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https://www.readbyqxmd.com/read/29785793/outcomes-associated-with-fetal-parvovirus-b19-infection-a-systematic-review-and-meta-analysis
#1
REVIEW
Francesca Bascietto, Marco Liberati, Daniela Murgano, Danilo Buca, Antonia Iacovelli, Maria Elena Flacco, Lamberto Manzoli, Alessandra Familiari, Giovanni Scambia, Francesco D'Antonio
OBJECTIVE: To explore the outcome of fetuses affected by congenital Parvovirus B19 (PB19) Infection. METHODS: The outcomes observed were: miscarriage, perinatal death (PND), intra-uterine death (IUD), neonatal death (NND), spontaneous resolution of hydrops or fetal anemia, intra-uterine transfusion (IUT), resolution of hydrops or anemia after transfusion, fetal loss following transfusion, abnormal brain scan after birth, abnormal neurodevelopmental outcome. All the observed outcomes were reported in fetuses presenting and in those not presenting signs of hydrops on ultrasound...
May 22, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29785228/evaluating-the-utility-of-a-structured-clinical-protocol-for-reducing-the-impact-of-behavioural-and-psychological-symptoms-of-dementia-in-progressive-neurological-diseases-a-pilot-study
#2
Nicholas P Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Objectives: Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntington's disease, and Parkinson's disease, the utility of a structured clinical protocol for reducing BPSD has not been systematically evaluated in PND populations. Method: Staff ( n = 51) and individuals with a diagnosis of PND ( n = 13) were recruited into the study, which aimed to evaluate the efficacy of a PND-specific structured clinical protocol for reducing the impact of BPSD in residential aged care (RAC) and specialist disability accommodation (SDA) facilities...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29783936/identifying-and-assessing-the-benefits-of-interventions-for-postnatal-depression-a-systematic-review-of-economic-evaluations
#3
Binu Gurung, Louise J Jackson, Mark Monahan, Ruth Butterworth, Tracy E Roberts
BACKGROUND: Economic evaluations of interventions for postnatal depression (PND) are essential to ensure optimal healthcare decision-making. Due to the wide-ranging effects of PND on the mother, baby and whole family, there is a need to include outcomes for all those affected and to include health and non-health outcomes for accurate estimates of cost-effectiveness. This study aimed to identify interventions to prevent or treat PND for which an economic evaluation had been conducted and to evaluate the health and non-health outcomes included...
May 21, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29782962/monosodium-glutamate-induced-nociception-and-oxidative-stress-dependent-on-time-of-administration-age-of-rats-and-susceptibility-of-spinal-cord-and-brain-regions
#4
Suzan Gonçalves Rosa, Pietro Maria Chagas, Ana Paula Pesarico, Cristina Wayne Nogueira
Monosodium glutamate (MSG), a food flavor enhancer used worldwide, has been studied because it may cause neurotoxicity, which is associated with oxidative stress. The aim of this study was to investigate whether spinal cord and brain regions are affected by oxidative stress and the temporal profile of nociceptive responses induced by MSG in newborn and adult rats. The newborn (post natal day, PND 1) Wistar rats received ten subcutaneous injections of MSG (4.0 g/kg) or saline solution. At PND 3, 11 or 90, the rats performed nociceptive tests and parameters of oxidative stress were evaluated in samples of spinal cord and brain regions...
May 18, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29778496/ascorbic-acid-co-administered-with-rosuvastatin-reduces-reproductive-impairment-in-the-male-offspring-from-male-rats-exposed-to-the-statin-at-pre-puberty
#5
Gabriel Adan Araújo Leite, Thamiris Moreira Figueiredo, Marina Trevizan Guerra, Cibele Dos Santos Borges, Fábio Henrique Fernandes, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas
Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound for male reproduction. Pre-pubertal male rats were distributed into six experimental groups that received saline solution 0.9% (vehicle), 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid by gavage from post-natal day (PND)23 until PND53...
May 17, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29773936/diabetes-prenatal-depression-and-self-rated-health-in-latina-mothers
#6
Sandraluz Lara-Cinisomo, Claire Swinford, Danielle Massey, Heidi Hardt
Background: Latinas in the United States have elevated rates of diabetes and prenatal depression (PND). The presence of diabetes and PND can also have a negative effect on women's self-rated health (SRH), a commonly used indicator of health that is consistent with objective health status and is a predictor of mortality. However, the associations between PND, diabetes, and SRH have not been tested, particularly among Latinas, who have elevated risk of both medical conditions. To address this gap, this pilot study tested the association between PND and diabetes using data from Latinas enrolled during their third trimester of pregnancy and explored whether these health conditions were associated with SRH in these women...
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29772815/longitudinal-effects-of-iron-deficiency-anemia-and-subsequent-repletion-on-blood-parameters-and-the-rate-and-composition-of-growth-in-pigs
#7
Laura C Knight, Ryan N Dilger
Iron deficiency is reported as the most common nutrient deficiency worldwide. Due to rapid growth, infants are at particular risk for developing iron deficiency, which can easily progress to iron deficiency anemia (IDA), if not treated. The aim of this study was to determine the lasting effects of an early-life iron deficiency after a period of dietary iron repletion. Forty-two intact male pigs were fed, ad libitum , either control (CONT, 21.3 mg Fe/L) or iron-deficient (ID 2.72 mg Fe/L) milk replacer from postnatal day (PND) 2 to 32 (phase 1)...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29764882/postnatal-depression-and-intimate-partner-violence-a-nationwide-clinic-based-cross-sectional-study-in-malaysia
#8
Noor Ani Ahmad, Umi Adzlin Silim, Azriman Rosman, Majdah Mohamed, Ying Ying Chan, Noraida Mohd Kasim, Muslimah Yusof, Mohamad Aznuddin Abd Razak, Maisarah Omar, Fazly Azry Abdul Aziz, Rasidah Jamaluddin, Fatanah Ismail, Nurashikin Ibrahim, Tahir Aris
INTRODUCTION: An estimated 13% of women in the postnatal period suffer from postnatal depression (PND) worldwide. In addition to underprivileged women, women who are exposed to violence are at higher risk of PND. This study aimed to investigate the relationship between intimate partner violence (IPV) and PND in Malaysia. METHODS: This survey was conducted as a nationwide cross-sectional study using a cluster sampling design. Probable PND was assessed using a self-administered Edinburgh Postnatal Depression Scale (EPDS)...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29763644/immunomodulatory-effect-of-celecoxib-on-hmgb1-tlr4-pathway-in-a-recurrent-seizures-model-in-immature-rats
#9
Mariana Morales-Sosa, Sandra Orozco-Suárez, AngélicaVega-García, Sara Caballero-Chacón, Iris A Feria-Romero
Epileptic seizures constitute an important problem in pediatric neurology during the developmental period. The frequency and nosological significance of seizures, as well as their association with epileptogenesis, may be related to underlying mechanisms such as neuroinflammation. Those mechanisms of response activate inflammatory molecules induced in the neurons, activated glial cells and endothelial cells via the key HMGB1/TLR4 pathway. In this study, the drug celecoxib (CCX) was used as a blocker of the cyclooxygenase 2 (COX-2) and HMGB1/TLR-4 pathways...
May 12, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29762647/maternal-low-protein-diet-impairs-prostate-growth-in-young-rat-offspring-and-induces-prostate-carcinogenesis-with-aging
#10
Sergio A A Santos, Ana C Camargo, Flávia B Constantino, Ketlin T Colombelli, Fernanda Mani, Jaqueline C Rinaldi, Suelen Franco, Luiz M F Portela, Bruno O S Duran, Wellerson R Scarano, Barry T Hinton, Sergio L Felisbino, Luis A Justulin
Carcinogenesis is frequently linked to genetic background, however, exposure to environmental risk factors has gained attention as the etiologic agent for several types of cancer, including prostate. The intrauterine microenvironment has been described as a preponderant factor for offspring health; and maternal exposure to insult has been linked to chronic disease in older offspring. Using a model of maternal exposure to low protein diet (LPD; 6% protein), we demonstrated that impairment of offspring rat prostatic growth on postnatal day (PND) 21 was associated with prostate carcinogenesis in older offspring (PND 540)...
May 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29759084/sex-differences-in-associations-between-maternal-deprivation-and-alterations-in-hippocampal-calcium-binding-proteins-and-cognitive-functions-in-rats
#11
Hongyu Xu, Yuqin Ye, Yelu Hao, Fei Shi, Zhiqiang Yan, Guohao Yuan, Yuefan Yang, Zhou Fei, Xiaosheng He
BACKGROUND AND OBJECTIVE: Adverse early-life experiences have been suggested as one of the key contributors to neurodevelopmental disorders, such that these experiences influence brain development, cognitive ability and mental health. Previous studies indicated that hippocampal levels of the calcium-binding proteins calretinin (CALR) and calbindin-D28k (CALB) changed in response to maternal deprivation (MD), a model for adverse early-life experiences. We investigated the effects of MD on hippocampal CALR and CALB protein levels and cognitive behaviors, and explored whether these effects were sex-related...
May 15, 2018: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/29758348/effect-of-prenatal-stress-on-%C3%A9-5-gaba-a-receptor-subunit-gene-expression-in-hippocampus-and-pilocarpine-induced-seizure-in-rats
#12
Mehrdad Nejatbakhsh, Ehsan Saboory, Morteza Bagheri
The GABAergic synapses go through structural and functional maturation during early brain development. Maternal stress alters GABAergic synapses in developing brain, which are associated with the pathophysiology of neuropsychiatric disorders in adults. The present study aimed to investigate the effect of prenatal restraint stress (PS) on pilocarpine-induced seizure and ɑ5 subunit of γ-amino butyric acid type A (GABAA ) receptor expression in hippocampus. Pregnant Wistar rats were subjected to PS at gestational days 15-17 and the pups were examined for susceptibility to seizure and ɑ5 subunit of GABAA receptor expression in hippocampus at postnatal days 14 and 21 (P14 and PND 21)...
May 11, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29753050/sex-specific-differences-in-corticosterone-secretion-behavioral-phenotypes-and-expression-of-trkb-t1-and-trkb-fl-receptor-isoforms-impact-of-systemic-trkb-inhibition-and-combinatory-stress-exposure-in-adolescence
#13
Idu Azogu, Jacky Liang, Helene Plamondon
Stress exposure has been implicated in the development of mood disorders, although little is known about the lasting effects of repeated stress during the adolescent period on sex-specific differences in endocrine and plasticity-signaling responses in adulthood. Using a 10-day combinatory stress paradigm (postnatal day (PND) 26 to 35), we examined sex-specific impact of adolescent stress and inhibition of tyrosine-related kinase B (TrkB) receptor (ANA-12; 0.5 mg/kg, i.p.) on 1) adolescent blood corticosterone levels, 2) adult locomotion and anxiety behavior, and 3) region-specific differences in endogenous TrkB full-length (TrkB...
May 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29741761/peptidome-analysis-of-lung-tissues-from-a-hyperoxia-induced-bronchopulmonary-dysplasia-mouse-model-insights-into-the-pathophysiological-process-of-bronchopulmonary-dysplasia
#14
Jing Yin, Xingyun Wang, Le Zhang, Xing Wang, Heng Liu, Yin Hu, Xiangyun Yan, Yongfeng Tang, Juan Wang, Zhengyin Li, Zhangbin Yu, Yan Cao, Shuping Han
The aim of this study was to identify and compare the peptidomic profiles of lung tissues from neonatal mice with and without bronchopulmonary dysplasia (BPD). Hyperoxia was used to establish the BPD mouse model. Lung tissues obtained on postnatal day (PND) 9 were processed for analysis via histological staining and label-free liquid chromatography-mass spectrometry (LC-MS/MS). Histological analysis of the lung sections from the BPD group showed significant alveolar simplification and aberrant pulmonary vascularization...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29741722/prenatal-exposure-to-bisphenol-a-analogues-on-male-reproductive-functions-in-mice
#15
Mingxin Shi, Nikola Sekulovski, James A MacLean, Kanako Hayashi
This study was performed to examine whether prenatal exposure to bisphenol (BP) A analogues, BPE and BPS, negatively impacts male reproductive functions and testis development using mice as a model. CD-1 mice were orally exposed to control treatment (corn oil), BPA, BPE, and BPS (0.5, 20, or 50 µg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) to birth. Although sperm counts were significantly reduced by BPA, BPE, or BPS on postnatal day (PND) 60, only BPE or BPS exposure remained low for sperm motility...
March 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29741604/impact-of-reimplantation-technique-of-supra-aortic-branches-in-total-arch-replacement-on-stroke-rate-and-survival-results-from-the-arch-registry
#16
Florian S Schoenhoff, David H Tian, Martin Misfeld, Konstantinos G Perreas, David Spielvogel, Friedrich W Mohr, Friedhelm Beyersdorf, Tristan D Yan, Thierry P Carrel
OBJECTIVES: Our objective was to evaluate the impact of reimplantation techniques of the supra-aortic branches in total arch replacement on the rates of permanent neurological deficit (PND) and survival. METHODS: We identified patients enrolled in the ARCH registry who underwent total arch replacement between 2000 and 2015 with either en bloc or separate reimplantation of the supra-aortic branches. RESULTS: A total of 3345 patients were included in the present analysis...
May 8, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29741247/prenatal-and-preimplantation-diagnosis-of-hemoglobinopathies
#17
REVIEW
C Vrettou, G Kakourou, T Mamas, J Traeger-Synodinos
The hemoglobinopathies, as a group, are one of the most common serious monogenic diseases in the world. An accepted and widely adopted approach to reduce the number of new cases involves carrier-screening programs, with the option of prenatal diagnosis (PND) or preimplantation diagnosis (preimplantation genetic testing for monogenic disease, PGT-M) for carrier couples. The aim of PND is to provide an accurate result as early in pregnancy as possible, which necessitates prior identification of the parental disease-causing mutations, as well as safe and timely biopsy of fetal material...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29740591/postnatal-and-adult-aortic-heart-valves-have-distinctive-transcriptional-profiles-associated-with-valve-tissue-growth-and-maintenance-respectively
#18
Emily Nordquist, Stephanie LaHaye, Casey Nagel, Joy Lincoln
Heart valves are organized connective tissues of high mechanical demand. They open and close over 100,000 times a day to preserve unidirectional blood flow by maintaining structure-function relationships throughout life. In affected individuals, structural failure compromises function and often leads to regurgitant blood flow and progressive heart failure. This is most common in degenerative valve disease due to age-related wear and tear, or congenital malformations. At present, the only effective treatment of valve disease is surgical repair or replacement and this is often impermanent and requires anti-coagulation therapy throughout life...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29739136/early-postnatal-valproic-acid-exposure-increase-the-protein-level-of-astrocyte-markers-in-frontal-cortex-of-rat
#19
Tamanna Jahan Mony, Jae Won Lee, Sung Soo Kim, Wanjoo Chun, Hee Jae Lee
Objective: In our previous study, it has been reported that valproic acid (VPA) effects gliogenesis and increases the number of glial precursor cells during the early postnatal period. However there is no specific report that whether this process is going on up to the age of mature brain development and the consequence effect of this ongoing gliogenesis process. Methods: As an ongoing study, using Immunoblotting analysis, we checked the level of glial protein and glial-derived factor markers in the frontal cortex of a rat brain at postnatal day (PND) 21...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29738946/tributyltin-exposure-induces-gut-microbiome-dysbiosis-with-increased-body-weight-gain-and-dyslipidemia-in-mice
#20
Hao Guo, Haotian Yan, Dong Cheng, Xinglong Wei, Ruirui Kou, Jiliang Si
Gut microbiome dysbiosis plays a profound role in the pathogenesis of obesity and tributyltin (TBT) has been found as an environmental obesogen. However, whether TBT could disturb gut microbiome and the relationship between obesity induced by TBT exposure and alteration in gut microbiota are still unknown. In order to assess the association between them, mice were exposed to TBTCl (50 μg kg-1 ) once every three days from postnatal days (PNDs) 24 to 54. The results demonstrated that TBT exposure resulted in increased body weight gain, lager visceral fat accumulation and dyslipidemia in male mice on PND 84...
May 3, 2018: Environmental Toxicology and Pharmacology
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