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https://www.readbyqxmd.com/read/29579419/nephrocalcinosis-a-diagnostic-conundrum
#1
Lalathaksha Kumbar, Jerry Yee
No abstract text is available yet for this article.
April 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29430061/biodegradable-polymeric-injectable-implants-for-long-term-delivery-of-contraceptive-drugs
#2
Ohan S Manoukian, Michael R Arul, Naseem Sardashti, Teagan Stedman, Roshan James, Swetha Rudraiah, Sangamesh G Kumbar
Development of injectable, long-lasting, contraceptive drug delivery formulations and implants are highly desired to avoid unplanned pregnancies while improving patient compliance and reducing adverse side effects and treatment costs. The present study reports on the fabrication and characterization of two levonorgestrel (LNG) microsphere injectable formulations. Poly(ε-caprolactone) (PCL) with 12.5% and 24% (w/w) LNG were fabricated into microspheres, measuring 300±125 μm, via the oil-in-water (o/w) emulsion solvent evaporation technique...
April 2018: Journal of Applied Polymer Science
https://www.readbyqxmd.com/read/29400328/synthesis-crystal-structure-and-biological-properties-of-a-cis-dichloridobis-diimine-copper-ii-complex
#3
Satish S Bhat, Vidyanand K Revankar, Vijay Kumbar, Kishore Bhat, Vitthal A Kawade
The mechanisms of interaction of inorganic complexes with DNA are important in the design and development of new metal-based drug molecules. The limitations of cis-platin have encouraged the design and development of new metal-based target-specific anticancer drugs having reduced side effects. The complex cis-dichloridobis(1,2,5-thiadiazolo[3,4-f][1,10]phenanthroline-κ2N1,N10)copper(II), [CuCl2(C12H6N4S)2], has been synthesized and characterized. The complex crystallizes in the monoclinic space group C2/c...
February 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29178402/micro-nanostructures-of-cellulose-collagen-for-critical-sized-bone-defect-healing
#4
Aja Aravamudhan, Daisy M Ramos, Jonathan Nip, Ivo Kalajzic, Sangamesh G Kumbar
Bone tissue engineering strategies utilize biodegradable polymeric matrices alone or in combination with cells and factors to provide mechanical support to bone, while promoting cell proliferation, differentiation, and tissue ingrowth. The performance of mechanically competent, micro-nanostructured polymeric matrices, in combination with bone marrow stromal cells (BMSCs), is evaluated in a critical sized bone defect. Cellulose acetate (CA) is used to fabricate a porous microstructured matrix. Type I collagen is then allowed to self-assemble on these microstructures to create a natural polymer-based, micro-nanostructured matrix (CAc)...
February 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29151986/pyrrolyl-pyrazoline-carbaldehydes-as-enoyl-acp-reductase-inhibitors-design-synthesis-and-antitubercular-activity
#5
Sheshagiri R Dixit, Shrinivas D Joshi, Venkatarao H Kulkarni, Sunil S Jalalpure, Vijay M Kumbar, Tulasigiriyappa Y Mudaraddi, Mallikarjuna N Nadagouda, Tejraj M Aminabhavi
Introduction: In efforts to develop new antitubercular (anti-TB) compounds, herein we describe cytotoxic evaluation of 15 newly synthesized pyrrolyl pyrazoline carbaldehydes. Method & Materials: Surflex-Docking method was used to study binding modes of the compounds at the active site of the enzyme enoyl ACP reductase from Mycobacterium tuberculosis (M. tuberculosis) , which plays an important role in FAS-II biosynthetic pathway of M. tuberculosis and also it is an important target for designing novel anti-TB agents...
2017: Open Medicinal Chemistry Journal
https://www.readbyqxmd.com/read/29105763/synthesis-photophysical-and-computational-study-of-novel-coumarin-based-organic-dyes
#6
Mahadev N Kumbar, Madivalagouda S Sannaikar, Saba Kauser J Shaikh, Atulkumar A Kamble, Manjunath N Wari, Sanjeev R Inamdar, Qiquan Qiao, N R Bhavya, M Mahendra, D Jagadeesh Prasad, Ravindra R Kamble
A series of novel coumarin pyrazoline moieties combined with tetrazoles, 3-(1-phenyl-4-(1H-tetrazol-5-yl)-1H-pyrazol-3-yl)-2H-chromen-2-one, 6-chloro-3-(1-phenyl-4-(1H-tetrazol-5-yl)-1H-pyrazol-3-yl)-2H-chromen-2-one, 6-bromo-3-(1-phenyl-4-(1H-tetrazol-5-yl)-1H-pyrazol-3-yl)-2H-chromen-2-one and 6-bromo-3-(1-(4-bromophenyl)-4-(1H-tetrazol-5-yl)-1H pyrazol-3-yl)-2H-chromen-2-one 7(a-d) were designed and synthesized. Single crystal X-ray diffraction and their interactions were studied by Hirshfeld Surface Analysis...
November 6, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28961475/synthesis-structural-characterization-and-biological-properties-of-phosphorescent-iridium-iii-complexes
#7
Satish S Bhat, Naveen Shivalingegowda, Vidyanand K Revankar, N K Lokanath, Manohar S Kugaji, Vijay Kumbar, Kishore Bhat
Two phosphorescent cyclometalated iridium(III)-triptycenyl-1,10-phenanthroline complexes [Ir(ppy)2 (tpt-phen)]+ (1) and [Ir(bhq)2 (tpt-phen)]+ (2) {ppy=2-phenylpyridine, bhq=Benzo[h]quinoline, tpt-phen=triptycenyl-1,10-phenanthroline} have been synthesized and structurally characterized. The structure of complex 2 has been studied by single crystal X-ray crystallography. The photophysical properties of complexes in a different solvent have also been investigated. The binding of complexes to the double stranded calf thymus (CT-DNA) has been investigated by spectroscopic techniques...
December 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28653043/bioactive-polymeric-scaffolds-for-tissue-engineering
#8
Scott Stratton, Namdev B Shelke, Kazunori Hoshino, Swetha Rudraiah, Sangamesh G Kumbar
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo . Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity...
December 2016: Bioactive Materials
https://www.readbyqxmd.com/read/28462147/in-vitro-antioxidant-and-anticancer-activity-of-leea-indica-leaf-extracts-on-human-prostate-cancer-cell-lines
#9
REVIEW
Shridhar C Ghagane, Sridevi I Puranik, Vijay M Kumbar, Rajendra B Nerli, Sunil S Jalalpure, Murigendra B Hiremath, Shivayogeeswar Neelagund, Ravindranath Aladakatti
BACKGROUND: To determine the phytochemical constituents, antioxidant, and anticancer activities of Leea indica leaf extracts on DU-145 and PC-3 human prostate cancer cell lines. METHODS: Leaf sample was subjected to Soxhlet extraction method with increasing polarity of solvents, namely, chloroform, ethyl acetate, methanol, ethanol, and aqueous. Phytochemical screening was done using different biochemical tests. Quantitative analysis for phenol was determined by Folin-Ciocalteu reagent method...
March 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/28369135/engineered-stem-cell-niche-matrices-for-rotator-cuff-tendon-regenerative-engineering
#10
M Sean Peach, Daisy M Ramos, Roshan James, Nicole L Morozowich, Augustus D Mazzocca, Steven B Doty, Harry R Allcock, Sangamesh G Kumbar, Cato T Laurencin
Rotator cuff (RC) tears represent a large proportion of musculoskeletal injuries attended to at the clinic and thereby make RC repair surgeries one of the most widely performed musculoskeletal procedures. Despite the high incidence rate of RC tears, operative treatments have provided minimal functional gains and suffer from high re-tear rates. The hypocellular nature of tendon tissue poses a limited capacity for regeneration. In recent years, great strides have been made in the area of tendonogenesis and differentiation towards tendon cells due to a greater understanding of the tendon stem cell niche, development of advanced materials, improved scaffold fabrication techniques, and delineation of the phenotype development process...
2017: PloS One
https://www.readbyqxmd.com/read/28262527/quinoline-azetidinone-hybrids-synthesis-and-in-vitro-antiproliferation-activity-against-hep-g2-and-hep-3b-human-cell-lines
#11
S G Alegaon, P Parchure, L D Araujo, P S Salve, K R Alagawadi, S S Jalalpure, V M Kumbar
In search of new heterocyclic anticancer agents, a new quinoline-azetidinone hybrid template have been designed, synthesized and screened for their cytotoxic activity against human cancer cell lines such as Hep G2, and Hep 3B by the MTT assay and results were compared with paclitaxel, 5-fluorouracil and doxorubicin. Interestingly, some of the compounds were found significantly active against both cell lines. The compound 6f (IC50 =0.04±0.01µM) exhibited potent antiproliferation activity against Hep G2 cell line, and 6j compound (IC50 =0...
April 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28238143/electrospun-nanofiber-scaffolds-and-their-hydrogel-composites-for-the-engineering-and-regeneration-of-soft-tissues
#12
Ohan S Manoukian, Rita Matta, Justin Letendre, Paige Collins, Augustus D Mazzocca, Sangamesh G Kumbar
Electrospinning has emerged as a simple, elegant, and scalable technique that can be used to fabricate polymeric nanofibers. Pure polymers as well as blends and composites of both natural and synthetic ones have been successfully electrospun into nanofiber matrices for many biomedical applications. Tissue-engineered medical implants, such as polymeric nanofiber scaffolds, are potential alternatives to autografts and allografts, which are short in supply and carry risks of disease transmission. These scaffolds have been used to engineer various soft tissues, including connective tissues, such as skin, ligament, and tendon, as well as nonconnective ones, such as vascular, muscle, and neural tissue...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28207605/ultrasound-guided-fenestration-of-the-carpal-ligament-using-a-double-needle-approach
#13
Gloria E Hwang, Sanjay Kumbar, Todd Stitik, John S Georgy, Hoss Hanna
Injection techniques for carpal tunnel syndrome have evolved from landmark palpation injection techniques to more accurate ultrasound-guided approaches. Presented is a case report describing a technique serendipitously discovered during a carpal ligament fenestration. The case involved a 66-year-old man with a diagnosis of carpal tunnel syndrome. After a failed attempt at treatment using a wrist splint and activity modification, he was treated by median nerve hydrodissection with 100% temporary pain relief...
October 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28157278/evaluating-the-success-of-interventions-on-the-compromised-access
#14
Lalathaksha Kumbar
No abstract text is available yet for this article.
August 2016: Nephrology News & Issues
https://www.readbyqxmd.com/read/28067467/coronal-mode-ultrasound-guided-hemodialysis-cannulation-a-pilot-randomized-comparison-with-standard-cannulation-technique
#15
Lalathaksha Kumbar, Vivek Soi, Elizabeth Adams, Cheryl Brown Deacon, Mohamed Zidan, Jerry Yee
Background Infiltrations from cannulation result in significant morbidity including loss of hemodialysis (HD) vascular access (VA). Cannulation is dependent on personnel skill and VA characteristics. Surface marking of VA lacks real-time information and traditional ultrasound (US) devices are large, expensive, requiring skilled operators. Sonic Window© (Analogic Ultrasound, Peabody, MA, USA) is a coronal mode ultrasound device (CMUD) approved for VA cannulation. Methods Single center randomized, prospective pilot study comparing handheld US-guided cannulation of new arteriovenous fistula (AVF) to standard cannulation practices...
January 9, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28050374/infectious-granulomatous-dermatitis-at-a-tertiary-care-centre-in-north-maharashtra-a-histopathological-study
#16
Rajeshwari Kumbar, Nandkumar Dravid, Karibasappa Gundabaktha Nagappa, Chakor Rokade
INTRODUCTION: Infectious granulomatous dermatitis is a distinctive entity of chronic inflammation. Recognizing the aetiology of granulomatous lesion is challenging to the dermatopathologist. The definitive diagnosis of the granulomatous lesions of skin with identification of aetiological agent is very essential for specific treatment and an appropriate desirable outcome. AIM: To study the histomorphology of various granulomatous lesions of skin and classify them, accordingly into different categories...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891020/preventing-medico-legal-issues-in-clinical-practice
#17
REVIEW
Bevinahalli N Raveesh, Ragavendra B Nayak, Shivakumar F Kumbar
The medical profession is considered to be one of the noblest professions in the world. The practice of medicine is capable of rendering noble service to humanity provided due care, sincerity, efficiency, and professional skill is observed by the doctors. However, today, the patient-doctor relationship has almost diminished its fiduciary character and has become more formal and structured. Doctors are no longer regarded as infallible and beyond questioning. Corporatization of health care has made it like any other business, and the medical profession is increasingly being guided by the profit motive rather than that of service...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27693961/molecular-and-cellular-effects-of-vitamin-b12-forms-on-human-trophoblast-cells-in-presence-of-excessive-folate
#18
COMPARATIVE STUDY
Tejas Shah, Kalpana Joshi, Sanjay Mishra, Suhas Otiv, Vijay Kumbar
Folic acid (FA) and iron are essential supplements during pregnancy. Similarly effects of vitamin B12 (B12) inadequacy and high folate and low B12 status, on pregnancy outcome are available. However there are no mandatory recommendations for B12. There are many forms of B12 viz. Cyanocobalamin (Cbl), Methylcobalamin (MeCbl), Adenosylcobalamin (AdCbl), and Hydroxycobalamin (HCbl) though there is limited consensus on which form has better efficacy. In the present study we have determined effect of various forms of B12 in the presence of two FA concentrations namely normal physiological (20ng/mL; NPFA) and supra-physiological (2000ng/mL; SPFA) concentration to mimic real time situation where FA is in excess due to supplementation...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27383137/improving-coccyx-radiographs-in-emergency-departments
#19
Patrick M Foye, Sanjay Kumbar, Charles Koon
No abstract text is available yet for this article.
July 6, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27349593/poly-lactic-acid-for-delivery-of-bioactive-macromolecules
#20
REVIEW
Roshan James, Ohan S Manoukian, Sangamesh G Kumbar
Therapeutic biomolecules often require frequent administration and supramolecular dosing to achieve therapeutic efficiencies and direct infusion into treatment or defect sites results in inadequate physiological response and at times severe side effects or mis-targeting. Delivery systems serve several purposes such as increased circulatory time, increased biomolecule half-life, and incorporation of new innovations can enable highly specific cell targeting and improved cell and nucleus permeability. Poly(lactic acid) (PLA) has become a "material of choice" due to wide availability, reproducible synthetic route, customization, versatility, biodegradability and biocompatibility...
December 15, 2016: Advanced Drug Delivery Reviews
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