Cristiano Schaffer Aguzzoli, Pâmela C L Ferreira, Guilherme Povala, João Pedro Ferrari-Souza, Bruna Bellaver, Carolina Soares Katz, Hussein Zalzale, Firoza Z Lussier, Francieli Rohden, Sarah Abbas, Douglas T Leffa, Marina Scop Medeiros, Joseph Therriault, Andréa L Benedet, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Vanessa Pallen, Ann Cohen, Oscar L Lopez, Dana L Tudorascu, William E Klunk, Victor L Villemagne, Jean Paul Soucy, Eduardo R Zimmer, Lucas P Schilling, Thomas K Karikari, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Victor Valcour, Bruce L Miller, Pedro Rosa-Neto, Tharick A Pascoal
IMPORTANCE: Neuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms. OBJECTIVE: To evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada...
November 1, 2023: JAMA Network Open