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carboxymethyllysine

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https://www.readbyqxmd.com/read/28415841/unique-pattern-of-protein-bound-maillard-reaction-products-in-manuka-leptospermum-scoparium-honey
#1
Michael Hellwig, Jana Rückriemen, Daniel Sandner, Thomas Henle
As a unique feature, honey from the New Zealand manuka tree (Leptospermum scoparium) contains substantial amounts of dihydroxyacetone (DHA) and methylglyoxal (MGO). Although MGO is a reactive intermediate in the Maillard reaction, very little is known about reactions of MGO with honey proteins. We hypothesized that the abundance of MGO should result in a particular pattern of protein-bound Maillard reaction products (MRPs) in manuka honey. A protein-rich high-molecular-weight fraction was isolated from 12 manuka and 8 non-manuka honeys and hydrolyzed enzymatically...
April 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28353655/effects-of-two-different-dietary-patterns-on-inflammatory-markers-advanced-glycation-end-products-and-lipids-in-subjects-without-type-2-diabetes-a-randomised-crossover-study
#2
Yoona Kim, Jennifer B Keogh, Peter M Clifton
Epidemiological studies suggest that consumption of red and processed meat and refined grains are associated with type 2 diabetes and metabolic syndrome and increased inflammatory and fibrinolytic markers. We hypothesised that a diet high in red and processed meat and refined grains (HMD) would increase inflammatory markers and advanced glycation end products (AGEs) compared with a diet high in dairy, whole grains, nuts and legumes (HWD). We performed a randomised crossover study of two four-week interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35...
March 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28336820/an-advanced-glycation-endproduct-age-rich-diet-promotes-accumulation-of-ages-in-achilles-tendon
#3
Dorthe Skovgaard, Rene B Svensson, Jean Scheijen, Pernilla Eliasson, Pernille Mogensen, Anne Mette F Hag, Michael Kjær, Casper G Schalkwijk, Peter Schjerling, Stig P Magnusson, Christian Couppé
Advanced Glycation Endproducts (AGEs) accumulate in long-lived tissue proteins like collagen in bone and tendon causing modification of the biomechanical properties. This has been hypothesized to raise the risk of orthopedic injury such as bone fractures and tendon ruptures. We evaluated the relationship between AGE content in the diet and accumulation of AGEs in weight-bearing animal Achilles tendon. Two groups of mice (C57BL/6Ntac) were fed with either high-fat diet low in AGEs high-fat diet (HFD) (n = 14) or normal diet high in AGEs (ND) (n = 11)...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28299531/formation-of-pentosidine-cross-linking-in-myoglobin-by-glyoxal-detection-of-fluorescent-advanced-glycation-end-product
#4
Sauradipta Banerjee
Glyoxal, a reactive α-oxoaldehyde, increases in diabetic condition and reacts with proteins to form advanced glycation end products (AGEs) following Maillard-like reaction. Considering the significance of protein modification by glyoxal-derived AGEs, we investigated the in vitro effect of glyoxal (200 μM) on the monomeric heme protein myoglobin (Mb) (100 μM) after incubation for one week at 25 °C. Glyoxal-treated Mb exhibited increased absorbance around the Soret region, decreased α-helicity and thermal stability compared to control Mb...
March 15, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28290298/evaluation-of-an-olive-leaf-extract-as-a-natural-source-of-antiglycative-compounds
#5
Marta Navarro, Francisco J Morales
Advanced Glycation End-products (AGEs) have been associated to diabetes, neurodegenerative and cardiovascular diseases. Mitigating the formation of AGEs is a strategy to avoid detrimental physiopathological effects of age-related chronic diseases. An olive leaf extract (OLE), obtained under acidic conditions, and two fractions, obtained by solid-phase extraction, were characterized by LC-MS/MS. Antiglycative capacity of OLE and fractions were investigated in different in vitro models. The OLE significantly inhibited the formation of Amadori products at the early stage as well as the formation of fluorescent AGEs at the advanced stage of the glycation...
February 2017: Food Research International
https://www.readbyqxmd.com/read/28280052/cross-sectional-analysis-of-age-cml-srage-and-esrage-with-diabetes-and-cardiometabolic-risk-factors-in-a-community-based-cohort
#6
MULTICENTER STUDY
Stephanie J Loomis, Yuan Chen, David B Sacks, Eric S Christenson, Robert H Christenson, Casey M Rebholz, Elizabeth Selvin
BACKGROUND: Advanced glycation end products (AGEs) and their receptors are regarded as central to the development of diabetic complications, but associations with diabetes and cardiometabolic outcomes in previous studies are mixed. METHODS: Using ELISA assays, we measured N(6)-carboxymethyllysine (AGE-CML), soluble receptor for AGEs (sRAGE), and endogenous secreted receptor for AGEs (esRAGE) in 1874 participants from the Atherosclerosis Risk in Communities study...
May 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27900834/transformation-of-free-and-dipeptide-bound-glycated-amino-acids-by-two-strains-of-saccharomyces-cerevisiae
#7
Michael Hellwig, Marie Börner, Falco Beer, Karl-Heinz van Pée, Thomas Henle
The yeast Saccharomyces cerevisiae transforms branched-chain and aromatic amino acids into higher alcohols in the Ehrlich pathway. During microbiological culturing and industrial fermentations, this yeast is confronted with amino acids modified by reducing sugars in the Maillard reaction (glycation). In order to gain some preliminary insight into the physiological "handling" of glycated amino acids by yeasts, individual Maillard reaction products (MRPs: fructosyllysine, carboxymethyllysine, pyrraline, formyline, maltosine, methylglyoxal-derived hydroimidazolone) were administered to two strains of S...
February 1, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27805212/antioxidant-balance-and-accumulation-of-advanced-glycation-end-products-after-the-consumption-of-standard-diets-including-maillard-reaction-products-from-silver-carp-peptides
#8
Ye Yao, Kaining Han, Shiyuan Dong, Mingyong Zeng, Zunying Liu
The aim of this research was to investigate the accumulation and excretion of AGEs including fluorescent compounds and N-ε-carboxymethyllysine (CML) in streptozotocin-induced diabetes C57BL/6J mice fed on a diet containing Maillard reaction products (MRPs) from a silver carp peptide-glucose model system at different heating temperatures for the first time, and analyze the relationship between their in vitro antioxidant activity based on DPPH and ORAC assays and in vivo oxidative stress. The in vitro antioxidant activity of MRPs positively correlated with their AGEs level and molecular weight distribution...
November 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27771957/simultaneous-quantitation-of-advanced-glycation-end-products-in-soy-sauce-and-beer-by-liquid-chromatography-tandem-mass-spectrometry-without-ion-pair-reagents-and-derivatization
#9
Yuri Nomi, Hironori Annaka, Shinji Sato, Etsuko Ueta, Tsuyoshi Ohkura, Kazuhiro Yamamoto, Seiichi Homma, Emiko Suzuki, Yuzuru Otsuka
The aim of this study was to develop a simple and sensitive method to analyze several advanced glycation end products (AGEs) simultaneously using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and to apply this method to the quantitation of AGEs in brown-colored foods. The developed method enabled to separate and quantitate simultaneously seven AGEs, and was applied to the determination of free AGEs contained in various kinds of soy sauce and beer. The major AGEs in soy sauce and beer were N(ε)-carboxymethyllysine (CML), N(ε)-carboxyethyllysine (CEL), and N(δ)-(5-hydro-5-methyl-4-imidazolon-2-yl)ornithine (MG-H1)...
November 9, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27520463/stress-responses-of-human-retinal-pigment-epithelial-cells-to-glyoxal
#10
Cora Roehlecke, Monika Valtink, Annika Frenzel, Doris Goetze, Lilla Knels, Henning Morawietz, Richard H W Funk
PURPOSE: Intracellular formation of advanced glycation end products (AGEs) is a crucial pathological process in retinal diseases such as age-related macular degeneration (AMD) or diabetic retinopathy (DR). Glyoxal is a physiological metabolite produced during formation of AGEs and has also been shown to derive from photodegraded bisretinoid fluorophores in aging retinal pigment epithelial (RPE) cells. METHODS: Flow cytometry was combined with either: 1) immunocytochemical staining to detect glyoxal induced formation of N(ε)-carboxymethyllysine (CML)-modifications of intracellular proteins (AGEs) and changes in the production of stress response proteins; or 2) vital staining to determine apoptosis rates (annexin V binding), formation of intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and changes in intracellular pH upon treatment of cells with glyoxal...
December 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27517907/advanced-glycation-end-products-enhance-lung-cancer-cell-invasion-and-migration
#11
Te-Chun Hsia, Mei-Chin Yin, Mei-Chin Mong
Effects of carboxymethyllysine (CML) and pentosidine, two advanced glycation end-products (AGEs), upon invasion and migration in A549 and Calu-6 cells, two non-small cell lung cancer (NSCLC) cell lines were examined. CML or pentosidine at 1, 2, 4, 8 or 16 μmol/L were added into cells. Proliferation, invasion and migration were measured. CML or pentosidine at 4-16 μmol/L promoted invasion and migration in both cell lines, and increased the production of reactive oxygen species, tumor necrosis factor-α, interleukin-6 and transforming growth factor-β1...
August 9, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27513747/antiglycation-and-antioxidant-properties-of-momordica-charantia
#12
Ali Aljohi, Sabine Matou-Nasri, Nessar Ahmed
The accumulation of advanced glycation endproducts (AGEs) and oxidative stress underlie the pathogenesis of diabetic complications. In many developing countries, diabetes treatment is unaffordable, and plants such as bitter gourd (or bitter melon; Momordica charantia) are used as traditional remedies because they exhibit hypoglycaemic properties. This study compared the antiglycation and antioxidant properties of aqueous extracts of M. charantia pulp (MCP), flesh (MCF) and charantin in vitro. Lysozyme was mixed with methylglyoxal and 0-15 mg/ml of M...
2016: PloS One
https://www.readbyqxmd.com/read/27434539/the-age-rage-axis-and-its-relationship-to-markers-of-cardiovascular-disease-in-newly-diagnosed-diabetic-patients
#13
Ma Etzabel Villegas-Rodríguez, Jaime Uribarri, Sergio E Solorio-Meza, Martha E Fajardo-Araujo, Weijing Cai, Sofía Torres-Graciano, Rubén Rangel-Salazar, Kazimierz Wrobel, Ma Eugenia Garay-Sevilla
AIM: The purpose of the study was the simultaneous measurement of all the different components of the AGE-RAGE axis as well as several non-invasive markers of cardiovascular disease (CVD) in a cohort of newly diagnosed diabetic patients. MATERIALS AND METHODS: In 80 newly diagnosed diabetic patients we measured serum carboxymethyllysine (CML), soluble RAGE (sRAGE) and peripheral mononuclear (PMNC) RAGE and AGER1 mRNA together with ICAM-1, VCAM-1, and malondialdehyde (MDA)...
2016: PloS One
https://www.readbyqxmd.com/read/27393741/quantitative-assessment-of-organ-distribution-of-dietary-protein-bound-13-c-labeled-n-%C3%A9-carboxymethyllysine-after-a-chronic-oral-exposure-in-mice
#14
Frédéric J Tessier, Céline Niquet-Léridon, Philippe Jacolot, Céline Jouquand, Michaël Genin, Ann-Marie Schmidt, Nicolas Grossin, Eric Boulanger
SCOPE: N(ɛ) -Carboxymethyl-lysine (CML) is a prominent advanced glycation end-product which is not only found in vivo but also in food. It is known that a percentage of the dietary CML (dCML) is absorbed into the circulation and only partly excreted in the urine. Several studies have tried to measure how much dCML remains in tissues. However obstacles to interpreting the data have been found. METHODS AND RESULTS: A new protocol which discriminates dCML from native CML (nCML) has been developed...
July 9, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27387241/determination-of-advanced-glycation-end-products-and-antibodies-against-them-anti-cml-and-anti-cel-in-the-serum-of-graves-orbitopathy-patients-before-and-after-methylprednisolone-treatment
#15
Janusz Strzelczyk, Magdalena Szumska, Aleksandra Damasiewicz-Bodzek, Anna Krywult, Michał Długaszek, Justyna Czubilińska, Kaja Gawlik, Konrad Synowiec, Krystyna Tyrpień-Golder, Karolina Poczkaj, Beata Kos-Kudła
INTRODUCTION: The glycation process is a non-enzymatic modification of proteins occurring due to the reactions of reductive carbohydrates. The glycated residues lose their biological functions, and their removal process is ineffective. They accumulate, and as a result they cause an immunological response. The aim of this study was a determination of the concentrations of advanced glycation end-products and antibodies against carboxymethyl lysine (anti-CML) and carboxyethyl lysine (anti-CEL) in the sera of Graves' orbitopathy patients...
2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27283604/development-and-applications-of-molecularly-imprinted-polymers-based-on-hydrophobic-cdse-zns-quantum-dots-for-optosensing-of-n-%C3%AE%C2%B5-carboxymethyllysine-in-foods
#16
Huilin Liu, Dan Wu, Kaiwen Zhou, Jing Wang, Baoguo Sun
A novel molecularly imprinted polymer (MIP) based on hydrophobic CdSe/ZnS quantum dots (HBQDs) was synthesized via an approach that combines MIPs for the selectivity and sensitivity with semiconductor HBQDs as optosensing material (HBQDs@MIP). Here, using a one-pot water-in-oil reverse microemulsion polymerization, the HBQDs@MIP was used as a molecular recognition element to construct an N(ε)-carboxymethyllysine (CML) optosensor. The HBQDs were coated with silica to endow the nanoparticles with high dispersibility and broad compatibility with hydrophilic analytes...
November 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27237139/application-of-quantum-dot-molecularly-imprinted-polymer-core-shell-particles-sensitized-with-graphene-for-optosensing-of-n-%C3%AE%C2%B5-carboxymethyllysine-in-dairy-products
#17
Huilin Liu, Xiaomo Chen, Lin Mu, Jing Wang, Baoguo Sun
Hydrophobic CdSe/ZnS quantum dots (QDs) coated with a molecularly imprinted polymer (MIP) sensitized with graphene (Gra-QDs@MIP) were prepared through a one-pot reverse microemulsion polymerization at room temperature. Gra-QDs@MIP was used as a molecular recognition element to construct a N(ε)-carboxymethyllysine (CML) optosensor. Graphene was used as a polymerization platform to increase the stability and kinetic binding properties of the system. Reverse microemulsion polymerization can anchor silica spheres on the surface of the QDs...
June 15, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27193019/a-retrospective-study-in-adults-with-metabolic-syndrome-diabetic-risk-factor-response-to-daily-consumption-of-agaricus-bisporus-white-button-mushrooms
#18
Mona S Calvo, Anita Mehrotra, Robert B Beelman, Girish Nadkarni, Lingzhi Wang, Weijing Cai, Boon Cher Goh, Michael D Kalaras, Jaime Uribarri
Adults with metabolic syndrome from different race/ethnicities are often predisposed to developing type 2 diabetes (T2D); however, growing evidence suggests that healthy diets and lifestyle choices can significantly slow or prevent progression to T2D. This poorly understood relationship to healthy dietary patterns and prevention of T2D motivated us to conduct a retrospective analysis to determine the potential impact of a minor dietary lifestyle change (daily mushroom consumption) on known T2D risk factors in racially diverse adults with confirmed features of the metabolic syndrome...
September 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27170482/n-carboxymethyllysine-as-a-biomarker-for-coronary-artery-disease-and-age-related-macular-degeneration
#19
Daiva Stanislovaitienė, Dalia Žaliūnienė, Rasa Steponavičiūtė, Reda Žemaitienė, Olivija Gustienė, Remigijus Žaliūnas
BACKGROUND AND OBJECTIVE: An association between coronary artery disease (CAD) and age-related macular degeneration (ARMD) has long been postulated, but exact mechanisms remain unclear. The global prevalence of CAD and ARMD increases and early biomarkers for early diagnosis of these diseases are necessary. The aim of this study was to investigate the plasma level of oxidative stress biomarker CML in patients with and without angiographic findings of atherosclerosis in the coronary arteries (CADath+ and CADath-, respectively) and to assess if there was an association of CAD with ARMD...
2016: Medicina
https://www.readbyqxmd.com/read/27137869/n-%C3%AF%C2%B5-carboxymethyllysine-increases-the-expression-of-mir-103-143-and-enhances-lipid-accumulation-in-3t3-l1-cells
#20
Ann-Katrin Holik, Barbara Lieder, Nicole Kretschy, Mark M Somoza, Sandra Held, Veronika Somoza
Advanced glycation endproducts, formed in vivo, but also by the Maillard reaction upon thermal treatment of foods, have been associated with the progression of pathological conditions such as diabetes mellitus. In addition to the accumulation with age, exogenous AGEs are introduced into the circulation from dietary sources. In this study, we investigated the effects of addition of free N(ϵ) -carboxymethyllysine (CML), a well-characterized product of the Maillard reaction, on adipogenesis in 3T3-L1 preadipocytes...
October 2016: Journal of Cellular Biochemistry
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