keyword
https://read.qxmd.com/read/38255891/the-importance-of-complement-mediated-immune-signaling-in-alzheimer-s-disease-pathogenesis
#21
REVIEW
André F Batista, Khyrul A Khan, Maria-Tzousi Papavergi, Cynthia A Lemere
As an essential component of our innate immune system, the complement system is responsible for our defense against pathogens. The complement cascade has complex roles in the central nervous system (CNS), most of what we know about it stems from its role in brain development. However, in recent years, numerous reports have implicated the classical complement cascade in both brain development and decline. More specifically, complement dysfunction has been implicated in neurodegenerative disorders, such as Alzheimer's disease (AD), which is the most common form of dementia...
January 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38247880/age-dependent-and-a%C3%AE-induced-dynamic-changes-in-the-subcellular-localization-of-hmgb1-in-neurons-and-microglia-in-the-brains-of-an-animal-model-of-alzheimer-s-disease
#22
JOURNAL ARTICLE
Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Lee
HMGB1 is a prototypical danger-associated molecular pattern (DAMP) molecule that co-localizes with amyloid beta (Aβ) in the brains of patients with Alzheimer's disease. HMGB1 levels are significantly higher in the cerebrospinal fluid of patients. However, the cellular and subcellular distribution of HMGB1 in relation to the pathology of Alzheimer's disease has not yet been studied in detail. Here, we investigated whether HMGB1 protein levels in brain tissue homogenates (frontal cortex and striatum) and sera from Tg-APP/PS1 mice, along with its cellular and subcellular localization in those regions, differed...
January 18, 2024: Cells
https://read.qxmd.com/read/38191961/novel-method-for-collecting-hippocampal-interstitial-fluid-extracellular-vesicles-ev-isf-reveals-sex-dependent-changes-in-microglial-ev-proteome-in-response-to-a%C3%AE-pathology
#23
JOURNAL ARTICLE
Morgan C Pait, Sarah D Kaye, Yixin Su, Ashish Kumar, Sangeeta Singh, Stephen C Gironda, Samantha Vincent, Maria Anwar, Caitlin M Carroll, James Andy Snipes, Jingyun Lee, Cristina M Furdui, Gagan Deep, Shannon L Macauley
Brain-derived extracellular vesicles (EVs) play an active role in Alzheimer's disease (AD), relaying important physiological information about their host tissues. The internal cargo of EVs is protected from degradation, making EVs attractive AD biomarkers. However, it is unclear how circulating EVs relate to EVs isolated from disease-vulnerable brain regions. We developed a novel method for collecting EVs from the hippocampal interstitial fluid (ISF) of live mice. EVs (EVISF ) were isolated via ultracentrifugation and characterized by nanoparticle tracking analysis, immunogold labelling, and flow cytometry...
January 2024: Journal of Extracellular Vesicles
https://read.qxmd.com/read/38167557/the-fluorescent-ligand-btvbt2-reveals-increased-p-tau-uptake-by-retinal-microglia-in-alzheimer-s-disease-patients-and-app-nl-f-nl-f-mice
#24
JOURNAL ARTICLE
Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, K Peter R Nilsson, Malin Wennström
BACKGROUND: Amyloid beta (Aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of Alzheimer's disease (AD) patients and transgenic AD mice. Previous studies have shown that retinal microglia engulf Aβ, but this property decreases in AD patients. Whether retinal microglia also take up p-tau and if this event is affected in AD is yet not described. In the current study, we use the p-tau-specific thiophene-based ligand bTVBT2 to investigate the relationship between disease progression and p-tau uptake by microglia in the retina of AD patients and AppNL-F/NL-F knock-in mice, an AD mouse model known to demonstrate extracellular Aβ plaques and dystrophic neurites in the brain from 6 months of age...
January 2, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38159571/an-exhausted-like-microglial-population-accumulates-in-aged-and-apoe4-genotype-alzheimer-s-brains
#25
JOURNAL ARTICLE
Alon Millet, Jose Henrique Ledo, Sohail F Tavazoie
The dominant risk factors for late-onset Alzheimer's disease (AD) are advanced age and the APOE4 genetic variant. To examine how these factors alter neuroimmune function, we generated an integrative, longitudinal single-cell atlas of brain immune cells in AD model mice bearing the three common human APOE alleles. Transcriptomic and chromatin accessibility analyses identified a reactive microglial population defined by the concomitant expression of inflammatory signals and cell-intrinsic stress markers whose frequency increased with age and APOE4 burden...
January 9, 2024: Immunity
https://read.qxmd.com/read/38155736/human-neural-stem-cells-restore-spatial-memory-in-a-transgenic-alzheimer-s-disease-mouse-model-by-an-immunomodulating-mechanism
#26
JOURNAL ARTICLE
Kevin S Chen, Mohamed H Noureldein, Lisa M McGinley, John M Hayes, Diana M Rigan, Jacquelin F Kwentus, Shayna N Mason, Faye E Mendelson, Masha G Savelieff, Eva L Feldman
INTRODUCTION: Stem cells are a promising therapeutic in Alzheimer's disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics to elucidate therapeutic mechanisms of human neural stem cells (hNSCs) in an animal model of AD. METHODS: hNSCs were transplanted into the fimbria fornix of the hippocampus using the 5XFAD mouse model. Spatial memory was assessed by Morris water maze...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38148453/cgas-mediates-the-inflammatory-responses-of-human-microglial-cells-to-genotoxic-dna-damage
#27
JOURNAL ARTICLE
Alexander J Suptela, Yasmine Radwan, Christine Richardson, Shan Yan, Kirill A Afonin, Ian Marriott
Genomic instability is a key driving force for the development and progression of many age-related neurodegenerative diseases and central nervous system (CNS) cancers. Recently, the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), has been shown to detect and respond to self-DNA accumulation resulting from DNA damaging insults in peripheral cell types. cGAS has been shown to be important in the responses of microglia to DNA viruses and amyloid beta, and we have reported that it underlies the responses of human microglia to exogenous DNA...
December 26, 2023: Inflammation
https://read.qxmd.com/read/38146242/moxibustion-influences-hippocampal-microglia-polarization-via-il-33-st2-pathway-in-alzheimer-s-disease-mice
#28
JOURNAL ARTICLE
Hong-Ying Li, Yuan Shen, Lu-Shuang Xie, Qiao-Feng Wu, Shu-Guang Yu
OBJECTIVES: To observe the effect of moxibustion on the polarization of microglia towards M2 direction in Alzheimer's disease (AD) mice through the interleukin-33 (IL-33)/growth stimulating gene 2 protein (ST2) signaling pathway. METHODS: Five-month-old APP/PS1 male mice were randomly divided into model and moxibustion (Moxi) groups, and C57BL/6J mice of the same age were as the control group, with 9 mice in each group. In the Moxi group, moxibustion was applied at "Baihui" (GV20) and "Yongquan" (KI1) for 30 min, once a day, 5 days a week for 4 weeks...
December 25, 2023: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/38144080/improvement-of-key-molecular-events-linked-to-alzheimer-s-disease-pathology-using-postbiotics
#29
JOURNAL ARTICLE
Gabriela Agustina Bulacios, Pablo Gabriel Cataldo, Johana Romina Naja, Elena Posse de Chaves, María Pía Taranto, Carlos Javier Minahk, Elvira María Hebert, María Lucila Saavedra
In the past 50 years, life expectancy has increased by more than 20 years. One consequence of this increase in longevity is the rise of age-related diseases such as dementia. Alzheimer's disease (AD) is the most common form of dementia, accounting for 60-70% of cases. AD pathogenesis is not restricted to the neuronal compartment but includes strong interactions with other brain cells, particularly microglia triggering the release of inflammatory mediators, which contribute to disease progression and severity...
December 19, 2023: ACS Omega
https://read.qxmd.com/read/38137479/bridging-retinal-and-cerebral-neurodegeneration-a-focus-on-crosslinks-between-alzheimer-perusini-s-disease-and-retinal-dystrophies
#30
REVIEW
Luigi Donato, Domenico Mordà, Concetta Scimone, Simona Alibrandi, Rosalia D'Angelo, Antonina Sidoti
In the early stages of Alzheimer-Perusini's disease (AD), individuals often experience vision-related issues such as color vision impairment, reduced contrast sensitivity, and visual acuity problems. As the disease progresses, there is a connection with glaucoma and age-related macular degeneration (AMD) leading to retinal cell death. The retina's involvement suggests a link with the hippocampus, where most AD forms start. A thinning of the retinal nerve fiber layer (RNFL) due to the loss of retinal ganglion cells (RGCs) is seen as a potential AD diagnostic marker using electroretinography (ERG) and optical coherence tomography (OCT)...
December 8, 2023: Biomedicines
https://read.qxmd.com/read/38128884/erythrocyte-membrane-coated-nanocarriers-modified-by-tgn-for-alzheimer-s-disease
#31
JOURNAL ARTICLE
Jinlian Gu, Chang Yan, Shun Yin, Hao Wu, Chi Liu, Ao Xue, Xia Lei, Ning Zhang, Fang Geng
Alzheimer's disease (AD) is an aging-related neurodegenerative disease, and the main pathological feature was β-amyloid protein (Aβ) deposition. Recently, bioactive materials-based drug delivery system has been widely investigated for the treatment of AD. In this study, we developed a red blood cells (RBC) membrane-coated polycaprolactone (PCL) nanoparticles (NPs) loading with a therapeutic agent for AD, curcumin (Cur). A functional peptide TGNYKALHPHN (TGN) was conjugated to the surface of membrane for blood-brain barrier (BBB) transport (TGN-RBC-NPs-Cur)...
December 19, 2023: Journal of Controlled Release
https://read.qxmd.com/read/38104136/translational-profiling-identifies-sex-specific-metabolic-and-epigenetic-reprogramming-of-cortical-microglia-macrophages-in-appps1-21-mice-with-an-antibiotic-perturbed-microbiome
#32
JOURNAL ARTICLE
Shabana M Shaik, Yajun Cao, Joseph V Gogola, Hemraj B Dodiya, Xulun Zhang, Hejer Boutej, Weinong Han, Jasna Kriz, Sangram S Sisodia
BACKGROUND: Microglia, the brain-resident macrophages perform immune surveillance and engage with pathological processes resulting in phenotype changes necessary for maintaining homeostasis. In preceding studies, we showed that antibiotic-induced perturbations of the gut microbiome of APPPS1-21 mice resulted in significant attenuation in Aβ amyloidosis and altered microglial phenotypes that are specific to male mice. The molecular events underlying microglial phenotypic transitions remain unclear...
December 16, 2023: Molecular Neurodegeneration
https://read.qxmd.com/read/38098004/il-17a-promotes-the-progression-of-alzheimer-s-disease-in-app-ps1-mice
#33
JOURNAL ARTICLE
Min Cao, Jing Liu, Xiaomin Zhang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yue Zhao, Peichang Wang
BACKGROUND: Alzheimer's disease (AD), which is the most common cause of dementia in elderly individuals, is a progressive neurodegenerative disorder. Neuroinflammation, which is an immune response that is activated by glial cells in the central nervous system, plays an important role in neurodegenerative diseases. Many studies have shown that interleukin-17A (IL-17A) plays an important role in AD, but research on the pathological effects of IL-17A on AD is limited. METHODS: We report the effect of IL-17A on AD progression in APPswe/PS1dE9 (APP/PS1) mice, which are the most widely used AD model mice...
December 14, 2023: Immunity & Ageing: I & A
https://read.qxmd.com/read/38069392/second-wave-late-stage-neuroinflammation-in-cleared-brains-of-aged-5xfad-alzheimer-s-mice-detected-by-macrolaser-light-sheet-microscopy-imaging
#34
JOURNAL ARTICLE
Suk Hyun Lee, Hye Joo Son
This study leverages the innovative imaging capabilities of macrolaser light-sheet microscopy to elucidate the 3D spatial visualization of AD-associated neuropathologic networks in the transparent brains of 44-week-old 5xFAD mice. Brain samples from ten AD and seven control mice were prepared through a hydrophilic tissue-clearing pipeline and immunostained with thioflavin S (β-amyloid), anti-CD11b antibody (microglia), and anti-ACSA-2 antibody (astrocytes). The 5xFAD group exhibited significantly higher average total surface volumes of β-amyloid accumulation than the control group (AD, 898,634,368 µm3 [383,355,488-1,324,986,752]; control, 33,320,178 µm3 [11,156,785-65,390,988], p = 0...
December 2, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38036733/spatiotemporal-characterization-of-glial-cell-activation-in-an-alzheimer-s-disease-model-by-spatially-resolved-transcriptomics
#35
JOURNAL ARTICLE
Hongyoon Choi, Eun Ji Lee, Jin Seop Shin, Hyun Kim, Sungwoo Bae, Yoori Choi, Dong Soo Lee
The molecular changes that occur with the progression of Alzheimer's disease (AD) are well known, but an understanding of the spatiotemporal heterogeneity of changes in the brain is lacking. Here, we investigated the spatially resolved transcriptome in a 5XFAD AD model at different ages to understand regional changes at the molecular level. Spatially resolved transcriptomic data were obtained from 5XFAD AD models and age-matched control mice. Differentially expressed genes were identified using spots clustered by anatomical structures...
December 1, 2023: Experimental & Molecular Medicine
https://read.qxmd.com/read/38035277/hippocampal-glial-inflammatory-markers-are-differentially-altered-in-a-novel-mouse-model-of-perimenopausal-cerebral-amyloid-angiopathy
#36
JOURNAL ARTICLE
Jimcy Platholi, Roberta Marongiu, Laibaik Park, Fangmin Yu, Garrett Sommer, Rena Weinberger, William Tower, Teresa A Milner, Michael J Glass
Dementia is often characterized by age-dependent cerebrovascular pathology, neuroinflammation, and cognitive deficits with notable sex differences in risk, disease onset, progression and severity. Women bear a disproportionate burden of dementia, and the onset of menopause (i.e., perimenopause) may be a critical period conferring increased susceptibility. However, the contribution of early ovarian decline to the neuroinflammatory processes associated with cerebrovascular dementia risks, particularly at the initial stages of pathology that may be more amenable to proactive intervention, is unknown...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38020773/emerging-alzheimer-s-disease-therapeutics-promising-insights-from-lipid-metabolism-and-microglia-focused-interventions
#37
REVIEW
Nour S Tobeh, Kimberley D Bruce
More than 55 million people suffer from dementia, with this number projected to double every 20 years. In the United States, 1 in 3 aged individuals dies from Alzheimer's disease (AD) or another type of dementia and AD kills more individuals than breast cancer and prostate cancer combined. AD is a complex and multifactorial disease involving amyloid plaque and neurofibrillary tangle formation, glial cell dysfunction, and lipid droplet accumulation (among other pathologies), ultimately leading to neurodegeneration and neuronal death...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38012646/inhibition-of-microfold-cells-ameliorates-early-pathological-phenotypes-by-modulating-microglial-functions-in-alzheimer-s-disease-mouse-model
#38
JOURNAL ARTICLE
Namkwon Kim, In Gyoung Ju, Seung Ho Jeon, Yeongae Lee, Min-Ji Jung, Min Sung Gee, Jae Seok Cho, Kyung-Soo Inn, Lee Ann Garrett-Sinha, Myung Sook Oh, Jong Kil Lee
BACKGROUND: The gut microbiota has recently attracted attention as a pathogenic factor in Alzheimer's disease (AD). Microfold (M) cells, which play a crucial role in the gut immune response against external antigens, are also exploited for the entry of pathogenic bacteria and proteins into the body. However, whether changes in M cells can affect the gut environments and consequently change brain pathologies in AD remains unknown. METHODS: Five familial AD (5xFAD) and 5xFAD-derived fecal microbiota transplanted (5xFAD-FMT) naïve mice were used to investigate the changes of M cells in the AD environment...
November 27, 2023: Journal of Neuroinflammation
https://read.qxmd.com/read/38010651/neuropsychiatric-symptoms-and-microglial-activation-in-patients-with-alzheimer-disease
#39
JOURNAL ARTICLE
Cristiano Schaffer Aguzzoli, Pâmela C L Ferreira, Guilherme Povala, João Pedro Ferrari-Souza, Bruna Bellaver, Carolina Soares Katz, Hussein Zalzale, Firoza Z Lussier, Francieli Rohden, Sarah Abbas, Douglas T Leffa, Marina Scop Medeiros, Joseph Therriault, Andréa L Benedet, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Vanessa Pallen, Ann Cohen, Oscar L Lopez, Dana L Tudorascu, William E Klunk, Victor L Villemagne, Jean Paul Soucy, Eduardo R Zimmer, Lucas P Schilling, Thomas K Karikari, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Victor Valcour, Bruce L Miller, Pedro Rosa-Neto, Tharick A Pascoal
IMPORTANCE: Neuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms. OBJECTIVE: To evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37998347/tonebp-haploinsufficiency-attenuates-microglial-activation-and-memory-deficits-in-middle-aged-and-amyloid-%C3%AE-oligomer-treated-mice
#40
JOURNAL ARTICLE
Jong Youl Lee, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, So Jeong Lee, Hyeong Seok An, Kyung Eun Kim, Won-Ho Kim, Yong Chul Bae, Heeyoung Kang, Gu Seob Roh
Age-related microglial activation is associated with cognitive impairment. Tonicity-responsive enhancer-binding protein (TonEBP) is a critical mediator of microglial activation in response to neuroinflammation. However, the precise role of TonEBP in the middle-aged brain is not yet known. We used TonEBP haploinsufficient mice to investigate the role of TonEBP in middle-aged or amyloid β oligomer (AβO)-injected brains and examined the effect of TonEBP knockdown on AβO-treated BV2 microglial cells...
November 12, 2023: Cells
keyword
keyword
8699
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.