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https://www.readbyqxmd.com/read/28819990/effects-of-maternal-high-fat-diet-and-sedentary-lifestyle-on-susceptibility-of-adult-offspring-to-ozone-exposure-in-rats
#1
C J Gordon, P M Phillips, A F M Johnstone, J Schmid, M C Schladweiler, A Ledbetter, S J Snow, U P Kodavanti
Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-day-old female Long-Evans rats were fed a control (CD) or high-fat (HF) (60% calories) diet for 6 wks and then bred. GD1 rats were then housed with a running wheel (RW) or without a wheel (SED) until parturition, creating four groups of offspring: CD-SED, CD-RW, HF-SED and HF-RW...
August 18, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28818871/sexual-dimorphism-of-the-pulmonary-transcriptome-in-neonatal-hyperoxic-lung-injury-identification-of-angiogenesis-as-a-key-pathway
#2
Cristian Coarfa, Yuhao Zhang, Suman Maity, Dimuthu Perera, Weiwu Jiang, Lihua Wang, Xanthi Couroucli, Bhagavatula Moorthy, Krithika Lingappan
Bronchopulmonary dysplasia (BPD) is characterized by impaired alveolar secondary septation and vascular growth. Exposure to high concentrations of oxygen (hyperoxia) contributes to the development of BPD. Male sex is considered an independent risk factor for the development of BPD. The reasons underlying sexually dimorphic outcomes in premature neonates are not known. We hypothesized that sex-specific modulation of biological processes in the lung under hyperoxic conditions, contributes to sex-based differences...
August 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28805606/detection-of-sea-type-%C3%AE-thalassemia-in-embryo-biopsies-by-digital-pcr
#3
Ta-Hsien Lee, Ya-Chiung Hsu, Chia Lin Chang
OBJECTIVE: Accurate and efficient pre-implantation genetic diagnosis (PGD) based on the analysis of single or oligo-cells is needed for timely identification of embryos that are affected by deleterious genetic traits in in vitro fertilization (IVF) clinics. Polymerase chain reaction (PCR) is the backbone of modern genetic diagnoses, and a spectrum of PCR-based techniques have been used to detect various thalassemia mutations in prenatal diagnosis (PND) and PGD. Among thalassemias, SEA-type α-thalassemia is the most common variety found in Asia, and can lead to Bart's hydrops fetalis and serious maternal complications...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28802914/forced-but-not-free-choice-nicotine-during-lactation-alters-maternal-behaviour-and-noradrenergic-system-of-pups-impact-on-social-behaviour-of-adolescent-isolated-male-rats
#4
Doriana Chirico, Emilia Romano, Marco Famele, Rosa Draisci, Rosanna Mancinelli, Tiziana Pascucci, Walter Adriani
Adverse effects of nicotine during pregnancy have been greatly studied, while nowadays few works are focused on consequences of maternal tobacco smoking after birth. The present study investigated the behavioural and early neurochemical effects of nicotine treatment during first weeks of post-natal life in rats. We used "free choice" treatment (H2O+NIC dams could drink from two bottles, containing 10mg/L nicotine hydrogen tartrate salt, or water) versus "forced choice" (NIC+NIC mothers could drink from two bottles both containing nicotine hydrogen tartrate salt, range from 0...
August 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28798887/attitude-toward-prenatal-testing-and-termination-of-pregnancy-among-health-professionals-and-medical-students-in-saudi-arabia
#5
Nagwa E A Gaboon, Khadijah H Bakur, Alaa Y Edrees, Jumana Y Al-Aama
This study was aimed at assessing the attitude of health care professionals in Jeddah city toward prenatal diagnosis (PND) and termination of pregnancy (TOP). A cross-sectional study was conducted, and the participants completed a self-administered questionnaire. Approximately 82% of participants showed a consistent trend of accepting PND when appropriate, and 47.5% of the respondents were in favor of TOP if the fetus had a severe disease. Compared with men (69.3%), a significantly greater number of women (88%) accepted to have PND...
September 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/28796629/hepatic-lipid-accumulation-and-nrf2-expression-following-perinatal-and-peripubertal-exposure-to-bisphenol-a-in-a-mouse-model-of-nonalcoholic-liver-disease
#6
Prajakta C Shimpi, Vijay R More, Maneesha Paranjpe, Ajay C Donepudi, Jaclyn M Goodrich, Dana C Dolinoy, Beverly Rubin, Angela L Slitt
BACKGROUND: Exposure to chemicals during critical windows of development may re-program liver for increased risk of nonalcoholic fatty liver disease (NAFLD). Bisphenol A (BPA), a plastics component, has been described to impart adverse effects during gestational and lactational exposure. Our work has pointed to nuclear factor E2-related factor 2 (Nrf2) being a modulator of hepatic lipid accumulation in models of NAFLD. OBJECTIVES: To determine if chemical exposure can prime liver for steatosis via modulation of NRF2 and epigenetic mechanisms...
August 4, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28782587/prolonged-ketamine-exposure-induces-increased-activity-of-the-glun2b-containing-n-methyl-d-aspartate-receptor-in-the-anterior-cingulate-cortex-of-neonatal-rats
#7
Saurabh S Kokane, Kerui Gong, Jianhui Jin, Qing Lin
Ketamine is a commonly used anesthetic among pediatric patients due to its high efficacy. However, it has been demonstrated by several preclinical studies that, widespread accelerated programmed death of neurons (neuroapoptosis) occurs due to prolonged or repeated exposure to ketamine specifically in the neonatal brain. Therefore, an emphasis on understanding the molecular mechanisms underlying this selective vulnerability of the neonatal brain to ketamine-induced neuroapoptosis becomes important in order to identify potential therapeutic targets, which would help prevent or at least ameliorate this neuroapoptosis...
August 4, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28780397/neonatal-exposure-to-a-glyphosate-based-herbicide-alters-uterine-decidualization-in-rats
#8
Paola I Ingaramo, Jorgelina Varayoud, María M Milesi, Marlise Guerrero Schimpf, Ramiro Alarcón, Mónica Muñoz-de-Toro, Enrique H Luque
We investigated whether defective modulation of uterine signaling may cause decidualization failure in rats neonatally exposed to a glyphosate-based herbicide (GBH). Female pups received vehicle or 2mg/kg of GBH from postnatal day (PND) 1 to PND7. On PND8 and PND21, Wnt5a and β-catenin expression was evaluated in uterine samples. On gestational day (GD) 9, Wnt5a, Wnt7a and β-catenin expression and Dkk1 and sFRP4 mRNA were evaluated on implantation sites. On PND8, GBH-exposed rats showed increased Wnt5a and β-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and β-catenin expression in subepithelial stroma but decreased β-catenin expression in glandular epithelium...
August 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28780256/perinatal-depression-adverse-life-events-and-hypothalamic-adrenal-pituitary-axis-response-to-cold-pressor-stress-in-latinas-an-exploratory-study
#9
Sandraluz Lara-Cinisomo, Karen M Grewen, Susan S Girdler, Jayme Wood, Samantha Meltzer-Brody
BACKGROUND: Latinas are disproportionately affected by perinatal depression (PND) as well as by adverse life events (ALEs), an independent predictor of PND. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been seen both in women with PND and with a history of ALEs in non-Latinas. Although some evidence suggests that HPA axis dysregulation may mediate the link between ALEs and PND, this hypothesis has received little attention and there are no studies that have examined these pathways in Latinas...
August 2, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28769031/sex-specific-placental-accumulation-and-behavioral-effects-of-developmental-firemaster-550-exposure-in-wistar-rats
#10
Kylie R Baldwin, Allison L Phillips, Brian Horman, Sheryl E Arambula, Meghan E Rebuli, Heather M Stapleton, Heather B Patisaul
Firemaster® 550 (FM 550) is a commercial flame retardant mixture of brominated and organophosphate compounds applied to polyurethane foam used in furniture and baby products. Due to widespread human exposure, and structural similarities with known endocrine disruptors, concerns have been raised regarding possible toxicity. We previously reported evidence of sex specific behavioral effects in rats resulting from developmental exposure. The present study expands upon this prior finding by testing for a greater range of behavioral effects, and measuring the accumulation of FM 550 compounds in placental tissue...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762667/reproductive-and-neurobehavioral-effects-of-ethiprole-administered-to-mice-in-the-diet
#11
Toyohito Tanaka, Akiko Inomata
BACKGROUND: Few studies were found for neurobehavioral toxicity of the phenylpyrazole insecticide ethiprole in mammals. This study was designed to evaluate the reproductive and neurobehavioral effects of ethiprole exposure in mice. METHODS: Ethiprole was given in the diet to provide levels of 0 (control), 0.0003, 0.0009, and 0.0027% from 5 weeks of age of the F0 generation to 11 weeks of age of the F1 generation in mice. Selected reproductive and neurobehavioral parameters were measured...
August 1, 2017: Birth defects research
https://www.readbyqxmd.com/read/28761500/predicting-factors-of-depression-antidepressant-use-and-positive-response-to-antidepressants-in-perinatal-and-postpartum-women
#12
Huyen Vu, Fadia T Shaya
BACKGROUND: In the United States, there is a disparity in knowledge of nationwide depression prevalence, the antidepressant use and the antidepressant responses during perinatal/postpartum periods. OBJECTIVE: This study investigated the predicting factors of depression, antidepressant use and positive antidepressant response during the perinatal/postpartum periods. METHOD: The 2007-2012 National Health and Nutrition Examination Surveys (NHANES) were combined to identify adult pregnant women, those within the 18-month postpartum period (n=492) and their depression statuses via demographics, health care accessibility, antidepressant use and illicit drug use information...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/28760465/elective-aortic-arch-repair-factors-influencing-neurologic-outcome-in-791-patients
#13
Mariano Cefarelli, Giacomo Murana, Giuseppina G Surace, Sebastiano Castrovinci, Giuliano Jafrancesco, Johannes Christiaan Kelder, Patrick Klein, Uday Sonker, Wim J Morshuis, Robin H Heijmen
BACKGROUND: The aim of this study was to determine perioperative factors influencing neurologic outcome in a single-center cohort of patients undergoing elective aortic arch operations. METHODS: From January 2005 to June 2015, 791 consecutive patients received open aortic arch operations with either antegrade selective cerebral perfusion (ASCP) (636 patients [80.4%]) or deep hypothermic circulatory arrest (DHCA) (155 patients [19.6%]). Main indications were degenerative aneurysm (85%) and chronic postdissection aneurysm (9...
July 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28754700/segregation-of-mitochondrial-dna-mutations-in-the-human-placenta-implication-for-prenatal-diagnosis-of-mtdna-disorders
#14
Pauline Vachin, Elodie Adda-Herzog, Gihad Chalouhi, Caroline Elie, Marlène Rio, Sophie Rondeau, Nadine Gigarel, Fabienne Jabot Hanin, Sophie Monnot, Roxana Borghese, Joana Bengoa, Yves Ville, Agnes Rotig, Arnold Munnich, Jean-Paul Bonnefont, Julie Steffann
BACKGROUND: Mitochondrial DNA (mtDNA) disorders have a high clinical variability, mainly explained by variation of the mutant load across tissues. The high recurrence risk of these serious diseases commonly results in requests from at-risk couples for prenatal diagnosis (PND), based on determination of the mutant load on a chorionic villous sample (CVS). Such procedures are hampered by the lack of data regarding mtDNA segregation in the placenta.The objectives of this report were to determine whether mutant loads (1) are homogeneously distributed across the whole placentas, (2) correlate with those in amniocytes and cord blood cells and (3) correlate with the mtDNA copy number...
July 28, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28751239/experiencing-early-life-maternal-separation-increases-pain-sensitivity-in-adult-offspring
#15
Fabiana Cardoso Vilela, Jádina Santos Vieira, Alexandre Giusti-Paiva, Marcelo Lourenço da Silva
Maternal separation is a widely accepted model for studying long-term behavioral changes produced by events during early life and its association with changes in pain sensitivity. Thus, our objective was to evaluate sensitivity to pain, under different stimuli in adult male and female rats that had undergone early life maternal separation. Animals were subjected to maternal separation from postnatal day (PND) 2-15. Maternal behavior and litter weight were evaluated during this period. Sensitivity to pain was assessed in offsprings during adulthood by exposing them to stimuli, including formalin (5%; 20μl), a hot plate, and the electronic von Frey test, 4, 7, 10, and 24h after the administration of saline or Freund's complete adjuvant (CFA) injection...
July 25, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28747485/developmental-vitamin-d-deficiency-affects-spatial-learning-in-wistar-rats
#16
Anwar N Al-Harbi, Khalid M Khan, Abdur Rahman
Background: Vitamin D deficiency is a global problem. Recent evidence suggests that vitamin D is involved in brain development and function. Vitamin D deficiency has been associated with poor cognitive function in adults, but the effect of developmental vitamin D deficiency (DVDD) on cognitive function and brain development in children has not been well established.Objective: We explored the effects of DVDD on cognitive functions and brain morphology of rat pups.Methods: Wistar rat pups born to control and vitamin D-deficient dams were divided into 4 groups: control (C), deficient during gestation (dG), deficient during lactation (dL), and deficient during gestation and lactation (dGL)...
July 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28743513/chronic-exposure-to-the-fungicide-propiconazole-behavioral-and-reproductive-evaluation-of-f1-and-f2-generations-of-male-rats
#17
Milene Leivas Vieira, Nathália Orlandini Costa, Marina Rangel F Pereira, Suzana de Fátima Paccola Mesquita, Estefânia Gastaldello Moreira, Daniela Cristina Ceccatto Gerardin
Several studies have suggested that propiconazole (PROP) may be an endocrine disruptor; possibly altering the activity of the CYP51 enzyme, which is part of the cholesterol biosynthesis pathway required for the production of sexual steroid hormones. Another PROP effect is inhibition of the aromatase enzyme that converts androgens into estrogens, which could lead to negative effects on reproductive parameters. Therefore, the present study evaluated the reproductive and developmental toxicity of PROP by exposing two generations (F1 and F2) of male rats to this fungicide, since a previous study from our lab reported that PROP has anti-estrogenic and anti-androgenic activities (Costa et al...
July 22, 2017: Toxicology
https://www.readbyqxmd.com/read/28742930/information-about-first-trimester-screening-and-self-reported-distress-among-pregnant-women-and-partners-comparing-two-methods-of-information-giving-in-sweden
#18
Peter Lindgren, Magdalena Stadin, Inger Blomberg, Karin Nordin, Hanna Sahlgren, Charlotta Ingvoldstad Malmgren
INTRODUCTION: Balanced information prior to prenatal diagnosis (PND) aims to help expectant parents to make an informed choice. However, it is important that the information does not increase the expectant parents' psychological distress. The aim was to examine psychological distress among expectant parents, before and after receiving information about PND, to evaluate the possible differences between two different procedures of information giving, and to evaluate the association between satisfaction with the information and psychological distress...
July 25, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28738878/tlr4-response-mediates-ethanol-induced-neurodevelopment-alterations-in-a-model-of-fetal-alcohol-spectrum-disorders
#19
María Pascual, Jorge Montesinos, Sandra Montagud-Romero, Jerónimo Forteza, Marta Rodríguez-Arias, José Miñarro, Consuelo Guerri
BACKGROUND: Inflammation during brain development participates in the pathogenesis of early brain injury and cognitive dysfunctions. Prenatal ethanol exposure affects the developing brain and causes neural impairment, cognitive and behavioral effects, collectively known as fetal alcohol spectrum disorders (FASD). Our previous studies demonstrate that ethanol activates the innate immune response and TLR4 receptor and causes neuroinflammation, brain damage, and cognitive defects in the developmental brain stage of adolescents...
July 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28734801/sex-specific-differences-in-the-modulation-of-growth-differentiation-factor-15-gdf15-by-hyperoxia-in-vivo-and-in-vitro-role-of-hif-1%C3%AE
#20
Yuhao Zhang, Weiwu Jiang, Lihua Wang, Krithika Lingappan
Male premature neonates are more susceptible than females to the development of bronchopulmonary dysplasia (BPD). The reasons underlying sexually dimorphic outcomes in premature neonates are not known. GDF15 (Growth and differentiation factor 15) is a secreted cytokine and plays a role in cell proliferation, apoptosis, and angiogenesis. In this study, we sought to elucidate the sex-specific expression of Gdf15 in the lung in vivo in neonatal hyperoxic lung injury and its regulation by Hif-1α, and to delineate the differences in GDF15 expression in male and female human umbilical venous endothelial cells in an in vitro model of oxygen toxicity...
July 20, 2017: Toxicology and Applied Pharmacology
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