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https://www.readbyqxmd.com/read/28211216/low-dose-eplerenone-treatment-decreases-aortic-stiffness-in-patients-with-resistant-hypertension
#1
Tatjana Kalizki, Bernhard M W Schmidt, Ulrike Raff, Annemarie Reinold, Thomas K Schwarz, Markus P Schneider, Roland E Schmieder, Andreas Schneider
Vascular damage is aggravated in animal models of hypertension with mineralocorticoid (MR) excess and in hypertensive patients with primary hyperaldosteronism. MR antagonism has shown to provide effective blood pressure (BP)-control in patients with treatment resistant hypertension (TRH), but the concurrent effects on the vasculature have not been examined. In a randomized, double-blinded, placebo-controlled parallel-group study, 51 patients with TRH received either eplerenone 50 mg or placebo for 6 months together with additional antihypertensives titrated to achieve a BP target of <140/90 mm Hg...
February 17, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28199771/thyroid-dysfunction-in-children-with-autism-spectrum-disorder-is-associated-with-folate-receptor-alpha-autoimmune-disorder
#2
Richard E Frye, Rebecca Wynne, Shannon Rose, John Slattery, Leanna Delhey, Marie Tippett, Stephen G Kahler, Sirish C Bennuri, Stepan Melnyk, Jeffrey M Sequeira, Edward Quadros
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in Autism Spectrum Disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. We measured blocking and binding FRAAs and thyroid stimulating hormone (TSH), free T4 (FT4), total T3 (TT3), reverse T3 (rT3), thyroid releasing hormone (TRH) and other metabolites in 87 children with ASD, 84 of whom also underwent behavior and cognition testing and in 42 of whom FRAAs, TSH and FT4 were measured at two time points...
February 15, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28173961/a-screen-for-modulators-reveals-that-orexin-a-rapidly-stimulates-thyrotropin-releasing-hormone-expression-and-release-in-hypothalamic-cell-culture
#3
Antonieta Cote-Vélez, Anabel Martínez Báez, Leticia Lezama, Rosa María Uribe, Patricia Joseph-Bravo, Jean-Louis Charli
In the paraventricular nucleus of the mammalian hypothalamus, hypophysiotropic thyrotropin releasing hormone (TRH) neurons integrate metabolic information and control the activity of the thyroid axis. Additional populations of TRH neurons reside in various hypothalamic areas, with poorly defined connections and functions, albeit there is evidence that some may be related to energy balance. To establish extracellular modulators of TRH hypothalamic neurons activity, we performed a screen of neurotransmitters effects in hypothalamic cultures...
February 2, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28144705/ecological-fitness-and-virulence-features-of-vibrio-parahaemolyticus-in-estuarine-environments
#4
REVIEW
Charles R Lovell
Vibrio parahaemolyticus is a commonly encountered and highly successful organism in marine ecosystems. It is a fast-growing, extremely versatile copiotroph that is active over a very broad range of conditions. It frequently occurs suspended in the water column (often attached to particles or zooplankton), and is a proficient colonist of submerged surfaces. This organism is an important pathogen of animals ranging from microcrustaceans to humans and is a causative agent of seafood-associated food poisoning. This review examines specific ecological adaptations of V...
January 31, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28118280/low-dose-eplerenone-decreases-left-ventricular-mass-in-treatment-resistant-hypertension
#5
Andreas Schneider, Johannes Schwab, Marina V Karg, Tatjana Kalizki, Annemarie Reinold, Ingrid Bär, Markus P Schneider, Roland E Schmieder, Bernhard M W Schmidt
BACKGROUND: Mineralocorticoid receptor antagonists are increasingly used in patients with treatment-resistant hypertension (TRH). There is experimental evidence for blood pressure (BP) independent effects of mineralocorticoid receptor blockade on cardiovascular target organ damage. We hypothesized that low-dose eplerenone (50 mg) will reduce left ventricular mass (LVM) beyond its BP-lowering effects. METHODS: We performed a randomized, double-blind, placebo-controlled, parallel group study in 51 patients with TRH...
January 23, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28099500/genetic-analysis-of-vibrio-parahaemolyticus-o3-k6-strains-that-have-been-isolated-in-mexico-since-1998
#6
Abraham Guerrero, Marcial Leonardo Lizárraga-Partida, Bruno Gómez Gil Rodríguez, Alexei Fedorovish Licea-Navarro, Valeria Jeanette Revilla-Castellanos, Irma Wong-Chang, Ricardo González-Sánchez
Vibrio parahaemolyticus is an important human pathogen that has been isolated worldwide from clinical cases, most of which have been associated with seafood consumption. Environmental and clinical toxigenic strains of V. parahaemolyticus that were isolated in Mexico from 1998 to 2012, including those from the only outbreak that has been reported in this country, were characterized genetically to assess the presence of the O3:K6 pandemic clone, and their genetic relationship to strains that are related to the pandemic clonal complex (CC3)...
2017: PloS One
https://www.readbyqxmd.com/read/28087532/establishment-and-validation-of-rna-based-predictive-models-for-understanding-survival-of-vibrio-parahaemolyticus-in-oysters-stored-at-low-temperatures
#7
Chao Liao, Yong Zhao, Luxin Wang
: This study developed RNA-based predictive models describing the survival of Vibrio parahaemolyticus in Eastern oysters (Crassostrea virginica) during storage at 0, 4, and 10°C. Post-harvested oysters were inoculated with a cocktail of five V. parahaemolyticus strains and were then stored at 0, 4, and 10°C for 21 or 11 days. A real-time RT-PCR assay targeting expression of tlh gene was used to evaluate the number of surviving V. parahaemolyticus, which was then used to establish primary molecular models (MMs)...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28073082/vibrio-parahaemolyticus-o4-k8-forms-a-potential-predominant-clone-in-southern-china-as-detected-by-whole-genome-sequence-analysis
#8
Baisheng Li, Xingfen Yang, Hailing Tan, Bixia Ke, Dongmei He, Changwen Ke, Yonghui Zhang
Vibrio parahaemolyticus has been the most common food-borne pathogen in southern China, especially the O3:K6 pandemic clone and its serovariants. Recently, the serotype O4:K8 became more and more prevalent in southern China, which was different from the O3:K6 pandemic clone. Thus, the aim of the present work was to elucidate the molecular characteristics of the O4:K8. Some O3:K6 pandemic clone and its serovariants isolated in the same period were selected for comparative analysis, which were still dominant clone locally...
March 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28065941/di2-ethylhexyl-phthalate-disrupts-thyroid-hormone-homeostasis-through-activating-the-ras-akt-trhr-pathway-and-inducing-hepatic-enzymes
#9
Hanfeng Ye, Mei Ha, Min Yang, Ping Yue, Zhengyuan Xie, Changjiang Liu
Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats were dosed with DEHP by gavage for 30 consecutive days; Nthy-ori 3-1 cells were treated with DEHP with NAC, k-Ras siRNA or inhibitors (U0126 and wortmannin). Results showed that DEHP led to histopathologic changes in rat thyroid and liver, such as the decrease in thyroid follicular cavity diameter, hepatocyte edema...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28063130/glucocorticoids-curtail-stimuli-induced-creb-phosphorylation-in-trh-neurons-through-interaction-of-the-glucocorticoid-receptor-with-the-catalytic-subunit-of-protein-kinase-a
#10
Israim Sotelo-Rivera, Antonieta Cote-Vélez, Rosa-María Uribe, Jean-Louis Charli, Patricia Joseph-Bravo
PURPOSE: Corticosterone prevents cold-induced stimulation of thyrotropin-releasing hormone (Trh) expression in rats, and the stimulatory effect of dibutyryl cyclic-adenosine monophosphate (dB-cAMP) on Trh transcription in hypothalamic cultures. We searched for the mechanism of this interference. METHODS: Immunohistochemical analyses of phosphorylated cAMP-response element binding protein (pCREB) were performed in the paraventricular nucleus (PVN) of Wistar rats, and in cell cultures of 17-day old rat hypothalami, or neuroblastoma SH-SY5Y cells...
January 6, 2017: Endocrine
https://www.readbyqxmd.com/read/28058248/first-multi-year-retrospective-study-on-vibrio-parhaemolyticus-and-vibrio-vulnificus-prevalence-in-ruditapes-philippinarum-harvested-in-sacca-di-goro-italy
#11
Patrizia Serratore, Fabio Ostanello, Pier Luca Passalacqua, Emanuele Zavatta, Giorgia Bignami, Andrea Serraino, Federica Giacometti
The present work describes a retrospective study aiming to verify a possible correlation between the environmental conditions (temperature, salinity and dissolved oxygen), the abundance of Vibrio spp., and the prevalence of V. parahaemolyticus and V. vulnificus in the Manila clam R. philippinarum harvested in Sacca di Goro, Emilia-Romagna Region, Northern Italy. On the whole, 104 samples, collected in the period 2007-2015 and submitted to microbiological analyses (isolation and genotyping), have been reconsidered for Vibrio spp...
September 20, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27891183/complete-genome-of-vibrio-parahaemolyticus-forc014-isolated-from-the-toothfish
#12
Sojin Ahn, Han Young Chung, Sooyeon Lim, Kwondo Kim, Suyeon Kim, Eun Jung Na, Kelsey Caetano-Anolles, Ju-Hoon Lee, Sangryeol Ryu, Sang Ho Choi, Heebal Kim
BACKGROUND: Foodborne illness can occur due to various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli and Vibrio parahaemolyticus, and can cause severe gastroenteritis symptoms. In this study, we completed the genome sequence of a foodborne pathogen V. parahaemolyticus FORC_014, which was isolated from suspected contaminated toothfish from South Korea. Additionally, we extended our knowledge of genomic characteristics of the FORC_014 strain through comparative analysis using the complete sequences of other V...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27882133/effects-of-forced-swimming-stress-on-thyroid-function-pituitary-thyroid-stimulating-hormone-and-hypothalamus-thyrotropin-releasing-hormone-expression-in-adrenalectomy-wistar-rats
#13
Qiuyan Sun, Aihua Liu, Yanan Ma, Anyi Wang, Xinhong Guo, Weiping Teng, Yaqiu Jiang
In order to study the impact that is imposed on the hypothalamic-pituitary-thyroid (HPT) axis of adrenalectomy male Wistar rats by stress caused by swimming, the blood level of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH), the expression of TSHβ mRNA at the pituitary and thyrotropin releasing hormone (TRH) expression at the paraventricular nucleus (PVN) were measured. A total of 50 male Wistar rats of 6-8 weeks of age and with an average weight of 190-210 grams were randomly divided into the following two groups: The surgical (without adrenal glands) and non-surgical (adrenalectomy) group...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27864049/phosphodiesterase-7-inhibition-affects-accumbal-and-hypothalamic-thyrotropin-releasing-hormone-expression-feeding-and-anxiety-behavior-of-rats
#14
M I Valdés-Moreno, V Alcántara-Alonso, E Estrada-Camarena, G Mengod, M I Amaya, G Matamoros-Trejo, P de Gortari
Thyrotropin-releasing hormone (TRH) has anorexigenic and anxiolytic functions when injected intraventricularly. Nucleus accumbens (NAcc) is a possible brain region involved, since it expresses proTRH. TRH from hypothalamic paraventricular nucleus (PVN) has a food intake-regulating role. TRHergic pathways of NAcc and PVN are implicated in anxiety and feeding. Both behaviors depend on cAMP and phosphorylated-cAMP response element binding protein (pCREB) intracellular levels. Intracellular levels of cAMP are controlled by the degrading activity of phosphodiesterases (PDEs)...
February 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27836844/season-specific-occurrence-of-potentially-pathogenic-vibrio-spp-on-the-southern-coast-of-south-korea
#15
Doris Y W Di, Anna Lee, Jeonghwan Jang, Dukki Han, Hor-Gil Hur
: Vibrio species are widely distributed in warm estuarine and coastal environments, and they can infect humans through the consumption of raw and mishandled contaminated seafood. In this study, we aimed to isolate and observe the distribution of enteropathogenic Vibrio spp. from environments of the southern coast of South Korea over a season cycle. A total of 10,983 isolates of Vibrio spp. were obtained from tidal water and mud samples over a 1-year period from five sampling sites along the southwest coast of South Korea...
February 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27836764/direct-detection-of-various-pathogens-by-loop-mediated-isothermal-amplification-assays-on-bacterial-culture-and-bacterial-colony
#16
Muxia Yan, Weidong Li, Zhenwen Zhou, Hongxia Peng, Ziyan Luo, Ling Xu
In this work, loop-mediated isothermal amplification based detection assay using bacterial culture and bacterial colony for various common pathogens direct detection had been established, evaluated and further applied. A total of five species of common pathogens and nine detection targets (tlh, tdh and trh for V. Parahaemolyticus, rfbE, stx1 and stx2 for E. coli, oprI for P. aeruginosa, invA for Salmonella and hylA for L. monocytogenes) were performed on bacterial culture and bacterial colony LAMP. To evaluate and optimize this assay, a total of 116 standard strains were included...
January 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27827805/the-hot-oyster-levels-of-virulent-vibrio-parahaemolyticus-strains-in-individual-oysters
#17
Savannah L Klein, Charles R Lovell
Vibrio parahaemolyticus is the leading cause of seafood-associated gastroenteritis and is most commonly transmitted by raw oysters. Consequently, detection of virulent strains of this organism in oysters is a primary concern for seafood safety. Vibrio parahaemolyticus levels were determined in 110 individual oysters harvested from two sampling sites in SC, USA. The majority of oysters (98%) contained low levels of presumptive V. parahaemolyticus However, two healthy oysters contained presumptive V. parahaemolyticus numbers that were unusually high...
February 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27815747/first-series-of-total-robotic-hysterectomy-trh-using-new-integrated-table-motion-for-the-da-vinci-xi-feasibility-safety-and-efficacy
#18
Andrea Giannini, Eleonora Russo, Paolo Mannella, Giulia Palla, Silvia Pisaneschi, Elena Cecchi, Michele Maremmani, Luca Morelli, Alessandra Perutelli, Vito Cela, Franca Melfi, Tommaso Simoncini
BACKGROUND: To present the first case series of total robotic hysterectomy (TRH), using integrated table motion (ITM), which is a new feature comprising a unique operating table by Trumpf Medical that communicates wirelessly with the da Vinci Xi surgical system. ITM has been specifically developed to improve multiquadrant robotic surgery such as that conducted in colorectal surgery. METHODS: Between May and October 2015, a prospective post-market study was conducted on ITM in the EU in 40 cases from different specialties...
November 4, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27810782/effect-of-l-pglu-1-benzyl-l-his-l-pro-nh2-against-in-vitro-and-in-vivo-models-of-cerebral-ischemia-and-associated-neurological-disorders
#19
Satyendra K Rajput, Arun K Sharma, Chhuttan L Meena, Aditya B Pant, Rahul Jain, Shyam S Sharma
Central nervous system plays a vital role in regulation of most of biological functions which are abnormally affected in various disorders including cerebral ischemia, Alzheimer's and Parkinson's (AD and PD) worldwide. Cerebral stroke is an extremely fatal and one of the least comprehensible neurological disorders due to limited availability of prospective clinical approaches and therapeutics. Since, some endogenous peptides like thyrotropin-releasing hormone have shown substantial neuroprotective potential, hence present study evaluates the newer thyrotropin-releasing hormone (TRH) analogue L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 for its neuroprotective effects against oxygen glucose deprivation (OGD), glutamate and H2O2 induced injury in pheochromocytoma cell lines (PC-12 cells) and in-vivo ischemic injury in mice...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27809680/in-vivo-functional-consequences-of-human-thra-variants-expressed-in-the-zebrafish
#20
Federica Marelli, Silvia Carra, Giuditta Rurale, Franco Cotelli, Luca Persani
BACKGROUND: Heterozygous mutations in the thyroid hormone receptor alpha (THRA) gene cause resistance to thyroid hormone alpha (RTHα), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyrotropin levels. It was recently described that zebrafish embryos expressing a dominant negative (DN) form of thraa recapitulate the key features of RTHα, and that zebrafish and human receptors are functionally interchangeable...
February 2017: Thyroid: Official Journal of the American Thyroid Association
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