keyword
https://read.qxmd.com/read/38533178/genotoxicity-and-cytotoxicity-of-antineoplastic-drugs-at-environmentally-relevant-concentrations-after-long-term-exposure
#1
JOURNAL ARTICLE
P da Cunha de Medeiros, E A Nunes, G R M Barcelos, J E Perobelli
INTRODUCTION: 5-fluorouracil (5-FU) and methotrexate (MTX) are the antineoplastic drugs most commonly used worldwide. Considered cytotoxic, these pharmaceuticals exhibit low specificity, causing damage not only to cancer cells but also to healthy cells in organisms. After being consumed and metabolized, these drugs are excreted through urine and feces, followed by wastewater treatment. However, conventional treatments do not have the capacity to completely remove these substances, risking their introduction into freshwater systems...
April 2024: Toxicology Research
https://read.qxmd.com/read/38532432/implementing-and-evaluating-group-interpersonal-therapy-for-postnatal-depression-in-lebanon-and-kenya-individually-randomised-superiority-trial
#2
JOURNAL ARTICLE
Peter Fonagy, Rabih El Chammay, Carol Ngunu, Manasi Kumar, Lena Verdeli, Elizabeth Allison, Ghida Anani, Pasco Fearon, Fouad Fouad, Zoe Hoare, Lucina Koyio, Henrietta Moore, Andrew Nyandigisi, Stephen Pilling, Hannah Sender, Jolene Skordis, Rachel Evans, Gerard Joseph Abou Jaoude, Beatrice Madeghe, Sandra Pardi Arsen Maradian, Ciara O'Donnell, Elizabeth Simes, Alexandra Truscott, Grace Nduku Wambua, Obadia Yator
BACKGROUND: Depression ranks as the foremost mental health concern among childbearing women. Within low- and middle-income countries (LMICs), between 20 and 25% of women encounter depression during pregnancy or soon after delivery. This condition impacts not only the mothers but also their offspring. Offspring of women suffering from postnatal depression (PND) exhibit suboptimal cognitive development and increased emotional and behavioural issues throughout their growth. This scenario becomes more pronounced in LMICs, where numerous adversities further jeopardise children's developmental progress...
March 26, 2024: Trials
https://read.qxmd.com/read/38527875/tetrabromobisphenol-a-exerts-thyroid-disrupting-effects-but-has-little-overt-impact-on-postnatal-brain-development-and-neurobehaviors-in-mice
#3
JOURNAL ARTICLE
Shilin Song, Yuanyuan Li, Lin Lv, Mengqi Dong, Zhanfen Qin
Tetrabromobisphenol A (TBBPA) is a widely used brominated flame retardant. There is evidence showing that TBBPA can exert thyroid disrupting effects in mammals, but different results were also reported, along with inconsistent reports regarding its neurotoxicity. Here, we investigated thyroid disrupting effects and neurotoxicity of TBBPA (5, 50, 500 µg/(kg·day)) to male mice following maternal and direct exposure through drinking water, with the anti-thyroid drug propylthiouracil (PTU) as the positive control...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38524952/maternal-and-neonatal-risk-factors-associated-with-perinatal-depression-a-prospective-cohort-study
#4
JOURNAL ARTICLE
Bharathi Rajendran, Syed Ummar Ibrahim, Sureshkumar Ramasamy
BACKGROUND: Perinatal depression (PND) is often under-treated and under-recognized. It has a negative impact on infant development and mother-child interactions. This study aims to estimate the prevalence of PND during pregnancy and in the postpartum period and the effect of sociodemographic factors, psychosocial stressors, and obstetric and neonatal factors on PND. METHODS: 166 antenatal mothers attending tertiary center, who completed the 1st-trimester, were evaluated on baseline sociodemographic, psychosocial, obstetric, neonatal, and post neonatal factors by using a semi-structured questionnaire...
January 2024: Indian Journal of Psychological Medicine
https://read.qxmd.com/read/38521883/real-world-effectiveness-of-high-dose-tafamidis-on-neurologic-disease-progression-in-mixed-phenotype-variant-transthyretin-amyloid-cardiomyopathy
#5
JOURNAL ARTICLE
Nicholas Streicher, Leslie Amass, Rong Wang, Jennifer M Stephens, Traci LeMasters, Rutika Raina, Emma Merrill, Farooq H Sheikh
INTRODUCTION: Transthyretin amyloidosis (ATTR) is a progressive, heterogeneous rare disease manifesting as ATTR polyneuropathy (ATTR-PN), ATTR cardiomyopathy (ATTR-CM), or a mixed phenotype. Tafamidis meglumine (20 mg po qd) is approved in some markets to delay neurologic progression in ATTR-PN, while high-dose tafamidis (80/61 mg po qd) is approved worldwide to reduce cardiovascular mortality and cardiovascular-related hospitalization in ATTR-CM. The objective of this study was to assess the real-world benefit of high-dose tafamidis for delaying neurologic progression in patients with mixed-phenotype variant ATTR-CM (ATTRv-CM)...
March 23, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38505075/cerebral-protection-in-acute-type-a-aortic-dissection-surgery-a-systematic-review-and-meta-analysis
#6
JOURNAL ARTICLE
Mehran Rahimi, Hadi Sahrai, Ali Norouzi, Mohammadreza Taban-Sadeghi, Ahmadali Khalili, Sina Hamzehzadeh, Reza Ali Akbari Khoei, Hossein Hosseinifard, Ralf Martz Sulague, Jacques Kpodonu
BACKGROUND: Acute type A aortic dissection (ATAAD) still challenges physicians and warrants emergent surgical management. Two main methods to reduce cerebrovascular events in ATAAD surgeries are antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP). We conducted a systematic review and meta-analysis to compare the outcomes of ACP and RCP methods during the ATAAD surgery. METHODS: In this study, we searched the databases until March 29th , 2023...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38500346/-epicatechin-treatment-did-not-modify-the-thermogenic-pathway-in-the-gastrocnemius-muscle-of-male-rat-offspring-obeses-by-programming
#7
JOURNAL ARTICLE
María Elena Tejeda, Sergio De Los Santos, Ramón Mauricio Coral-Vázquez, Ana Álvarez-Chávez, Carlos Palma Flores, Elena Zambrano, Juan Pablo Méndez, Patricia Canto
The aim of this study was to analyse the expression of genes related to the regulation of energy metabolism in skeletal muscle tissue by comparing male offspring in two age groups [at 110 and 245 postnatal days (pnd)] from a mother with obesity induced by a high-fat diet and (-)-epicatechin (Epi) administration. Four groups of six male offspring from different litters were randomly selected for the control groups [C and offspring of mothers with maternal obesity (MO)] or Epi intervention groups. We evaluated the effect of Epi on gastrocnemius tissue by analysing the mRNA and protein expression levels of Fndc5/irisin, Pgc-1α, Ucp3, and Sln...
March 19, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38493976/a-21-day-safety-evaluation-of-biotechnologically-produced-3-fucosyllactose-3-fl-in-neonatal-farm-piglets-to-support-use-in-infant-formulas
#8
JOURNAL ARTICLE
Jeffrey Pitt, Jennifer Bond, Jason Roper, Paul Tenning, Ratna Mukherjea, Kara Evans, Markku T Saarinen, Heli Anglenius, Johanna Hirvonen, Oliver Hasselwander, Angela Lim
3-Fucosyllactose (3-FL) is one of the most abundant fucosylated oligosaccharides in human breast milk and is an approved infant formula ingredient world-wide. 3-FL functions as a prebiotic to promote early microbial colonization of the gut, increase pathogen resistance and modulate immune responses. To investigate safety and potential gut microbiota effects, 3-FL was fed for 21-days to farm piglets beginning on Postnatal Day (PND) 2. Fructooligosaccharide (FOS), an approved infant formula ingredient, was used as a reference control...
March 15, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38492615/the-impact-of-frailty-as-a-critical-mediator-causing-postoperative-neurocognitive-disorders-in-postoperative-cardiac-patients
#9
REVIEW
Hu Li, Jinfeng Li, Xin Huang, Bhushan Sandeep, Jing Yang
Frailty is prevalent in elderly cardiac patients and may be a critical predictor of post-operative neurocognitive disorders (PND). The aim of this review was to demonstrate the correlation of frailty with PND in postsurgical elder patients. A review of published literature and bibliometric analysis was undertaken. Electronic databases from 2009 to 2022 were searched to identify articles that evaluated the relationship between frailty and PND in aging populations. Demographic data, type of surgery performed, frailty measurement, and impact of frailty on PND were extracted from the selected studies...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38492413/eudragit-s100-coated-nanodiamond-based-nanoparticles-as-an-oral-chemo-photothermal-delivery-system-for-local-treatment-of-colon-cancer
#10
JOURNAL ARTICLE
Yupei Su, Hao Pan, Jiahui Wang, Dandan Liu, Weisan Pan
Oral colonic nano-drug delivery system has received more and more attention in the treatment of colon cancer due to local precision treatment and reduction of drug system distribution. However, the complex and harsh gastrointestinal environment and the retention of nanoparticles in the colon limit its development. To this end, we designed Eudragit S100 (ES) coated nanoparticles (ES@PND-PEG-TPP/DOX). Polydopamine coated nanodiamond (PND) was modified with amino-functionalized polyethylene glycol (NH2 -PEG-NH2 ) and triphenylphosphine (TPP) successively...
March 13, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38492326/impaired-ischemia-reperfusion-responses-in-the-hearts-of-aged-male-and-female-offspring-of-obese-rats
#11
JOURNAL ARTICLE
Carlos A Ibáñez, Francisco Correa, Gabriela Lira-León, Luis A Reyes-Castro, Francisco Javier Roldán, Alejandro Silva-Palacios, Mabel Buelna-Chontal, Guadalupe L Rodríguez-González, Peter W Nathanielsz, Cecilia Zazueta, Elena Zambrano
Maternal obesity predisposes offspring (F1) to cardiovascular disease. To evaluate basal heart function and ischemia-reperfusion (IR) responses in F1 males and females of obese mothers, female Wistar rats (F0) were fed chow or an obesogenic (MO) diet from weaning through pregnancy and lactation. Non-sibling F1 males and females were weaned to chow at postnatal day (PND) 21 and euthanized at PND 550. Offspring of MO mothers (MOF1) rarely survive beyond PND 650. Hearts were immediately isolated from euthanized F1s and subjected to 30 min ischemia with 20 min reperfusion...
March 15, 2024: Archives of Medical Research
https://read.qxmd.com/read/38490593/effect-of-ehealth-interventions-on-perinatal-depression-a-meta-analysis
#12
REVIEW
Hongyan Xie, Shengnan Cong, Rui Wang, Xiaoqing Sun, Jingjing Han, Shiqian Ni, Aixia Zhang
BACKGROUND: Perinatal depression (PND) is a common mental health problem, and eHealth interventions may provide a strategy for alleviating PND. AIM: This meta-analysis aimed to determine the effect of eHealth interventions on PND. METHODS: Six databases were searched to retrieve published randomized controlled trials (RCTs) on the effect of eHealth interventions on PND. A meta-analysis was performed on the data of these studies using a random effects model...
March 13, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38481647/late-onset-prosthetic-aortic-valve-stenosis-caused-by-pannus-formation
#13
Nicholas Roma, Kashyap Shah, Ketul Patel, Joshua Elmer, Bruce Ferraro, Prarthana Patel, Michael Durkin
UNLABELLED: Transcatheter aortic valve replacement (TAVR) is a less invasive alternative to an open surgical aortic valve replacement (SAVR) for treating severe symptomatic aortic stenosis. Despite gaining widespread acceptance and approval for use in patients with high, moderate, and low surgical risk, the increasing use of TAVR has raised concerns about potential short- and long-term complications. We present the case of a 69-year-old female who underwent TAVR and subsequently presented to our outpatient cardiology clinic with progressively worsening dyspnea, orthopnea, and paroxysmal nocturnal dyspnea two years after the procedure...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38481183/exploring-the-role-of-mitochondrial-associated-and-peripheral-neuropathy-genes-in-the-pathogenesis-of-diabetic-peripheral-neuropathy
#14
JOURNAL ARTICLE
Ruojing Bai, Yuanyuan Luo
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a prevalent and serious complication of diabetes mellitus, impacting the nerves in the limbs and leading to symptoms like pain, numbness, and diminished function. While the exact molecular and immune mechanisms underlying DPN remain incompletely understood, recent findings indicate that mitochondrial dysfunction may play a role in the advancement of this diabetic condition. METHODS: Two RNA transcriptome datasets (codes: GSE185011 and GSE95849), comprising samples from diabetic peripheral neuropathy (DPN) patients and healthy controls (HC), were retrieved from the Gene Expression Omnibus (GEO) database hosted by the National Center for Biotechnology Information (NCBI)...
March 13, 2024: BMC Neurology
https://read.qxmd.com/read/38476518/predicting-postsurgical-complications-of-peripheral-nerve-decompression-nsqip-analysis-of-frailty-measures-versus-historic-proxies
#15
JOURNAL ARTICLE
Arya A Akhavan, Helen Liu, Eric Alerte, Taylor Ibelli, Suhas K Etigunta, Abigail Katz, Annet S Kuruvilla, Peter J Taub
BACKGROUND: Peripheral nerve decompression (PND) is generally safe, and newer techniques allow frail patients to undergo PND at less common sites. Current literature suggests patient frailty measures may more accurately predict postsurgical complications versus other proxies, but no current literature examines frailty in PND. METHODS: The authors reviewed data from the National Surgical Quality Improvement Program for patients who underwent PND outside the most common sites from 2013 to 2019...
2024: Eplasty
https://read.qxmd.com/read/38467724/early-life-influenza-a-h1n1-infection-independently-programs-brain-connectivity-hpa-axis-and-tissue-specific-gene-expression-profiles
#16
JOURNAL ARTICLE
Myriam P Merz, Snehaa V Seal, Nathalie Grova, Sophie Mériaux, Pauline Guebels, Georgia Kanli, Elise Mommaerts, Nathalie Nicot, Tony Kaoma, Olivier Keunen, Petr V Nazarov, Jonathan D Turner
Early-life adversity covers a range of physical, social and environmental stressors. Acute viral infections in early life are a major source of such adversity and have been associated with a broad spectrum of later-life effects outside the immune system or "off-target". These include an altered hypothalamus-pituitary-adrenal (HPA) axis and metabolic reactions. Here, we used a murine post-natal day 14 (PND 14) Influenza A (H1N1) infection model and applied a semi-holistic approach including phenotypic measurements, gene expression arrays and diffusion neuroimaging techniques to investigate HPA axis dysregulation, energy metabolism and brain connectivity...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38461646/in-vitro-functional-analysis-and-in-silico-structural-modelling-of-pathogen-secreted-polyglycine-hydrolases
#17
JOURNAL ARTICLE
Todd A Naumann, Nicole V Dowling, Neil P J Price, David R Rose
Polyglycine hydrolases are fungal effectors composed of an N-domain with unique sequence and structure and a C-domain that resembles β-lactamases, with serine protease activity. These secreted fungal proteins cleave Gly-Gly bonds within a polyglycine sequence in corn ChitA chitinase. The polyglycine hydrolase N-domain (PND) function is unknown. In this manuscript we provide evidence that the PND does not directly participate in ChitA cleavage. In vitro analysis of site-directed mutants in conserved residues of the PND of polyglycine hydrolase Es-cmp did not specifically impair protease activity...
March 6, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38459988/protective-effect-of-alpha%C3%A2-lipoic-acid-against-in-utero-cytarabine-exposure-induced-hepatotoxicity-in-rat-female-neonates
#18
JOURNAL ARTICLE
Ramanachary Namoju, Kavitha N Chilaka
Cytarabine, an anti-metabolite drug, remains the mainstay of treatment for hematological malignancies. It causes various toxic effects including teratogenicity. Alpha lipoic acid (ALA) is a natural antioxidant reported to offer protection against hepatotoxicity induced by various pathological conditions, drugs, or chemicals. We investigated the protective effect of ALA against prenatal cytarabine exposure-induced hepatotoxicity in rat female neonates. A total of 30 dams were randomly assigned to five groups and received normal saline, ALA 200 mg/kg, cytarabine 12...
March 9, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38455793/patulous-eustachian-tube-and-otitis-media-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis-omaav
#19
Iori Kusaka, Ryoukichi Ikeda, Aya Katsura, Kiyoto Shiga
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a systemic necrotizing vasculitis that affects small to medium-sized vessels. We describe two cases of patulous Eustachian tube (PET) in patients with otitis media with ANCA-associated vasculitis (OMAAV). The two cases presented in this paper had previously been diagnosed with Eustachian tube (ET) stenosis, and both presented with bilateral aural fullness, with one also experiencing postnasal drip and hearing loss. Both patients experienced positive myeloperoxidase (MPO)-ANCA and negative proteinase 3 (PR3)-ANCA, and treatment for ANCA-associated vasculitis (AAV) resulted in a diagnosis of PET...
February 2024: Curēus
https://read.qxmd.com/read/38455582/a-single-24%C3%A2-h-maternal-separation-at-pnd-9-promotes-behavioral-resilience-of-female-c57bl-6j-mice-and-the-possible-role-of-hippocampal-homer1a
#20
JOURNAL ARTICLE
Yelu Hao, Yujie Niu, Fei Shi, Lei Zhang, Cheng Peng, Zhiqiang Yan, Xiaoyan Chen, Hongyu Xu
Early life stress (ELS) has been thought to increase vulnerability to developing psychiatric disorders later in life, while some researchers have found that adversity early in life may promote stress resilience. Studies investigating the resilient effect of maternal separation (MS) are still relatively few, and the underlying mechanisms remain unknown. In the current study, the effect of a single 24 h MS paradigm at postnatal day 9 (PND 9) in female C57BL/6J mice was investigated by assessing behavioral performance in middle adolescence...
March 15, 2024: Heliyon
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