Stefan Herzig, Ismail F Y Khan, Dirk Gründemann, Jan Matthes, Andreas Ludwig, Guido Michels, Uta C Hoppe, Dipayan Chaudhuri, Arnold Schwartz, David T Yue, Roger Hullin
L-type calcium channels are composed of a pore, alpha1c (Ca(V)1.2), and accessory beta- and alpha2delta-subunits. The beta-subunit core structure was recently resolved at high resolution, providing important information on many functional aspects of channel modulation. In this study we reveal differential novel effects of five beta2-subunits isoforms expressed in human heart (beta(2a-e)) on the single L-type calcium channel current. These splice variants differ only by amino-terminal length and amino acid composition...
May 2007: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology