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https://www.readbyqxmd.com/read/28431096/a-new-rapid-resazurin-based-microdilution-assay-for-antimicrobial-susceptibility-testing-of-neisseria-gonorrhoeae
#1
Sunniva Foerster, Valentino Desilvestro, Lucy J Hathaway, Christian L Althaus, Magnus Unemo
Objectives: Rapid, cost-effective and objective methods for antimicrobial susceptibility testing of Neisseria gonorrhoeae would greatly enhance surveillance of antimicrobial resistance. Etest, disc diffusion and agar dilution methods are subjective, mostly laborious for large-scale testing and take ∼24 h. We aimed to develop a rapid broth microdilution assay using resazurin (blue), which is converted into resorufin (pink fluorescence) in the presence of viable bacteria. Methods: The resazurin-based broth microdilution assay was established using 132 N...
April 19, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28429200/achalasia-it-is-not-all-black-and-white
#2
REVIEW
Santosh Sanagapalli, Rami Sweis
PURPOSE OF REVIEW: This review aims to shed light on subtleties of achalasia diagnosis, including potential pitfalls that may lead to errors. Optimal methods for assessment of disease severity and the relationship between achalasia and other motility disorders will also be reviewed with an emphasis on recent findings from the literature. RECENT FINDINGS: Adjunctive testing with viscous substances or larger water volumes should be used routinely as it improves the accuracy of achalasia diagnosis...
June 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28427482/a-genetic-variant-brain-dervied-neurotrophic-factor-bdnf-polymorphism-interacts-with-hostile-parenting-to-predict-error-related-brain-activity-and-thereby-risk-for-internalizing-disorders-in-children
#3
Alexandria Meyer, Greg Hajcak, Elizabeth Hayden, Haroon I Sheikh, Shiva M Singh, Daniel N Klein
The error-related negativity (ERN) is a negative deflection in the event-related potential occurring when individuals make mistakes, and is increased in children with internalizing psychopathology. We recently found that harsh parenting predicts a larger ERN in children, and recent work has suggested that variation in the brain-derived neurotrophic factor (BDNF) gene may moderate the impact of early life adversity. Parents and children completed measures of parenting when children were 3 years old (N = 201); 3 years later, the ERN was measured and diagnostic interviews as well as dimensional symptom measures were completed...
April 21, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28424090/targeted-endomyocardial-biopsy-guided-by-real-time-cardiovascular-magnetic-resonance
#4
Christina Unterberg-Buchwald, Christian Oliver Ritter, Verena Reupke, Robin Niklas Wilke, Christine Stadelmann, Michael Steinmetz, Andreas Schuster, Gerd Hasenfuß, Joachim Lotz, Martin Uecker
BACKGROUND: Endomyocardial biopsies (EMB) are an important diagnostic tool for myocarditis and other infiltrative cardiac diseases. Routinely, biopsies are obtained under fluoroscopic guidance with a substantial radiation burden. Despite procedural success, there is a large sampling error caused by missing the affected myocardium. Therefore, multiple (>6) biopsies are taken in the clinical setting. In cardiovascular magnetic resonance (CMR), late gadolinium enhancement (LGE) depicts areas of affected myocardium in myocarditis or in other infiltrative cardiomyopathies...
April 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28424035/coexistence-of-tuberculosis-and-malignancy-a-mere-coincidence-or-a-causal-association
#5
Mukta Pujani, Zeeba S Jairajpuri, Sabina Khan, Mohd Jaseem Hassan, Sujata Jetley, Safia Rana
Tuberculosis (TB) and malignancy are among the most important current global health problems. Many authors suggest that their coexistence is a chance association owing to their high prevalence. There is, however, enough evidence that one condition may predispose the other. In our retrospective report of two cases, TB in draining lymph nodes was discovered incidentally on histopathology, following surgical resection for malignancy. The possibility of coexistent lesions, especially in regions endemic for TB, mandate a detailed histopathological examination to prevent the chances of diagnostic failure and thus therapeutic error...
April 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28417544/urine-biomarkers-of-acute-kidney-injury-in-noncritically-ill-hospitalized-children-treated-with-chemotherapy
#6
Maya Sterling, Zubaida Al-Ismaili, Kelly R McMahon, Melissa Piccioni, Michael Pizzi, Theresa Mottes, Larry C Lands, Sharon Abish, Adam J Fleming, Michael R Bennett, Ana Palijan, Prasad Devarajan, Stuart L Goldstein, Maureen M O'Brien, Michael Zappitelli
BACKGROUND: Cisplatin (Cis), carboplatin (Carb), and ifosfamide (Ifos) are common nephrotoxic chemotherapies. Biomarkers of tubular injury may allow for early acute kidney injury (AKI) diagnosis. PROCEDURE: We performed a two-center (Canada, United States) pilot study to prospectively measure serum creatinine (SCr), urine neutrophil gelatinase-associated lipocalin (NGAL), and interleukin-18 (IL-18) in children receiving Cis/Carb (27 episodes), Ifos (30 episodes), and in 15 hospitalized, nonchemotherapy patients...
April 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28410544/does-respiratory-variation-in-inferior-vena-cava-diameter-predict-fluid-responsiveness-a-systematic-review-and-meta-analysis
#7
Elliot Long, Ed Oakley, Trevor Duke, Franz E Babl
BACKGROUND: The aim of fluid resuscitation is to increase stroke volume, yet this effect is observed in only 50% of patients. Prediction of fluid responsiveness may allow fluid resuscitation to be administered to those most likely to benefit. The aim of this study was to systematically review the test characteristics of respiratory variation in inferior vena cava (IVC) diameter as a predictor of fluid responsiveness in patients with acute circulatory failure. METHODS: Electronic searches combined with reference review of identified studies...
May 2017: Shock
https://www.readbyqxmd.com/read/28410101/medical-instrument-detection-in-3-dimensional-ultrasound-data-volumes
#8
Arash Pourtaherian, Harm Scholten, Lieneke Kusters, Svitlana Zinger, Nenad Mihajlovic, Alexander Kolen, Fei Zou, Gary Ng, Hendrikus Korsten, Peter de With
Ultrasound-guided medical interventions are broadly applied in diagnostics and therapy, e.g. regional anesthesia or ablation. A guided intervention using 2D ultrasound is challenging due to the poor instrument visibility, limited field of view and the multi-fold coordination of the medical instrument and ultrasound plane. Recent 3D ultrasound transducers can improve the quality of the image-guided intervention if an automated detection of the needle is used. In this paper, we present a novel method for detecting medical instruments in 3D ultrasound data that is solely based on image processing techniques and validated on various ex-vivo and in-vivo datasets...
April 7, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28409852/tandem-mass-spectrometric-analysis-of-novel-peptide-modified-gemini-surfactants-used-as-gene-delivery-vectors
#9
Mays Al-Dulaymi, Anas El-Aneed
Diquaternary ammonium gemini Surfactants have emerged as effective gene delivery vectors. A novel series of eleven peptide-modified compounds was synthesized, showing promising results in delivering genetic materials. The purpose of this work is to elucidate the tandem mass spectrometric (MS/MS) dissociation behaviour of these novel molecules establishing a generalized MS/MS fingerprint. Exact mass measurements were achieved using a hybrid quadrupole orthogonal time-of-flight mass spectrometer (QqToF-MS) and a multi-stage tandem mass spectrometric analysis was conducted using a triple quadrupole-linear ion trap mass spectrometer (QqQLIT-MS)...
April 14, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28409627/simultaneous-atr-ftir-based-determination-of-malaria-parasitemia-glucose-and-urea-in-whole-blood-dried-onto-a-glass-slide
#10
Supti Roy, David Perez-Guaita, Dean W Andrew, Jack S Richards, Don McNaughton, Philip Heraud, Bayden R Wood
New diagnostic tools that can detect malaria parasites in conjunction with other diagnostic parameters are urgently required. In this study, Attenuated Total Reflection Fourier transform infrared (ATR-FTIR) spectroscopy in combination with Partial Least Square Discriminant Analysis (PLS-DA) and Partial Least Square Regression (PLS-R) have been applied as a point-of-care test for identifying malaria parasites, blood glucose and urea levels in whole blood samples from thick blood films on glass slides. The specificity for the PLS-DA was found to be 98 % for parasitemia levels >0...
April 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28409357/diffusion-weighted-mri-to-assess-response-to-chemoradiotherapy-in-rectal-cancer-main-interpretation-pitfalls-and-their-use-for-teaching
#11
Doenja M J Lambregts, Miriam M van Heeswijk, Andrea Delli Pizzi, Saskia G C van Elderen, Luisa Andrade, Nicky H G M Peters, Peter A M Kint, Margreet Osinga-de Jong, Shandra Bipat, Rik Ooms, Max J Lahaye, Monique Maas, Geerard L Beets, Frans C H Bakers, Regina G H Beets-Tan
OBJECTIVES: To establish the most common image interpretation pitfalls for non-expert readers using diffusion-weighted imaging (DWI) to assess response to chemoradiotherapy in patients with rectal cancer and to explore the use of these pitfalls in an expert teaching setting. METHODS: Two independent non-expert readers (R1 and R2) scored the restaging DW MRI scans (b1,000 DWI, in conjunction with ADC maps and T2-W MRI scans for anatomical reference) in 100 patients for the likelihood of a complete response versus residual tumour using a five-point confidence score...
April 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28408990/endoscopic-modalities-for-the-diagnosis-of-barrett-s-oesophagus
#12
REVIEW
Neel Sharma, Supriya Srivastava, Florian Kern, Wa Xian, Teh Ming, Frank McKeon, Khek Yu Ho
Barrett's oesophagus is a pre-malignant condition associated with the development of oesophageal adenocarcinoma. Currently white light endoscopy and biopsy is the mainstay diagnostic tool. Yet this approach is troubled by issues related to cumbersome biopsy sampling, biopsy sampling errors and cost. Therefore in order to overcome such adversity, there needs to be evolutionary advancement in terms of diagnosis, which should address these concerns and ideally enhance risk stratification in order to provide timely management in real time...
December 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28406682/overcoming-indecision-by-changing-the-decision-boundary
#13
Gaurav Malhotra, David S Leslie, Casimir J H Ludwig, Rafal Bogacz
The dominant theoretical framework for decision making asserts that people make decisions by integrating noisy evidence to a threshold. It has recently been shown that in many ecologically realistic situations, decreasing the decision boundary maximizes the reward available from decisions. However, empirical support for decreasing boundaries in humans is scant. To investigate this problem, we used an ideal observer model to identify the conditions under which participants should change their decision boundaries with time to maximize reward rate...
April 13, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28406553/detection-of-factor-xiii-deficiency-data-from-multicentre-exercises-amongst-uk-neqas-and-pro-rbdd-project-laboratories
#14
I Jennings, S Kitchen, M Menegatti, R Palla, I Walker, M Makris, F Peyvandi
INTRODUCTION: FXIII deficiency is a rare bleeding disorders, and specific FXIII assays are recommended to detect this deficiency. We investigated the performance and accuracy of FXIII investigations in two exercises, comparing centres enrolled in the PRO-RBDD project (prospective data collection on patients with fibrinogen and Factor XIII deficiencies), and UK NEQAS BC centres. METHODS: Samples from a FXIII deficient subject and a normal donor were sent to participating centres, to investigate for FXIII deficiency, and interpret their results...
April 13, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28405947/accuracy-and-reliability-of-infrared-thermography-in-assessment-of-the-breasts-of-women-affected-by-cancer
#15
Rinaldo Roberto de Jesus Guirro, Maíta Marade Oliveira Lima Leite Vaz, Lais Mara Siqueira das Neves, Almir Vieira Dibai-Filho, Hélio Humberto Angotti Carrara, Elaine Caldeira de Oliveira Guirro
Evaluate reliability and accuracy of infrared thermography in the assessment of women wth breasts cancer. Thirty-five participants had unilateral breast cancer and 17 control subjects were assessed using infrared thermography. To evaluate reliability, two professionals, who were experienced, measured the temperature of the infrared images in two different moments, with a one-week interval. Biopsy was used as a gold standard exam with regard identify breast cancer. The analysis illustrated excellent reliability in terms of the affected, contralateral and control breasts with the intra-class correlation coefficient values ranging from 0...
May 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28402605/biotin-thiamine-responsive-basal-ganglia-disease-identification-of-a-pyruvate-peak-on-brain-spectroscopy-novel-mutation-in-slc19a3-and-calculation-of-prevalence-based-on-allele-frequencies-from-aggregated-next-generation-sequencing-data
#16
Carlos R Ferreira, Matthew T Whitehead, Eyby Leon
Biotin-thiamine responsive basal ganglia disease is an inborn error of metabolism caused by mutations in SLC19A3, encoding a transporter of thiamine across the plasma membrane. We report a novel mutation identified in the homozygous state in a patient with typical brain MRI changes. In addition, this patient had markedly elevated CSF pyruvate, a low lactate-to-pyruvate molar ratio, and an abnormal pyruvate peak at 2.4 ppm on brain magnetic resonance spectroscopy. Using aggregated exome sequencing data, we calculate the carrier frequency of mutations in SLC19A3 as 1 in 232 individuals in the general population, for an estimated prevalence of the disease of approximately 1 in 215,000 individuals...
April 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28399928/australian-children-living-with-rare-diseases-experiences-of-diagnosis-and-perceived-consequences-of-diagnostic-delays
#17
Yvonne Zurynski, Marie Deverell, Troy Dalkeith, Sandra Johnson, John Christodoulou, Helen Leonard, Elizabeth J Elliott
BACKGROUND: Children and families living with rare disease often experience significant health, psychosocial, economic burdens and diagnostic delays. Experiences appear to be constant, regardless of the specific rare disease diagnosis. Systematically collected Australian data to support policy response on rare diseases are scarce. We address this gap by providing survey results about 462 children aged <19 years living with approximately 200 different rare diseases. RESULTS: Of 462 children, 96% were born in Australia, 55% were male, median age was 8...
April 11, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28399087/-the-ophthalmological-complications-encountered-in-the-practical-work-of-the-plastic-surgeons-during-preparation-and-performance-of-blepharoplastic-interventions
#18
A A Gusarov, V A Fetisov, N M Sol'nov, E I Karpova
The article presents the results of a commission inspection of the results of the forensic medical expertise performed by the specialists of a state-owned forensic medical bureau in connection with the civil case concerning the judicial appeal of the 58 year-old suitress S. against a private plastic surgery clinic. It is shown that the carelessness of the surgeons with the fact of chronic diseases in the patient and the application of the vasoconstrictor medications during the surgical treatment (blepharoplasty) resulted in optic nerve atrophy in the immediate postoperative period with the complete loss of vision in the only seeing eye...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28396063/-morel-lavall%C3%A3-e-syndrome-and-post-traumatic-nodular-fat-necrosis-two-post-traumatic-complications-mimicking-cellulitis
#19
C Moulin, I Barthélémy, C Emering, M D'Incan
BACKGROUND: Dermal and subcutaneous inflammation following direct trauma is initially evocative of soft-tissue infection. However, two differential diagnoses must be considered: Morel-Lavallée syndrome and post-traumatic nodular fat necrosis. PATIENTS AND METHODS: Case 1: a 51-year-old woman fell off her motorbike and had dermabrasions on her right and left tibial ridges that rapidly developed into dermo-hypodermitis of the entire limb. There was no improvement after 3 weeks of antibiotics...
April 7, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28392728/external-quality-assessment-beyond-the-analytical-phase-an-australian-perspective
#20
REVIEW
Tony Badrick, Stephanie Gay, Euan J McCaughey, Andrew Georgiou
External Quality Assessment (EQA) is the verification, on a recurring basis, that laboratory results conform to expectations for the quality required for patient care. It is now widely recognised that both the pre- and post-laboratory phase of testing, termed the diagnostic phases, are a significant source of laboratory errors. These errors have a direct impact on both the effectiveness of the laboratory and patient safety. Despite this, Australian laboratories tend to be focussed on very narrow concepts of EQA, primarily surrounding test accuracy, with little in the way of EQA programs for the diagnostic phases...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
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