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https://www.readbyqxmd.com/read/29349834/drug-adherence-in-treatment-resistant-and-in-controlled-hypertension-results-from-the-swedish-primary-care-cardiovascular-database-spccd
#1
Lina Holmqvist, Kristina Bengtsson Boström, Thomas Kahan, Linus Schiöler, Miriam Qvarnström, Björn Wettermark, Per Hjerpe, Jan Hasselström, Karin Manhem
PURPOSE: To assess drug adherence in patients treated with ≥3 antihypertensive drug classes, with both controlled and uncontrolled blood pressure and describe associated factors for nonadherence. METHODS: Patients with hypertension, without cardiovascular comorbidity, aged >30 years treated with ≥3 antihypertensive drug classes were followed for 2 years. Both patients with treatment resistant hypertension (TRH) and patients with controlled hypertension were included...
January 19, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29343974/identification-of-key-pathways-and-genes-in-tp53-mutation-acute-myeloid-leukemia-evidence-from-bioinformatics-analysis
#2
Rui Huang, Xiwen Liao, Qiaochuan Li
Background: Tumor protein p53 (TP53) mutations are not only a risk factor in acute myeloid leukemia (AML) but also a potential biomarker for individualized treatment options. This study aimed to investigate potential pathways and genes associated with TP53 mutations in adult de novo AML. Methods: An RNA sequencing dataset of adult de novo AML was downloaded from The Cancer Genome Atlas database. Differentially expressed genes (DEGs) were identified by edgeR of the R platform...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29305326/neonatal-exposure-to-bisphenol-a-alters-the-hypothalamic-pituitary-thyroid-axis-in-female-rats
#3
Marina O Fernandez, Nadia S Bourguignon, Paula Arocena, Matías Rosa, Carlos Libertun, Victoria Lux-Lantos
Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Female Sprague-Dawley rats were injected sc from postnatal day 1 (PND1) to PND10 with BPA: 500 μg 50 μl-1 oil (B500), or 50 μg 50 μl-1 (B50), or 5 μg 50 μl-1 (B5). Controls were injected with 50 μl vehicle during the same period...
January 2, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29300135/non-clinical-pharmacokinetic-profiles-of-rovatirelin-an-orally-available-thyrotropin-releasing-hormone-analogue
#4
Kaoru Kobayashi, Yoshikazu Abe, Hiroshi Harada, Emiko Oota, Takuro Endo, Hiroo Takeda
The non-clinical pharmacokinetic profiles of rovatirelin, a novel thyrotropin releasing hormone (TRH) analogue, were investigated in vivo and in vitro. Rovatirelin orally administered to rats and dogs was rapidly absorbed and bioavailability was estimated to be 7.3% and 41.3%, respectively. The extent of plasma protein binding of rovatirelin in rats, dogs, and humans was low in all species (∼15%). The permeability of rovatirelin from blood to brain (permeability-surface area) ranged from 1.04 ± 0.14 to 1...
January 4, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29275437/gene-expression-of-thyrotropin-and-corticotrophin-releasing-hormones-is-regulated-by-environmental-salinity-in-the-euryhaline-teleost-sparus-aurata
#5
Ignacio Ruiz-Jarabo, J A Martos-Sitcha, C Barragán-Méndez, G Martínez-Rodríguez, J M Mancera, F J Arjona
In euryhaline teleosts, the hypothalamus-pituitary-thyroid and hypothalamus-pituitary-interrenal axes (HPT and HPI, respectively) are regulated in response to environmental stimuli such as salinity changes. However, the molecular players participating in this physiological process in the gilthead seabream (Sparus aurata), a species of high value for aquaculture, are still not identified and/or fully characterized in terms of gene expression regulation. In this sense, this study identifies and isolates the thyrotropin-releasing hormone (trh) mRNA sequence from S...
December 23, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29225205/effect-of-di-2-ethylhexyl-phthalate-on-the-hypothalamus-pituitary-thyroid-axis-in-adolescent-rat
#6
Di Sun, Liting Zhou, Shuyue Wang, Te Liu, Jian Zhu, Yiyang Jia, Jin Xu, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Lin Ye
Di-(2-ethylhexyl) phthalate (DEHP) is extensively used in many personal care and consumer products, which has resulted in widespread human exposure. Limited studies have suggested that exposure to DEHP may affect thyroid function, but little is known about the effect and mechanisms of DEHP exposure on the hypothalamic-pituitary-thyroid axis (HPTA). The present study was conducted to elucidate the potential mechanisms in which DEHP disrupts the function of the HPTA. Wistar rats were administered DEHP by gavage at 0, 5, 50, and 500 mg/kg/day for 28 days and then sacrificed within 24 h following the last dose...
December 9, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29195115/effect-of-dietary-carbohydrates-and-time-of-year-on-acth-and-cortisol-concentrations-in-adult-and-aged-horses
#7
S I Jacob, R J Geor, P S D Weber, P A Harris, M E McCue
Diagnosis of equine pituitary pars intermedia dysfunction (PPID) remains a challenge as multiple factors (stress, exercise, and time of year) influence ACTH and cortisol concentrations. To assess endocrine status in a study designed to evaluate the effects of age and diet on glucose and insulin dynamics, we performed thyrotropin-releasing hormone (TRH) stimulation tests and overnight dexamethasone suppression tests in March, May, August, and October on 16 healthy Thoroughbred and Standardbred mares and geldings...
November 1, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29185954/divalent-cations-increase-the-conjugation-efficiency-of-the-incompatibility-p-7-group-plasmid-pcar1-among-different-pseudomonas-hosts
#8
Ayako Sakuda, Chiho Suzuki-Minakuchi, Kazuhiro Matsui, Yurika Takahashi, Kazunori Okada, Hisakazu Yamane, Masaki Shintani, Hideaki Nojiri
The incompatibility (Inc) P-7 group plasmid pCAR1 can be efficiently transferred among bacteria in artificial microcosms in the presence of divalent cations Ca2+ and Mg2+. One-on-one mating assays between Pseudomonas strains with different plasmids showed that the promotion of conjugation efficiency by divalent cations was exhibited in other plasmids, including pB10 and NAH7; however, this effect was larger in IncP-7 plasmids. The impact on pCAR1 conjugation differed according to donor-recipient pairs, and conjugation efficiency promotion was clearly detected between the donors P...
November 29, 2017: Microbiology
https://www.readbyqxmd.com/read/29154715/virulence-and-antibiotic-resistance-of-vibrio-parahaemolyticus-isolates-from-seafood-from-three-developing-countries-and-of-worldwide-environmental-seafood-and-clinical-isolates-from-2000-to-2017
#9
Mohammad M Obaidat, Alaa E Bani Salman, Amira A Roess
Vibrio parahaemolyticus is a leading cause of seafood-associated illness. This study investigated the prevalence, virulence, and antibiotic resistance of V. parahaemolyticus in three low- and middle-income countries. Freshly caught fish samples (n = 330) imported to Jordan from Yemen, India, and Egypt were tested. The overall prevalence of V. parahaemolyticus was 15% (95% confidence interval: 11 to 19%). Three isolates (6%) were positive for the thermostable direct hemolysin-related (trh) gene, and all isolates was negative for the thermostable direct hemolysin (tdh) gene...
November 20, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29150510/characterization-of-vibrio-parahaemolyticus-and-vibrio-vulnificus-recovered-from-oysters-during-an-oyster-relay-study
#10
Sara Elmahdi, Salina Parveen, Sylvia Ossai, Ligia V DaSilva, Michael Jahncke, John Bowers, John Jacobs
Vibrio parahaemolyticus (Vp) and Vibrio vulnificus (Vv) are naturally occurring estuarine bacteria and are the leading causes of seafood-associated infections and mortality in the USA. Though multiple-antibiotic resistant Vp and Vv have been reported resistance patterns in vibrios are not as well documented as other food-borne bacterial pathogens. Salinity relaying (SR) is a Post-Harvest Processing (PHP) treatment to reduce the abundance of these pathogens in shellfish harvested during the warmer months. The purpose of this study was to evaluate the antimicrobial susceptibility (AMS), pathogenicity and genetic profiles of Vp and Vv recovered from oysters during an oyster relay study...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29142304/maternal-exposure-to-iodine-excess-throughout-pregnancy-and-lactation-induces-hypothyroidism-in-adult-male-rat-offspring
#11
Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Thiago Pantaleão, Vânia Maria Corrêa da Costa, Maria Tereza Nunes
This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Tsh expression and secretion in the adult male offspring. Moreover, the IE-exposed offspring rats presented reduced thyroid hormones levels, morphological alterations in the thyroid follicles, increased thyroid oxidative stress and decreased expression of thyroid differentiation markers (Tshr, Nis, Tg, Tpo, Mct8) and thyroid transcription factors (Nkx2...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137494/trh-receptor-mobility-in-the-plasma-membrane-is-strongly-affected-by-agonist-binding-and-by-interaction-with-some-cognate-signaling-proteins
#12
Radka Moravcova, Barbora Melkes, Jiri Novotny
OBJECTIVES: Extensive research has been dedicated to elucidating the mechanisms of signal transduction through different G protein-coupled receptors (GPCRs). However, relatively little is known about the regulation of receptor movement within the cell membrane upon ligand binding. In this study we focused our attention on the thyrotropin-releasing hormone (TRH) receptor that typically couples to Gq/11 proteins. METHODS: We monitored receptor diffusion in the plasma membrane of HEK293 cells stably expressing yellow fluorescent protein (YFP)-tagged TRH receptor (TRHR-YFP) by fluorescence recovery after photobleaching (FRAP)...
November 14, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29124350/role-of-trh-ucn3-neurons-of-the-perifornical-area-bed-nucleus-of-stria-terminalis-region-in-the-regulation-of-the-anorexigenic-pomc-neurons-of-the-arcuate-nucleus-in-male-mice-and-rats
#13
Zoltán Péterfi, Erzsébet Farkas, Kata Nagyunyomi-Sényi, Andrea Kádár, Szenci Ottó, András Horváth, Tamás Füzesi, Ronald M Lechan, Csaba Fekete
Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In this study, therefore, we tested the hypothesis that the TRH/UCN3 neurons regulate food intake by influencing feeding-related neuropeptide Y (NPY) and/or proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC)...
November 9, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29102876/maternal-high-fat-diet-induces-sex-specific-endocannabinoid-system-changes-in-newborn-rats-and-programs-adiposity-energy-expenditure-and-food-preference-in-adulthood
#14
Camilla P Dias-Rocha, Mariana M Almeida, Erika M Santana, Julia C B Costa, Juliana G Franco, Carmen C Pazos-Moura, Isis H Trevenzoli
Early life inadequate nutrition triggers developmental adaptations and adult chronic disease. Maternal high-fat (HF) diet promotes visceral obesity and hypothalamic leptin resistance in male rat offspring at weaning and adulthood. Obesity is related to over active endocannabinoid system (ECS). The ECS consists mainly of endogenous ligands, cannabinoid receptors (CB1 and CB2), and the enzymes fatty acid anandamide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). We hypothesized that perinatal maternal HF diet would regulate offspring ECS in hypothalamus and brown adipose tissue (BAT) at birth, prior to visceral obesity development, and program food preference and energy expenditure of adult offspring...
October 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29099999/high-fat-simple-carbohydrate-diet-intake-induces-hypothalamic-pituitary-thyroid-axis-dysregulation-in-c57bl-6j-male-mice
#15
Swarnalatha Banavara Nagaraj, Neena Roy, Mahesh Manjunath Gouda, Rajeish Moger, Asha Abraham
Given the association between subclinical hypothyroidism and metabolic syndrome (MetS), we wanted to explore if high fat simple carbohydrate (HFSC) diet affect hypothalamus-pituitary-thyroid axis. One month old male C57BL/6J mice were fed with Control (C) and HFSC (T) feed (n=18 each) respectively for 5 months. T3 showed a significant increase in T(13.5%) compared to age matched C by 5th month.TSH was significantly high (1mo:1.9fold; 3mo:2.66 fold; 5mo:3.5fold) from 1stmonth to 5thmonth in T compared to age matched C...
November 3, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29080422/development-of-a-rapid-immunochromatographic-assay-to-detect-contamination-of-raw-oysters-with-enteropathogenic-vibrio-parahaemolyticus
#16
Junko Sakata, Taro Yonekita, Kentaro Kawatsu
Thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) are major virulence factors of enteropathogenic Vibrio parahaemolyticus. TDH and TRH are bacterial exotoxins, and their presence in culture medium serves as a specific marker for detecting this significant pathogen. Here, we developed and evaluated an immunochromatographic assay (TDH/TRH-ICA) to simultaneously or individually detect TDH and TRH. The TDH/TRH-ICA detected TDH in all broth cultures of 47 V. parahaemolyticus strains carrying tdh...
October 14, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29064607/hypothalamic-pituitary-thyroid-hpt-axis-functioning-in-anxiety-disorders-a-systematic-review
#17
REVIEW
Susanne Fischer, Ulrike Ehlert
Depression has repeatedly been linked to subclinical hypothyroidism, and thyroid hormones have successfully been used to augment antidepressant treatment. By contrast, the extent of thyroid dysfunction in anxiety disorders remains less clear. This is surprising, given that anxiety-related symptoms (e.g., nervousness, palpitations, increased perspiration) are highly prevalent in hyperthyroidism. The present study was undertaken to synthesize the literature on hypothalamic-pituitary-thyroid (HPT) axis functioning in anxiety disorders...
October 24, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29057835/intrauterine-zn-deficiency-favors-thyrotropin-releasing-hormone-increasing-effects-on-thyrotropin-serum-levels-and-induces-subclinical-hypothyroidism-in-weaned-rats
#18
Viridiana Alcántara-Alonso, Elena Alvarez-Salas, Gilberto Matamoros-Trejo, Patricia de Gortari
Individuals who consume a diet deficient in zinc (Zn-deficient) develop alterations in hypothalamic-pituitary-thyroid axis function, i.e., a low metabolic rate and cold insensitivity. Although those disturbances are related to primary hypothyroidism, intrauterine or postnatal Zn-deficient adults have an increased thyrotropin (TSH) concentration, but unchanged thyroid hormone (TH) levels and decreased body weight. This does not support the view that the hypothyroidism develops due to a low Zn intake. In addition, intrauterine or postnatal Zn-deficiency in weaned and adult rats reduces the activity of pyroglutamyl aminopeptidase II (PPII) in the medial-basal hypothalamus (MBH)...
October 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29042091/effects-of-renal-denervation-on-coronary-flow-reserve-and-forearm-dilation-capacity-in-patients-with-treatment-resistant-hypertension-a-randomized-double-blinded-sham-controlled-clinical-trial
#19
Morten Engholm, Jannik B Bertelsen, Ole N Mathiassen, Hans E Bøtker, Henrik Vase, Christian D Peters, Jesper N Bech, Niels H Buus, Anne P Schroeder, Hans Rickers, Klavs W Hansen, Per L Poulsen, Anne Kaltoft, Kent L Christensen
BACKGROUND: Microvascular impairment is well documented in hypertension. We investigated the effect of renal sympathetic denervation (RDN) on cardiac and peripheral microvasculature in patients with treatment-resistant essential hypertension (TRH). METHODS: A randomized, single centre, double-blinded, sham-controlled clinical trial. Fifty-eight patients with TRH (ambulatory systolic BP (ASBP) ≥ 145mmHg) despite stable treatment were randomized to RDN or SHAM. RDN was performed with the unipolar Medtronic Flex catheter...
October 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29039708/detection-of-total-and-pathogenic-vibrio-parahaemolyticus-in-shellfish-growing-along-the-south-yellow-sea-and-the-east-china-sea
#20
Feng Han, Run-Run Gu, Xiao-Sheng Shen, Yuan-Ge Chen, Liang-Liang Tian, Wei-Feng Zhou, You-Qiong Cai
This study was conducted to monitor the densities of total and pathogenic Vibrio parahaemolyticus in 300 samples of nine shellfish species harvested from the coasts of the South Yellow Sea and the East China Sea (N 23° to 34°, E 116° to 124°), People's Republic of China, between May and October 2015. Total V. parahaemolyticus densities were measured, and V. parahaemolyticus isolates were biochemically identified with probes for the thermostable direct hemolysin gene (tdh) and the thermostable direct hemolysin-related hemolysin gene (trh)...
October 17, 2017: Journal of Food Protection
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