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Raman spectra

Marc-Olivier Baradez, Daniela Biziato, Enas Hassan, Damian Marshall
Cell therapies offer unquestionable promises for the treatment, and in some cases even the cure, of complex diseases. As we start to see more of these therapies gaining market authorization, attention is turning to the bioprocesses used for their manufacture, in particular the challenge of gaining higher levels of process control to help regulate cell behavior, manage process variability, and deliver product of a consistent quality. Many processes already incorporate the measurement of key markers such as nutrient consumption, metabolite production, and cell concentration, but these are often performed off-line and only at set time points in the process...
2018: Frontiers in Medicine
Xiaozhou Li, Tianyue Yang, Caesar Siqi Li, Youtao Song, Hong Lou, Dagang Guan, Lili Jin
In this paper, we discuss the use of a procedure based on polymerase chain reaction (PCR) and surface enhanced Raman spectroscopy (SERS) (PCR-SERS) to detect DNA mutations. Methods: This method was implemented by first amplifying DNA-containing target mutations, then by annealing probes, and finally by applying SERS detection. The obtained SERS spectra were from a mixture of fluorescence tags labeled to complementary sequences on the mutant DNA. Then, the SERS spectra of multiple tags were decomposed to component tag spectra by multiple linear regression (MLR)...
2018: Theranostics
Rahat Ullah, Saranjam Khan, Samina Javaid, Hina Ali, Muhammad Bilal, Muhammad Saleem
This study presents differentiation in milk samples of mother's feeding male and female infants using Raman spectroscopy combined with a support vector machine (SVM). Major differences have been observed in the Raman spectra of both types of milk based on their chemical compositions. Overall, it has been found that milk samples of mother's having a female infant are richer in fatty acids, phospholipids, and tryptophan. In contrast, milk samples of mother's having a male infant contain more carotenoids and saccharides...
February 1, 2018: Biomedical Optics Express
Y Yoshioka, E Yamachika, M Nakanishi, T Ninomiya, K Nakatsuji, M Matsubara, N Moritani, Y Kobayashi, T Fujii, S Iida
Bone quality is defined by structural and material characteristics. Most studies on the mandible have focused on the analysis of structural characteristics, with insufficient investigation of material characteristics. This study tested whether zoledronate affects the material characteristics of newly formed mandibular bone. Thirty-six female Wistar rats were assigned to three groups: sham-ovariectomized rats (SHAM, n=12), ovariectomized rats (OVX, n=12), and ovariectomized rats treated with zoledronate (ZOL, n=12)...
March 14, 2018: International Journal of Oral and Maxillofacial Surgery
A Garbout, M Férid
Considering the features in changing the structure and properties of rare earth titanates pyrochlores, the substituted Dy2 Ti2 O7 may be very attractive for various applications. Effect of Sm and Y substitution on the structural properties of Dy2 Ti2 O7 ceramic was established. These ceramics were prepared by solid-state reaction and characterized by X-ray diffraction and Raman spectroscopy. Both analysis show that YDyTi2 O7 with the pyrochlore structure is obtained after heating at 1400°C, but SmDyTi2 O7 has already formed after sintering at 1200°C...
March 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Martin Kornecki, Jochen Strube
Productivity improvements of mammalian cell culture in the production of recombinant proteins have been made by optimizing cell lines, media, and process operation. This led to enhanced titers and process robustness without increasing the cost of the upstream processing (USP); however, a downstream bottleneck remains. In terms of process control improvement, the process analytical technology (PAT) initiative, initiated by the American Food and Drug Administration (FDA), aims to measure, analyze, monitor, and ultimately control all important attributes of a bioprocess...
March 16, 2018: Bioengineering
Takashi Ikeda
The nuclear quantum effects (NQEs) on the structural, elastic, electronic, and vibrational properties of high pressure ices (HPIs) VIII, VII, and X at 270 K were investigated via first principles centroid molecular dynamics (CMD). Our simulations clearly show that even at relatively high temperature of 270 K, the NQEs play a definite role in the pressure-induced proton order (ice VIII)-disorder (ice VII) transition occurring at ∼30 GPa in our H2 O ice and the subsequent transition to the symmetric phase ice X suggested to occur at ∼80 GPa...
March 14, 2018: Journal of Chemical Physics
Hao Huang, Xiaohui Ren, Zhongjun Li, Huide Wang, Zongyu Huang, Hui Qiao, Pinghua Tang, Jinlai Zhao, Weiyuan Liang, Yanqi Ge, Jie Liu, Jianqing Li, Xiang Qi, Han Zhang
Two dimensional (2D) Bi nano-sheets had been employed to fabricate electrodes for broadband photo-detection. A series of characterization techniques including SEM and HRTEM verify that Bi nanosheets with intact lamellar structure have been obtained after facile liquid phase exfoliation. In the meanwhile, UV-Vis and Raman spectra are also carried out and confirm the inherent optical and physical properties of Bi nanosheets. Inherited from the topological characteristics of Bi bulk counterpart, the resultant Bi nanosheet-based photo-detector exhibits preferable photo-response activity as well as environmental robustness...
March 15, 2018: Nanotechnology
Melissa P Woodard, Scott T Akin, Collin J Dibble, Michael A Duncan
Ultra-small chromium oxide nanoclusters produced by laser vaporization in a fast flowtube reactor are ligand-coated by gas phase reactions with acetonitrile vapor and then captured in a cold trap and transferred to solution. The resulting clusters are characterized with mass spectrometry, UV-visible absorption and emission, infrared spectroscopy, and surface-enhanced Raman spectroscopy (SERS). According to mass spectrometry, clusters of the form CrxOy(MeCN)z are produced in the size range of x  10 and y < 25...
March 15, 2018: Journal of Physical Chemistry. A
Kelly Aubertin, Vincent Quoc Trinh, Michael Jermyn, Paul Baksic, Andrée-Anne Grosset, Joannie Desroches, Karl St-Arnaud, Mirela Birlea, Maria Claudia Vladoiu, Mathieu Latour, Roula Albadine, Fred Saad, Frédéric Leblond, Dominique Trudel
OBJECTIVE: To test if Raman spectroscopy is an appropriate tool for the diagnosis and possibly the grading of prostate cancer. PATIENTS & METHODS: Between 20 and 50 Raman spectra were acquired on 32 fresh and non-processed post-prostatectomy specimens using a macroscopic hand-held Raman spectroscopy probe. Each measured area was characterized and categorized following histopathological criterions like tissue type (extra-prostatic or prostatic), tissue malignancy (benign or malignant), cancer grade (Grade Groups (GG) 1-5), and tissue glandular level...
March 15, 2018: BJU International
Wen-Yi Zhou, Shan-Shan Li, Jieyao Song, Min Jiang, Tian-Jia Jiang, Jinyun Liu, Jinhuai Liu, Xing-Jiu Huang
Mutual interference is a severe issue that occurs during the electrochemical detection of heavy metal ions. This limitation presents a notable drawback for its high sensitivity to specific targets. Here, we present a high electrochemical sensitivity of ~237.1 μA cm-2 μM-1 toward copper(II) [Cu(II)] based on oxygen-deficient titanium dioxide (TiO2-x) nanosheets. We fully demonstrated an atomic-level relationship between electrochemical behaviors and the key factors, including the high-energy (001) facet percentage, oxygen vacancy concentration, surface -OH content, and charge carrier density, is fully demonstrated...
March 15, 2018: Analytical Chemistry
Wataru Sato, Takeshi Uchida, Tomohide Saio, Koichiro Ishimori
Cytochrome c (Cyt c) was rapidly oxidized by molecular oxygen in the presence, but not absence of PEG. The redox potential of heme c was determined by the potentiometric titration to be +236 ± 3 mV in the absence of PEG, which was negatively shifted to +200 ± 4 mV in the presence of PEG. The underlying the rapid oxidation was explored by examining the structural changes in Cyt c in the presence of PEG using UV-visible absorption, circular dichroism, resonance Raman, and fluorescence spectroscopies...
March 11, 2018: Biochimica et Biophysica Acta
Marco Sbroscia, Armida Sodo, Fabio Bruni, Tommaso Corridoni, Maria Antonietta Ricci
The concept of ions being either water "structure makers" or "breakers" seems to be not consistent with the existence of a critical number of water molecules per ion dictating the properties of an aqueous solution, independently of the ion identity. To investigate this issue, Raman spectra of hydroxides aqueous solutions in the region of the OH stretching mode have been obtained at ambient conditions and at concentrations ranging from extreme dilution to the solubility limit. Spectra have been analyzed with a relatively model free approach, in terms of a superposition of contributions due to the vibrations of the OH ions, with two contributions due to the solvent...
March 13, 2018: Journal of Physical Chemistry. B
Ina Strauss, Alexander Mundstock, Dominik Hinrichs, Rasmus Himstedt, Alexander Knebel, Carsten Reinhardt, Dirk Dorfs, Jürgen Caro
Co-MOF-74 rod like crystals with a length of several hundred micrometers have been synthesized via a solvothermal procedure and their interaction with different gases has been evaluated in view of selective gas sensing. We show strongly anisotropic absorption behaviour of the Co-MOF-74 crystals when illuminated with polarized light. This study then addresses the interactions of guests (CO2, propane, propene, Ar, MeOH, H2O) with Co-MOF-74, studied by various spectroscopic techniques. Via Vis/NIR measurements, peak shifts of Co-MOF-74 depending on the interaction with the guest molecules were observed and distinguished...
March 13, 2018: Angewandte Chemie
Aidan D Meade, Adrian Maguire, Jane Bryant, Daniel Cullen, Dinesh Medipally, Lisa White, Brendan McClean, Laura Shields, John Armstrong, Mary Dunne, Emma Noone, Shirley Bradshaw, Marie Finn, Aoife M Shannon, Orla Howe, Fiona M Lyng
PURPOSE: Liquid biopsies are a potentially rich store of biochemical information that can be linked to an individual's response to therapeutic treatments, including radiotherapy, and which may ultimately play a role in the individualization of treatment regimens. Peripheral blood mononuclear cells (PBMCs) can be used for the biochemical profiling of the individual, but also, being living cells, can provide insights into the individuals response to ionizing radiation exposure. MATERIAL AND METHODS: The present study attempts to link the biochemical profile of lymphocytes within PBMCs obtained through Raman spectroscopy, to in-vitro measures of low-dose (< 0...
March 12, 2018: International Journal of Radiation Biology
Egor A Kolesov, Mikhail S Tivanov, Olga V Korolik, Olesya O Kapitanova, Xiao Fu, Hak Dong Cho, Tae Won Kang, Gennady N Panin
Atmospheric doping of supported graphene was investigated by Raman scattering under different pressures. Various Raman spectra parameters were found to depend on the pressure and the substrate material. The results are interpreted in terms of atmospheric adsorption leading to a change in graphene charge carrier density and the effect of the substrate on the electronic and phonon properties of graphene. It was found that adsorption of molecules from the atmosphere onto graphene doped with nitrogen (electron doping) compensates for the electron charge...
2018: Beilstein Journal of Nanotechnology
J Silveira, S Coutinho, D Marques, J Castro, A Mata, M L Carvalho, S Pessanha
In this work we present the analysis of dental enamel treated with an over-the-counter whitening product, bought in e-commerce at a very low cost, used without medical supervision in an abusive manner, in order to evaluate its demineralization action. Moreover, we studied the influence of renewal or non-renewal of saliva solution in which the specimens were stored throughout the study. The Degree of Demineralization was determined through the evaluation of the PO4 3- symmetric stretching band (~959cm-1 ) in Raman spectra of the specimens in different days during the course of the study...
March 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Juan Yang, Min Xu, Jingyu Wang, Shangbin Jin, Bien Tan
In this paper, we proposed a new strategy to prepare multiple heteroatom doped (N, P-doped) porous carbon materials with high surface area of ~1,535 m2 g-1 simply by pyrolysis of imine-linked porous organic polymers (POPs) synthesized via Schiff base condensation. The strategy is simple without any post-processing and various heteroatoms could be involved. Scanning electron microscopy, Raman spectra, Nitrogen gas adsorption-desorption, X-ray photoelectron spectroscopy have been used to characterize the morphology, the structure and the composition of the materials...
March 9, 2018: Scientific Reports
Raju Botta, Pongpan Chindaudom, Pitak Eiamchai, Mati Horprathum, Saksorn Limwichean, Chanunthorn Chananonnawathorn, Viyapol Patthanasettakul, Benjawan Kaewseekhao, Kiatichai Faksri, Noppadon Nuntawong
Nanostructures have been multiplying the advantages of Raman spectroscopy and further amplify the advantages of Raman spectroscopy is a continuous effort focused on the appropriate design of nanostructures. Herein, we designed different shapes of plasmonic nanostructures such as Vertical, Zig Zag, Slant nanorods and Spherical nanoparticles employing the DC magnetron sputtering system as SERS-active substrates for ultrasensitive detection of target molecules. The fabricated plasmonic nanostructures sensitivity and uniformity were exploited by reference dye analyte...
January 2018: Tuberculosis
Guillaume Falgayrac, Damian Siepka, Elżbieta A Stefaniak, Guillaume Penel, Sophie Sobanska
The influence of six common substrates on the Raman imaging of micron-sized inorganic aerosol particles was examined. Laboratory-generated single-component particles of calcite (CaCO3 ) and mixed particles of calcite (CaCO3 ), nitratine (NaNO3 ), hematite (Fe2 O3 ) and anglesite (PbSO4 ) were deposited by cascade impaction on Ag, In, Si, SiO2 , microscope slide and TEM-grid substrates. The spectral contribution of substrates to Raman images of the deposited particles was evaluated by Multivariate Curve Resolution...
July 19, 2018: Analytica Chimica Acta
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