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https://www.readbyqxmd.com/read/28534336/-establishment-of-pelvic-nerve-denervation-modal-in-mice
#1
Huiwen Shi, Yue Tian, Feixiang Dai, Lei Xiao, Zhigang Ke, Weidong Tong
OBJECTIVE: To establishment and verify pelvic nerve denervation (PND) model in mice. METHODS: (1) Establishment of models. Seventy-two healthy male SPE class C57 mice with age of 7 weeks and body weight of (25±1) g were chosen. These 72 mice were randomly divided into PND group containing 36 mice and sham operation group containing 36 mice. Referring to the establishment method of PND rats, after anesthesia, a laparotomy was performed on the mouse with an abdominal median incision...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28532275/protective-effects-of-vitamin-e-against-reproductive-toxicity-induced-by-di-2-ethylhexyl-phthalate-via-ppar-dependent-mechanisms
#2
Yangcai Wang, Bailin Chen, Tao Lin, Shengde Wu, Guanghui Wei
OBJECTIVE: To investigate the protective/ameliorative effects of vitamin E on di-2-(ethylhexyl) phthalate (DEHP)-induced reproductive toxicity, particularly in testicular toxicity in male rats, emphasizing peroxisome proliferator-activated receptor (PPAR) -Dependent mechanism. METHODS: Sprague-Dawley females were exposed by oral route to DEHP alone or associated with vitamin E from gestation day (GD) 12.5 to postnatal day (PND) 3 according to the following treatment regimens: vehicle control (corn oil), vitamin E (200 mg/kg) + corn oil, DEHP (500 mg/kg) + corn oil, and DEHP (500 mg/kg) + vitamin E (200 mg/kg) + corn oil...
May 22, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28527907/behavioral-and-cognitive-impact-of-early-life-stress-insights-from-an-animal-model
#3
Hesong Liu, Fatin Atrooz, Ankita Salvi, Samina Salim
BACKGROUND: Children subjected to traumatic events during childhood are reported to exhibit behavioral and cognitive deficits later in life, often leading to post-traumatic stress disorder (PTSD) and major depression. Interestingly, some children continue to remain normal despite being exposed to the same risk factors. These trauma-related behavioral and cognitive profiles across different stages of life are not well understood. Animal studies can offer useful insights. OBJECTIVE: The goal of this study was to determine the impact of early life exposure to traumatic events on behavioral and cognitive profile in rats by tracking the behavior of each rat at different ages...
May 17, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28526647/clipping-versus-coiling-in-anterior-circulation-ruptured-intracranial-aneurysms-a-meta-analysis
#4
REVIEW
George Fotakopoulos, Eleni Tsianaka, Kostas Fountas, Demosthenes Makris, Michael Spyrou, Juha Hernesniemi
BACKGROUND: The treatment plan with open surgical or endovascular repair in anterior circulation ruptured intracranial aneurysms must be taken on the basis of its special characteristics OBJECTIVE: To evaluate the possible superiority on outcomes, studying operative mortality (Op-Mo), permanent neurologic deficit (PND), late mortality (La-Mo) and need for re-intervention (re-iter), after open surgical and endovascular repair in anterior circulation ruptured intracranial aneurysms. METHODS: This Meta-Analysis included articles that compared outcomes of the two methods, published in full text form (last search performed on 06 December 2016)...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28523564/prenatal-and-early-postnatal-environmental-enrichment-reduce-acute-cell-death-and-prevent-neurodevelopment-and-memory-impairments-in-rats-submitted-to-neonatal-hypoxia-ischemia
#5
L E Durán-Carabali, D M Arcego, F K Odorcyk, L Reichert, J L Cordeiro, E F Sanches, L D Freitas, C Dalmaz, A Pagnussat, C A Netto
Environmental enrichment (EE) is an experimental strategy to attenuate the negative effects of different neurological conditions including neonatal hypoxia ischemia encephalopathy (HIE). The aim of the present study was to investigate the influence of prenatal and early postnatal EE in animals submitted to neonatal HIE model at postnatal day (PND) 3. Wistar rats were housed in EE or standard conditions (SC) during pregnancy and lactation periods. Pups of both sexes were assigned to one of four experimental groups, considering the early environmental conditions and the injury: SC-Sham, SC-HIE, EE-sham, and EE-HIE...
May 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28522409/neonatal-exposure-to-17%C3%AE-ethynyl-estradiol-ee-disrupts-follicle-development-and-reproductive-hormone-profiles-in-female-rats
#6
Haolin Zhang, Kazuyoshi Taya, Kentaro Nagaoka, Midori Yoshida, Gen Watanabe
Toxic effects induced by exposure to endocrine-disrupting chemicals during fetal and neonatal periods can be irreversible and exert effects throughout an animal's entire life. Our previous study showed that neonatal exposure to 17α-ethynyl estradiol (EE) induced irregular estrous cycle in adults. To uncover the reason for the delayed effect after neonatal exposure to EE, reproductive parameters including ovarian weight, ovarian steroidogenesis, and hormonal profiles were investigated in developing female rats...
May 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28514367/-the-new-possibilities-for-the-treatment-of-chronic-cough-associated-with-postnasal-drip
#7
A Yu Ovchinnikov, N A Miroshnichenko, A M Mityuk, V A Ryabinin, A G Gorban
Cough is considered to be one of the leading clinical symptoms associated with the pathological changes in the respiratory system. Notwithstanding a great variety of therapeutic pharmaceutical products possessed of the antitussive action, physicians tend the give preference to the preparations producing the combined effect. The present article reports the results of the clinical study designed to evaluate the effectiveness and safety of the application of rengalin exhibiting the combined antitussive, anti-inflammatory, and broncholytic action in the patients presenting with the postnasal drip syndrome...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28512781/developmental-regulation-and-localization-of-carnitine-palmitoyltransferases-cpts-in-rat-brain
#8
Jennifer N Jernberg, Caitlyn E Bowman, Michael J Wolfgang, Susanna Scafidi
While the brain's high energy demands are largely met by glucose, brain is also equipped with the ability to oxidize fatty acids for energy and metabolism. The brain expresses the carnitine palmitoyltransferases (CPTs) that mediate carnitine-dependent entry of long-chain acyl-CoAs into the mitochondrial matrix for β-oxidation - CPT1a and CPT2 located on the outer and inner mitochondrial membranes, respectively. Their developmental profile, regional distribution and activity as well as cell type expression remain unknown...
May 17, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28502417/analysis-of-bronchial-biopsies-in-chronic-cough
#9
Patricia Macedo, Qingling Zhang, Junpei Saito, Zhike Liang, Lorrette Ffolkes, Andrew G Nicholson, Kian Fan Chung
BACKGROUND: Chronic cough is commonly associated with asthma, gastro-oesophageal reflux disease and postnasal drip, but in a significant proportion, no associated cause can be found. We determined whether examination of bronchial biopsies would be useful in determining the cause associated with chronic cough. METHODS: 100 consecutive patients referred to a specialist cough clinic underwent a systematic assessment including a fiberoptic bronchoscopy for bronchial biopsies...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28501545/betamethasone-causes-intergenerational-reproductive-impairment-in-male-rats
#10
Cibele Dos Santos Borges, Taina Louise Pacheco, Katiussia Pinho da Silva, Fábio Henrique Fernandes, Mary Gregory, André Sampaio Pupo, Daisy Maria F Salvadori, Daniel G Cyr, Wilma De G Kempinas
Prenatal betamethasone (BM) exposure in rats negatively impacts sperm quality and male fertility. Studies have shown that BM can cause multi-generational effects on the pituitary-adrenal-axis of rats. The objective of this study was to assess the reproductive development and fertility of male rats (F2) whose fathers (F1) were exposed to BM (0.1mg/kg) on gestational days 12, 13, 18 and 19. In F2 rats, there was a significant reduction in body weights of the BM-treated group at PND 1 as well as delayed onset of puberty, and decreases in FSH levels, Leydig cell volume, sperm number and motility, seminal vesicle contractility and ejaculated volume...
May 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28497359/the-pattern-of-thalamocortical-and-brain-stem-projections-to-the-vibrissae-related-sensory-and-motor-cortices-in-de-whiskered-congenital-hypothyroid-rats
#11
Mohammad Reza Afarinesh, Gila Behzadi
The present study is designed to investigate the plastic organization of the thalamo-cortical (TC) and brain stem afferents of whisker primary sensory (wS1) and motor (wM1) cortical areas in congenital hypothyroid (CH) pups following whisker deprivation (WD) from neonatal to adolescence period. Maternal hypothyroidism was induced by adding propylthiouracil (PTU) to the drinking water from early embryonic day 16 to postnatal day (PND) 60. Pregnant rats were divided into intact and CH groups (n = 8). In each group, the total whiskers of pups (4 of 8) were trimmed continuously from PND 1 to PND 60...
May 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28487636/elamipretide-ss-31-ameliorates-isoflurane-induced-long-term-impairments-of-mitochondrial-morphogenesis-and-cognition-in-developing-rats
#12
Jing Wu, Shuangying Hao, Xiao-Ru Sun, Hui Zhang, Huihui Li, Hongting Zhao, Mu-Huo Ji, Jian-Jun Yang, Kuanyu Li
Mitochondria are supposed to be involved in the early pathogenesis of general anesthesia (GA)-induced neurotoxicity and long-term cognitive deficits in developing brains. However, effective pharmacologic agents targeted on mitochondria during GA exposure are lacking. This study explores the protective effects of mitochondrion-targeted antioxidant elamipretide (SS-31) on mitochondrial morphogenesis and cognition in developing rats exposed to isoflurane. Rat pups at postnatal day (PND) 7 were exposed to 1.5% isoflurane for 6 h following intraperitoneal administration of elamipretide or vehicle with 30 min interval...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28485289/comparative-assessment-of-monopolar-and-bipolar-radiofrequency-surgery-of-inferior-turbinate
#13
Hasan Emre Koçak, Bengül Altaş, Salih Aydın, Ümit Taşkın, Mehmet Faruk Oktay, Mustafa Suphi Elbistanlı, Ayşe Pelin Yiğider
OBJECTIVE: The aim of this study was to compare early outcomes of monopolar (MP) and bipolar (BP) radiofrequency (RF) treatment of inferior turbinate hypertrophy from the perspective of both the patient and the surgeon. STUDY DESIGN: Prospective, randomized, single-blind study. MATERIALS AND METHODS: Seventy-one patients with inferior turbinate hypertrophy resistant to medical treatment. BP RF was used in 36 patients and MP RF in 35 patients, respectively...
July 10, 2016: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28471544/neonatal-hypothyroidism-affects-testicular-glucose-homeostasis-through-increased-oxidative-stress-in-prepubertal-mice-effects-on-glut3-glut8-and-cx43
#14
D Sarkar, S K Singh
Thyroid hormones (THs) play an important role in maintaining the link between metabolism and reproduction and the altered THs status is associated with induction of oxidative stress in various organs like brain, heart, liver and testis. Further, reactive oxygen species play a pivotal role in regulation of glucose homeostasis in several organs, and glucose utilization by Leydig cells is essential for testosterone biosynthesis and thus is largely dependent on glucose transporter 8 (GLUT8). Glucose uptake by Sertoli cells is mediated through glucose transporter 3 (GLUT3) under the influence of THs to meet energy requirement of developing germ cells...
May 4, 2017: Andrology
https://www.readbyqxmd.com/read/28465083/cocaine-sensitization-in-adult-long-evans-rats-perinatally-exposed-to-polychlorinated-biphenyls
#15
Mellessa M Miller, Jenna L N Sprowles, Jason N Voeller, Abby E Meyer, Helen J K Sable
Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants known to adversely affect the nervous system and more specifically the dopamine system. Developmental PCB exposure in rats has been shown to produce alterations in dopaminergic signaling that persist into adulthood. The reinforcing properties of psychostimulants are typically modulated via the dopaminergic system, so this project used a behavioral sensitization paradigm to evaluate whether perinatal PCB exposure altered sensitization to the psychostimulant cocaine...
April 29, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28464876/prenatal-chlorpyrifos-leads-to-autism-like-deficits-in-c57bl6-j-mice
#16
Anat Lan, Michal Kalimian, Benjamin Amram, Ora Kofman
BACKGROUND: Children are at daily risk for exposure to organophosphate insecticides, of which the most common is chlorpyrifos (CPF). Exposure of pregnant women to CPF was linked to decreased birth weight, abnormal reflexes, reduction in IQ, as well as increased maternal reports of signs of pervasive developmental disorder. The aim of current study was to examine the long term effects of prenatal exposure to CPF in C57BL/6 J (B6) mice with specific focus on social and repetitive behavior...
May 2, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28464874/diagnostic-value-of-endoscopic-appearance-during-ductoscopy-in-patients-with-pathological-nipple-discharge
#17
Ye Han, Jianyi Li, Sijia Han, Shi Jia, Yang Zhang, Wenhai Zhang
BACKGROUND: To explore the features of ductoscopic appearance that may be diagnostic in patients with pathologic nipple discharge (PND) and to discuss the diagnostic criteria for intraductal tumors. METHODS: We reviewed 247 patients with PND but without a palpable mass who were evaluated using either surgical biopsy or excision. Data concerning patient age, duration of discharge, discharge color, and the details of endoscopic appearance were analyzed according to the pathological results...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28460650/developmental-toxicant-exposure-in-a-mouse-model-of-alzheimer-s-disease-induces-differential-sex-associated-microglial-activation-and-increased-susceptibility-to-amyloid-accumulation
#18
A N vonderEmbse, Q Hu, J C DeWitt
As the resident macrophage of the central nervous system, microglia are thought to contribute to Alzheimer's disease (AD) pathology through lack of neuroprotection. The role of immune dysfunction in AD may be due to disruption of regulatory signals for the activation of microglia that may occur early in development. We hypothesized that early toxicant exposure would systematically activate microglia, possibly reversing the pathological severity of AD. Offspring of a triple transgenic murine model for AD (3×TgAD) were exposed to a model neurotoxicant, lead acetate, from postnatal days (PND) 5-10...
May 2, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28459055/video-nasoendoscopic-assisted-transoral-adenoidectomy-with-the-peak-plasmablade-a-preliminary-report-of-a-case-series
#19
Chao-Yin Kuo, Yuan-Yung Lin, Hsin-Chien Chen, Cheng-Ping Shih, Chih-Hung Wang
Objectives. The primary objective for this study is to evaluate the advantages, disadvantages, surgical applicability, and outcome of the pulsed electron avalanche knife (PEAK) PlasmaBlade in transoral adenoidectomy under direct visualization using video nasoendoscopy. Patients and Methods. In this series, six cases of adenoid hypertrophy showing varying clinical presentations in relation to its clinical course were surgically treated using a PEAK PlasmaBlade. Before and after surgery, all patients underwent nasal endoscopy to define the grading of hypertrophic adenoids and postoperative outcome...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28458069/postnatal-development-and-behavior-effects-of-in-utero-exposure-of-rats-to-radiofrequency-waves-emitted-from-conventional-wifi-devices
#20
Haifa Othman, Mohamed Ammari, Kaïs Rtibi, Noura Bensaid, Mohsen Sakly, Hafedh Abdelmelek
The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2h a day throughout gestation period. Control females were subjected to the same conditions as treated group without applying WiFi radiations. After delivery, the offspring was tested for physical and neurodevelopment during its 17 postnatal days (PND), then for anxiety (PND 28) and motricity (PND 40-43), as well as for cerebral oxidative stress response and cholinesterase activity in brain and serum (PND 28 and 43)...
April 22, 2017: Environmental Toxicology and Pharmacology
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