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sinonasal papillomas

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https://www.readbyqxmd.com/read/28207194/clinical-outcomes-of-sinonasal-squamous-cell-carcinomas-based-on-tumor-etiology
#1
Carol H Yan, Jason G Newman, David W Kennedy, James N Palmer, Nithin D Adappa
BACKGROUND: Squamous cell carcinoma (SCC) of the sinonasal cavity is a rare entity that arises as either de-novo tumors or from inverted papillomas (IPs). In this study we evaluate and compare oncologic outcomes of sinonasal SCCs based on their etiology and treatment strategy. METHODS: This investigation was a single-center, retrospective review comparing de-novo SCCs (n = 28) and those associated with IPs (n = 38) resected during the period from 2000 to 2015. Demographic and tumor data, surgical approach, recurrence, and clinical outcomes were analyzed...
February 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28060369/virus-associated-neoplasms-of-the-nasopharynx-and-sinonasal-tract-diagnostic-problems
#2
John Kc Chan
A significant fraction of nasopharyngeal and sinonasal tumors are associated with Epstein-Barr virus (EBV) or human papillomavirus (HPV). Nasopharyngeal carcinoma (NPC) and extranodal NK/T-cell lymphoma harbor EBV in practically all cases, although a small proportion of cases of the former harbor HPV. Sinonasal inverted papillomas harbor HPV in about 25% of cases. Sinonasal squamous cell carcinomas harbor transcriptionally active HPV in about 20% of cases, and limited data suggest that this subset has a better prognosis than the HPV-negative subset...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28050382/intestinal-type-adenocarcinoma-from-inverted-papilloma-a-rare-recurrence
#3
Garima Singh, Meeta Singh, Mansi Chandana, Sompal Singh, Namrata Nargotra
Inverted Papilloma (IP) is an uncommon and locally aggressive benign tumour of sinonasal region, which tends to recur after surgical resection. Most tumours are confined to the lateral nasal wall and sinuses, with maxillary sinus being most commonly affected and a male preponderance. It has a known association with in situ and invasive carcinomas with a <10% rate of malignant transformation. Most common association has been seen with squamous cell carcinoma and extremely rare association with adenocarcinoma and small cell carcinoma...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27993194/sinonasal-papillomas-in-a-private-referral-otorhinolaryngology-centre-review-of-22-years-experience
#4
Aderito de Sousa Fontes, Minaret Sandrea Jiménez, Nelson Urdaneta Lafée, Perfecto A Abreu Durán, Liwven E Quintana Páez, Andreina Carmina de Sousa de Abreu
OBJECTIVES: To evaluate the clinical presentation, treatment outcome and follow-up of all patients managed with sinonasal papillomas (SP), at a tertiary private otorhinolaryngology centre in Caracas (Venezuela). MATERIAL AND METHODS: We reviewed 94 patients with SP that were treated at our otolaryngology center, from July 1st 1993 to June 31st 2015. The demographic data, clinical features, radiological findings, anatomical origin, disease extension into the adjacent structures, surgical approaches performed, histopathology outcomes, recurrent risk, malignant transformation rate and coadjuvant therapies were assessed...
December 16, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27930867/squamous-cell-carcinoma-associated-with-inverted-papilloma-of-the-maxillary-sinus-our-experience-with-21-patients
#5
Myeong Sang Yu, Won Sub Lim, Bong-Jae Lee, Yoo-Sam Chung
Sinonasal inverted papillomas (IP) are benign tumors, which represent 0.5-7.0% of all diagnosed sinonasal tumors,(1) and exhibit malignant characteristics, including high rates of recurrence and local aggressiveness and association with malignancy.(1) The incidence of IP associated with SCC differs widely according to various reports (2-53%).(2,3) IP-associated SCC is not considered to be simply a mixture of the two other primary tumors, but rather a malignant transformation of the IP.(3) This article is protected by copyright...
December 8, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27922925/update-on-nonmalignant-lesions-of-the-inferior-turbinate
#6
Jared M Goldfarb, David Goldfarb, Marc R Rosen
PURPOSE OF REVIEW: The inferior turbinates are routinely examined by otolaryngologists on anterior rhinoscopy and nasal endoscopy. Most lesions of the inferior turbinate are benign but can often be confused with malignancy. This review highlights the broad differential of nonmalignant lesions of the inferior turbinates and their management. RECENT FINDINGS: A variety of infectious, inflammatory, neoplastic, and vascular lesions may affect the inferior turbinates...
February 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27906054/is-radical-surgery-of-an-inverted-papilloma-of-the-maxillary-sinus-obsolete-a-case-report
#7
Vedat Yildirim, Niels Christian Pausch, Dirk Halama, Heinz-Theo Lübbers, Ayhan Yildirim
BACKGROUND: Sinonasal inverted papilloma is a locally aggressive tumor arising from the Schneiderian membrane which lines the nasal cavity and paranasal sinuses. Aggressive surgical approaches, such as lateral rhinotomy, were used until recently for complete removal of the inverted papilloma. Currently, endoscopic resection is the gold standard in the treatment of inverted papilloma. However, there are situations that justify an open approach. For example there are studies that report a higher postoperative recurrence rate after endonasal endoscopic resection, particularly in the treatment of recurrent diseases...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27773333/ossifying-inverted-papilloma-and-ossifying-polyp%C3%A2-of-the-sinonasal-tract-comparison-of%C3%A2-ct%C3%A2-and%C3%A2-mri-features
#8
B T Yang, Y Z Wang, F R Sun, J Y Dong
AIM: To investigate the key imaging points in distinguishing ossifying inverted papilloma (IP) from polyps. MATERIALS AND METHODS: The native computed tomography (CT), conventional and enhanced MRI manifestations of 20 ossifying IPs and eight polyps, which were confirmed histopathologically, were retrospectively evaluated by two doctors majoring in head and neck imaging. RESULTS: A significant difference was detected between the two entities for the involved sites (p<0...
January 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27717197/postoperative-value-of-serum-squamous-cell-carcinoma-antigen-as-a-predictor-of-recurrence-in-sinonasal-inverted-papilloma
#9
F V W J van Zijl, D A Monserez, T I M Korevaar, O Bugter, M H Wieringa, R J Baatenburg de Jong, J A U Hardillo
:  OBJECTIVES: Sinonasal inverted papilloma (IP) has several unfavorable characteristics and therefore requires careful monitoring. The goal of this study was to identify whether serum squamous cell carcinoma antigen (SCCa) could predict IP recurrence. DESIGN: A retrospective cohort study. SETTING: Department of otolaryngology/head and neck surgery, Erasmus Medical Centre, Rotterdam, the Netherlands. PARTICIPANTS: 130 patients with IP treated at our centre with SCCa measurements available were included...
September 26, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27559965/sinonasal-oncocytic-schneiderian-papilloma-accompanied-by-intravascular-lymphoma-a-case-report-on-fdg-pet-ct-imaging
#10
Masamichi Koyama, Takashi Terauchi, Mitsuru Koizumi, Hiroko Tanaka, Kengo Takeuchi
INTRODUCTION: F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for the staging and assessment of treatment response in patients with lymphoma. Occasionally, benign lesions demonstrate avid FDG uptake and result in false positive findings. CASE: We report the case of an 82-year-old man presenting with cutaneous lesions, which were histopathologically diagnosed as intravascular lymphoma. FDG-PET/CT for staging demonstrated an FDG-avid mass extending from the right maxillary sinus to the nasal cavity, moderate uptake in the adrenal glands, mild uptake in the knee and the foot, and faint uptake in the skin and subcutaneous tissue of the legs...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27557563/prediction-of-the-originating-site-of-sinonasal-inverted-papilloma-by-preoperative-magnetic-resonance-imaging-and-computed-tomography
#11
Gaoli Fang, Hongfei Lou, Wenling Yu, Xiangdong Wang, Bentao Yang, Junfang Xian, Xiaohong Song, Erzhong Fan, Ying Li, Chengshuo Wang, Luo Zhang
BACKGROUND: Precise localization and excision of the originating site of a sinonasal inverted papilloma (SNIP) is essential for decreasing tumor recurrence. In this study we evaluated the use of preoperative computed tomography (CT) and magnetic resonance imaging (MRI) to pinpoint the attachment/originating sites of SNIPs in 143 patients. METHODS: Osteitis signs in CTs and convoluted cerebriform pattern (CCP)-based reverse tracings from MRIs of 143 SNIP patients were analyzed preoperatively to predict the originating site of SNIPs...
December 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27542897/bilateral-multifocal-inverted-papilloma-with-osseous-metaplasia-of-the-sinonasal-cavity
#12
Lokman Uzun, Seyma Ozkanli, M Tayyar Kalcioglu, Numan Kokten, Cigdem Kafkasli
No abstract text is available yet for this article.
July 30, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27531693/recurrence-of-sinonasal-inverted-papilloma-following-surgical-approach-a-meta-analysis
#13
Jong Seung Kim, Sam Hyun Kwon
OBJECTIVES/HYPOTHESIS: Inverted papilloma (IP) is a rare benign tumor, which is found in the sinonasal area. It is characterized by recurrence, local destruction, and malignant change. Of these, recurrence is a challenging problem to many otolaryngologists. In this study, we evaluated recurrence based on the type of surgical approach using a meta-analysis. STUDY DESIGN: MEDLINE, Embase, and Cochrane database. METHODS: Relevant studies were identified by searching the following databases: MEDLINE, Embase, and Cochrane through February 2016...
January 2017: Laryngoscope
https://www.readbyqxmd.com/read/27516190/importance-of-tumour-suppressor-gene-methylation-in-sinonasal-carcinomas
#14
M Chmelařová, I Sirák, M Mžik, K Sieglová, H Vošmiková, P Dundr, K Němejcová, J Michálek, M Vošmik, V Palička, J Laco
Epigenetic changes are considered to be a frequent event during tumour development. Hypermethylation of promoter CpG islands represents an alternative mechanism for inactivation of tumour suppressor genes, DNA repair genes, cell cycle regulators and transcription factors. The aim of this study was to investigate promoter methylation of specific genes in samples of sinonasal carcinoma by comparison with normal sinonasal tissue. To search for epigenetic events we used methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) to compare the methylation status of 64 tissue samples of sinonasal carcinomas with 19 control samples...
2016: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/27347158/sinonasal-spindle-cell-carcinoma-presenting-with-bilateral-visual-loss-a-case-report-and-review-of-the-literature
#15
Tsung-Wei Liu, Shih-Han Hung, Po-Yueh Chen
Spindle cell carcinoma (SpCC) is a rare variant of squamous cell carcinoma (SCC). SpCC of sinonasal origin is relatively rare and more aggressive than normal SCC. It most commonly involves the maxillary sinus, and rarely the sphenoid sinus. The present study reports a case of sphenoid sinus SpCC presenting with bilateral visual loss. Following endoscopic sinus decompression surgery, the patient was referred to the Oncology Department for a staging workup, and subsequently received concurrent chemoradiotherapy; however, the vision of the patient was not recovered, despite treatment...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27234382/activating-kras-mutations-are-characteristic-of-oncocytic-sinonasal-papilloma-and-associated-sinonasal-squamous-cell-carcinoma
#16
Aaron M Udager, Jonathan B McHugh, Bryan L Betz, Kathleen T Montone, Virginia A Livolsi, Raja R Seethala, Evgeny Yakirevich, O Hans Iwenofu, Bayardo Perez-Ordonez, Kathleen E DuRoss, Helmut C Weigelin, Megan S Lim, Kojo Sj Elenitoba-Johnson, Noah A Brown
Oncocytic sinonasal papillomas (OSPs) are benign tumours of the sinonasal tract, a subset of which are associated with synchronous or metachronous sinonasal squamous cell carcinoma (SNSCC). Activating EGFR mutations were recently identified in nearly 90% of inverted sinonasal papillomas (ISPs) - a related tumour with distinct morphology. EGFR mutations were, however, not found in OSP, suggesting that different molecular alterations drive the oncogenesis of these tumours. In this study, tissue from 51 cases of OSP and five cases of OSP-associated SNSCC was obtained retrospectively from six institutions...
August 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27152722/survival-outcomes-after-endoscopic-resection-for-sinonasal-squamous-cell-carcinoma-arising-on-inverted-papilloma
#17
Apostolos Karligkiotis, Davide Lepera, Luca Volpi, Mario Turri-Zanoni, Paolo Battaglia, Davide Lombardi, Remo Accorona, Maurizio Bignami, Piero Nicolai, Paolo Castelnuovo
BACKGROUND: Sinonasal inverted papillomas (IPs) can be associated synchronously or metachronously to invasive squamous cell carcinoma (SCC) in 5% to 10% of cases. The purposes of the present study were to analyze the outcomes of patients with sinonasal SCC arising from inverted papilloma (IP-SCC) treated through an endoscopic approach and review the pertinent literature. METHODS: The medical records of all patients treated for IP-SCC between 1997 and 2014 at 2 referral centers following a uniform policy were retrospectively analyzed...
May 6, 2016: Head & Neck
https://www.readbyqxmd.com/read/27151723/clinical-and-histological-aspects-of-malignant-inverted-sinonasal-papilloma-two-case-reports
#18
Vasile Nicolae, Mariana Sabău, Mihai Iulian FăgeŢan, Vlad Petrescu Seceleanu, Daniel Iorgulescu, Dana Elena Dumitra, Alexandru Dan Sabău, Sorin Ibric-Cioranu, Anca Sava, Viorel Ibric-Cioranu
The inverted sino-nasal papilloma is a benign epithelial lesion, ranging from 1% to 5% of the tumors that reside in this area. It is characterized by a tendency towards local bone destruction, recurrence and malignant transformation. This is a presentation of two cases diagnosed and surgically treated for malignant inverted papiloma, which started in the epithelium of the maxillary sinuses. The cases had in common the late presentation of the patient to the surgeon, thus the local destruction was significant with extension towards the eye socket and the base of the skull...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27138192/immunohistochemical-study-emt-related-proteins-in-hpv-and-ebv-negative-patients-with-sinonasal-tumours
#19
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
Epithelial to mesenchymal transition (EMT) is a biological process in which the epithelial cells, transform to mesenchymal cells via multiple biochemical modifications. Immunohistochemical method was used to examine the expression of EMT-related proteins: Slug, E-cadherin and fibronectin, in 41 cases of sinonasal inverted papilloma (SIP), 33 cases of sinonasal squamous cell carcinoma (SNC), and 22 cases of normal mucosa as a control. In all cases negative viral status was previously confirmed using both in situ hybridization and immunohistochemical method...
October 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27108101/clinical-management-of-squamous-cell-carcinoma-associated-with-sinonasal-inverted-papilloma
#20
Ryuji Yasumatsu, Torahiko Nakashima, Masanobu Sato, Takafumi Nakano, Ryunosuke Kogo, Kazuki Hashimoto, Motohiro Sawatsubashi, Takashi Nakagawa
OBJECTIVE: The aim of this study was to investigate the clinical features and prognosis of patients with squamous cell carcinoma (SCC) associated with sinonasal inverted papilloma (IP). METHODS: The medical records of 95 patients who were diagnosed with IP or SCC associated with IP were retrospectively reviewed. Out of 95 patients, 15 were diagnosed with SCC associated with IP. The clinical characteristics, treatment modalities, and survival outcomes of the patients were analyzed...
April 20, 2016: Auris, Nasus, Larynx
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