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https://www.readbyqxmd.com/read/28728135/prostate-cancer-risk-and-dna-methylation-signatures-in-aging-rats-following-developmental-bpa-exposure-a-dose-response-analysis
#1
Gail S Prins, Shu-Hua Ye, Lynn Birch, Xiang Zhang, Ana Cheong, Han Lin, Esther Calderon-Gierszal, Jacob Groen, Wen-Yang Hu, Shuk-Mei Ho, Richard B van Breemen
BACKGROUND: Previous studies have uncovered heightened prostatic susceptibility to hormone-induced neoplasia from early-life exposure to low-dose bisphenol A (BPA). However, significant data gaps remain that are essential to address for biological relevance and necessary risk assessment. OBJECTIVES: A complete BPA dose-response analysis of prostate lesions across multiple prostatic lobes was conducted that included internal BPA dosimetry, progression to adenocarcinoma with aging and mechanistic connections to epigenetically reprogramed genes...
July 11, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28727004/physiology-and-endocrinology-symposium-postnatal-reproductive-development-and-the-lactocrine-hypothesis
#2
F F Bartol, A A Wiley, A F George, D J Miller, C A Bagnell
Maternal effects on development can program cell fate and dictate offspring phenotype. Such effects do not end at birth, but extend into postnatal life through signals communicated from mother to offspring in first milk (colostrum). Transmission of bioactive factors from mother to offspring as a specific consequence of nursing defines a lactocrine mechanism. The female reproductive tract is not fully formed at birth (postnatal day = PND 0). Data for ungulates and mice indicate that disruption of development during neonatal life can have lasting effects on the form and function of uterine tissues...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28724490/murine-astrovirus-infection-and-transmission-in-neonatal-cd1-mice
#3
Susan R Compton, Carmen J Booth, James D Macy
Murine astrovirus (MuAstV) is a recently identified, widespread infection among laboratory mice. Our goal was to determine the duration of MuAstV infection, susceptibility of pups, and efficacy of soiled-bedding sentinels and environmental monitoring. Eight CD1 dams and their litters of 3-d-old pups and 8 CD1 dams and their litters of 13-d-old mice were inoculated orally with MuAstV. Neither dams nor offspring demonstrated any clinical signs, and MuAstV had little to no effect on weight gain in pups. MuAstV RNA was detected in feces from 15 of the 16 dams through postnatal day (PND) 21, and 9 dams were still shedding MuAstV at PND 42...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28716176/systematic-review-of-patient-reported-outcomes-after-revision-endoscopic-sinus-surgery
#4
Shashi Prasad, Eric Fong, Eng H Ooi
BACKGROUND: Revision endoscopic sinus surgery (RESS) may be required for partially controlled or uncontrolled chronic rhinosinusitis. Studies that reported technical success, e.g., sinus ostia patency after RESS, do not address whether the patient's symptoms and quality of life (QOL) improve after surgery. However, patient-reported outcome measures (PROM) are useful to assess the impact of sinus surgery on a patient's symptoms and QOL. OBJECTIVE: This systematic review was undertaken to evaluate the impact of RESS on PROMs...
July 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28709042/perinatal-exposure-of-pregnant-rats-to-cypermethrin-delays-testicular-descent-impairs-fertility-in-f1-male-progeny-leading-to-developmental-defects-in-f2-generation
#5
Dipty Singh, Sharad Bhagat, Paula Raijiwala, Vikas Dighe, Geeta Vanage
Cypermethrin (CYP) is a widely used synthetic pyrethroid insecticide and regarded as a potential endocrine disruptor. CYP exposure may pose a great risk to human health including adverse effect on their reproductive functions. This study aimed to delineate the effects of perinatal exposure of rats to CYP on the sexual maturation and fertility of F1 male progeny. Pregnant rats (F0) were gavaged daily with CYP (0, 1, 10, 25 mg/kg BW/day) and Diethylestilbestrol (DES, 10 μg/kg BW/day), as positive control from gestation day 6 to postnatal day 21...
July 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28705472/adolescent-social-isolation-affects-schizophrenia-like-behavior-and-astrocyte-biomarkers-in-the-pfc-of-adult-rats
#6
Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao, Weiwen Wang
Social isolation is regarded as a cause of schizophrenia spectrum disorders. Animal models of schizophrenia are constructed by repeated early environment deprivation as an important paradigm to reveal its pathological mechanism. Male Sprague Dawley rats were assigned to either social-rearing (SR) or isolated-rearing (IR) groups during postnatal days (PNDs) 21-34. On PND 56, all rats underwent behavioral testing including locomotor activity, anxiety-related behaviors in an open field and prepulse inhibition (PPI)...
July 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28705171/formula-diet-driven-microbiota-shifts-tryptophan-metabolism-from-serotonin-to-tryptamine-in-neonatal-porcine-colon%C3%AF
#7
Manish Kumar Saraf, Brian D Piccolo, Anne K Bowlin, Kelly E Mercer, Tanya LeRoith, Sree V Chintapalli, Kartik Shankar, Thomas M Badger, Laxmi Yeruva
BACKGROUND: The gut microbiota of breast-fed and formula-fed infants differ significantly, as do the risks for allergies, gut dysfunction, and upper respiratory tract infections. The connections between breast milk, various formulas, and the profiles of gut bacteria to these childhood illnesses, as well as the mechanisms underlying the effects, are not well understood. METHODS: We investigated distal colon microbiota by 16S RNA amplicon sequencing, morphology by histomorphometry, immune response by cytokine expression, and tryptophan metabolism in a pig model in which piglets were sow-fed, or fed soy or dairy milk-based formula from postnatal day (PND) 2 to 21...
July 14, 2017: Microbiome
https://www.readbyqxmd.com/read/28702773/can-exercise-or-physical-activity-help-improve-postnatal-depression-and-weight-loss-a-systematic-review
#8
REVIEW
Maryam Saligheh, Daniel Hackett, Philip Boyce, Stephen Cobley
Despite exercise or physical activity (PA) being effective on depression and weight management generally, its effectiveness remains uncertain during postpartum. This systematic review aimed to determine the efficacy of exercise or PA interventions on postnatal depression (PND) and weight loss, with a subsequent aim to identify more effective intervention approaches. Using PRISMA guidelines, data searches conducted across six databases. Nine studies fulfilled our inclusion criteria. Based on identified studies (some with high-quality RCT designs), there was inconsistency as to whether exercise or PA simultaneously reduced PND symptoms and assisted weight loss (or related body composition indices)...
July 12, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28696058/early-postnatal-gentamicin-and-ceftazidime-treatment-in-normal-and-food-restricted-neonatal-wistar-rats-implications-for-kidney-development
#9
Ruud R G Bueters, Annelies Jeronimus-Klaasen, Roger J M Brüggemann, Lambertus P van den Heuvel, Michiel F Schreuder
BACKGROUND: Up to two-thirds of premature born neonates are treated for infections with aminoglycosides such as gentamicin. Although acute toxicities are well described, there is uncertainty on developmental changes after treatment of premature born neonates. We studied the effect of gentamicin and ceftazidime on kidney development in the rat. Additionally, we evaluated the modulating effect of extrauterine growth restriction. METHODS: On postnatal day (PND) 2, Wistar rats were cross-fostered into normal sized litters (12 pups) or large litters (20 pups) to create normal food (NF) or food restricted (FR) litters to simulate growth restriction and dosed daily intraperitoneally with placebo, 4 mg/kg of gentamicin or 50 mg/kg ceftazidime until PND 8...
July 11, 2017: Birth defects research
https://www.readbyqxmd.com/read/28688903/differential-effects-between-developmental-and-postpubertal-exposure-to-n-methyl-n-nitrosourea-on-progenitor-cell-proliferation-of-rat-hippocampal-neurogenesis-in-relation-to-cox2-expression-in-granule-cells
#10
Yousuke Watanabe, Kota Nakajima, Sayaka Mizukami, Yumi Akahori, Nobuya Imatanaka, Gye-Hyeong Woo, Toshinori Yoshida, Makoto Shibutani
This study was performed to compare the exposure effects of N-methyl-N-nitrosourea (MNU), a cytocidal agent of proliferating cells, on rat hippocampal neurogenesis between developmental and postpubertal periods. Developmental exposure through maternal drinking water from gestational day 6 to day 21 after delivery on weaning decreased GFAP-immunoreactive ((+)) stem cells and increased immunoreactive cells indicative of subsequent progenitor and postmitotic immature neuronal populations, TUNEL(+) or p21(Cip1/Waf1+) stem/progenitor cells and COX2(+) granule cells, on postnatal day (PND) 21...
July 5, 2017: Toxicology
https://www.readbyqxmd.com/read/28686282/early-maternal-separation-induces-preference-for-sucrose-and-aspartame-associated-with-increased-blood-glucose-and-hyperactivity
#11
L Aya-Ramos, C Contreras-Vargas, J L Rico, Z Dueñas
Early life stress and exposure to sweeteners lead to physiological and behavioral alterations in adulthood. Nevertheless, many genetic and environmental factors as well as the neurobiological mechanisms that contribute to the development of these disorders are not fully understood. Similarly, evidence about the long-term metabolic effects of exposure to sweeteners in early life is limited and inconsistent. This study used an animal model of maternal separation during breastfeeding (MS) to analyze the effects of early life stress on consumption of sweeteners, weight gain, blood glucose and locomotion...
July 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28676969/genetic-study-of-the-pah-locus-in-the-iranian-population-familial-gene-mutations-and-minihaplotypes
#12
Masoumeh Razipour, Elaheh Alavinejad, Seyede Zahra Sajedi, Saeed Talebi, Mona Entezam, Neda Mohajer, Golnaz-Ensieh Kazemi-Sefat, Jalal Gharesouran, Aria Setoodeh, Seyyed Mojtaba Mohaddes Ardebili, Mohammad Keramatipour
Phenylketonuria (PKU), one of the most common inborn errors of amino acid metabolism, is caused by mutations in the phenylalanine hydroxylase (PAH) gene (PAH). PKU has wide allelic heterogeneity, and over 600 different disease-causing mutations in PAH have been detected to date. Up to now, there have been no reports on the minihaplotype (VNTR/STR) analysis of PAH locus in the Iranian population. The aims of the present study were to determine PAH mutations and minihaplotypes in Iranian families with PAH deficiency and to investigate the correlation between them...
July 4, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28676390/effects-of-bisphenol-a-analogues-on-reproductive-functions-in-mice
#13
Mingxin Shi, Nikola Sekulovski, James A MacLean, Kanako Hayashi
This study was performed to examine whether bisphenol (BP) A analogues, BPE and BPS, negatively impacts reproductive functions using mice as a model. CD-1 mice were exposed to control treatment (corn oil), BPA, BPE and BPS (50μg/kg or 10mg/kg) from birth to postnatal day (PND) 60 by s.c. injection every three days. Sperm counts or motility was significantly reduced by BPA, BPE or BPS exposure on PND 60 or PND 90. Exposure of BPA, BPE and BPS disrupted the progression of germ cell development, as morphometric analyses exhibited an abnormal distribution of the stages of spermatogenesis...
July 1, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28675061/postnatal-depression-maternal-infant-bonding-and-social-support-a-cross-cultural-comparison-of-nigerian-and-british-mothers
#14
Oladayo Afolabi, Louise Bunce, Joanne Lusher, Samantha Banbury
OBJECTIVES: The high prevalence of Post-Natal Depression (PND) in low and lower-middle income countries of Africa raises questions about the functionality of the abundant informal support accessed in the enmeshed family structure. This study examined the interaction between social support, parity and culture in the development of PND and maternal-infant bonding (MIB) among Nigerian, British and Nigerian Immigrant mothers in the UK. METHODS: Participants (N = 124) were recruited from the UK and Nigeria via local support groups for mothers, websites offering motherhood-related content and social media...
July 4, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28674770/choosing-between-higher-and-lower-resolution-microarrays-do-pregnant-women-have-sufficient-knowledge-to-make-informed-choices-consistent-with-their-attitude
#15
S L van der Steen, E M Bunnik, M G Polak, K E M Diderich, J Verhagen-Visser, L C P Govaerts, M Joosten, M F C M Knapen, A T J I Go, D Van Opstal, M I Srebniak, R J H Galjaard, A Tibben, S R Riedijk
Developments in prenatal testing allow the detection of more findings. SNP arrays in prenatal diagnosis (PND) can be analyzed at 0.5 Mb resolution detecting more clinically relevant anomalies, or at 5 Mb resolution. We investigated whether women had sufficient knowledge to make informed choices regarding the scope of their prenatal test that were consistent with their attitude. Pregnant women could choose between testing at 5 or at 0.5 Mb array. Consenting women (N = 69) received pre-test genetic counseling by phone and filled out the Measure of Informed Choice questionnaire designed for this study...
July 4, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28667160/early-postnatal-secondhand-smoke-exposure-disrupts-bacterial-clearance-and-abolishes-immune-responses-in-muco-obstructive-lung-disease
#16
Brandon W Lewis, Razia Sultana, Rahul Sharma, Alexandra Noël, Ingeborg Langohr, Sonika Patial, Arthur L Penn, Yogesh Saini
Secondhand smoke (SHS) exposure has been linked to the worsening of ongoing lung diseases. However, whether SHS exposure affects the manifestation and natural history of imminent pediatric muco-obstructive airway diseases such as cystic fibrosis remains unclear. To address these questions, we exposed Scnn1b transgenic (Scnn1b-Tg(+)) mice to SHS from postnatal day (PND) 3-21 and lung phenotypes were examined at PND22. Although a majority of filtered air (FA)-exposed Scnn1b-Tg(+) (FA-Tg(+)) mice successfully cleared spontaneous bacterial infections by PND22, the SHS-exposed Scnn1b-Tg(+) (SHS-Tg(+)) mice failed to resolve these infections...
June 30, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28665129/topochemical-reduction-of-ymno3-into-a-composite-structure
#17
Houria Kabbour, Gilles H Gauthier, Franck Tessier, Marielle Huvé, Tanguy Pussacq, Pascal Roussel, Michael A Hayward, Zulma L Moreno B, Maya Marinova, Marie Colmont, Silviu Colis, Olivier Mentré
Topochemical modification methods for solids have shown great potential in generating metastable structures inaccessible through classical synthetic routes. Here, we present the enhanced topotactic reduction of the multiferroic compound YMnO3. At moderate temperature in ammonia flow, the most reduced YMnO3-δ (δ = 0.5) phase could be stabilized. XRD, PND, and HREM results show that phase separation occurs into two intimately intergrown layered sublattices with nominal compositions ∞[YMn(2+)O2+x]((1-2x)+) and ∞[YMn(2+)O3-x]((1-2x)-) containing versatile Mn(2+) coordinations...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28659827/increased-postnatal-cardiac-hyperplasia-precedes-cardiomyocyte-hypertrophy-in-a-model-of-hypertrophic-cardiomyopathy
#18
Emily T Farrell, Adrian C Grimes, Willem J de Lange, Annie E Armstrong, J Carter Ralphe
Rationale: Hypertrophic cardiomyopathy (HCM) occurs in ~0.5% of the population and is a leading cause of sudden cardiac death (SCD) in young adults. Cardiomyocyte hypertrophy has been the accepted mechanism for cardiac enlargement in HCM, but the early signaling responsible for initiating hypertrophy is poorly understood. Mutations in cardiac myosin binding protein C (MYBPC3) are among the most common HCM-causing mutations. Ablation of Mybpc3 in an HCM mouse model (cMyBP-C(-/-)) rapidly leads to cardiomegaly by postnatal day (PND) 9, though hearts are indistinguishable from wild-type (WT) at birth...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28657538/effects-of-low-dose-developmental-bisphenol-a-exposure-on-metabolic-parameters-and-gene-expression-in-male-and-female-fischer-344-rat-offspring
#19
Margareta H Lejonklou, Linda Dunder, Emelie Bladin, Vendela Pettersson, Monika Rönn, Lars Lind, Tomas B Waldén, P Monica Lind
BACKGROUND: Bisphenol A (BPA) is an endocrine-disrupting chemical that may contribute to development of obesity and metabolic disorders. Humans are constantly exposed to low concentrations of BPA, and studies support that the developmental period is particularly sensitive. OBJECTIVES: The aim was to investigate the effects of low-dose developmental BPA exposure on metabolic parameters in male and female Fischer 344 (F344) rat offspring. METHODS: Pregnant F344 rats were exposed to BPA via their drinking water, corresponding to (BPA0...
June 28, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28641987/food-deprivation-in-f0-generation-and-hypercaloric-diet-in-f1-generation-reduce-f2-generation-astrogliosis-in-several-brain-areas-after-immune-challenge
#20
T B Ogassawara, A Joaquim, C P Coelho, M M Bernardi, E Teodorov, M F M Martins, T B Kirsten, L V Bonamin, P D Dossa, L B Viebig, E F Bondan
AIMS: The effects of maternal food restriction during gestation in F0 generation followed by hypercaloric diet (HD) during puberty in F1 generation (F1HD) were investigated on astrocyte behavior of F2 generation. Also, the astrocyte behavior, after an immune challenge, was examined by the immunohistochemical expression of glial fibrillary acidic protein (GFAP) in several brain areas. METHODS: The body weight gain (BW) during development and in postnatal day (PND) 90-95, the retroperitoneal fat weight (RPF), and the size of larger and smaller adipocytes in the F1 generation were assessed to observe the effects of HD in female rats...
June 19, 2017: International Journal of Developmental Neuroscience
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