keyword
MENU ▼
Read by QxMD icon Read
search

TRH

keyword
https://www.readbyqxmd.com/read/28736852/successful-medical-treatment-of-an-aspergillus-terreus-mycetoma-of-the-nostril-lip-in-a-16-year-old-fjord-pony-gelding-with-pituitary-pars-intermedia-dysfunction
#1
Pia K Randleff-Rasmussen, Marion Mosca, Frédéric Knoerr, Didier Pin, Isabelle Desjardins
BACKGROUND: Mycetoma is a chronic, proliferative lesion of cutaneous/subcutaneous tissue characterized by draining tracts and granules in the discharge caused by actinomycetes (actinomycetoma) or filamentous fungi (eumycotic mycetoma). OBJECTIVES: This case report describes the unusual finding of a cutaneous mycetoma of the lateral wing of the right nostril in a gelding. ANIMAL: A 16-year-old Fjord gelding with suspected pituitary pars intermedia dysfunction (PPID) was presented for evaluation of a nonpainful, firm and raised mass involving the lateral wing of the right nostril and the lip...
July 23, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28720519/taltirelin-alleviates-fatigue-like-behavior-in-mouse-models-of-cancer-related-fatigue
#2
John P Dougherty, Brian S Wolff, Mary J Cullen, Leorey N Saligan, Marvin C Gershengorn
Fatigue affects most cancer patients and has numerous potential causes, including cancer itself and cancer treatment. Cancer-related fatigue (CRF) is not relieved by rest, can decrease quality of life, and has no FDA-approved therapy. Thyrotropin-releasing hormone (TRH) has been proposed as a potential novel treatment for CRF, but its efficacy against CRF remains largely untested. Thus, we tested the TRH analog, taltirelin (TAL), in mouse models of CRF. To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors...
July 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28687650/parallel-evolution-of-two-clades-of-a-major-atlantic-endemic-vibrio-parahaemolyticus-pathogen-lineage-by-independent-acquisition-of-related-pathogenicity-islands
#3
Feng Xu, Narjol Gonzalez-Escalona, Kevin P Drees, Robert P Sebra, Vaughn S Cooper, Stephen H Jones, Cheryl A Whistler
Shellfish-transmitted Vibrio parahaemolyticus infections have recently increased from locations with historically low disease incidence, such as the Northeast United States (US). This change coincided with a bacterial population shift towards human pathogenic variants occurring in part through the introduction of several Pacific native lineages (ST36, ST43 and ST636) to near-shore areas off the Atlantic coast of the Northeast US. Concomitantly, ST631 emerged as a major endemic pathogen. Phylogenetic trees of clinical and environmental isolates indicated that two clades diverged from a common ST631 ancestor, and in each of these clades, a human pathogenic variant evolved independently through acquisition of distinct Vibrio pathogenicity islands (VPaI)...
July 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28686898/prenatal-transfer-of-decabromodiphenyl-ether-bde-209-results-in-disruption-of-the-thyroid-system-and-developmental-toxicity-in-zebrafish-offspring
#4
Zhihua Han, Yufei Li, Shenghu Zhang, Ninghui Song, Huaizhou Xu, Yao Dang, Chunsheng Liu, John P Giesy, Hongxia Yu
Decabromodiphenyl ether (BDE-209) was one of most widely-used polybrominated diphenyl ether (PBDE) flame retardants and is frequently detected in both abiotic and biotic samples from environment. However, knowledge of its transgenerational risks is limited. Here, 4-month-old zebrafish were exposed to various concentrations of BDE-209 (0, 3, 30 or 300μg/L) for 28days and spawned in clean water without BDE-209. Concentrations of triiodothyronine (T3) and thyroxine (T4) as well as expressions of genes involved in the hypothalamic-pituitary-thyroid (HPT) axis were measured in offspring after exposure of adult zebrafish to BDE-209...
June 23, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28678810/characterization-of-clinical-vibrio-parahaemolyticus-strains-in-zhoushan-china-from-2013-to-2014
#5
Hongling Wang, Xiaoyang Tang, Yi-Cheng Su, Jiabei Chen, Jianbo Yan
Vibrio parahaemolyticus is recognized as major cause of foodborne illness of global public health concern. This study collected 107 strains of V. parahaemolyticus during active surveillance of diarrheal diseases in hospitals in Zhoushan during 2013 to 2014 and investigated their serotypes, virulence genes (tdh, trh, and orf8), antimicrobial resistance, and genotypes. The dominant serotypes of the 107 clinical strains were O3:K6, O4:K8, and O4:KUT with 87.9% and 3.7% of the strains carrying the virulence genes tdh and trh, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28659901/prevalence-and-antimicrobial-susceptibility-of-vibrio-parahaemolyticus-isolated-from-short-mackerels-rastrelliger-brachysoma-in-malaysia
#6
Chia W Tan, Tan T H Malcolm, Chee H Kuan, Tze Y Thung, Wei S Chang, Yuet Y Loo, Jayasekara M K J K Premarathne, Othman B Ramzi, Mohd F S Norshafawatie, Nordin Yusralimuna, Yaya Rukayadi, Yoshitsugu Nakaguchi, Mitsuaki Nishibuchi, Son Radu
Numerous prevalence studies and outbreaks of Vibrio parahaemolyticus infection have been extensively reported in shellfish and crustaceans. Information on the quantitative detection of V. parahaemolyticus in finfish species is limited. In this study, short mackerels (Rastrelliger brachysoma) obtained from different retail marketplaces were monitored with the presence of total and pathogenic strains of V. parahaemolyticus. Out of 130 short mackerel samples, 116 (89.2%) were detected with the presence of total V...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28642752/a-comprehensive-epidemiological-research-for-clinical-vibrio-parahaemolyticus-in-shanghai
#7
Huan Li, Rong Tang, Yang Lou, Zelin Cui, Wenjing Chen, Qing Hong, Zhaohuan Zhang, Pradeep K Malakar, Yingjie Pan, Yong Zhao
Vibrio parahaemolyticus is one of the most important pathogen for seafood-borne gastroenteritis in Shanghai and the rest of the world. A total of 42 V. parahaemolyticus strains were isolated from 1900 fecal specimens collected from patients in Shanghai hospital presenting from January 2014 to December 2015. All isolates were evaluated for potential virulence factors [tdh, trh, and type three secretion system (T3SS) genes], typed using multilocus sequence typing (MLST) and screened for antimicrobial resistance phenotype and genotype...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28621684/expression-of-hypothalamic-neurohormones-and-their-receptors-in-the-human-eye
#8
Sander R Dubovy, Maria P Fernandez, Jose J Echegaray, Norman L Block, Noriyuki Unoki, Roberto Perez, Irving Vidaurre, Richard K Lee, Mehrdad Nadji, Andrew V Schally
Extrapituitary roles for hypothalamic neurohormones have recently become apparent and clinically relevant, based on the use of synthetic peptide analogs for the treatment of multiple conditions including cancers, pulmonary edema and myocardial infarction. In the eye, it has been suggested that some of these hormones and their receptors may be present in the ciliary body, iris, trabecular meshwork and retina, but their physiological role has yet to be elucidated. Our study intends to comprehensively demonstrate the expression of some hypothalamic neuroendocrine hormones and their receptors within different retinal and extraretinal structures of the human eye...
June 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28597403/resistant-hypertension-mechanisms-and-treatment
#9
REVIEW
Andrew Y Hwang, Eric Dietrich, Carl J Pepine, Steven M Smith
PURPOSE OF REVIEW: Emerging evidence suggests that multiple mechanisms may be responsible for the development of treatment-resistant hypertension (TRH). This review aims to summarize recent data on potential mechanisms of resistance and discuss current pharmacotherapeutic options available in the management of TRH. RECENT FINDINGS: Excess sodium and fluid retention, increased activation of the renin-angiotensin-aldosterone system, and heightened activity of the sympathetic nervous system appear to play an important role in development of TRH...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28586435/fetal-exposure-to-high-maternal-thyroid-hormone-th-levels-causes-central-resistance-to-th-in-adult-humans-and-mice
#10
Panudda Srichomkwun, João Anselmo, Xiao-Hui Liao, G Sebastian Hönes, Lars C Moeller, Manuela Alonso-Sampedro, Roy E Weiss, Alexandra M Dumitrescu, Samuel Refetoff
Context: Fetuses exposed to the high thyroid hormone (TH) levels of mothers with resistance to thyroid hormone beta (RTHβ), due to mutations in the THRB gene, have low birth weight and suppressed TSH. Objective: Determine if such exposure to high TH levels in embryonic life has a long-term effect into adulthood. Design: Observations in humans with a parallel design on animals to obtain a preliminary information regarding mechanism. Setting: University research centers...
June 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28557707/novel-mutation-t273r-in-thyroid-hormone-receptor-%C3%AE-gene-provides-further-insight-into-cryptic-negative-regulation-by-thyroid-hormone
#11
F Kaššák, V Hána, V Saudek, M Kostrouchová
Production of thyroid hormone is precisely regulated in a negative feed-back mechanism that depends critically on thyroid hormone receptor β (TRβ). This mechanism decreases production of thyrotropin- releasing hormone (TRH) and thyrotropin (TSH) in the hypothalamus and pituitary gland in response to high levels of circulating thyroid hormones (TH). Despite the wealth of accumulated knowledge, it is still not clear how exactly this negative regulation is executed. The syndrome of resistance to thyroid hormone (RTH), in which the levels of TH are not properly sensed, represents naturally occurring situations in which molecular components of this regulation are displayed and may be uncovered...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28556305/hypothalamic-dopamine-is-required-for-salsolinol-induced-prolactin-secretion-in-goats
#12
Tsutomu Hashizume, Ryunosuke Watanabe, Yuki Inaba, Ken Sawai, Ferenc Fülöp, György Miklos Nagy
The aim of the present study was to clarify the relationship between hypothalamic dopamine (DA) and salsolinol (SAL) for the secretion of prolactin (PRL) in goats. SAL or thyrotropin-releasing hormone (TRH) was intravenously injected into female goats treated with or without the D2 DA receptor antagonist haloperidol (Hal), which crosses the blood-brain barrier, and the PRL-releasing response to SAL was compared with that to TRH. PRL-releasing responses to SAL, Hal, and Hal plus SAL were also examined after a pretreatment to augment central DA using carbidopa (Carbi) and L-dopa...
May 29, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28531284/different-abundance-and-correlational-patterns-exist-between-total-and-presumed-pathogenic-vibrio-vulnificus-and-v-parahaemolyticus-in-shellfish-and-waters-along-the-north-carolina-coast
#13
Tiffany C Williams, Brett A Froelich, Britney Phippen, Patricia Fowler, Rachel T Noble, James D Oliver
Monitoring of Vibrio vulnificus and V. parahaemolyticus abundance is pertinent due to the ability of these species to cause disease in humans through aquatic vectors. Previously, we performed a multiyear investigation tracking Vibrio spp. levels in five sites along the southeastern North Carolina coast. From February 2013 to October 2015, total V. vulnificus and V. parahaemolyticus abundance was measured in water, oysters and clams. In the current study, pathogenic subpopulations were identified in these isolates using molecular markers, revealing that 5...
June 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28524176/lentivirus-mediated-microrna-124-gene-modified-bone-marrow-mesenchymal-stem-cell-transplantation-promotes-the-repair-of-spinal-cord-injury-in-rats
#14
Jia-Lin Song, Wei Zheng, Wei Chen, Yun Qian, Yuan-Ming Ouyang, Cun-Yi Fan
Our study aims to explore the effects of lentivirus-mediated microRNA-124 (miR-124) gene-modified bone marrow mesenchymal stem cell (BMSC) transplantation on the repair of spinal cord injury (SCI) in rats. BMSCs were isolated from the bone marrow of rats. The target gene miR-124 was identified using a luciferase-reporter gene assay. Seventy-two rats were selected for construction of the SCI model, and the rats were randomly divided into the blank group, sham group, SCI group, negative control (NC) group, overexpressed miR-124 group and si-PDXK group...
May 19, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28514180/molecular-typing-of-vibrio-parahaemolyticus-strains-isolated-from-mollusks-in-the-north-adriatic-sea
#15
Mohammad Shamsur Rahman, Roberta Carraro, Barbara Cardazzo, Lisa Carraro, Davide Boscolo Meneguolo, Maria Elena Martino, Nadia Andrea Andreani, Paola Bordin, Renzo Mioni, Lisa Barco, Enrico Novelli, Stefania Balzan, Luca Fasolato
BACKGROUND: Vibrio parahaemolyticus is an emerging foodborne pathogen in the Mediterranean, usually associated with shellfish consumption. The increase in the number of outbreaks in Europe is primarily associated with the global warming of the ocean that has a great impact on the spread and genetic selection of waterborne pathogens. The primary role of Italy in Europe's mollusk production, together with the fact that cases of infections with V. parahaemolyticus are not always notified to the European community, highlighted the necessity of acquiring new information about the epidemiological involvement of shellfish products...
May 17, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28504816/virulence-factors-and-antimicrobial-resistance-in-environmental-strains-of-vibrio-alginolyticus
#16
Marcos F Hernández-Robles, Ana K Álvarez-Contreras, Patricia Juárez-García, Iván Natividad-Bonifacio, Everardo Curiel-Quesada, Carlos Vázquez-Salinas, Elsa I Quiñones-Ramírez
Vibrio alginolyticus has acquired increasing importance because this microorganism may be pathogenic to aquatic animals and humans. It has been reported that some V. alginolyticus strains carry virulence genes derived from pathogenic V. cholerae and V. parahaemolyticus strains. In this work V. alginolyticus was isolated from oyster samples acquired from a food-market in Mexico City. Thirty isolates were identified as V. alginolitycus. Strains showed β-haemolysis and proteolytic activity and produced a capsule...
December 2016: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28482282/effects-of-ambient-exposure-refrigeration-and-icing-on-vibrio-vulnificus-and-vibrio-parahaemolyticus-abundances-in-oysters
#17
J L Jones, K A Lydon, T P Kinsey, B Friedman, M Curtis, R Schuster, J C Bowers
Vibrio vulnificus (Vv) and V. parahaemolyticus (Vp) illnesses are typically acquired through the consumption of raw molluscan shellfish, particularly oysters. As Vibrio spp. are naturally-occurring bacteria, one means of mitigation of illness is achieved by limiting post-harvest growth. In this study, effects of ambient air storage, refrigeration, and icing of oysters on Vibrio spp. abundances were examined at two sites in Alabama (AL) [Dog River (DR) and Cedar Point (CP)] and one site in Delaware Bay, New Jersey (NJ)...
April 27, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28463726/amitraz-changes-ne-da-and-5-ht-biosynthesis-and-metabolism-mediated-by-alterations-in-estradiol-content-in-cns-of-male-rats
#18
Javier Del Pino, Paula Moyano, Matilde Ruiz, María José Anadón, María Jesús Díaz, José Manuel García, Elena Labajo-González, María Teresa Frejo
Amitraz is a formamidine insecticide/acaricide that alters different neurotransmitters levels, among other neurotoxic effects. Oral amitraz exposure (20, 50 and 80 mg/kg bw, 5 days) has been reported to increase serotonin (5-HT), norepinephrine (NE) and dopamine (DA) content and to decrease their metabolites and turnover rates in the male rat brain, particularly in the striatum, prefrontal cortex, and hippocampus. However, the mechanisms by which these alterations are produced are not completely understood...
August 2017: Chemosphere
https://www.readbyqxmd.com/read/28461507/evolutionarily-conserved-trh-neuropeptide-pathway-regulates-growth-in-caenorhabditis-elegans
#19
Elien Van Sinay, Olivier Mirabeau, Geert Depuydt, Matthias Boris Van Hiel, Katleen Peymen, Jan Watteyne, Sven Zels, Liliane Schoofs, Isabel Beets
In vertebrates thyrotropin-releasing hormone (TRH) is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. However, a functional equivalent in protostomian animals remains unknown, although TRH receptors are conserved in proto- and deuterostomians. Here we identify a TRH-like neuropeptide precursor in Caenorhabditis elegans that belongs to a bilaterian family of TRH precursors. Using CRISPR/Cas9 and RNAi reverse genetics, we show that TRH-like neuropeptides, through the activation of their receptor TRHR-1, promote growth in Celegans TRH-like peptides from pharyngeal motor neurons are required for normal body size, and knockdown of their receptor in pharyngeal muscle cells reduces growth...
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28419241/central-hypothyroidism-due-to-a-trhr-mutation-causing-impaired-ligand-affinity-and-transactivation-of-gq
#20
Marta García, Jesús González de Buitrago, Mireia Jiménez-Rosés, Leonardo Pardo, Patricia M Hinkle, José C Moreno
Context: Central congenital hypothyroidism (CCH) is an underdiagnosed disorder characterized by deficient production and bioactivity of TSH leading to low thyroid hormone synthesis. TRH receptor (TRHR) defects are rare recessive disorders usually associated with incidentally identified CCH and short stature in childhood. Objectives: Clinical and genetic characterization of a consanguineous family of Roma origin with central hypothyroidism and identification of underlying molecular mechanisms...
April 17, 2017: Journal of Clinical Endocrinology and Metabolism
keyword
keyword
86998
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"