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https://www.readbyqxmd.com/read/27899119/clinical-outcome-and-hemodynamic-behavior-of-the-labcor-dokimos-plus-aortic-valve
#1
Torsten Christ, Konstantin Zhigalov, Wolfgang Konertz, Sebastian Holinski
BACKGROUND: The Labcor Dokimos Plus (LDP) is a stented externally mounted pericardial aortic bioprosthesis, which was recently introduced in Europe. Aims of the study are evaluation of operative and postoperative results as well as hemodynamic performance. METHODS: One hundred consecutive patients with a mean age of 65.9 ± 10.7 years (range 35-87) and a mean EuroSCORE II of 3.1 ± 3.9 (range 0.67-24.5) underwent aortic valve replacement with the LDP. Mean valve-size was 25...
November 29, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27594651/initial-experience-with-the-watchman%C3%A2-left-atrial-appendage-system-for-stroke-prevention-in-atrial-fibrillation-a-single-centre-registry
#2
Guillaume Bonnet, Erwan Salaun, Mathieu Pankert, Thomas Cuisset, Jean-Louis Bonnet
BACKGROUND: Left atrial appendage (LAA) closure using the WATCHMAN™ device (WM) may be considered in patients with non-valvular atrial fibrillation (AF) and a high-risk of stroke who are ineligible for long-term oral anticoagulation (OAC). AIM: To report our single-centre preliminary experience, focusing on feasibility, safety and short-term efficacy of this procedure. METHODS: Patients implanted from December 2013 to February 2014 were included...
September 1, 2016: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/27590218/edoxaban-versus-enoxaparin-warfarin-in-patients-undergoing-cardioversion-of-atrial-fibrillation-ensure-af-a-randomised-open-label-phase-3b-trial
#3
Andreas Goette, Jose L Merino, Michael D Ezekowitz, Dmitry Zamoryakhin, Michael Melino, James Jin, Michele F Mercuri, Michael A Grosso, Victor Fernandez, Naab Al-Saady, Natalya Pelekh, Bela Merkely, Sergey Zenin, Mykola Kushnir, Jindrich Spinar, Valeriy Batushkin, Joris R de Groot, Gregory Y H Lip
BACKGROUND: Edoxaban, an oral factor Xa inhibitor, is non-inferior for prevention of stroke and systemic embolism in patients with atrial fibrillation and is associated with less bleeding than well controlled warfarin therapy. Few safety data about edoxaban in patients undergoing electrical cardioversion are available. METHODS: We did a multicentre, prospective, randomised, open-label, blinded-endpoint evaluation trial in 19 countries with 239 sites comparing edoxaban 60 mg per day with enoxaparin-warfarin in patients undergoing electrical cardioversion of non-valvular atrial fibrillation...
October 22, 2016: Lancet
https://www.readbyqxmd.com/read/27177231/comparison-of-energy-supplements-during-prolonged-exercise-for-maintenance-of-cardiac-function-carbohydrate-only-versus-carbohydrate-plus-whey-or-casein-hydrolysate
#4
Tanja Oosthuyse, Aletta M E Millen
Cardiac function is often suppressed following prolonged strenuous exercise and this may occur partly because of an energy deficit. This study compared left ventricular (LV) function by 2-dimensional echocardiography and tissue Doppler imaging (TDI) before and after ∼2.5 h of cycling (2-h steady-state 60% peak aerobic power output plus 16 km time trial) in 8 male cyclists when they ingested either placebo, carbohydrate-only (CHO-only), carbohydrate-casein hydrolysate (CHO-casein), or carbohydrate-whey hydrolysate (CHO-whey)...
June 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27106042/chronic-plus-binge-ethanol-feeding-induces-myocardial-oxidative-stress-mitochondrial-and-cardiovascular-dysfunction-and-steatosis
#5
Csaba Matyas, Zoltan V Varga, Partha Mukhopadhyay, Janos Paloczi, Tamas Lajtos, Katalin Erdelyi, Balazs T Nemeth, Mintong Nan, Gyorgy Hasko, Bin Gao, Pal Pacher
Alcoholic cardiomyopathy in humans develops in response to chronic excessive alcohol consumption; however, good models of alcohol-induced cardiomyopathy in mice are lacking. Herein we describe mouse models of alcoholic cardiomyopathies induced by chronic and binge ethanol (EtOH) feeding and characterize detailed hemodynamic alterations, mitochondrial function, and redox signaling in these models. Mice were fed a liquid diet containing 5% EtOH for 10, 20, and 40 days (d) combined with single or multiple EtOH binges (5 g/kg body wt)...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/26130793/diagnostic-performance-of-left-atrial-diameter-measurement-in-computed-tomography-to-detect-increased-left-atrial-volume
#6
Mikko Taina, Valtteri Rissanen, Marja Hedman, Pekka Jäkälä, Vesa Järvinen, Ritva Vanninen, Petri Sipola
BACKGROUND/AIM: The left atrium (LA) is frequently imaged in cardiac computed tomographic (cCT) examinations. The LA volume can be accurately measured with three-dimensional (3D) volumetry but this method is time consuming and thus not routinely used in clinical practice. Accordingly, increased LA size may be overlooked although volume enlargement is associated with adverse cardiovascular events. We evaluated the accuracy of LA diameter measurement in cCT and in transthoracic echocardiography (TTE) in the diagnosis of LA enlargement using 3D cCT as the reference standard...
July 2015: In Vivo
https://www.readbyqxmd.com/read/24846173/rationale-and-study-design-of-the-neurocardiac-therapy-for-heart-failure-study-nectar-hf
#7
RANDOMIZED CONTROLLED TRIAL
Gaetano M De Ferrari, Anton E Tuinenburg, Stephen Ruble, Josep Brugada, Helmut Klein, Christian Butter, David J Wright, Bernd Schubert, Scott Solomon, Scott Meyer, Kenneth Stein, Agnes Ramuzat, Faiez Zannad
AIMS: Increased sympathetic activation and reduced parasympathetic tone are important pathophysiological contributors to the progression of heart failure, and are associated with poor outcome in patients. The aim of this study is to determine if vagal nerve stimulation (VNS) is a promising approach to modulate autonomic function and slow cardiac remodelling and the progression of heart failure. METHODS: The NECTAR-HF (NEural Cardiac TherApy foR Heart Failure) trial is designed to evaluate whether the Boston Scientific VNS device is safe and may attenuate cardiac remodelling, improve cardiac function and increase exercise capacity, in symptomatic heart failure patients (New York Heart Association Class II-III) with left ventricular systolic dysfunction (ejection fraction ≤35%) and receiving optimal medical therapy...
June 2014: European Journal of Heart Failure
https://www.readbyqxmd.com/read/24716681/fibrinolysis-for-patients-with-intermediate-risk-pulmonary-embolism
#8
RANDOMIZED CONTROLLED TRIAL
Guy Meyer, Eric Vicaut, Thierry Danays, Giancarlo Agnelli, Cecilia Becattini, Jan Beyer-Westendorf, Erich Bluhmki, Helene Bouvaist, Benjamin Brenner, Francis Couturaud, Claudia Dellas, Klaus Empen, Ana Franca, Nazzareno Galiè, Annette Geibel, Samuel Z Goldhaber, David Jimenez, Matija Kozak, Christian Kupatt, Nils Kucher, Irene M Lang, Mareike Lankeit, Nicolas Meneveau, Gerard Pacouret, Massimiliano Palazzini, Antoniu Petris, Piotr Pruszczyk, Matteo Rugolotto, Aldo Salvi, Sebastian Schellong, Mustapha Sebbane, Bozena Sobkowicz, Branislav S Stefanovic, Holger Thiele, Adam Torbicki, Franck Verschuren, Stavros V Konstantinides
BACKGROUND: The role of fibrinolytic therapy in patients with intermediate-risk pulmonary embolism is controversial. METHODS: In a randomized, double-blind trial, we compared tenecteplase plus heparin with placebo plus heparin in normotensive patients with intermediate-risk pulmonary embolism. Eligible patients had right ventricular dysfunction on echocardiography or computed tomography, as well as myocardial injury as indicated by a positive test for cardiac troponin I or troponin T...
April 10, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24458750/the-effect-of-lifelong-exercise-dose-on-cardiovascular-function-during-exercise
#9
COMPARATIVE STUDY
Graeme Carrick-Ranson, Jeffrey L Hastings, Paul S Bhella, Naoki Fujimoto, Shigeki Shibata, M Dean Palmer, Kara Boyd, Sheryl Livingston, Erika Dijk, Benjamin D Levine
An increased "dose" of endurance exercise training is associated with a greater maximal oxygen uptake (Vo2max), a larger left ventricular (LV) mass, and improved heart rate and blood pressure control. However, the effect of lifelong exercise dose on metabolic and hemodynamic response during exercise has not been previously examined. We performed a cross-sectional study on 101 (69 men) seniors (60 yr and older) focusing on lifelong exercise frequency as an index of exercise dose. These included 27 who had performed ≤ 2 exercise sessions/wk (sedentary), 25 who performed 2-3 sessions/wk (casual), 24 who performed 4-5 sessions/wk (committed) and 25 who performed ≥ 6 sessions/wk plus regular competitions (Masters athletes) over at least the last 25 yr...
April 1, 2014: Journal of Applied Physiology
https://www.readbyqxmd.com/read/24431166/effects-of-tricuspid-valve-surgery-on-tricuspid-regurgitation-in-patients-with-hypoplastic-left-heart-syndrome-a-non-randomized-series-comparing-surgical-and-non-surgical-cases
#10
COMPARATIVE STUDY
Junya Sugiura, Toshihide Nakano, Shinichiro Oda, Akihiko Usui, Yuichi Ueda, Hideaki Kado
OBJECTIVES: Tricuspid regurgitation (TR) remains a significant risk factor affecting the survival of patients with hypoplastic left heart syndrome (HLHS). We performed this study to investigate differences in the clinical course based on the timing of the development of TR and the effects of tricuspid valve surgery (TVS). METHODS: One hundred and five patients of classic HLHS underwent staged operations from May 1991 to July 2010. Forty-four patients (41.9%) exhibited moderate or greater TR during the follow-up...
July 2014: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/24344038/can-the-epirubicin-cardiotoxicity-in-cancer-patients-be-prevented-by-angiotensin-converting-enzyme-inhibitors
#11
D Radulescu, E Buzdugan, T E Ciuleanu, N Todor, L Stoicescu
PURPOSE: The aim of this study was to assess whether treatment with angiotensin converting enzyme inhibitors (ACEI) can prevent the alteration of left ventricular systolic and diastolic performance in cancer patients treated with different chemotherapy regimens containing epirubicin. METHODS: In this prospective study , 68 patients with different malignant tumors treated with epirubicin and perindopril in different chemotherapy protocols (study group), and a gender- and age-matched group of 68 patients with different malignant tumors treated with epirubicin without perindopril in different chemotherapy protocols (control group), were assessed by Doppler echocardiography...
October 2013: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/24280710/role-of-myocardial-hypertrophy-on-acute-and-chronic-right-ventricular-performance-in-relation-to-chronic-volume-overload-in-a-porcine-model-relevance-for-the-surgical-management-of-tetralogy-of-fallot
#12
COMPARATIVE STUDY
Thierry Bove, Kristof Vandekerckhove, Stefaan Bouchez, Patrick Wouters, Pamela Somers, Guido Van Nooten
OBJECTIVES: The age for correction of tetralogy of Fallot has progressively declined to the postnatal period, often despite an increased rate of transannular patch repair. However, the long-term effect of premature exposure to chronic pulmonary insufficiency on the right ventricle remains unknown. On the basis of the relationship between the duration of pressure overload and age, the role of previous pressure load-related hypertrophy on right ventricular (RV) performance after chronic volume overload was investigated in a porcine model...
June 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24257807/impact-of-repeated-intravenous-bone-marrow-mesenchymal-stem-cells-infusion-on-myocardial-collagen-network-remodeling-in-a-rat-model-of-doxorubicin-induced-dilated-cardiomyopathy
#13
Qin Yu, Qianxiao Li, Rongmei Na, Xiaofei Li, Baiting Liu, Lili Meng, Hanyu Liutong, Weiyi Fang, Ning Zhu, Xiaoqun Zheng
Bone marrow mesenchymal stem cells (MSCs) transplantation improved cardiac function and reduced myocardial fibrosis in both ischemic and non-ischemic cardiomyopathies. We evaluated the effects of repeated peripheral vein injection of MSCs on collagen network remodeling and myocardial TGF-β1, AT1, CYP11B2 (aldosterone synthase) gene expressions in a rat model of doxorubicin (DOX)-induced dilated cardiomyopathy (DCM). Thirty-eight out of 53 SD rats survived at 10 weeks post-DOX injection (2.5 mg/kg/week for 6 weeks, i...
February 2014: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/24200688/association-of-novel-biomarkers-of-cardiovascular-stress-with-left-ventricular-hypertrophy-and-dysfunction-implications-for-screening
#14
Vanessa Xanthakis, Martin G Larson, Kai C Wollert, Jayashri Aragam, Susan Cheng, Jennifer Ho, Erin Coglianese, Daniel Levy, Wilson S Colucci, G Michael Felker, Emelia J Benjamin, James L Januzzi, Thomas J Wang, Ramachandran S Vasan
BACKGROUND: Currently available screening tools for left ventricular (LV) hypertrophy (LVH) and systolic dysfunction (LVSD) are either expensive (echocardiography) or perform suboptimally (B-type natriuretic peptide [BNP]). It is unknown whether newer biomarkers are associated with LVH and LVSD and can serve as screening tools. METHODS AND RESULTS: We studied 2460 Framingham Study participants (mean age 58 years, 57% women) with measurements of biomarkers mirroring cardiac biomechanical stress (soluble ST-2 [ST2], growth differentiation factor-15 [GDF-15] and high-sensitivity troponin I [hsTnI]) and BNP...
November 7, 2013: Journal of the American Heart Association
https://www.readbyqxmd.com/read/24080362/nt-prob-natriuretic-peptide-risk-factors-and-asymptomatic-left-ventricular-dysfunction-results-of-the-screening-evaluation-of-the-evolution-of-new-heart-failure-study-screen-hf
#15
Michele McGrady, Christopher M Reid, Louise Shiel, Rory Wolfe, Umberto Boffa, Danny Liew, Duncan J Campbell, David Prior, Simon Stewart, Henry Krum
BACKGROUND: We assessed left ventricular dysfunction in a population at high risk for heart failure (HF), and explored associations between ventricular function, HF risk factors and NT-proB natriuretic peptide (NT-proBNP). METHODS AND RESULTS: 3550 subjects at high risk for incident HF (≥60 years plus ≥1 HF risk factor), but without pre-existing HF or left ventricular dysfunction, were recruited. Anthropomorphic data, medical history and blood for NT-proBNP were collected...
October 30, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23856201/effect-of-systematic-downsizing-rigid-ring-annuloplasty-in-patients-with-moderate-ischemic-mitral-regurgitation
#16
RANDOMIZED CONTROLLED TRIAL
Denis Bouchard, Henrik Jensen, Michel Carrier, Philippe Demers, Michel Pellerin, Louis P Perrault, Jean Lambert
OBJECTIVE: Functional ischemic mitral regurgitation (FIMR) increases mortality independently of the baseline characteristics and ventricular function. The effect of treating FIMR with annuloplasty is unclear when mitral regurgitation is moderate. Myocardial revascularization alone has been shown to improve mitral valve function. METHODS: We randomized 31 patients with moderate (grade 2-4) FIMR to receive either coronary artery bypass grafting (CABG) alone or CABG plus downsizing mitral ring annuloplasty...
May 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/23787233/risk-factors-for-thrombus-formation-on-the-amplatzer-cardiac-plug-after-left-atrial-appendage-occlusion
#17
Bjoern Plicht, Thomas F M Konorza, Philipp Kahlert, Fadi Al-Rashid, Hagen Kaelsch, Rolf Alexander Jánosi, Thomas Buck, Hagen S Bachmann, Winfried Siffert, Gerd Heusch, Raimund Erbel
OBJECTIVES: This study sought to identify risk factors for thrombus formation on the Amplatzer Cardiac Plug (ACP) (St. Jude Medical, St. Paul, Minnesota) after left atrial appendage occlusion. BACKGROUND: Left atrial appendage occlusion with the ACP aims to reduce the risk of embolic stroke and bleeding complications associated with vitamin K antagonists in patients with atrial fibrillation. METHODS: We performed transesophageal echocardiography before discharge and after 3, 6, and 12 months in 34 patients with atrial fibrillation undergoing ACP implantation and receiving dual antiplatelet therapy...
June 2013: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/23644256/ibuprofen-plus-isosorbide-dinitrate-treatment-in-the-mdx-mice-ameliorates-dystrophic-heart-structure
#18
Clara Sciorati, Lidia Staszewsky, Vanessa Zambelli, Ilaria Russo, Monica Salio, Deborah Novelli, Giuseppe Di Grigoli, Rosa Maria Moresco, Emilio Clementi, Roberto Latini
BACKGROUND: Co-administration of ibuprofen (IBU) and isosorbide dinitrate (ISDN) provides synergistic beneficial effects on dystrophic skeletal muscle. Whether this treatment has also cardioprotective effects in this disease was still unknown. AIMS: To evaluate the effects of co-administration of IBU and ISDN (a) on left ventricular (LV) structure and function, and (b) on cardiac inflammatory response and fibrosis in mdx mice. METHODS: Three groups of mice were studied: mdx mice treated with IBU (50 mg kg⁻¹)+ISDN (30 mg kg⁻¹) administered daily in the diet, mdx mice that received standard diet without drugs and wild type aged-matched mice...
July 2013: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/23537813/circulating-matrix-metalloproteinases-and-tissue-inhibitors-of-metalloproteinases-in-cardiac-amyloidosis
#19
COMPARATIVE STUDY
Komei Tanaka, Eric E Essick, Gheorghe Doros, Kahraman Tanriverdi, Lawreen H Connors, David C Seldin, Flora Sam
BACKGROUND: Cardiac amyloidosis due to amyloid fibril deposition in the heart results in cardiomyopathy (CMP) with heart failure (HF) and/or conduction disturbances. Immunoglobulin light chain-related CMP (AL-CMP) features rapidly progressive HF with an extremely poor prognosis compared with a CMP due to the deposition of mutant (ATTR) amyloidosis or wild-type (senile systemic amyloidosis, SSA) transthyretin (TTR) proteins. Amyloid fibril deposition disrupts the myocardial extracellular matrix (ECM) homeostasis, which is partly regulated by matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs)...
March 12, 2013: Journal of the American Heart Association
https://www.readbyqxmd.com/read/23500234/inducible-myocardial-ischemia-and-outcomes-in-patients-with-coronary-artery-disease-and-left-ventricular-dysfunction
#20
RANDOMIZED CONTROLLED TRIAL
Julio A Panza, Thomas A Holly, Federico M Asch, Lilin She, Patricia A Pellikka, Eric J Velazquez, Kerry L Lee, Salvador Borges-Neto, Pedro S Farsky, Robert H Jones, Daniel S Berman, Robert O Bonow
OBJECTIVES: The study objectives were to test the hypotheses that ischemia during stress testing has prognostic value and identifies those patients with coronary artery disease (CAD) with left ventricular (LV) dysfunction who derive the greatest benefit from coronary artery bypass grafting (CABG) compared with medical therapy. BACKGROUND: The clinical significance of stress-induced ischemia in patients with CAD and moderately to severely reduced LV ejection fraction (EF) is largely unknown...
May 7, 2013: Journal of the American College of Cardiology
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