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ksr1 degradation

J Stebbing, H Zhang, Y Xu, L C Lit, A R Green, A Grothey, Y Lombardo, M Periyasamy, K Blighe, W Zhang, J A Shaw, I O Ellis, H J Lenz, G Giamas
Kinase suppressor of Ras-1 (KSR1) facilitates signal transduction in Ras-dependent cancers, including pancreatic and lung carcinomas but its role in breast cancer has not been well studied. Here, we demonstrate for the first time it functions as a tumor suppressor in breast cancer in contrast to data in other tumors. Breast cancer patients (n>1000) with high KSR1 showed better disease-free and overall survival, results also supported by Oncomine analyses, microarray data (n=2878) and genomic data from paired tumor and cell-free DNA samples revealing loss of heterozygosity...
April 16, 2015: Oncogene
David Llobet, Nuria Eritja, Monica Domingo, Laura Bergada, Cristina Mirantes, Maria Santacana, Judit Pallares, Anna MaciĆ , Andree Yeramian, Mario Encinas, Gema Moreno-Bueno, Jose Palacios, Robert E Lewis, Xavier Matias-Guiu, Xavi Dolcet
The Raf/MEK/extracellular signal-regulated kinase (ERK) pathway participates in many processes altered in development and progression of cancer in human beings such as proliferation, transformation, differentiation, and apoptosis. Kinase suppressor of Ras 1 (KSR1) can interact with various kinases of the Raf/MEK/extracellular signal-regulated kinase pathway to enhance its activation. The role of KSR1 in endometrial carcinogenesis was investigated. cDNA and tissue microarrays demonstrated that expression of KSR1 was up-regulated in endometrial carcinoma...
April 2011: American Journal of Pathology
Massimiliano Salerno, Diane Palmieri, Amina Bouadis, Douglas Halverson, Patricia S Steeg
Metastatic disease is a significant contributor to cancer patient mortality. We previously reported that the Kinase Suppressor of Ras1 (KSR1) scaffold protein for the Erk mitogen-activated protein kinase pathway coimmunoprecipitated the metastasis suppressor protein Nm23-H1. We now hypothesize that altered expression levels of Nm23-H1 influence the binding properties, stability, and function of the KSR1 scaffold. Increased coimmunoprecipitation of Hsp90 with KSR1 was observed in either stable or transient transfectants of nm23-H1 in MDA-MB-435 human breast carcinoma cells...
February 2005: Molecular and Cellular Biology
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