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carboxymethyllysine

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https://www.readbyqxmd.com/read/29625216/receptor-for-advanced-glycation-end-products-rage-is-expressed-predominantly-in-medium-spiny-neurons-of-tghd-rat-striatum
#1
Dian Shi, Joshua W H Chang, Jaimin Choi, Bronwen Connor, Simon O'Carroll, Louise F B Nicholson, Joo Hyun Kim
Receptor for advanced glycation end products (RAGE) is a multi-ligand receptor involved in the pathology of several progressive neurodegenerative disorders including Huntington's disease (HD). We previously showed that the expression of RAGE and its colocalization with ligands were increased in the striatum of HD patients, increasing with grade severity, and that the pattern of RAGE expression coincided with the medio-lateral pattern of neurodegeneration. However, the exact role of RAGE in HD remains elusive...
April 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29533466/the-advanced-glycation-endproduct-n-%C3%AE%C2%B5-carboxymethyllysine-promotes-progression-of-pancreatic-cancer-implications-for-diabetes-associated-risk-and-its-prevention
#2
Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Vittoria Ionta, Claudia Blasetti Fantauzzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio, Giuseppe Pugliese
Diabetes is an established risk factor for pancreatic cancer (PaC), together with obesity, Western diet and tobacco smoking. The common mechanistic link might be the accumulation of advanced glycation endproducts (AGEs), which characterizes all the above disease conditions and unhealthy habits. Surprisingly, however, the role of AGEs in PaC has not been examined yet, despite the evidence of a tumor-promoting role of RAGE, the receptor for AGEs. Here, we tested the hypothesis that AGEs promote PaC through RAGE activation...
March 13, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29479038/effects-of-long-term-cadmium-exposure-on-urinary-metabolite-profiles-in-mice
#3
Sailendra Nath Sarma, Ammar Saleem, Jin-Yong Lee, Maki Tokumoto, Gi-Wook Hwang, Hing Man Chan, Masahiko Satoh
Cadmium (Cd) is a common environmental pollutant with known toxic effects on the kidney. Urinary metabolomics is a promising approach to study mechanism by which Cd-induced nephrotoxicity. The aim of this study was to elucidate the mechanism of Cd toxicity and to develop specific biomarkers by identifying urinary metabolic changes after a long-term of Cd exposure and with the critical concentration of Cd in the kidney. Urine samples were collected from wild-type 129/Sv mice after 67 weeks of 300 ppm Cd exposure and analyzed by ultra performance liquid chromatography connected with quadrupole time of flight mass spectrometer (UPLC-QTOF-MS) based metabolomics approach...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29422652/rage-aptamer-attenuates-deoxycorticosterone-acetate-salt-induced-renal-injury-in-mice
#4
Kensei Taguchi, Sho-Ichi Yamagishi, Miyuki Yokoro, Sakuya Ito, Goh Kodama, Yusuke Kaida, Yosuke Nakayama, Ryotaro Ando, Nana Yamada-Obara, Katsuhiko Asanuma, Takanori Matsui, Yuichiro Higashimoto, Craig R Brooks, Seiji Ueda, Seiya Okuda, Kei Fukami
The mineralocorticoid receptor (MR) and its downstream signaling play an important role in hypertensive renal injury. The interaction of advanced glycation end products (AGE) with their receptor (RAGE) is involved in the progression of renal disease. However, the pathological crosstalk between AGE-RAGE axis and MR system in kidney derangement remains unclear. We screened DNA-aptamer directed against RAGE (RAGE-apt) in vitro and examined its effects on renal injury in uninephrectomized deoxycorticosterone acetate (DOCA)/salt-induced hypertensive mice...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420566/a-novel-monoclonal-antibody-targeting-carboxymethyllysine-an-advanced-glycation-end-product-in-atherosclerosis-and-pancreatic-cancer
#5
Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt
Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function. The resulting modifications induce inflammation by binding to scavenger receptors. An increase in advanced glycation end products is observed in a number of diseases e.g. atherosclerosis and cancer. Since advanced glycation end products also are present in healthy individuals, their detection and quantification are of great importance for usage as potential biomarkers...
2018: PloS One
https://www.readbyqxmd.com/read/29414239/effects-of-highland-barley-bran-extract-rich-in-phenolic-acids-on-the-formation-of-n%C3%AE%C2%B5-carboxymethyllysine-in-a-biscuit-model
#6
Huilin Liu, Xiaomo Chen, Dianwei Zhang, Jing Wang, Shuo Wang, Baoguo Sun
Highland barley, a staple food in northwest China, is a well-known source of bioactive phytochemicals, including phenolic compounds. This study evaluated the inhibitory effects of highland barley bran extracts (HBBE) on the advanced glycation end products (AGEs) levels in a biscuit model, as measured by Nε-carboxymethyllysine (CML) contents. CML was detected in all inhibition models using HBBE extracted with different solvents. Under optimal conditions, CML formation in the heated model system composed of glucose/lysine/linoleic acid was effectively inhibited by HBBE...
February 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29389628/effect-of-different-cooking-conditions-on-the-profiles-of-maillard-reaction-products-and-nutrient-composition-of-hairtail-thichiurus-lepturus-fillets
#7
Wilson P Semedo Tavares, Shiyuan Dong, Weiya Jin, Yuhong Yang, Kaining Han, Fengchao Zha, Yuanhui Zhao, Mingyong Zeng
Much attention has been given to investigate the formation of Maillard reaction products in thermal processing food due to potential health risks. This study aimed to the profiles of Maillard reaction products (MRPs) and changes of nutrient composition in hairtail (Thichiurus lepturus) fillets prepared by three cooking method: boiling, baking and frying. The Nε-carboxymethyllysine (CML) level ranged from non-detectable to 4.24mg/100g protein and furosine ranged from 4.25 to 20.95mg/100g protein. The levels of CML and furosine in boiled hairtail fillets were much lower than baked and fried ones...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29371774/a-study-of-microalbuminuria-mau-and-advanced-glycation-end-products-ages-levels-in-diabetic-and-hypertensive-subjects
#8
S Gawandi, S Gangawane, A Chakrabarti, S Kedare, K Bantwal, V Wadhe, A Kulkarni, S Kulkarni, M G R Rajan
The prevalence of non-communicable diseases like diabetes mellitus (DM) and hypertension (HTN) is growing worldwide. Both lead to nephropathy if not controlled effectively. Microalbuminuria (MAU) is recognized as an early predictor for nephropathy. Additionally, the timely detection of advanced glycation end products (AGEs) is also considered to be an important prognostic factor for diabetic nephropathies. Hence, screening for the early detection of MAU and AGEs would be an useful and relatively inexpensive laboratory test for early clinical diagnosis for the incidence of nephropathy in these diseases...
January 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29301761/uremic-advanced-glycation-end-products-and-protein-bound-solutes-induce-endothelial-dysfunction-through-suppression-of-kr%C3%A3-ppel-like-factor-2
#9
Keith Saum, Begoña Campos, Diego Celdran-Bonafonte, Lalitha Nayak, Panjamaporn Sangwung, Charuhas Thakar, Prabir Roy-Chaudhury, A Phillip Owens
BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease. The accumulation of uremic solutes in this patient population is associated with endothelial dysfunction and accelerated cardiovascular disease. In this study, we examined the impact of the uremic milieu on the endothelial transcription factor, Krüppel-like factor 2 (KLF2), a key regulator of endothelial function and activation. METHODS AND RESULTS: Using serum from uremic pigs with chronic renal insufficiency, our results show that KLF2 expression is suppressed by the uremic milieu and individual uremic solutes in vitro...
January 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29232895/effects-of-weight-loss-on-advanced-glycation-end-products-in-subjects-with-and-without-diabetes-a-preliminary-report
#10
Permal Deo, Jennifer B Keogh, Naomi J Price, Peter M Clifton
Advanced glycation end-products (AGEs) are formed endogenously as a normal ageing process and during food processing. High levels of AGEs have been implicated in the development of both macrovascular disease and microvascular disease. The purpose of this secondary analysis was to determine whether a major AGE species, N ε -carboxymethyllysine (CML), was reduced after weight loss. CML values decreased by 17% after weight loss. Participants with diabetes and pre-diabetes had a lower CML values at baseline and a smaller change in CML than overweight participants without diabetes...
December 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29220086/zinc-against-advanced-glycation-end-products
#11
REVIEW
Sorayya Kheirouri, Mohammad Alizadeh, Vahid Maleki
Advanced glycation end products (AGEs) are destructive compounds with pathogenic importance in age-related chronic diseases. Zinc has antioxidant, anti-inflammatory and anti-apoptotic potential. This study aimed to summarize effects of zinc on AGE formation and AGE-induced damaging agents. Pubmed, Google scholar, Web of Sciences, and Scopus databases were searched. There was no limitation for publication date. English language original articles (in vitro, experimental and human studies) which examined the effect of external zinc on AGE formation, AGE-induced apoptosis, or oxidative stress in mammals were included...
December 8, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29185795/curcumin-against-advanced-glycation-end-products-ages-and-ages-induced-detrimental-agents
#12
Mohammad Alizadeh, Sorayya Kheirouri
OBJECTIVES: This study was aimed to review and collate effects of curcumin on generation of advanced glycation end products (AGEs) and AGEs induced detrimental agents. METHODS: Pubmed, Googlescholar, ScienceDirect, and Scopus databases were searched. Searching was not limited to specific publication period. Only English language original articles (in vitro, experimental and human) which had examined the effect of curcumin on AGEs formation and AGEs induced apoptosis, oxidative stress or inflammatory responses were included...
November 29, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29111707/lysine-derived-protein-bound-heyns-compounds-in-bakery-products
#13
Stephanie Treibmann, Anne Hellwig, Michael Hellwig, Thomas Henle
Fructose and dicarbonyl compounds resulting from fructose in heated foods have been linked to pathophysiological pathways of several metabolic disorders. Up to now, very little has been known about the Maillard reaction of fructose in food. Heyns rearrangement compounds (HRCs), the first stable intermediates of the Maillard reaction between amino components and fructose, have not yet been quantitated as protein-bound products in food. Therefore, the HRCs glucosyllysine and mannosyllysine were synthesized and characterized by NMR...
December 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29097054/age-albumin-enhances-abca1-degradation-by-ubiquitin-proteasome-and-lysosomal-pathways-in-macrophages
#14
Rodrigo Tallada Iborra, Adriana Machado-Lima, Ligia Shimabukuro Okuda, Paula Ramos Pinto, Edna Regina Nakandakare, Ubiratan Fabres Machado, Maria Lucia Correa-Giannella, Russell Pickford, Tom Woods, Margaret A Brimble, Kerry-Anne Rye, Rui Lu, Shinji Yokoyama, Marisa Passarelli
BACKGROUND AND AIMS: Advanced glycation end products (AGEs) induce cellular oxidative/endoplasmic reticulum stress and inflammation. We investigated its underlying mechanisms for atherogenesis focusing on regulation of ABCA1 protein decay in macrophages. METHODS: The ABCA1 decay rate was evaluated in macrophages after treatment with LXR agonist and by incubation with control (C) or AGE-albumin concomitant or not with cycloheximide, MG-132, ammonium chloride and calpain inhibitors were utilized to inhibit, respectively, proteasome, lysosome and ABCA1 proteolysis at cell surface...
January 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29053168/fl-926-16-a-novel-bioavailable-carnosinase-resistant-carnosine-derivative-prevents-onset-and-stops-progression-of-diabetic-nephropathy-in-db-db-mice
#15
Carla Iacobini, Stefano Menini, Claudia Blasetti Fantauzzi, Carlo M Pesce, Andrea Giaccari, Enrica Salomone, Annunziata Lapolla, Marica Orioli, Giancarlo Aldini, Giuseppe Pugliese
BACKGROUND AND PURPOSE: The advanced glycation end products (AGEs) participate in the pathogenesis of diabetic nephropathy (DN) by promoting renal inflammation and injury. L-carnosine acts as a quencher of the AGE precursors reactive carbonyl species (RCS), but is rapidly inactivated by carnosinase. In this study, we evaluated the effect of FL-926-16, a carnosinase-resistant and bioavailable carnosine derivative, on the onset and progression of DN in db/db mice. EXPERIMENTAL APPROACH: Adult male db/db mice and coeval db/m controls were left untreated or treated with FL-926-16 (30 mg·kg-1 body weight) from weeks 6 to 20 (prevention protocol) or from weeks 20 to 34 (regression protocol)...
January 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29052845/the-advanced-glycation-end-product-n-%C3%AF%C2%B5-carboxymethyllysine-and-its-precursor-glyoxal-increase-serotonin-release-from-caco-2-cells
#16
Ann-Katrin Holik, Barbara Lieder, Nicole Kretschy, Mark M Somoza, Jakob P Ley, Joachim Hans, Veronika Somoza
Advanced glycation end products (AGEs), comprising a highly diverse class of Maillard reaction compounds formed in vivo and during heating processes of foods, have been described in the progression of several degenerative conditions such as Alzheimer's disease and diabetes mellitus. Nϵ -Carboxymethyllysine (CML) represents a well-characterized AGE, which is frequently encountered in a Western diet and is known to mediate its cellular effects through binding to the receptor for AGEs (RAGE). As very little is known about the impact of exogenous CML and its precursor, glyoxal, on intestinal cells, a genome-wide screening using a customized microarray was conducted in fully differentiated Caco-2 cells...
March 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29018354/n-acetylcysteine-counteracts-adipose-tissue-macrophage-infiltration-and-insulin-resistance-elicited-by-advanced-glycated-albumin-in-healthy-rats
#17
Karolline S da Silva, Paula R Pinto, Nelly T Fabre, Diego J Gomes, Karina Thieme, Ligia S Okuda, Rodrigo T Iborra, Vanessa G Freitas, Maria H M Shimizu, Walcy R Teodoro, Suely K N Marie, Tom Woods, Margaret A Brimble, Russell Pickford, Kerry-Anne Rye, Maristela Okamoto, Sergio Catanozi, Maria L Correa-Giannela, Ubiratan F Machado, Marisa Passarelli
Background: Advanced glycation endproducts elicit inflammation. However, their role in adipocyte macrophage infiltration and in the development of insulin resistance, especially in the absence of the deleterious biochemical pathways that coexist in diabetes mellitus, remains unknown. We investigated the effect of chronic administration of advanced glycated albumin (AGE-albumin) in healthy rats, associated or not with N-acetylcysteine (NAC) treatment, on insulin sensitivity, adipose tissue transcriptome and macrophage infiltration and polarization...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28994624/plasma-heparanase-is-associated-with-blood-glucose-levels-but-not-urinary-microalbumin-excretion-in-type-2-diabetic-nephropathy-at-the-early-stage
#18
Yue Zhao, Jingshun Liu, Shichao Ten, Jisheng Zhang, Yanggang Yuan, Jiangyi Yu, Xiaofei An
AIM: To explore the possible correlations between plasma heparanase and albuminuria, glucose and lipid metabolism in the type 2 diabetic nephropathy patients at the early stage. METHODS: One hundred and forty patients with type 2 diabetic nephropathy at early stage were recruited into the study. Plasma heparanase and the characterized advanced glycation end products (AGEs), carboxymethyllysine (CML) were measured by enzyme-linked immunosorbent assay. RESULTS: Plasma heparanase was positively associated with fasting blood glucose (R = 0...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28965192/repeated-oral-exposure-to-n-%C3%AE%C2%B5-carboxymethyllysine-a-maillard-reaction-product-alleviates-gut-microbiota-dysbiosis-in-colitic-mice
#19
Nesreen ALJahdali, Pascale Gadonna-Widehem, Carine Delayre-Orthez, David Marier, Benjamin Garnier, Franck Carbonero, Pauline M Anton
BACKGROUND: Diet is suggested to participate in the etiology of inflammatory bowel diseases (IBD). Repeated exposure to Maillard reaction products (MRPs), molecules resulting from reduction reactions between amino acids and sugars during food heating, has been reported to be either potentially detrimental or beneficial to health. AIMS: The aim of this study is to determine the effect of repeated oral ingestion of Nε -carboxymethyllysine (CML), an advanced MRP, on the onset of two models of experimental IBD and on the gut microbiota composition of mice...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28886871/daf-in-diabetic-patients-is-subject-to-glycation-inactivation-at-its-active-site-residues
#20
Rudolf Flückiger, Enzo Cocuzzi, Ram H Nagaraj, Menachem Shoham, Timothy S Kern, M Edward Medof
Decay accelerating factor (DAF or CD55) is a cell associated C3 and C5 convertase regulator originally described in terms of protection of self-cells from systemic complement but now known to modulate adaptive T cell responses. It is expressed on all cell types. We investigated whether nonenzymatic glycation could impair its function and potentially be relevant to complications of diabetes mellitus and other conditions that result in nonenzymatic glycation including cancer, Alzheimer's disease, and aging. Immunoblots of affinity-purified DAF from erythrocytes of patients with diabetes showed pentosidine, glyoxal-AGEs, carboxymethyllysine, and argpyrimidine...
January 2018: Molecular Immunology
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