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https://www.readbyqxmd.com/read/29751401/exposure-to-pfdoa-causes-disruption-of-the-hypothalamus-pituitary-thyroid-axis-in-zebrafish-larvae
#1
Shengnan Zhang, Xiaochun Guo, Shaoyong Lu, Nan Sang, Guangyu Li, Ping Xie, Chunsheng Liu, Liguo Zhang, Yi Xing
Perfluorododecanoic acid (PFDoA), a kind of perfluorinated carboxylic acid (PFCA) with 12 carbon atoms, has an extensive industrial utilization and is widespread in both wildlife and the water environment, and was reported to have the potential to cause a disruption in the thyroid hormone system homeostasis. In this study, zebrafish embryos/larvae were exposed to different concentrations of PFDoA (0, 0.24, 1.2, 6 mg/L) for 96 h post-fertilization (hpf). PFDoA exposure caused obvious growth restriction connected with the reduced thyroid hormones (THs) contents in zebrafish larvae, strengthening the interference effect on the growth of fish larvae...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29739776/prevalence-of-treatment-resistant-hypertension-after-considering-pseudo-resistance-and-morbidity-a-cross-sectional-study-in-irish-primary-care
#2
Peter Hayes, Monica Casey, Liam G Glynn, Gerard J Molloy, Hannah Durand, Eoin O'Brien, Eamon Dolan, John Newell, Andrew W Murphy
BACKGROUND: To confirm treatment-resistant hypertension (TRH), ambulatory blood pressure measurement (ABPM) must exclude white-coat hypertension (WCH), three or more medications should be prescribed at the optimal doses tolerated, and non-adherence and lifestyle should be examined. Most previous studies have not adequately considered pseudo-resistance and merely provide an apparent TRH (aTRH) prevalence figure. AIM: To conduct a cross-sectional study of the prevalence of aTRH in general practice, and then consider pseudo-resistance and morbidity...
May 8, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29736988/use-of-basal-and-trh-stimulated-plasma-growth-hormone-concentrations-to-differentiate-between-primary-hypothyroidism-and-nonthyroidal-illness-in-dogs
#3
Tera Pijnacker, Hans S Kooistra, Cathelijne F Vermeulen, Merel van der Vinne, Marrit Prins, Sara Galac, Jan A Mol
BACKGROUND: A low plasma total thyroxine (TT4 ) concentration in combination with a plasma TSH concentration within reference range does not distinguish between hypothyroidism and nonthyroidal illness (NTI) in dogs. Hypothyroidism is associated with TSH-releasing hormone (TRH)-induced increased release of growth hormone (GH). HYPOTHESIS: Basal and TRH-induced plasma GH concentrations can be used to distinguish hypothyroid dogs from NTI dogs. ANIMALS: Twenty-one dogs with signs consistent with hypothyroidism, a low plasma TT4 concentration, and a plasma TSH concentration within reference interval...
May 7, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29724865/effects-of-intravenous-thyrotropin-releasing-hormone-on-18f-fluorodeoxyglucose-uptake-in-human-brown-adipose-tissue-a-randomized-controlled-trial
#4
Charlotte A Heinen, Zhi Zhang, Lars P Klieverik, Tim C de Wit, Edwin Poel, Maqsood Yaqub, Anita Boelen, Andries Kalsbeek, Peter H Bisschop, Paul van Trotsenburg, Hein Verberne, Jan Booij, Eric Fliers
OBJECTIVE: Brown adipose tissue (BAT) activity in humans is stimulated by cold and by a limited number of pharmacological agents, including β3-adrenergic agonists and bile acids. Although thyrotropin-releasing hormone (TRH) is known to activate BAT in several mammals, this has not been reported in humans. DESIGN: A randomized, placebo-controlled, double blind, cross-over trial. METHODS: We investigated the effects of intravenous bolus administration of 400 µg TRH or 2 mL saline on BAT activity in healthy, lean men...
May 3, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29706341/evaluation-of-short-purification-cycles-in-naturally-contaminated-mediterranean-mussels-mytilus-galloprovincialis-harvested-in-sardinia-italy
#5
Giovanni Sferlazzo, Domenico Meloni, Sonia Lamon, Marta Marceddu, Anna Mureddu, Simonetta Gianna Consolati, Margherita Pisanu, Sebastiano Virgilio
The aim of the present study was to investigate the effect of short purification cycles on the safety of naturally contaminated Mytilus galloprovincialis from harvesting areas of the Gulf of Olbia (Sardinia, Italy). Samples from ten batches of mussels were collected before, during and after purification treatment at two purification centres (A-B). All the samples were analysed for Escherichia coli and Salmonella spp according to Council Regulation (EC) 2285/2015. Detection and enumeration of Vibrio spp were performed according to previously published methods...
September 2018: Food Microbiology
https://www.readbyqxmd.com/read/29695647/a-case-of-tsh-secreting-pituitary-adenoma-with-cyclic-fluctuations-in-serum-tsh-levels
#6
Hideyuki Okuma, Koshi Hashimoto, Takuya Ohashi, Masatomo Mihara, Isao Minami, Hajime Izumiyama, Shigekazu Sasaki, Naoko Inoshita, Hiroshi Nishioka, Shozo Yamada, Takanobu Yoshimoto
A 29-year-old man was referred to our department due to adrenal insufficiency with the inappropriate secretion of TSH (SITSH). Magnetic resonance imaging revealed a pituitary tumor. A weak TSH response in the TRH test, elevated sex hormone binding globulin (SHBG) levels, and the absence of a family medical history of SITSH or TRβ gene mutations supported the diagnosis of TSH-secreting pituitary adenoma (TSHoma). However, complete TSH suppression and a blunted cholesterol response in the T3 suppression test as well as normal glycoprotein α-subunit (α-GSU) levels were not compatible with TSHoma...
April 26, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29693365/identification-of-key-candidate-genes-and-pathways-in-endometrial-cancer-by-integrated-bioinformatical-analysis
#7
Lihong Liu, Fangxu Chen, Aihui Xiu, Bo Du, Hao Ai, Wei Xie
Endometrial Cancer is the most common female genital tract malignancy, its pathogenesis is complex, not yet fully described. To identify key genes of Endometrial Cancer we downloaded the gene chip GSE17025 from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified through the GEO2R analysis tool. Functional and pathway enrichment analysis were performed for DEGs using DAVID database. The network of protein–protein-interaction (PPI) was established by STRING website and visualized by Cytoscape...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29674333/intravenous-and-intratracheal-thyrotropin-releasing-hormone-and-its-analog-taltirelin-reverse-opioid-induced-respiratory-depression-in-isoflurane-anesthetized-rats
#8
James D Boghosian, Anita Luethy, Joseph F Cotten
Thyrotropin releasing hormone (TRH) is a tripeptide hormone and a neurotransmitter widely-expressed in the CNS that regulates thyroid function and that maintains physiologic homeostasis. Following injection in rodents, TRH has multiple effects including increased blood pressure and breathing. We tested the hypothesis that TRH and its long-acting analog, taltirelin, will reverse morphine-induced respiratory depression in anesthetized rats following intravenous(IV) or intratracheal(IT) administration. TRH (1 mg/kg plus 5 mg/kg/hour IV) and talitrelin (1 mg/kg IV), when administered to rats pretreated with morphine (5 mg/kg IV), increased ventilation from 50±6 to 131±7% and 45±6 to 168±13% (percent baseline; n=4±SEM), primarily through increased breathing rates (from 76+/-9 to 260±14% and 66±8 to 318±37%)...
April 19, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29660579/the-effect-of-dermal-benzophenone-2-administration-on-immune-system-activity-hypothalamic-pituitary-thyroid-axis-activity-and-hematological-parameters-in-male-wistar-rats
#9
Żaneta Broniowska, Joanna Ślusarczyk, Beata Starek-Świechowicz, Ewa Trojan, Bartosz Pomierny, Weronika Krzyżanowska, Agnieszka Basta-Kaim, Bogusława Budziszewska
Benzophenones used as UV filters, in addition to the effects on the skin, can be absorbed into the blood and affect the function of certain organs. So far, their effects on the sex hormone receptors and gonadal function have been studied, but not much is known about their potential action on other systems. The aim of the present study was to determine the effect of benzophenone-2 (BP-2) on immune system activity, hypothalamic-pituitary-thyroid (HPT) axis activity and hematological parameters. BP-2 was administered dermally, twice daily at a dose of 100 mg/kg for 4-weeks to male Wistar rats...
April 13, 2018: Toxicology
https://www.readbyqxmd.com/read/29642854/comparative-transcriptome-analysis-of-hypothalamus-regulated-feed-intake-induced-by-exogenous-visfatin-in-chicks
#10
Zhuanjian Li, Xuelian Liu, Panpan Zhang, Ruili Han, Guirong Sun, Ruirui Jiang, Yanbin Wang, Xiaojun Liu, Wenya Li, Xiangtao Kang, Yadong Tian
BACKGROUND: The intracerebroventricular injection of visfatin increases feed intake. However, little is known about the molecular mechanism in chicks. This study was conducted to assess the effect of visfatin on the feeding behavior of chicks and the associated molecular mechanism. RESULTS: In response to the intraventricular injection of 40 ng and 400 ng visfatin, feed intake in chicks was significantly increased, and the concentrations of glucose, insulin, TG, HDL and LDL were significantly altered...
April 11, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29622766/olfactory-marker-protein-regulates-prolactin-secretion-and-production-by-modulating-ca-2-and-trh-signaling-in-lactotrophs
#11
Chan Woo Kang, Ye Eon Han, Mi Kyung Lee, Yoon Hee Cho, NaNa Kang, JaeHyung Koo, Cheol Ryong Ku, Eun Jig Lee
Olfactory marker protein (OMP) is a marker of olfactory receptor-mediated chemoreception, even outside the olfactory system. Here, we report that OMP expression in the pituitary gland plays a role in basal and thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) production and secretion. We found that OMP was expressed in human and rodent pituitary glands, especially in PRL-secreting lactotrophs. OMP knockdown in GH4 rat pituitary cells increased PRL production and secretion via extracellular signal-regulated kinase (ERK)1/2 signaling...
April 6, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29608445/hiv-testing-with-and-without-a-clinical-consultation-among-men-who-have-sex-with-men-a-randomised-controlled-trial
#12
Trh Read, S Walker, Epf Chow, J J Ong, C S Bradshaw, N A Medland, R Wigan, M Y Chen, C K Fairley
BACKGROUND: Increasing the frequency of HIV testing among men who have sex with men (MSM), maximises the preventive effect of antiretroviral therapy, by reducing time to diagnosis and treatment. SETTING: Melbourne Sexual Health Centre, Australia. METHODS: This randomised controlled trial evaluated whether access to testing,without seeing a clinician, would increase testing frequency. MSM attending for HIV testing between July 2014 and April 2015 were randomised 1:1 to the intervention (access to HIV and syphilis testing at 300 pathology centres, without requiring consultations) or the control arm (consultation at every test), without blinding...
March 29, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29601411/antihypertensive-drug-use-in-resistant-and-nonresistant-hypertension-and-in-controlled-and-uncontrolled-resistant-hypertension
#13
Alejandro de la Sierra, Pedro Armario, Anna Oliveras, José R Banegas, Manuel Gorostidi, Ernest Vinyoles, Juan J de la Cruz, Julián Segura, Luis M Ruilope
BACKGROUND AND AIM: Treatment-resistant hypertension (TRH) is associated with particular clinical features, nonadherence, and suboptimal treatment. We assessed possible associations of antihypertensive drug classes, specific agents inside each class, and types of combinations, with the presence of non-TRH vs. TRH, and with controlled vs. uncontrolled TRH. METHODS: Comparisons were done in 14 264 patients treated with three drugs (non-TRH: 2988; TRH: 11 276) and in 6974 treated with at least four drugs (controlled TRH: 1383; uncontrolled TRH: 5591)...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29594256/from-consternation-to-revelation-discovery-of-a-role-for-igsf1-in-pituitary-control-of-thyroid-function
#14
REVIEW
Daniel J Bernard, Emilie Brûlé, Courtney L Smith, Sjoerd D Joustra, Jan M Wit
Immunoglobulin superfamily, member 1 (IGSF1) is a transmembrane glycoprotein highly expressed in the mammalian pituitary gland. Shortly after its discovery in 1998, the protein was proposed to function as a coreceptor for inhibins (and was even temporarily renamed inhibin binding protein). However, subsequent investigations, both in vitro and in vivo , failed to support a role for IGSF1 in inhibin action. Research on IGSF1 nearly ground to a halt until 2011, when next-generation sequencing identified mutations in the X-linked IGSF1 gene in boys and men with congenital central hypothyroidism...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29587179/molecular-characterization-antibiotic-resistance-pattern-and-biofilm-formation-of-vibrio-parahaemolyticus-and-v-cholerae-isolated-from-crustaceans-and-humans
#15
Heba A Ahmed, Rasha M El Bayomi, Mohamed A Hussein, Mariam H E Khedr, Etab M Abo Remela, Ahmed M M El-Ashram
Human infection with pathogenic vibrios is associated with contaminated seafood consumption. In the present study, we examined 225 crustaceans collected from retail markets in Egypt. Stool samples from gastroenteritis patients were also examined. Bacteriological and molecular examinations revealed 34 (15.1%) V. parahaemolyticus and 2 (0.9%) V. cholerae from crustaceans, while V. parahaemolyticus isolates were identified in 3 (3%) of the human samples. The virulence-associated genes tdh and/or trh were detected in 5...
March 21, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29574218/central-irisin-administration-suppresses-thyroid-hormone-production-but-increases-energy-consumption-in-rats
#16
Suat Tekin, Yavuz Erden, Fatma Ozyalin, Ebru Etem Onalan, Yilmaz Cigremis, Cemil Colak, Ibrahim Tekedereli, Suleyman Sandal
Irisin, which is secreted from the skeletal muscle in response to physical exercise and defined as a thermogenic peptide, may play an important role in energy metabolism. Thyroid hormones, which are one of the other influential factors on the metabolic status, increase heat production and are the main regulators of energy metabolism. This study was conducted to determine the possible effects of irisin administration on thyroid hormones. Forty adult male Wistar albino rats were used in the study. The rats were equally divided into 4 groups (n = 10)...
March 21, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29556217/molecular-and-conventional-analysis-of-acute-diarrheal-isolates-identifies-epidemiological-trends-antibiotic-resistance-and-virulence-profiles-of-common-enteropathogens-in-shanghai
#17
Feng Yang, Yonggen Jiang, Lihua Yang, Juanxiu Qin, Mingquan Guo, Yuxia Lu, Hongyou Chen, Yuan Zhuang, Jinghao Zhang, Hong Zhang, Zhaoyun Dai, Min Li, Changqing Yang, Min Chen, Yanmei Zhang, Hu Zhao
Objective: To investigate prevalence of acute diarrhea in Shanghai and analyze virulence associated-genes and antibiotic resistance of major enteropathogens using combination of conventional and molecular epidemiology methods. Method: The 412 stool specimens were obtained by systematic sampling from diarrhea patients throughout entire year 2016. Bacterial and viral pathogens were identified and bacterial isolates were cultured and screened for antibiotic resistance profiles. Two most prevalent bacteria, Vibrio parahaemolyticus and Salmonella were further typed by multi-locus sequence typing (MLST) and analyzed for presence of virulence-associated genes...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29543524/varying-success-of-relaying-to-reduce-vibrio-parahaemolyticus-levels-in-oysters-crassostrea-virginica
#18
Michael A Taylor, Jong W Yu, Thomas L Howell, Stephen H Jones
Vibrio parahaemolyticus is the leading cause of seafood-borne human infections in the United States, and many of these illnesses are associated with consumption of raw molluscan shellfish. V. parahaemolyticus levels in shellfish vary temporally and spatially with environmental conditions in and around production areas. The objective of this study was to study the potential for reducing levels of V. parahaemolyticus in live oysters by relaying them during higher-risk warm weather to a site with elevated salinity and consistently low V...
April 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29517352/prevalence-of-vibrio-spp-in-retail-seafood-in-berlin-germany
#19
Thi Thu Tra Vu, Thomas Alter, Stephan Huehn
This study was conducted to determine the prevalence of Vibrio spp. in retail seafood in Berlin, Germany. A total of 160 raw seafood samples from supermarkets and seafood shops, consisting of shrimp ( n = 80) and bivalves ( n = 80), were investigated for the presence of Vibrio spp. using the International Organization for Standardization ISO/TS 21872 method and a multiplex PCR. The overall prevalence of Vibrio spp. in retail seafood was 55% (95% CI: 47.2 to 62.8%). The prevalence of Vibrio spp. in shrimp was slightly higher than in bivalves (57...
April 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29498920/update-on-the-clinicopathology-of-pituitary-adenomas
#20
Chung Thong Lim, Márta Korbonits
Pituitary adenomas are the third most common central nervous system tumours and arise from the anterior pituitary within the pituitary fossa. The signs and symptoms of patients with pituitary adenomas vary from 'mass effects' caused by a large adenoma to features secondary to excess pituitary hormones produced by the functioning pituitary adenoma. Detailed histopathological assessment, based on novel classifications and the latest WHO guidelines, helps to categorise pituitary adenomas into different subtypes and identify features that, in some cases, help to predict their behaviour...
March 2, 2018: Endocrine Practice
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