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triamcinolone in urethral strictures

Omer Kurt, Fethullah Gevher, Cenk Murat Yazici, Mustafa Erboga, Mucahit Dogru, Cevat Aktas
Urethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0...
September 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Rishi Modh, Peter Y Cai, Alyssa Sheffield, Lawrence L Yeung
Objective. To evaluate the recurrence rate of bulbar urethral strictures managed with cold knife direct vision internal urethrotomy and high dose corticosteroid injection. Methods. 28 patients with bulbar urethral strictures underwent direct vision internal urethrotomy with high dose triamcinolone injection into the periurethral tissue and were followed up for recurrence. Results. Our cohort had a mean age of 60 years and average stricture length of 1.85 cm, and 71% underwent multiple previous urethral stricture procedures with an average of 5...
2015: Advances in Urology
Stella L Ivaz, Rajan Veeratterapillay, Matthew J Jackson, Christopher K Harding, Trevor J Dorkin, Daniela E Andrich, Anthony R Mundy
BACKGROUND: Intermittent self-dilatation (ISD) may be recommended to reduce the risk of recurrent urethral stricture. Level one evidence to support the use of this intervention is lacking. OBJECTIVES: Determine the clinical and cost-effectiveness of ISD for the management of urethral stricture disease in males. SEARCH METHODS: The strategy developed for the Cochrane Incontinence Review Group as a whole (last searched May 7, 2014). SELECTION CRITERIA: Randomised trials where one arm was a programme of ISD for urethral stricture...
September 2016: Neurourology and Urodynamics
Osman Ergün, Ahmet Güzel, Abdullah Armağan, Alim Koşar, Ayşe Gül Ergün
PURPOSE: Our aim was to evaluate clean intermittent catheterization (CIC) results in combination with triamcinolone ointment and contractubex ointment for lubrication of the catheter after optical internal urethrotomy (OIU). METHODS: Ninety patients who underwent OIU were randomized into three groups. Two weeks after operation, patients were treated with CIC (group A), triamcinolone ointment CIC (group B), and contractubex ointment CIC (group C). Follow-up continued for 24 months after the OIU...
June 2015: International Urology and Nephrology
Matthew J Jackson, Rajan Veeratterapillay, Chris K Harding, Trevor J Dorkin
BACKGROUND: Intermittent urethral self-dilatation is sometimes recommended to reduce the risk of recurrent urethral stricture. There is no consensus as to whether it is a clinically effective or cost-effective intervention in the management of this disease. OBJECTIVES: The purpose of this review is to evaluate the clinical effectiveness and cost-effectiveness of intermittent self-dilatation after urethral stricture surgery in males compared to no intervention. We also compared different programmes of, and devices for, intermittent self-dilatation...
2014: Cochrane Database of Systematic Reviews
Santosh Kumar, Nitin Garg, Shrawan Kumar Singh, Arup Kumar Mandal
Purpose. To study the efficacy of optical internal urethrotomy with intralesional injection of Vatsala-Santosh PGI tri-inject (triamcinolone, mitomycin C, and hyaluronidase) in the treatment of anterior urethral stricture. Material and Methods. A total of 103 patients with symptomatic anterior urethral stricture were evaluated on the basis of clinical history, physical examination, uroflowmetry, and retrograde urethrogram preoperatively. All patients were treated with optical internal urethrotomy followed by injection of tri-inject at the urethrotomy site...
2014: Advances in Urology
Santosh Kumar, Ankur Kapoor, Raguram Ganesamoni, Bhuvanesh Nanjappa, Varun Sharma, Uttam K Mete
PURPOSE: To evaluate the outcome of visual internal urethrotomy with a holmium:yttrium-aluminum-garnet laser along with intralesional triamcinolone injection. MATERIALS AND METHODS: Patients with an anterior urethral stricture less than 3 cm in length were evaluated by clinical history, physical examination, uroflowmetry, and retrograde urethrogram preoperatively. All patients were treated with holmium laser urethrotomy and intralesional triamcinolone (80 mg) injection under general or regional anesthesia...
September 2012: Korean Journal of Urology
Adnan Gücük, Can Tuygun, Berk Burgu, Ufuk Oztürk, Onur Dede, Abdurrahim Imamoğlu
PURPOSE: To present the short-term results of hydrophilic dilatation catheter or steroid-coated hydrophilic dilatation catheter usage in the management of primary urethral stricture. PATIENTS AND METHODS: Forty-five male patients with a diagnosis of primary urethral stricture shorter than 1.5 cm and no comorbities were included in this study. After application of visual internal uretrotomy interna, these patients were randomized into three groups. A steroid-coated (triamcinolone acetonide 1%) 18F hydrophilic dilatation catheter was applied to the patients in group 1 for 2 weeks and an 18F hydrophilic dilatation catheter was applied to the patients in group 2 for 2 weeks...
June 2010: Journal of Endourology
Hamid Mazdak, Mohammad Hossein Izadpanahi, Asghar Ghalamkari, Mahmoud Kabiri, Mohammad-Hatef Khorrami, Kia Nouri-Mahdavi, Farshid Alizadeh, Mahtab Zargham, Farhad Tadayyon, Ahmad Mohammadi, Mohammad Yazdani
OBJECTIVES: In clinical practice, internal urethrotomy is an easy procedure and is offered as a first modality for treatment of short urethral strictures. Internal urethrotomy refers to any procedure that opens the stricture by incising or ablating it transurethrally. The most common complication of internal urethrotomy is stricture recurrence. The curative success rate of internal urethrotomy is approximately 20%. Triamcinolone has antifibroblast and anticollagen properties. This study evaluated the efficacy of triamcinolone in the prevention of anterior urethral stricture recurrence after internal urethrotomy...
September 2010: International Urology and Nephrology
Jalil Hosseini, Ali Kaviani, Ali Reza Golshan
INTRODUCTION: Our aim was to evaluate clean intermittent catheterization (CIC) results in combination with triamcinolone ointment for lubrication of the catheter after internal urethrotomy. MATERIALS AND METHODS: Seventy patients who underwent internal urethrotomy were assigned into 2 groups and performed CIC with either triamcinolone 1% ointment or a water-based gel (control) for lubrication of the catheter. They continued CIC regimen up to 6 month and were followed up for 12 months...
2008: Urology Journal
Stefan Kamp, Thomas Knoll, Mahmoud M Osman, Kai Uwe Köhrmann, Maurice S Michel, Peter Alken
PURPOSE: To evaluate the efficacy of endourethrotomy with the holmium:YAG laser as a minimally invasive treatment for urethral stricture. PATIENTS AND METHODS: Between January 2002 and January 2004, 32 male patients with symptomatic urethral strictures (8 bulbar, 9 penile, 9 combined) were treated with Ho:YAG-laser urethrotomy in our department. The stricture was iatrogenic in 60% (N = 18), inflammatory in 16.6% (N = 5), traumatic in 13.3% (N = 4), and idiopathic in 7% (N = 3)...
January 2006: Journal of Endourology
Marie Norredam, Sondra Crosby, Ricardo Munarriz, Lin Piwowarczyk, Michael Grodin
OBJECTIVES: To describe the urologic and sexual complications of male survivors of sexual torture, including prevalence, sequelae, diagnosis, and treatment. METHODS: Through chart reviews, we identified all male survivors of torture who had been treated for physical and/or psychological symptoms due to sexual trauma at the Boston Center for Refugee Health and Human Rights at Boston Medical Center between January 1, 2001 and January 1, 2002. Of the 72 men seen, 20 (28%) were survivors of sexual trauma...
January 2005: Urology
M Castañón García-Alix, R Carrasco Torrens, M E Muñoz Fernández, C Grande Moreillo, L Morales Fochs
Urethral stenosis is, after the fistula, the most frequent complication in patients undergoing hypospadias repair. Incidence ranges between 6% and 10% depending on the surgical technique. Treatment of this complication with simple dilation of the narrowed segment is enough in most cases. However, dilation of the stricture may be difficult in patients with severe hypospadias that required wide dissection and excision of fibrotic tissue to repair a large deviation and also in patients who had previously multiple operations...
April 2000: Actas Urologicas Españolas
S Uemura, J M Hutson, A A Woodward, J H Kelly, C W Chow
Three cases of urethral stricture due to balanitis xerotica obliterans (BXO) after hypospadias repair are reported. The first patient showed white, dense scarring on the prepuce before the hypospadias repair and developed a stricture of the urethra after the operation. The second and the third were uneventful for 6 and 2 years, respectively, after the hypospadias repair, and then developed urethral strictures. Pathologic diagnosis of the stenotic lesion is essential. Complete excision of the affected urethra with topical steroid ointment or sublesional triamcinolone injection is recommended for this condition...
2000: Pediatric Surgery International
R R Augspurger, J N Wettlaufer
We report 2 cases of Cushing's syndrome following intralesional triamcinolone acetonide injections of urethral strictures in children. The pharmacology of triamcinolone and its 2 parenteral forms, triamcinolone acetonide and triamcinolone diacetate, is discussed. For children we recommend the short-acting triamcinolone diacetate at 4-week intervals with dosage adjusted to age. In adults either type of triamcinolone may be used but triamcinolone acetonide should be given at 6-week intervals.
June 1980: Journal of Urology
H N Noe
The management of urethral strictures in children prior to urethroplasty has involved dilation and internal urethrotomy. Low success rates with these modalities led to the evaluation of visual urethrotomy and intralesional steroid injection. Of 12 patients so managed 10 achieved an excellent result, with 2 classified as having good results initially. These 2 cases were ultimately converted into the excellent category following repeat procedures. Non-invasive urinary flow rates proved invaluable in the management and assessment of these patients, and the success of their treatment...
May 1981: Journal of Urology
E Hradec, L Jarolim, R Petrik
Optical internal urethrotomy is a safe operative procedure for the management of a prevailing number of strictures of the male urethra. During the years 1976--1978, urethrotomy was carried out in 149 patients and the results are evaluated 1--3 years postoperatively. In the series of patients treated by urethrotomy without corticoid injection the rate of recurrent stricture was 19.4%. Using a specially constructed needle for injection of triamcinolone acetonide (Kenalog), we were able to reduce the recurrence rate to 4...
1981: European Urology
D M Mikat, H R Ackerman, K W Mikat
No abstract text is available yet for this article.
July 1973: Pediatrics
J R Sharpe, R P Finney
A review of steroid management of urethral strictures is presented. The 96 patients were followed for a year or more after urethral injection with triamcinolone. Intralesional steroid may be used in many types of strictures but it is especially useful in those cases with strictures in the distal urethra or the meatus, those occurring after radical prostatectomy and in some cases when 1 or more urethroplasties have been done. Every practicing urologist can benefit from using stricture injection in selected cases...
October 1976: Journal of Urology
C G Gaches, M H Ashken, M Dunn, J C Hammonds, I L Jenkins, P J Smith
The advent of selective internal urethrotomy under direct vision has enabled precision endoscopic surgery to be undertaken on a wide range of urethral strictures. A multi-centre survey of 197 cases involving 322 urethrotomy procedures from 5 urological departments in England is reported. The overall results after a follow-up of up to 4 years suggest that there is no indication for further procedures currently existing in 160 (81%) of those cases subjected to selective internal urethrotomy. The additional injection of triamcinalone acetate into the strictured area prior to urethrotomy is recommended in resistant cases...
December 1979: British Journal of Urology
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