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Wen-Li Wu, Xuan Zhao, Long-Long Xi, Miao-Fei Huang, Wen-Hui Zeng, Jun-Ying Miao, Bao-Xiang Zhao
A mitochondria-targeted fluorescence probe (CPBT) for ratiometric detection of endogenous hypochlorite in the living cells was developed. CPBT could detect hypochlorite with high selectivity and sensitivity in a ratiometric manner based on FRET mechanism. In absence of hypochlorite, when CPBT was excited with absorption maximum wavelength of the donor moiety, it showed the emission of acceptor moiety because of FRET process. However, in the presence of hypochlorite, the reaction of CC double bond with hypochlorite interrupted the conjugation system resulting in the inhibition of FRET process and the emission of the donor moiety...
January 15, 2017: Analytica Chimica Acta
Bradley W M Cook, Todd A Cutts, Aidan M Nikiforuk, Anders Leung, Darwyn Kobasa, Steven S Theriault
The recent Ebola virus outbreak in West Africa has forced experts to re-evaluate their understanding of how to best disinfect areas contaminated with infectious bodily fluids. Recent research has found that Ebola virus remains viable in blood for 7-10 days making appropriate disinfection crucial to infection control. We sought to determine if the three most important outbreak variants of Zaire ebolavirus (Mayinga, Kikwit and Makona) exhibit separate phenotypes when challenged with a range of sodium hypochlorite (NaOCl) concentrations or 70% ethanol (EtOH) at average West African temperature...
December 2, 2016: Scientific Reports
Yang Zhang, Jie Wang, Fei Gao, Yongsheng Chen, Hongwei Zhang
Chemical ageing of ultrafiltration membranes related to drinking water operation is not a new problem, but literature documenting sieving properties and fouling behaviors of aged membranes are scarce. This paper shows how the surface chemistry evolution of polysulfone (PSF) and polyvinylidene fluoride (PVDF) membranes can lead to the formation of distinct membrane properties when exposed to sodium hypochlorite solutions. The surface physicochemical evolutions of aged membranes are characterized based on chemical composition (ATR-FTIR and XPS), water contact angle analysis, and surface zeta potential test...
November 7, 2016: Water Research
Can Wang, Hongyu Ji, Mengshu Li, Likun Cai, Zhipeng Wang, Qianqian Li, Zhen Li
As a reactive oxygen species (ROS), hypochlorite (OCl(-)) plays a crucial role in oxidative stress and signal transduction, controlling a wide range of physiological functions. In addition, the wide use of OCl(-) in the treatment of food and water might possibly threaten human health if the residual quantity was out of limits. Currently, sensitive methods employed to selectively monitor OCl(-) in aqueous samples in situ are still scarce and badly needed. Boron esters or acids are considered to be suitable functional groups for the detection of hydrogen peroxide due to their reliable reactivity...
November 28, 2016: Faraday Discussions
M Becker, J Ciupka, T Pierchalla, K R Fischer, A Friedmann
OBJECTIVES: A solution based on hypochlorite and amino acids was introduced to improve cleaning efficacy on the root surfaces. The purpose of this in vitro pilot study was to evaluate the time reduction and number of strokes required to clean untreated root surfaces in vitro. METHODS: Sixty extracted human teeth displaying areas with subgingival calculus were assigned equally to one of three treatment groups (n = 20) according to the size of occupied areas, estimated by the number of pixels...
November 28, 2016: International Journal of Dental Hygiene
S Lata, Soumya Kanta Mohanty, Prasanti Kumari Pradhan, Gaurav Patri, Sachidananda Prasad Sinha, Pratik Agrawal
INTRODUCTION: Sodium hypochlorite, is the irrigant of choice for many clinicians, but its strong toxic and damaging effects on vital periapical tissues is always a matter of concern. So, the search for a root canal irrigant with a broad antimicrobial spectrum yet with a limited toxicity on vital tissues is always desirable. AIM: The study evaluated antimicrobial efficacy of Electro-Chemically Activated (ECA) water as a root canal irrigant against E. faecalis. MATERIALS AND METHODS: Forty eight single rooted human teeth were decoronated to a length of 15mm...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
Bathula Vimala Chaitanya, Kusum Valli Somisetty, Abhinav Diwan, Shiraz Pasha, Nandaprasad Shetty, Yashwanth Reddy, Shankar Nadigar
INTRODUCTION: Sodium hypochlorite (NaOCl), the most commonly used irrigant, has many potential properties like its unique ability to dissolve pulp tissue, excellent antimicrobial activity, but has a cytotoxic effect when injected into periapical tissues. It is also known to produce allergic reactions, foul smell and taste, and potential for corrosion. Facultative organisms such as Enterococcus faecalis and aerobes like Staphylococcus aureus are considered to be the most resistant species and one of the possible causes of root canal treatment failure...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
Fatemah Faras, Fawaz Abo-Alhassan, Abdullah Sadeq, Hisham Burezq
Sodium Hypochlorite (NaOCl) is a common irrigation solution used in root canal treatment. It has strong antibacterial and tissue dissolving properties. Nevertheless, it has some serious complications, some of which are life-threatening. A young male presented with severe chemical burn of the right infraorbital area and partial necrosis of the hard palate resulting from extrusion of NaOCl during root canal treatment of the upper right 2(nd) molar tooth. The patient had a facial scar, and mucosal damage healed nearly completely...
September 2016: Journal of International Society of Preventive & Community Dentistry
Audrey Charlebois, Mario Jacques, Martine Boulianne, Marie Archambault
Clostridium perfringens is an opportunistic pathogen that can cause food poisoning in humans and various enterotoxemia in animal species. Recently, it was shown to form mono-species biofilms, a structured community of bacterial cells enclosed in a self-produced extracellular matrix. Biofilms have been associated with tolerance to antibiotics, disinfectants, and physical and environmental stresses. Very little is known about the tolerance of C. perfringens biofilm toward disinfectants. In the present study, susceptibilities of C...
April 2017: Food Microbiology
Radka Pecková, Peter D Stuart, Bohumil Sak, Dana Květoňová, Martin Kváč, Ivona Foitová
Excystation of sporozoites of Cryptosporidium parvum from oocysts is essential for successful in vitro assays. It has also been traditionally used as a measure for oocyst viability and infectivity. Laboratories use various excystation protocols so there is a need to clarify which method is the best. In this study, six different protocols for in vitro excystation of C. parvum oocysts were compared to find the most efficient excystation method (expressed as percentage excystation). Tested protocols differed in chemical pre-incubation steps, excystation media or time of incubation...
October 30, 2016: Veterinary Parasitology
Yutaka Isakozawa, Heihachi Migita, Shingo Takesawa
BACKGROUND: Central dialysate fluid delivery systems (CDDS) are used by dialysis centers in Japan, and although these systems are effective at delivering dialysate, they have a complex piping network with numerous sites where contamination can develop. In Japan, cleaning disinfectants have been clinically evaluated based on endotoxin levels and bacterial counts, but there have been no published studies evaluating the biofilm removal efficacy of these agents at the electron microscope level...
September 2016: Nephro-urology Monthly
Alexa C Rosypal, Alice Houk-Miles, Anne M Zajac, David S Lindsay
Toxocara canis is a common intestinal nematode of young dogs. Puppies contaminate the environment with large numbers of eggs that can embryonate and become infective in less than a month. Embryonated eggs are infectious for humans and other paratenic hosts. Most T. canis infections in humans are asymptomatic, however, migration of T. canis larvae in the eye and in the central nervous system can result in vision loss, blindness, and even death. The eggs of T. canis are highly resistant to harsh environmental conditions and routinely used chemical disinfectants...
November 22, 2016: Journal of Parasitology
Brent Moore, Konstantinos Verdelis, Anil Kishen, Thuan Dao, Shimon Friedman
INTRODUCTION: Recently, we reported that in mandibular molars contracted endodontic cavities (CECs) improved fracture strength compared with traditional endodontic cavities (TECs) but compromised instrumentation efficacy in distal canals. This study assessed the impacts of CECs on instrumentation efficacy and axial strain responses in maxillary molars. METHODS: Eighteen extracted intact maxillary molars were imaged with micro-computed tomographic imaging (12-μm voxel), assigned to CEC or TEC groups (n = 9/group), and accessed accordingly...
December 2016: Journal of Endodontics
Jiawei Li, Tao Liu, Fangjun Huo, Jianbin Chao, Yongbin Zhang, Caixia Yin
Two simple, efficient turn-on fluorescent probes for hypochlorite have been rationally designed and developed by utilizing the oxidation of hypochlorite. Notably, probe 1 and 2 displayed rapid and remarkable turn-on responses to ClO(-) in PBS buffer solution (pH7.4). Further, the optical properties of two probes and their ClO(-)-addition products were confirmed by density functional theory calculations. And detection limits of two probes for ClO(-) based on the definition by IUPAC were calculated for 2.882nM and 0...
November 14, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Krzysztof Żamojć, Magdalena Zdrowowicz, Paweł Błażej Rudnicki-Velasquez, Karol Krzymiński, Bartłomiej Zaborowski, Paweł Niedziałkowski, Dagmara Jacewicz, Lech Chmurzyński
1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals. Under the action of these individuals DPBF has been rapidly transformed to 1,2-dibenzoylbenzene...
November 20, 2016: Free Radical Research
Adrianne N Edwards, Samiha T Karim, Ricardo A Pascual, Lina M Jowhar, Sarah E Anderson, Shonna M McBride
Clostridium difficile is a Gram-positive, sporogenic and anaerobic bacterium that causes a potentially fatal colitis. C. difficile enters the body as dormant spores that germinate in the colon to form vegetative cells that secrete toxins and cause the symptoms of infection. During transit through the intestine, some vegetative cells transform into spores, which are more resistant to killing by environmental insults than the vegetative cells. Understanding the inherent resistance properties of the vegetative and spore forms of C...
2016: Frontiers in Microbiology
Aji Markose, Ramesh Krishnan, Maya Ramesh, Shishir Singh
INTRODUCTION: In multiple-appointment root canal treatment, a temporary filling material is used to seal the access cavity between visits. The primary function of this material is to prevent the contamination of the root canal system by fluids, organic debris, and bacteria from the oral cavity. MATERIAL AND METHODS: A total of fifty extracted noncarious unrestored human maxillaryanterior teeth with intact crowns and roots were selected The canals were instrumented using stepback technique and sodium hypochlorite (3%) and hydrogen peroxide (3%) were used as irrigants for each specimen alternatively...
October 2016: Journal of Pharmacy & Bioallied Sciences
Bulem Yuzugullu, Ozlem Acar, Cem Cetinsahin, Cigdem Celik
PURPOSE: The aim of this study was to compare the effects of different denture cleansers on the surface roughness and microhardness of various types of posterior denture teeth. MATERIALS AND METHODS: 168 artificial tooth specimens were divided into the following four subgroups (n=42): SR Orthotyp PE (polymethylmethacrylate); SR Orthosit PE (Isosit); SR Postaris DCL (double cross-linked); and SR Phonares II (nanohybrid composite). The specimens were further divided according to the type of the denture cleanser (Corega Tabs (sodium perborate), sodium hypochlorite (NaOCl), and distilled water (control) (n=14)) and immersed in the cleanser to simulate a 180-day immersion period, after which the surface roughness and microhardness were tested...
October 2016: Journal of Advanced Prosthodontics
Md Niamul Haque, Sunghyun Kwon
Biofouling is a stubborn problem in cooling systems where using raw water from lakes, rivers, and sea. The effect of ultrasound and its sequential application with sodium hypochlorite (chlorination) upon marine bivalve Mytilus edulis (blue mussel), a massive fouling organism, has been studied and discussed here. The results obtained from the work carried out have shown that 42 kHz ultrasound is better than 28 kHz in accordance with veliger larvae mortality. The 42 kHz ultrasound has enhanced the mortality rate of veliger larvae than only free-residual chlorination up to 99%...
November 5, 2016: Environmental Geochemistry and Health
Charis Beltes, Hercules Sakkas, Nikolaos Economides, Chrissanthy Papadopoulou
BACKGROUND: The use of Antimicrobial Photodynamic Therapy (aPDT) has been suggested as an adjuvant method to eliminate facultative bacteria during root canal disinfection. The purpose of this preliminary in vitro study was to determine whether the light-activated antimicrobial agent, Indocyanine green (ICG), could be used as photosensitizer and kill Enterococcus faecalis strain under planktonic conditions when irradiated with near-infared (NIR) diode laser emitting in 810nm wavelength...
November 2, 2016: Photodiagnosis and Photodynamic Therapy
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