 70years. However, due to the complex nature of 12-lead ECG interpretation, there is a significant cognitive workload required from the interpreter. This complexity in ECG interpretation often leads to errors in diagnosis and subsequent treatment. We have previously reported on the development of an ECG interpretation support system designed to augment the human interpretation process...
August 9, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28902615/irregular-analytical-errors-in-diagnostic-testing-a-novel-concept
#8
Michael Vogeser, Christoph Seger
BACKGROUND: In laboratory medicine, routine periodic analyses for internal and external quality control measurements interpreted by statistical methods are mandatory for batch clearance. Data analysis of these process-oriented measurements allows for insight into random analytical variation and systematic calibration bias over time. However, in such a setting, any individual sample is not under individual quality control. The quality control measurements act only at the batch level. Quantitative or qualitative data derived for many effects and interferences associated with an individual diagnostic sample can compromise any analyte...
September 13, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28899843/a-machine-learning-approach-for-the-identification-of-new-biomarkers-for-knee-osteoarthritis-development-in-overweight-and-obese-women
#9
N Lazzarini, J Runhaar, A C Bay-Jensen, C S Thudium, S M A Bierma-Zeinstra, Y Henrotin, J Bacardit
OBJECTIVE: Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease. Furthermore, the available diagnostic approaches have large precision errors and low sensitivity. Therefore, there is a need for new biomarkers to correctly identify early knee OA. METHOD: We have created an analytics pipeline based on machine learning to identify small models (having few variables) that predict the 30-months incidence of knee OA (using multiple clinical and structural OA outcome measures) in overweight middle-aged women without knee OA at baseline...
September 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28891596/external-evaluation-of-population-pharmacokinetic-models-for-cyclosporine-in-adult-renal-transplant-recipients
#10
Jun-Jun Mao, Zheng Jiao, Hwi-Yeol Yun, Chen-Yan Zhao, Han-Chao Chen, Xiao-Yan Qiu, Ming-Kang Zhong
AIM: Several population pharmacokinetic (popPK) models for cyclosporine (CsA) in adult renal transplant recipients have been constructed to optimise the therapeutic regimen of CsA. However, little is known about their predictabilities when extrapolated to different clinical centres. Therefore, this study aimed to externally evaluate the predictive ability of CsA popPK models and determine the potential influencing factors. METHODS: A literature search was conducted and the predictive performance was determined for each selected model using an independent data set of 62 patients (471 pre-dose and 500 2-hour post-dose concentrations) from our hospital...
September 11, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28887783/a-novel-integration-of-spectral-domain-optical-coherence-tomography-and-laser-ablation-system-for-precision-treatment
#11
Yingwei Fan, Boyu Zhang, Wei Chang, Xinran Zhang, Hongen Liao
PURPOSE: Complete resection of diseased lesions reduces the recurrence of cancer, making it critical for surgical treatment. However, precisely resecting residual tumors is a challenge during operation. A novel integrated spectral-domain optical-coherence-tomography (SD-OCT) and laser-ablation therapy system for soft-biological-tissue resection is proposed. This is a prototype optical integrated diagnosis and therapeutic system as well as an optical theranostics system. METHODS: We develop an optical theranostics system, which integrates SD-OCT, a laser-ablation unit, and an automatic scanning platform...
September 9, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28884486/are-sound-abatement-measures-necessary-in-the-cytology-reading-room-a-study-of-auditory-distraction
#12
A Evered, A Watt, N Perham
OBJECTIVE: Listening to music and other auditory material during microscopy work is common practice among cytologists. While many cytologists would claim several benefits of such activity, research in other fields suggests that it might adversely affect diagnostic performance. Using a cross-modal distraction paradigm, the aim of the present study was to investigate the effect of auditory stimulation on the visual interpretation of cell images. METHODS: Following initial training, 34 participants undertook cell interpretation tests under four auditory conditions (liked music, disliked music, speech and silence) in a counterbalanced repeated-measures study...
September 7, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28882497/pulmonary-vein-isolation-for-atrial-fibrillation-can-be-achieved-with-low-radiation-exposure
#13
Alex L Huang, Nadeem Mughal, Ferdinand Tabas, Natalie L Patterson, Wen Kai Wong, David Whalley, Logan Kanagaratnam
BACKGROUND: Atrial fibrillation is common and management by pharmacotherapy is limited by modest efficacy and significant toxicities. Pulmonary vein isolation (PVI) is a safe and effective alternative in select patients with atrial fibrillation. However, prolonged procedure time raises concerns of health risks from radiation exposure. This study aims to determine the significance of radiation exposure from PVI. METHODS: In this study, we retrospectively reviewed patient demographics, fluoroscopy time, entrance skin dose and dose area product in 80 cases of PVI, radiofrequency ablation for atrial flutter and diagnostic coronary angiogram performed in our institution...
August 8, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28879147/laboratory-test-result-interpretation-for-primary-care-doctors-in-south-africa
#14
Naadira Vanker, Norman H B Faull
BACKGROUND: Challenges and uncertainties with test result interpretation can lead to diagnostic errors. Primary care doctors are at a higher risk than specialists of making these errors, due to the range in complexity and severity of conditions that they encounter. OBJECTIVES: This study aimed to investigate the challenges that primary care doctors face with test result interpretation, and to identify potential countermeasures to address these. METHODS: A survey was sent out to 7800 primary care doctors in South Africa...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28878384/combination-of-optical-coherence-tomography-and-near-infrared-spectroscopy-enhances-determination-of-articular-cartilage-composition-and-structure
#15
Jaakko K Sarin, Lassi Rieppo, Harold Brommer, Isaac O Afara, Simo Saarakkala, Juha Töyräs
Conventional arthroscopic evaluation of articular cartilage is subjective and poorly reproducible. Therefore, implementation of quantitative diagnostic techniques, such as near infrared spectroscopy (NIRS) and optical coherence tomography (OCT), is essential. Locations (n = 44) with various cartilage conditions were selected from mature equine fetlock joints (n = 5). These locations and their surroundings were measured with NIRS and OCT (n = 530). As a reference, cartilage proteoglycan (PG) and collagen contents, and collagen network organization were determined using quantitative microscopy...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877918/very-deep-convolutional-neural-networks-for-morphologic-classification-of-erythrocytes
#16
Thomas J S Durant, Eben M Olson, Wade L Schulz, Richard Torres
BACKGROUND: Morphologic profiling of the erythrocyte population is a widely used and clinically valuable diagnostic modality, but one that relies on a slow manual process associated with significant labor cost and limited reproducibility. Automated profiling of erythrocytes from digital images by capable machine learning approaches would augment the throughput and value of morphologic analysis. To this end, we sought to evaluate the performance of leading implementation strategies for convolutional neural networks (CNNs) when applied to classification of erythrocytes based on morphology...
September 6, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28877186/proof-of-concept-of-a-45-second-cardiorespiratory-fitness-self-test-for-coronary-artery-disease-patients-based-on-accelerometry
#17
Gabriele Papini, Alberto G Bonomi, Wim Stut, Jos J Kraal, Hareld M C Kemps, Francesco Sartor
Cardiorespiratory fitness (CRF) provides important diagnostic and prognostic information. It is measured directly via laboratory maximal testing or indirectly via submaximal protocols making use of predictor parameters such as submaximal [Formula: see text], heart rate, workload, and perceived exertion. We have established an innovative methodology, which can provide CRF prediction based only on body motion during a periodic movement. Thirty healthy subjects (40% females, 31.3 ± 7.8 yrs, 25.1 ± 3.2 BMI) and eighteen male coronary artery disease (CAD) (56...
2017: PloS One
https://www.readbyqxmd.com/read/28875029/validation-of-experimental-charge-density-refinement-strategies-when-do-we-overfit
#18
Lennard Krause, Benedikt Niepötter, Christian J Schürmann, Dietmar Stalke, Regine Herbst-Irmer
A cross-validation method is supplied to judge between various strategies in multipole refinement procedures. Its application enables straightforward detection of whether the refinement of additional parameters leads to an improvement in the model or an overfitting of the given data. For all tested data sets it was possible to prove that the multipole parameters of atoms in comparable chemical environments should be constrained to be identical. In an automated approach, this method additionally delivers parameter distributions of k different refinements...
July 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28872917/a-post-hoc-subgroup-analysis-of-outcomes-in-the-first-phase-iii-clinical-study-of-edaravone-mci-186-in-amyotrophic-lateral-sclerosis
#19
(no author information available yet)
Our first phase III study failed to demonstrate efficacy of edaravone for amyotrophic lateral sclerosis (ALS) compared to placebo. Here, we performed post-hoc subgroup analysis to identify a subgroup in which edaravone might be expected to show efficacy. We focussed on two newly defined subgroups, EESP and dpEESP2y. The EESP was defined as the efficacy-expected subpopulation with % forced vital capacity of ≥80%, and ≥2 points for all item scores in the revised ALS functional rating scale (ALSFRS-R) score before treatment...
October 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28872527/muscle-microvascular-blood-flow-oxygenation-ph-and-perfusion-pressure-decrease-in-simulated-acute-compartment-syndrome
#20
Sravya T Challa, Alan R Hargens, Amarachi Uzosike, Brandon R Macias
BACKGROUND: The current gold standard for diagnosing acute compartment syndrome (ACS) is an assessment of clinical signs, invasive measurement of intramuscular pressure (IMP), and measurement of local perfusion pressure. However, IMP measurements have several shortcomings, including pain, risk of infection, risk of technique error, plugging of the catheter tip, lack of consensus on the diagnostic pressure threshold, and lack of specificity and sensitivity. The objective of this study was to evaluate muscle hemodynamics, oxygenation, and pH as diagnostic parameters in a human model of ACS...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
keyword
keyword
8702
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"