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https://www.readbyqxmd.com/read/28722648/perspectives-on-the-pure-tone-audiogram
#1
REVIEW
Frank E Musiek, Jennifer Shinn, Gail D Chermak, Doris-Eva Bamiou
BACKGROUND: The pure-tone audiogram, though fundamental to audiology, presents limitations, especially in the case of central auditory involvement. Advances in auditory neuroscience underscore the considerably larger role of the central auditory nervous system (CANS) in hearing and related disorders. Given the availability of behavioral audiological tests and electrophysiological procedures that can provide better insights as to the function of the various components of the auditory system, this perspective piece reviews the limitations of the pure-tone audiogram and notes some of the advantages of other tests and procedures used in tandem with the pure-tone threshold measurement...
July 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28721746/a-new-calm-a-story-of-breakthrough-neuroscience-technology-patented-to-quickly-and-naturally-reduce-stress-and-improve-performance
#2
Dan Jenkins
No abstract text is available yet for this article.
July 19, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28721669/mimicking-parkinson-s-disease-in-a-dish-merits-and-pitfalls-of-the-most-commonly-used-dopaminergic-in-vitro-models
#3
REVIEW
Fernanda Martins Lopes, Ivi Juliana Bristot, Leonardo Lisbôa da Motta, Richard B Parsons, Fabio Klamt
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has both unknown etiology and non-curative therapeutic options. Patients begin to present the classic motor symptoms of PD-tremor at rest, bradykinesia and rigidity-once 50-70% of the dopaminergic neurons of the nigrostriatal pathway have degenerated. As a consequence of this, it is difficult to investigate the early-stage events of disease pathogenesis. In vitro experimental models are used extensively in PD research because they present a controlled environment that enables the direct investigation of the early molecular mechanisms that are potentially involved with dopaminergic degeneration, as well as for the screening of potential therapeutic drugs...
July 18, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28721512/beyond-the-institutionalized-fetish-of-the-neurosciences-taking-brain-seriously
#4
Jaan Valsiner
In their book Kritik der Neuropsychologie (Giessen: Psychosozial Verlag, 2016, 123 pp. ISBN 978-3-8379-2563-0), Hans Werbik and Gerhard Benetka provide a thorough analysis of the modus operandi of our contemporary neurosciences and their success in promising the public and funding institutions great breakthroughs in understanding the human mind through the study of the brain. As the authors prove such promises are inadequate given the qualities of the human psyche that cannot be reduced to the complex mechanisms of the activation of brain circuits because there cannot be isomorphism between the brain and the ongoing dynamic relating of the mind with the flow of subjective experiencing...
July 18, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28719603/the-%C3%A2-100-lab-a-3d-printable-open-source-platform-for-fluorescence-microscopy-optogenetics-and-accurate-temperature-control-during-behaviour-of-zebrafish-drosophila-and-caenorhabditis-elegans
#5
Andre Maia Chagas, Lucia L Prieto-Godino, Aristides B Arrenberg, Tom Baden
Small, genetically tractable species such as larval zebrafish, Drosophila, or Caenorhabditis elegans have become key model organisms in modern neuroscience. In addition to their low maintenance costs and easy sharing of strains across labs, one key appeal is the possibility to monitor single or groups of animals in a behavioural arena while controlling the activity of select neurons using optogenetic or thermogenetic tools. However, the purchase of a commercial solution for these types of experiments, including an appropriate camera system as well as a controlled behavioural arena, can be costly...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28718304/the-role-of-surgery-in-low-grade-gliomas-do-timing-and-extent-of-resection-matter
#6
Hugues Duffau
Hugues Duffau is a Professor and Chairman of the Neurosurgery Department in the Montpellier University Medical Center and Head of the INSERM 1051 Team "plasticity of the central nervous system, human stem cells and glial tumors" at the Institute for Neurosciences of Montpellier (France). He is an expert in the awake cognitive neurosurgery of slow-growing brain tumors, such as low-grade gliomas, a routine which he has developed since 20 years. His fundamental approach is centered on the concepts of the brain connectomics and neuroplasticity, breaking with the traditional localizationist view of cerebral processing...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28717820/differences-between-endogenous-attention-to-spatial-locations-and-sensory-modalities
#7
J Vibell, C Klinge, M Zampini, A C Nobre, C Spence
Vibell et al. (J Cogn Neurosci 19:109-120, 2007) reported that endogenously attending to a sensory modality (vision or touch) modulated perceptual processing, in part, by the relative speeding-up of neural activation (i.e., as a result of prior entry). However, it was unclear whether it was the fine temporal discrimination required by the temporal-order judgment task that was used, or rather, the type of attentional modulation (spatial locations or sensory modalities) that was responsible for the shift in latencies that they observed...
July 17, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28717570/chip-on-the-tip-compact-flexible-endoscopic-epifluorescence-video-microscope-for-in-vivo-imaging-in-medicine-and-biomedical-research
#8
Gregor Matz, Bernhard Messerschmidt, Werner Göbel, Severin Filser, Christian S Betz, Matthias Kirsch, Ortrud Uckermann, Marcel Kunze, Sven Flämig, André Ehrhardt, Klaus-Martin Irion, Mareike Haack, Mario M Dorostkar, Jochen Herms, Herbert Gross
We demonstrate a 60 mg light video-endomicroscope with a cylindrical shape of the rigid tip of only 1.6 mm diameter and 6.7 mm length. A novel implementation method of the illumination unit in the endomicroscope is presented. It allows for the illumination of the biological sample with fiber-coupled LED light at 455 nm and the imaging of the red-shifted fluorescence light above 500 nm in epi-direction. A large numerical aperture of 0.7 leads to a sub-cellular resolution and yields to high-contrast images within a field of view of 160 μm...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28716272/the-need-for-a-global-neurology-alliance
#9
William M Carroll
BACKGROUND: With increasing rapidity of advances in neuroscience and widening gaps in the accessibility to quality neurological care the risks of unpreparedness are growing. METHOD: To summarise the potential risks to the equal provision of neurological care and the resources available to improve the ability to plan and respond to the unexpected. RESULTS: To describe three examples of cooperative effort involving the World Federation of Neurology acting in concert with other neurological organisations...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28716096/optimizing-reproducibility-of-operant-testing-through-reinforcer-standardization-identification-of-key-nutritional-constituents-determining-reward-strength-in-touchscreens
#10
Eun Woo Kim, Benjamin U Phillips, Christopher J Heath, So Yeon Cho, Hyunjeong Kim, Jemeen Sreedharan, Ho-Taek Song, Jong Eun Lee, Timothy J Bussey, Chul Hoon Kim, Eosu Kim, Lisa M Saksida
Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to the possibility of universal standard protocols, in addition to increased translational potential, reliability and accuracy. However, the impact of regional and national differences in the supplies of available reinforcers in this system on behavioural performance and inter-laboratory variability is an unknown and at present uncontrolled variable...
July 17, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28714713/promoting-transparency-and-reproducibility-in-behavioral-neuroscience-publishing-replications-registered-reports-and-null-results
#11
Mark G Baxter, Rebecca D Burwell
The editors of Behavioral Neuroscience have been discussing several recent developments in the landscape of scientific publishing. The discussion was prompted, in part, by reported issues of reproducibility and concerns about the integrity of the scientific literature. Although enhanced rigor and transparency in science are certainly important, a related issue is that increased competition and focus on novel findings has impeded the extent to which the scientific process is cumulative. We have decided to join the growing number of journals that are adopting new reviewing and publishing practices to address these problems...
August 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28714062/splitting-the-difference-new-insights-into-distinguishing-features-of-human-versus-feline-models-of-adaptive-locomotor-control
#12
James M Finley
If you open most any neuroscience textbook and begin reading about the neural control of locomotion, you are almost guaranteed to find information gleaned from experimental studies of cats with spinal transections. This article is protected by copyright. All rights reserved.
July 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28713866/implications-of-the-hierarchical-structure-of-psychopathology-for-psychiatric-neuroimaging
#13
David H Zald, Benjamin B Lahey
Research into the neurobiological substrates of psychopathology has been impeded by heterogeneity within diagnostic categories, comorbidity among mental disorders, and the presence of symptoms that transcend diagnostic categories. Solutions to these issues increasingly focus neurobiological research on isolated or narrow groupings of symptoms or functional constructs rather than categorical diagnoses. Here we argue for a more integrative approach that also incorporates the broad hierarchical structure of psychopathological symptoms and their etiological mechanisms...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28713493/a-new-strategy-in-neurocritical-care-nurse-continuing-stroke-education-a-hybrid-simulation-pilot-study
#14
Christopher Ryan Newey, Robert Bell, Melody Burks, Premkumar Nattanmai
INTRODUCTION: High-fidelity simulation is frequently utilized in medical education. Its use in the neurosciences is limited by the inherent limitations of the manikin to simulate neurological changes. We report here the use of a hybrid simulation - a combination of lecture and high-fidelity manikin - in the education of neurosciences nurses, involved in care of neurocritical care patients. METHODS: Neurosciences nurses from at the University of Missouri, Columbia, MO, USA, which is an academic, tertiary-care medical center participated in the simulation during Spring of 2016...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28713325/editorial-the-role-of-the-distinctions-between-identification-production-and-perceptual-conceptual-processes-in-implicit-memory-findings-from-cognitive-psychology-neuroscience-and-neuropsychology
#15
EDITORIAL
https://www.readbyqxmd.com/read/28713008/determining-myeloperoxidase-activity-and-protein-concentration-in-a-single-assay-utility-in-biomarker-and-therapeutic-studies
#16
Muir Russell, Nina Prokoph, Neil Henderson, Susanna Eketjäll, Clare A Balendran, Erik Michaëlsson, Mark Fidock, Glen Hughes
Myeloperoxidase (MPO) is predominantly expressed by neutrophils and is an important enzyme used by the immune system for the neutralisation of bacteria and other microorganisms. The strong oxidative activity of MPO has been linked to pro-inflammatory responses in surrounding cells and tissues with implication in the pathophysiology of cardiovascular, neuroscience and inflammatory diseases. This broad disease association has made MPO an attractive biomarker and therapeutic target. Here we describe the construction and validation of a single combined MPO activity and protein concentration assay using commercially available reagents...
July 13, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28712994/recognition-of-white-matter-bundles-using-local-and-global-streamline-based-registration-and-clustering
#17
REVIEW
Eleftherios Garyfallidis, Marc-Alexandre Côté, Francois Rheault, Jasmeen Sidhu, Janice Hau, Laurent Petit, David Fortin, Stephen Cunanne, Maxime Descoteaux
Virtual dissection of diffusion MRI tractograms is cumbersome and needs extensive knowledge of white matter anatomy. This virtual dissection often requires several inclusion and exclusion regions-of-interest that make it a process that is very hard to reproduce across experts. Having automated tools that can extract white matter bundles for tract-based studies of large numbers of people is of great interest for neuroscience and neurosurgical planning. The purpose of our proposed method, named RecoBundles, is to segment white matter bundles and make virtual dissection easier to perform...
July 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28712664/gsk3-and-its-interactions-with-the-pi3k-akt-mtor-signalling-network
#18
REVIEW
Miguel A Hermida, J Dinesh Kumar, Nick R Leslie
Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and its phosphorylation of its diverse substrates has major influences on many areas of physiology and pathology, including cellular metabolism, lineage commitment and neuroscience. GSK3 was one of the first identified substrates of the heavily studied oncogenic kinase AKT, phosphorylation by which inhibits GSK3 activity via the formation of an autoinhibitory pseudosubstrate sequence. This has led to investigation of the role of GSK3 inhibition as a key component of the cellular responses to growth factors and insulin, which stimulate the class I PI 3-Kinases and in turn AKT activity and GSK3 phosphorylation...
June 27, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28711631/corrigendum-to-osteopontin-metallothionein-i-ii-interactions-in-experimental-autoimmune-encephalomyelitis-neuroscience-350-2017-133-145
#19
Hrvoje Jakovac, Tanja Grubić Kezele, Sandrašuć Urović, Biserka Mulac-Jeričević, Biserka Radošević-Stašić
No abstract text is available yet for this article.
July 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28710040/evaluating-the-replicability-specificity-and-generalizability-of-connectome-fingerprints
#20
Lea Waller, Henrik Walter, Johann D Kruschwitz, Lucia Reuter, Sabine Müller, Susanne Erk, Ilya M Veer
Establishing reliable, robust, and unique brain signatures from neuroimaging data is a prerequisite for precision psychiatry, and therefore a highly sought-after goal in contemporary neuroscience. Recently, the procedure of connectome fingerprinting, using brain functional connectivity profiles as such signatures, was shown to be able to accurately identify individuals from a group of 126 subjects from the Human Connectome Project (HCP). However, the specificity and generalizability of this procedure were not tested...
July 11, 2017: NeuroImage
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